ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	9.44992222
2	regulation of cholesterol esterification (GO:0010872)	8.82916957
3	high-density lipoprotein particle remodeling (GO:0034375)	8.59310848
4	reverse cholesterol transport (GO:0043691)	8.45678064
5	phospholipid efflux (GO:0033700)	8.07669869
6	protein neddylation (GO:0045116)	7.57335452
7	plasma lipoprotein particle assembly (GO:0034377)	7.45316859
8	phospholipid homeostasis (GO:0055091)	7.03554764
9	protein-lipid complex assembly (GO:0065005)	6.50334124
10	protein-lipid complex remodeling (GO:0034368)	6.42671172
11	macromolecular complex remodeling (GO:0034367)	6.42671172
12	plasma lipoprotein particle remodeling (GO:0034369)	6.42671172
13	regulation of cytokine secretion involved in immune response (GO:0002739)	6.25735305
14	low-density lipoprotein particle remodeling (GO:0034374)	5.79152072
15	plasma lipoprotein particle organization (GO:0071827)	5.66886445
16	cholesterol efflux (GO:0033344)	5.52309096
17	protein-lipid complex subunit organization (GO:0071825)	5.25891645
18	negative chemotaxis (GO:0050919)	5.13868124
19	positive regulation of Rho protein signal transduction (GO:0035025)	4.98934313
20	plasma lipoprotein particle clearance (GO:0034381)	4.80026089
21	negative regulation of lipase activity (GO:0060192)	4.69963395
22	neutral lipid catabolic process (GO:0046461)	4.68033824
23	acylglycerol catabolic process (GO:0046464)	4.68033824
24	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.62829704
25	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.57897775
26	L-ascorbic acid metabolic process (GO:0019852)	4.44547303
27	keratinocyte development (GO:0003334)	4.32819951
28	otic vesicle formation (GO:0030916)	4.31892654
29	very-low-density lipoprotein particle assembly (GO:0034379)	4.28360305
30	sterol transport (GO:0015918)	4.26236454
31	cholesterol transport (GO:0030301)	4.26236454
32	regulation of heterotypic cell-cell adhesion (GO:0034114)	4.15370370
33	negative regulation of cholesterol transport (GO:0032375)	4.03725643
34	negative regulation of sterol transport (GO:0032372)	4.03725643
35	negative regulation of sodium ion transport (GO:0010766)	3.97598311
36	triglyceride homeostasis (GO:0070328)	3.94907301
37	acylglycerol homeostasis (GO:0055090)	3.94907301
38	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.93104999
39	triglyceride catabolic process (GO:0019433)	3.92629870
40	regulation of digestive system process (GO:0044058)	3.85011875
41	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.75138538
42	positive regulation of steroid metabolic process (GO:0045940)	3.64162796
43	positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)	3.60635446
44	regulation of glutamate secretion (GO:0014048)	3.58489851
45	glycerolipid catabolic process (GO:0046503)	3.56947999
46	platelet dense granule organization (GO:0060155)	3.55018901
47	thrombin receptor signaling pathway (GO:0070493)	3.52073069
48	regulation of sterol transport (GO:0032371)	3.48901205
49	regulation of cholesterol transport (GO:0032374)	3.48901205
50	lipoprotein metabolic process (GO:0042157)	3.41614242
51	cholesterol homeostasis (GO:0042632)	3.32501964
52	negative regulation of amino acid transport (GO:0051956)	3.30391746
53	regulation of protein glycosylation (GO:0060049)	3.29084697
54	sterol homeostasis (GO:0055092)	3.22285768
55	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.22211913
56	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.19296776
57	opioid receptor signaling pathway (GO:0038003)	3.18093540
58	blood coagulation, intrinsic pathway (GO:0007597)	3.17026062
59	negative regulation of norepinephrine secretion (GO:0010700)	3.13915999
60	regulation of lipoprotein metabolic process (GO:0050746)	3.13257872
61	angiogenesis involved in wound healing (GO:0060055)	3.10988462
62	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.07063372
63	regulation of macrophage derived foam cell differentiation (GO:0010743)	3.03647667
64	response to pheromone (GO:0019236)	2.95017790
65	cardiac left ventricle morphogenesis (GO:0003214)	2.94837415
66	valine metabolic process (GO:0006573)	2.92063933
67	regulation of cholesterol storage (GO:0010885)	2.91674900
68	negative regulation of platelet activation (GO:0010544)	2.90596559
69	Golgi transport vesicle coating (GO:0048200)	2.89155824
70	COPI coating of Golgi vesicle (GO:0048205)	2.89155824
71	negative regulation of interleukin-1 beta production (GO:0032691)	2.88491251
72	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	2.87558654
73	response to BMP (GO:0071772)	2.84010865
74	cellular response to BMP stimulus (GO:0071773)	2.84010865
75	regulation of coenzyme metabolic process (GO:0051196)	2.81469045
76	regulation of cofactor metabolic process (GO:0051193)	2.81469045
77	leukocyte migration involved in inflammatory response (GO:0002523)	2.80221976
78	fatty acid elongation (GO:0030497)	2.77959105
79	platelet aggregation (GO:0070527)	2.74910015
80	positive regulation of muscle hypertrophy (GO:0014742)	2.74558343
81	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.74558343
82	auditory receptor cell differentiation (GO:0042491)	2.73132250
83	bile acid biosynthetic process (GO:0006699)	2.72703345
84	regulation of substrate adhesion-dependent cell spreading (GO:1900024)	2.72082796
85	peptidyl-cysteine modification (GO:0018198)	2.70785965
86	multicellular organism reproduction (GO:0032504)	2.69757789
87	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.67928274
88	negative regulation of protein localization to cell surface (GO:2000009)	2.67642821
89	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.67441316
90	peptidyl-glutamic acid carboxylation (GO:0017187)	2.66175813
91	protein carboxylation (GO:0018214)	2.66175813
92	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.61272672
93	arginine catabolic process (GO:0006527)	2.60995081
94	intra-Golgi vesicle-mediated transport (GO:0006891)	2.60902833
95	neutrophil activation involved in immune response (GO:0002283)	2.60342158
96	adenosine metabolic process (GO:0046085)	2.60192157
97	negative regulation of heart rate (GO:0010459)	2.56835618
98	glycerophospholipid catabolic process (GO:0046475)	2.56695100
99	cellular ketone body metabolic process (GO:0046950)	2.56334899
100	glycoprotein catabolic process (GO:0006516)	2.53486354

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46013205
2	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.82475728
3	TAF15_26573619_Chip-Seq_HEK293_Human	2.79568158
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.68458362
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59460299
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36041588
7	VDR_22108803_ChIP-Seq_LS180_Human	2.34416897
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.32854900
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.21744734
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17770999
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.14362969
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14321651
13	P300_19829295_ChIP-Seq_ESCs_Human	2.06064831
14	FUS_26573619_Chip-Seq_HEK293_Human	2.04446154
15	EWS_26573619_Chip-Seq_HEK293_Human	2.04311070
16	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85618206
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.81068114
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.80956075
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.75443021
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75137561
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73168247
22	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.70261348
23	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.70261348
24	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.69166995
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67660858
26	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.66844942
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.65364886
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.65364886
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62065957
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.59761586
31	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.59064296
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58992415
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55359276
34	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.52746951
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52089169
36	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.50611345
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.50096264
38	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.49293952
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48865065
40	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.45995175
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45740740
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43586855
43	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.43525935
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43506702
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43064301
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.42528717
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41147105
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.41088480
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.40696419
50	GATA4_25053715_ChIP-Seq_YYC3_Human	1.39452810
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39406401
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39406401
53	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.37545610
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36448003
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.33896544
56	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.32036290
57	AR_25329375_ChIP-Seq_VCAP_Human	1.31870675
58	ZNF274_21170338_ChIP-Seq_K562_Hela	1.29840778
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.28749901
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27552659
61	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.27551693
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26355143
63	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.24958108
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21933179
65	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20385873
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19304522
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18727697
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.17602233
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17112536
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15951404
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14881011
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14777981
73	TCF4_23295773_ChIP-Seq_U87_Human	1.13929624
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13432657
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11173883
76	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10879452
77	STAT3_23295773_ChIP-Seq_U87_Human	1.08999749
78	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08348644
79	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.07129917
80	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.06426415
81	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06413241
82	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.06006055
83	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05787302
84	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05641752
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.05512538
86	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04547436
87	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.03458097
88	CBP_20019798_ChIP-Seq_JUKART_Human	1.03273574
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03273574
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02313533
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01504766
92	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.00893120
93	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00562419
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00360934
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.99818722
96	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99422387
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99392696
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99318086
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99015614
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.98863438

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	7.25152159
2	MP0003191_abnormal_cellular_cholesterol	5.12980886
3	MP0005464_abnormal_platelet_physiology	4.88202477
4	MP0006292_abnormal_olfactory_placode	4.11516698
5	MP0008004_abnormal_stomach_pH	3.53255924
6	MP0005367_renal/urinary_system_phenotyp	3.46375561
7	MP0000516_abnormal_urinary_system	3.46375561
8	MP0009840_abnormal_foam_cell	3.33667720
9	MP0010329_abnormal_lipoprotein_level	3.31715987
10	MP0001986_abnormal_taste_sensitivity	3.22158104
11	MP0002254_reproductive_system_inflammat	2.96478412
12	MP0009780_abnormal_chondrocyte_physiolo	2.71541894
13	MP0005084_abnormal_gallbladder_morpholo	2.55087761
14	MP0004264_abnormal_extraembryonic_tissu	2.40289421
15	MP0005410_abnormal_fertilization	2.28279856
16	MP0000537_abnormal_urethra_morphology	2.12987482
17	MP0004215_abnormal_myocardial_fiber	2.08638458
18	MP0004272_abnormal_basement_membrane	2.08141039
19	MP0003385_abnormal_body_wall	1.90053982
20	MP0003315_abnormal_perineum_morphology	1.84924561
21	MP0003890_abnormal_embryonic-extraembry	1.83200891
22	MP0005365_abnormal_bile_salt	1.72505635
23	MP0000639_abnormal_adrenal_gland	1.71184327
24	MP0001293_anophthalmia	1.69875621
25	MP0003941_abnormal_skin_development	1.69568926
26	MP0003136_yellow_coat_color	1.61599751
27	MP0002139_abnormal_hepatobiliary_system	1.61423006
28	MP0001666_abnormal_nutrient_absorption	1.58707196
29	MP0004019_abnormal_vitamin_homeostasis	1.42084205
30	MP0005085_abnormal_gallbladder_physiolo	1.28261851
31	MP0002736_abnormal_nociception_after	1.27072609
32	MP0008775_abnormal_heart_ventricle	1.25243642
33	MP0008877_abnormal_DNA_methylation	1.21826658
34	MP0002938_white_spotting	1.16115076
35	MP0005551_abnormal_eye_electrophysiolog	1.11582507
36	MP0003724_increased_susceptibility_to	1.11066037
37	MP0002277_abnormal_respiratory_mucosa	1.07487043
38	MP0009697_abnormal_copulation	1.06615406
39	MP0003718_maternal_effect	1.05636129
40	MP0000465_gastrointestinal_hemorrhage	1.04548391
41	MP0002168_other_aberrant_phenotype	1.03473790
42	MP0005395_other_phenotype	1.02900119
43	MP0004133_heterotaxia	1.01432759
44	MP0004484_altered_response_of	1.00683017
45	MP0003567_abnormal_fetal_cardiomyocyte	1.00339798
46	MP0005408_hypopigmentation	1.00297394
47	MP0004130_abnormal_muscle_cell	0.99874516
48	MP0001915_intracranial_hemorrhage	0.99123988
49	MP0008875_abnormal_xenobiotic_pharmacok	0.94549719
50	MP0002138_abnormal_hepatobiliary_system	0.93765651
51	MP0004084_abnormal_cardiac_muscle	0.93496676
52	MP0002233_abnormal_nose_morphology	0.91984629
53	MP0003195_calcinosis	0.89530564
54	MP0003137_abnormal_impulse_conducting	0.85371833
55	MP0003938_abnormal_ear_development	0.84978716
56	MP0001879_abnormal_lymphatic_vessel	0.83536632
57	MP0002972_abnormal_cardiac_muscle	0.79303358
58	MP0005083_abnormal_biliary_tract	0.78887978
59	MP0003868_abnormal_feces_composition	0.78090824
60	MP0005332_abnormal_amino_acid	0.77674476
61	MP0003122_maternal_imprinting	0.77415583
62	MP0000778_abnormal_nervous_system	0.76328734
63	MP0001697_abnormal_embryo_size	0.76098177
64	MP0000604_amyloidosis	0.74731605
65	MP0002295_abnormal_pulmonary_circulatio	0.74626102
66	MP0005636_abnormal_mineral_homeostasis	0.74472452
67	MP0002118_abnormal_lipid_homeostasis	0.74468006
68	MP0002128_abnormal_blood_circulation	0.73352547
69	MP0003186_abnormal_redox_activity	0.71970072
70	MP0008789_abnormal_olfactory_epithelium	0.70600489
71	MP0000230_abnormal_systemic_arterial	0.70261570
72	MP0000372_irregular_coat_pigmentation	0.68450570
73	MP0005167_abnormal_blood-brain_barrier	0.65683961
74	MP0000631_abnormal_neuroendocrine_gland	0.64964937
75	MP0004085_abnormal_heartbeat	0.64195799
76	MP0004883_abnormal_blood_vessel	0.63769228
77	MP0005646_abnormal_pituitary_gland	0.63552704
78	MP0003119_abnormal_digestive_system	0.63446171
79	MP0005058_abnormal_lysosome_morphology	0.63165334
80	MP0003937_abnormal_limbs/digits/tail_de	0.63137206
81	MP0001119_abnormal_female_reproductive	0.62768034
82	MP0000249_abnormal_blood_vessel	0.62422105
83	MP0005174_abnormal_tail_pigmentation	0.61082266
84	MP0005394_taste/olfaction_phenotype	0.61074176
85	MP0005499_abnormal_olfactory_system	0.61074176
86	MP0009642_abnormal_blood_homeostasis	0.60443123
87	MP0008872_abnormal_physiological_respon	0.59913614
88	MP0000566_synostosis	0.59763844
89	MP0009384_cardiac_valve_regurgitation	0.53238804
90	MP0005620_abnormal_muscle_contractility	0.52274772
91	MP0006036_abnormal_mitochondrial_physio	0.50987785
92	MP0001299_abnormal_eye_distance/	0.50200997
93	MP0002876_abnormal_thyroid_physiology	0.49287348
94	MP0005623_abnormal_meninges_morphology	0.48727349
95	MP0005310_abnormal_salivary_gland	0.48509423
96	MP0001544_abnormal_cardiovascular_syste	0.48313375
97	MP0005385_cardiovascular_system_phenoty	0.48313375
98	MP0002084_abnormal_developmental_patter	0.47700453
99	MP0003183_abnormal_peptide_metabolism	0.47435899
100	MP0002088_abnormal_embryonic_growth/wei	0.47365649

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperlipoproteinemia (HP:0010980)	5.87470573
2	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	5.79976999
3	Hypoalphalipoproteinemia (HP:0003233)	5.10290750
4	Spontaneous abortion (HP:0005268)	4.86808429
5	Menorrhagia (HP:0000132)	4.80098320
6	Gingival bleeding (HP:0000225)	4.70032046
7	Hypolipoproteinemia (HP:0010981)	4.65111515
8	Prolonged bleeding time (HP:0003010)	4.61194620
9	Abnormality of the common coagulation pathway (HP:0010990)	4.58636377
10	Epidermoid cyst (HP:0200040)	4.34797783
11	Hyperglycinemia (HP:0002154)	4.26577094
12	Increased mean platelet volume (HP:0011877)	4.25102385
13	Renal cortical cysts (HP:0000803)	4.19340564
14	Nausea (HP:0002018)	4.14014904
15	Petechiae (HP:0000967)	3.92850447
16	Myocardial infarction (HP:0001658)	3.92311625
17	Xanthomatosis (HP:0000991)	3.89667686
18	Abnormal platelet volume (HP:0011876)	3.81017565
19	Epistaxis (HP:0000421)	3.80210929
20	Acanthocytosis (HP:0001927)	3.77187981
21	Abnormality of alanine metabolism (HP:0010916)	3.65506876
22	Hyperalaninemia (HP:0003348)	3.65506876
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.65506876
24	Hypobetalipoproteinemia (HP:0003563)	3.56175377
25	B lymphocytopenia (HP:0010976)	3.46021491
26	Retinal atrophy (HP:0001105)	3.39814134
27	Methylmalonic acidemia (HP:0002912)	3.22566395
28	Poikilocytosis (HP:0004447)	3.19000778
29	Abnormality of B cell number (HP:0010975)	3.09857469
30	Ectropion (HP:0000656)	2.91116001
31	Intestinal atresia (HP:0011100)	2.89447345
32	Purpura (HP:0000979)	2.87352971
33	Proximal tubulopathy (HP:0000114)	2.69748173
34	Joint swelling (HP:0001386)	2.66557242
35	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.64929569
36	Amyloidosis (HP:0011034)	2.55329457
37	Abnormality of vitamin B metabolism (HP:0004340)	2.50613003
38	Septo-optic dysplasia (HP:0100842)	2.47544044
39	Joint hemorrhage (HP:0005261)	2.46864274
40	Abnormality of serum amino acid levels (HP:0003112)	2.46418119
41	Hypercholesterolemia (HP:0003124)	2.45793327
42	Abnormality of methionine metabolism (HP:0010901)	2.45621571
43	3-Methylglutaconic aciduria (HP:0003535)	2.38670175
44	Abnormality of glycine metabolism (HP:0010895)	2.29692222
45	Abnormality of serine family amino acid metabolism (HP:0010894)	2.29692222
46	Paralysis (HP:0003470)	2.27423881
47	Abnormality of the renal cortex (HP:0011035)	2.25889164
48	Growth hormone deficiency (HP:0000824)	2.24230632
49	Gonadal dysgenesis (HP:0000133)	2.21170491
50	Hypophosphatemic rickets (HP:0004912)	2.20973372
51	Papillary thyroid carcinoma (HP:0002895)	2.20127154
52	Abnormal platelet function (HP:0011869)	2.17752987
53	Impaired platelet aggregation (HP:0003540)	2.17752987
54	Methylmalonic aciduria (HP:0012120)	2.17657047
55	Chorioretinal atrophy (HP:0000533)	2.14650094
56	Prolonged partial thromboplastin time (HP:0003645)	2.11921857
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11116216
58	Absent/shortened dynein arms (HP:0200106)	2.11116216
59	Glycosuria (HP:0003076)	2.10450472
60	Abnormality of urine glucose concentration (HP:0011016)	2.10450472
61	Abnormality of the ischium (HP:0003174)	2.08434758
62	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.08311205
63	Pancreatic islet-cell hyperplasia (HP:0004510)	2.06474158
64	Chronic hepatic failure (HP:0100626)	2.04860745
65	Febrile seizures (HP:0002373)	2.03876196
66	Disproportionate short-trunk short stature (HP:0003521)	2.02753471
67	Abnormal auditory evoked potentials (HP:0006958)	2.01377133
68	Male infertility (HP:0003251)	2.00583070
69	Polyphagia (HP:0002591)	2.00509782
70	Spastic paraparesis (HP:0002313)	2.00461413
71	Acute encephalopathy (HP:0006846)	2.00169610
72	Hyperglycinuria (HP:0003108)	1.98055940
73	Cupped ear (HP:0000378)	1.95312771
74	Abnormality of vitamin metabolism (HP:0100508)	1.94955407
75	Rhinitis (HP:0012384)	1.93851579
76	Abnormal pancreas size (HP:0012094)	1.92716072
77	Facial diplegia (HP:0001349)	1.92708381
78	Follicular hyperkeratosis (HP:0007502)	1.91342023
79	Severe Myopia (HP:0011003)	1.89023901
80	Hyperammonemia (HP:0001987)	1.88587201
81	Intrahepatic cholestasis (HP:0001406)	1.84256765
82	Optic nerve hypoplasia (HP:0000609)	1.81663095
83	Dysautonomia (HP:0002459)	1.81153204
84	Abnormal ciliary motility (HP:0012262)	1.80385092
85	Decreased muscle mass (HP:0003199)	1.78991987
86	Conjunctival telangiectasia (HP:0000524)	1.78505392
87	Hyperventilation (HP:0002883)	1.78369848
88	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.77919034
89	Concave nail (HP:0001598)	1.76953956
90	Curly hair (HP:0002212)	1.75218403
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75070141
92	Hypoglycemic coma (HP:0001325)	1.74559819
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.74422887
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74422887
95	Abnormal pupillary function (HP:0007686)	1.72164198
96	Abnormality of the nasal septum (HP:0000419)	1.66015346
97	Thyroid carcinoma (HP:0002890)	1.65824357
98	Absent eyebrow (HP:0002223)	1.65658827
99	Spontaneous hematomas (HP:0007420)	1.63860904
100	Bifid tongue (HP:0010297)	1.62546996

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	4.92360404
2	ADRBK2	4.21108433
3	MST4	3.92859827
4	TRIM28	3.49207591
5	ZAK	3.48849092
6	SIK3	3.30518510
7	TXK	3.16064365
8	WNK3	3.14468224
9	TNIK	2.67558706
10	MAPK13	2.33290946
11	SCYL2	2.33174813
12	PKN1	2.19031350
13	PAK3	2.07899964
14	PBK	1.93823675
15	MAP4K1	1.87951980
16	TLK1	1.67361089
17	PIK3CG	1.64487683
18	MYLK	1.64399238
19	AKT3	1.59918194
20	NUAK1	1.55727956
21	TYRO3	1.41270021
22	BMPR1B	1.33398207
23	BRSK2	1.33122161
24	EIF2AK3	1.22286015
25	EIF2AK1	1.21907722
26	BMX	1.21351931
27	MKNK2	1.14923095
28	BRD4	1.13178479
29	NLK	1.12812861
30	PTK2B	1.12587503
31	BCR	1.09737497
32	ACVR1B	1.08999569
33	TEC	1.07688581
34	MKNK1	1.07099819
35	NME1	1.06537007
36	FGFR2	1.06239655
37	STK3	1.05110968
38	FGFR3	1.03926441
39	WNK4	1.02755970
40	PLK2	0.95953778
41	GRK1	0.94963511
42	NEK9	0.94231374
43	PNCK	0.90964737
44	STK39	0.89679107
45	TAF1	0.88889638
46	LATS1	0.85897142
47	BCKDK	0.85143036
48	MARK3	0.83113612
49	KSR1	0.75518626
50	PLK3	0.73204930
51	PRKG1	0.72030185
52	ROCK1	0.71084834
53	ZAP70	0.69853349
54	TESK1	0.67764832
55	FGFR4	0.64211625
56	SRPK1	0.62725883
57	TESK2	0.60198113
58	MAP3K12	0.58454796
59	GRK5	0.58037174
60	PRKCE	0.57054656
61	FRK	0.54084772
62	NTRK2	0.53166995
63	BTK	0.51447423
64	FGR	0.50089564
65	CSF1R	0.48870213
66	SYK	0.48560898
67	STK4	0.47029941
68	PRKACG	0.46382911
69	MINK1	0.45576962
70	PRKACB	0.40072443
71	DYRK1A	0.39819510
72	HCK	0.39008332
73	LIMK1	0.37460109
74	NEK1	0.37436939
75	PDGFRB	0.37045793
76	CAMK2A	0.34967509
77	LMTK2	0.34298009
78	DAPK3	0.33259909
79	PRKCG	0.32104723
80	MAP3K10	0.32103623
81	MELK	0.31301697
82	PRKCB	0.30994320
83	PRKACA	0.30526676
84	ADRBK1	0.24917741
85	STK24	0.24328280
86	EPHB2	0.23525181
87	SGK2	0.23086046
88	CSNK1D	0.22743757
89	PRKCI	0.22467318
90	ERBB4	0.22377942
91	ILK	0.21950583
92	PRKCA	0.21109214
93	PAK1	0.20785577
94	INSR	0.20574738
95	WEE1	0.20238328
96	PAK2	0.20204759
97	CSNK2A1	0.20127768
98	PRKD1	0.19823926
99	FES	0.19046405
100	PDGFRA	0.18902732

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fat digestion and absorption_Homo sapiens_hsa04975	3.74635064
2	Sulfur metabolism_Homo sapiens_hsa00920	3.67593160
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.17651870
4	Nitrogen metabolism_Homo sapiens_hsa00910	3.14109265
5	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.06318722
6	Propanoate metabolism_Homo sapiens_hsa00640	2.57817112
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.57447192
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50869476
9	PPAR signaling pathway_Homo sapiens_hsa03320	2.39559755
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28751249
11	Fatty acid elongation_Homo sapiens_hsa00062	2.26842630
12	Platelet activation_Homo sapiens_hsa04611	2.25448815
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.05997756
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.94825621
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.91863768
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91680491
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.89820874
18	Complement and coagulation cascades_Homo sapiens_hsa04610	1.79592221
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.77504000
20	Glutathione metabolism_Homo sapiens_hsa00480	1.67226027
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66398285
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.65455303
23	Glycerolipid metabolism_Homo sapiens_hsa00561	1.63258485
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.58186686
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.51026026
26	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.47483487
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.42231769
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.39211835
29	Peroxisome_Homo sapiens_hsa04146	1.35093585
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32526175
31	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26591125
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24280832
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23906123
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23071604
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21424167
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19382265
37	Fatty acid degradation_Homo sapiens_hsa00071	1.18313657
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16996550
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.15488982
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14611220
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10839006
42	Pyruvate metabolism_Homo sapiens_hsa00620	1.02752456
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99291154
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99101808
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96807534
46	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93159294
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.92736175
48	Alcoholism_Homo sapiens_hsa05034	0.92528422
49	Butanoate metabolism_Homo sapiens_hsa00650	0.91496991
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91411482
51	ECM-receptor interaction_Homo sapiens_hsa04512	0.88898917
52	Basal transcription factors_Homo sapiens_hsa03022	0.87851382
53	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.86532793
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85300124
55	Retinol metabolism_Homo sapiens_hsa00830	0.81260141
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77612501
57	Caffeine metabolism_Homo sapiens_hsa00232	0.76854287
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75740637
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.73776676
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69250959
61	Other glycan degradation_Homo sapiens_hsa00511	0.67712798
62	Phototransduction_Homo sapiens_hsa04744	0.67304348
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.66855171
64	Carbon metabolism_Homo sapiens_hsa01200	0.62901668
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61472021
66	Serotonergic synapse_Homo sapiens_hsa04726	0.61445368
67	Galactose metabolism_Homo sapiens_hsa00052	0.60490930
68	Protein export_Homo sapiens_hsa03060	0.58342216
69	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55560809
70	Metabolic pathways_Homo sapiens_hsa01100	0.54395113
71	Olfactory transduction_Homo sapiens_hsa04740	0.48803746
72	ABC transporters_Homo sapiens_hsa02010	0.48284446
73	Proteasome_Homo sapiens_hsa03050	0.46021800
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44328013
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.42538423
76	African trypanosomiasis_Homo sapiens_hsa05143	0.42208863
77	Glucagon signaling pathway_Homo sapiens_hsa04922	0.40916555
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.40283033
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28774612
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.28717932
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.28675233
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.27089933
83	RNA degradation_Homo sapiens_hsa03018	0.27056219
84	One carbon pool by folate_Homo sapiens_hsa00670	0.26299889
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26087684
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25770876
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24878654
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23484575
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.22701541
90	Pancreatic secretion_Homo sapiens_hsa04972	0.22103483
91	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.21753032
92	Legionellosis_Homo sapiens_hsa05134	0.20990771
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.19887958
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.19670552
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.18512149
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.17551203
97	Parkinsons disease_Homo sapiens_hsa05012	0.16710113
98	Tight junction_Homo sapiens_hsa04530	0.15561570
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.15119879
100	Adherens junction_Homo sapiens_hsa04520	0.14576913

C1GALT1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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