ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	arginine catabolic process (GO:0006527)	6.15989741
2	otic vesicle formation (GO:0030916)	6.10302144
3	limb bud formation (GO:0060174)	5.71774406
4	preassembly of GPI anchor in ER membrane (GO:0016254)	4.88007819
5	cellular response to interferon-alpha (GO:0035457)	4.69268292
6	presynaptic membrane assembly (GO:0097105)	4.60116347
7	neural tube formation (GO:0001841)	4.36548626
8	kidney morphogenesis (GO:0060993)	4.34581282
9	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.31692474
10	mechanosensory behavior (GO:0007638)	4.25323746
11	cell wall macromolecule catabolic process (GO:0016998)	4.22701120
12	resolution of meiotic recombination intermediates (GO:0000712)	4.05799702
13	platelet dense granule organization (GO:0060155)	3.89823328
14	arginine metabolic process (GO:0006525)	3.89722172
15	glial cell proliferation (GO:0014009)	3.82329472
16	replication fork processing (GO:0031297)	3.77988360
17	cilium morphogenesis (GO:0060271)	3.73713310
18	protein polyglutamylation (GO:0018095)	3.71066883
19	ovulation cycle (GO:0042698)	3.70348778
20	keratinocyte development (GO:0003334)	3.67489020
21	acrosome assembly (GO:0001675)	3.64951141
22	intraciliary transport (GO:0042073)	3.64485957
23	presynaptic membrane organization (GO:0097090)	3.63380396
24	seminiferous tubule development (GO:0072520)	3.61700229
25	protein localization to cilium (GO:0061512)	3.57637988
26	cardiac right ventricle morphogenesis (GO:0003215)	3.53011061
27	DNA damage response, detection of DNA damage (GO:0042769)	3.50889175
28	phospholipid homeostasis (GO:0055091)	3.46656989
29	cell wall macromolecule metabolic process (GO:0044036)	3.42380760
30	sympathetic nervous system development (GO:0048485)	3.38096218
31	prenylation (GO:0097354)	3.34552363
32	protein prenylation (GO:0018342)	3.34552363
33	synaptic transmission, cholinergic (GO:0007271)	3.29590694
34	head development (GO:0060322)	3.26838507
35	snRNA transcription (GO:0009301)	3.24162086
36	regulation of keratinocyte proliferation (GO:0010837)	3.23026812
37	neuronal action potential propagation (GO:0019227)	3.22863117
38	regulation of telomere maintenance (GO:0032204)	3.21834780
39	glycoprotein catabolic process (GO:0006516)	3.19944347
40	establishment of protein localization to Golgi (GO:0072600)	3.17841143
41	negative regulation of amino acid transport (GO:0051956)	3.15276328
42	positive regulation of protein autophosphorylation (GO:0031954)	3.14019304
43	negative regulation of keratinocyte proliferation (GO:0010839)	3.12748680
44	olfactory bulb development (GO:0021772)	3.10317069
45	epithelial cilium movement (GO:0003351)	3.04165786
46	lateral ventricle development (GO:0021670)	3.01787900
47	negative regulation of sodium ion transport (GO:0010766)	3.00896006
48	respiratory chain complex IV assembly (GO:0008535)	2.98529262
49	regulation of mitotic spindle checkpoint (GO:1903504)	2.98187128
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98187128
51	regulation of cilium movement (GO:0003352)	2.98054956
52	sister chromatid cohesion (GO:0007062)	2.97711118
53	reciprocal DNA recombination (GO:0035825)	2.96396965
54	reciprocal meiotic recombination (GO:0007131)	2.96396965
55	lymphoid progenitor cell differentiation (GO:0002320)	2.91842959
56	cilium assembly (GO:0042384)	2.90665974
57	positive regulation of muscle hypertrophy (GO:0014742)	2.90209016
58	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.90209016
59	branched-chain amino acid catabolic process (GO:0009083)	2.88017938
60	cilium organization (GO:0044782)	2.87711562
61	generation of neurons (GO:0048699)	2.84951973
62	central nervous system projection neuron axonogenesis (GO:0021952)	2.84378525
63	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.83394093
64	C-terminal protein lipidation (GO:0006501)	2.83381663
65	phospholipid efflux (GO:0033700)	2.82478526
66	somite development (GO:0061053)	2.80670876
67	regulation of glutamate secretion (GO:0014048)	2.76510101
68	citrulline metabolic process (GO:0000052)	2.75194406
69	central nervous system neuron axonogenesis (GO:0021955)	2.72851641
70	spinal cord motor neuron differentiation (GO:0021522)	2.70759355
71	synapsis (GO:0007129)	2.70637881
72	cardiac ventricle morphogenesis (GO:0003208)	2.70536455
73	rRNA methylation (GO:0031167)	2.69212426
74	hindbrain development (GO:0030902)	2.69082763
75	membrane assembly (GO:0071709)	2.66851718
76	protein targeting to Golgi (GO:0000042)	2.65765052
77	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.65667290
78	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.65667290
79	regulation of translation, ncRNA-mediated (GO:0045974)	2.65667290
80	female genitalia development (GO:0030540)	2.65512681
81	spermatid nucleus differentiation (GO:0007289)	2.65302124
82	peripheral nervous system neuron development (GO:0048935)	2.63967187
83	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.63294410
84	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.60743766
85	peptidyl-cysteine modification (GO:0018198)	2.60692167
86	C-terminal protein amino acid modification (GO:0018410)	2.60614183
87	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.57310905
88	cellular response to cholesterol (GO:0071397)	2.57187837
89	alkaloid metabolic process (GO:0009820)	2.56634459
90	vagina development (GO:0060068)	2.56151423
91	regulation of sarcomere organization (GO:0060297)	2.55638254
92	cytochrome complex assembly (GO:0017004)	2.55581994
93	regulation of feeding behavior (GO:0060259)	2.55444113
94	axoneme assembly (GO:0035082)	2.54725192
95	DNA replication-dependent nucleosome assembly (GO:0006335)	2.53250848
96	DNA replication-dependent nucleosome organization (GO:0034723)	2.53250848
97	positive regulation of actin filament depolymerization (GO:0030836)	2.52953231
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52292976
99	regulation of action potential (GO:0098900)	2.51227158
100	regulation of protein glycosylation (GO:0060049)	2.51100429

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.75963799
2	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.47419720
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45258564
4	FUS_26573619_Chip-Seq_HEK293_Human	3.30414705
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.25083520
6	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.16805777
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.93089127
8	EWS_26573619_Chip-Seq_HEK293_Human	2.84145972
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.73444863
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.58940667
11	P300_19829295_ChIP-Seq_ESCs_Human	2.47474129
12	VDR_22108803_ChIP-Seq_LS180_Human	2.43904355
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36342742
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.12166131
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09524073
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.08811213
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.08280634
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97908682
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.95330953
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89954557
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.85479374
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.84128773
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84128773
24	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.77394769
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.70831598
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70813244
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.66818391
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.66414716
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65083986
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64150951
31	STAT3_23295773_ChIP-Seq_U87_Human	1.64109755
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64044027
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60927838
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.58654424
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57544063
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57177785
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56815809
38	AR_25329375_ChIP-Seq_VCAP_Human	1.56662836
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50446598
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.48279851
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47690853
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47450606
43	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.47253533
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46496027
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41094141
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.39922523
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39459528
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.38750945
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.38283020
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.37222041
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33138196
52	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32683017
53	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.32619092
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32164145
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31953399
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.31745742
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.29004299
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29004299
59	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.27589849
60	TCF4_23295773_ChIP-Seq_U87_Human	1.26222282
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25281712
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24465053
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24148890
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.23498259
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23439491
66	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.22008019
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.21244654
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20409136
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18621541
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18621541
71	TP53_16413492_ChIP-PET_HCT116_Human	1.17845496
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17718304
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.15390511
74	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13434544
75	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.10358958
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10144350
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09459114
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09385194
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08521807
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07756254
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07431766
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.07043674
83	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06698756
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06698756
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06212592
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06092826
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05906268
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05902641
89	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05691753
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03518817
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01577786
92	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00769149
93	VDR_23849224_ChIP-Seq_CD4+_Human	1.00630286
94	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00242739
95	JUN_21703547_ChIP-Seq_K562_Human	1.00208904
96	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99895963
97	BRD4_25478319_ChIP-Seq_HGPS_Human	0.98948333
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.98877171
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98747585
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98637513

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	5.04334493
2	MP0006054_spinal_hemorrhage	3.95707486
3	MP0003941_abnormal_skin_development	3.15185998
4	MP0003787_abnormal_imprinting	2.88782565
5	MP0008877_abnormal_DNA_methylation	2.77305456
6	MP0005367_renal/urinary_system_phenotyp	2.72738217
7	MP0000516_abnormal_urinary_system	2.72738217
8	MP0000372_irregular_coat_pigmentation	2.70899016
9	MP0002751_abnormal_autonomic_nervous	2.44360688
10	MP0001984_abnormal_olfaction	2.41983329
11	MP0003191_abnormal_cellular_cholesterol	2.33310686
12	MP0004133_heterotaxia	2.20098461
13	MP0004215_abnormal_myocardial_fiber	2.17953308
14	MP0002102_abnormal_ear_morphology	2.15827790
15	MP0001293_anophthalmia	2.12875193
16	MP0000778_abnormal_nervous_system	2.08210153
17	MP0005551_abnormal_eye_electrophysiolog	2.01411993
18	MP0005423_abnormal_somatic_nervous	1.94239532
19	MP0005171_absent_coat_pigmentation	1.89702575
20	MP0002282_abnormal_trachea_morphology	1.74553397
21	MP0003880_abnormal_central_pattern	1.74360133
22	MP0003890_abnormal_embryonic-extraembry	1.73602441
23	MP0003950_abnormal_plasma_membrane	1.68757919
24	MP0002938_white_spotting	1.68322909
25	MP0006292_abnormal_olfactory_placode	1.66427928
26	MP0001529_abnormal_vocalization	1.58961801
27	MP0002928_abnormal_bile_duct	1.52516351
28	MP0001299_abnormal_eye_distance/	1.49241119
29	MP0004145_abnormal_muscle_electrophysio	1.46680241
30	MP0003137_abnormal_impulse_conducting	1.44684430
31	MP0003937_abnormal_limbs/digits/tail_de	1.44202274
32	MP0003136_yellow_coat_color	1.43407352
33	MP0005253_abnormal_eye_physiology	1.41015028
34	MP0002736_abnormal_nociception_after	1.39274073
35	MP0005084_abnormal_gallbladder_morpholo	1.38533057
36	MP0001485_abnormal_pinna_reflex	1.35266587
37	MP0001968_abnormal_touch/_nociception	1.33786134
38	MP0006072_abnormal_retinal_apoptosis	1.33100975
39	MP0002168_other_aberrant_phenotype	1.32660414
40	MP0004084_abnormal_cardiac_muscle	1.31478796
41	MP0001486_abnormal_startle_reflex	1.29061661
42	MP0001986_abnormal_taste_sensitivity	1.25820273
43	MP0000639_abnormal_adrenal_gland	1.24052040
44	MP0005623_abnormal_meninges_morphology	1.20643108
45	MP0003121_genomic_imprinting	1.19941144
46	MP0004085_abnormal_heartbeat	1.19790592
47	MP0008789_abnormal_olfactory_epithelium	1.19069457
48	MP0002233_abnormal_nose_morphology	1.17301882
49	MP0003385_abnormal_body_wall	1.14714000
50	MP0003315_abnormal_perineum_morphology	1.11290535
51	MP0009250_abnormal_appendicular_skeleto	1.09805665
52	MP0000427_abnormal_hair_cycle	1.08865855
53	MP0005410_abnormal_fertilization	1.06807905
54	MP0002277_abnormal_respiratory_mucosa	1.06366148
55	MP0003646_muscle_fatigue	1.06232287
56	MP0002090_abnormal_vision	1.06092582
57	MP0000569_abnormal_digit_pigmentation	1.05178430
58	MP0003755_abnormal_palate_morphology	1.04563388
59	MP0005195_abnormal_posterior_eye	1.03168412
60	MP0000383_abnormal_hair_follicle	1.02722604
61	MP0000538_abnormal_urinary_bladder	1.01629762
62	MP0005395_other_phenotype	1.00988137
63	MP0000749_muscle_degeneration	0.99646902
64	MP0002752_abnormal_somatic_nervous	0.99366635
65	MP0002638_abnormal_pupillary_reflex	0.94398381
66	MP0004264_abnormal_extraembryonic_tissu	0.93689119
67	MP0005174_abnormal_tail_pigmentation	0.93508101
68	MP0000537_abnormal_urethra_morphology	0.92653594
69	MP0002184_abnormal_innervation	0.92460265
70	MP0005499_abnormal_olfactory_system	0.91903539
71	MP0005394_taste/olfaction_phenotype	0.91903539
72	MP0005332_abnormal_amino_acid	0.88757186
73	MP0002160_abnormal_reproductive_system	0.87737319
74	MP0003943_abnormal_hepatobiliary_system	0.86398103
75	MP0003011_delayed_dark_adaptation	0.85414640
76	MP0001324_abnormal_eye_pigmentation	0.84756529
77	MP0001119_abnormal_female_reproductive	0.82155042
78	MP0005386_behavior/neurological_phenoty	0.81539627
79	MP0004924_abnormal_behavior	0.81539627
80	MP0004142_abnormal_muscle_tone	0.78260661
81	MP0001286_abnormal_eye_development	0.77629624
82	MP0005391_vision/eye_phenotype	0.76164684
83	MP0005220_abnormal_exocrine_pancreas	0.73337015
84	MP0003283_abnormal_digestive_organ	0.72483457
85	MP0003119_abnormal_digestive_system	0.72073214
86	MP0001666_abnormal_nutrient_absorption	0.71261563
87	MP0000647_abnormal_sebaceous_gland	0.70204946
88	MP0003718_maternal_effect	0.68794198
89	MP0000955_abnormal_spinal_cord	0.68659526
90	MP0003935_abnormal_craniofacial_develop	0.67244663
91	MP0002067_abnormal_sensory_capabilities	0.67138927
92	MP0010030_abnormal_orbit_morphology	0.67126642
93	MP0001440_abnormal_grooming_behavior	0.65802931
94	MP0008995_early_reproductive_senescence	0.65699160
95	MP0002734_abnormal_mechanical_nocicepti	0.64495591
96	MP0001177_atelectasis	0.64051095
97	MP0002127_abnormal_cardiovascular_syste	0.62304725
98	MP0000631_abnormal_neuroendocrine_gland	0.62207989
99	MP0002295_abnormal_pulmonary_circulatio	0.62034097
100	MP0001929_abnormal_gametogenesis	0.62018885

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	4.41508242
2	Bifid tongue (HP:0010297)	4.30291978
3	Molar tooth sign on MRI (HP:0002419)	4.12701191
4	Abnormality of midbrain morphology (HP:0002418)	4.12701191
5	Pancreatic fibrosis (HP:0100732)	3.88816753
6	True hermaphroditism (HP:0010459)	3.76219156
7	Hyperventilation (HP:0002883)	3.61894016
8	Volvulus (HP:0002580)	3.60104267
9	Supernumerary spleens (HP:0009799)	3.42211593
10	Pancreatic cysts (HP:0001737)	3.41433101
11	Gait imbalance (HP:0002141)	3.39162118
12	Facial diplegia (HP:0001349)	3.37384139
13	Hypoalphalipoproteinemia (HP:0003233)	3.25886422
14	Renal cortical cysts (HP:0000803)	3.08054825
15	Medial flaring of the eyebrow (HP:0010747)	3.00854995
16	Genital tract atresia (HP:0001827)	2.96418501
17	Congenital primary aphakia (HP:0007707)	2.96063096
18	Popliteal pterygium (HP:0009756)	2.94319245
19	Chronic hepatic failure (HP:0100626)	2.88938248
20	Nephronophthisis (HP:0000090)	2.87480944
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.83471568
22	Vaginal atresia (HP:0000148)	2.83155471
23	Cystic liver disease (HP:0006706)	2.82303034
24	Poor coordination (HP:0002370)	2.78921644
25	Type 2 muscle fiber atrophy (HP:0003554)	2.76702415
26	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.74059894
27	Tented upper lip vermilion (HP:0010804)	2.67302381
28	Chorioretinal atrophy (HP:0000533)	2.66268237
29	Gastrointestinal atresia (HP:0002589)	2.63377730
30	Nephrogenic diabetes insipidus (HP:0009806)	2.62813768
31	Methylmalonic acidemia (HP:0002912)	2.61616781
32	Rectal fistula (HP:0100590)	2.57146255
33	Rectovaginal fistula (HP:0000143)	2.57146255
34	Narrow forehead (HP:0000341)	2.53320959
35	Absent speech (HP:0001344)	2.51537635
36	Anal stenosis (HP:0002025)	2.44771351
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.39570826
38	Oculomotor apraxia (HP:0000657)	2.37067868
39	Abnormality of the renal cortex (HP:0011035)	2.35758944
40	Abnormality of the renal medulla (HP:0100957)	2.34466395
41	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.33970571
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31072214
43	Congenital stationary night blindness (HP:0007642)	2.27014295
44	Short tibia (HP:0005736)	2.25826884
45	Postaxial foot polydactyly (HP:0001830)	2.24901875
46	Hypolipoproteinemia (HP:0010981)	2.20616799
47	Abnormal biliary tract physiology (HP:0012439)	2.17589044
48	Bile duct proliferation (HP:0001408)	2.17589044
49	Abnormality of the middle phalanges of the toes (HP:0010183)	2.16928195
50	Hyperglycinemia (HP:0002154)	2.15944415
51	Aplasia/Hypoplasia of the lens (HP:0008063)	2.14189684
52	Congenital hepatic fibrosis (HP:0002612)	2.11901451
53	Postaxial hand polydactyly (HP:0001162)	2.09751574
54	Muscle fiber atrophy (HP:0100295)	2.08924702
55	Preaxial hand polydactyly (HP:0001177)	2.08199375
56	Abnormality of methionine metabolism (HP:0010901)	2.08180594
57	Vaginal fistula (HP:0004320)	2.07817641
58	Chorioretinal coloboma (HP:0000567)	2.06942067
59	Abnormality of placental membranes (HP:0011409)	2.05819713
60	Amniotic constriction ring (HP:0009775)	2.05819713
61	Febrile seizures (HP:0002373)	2.05003600
62	Occipital encephalocele (HP:0002085)	2.04288337
63	Intestinal fistula (HP:0100819)	2.01743733
64	Acute encephalopathy (HP:0006846)	2.00382187
65	Left ventricular hypertrophy (HP:0001712)	1.98630432
66	Male pseudohermaphroditism (HP:0000037)	1.97984298
67	Abnormality of the ischium (HP:0003174)	1.97960022
68	Anencephaly (HP:0002323)	1.97411523
69	Enlarged epiphyses (HP:0010580)	1.94950089
70	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.93544486
71	Abnormality of macular pigmentation (HP:0008002)	1.93294051
72	Anal atresia (HP:0002023)	1.89959468
73	Papilledema (HP:0001085)	1.89476158
74	Thyroiditis (HP:0100646)	1.84735453
75	Impaired pain sensation (HP:0007328)	1.84485830
76	Abnormality of pain sensation (HP:0010832)	1.84485830
77	Sclerocornea (HP:0000647)	1.83176734
78	Ectropion (HP:0000656)	1.80958242
79	Cupped ear (HP:0000378)	1.80783625
80	Ependymoma (HP:0002888)	1.79523204
81	Abnormality of renal resorption (HP:0011038)	1.79011338
82	Hypoplasia of the fovea (HP:0007750)	1.76064480
83	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76064480
84	Preaxial foot polydactyly (HP:0001841)	1.75982045
85	Depressed nasal tip (HP:0000437)	1.75674744
86	Abnormal drinking behavior (HP:0030082)	1.74993744
87	Polydipsia (HP:0001959)	1.74993744
88	Absent eyebrow (HP:0002223)	1.74808640
89	Progressive inability to walk (HP:0002505)	1.74798015
90	Atonic seizures (HP:0010819)	1.74544950
91	Tachypnea (HP:0002789)	1.73668418
92	Amblyopia (HP:0000646)	1.72740379
93	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.71882141
94	Decreased muscle mass (HP:0003199)	1.71752019
95	Abnormality of the fovea (HP:0000493)	1.68327783
96	Astigmatism (HP:0000483)	1.66937818
97	Scrotal hypoplasia (HP:0000046)	1.61869915
98	Renal hypoplasia (HP:0000089)	1.61224701
99	Short foot (HP:0001773)	1.61086174
100	Multicystic kidney dysplasia (HP:0000003)	1.60236797

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.04601525
2	MAPK13	3.55633715
3	TLK1	3.54640848
4	MARK1	3.48628399
5	CASK	3.41853344
6	TRIM28	3.16432437
7	WNK3	2.87923618
8	BMPR1B	2.87301643
9	BCR	2.45449533
10	NUAK1	2.38575762
11	EIF2AK3	2.34701665
12	GRK7	2.20645322
13	ACVR1B	1.90557821
14	MAP4K2	1.85828456
15	AKT3	1.78455054
16	SIK3	1.77219316
17	LIMK1	1.74700148
18	PKN1	1.69692798
19	PAK3	1.65610169
20	TNIK	1.58088011
21	ERBB3	1.47673721
22	BRSK2	1.44118015
23	ZAK	1.42296261
24	FGFR2	1.40290238
25	WNK4	1.34384776
26	STK39	1.29964390
27	MKNK2	1.28720657
28	GRK1	1.25504804
29	TGFBR1	1.25184911
30	MKNK1	1.24125464
31	MAP3K12	1.18694311
32	INSRR	1.14199150
33	PLK3	1.12619703
34	PLK2	1.05999478
35	EIF2AK2	1.02882631
36	MST4	1.00817729
37	NEK9	1.00345105
38	ROCK1	1.00224644
39	CSNK1G2	0.97814932
40	EIF2AK1	0.94835722
41	EPHA4	0.84618589
42	NME1	0.78313668
43	LATS1	0.77443488
44	PRKCE	0.76298069
45	OXSR1	0.75115901
46	PHKG2	0.71061433
47	PHKG1	0.71061433
48	DYRK1A	0.70553982
49	TNK2	0.69092757
50	ADRBK1	0.64510190
51	DMPK	0.63709285
52	TGFBR2	0.62766788
53	STK38L	0.60782717
54	MAP3K4	0.58337016
55	DYRK2	0.58084544
56	DAPK2	0.57847468
57	PDK2	0.57440153
58	RPS6KA5	0.55599104
59	CSNK1A1L	0.55410004
60	TESK1	0.53862062
61	MINK1	0.53373260
62	PRKD3	0.52875201
63	BCKDK	0.50491100
64	PLK1	0.49676835
65	ATM	0.45962822
66	NTRK2	0.43954945
67	PRKCG	0.43660993
68	PRKG1	0.43489472
69	ABL1	0.43301680
70	OBSCN	0.41673862
71	SGK2	0.41409832
72	PRKCZ	0.40573123
73	NEK1	0.39359730
74	PRKDC	0.38652787
75	STK3	0.38132605
76	PRKACA	0.36970023
77	CSNK1D	0.36352054
78	ADRBK2	0.36247004
79	PINK1	0.36050267
80	CSNK1G1	0.35207238
81	DYRK3	0.35153326
82	SGK223	0.35093130
83	SGK494	0.35093130
84	CAMK2D	0.34874699
85	PRKCI	0.34073139
86	PRKCB	0.33855860
87	BRSK1	0.32617469
88	MAPK15	0.32316339
89	TSSK6	0.32146071
90	PNCK	0.31722234
91	INSR	0.31436578
92	MUSK	0.30845356
93	PRKACB	0.29738591
94	SIK2	0.29167929
95	MARK3	0.29110436
96	RPS6KB1	0.28575937
97	CAMKK2	0.28052628
98	CDK8	0.26509441
99	MAP3K2	0.25880277
100	FER	0.25509605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.89370019
2	Propanoate metabolism_Homo sapiens_hsa00640	3.76105642
3	Protein export_Homo sapiens_hsa03060	3.09484621
4	Basal transcription factors_Homo sapiens_hsa03022	2.87181421
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.62724257
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53852266
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.45798270
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.42161123
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.07549953
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.98651285
11	Phototransduction_Homo sapiens_hsa04744	1.74678110
12	Homologous recombination_Homo sapiens_hsa03440	1.71465842
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71298765
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.60708904
15	Butanoate metabolism_Homo sapiens_hsa00650	1.59100562
16	RNA polymerase_Homo sapiens_hsa03020	1.56778548
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50612911
18	Circadian rhythm_Homo sapiens_hsa04710	1.48813652
19	RNA degradation_Homo sapiens_hsa03018	1.48371537
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37841973
21	Fatty acid degradation_Homo sapiens_hsa00071	1.35891968
22	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.34146465
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.33749614
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32561769
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32054074
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29899977
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28130174
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.27127091
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.26870813
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.22616524
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17990969
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16271940
33	Olfactory transduction_Homo sapiens_hsa04740	1.16204437
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.11326672
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10167189
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.09443643
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08274920
38	Lysine degradation_Homo sapiens_hsa00310	1.07396976
39	Caffeine metabolism_Homo sapiens_hsa00232	1.07050471
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.06899143
41	Taste transduction_Homo sapiens_hsa04742	1.01126064
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.97775162
43	RNA transport_Homo sapiens_hsa03013	0.92889518
44	Proteasome_Homo sapiens_hsa03050	0.91114506
45	Tight junction_Homo sapiens_hsa04530	0.89023553
46	Peroxisome_Homo sapiens_hsa04146	0.87556319
47	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.86827955
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86541196
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85117454
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.83129513
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.82945339
52	Circadian entrainment_Homo sapiens_hsa04713	0.80962938
53	Axon guidance_Homo sapiens_hsa04360	0.80829181
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80619121
55	Nicotine addiction_Homo sapiens_hsa05033	0.79816384
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78564305
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.78103733
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.75969545
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.75607910
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75509746
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73060274
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72857401
63	Huntingtons disease_Homo sapiens_hsa05016	0.72232967
64	p53 signaling pathway_Homo sapiens_hsa04115	0.68399741
65	Retinol metabolism_Homo sapiens_hsa00830	0.67879246
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66586426
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.66527417
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66120702
69	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.64120372
70	ABC transporters_Homo sapiens_hsa02010	0.63826310
71	Purine metabolism_Homo sapiens_hsa00230	0.63727589
72	Amphetamine addiction_Homo sapiens_hsa05031	0.61570797
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.59290670
74	African trypanosomiasis_Homo sapiens_hsa05143	0.58934481
75	Oxidative phosphorylation_Homo sapiens_hsa00190	0.58735796
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.58053712
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.57461213
78	Sulfur metabolism_Homo sapiens_hsa00920	0.55959925
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.55104341
80	Oocyte meiosis_Homo sapiens_hsa04114	0.53610612
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52112090
82	Insulin secretion_Homo sapiens_hsa04911	0.51883076
83	Metabolic pathways_Homo sapiens_hsa01100	0.51537512
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50876107
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50705186
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50608177
87	Serotonergic synapse_Homo sapiens_hsa04726	0.50570206
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49934570
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48761100
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47547203
91	Melanogenesis_Homo sapiens_hsa04916	0.47080142
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46787105
93	Parkinsons disease_Homo sapiens_hsa05012	0.46496218
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46171561
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46031264
96	Morphine addiction_Homo sapiens_hsa05032	0.44928709
97	Regulation of autophagy_Homo sapiens_hsa04140	0.43667513
98	GABAergic synapse_Homo sapiens_hsa04727	0.43480183
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42383522
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.40130277

C1GALT1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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