ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	6.86544433
2	regulation of guanylate cyclase activity (GO:0031282)	6.69022692
3	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.41358281
4	angiotensin maturation (GO:0002003)	6.28392270
5	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	6.04954956
6	intestinal absorption (GO:0050892)	5.92745412
7	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.27974956
8	positive regulation of guanylate cyclase activity (GO:0031284)	5.23887854
9	vitamin transmembrane transport (GO:0035461)	4.69028679
10	uronic acid metabolic process (GO:0006063)	4.48700912
11	glucuronate metabolic process (GO:0019585)	4.48700912
12	epoxygenase P450 pathway (GO:0019373)	4.39742242
13	multicellular organismal water homeostasis (GO:0050891)	4.38814824
14	cellular glucuronidation (GO:0052695)	4.38641954
15	regulation of bile acid biosynthetic process (GO:0070857)	4.31126798
16	establishment of skin barrier (GO:0061436)	4.29440302
17	regulation of water loss via skin (GO:0033561)	4.27968916
18	digestion (GO:0007586)	4.20350104
19	hemidesmosome assembly (GO:0031581)	4.18112131
20	intestinal epithelial cell development (GO:0060576)	4.07278207
21	negative regulation of keratinocyte proliferation (GO:0010839)	3.98440117
22	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.95049562
23	endocrine process (GO:0050886)	3.95049562
24	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.95049562
25	regulation of cGMP biosynthetic process (GO:0030826)	3.91165638
26	renal system process involved in regulation of blood volume (GO:0001977)	3.89385052
27	fat-soluble vitamin biosynthetic process (GO:0042362)	3.86607034
28	drug metabolic process (GO:0017144)	3.86392090
29	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.85266356
30	regulation of keratinocyte proliferation (GO:0010837)	3.83171118
31	maintenance of gastrointestinal epithelium (GO:0030277)	3.80763078
32	primary alcohol catabolic process (GO:0034310)	3.79142437
33	O-glycan processing (GO:0016266)	3.77628913
34	flavonoid metabolic process (GO:0009812)	3.75424366
35	NADH metabolic process (GO:0006734)	3.75338964
36	negative regulation of epidermis development (GO:0045683)	3.75112875
37	regulation of systemic arterial blood pressure (GO:0003073)	3.72125958
38	negative regulation of epidermal cell differentiation (GO:0045605)	3.71199371
39	auditory receptor cell differentiation (GO:0042491)	3.68491976
40	positive regulation of pseudopodium assembly (GO:0031274)	3.67049307
41	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.59040666
42	bile acid and bile salt transport (GO:0015721)	3.55092136
43	water homeostasis (GO:0030104)	3.52896973
44	positive regulation of respiratory burst (GO:0060267)	3.45035982
45	vitamin transport (GO:0051180)	3.41495619
46	tight junction assembly (GO:0070830)	3.41156037
47	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.40773787
48	excretion (GO:0007588)	3.40077489
49	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.40050380
50	homocysteine metabolic process (GO:0050667)	3.38902154
51	regulation of cGMP metabolic process (GO:0030823)	3.38593466
52	regulation of cholesterol homeostasis (GO:2000188)	3.37670218
53	antibacterial humoral response (GO:0019731)	3.29743546
54	keratinocyte proliferation (GO:0043616)	3.28435291
55	sulfate transmembrane transport (GO:1902358)	3.27902742
56	ethanol oxidation (GO:0006069)	3.26516681
57	GDP-mannose metabolic process (GO:0019673)	3.26272856
58	antimicrobial humoral response (GO:0019730)	3.24558904
59	sulfur compound transport (GO:0072348)	3.22160370
60	ethanol metabolic process (GO:0006067)	3.19382309
61	cobalamin metabolic process (GO:0009235)	3.18850079
62	transepithelial transport (GO:0070633)	3.18713431
63	transcytosis (GO:0045056)	3.17470679
64	fucosylation (GO:0036065)	3.17310748
65	regulation of pseudopodium assembly (GO:0031272)	3.14807057
66	drug catabolic process (GO:0042737)	3.14529381
67	exogenous drug catabolic process (GO:0042738)	3.14155362
68	arginine metabolic process (GO:0006525)	3.13112772
69	regulation of cellular extravasation (GO:0002691)	3.13084745
70	digestive system process (GO:0022600)	3.10997026
71	oligosaccharide biosynthetic process (GO:0009312)	3.09345344
72	hormone catabolic process (GO:0042447)	3.08969852
73	gap junction assembly (GO:0016264)	3.07301702
74	nucleotide-sugar biosynthetic process (GO:0009226)	3.04306302
75	L-fucose metabolic process (GO:0042354)	3.04270317
76	L-fucose catabolic process (GO:0042355)	3.04270317
77	fucose catabolic process (GO:0019317)	3.04270317
78	positive regulation of glycoprotein metabolic process (GO:1903020)	3.01847533
79	epithelial cell-cell adhesion (GO:0090136)	3.01781717
80	sphingomyelin metabolic process (GO:0006684)	3.00572135
81	renal filtration (GO:0097205)	2.96955692
82	glutathione biosynthetic process (GO:0006750)	2.96692944
83	nonribosomal peptide biosynthetic process (GO:0019184)	2.90119496
84	positive regulation of cGMP biosynthetic process (GO:0030828)	2.87035623
85	kidney morphogenesis (GO:0060993)	2.84900786
86	diacylglycerol metabolic process (GO:0046339)	2.84205982
87	epithelial structure maintenance (GO:0010669)	2.83096017
88	lipoprotein transport (GO:0042953)	2.81902709
89	glomerular filtration (GO:0003094)	2.81169228
90	keratinization (GO:0031424)	2.80977548
91	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	2.80524891
92	drug transmembrane transport (GO:0006855)	2.77395031
93	urea cycle (GO:0000050)	2.76752857
94	regulation of keratinocyte differentiation (GO:0045616)	2.75350342
95	drug transport (GO:0015893)	2.75084021
96	primary alcohol metabolic process (GO:0034308)	2.74910424
97	regulation of vitamin metabolic process (GO:0030656)	2.74704866
98	sodium ion homeostasis (GO:0055078)	2.74645627
99	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.74216218
100	sulfate transport (GO:0008272)	2.73401466

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	7.61672876
2	* CDX2_20551321_ChIP-Seq_CACO-2_Human	4.89585958
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.03146706
4	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.35271855
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.27956015
6	GATA4_25053715_ChIP-Seq_YYC3_Human	3.25705871
7	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.12482673
8	* GATA6_25053715_ChIP-Seq_YYC3_Human	3.02258036
9	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.88062086
10	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.59614011
11	SOX2_20726797_ChIP-Seq_SW620_Human	2.56718986
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.42959397
13	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.27176262
14	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.18550780
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.08590548
16	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.06253104
17	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.97924850
18	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.89323229
19	* KLF5_25053715_ChIP-Seq_YYC3_Human	1.88622845
20	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.88616895
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.83885889
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.78355042
23	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.75864312
24	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.72174191
25	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.71308672
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.69266325
27	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.69091778
28	* TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.68427660
29	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.67805102
30	RACK7_27058665_Chip-Seq_MCF-7_Human	1.64873907
31	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.63972223
32	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.63359394
33	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.60147095
34	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.55393914
35	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.54301374
36	AR_21909140_ChIP-Seq_LNCAP_Human	1.53367870
37	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.52038128
38	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.48865364
39	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.47004002
40	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.45426942
41	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.37681366
42	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.35788284
43	* TCF4_18268006_ChIP-ChIP_LS174T_Human	1.35462164
44	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35369238
45	* TP63_22573176_ChIP-Seq_HFKS_Human	1.33900303
46	CTCF_27219007_Chip-Seq_Bcells_Human	1.33633639
47	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.27611477
48	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.26086439
49	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.22176601
50	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.20751422
51	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.19115044
52	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.19088206
53	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17164741
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.16371376
55	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.15770974
56	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.15770974
57	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.14148129
58	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.13852192
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12900932
60	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12771452
61	* SA1_27219007_Chip-Seq_Bcells_Human	1.11631923
62	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11316066
63	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.10503156
64	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.10416881
65	LXR_22292898_ChIP-Seq_THP-1_Human	1.08818404
66	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.07720745
67	ATF3_27146783_Chip-Seq_COLON_Human	1.06875225
68	* TP63_23658742_ChIP-Seq_EP156T_Human	1.04662861
69	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.03184817
70	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.03082334
71	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02972083
72	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.02967574
73	RXR_22108803_ChIP-Seq_LS180_Human	0.99965506
74	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.99592801
75	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.99397121
76	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.98342676
77	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96900936
78	BCOR_27268052_Chip-Seq_Bcells_Human	0.95358441
79	VDR_22108803_ChIP-Seq_LS180_Human	0.94802975
80	AHR_22903824_ChIP-Seq_MCF-7_Human	0.94214903
81	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.92826558
82	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91913762
83	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.91293943
84	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.89700502
85	PHF8_20622854_ChIP-Seq_HELA_Human	0.89213030
86	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.88679659
87	* E2F1_20622854_ChIP-Seq_HELA_Human	0.88589311
88	CREB1_26743006_Chip-Seq_LNCaP_Human	0.87479707
89	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.87184132
90	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.86975588
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85979526
92	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.84627065
93	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.83544569
94	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.83139338
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.81672302
96	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.80503642
97	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.80283560
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.80230124
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.79712143
100	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.78874262

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.87626525
2	MP0005360_urolithiasis	4.86831687
3	MP0000566_synostosis	3.93232422
4	MP0004264_abnormal_extraembryonic_tissu	3.92012560
5	MP0009379_abnormal_foot_pigmentation	3.61779486
6	MP0002139_abnormal_hepatobiliary_system	3.51141764
7	MP0002796_impaired_skin_barrier	3.49878222
8	MP0001666_abnormal_nutrient_absorption	3.31133165
9	MP0005085_abnormal_gallbladder_physiolo	3.05695560
10	MP0004019_abnormal_vitamin_homeostasis	2.72704367
11	MP0002098_abnormal_vibrissa_morphology	2.55419310
12	MP0005365_abnormal_bile_salt	2.49023126
13	MP0000579_abnormal_nail_morphology	2.46482038
14	MP0010678_abnormal_skin_adnexa	2.38355308
15	MP0010352_gastrointestinal_tract_polyps	2.28828193
16	MP0005501_abnormal_skin_physiology	2.18973489
17	MP0004043_abnormal_pH_regulation	2.18537684
18	MP0003941_abnormal_skin_development	2.11685404
19	MP0000537_abnormal_urethra_morphology	2.09349169
20	MP0003183_abnormal_peptide_metabolism	1.98035516
21	MP0001664_abnormal_digestion	1.94501336
22	MP0000490_abnormal_crypts_of	1.81890094
23	MP0000467_abnormal_esophagus_morphology	1.80194688
24	MP0004782_abnormal_surfactant_physiolog	1.78079898
25	MP0000383_abnormal_hair_follicle	1.76747986
26	MP0010155_abnormal_intestine_physiology	1.71594091
27	MP0003693_abnormal_embryo_hatching	1.71077801
28	MP0009840_abnormal_foam_cell	1.70491486
29	MP0000477_abnormal_intestine_morphology	1.69083354
30	MP0000678_abnormal_parathyroid_gland	1.62981430
31	MP0001216_abnormal_epidermal_layer	1.59747044
32	MP0005409_darkened_coat_color	1.50960622
33	MP0003866_abnormal_defecation	1.49013845
34	MP0008875_abnormal_xenobiotic_pharmacok	1.47821594
35	MP0004147_increased_porphyrin_level	1.44671985
36	MP0001188_hyperpigmentation	1.42729405
37	MP0009643_abnormal_urine_homeostasis	1.41020746
38	MP0003453_abnormal_keratinocyte_physiol	1.37085121
39	MP0001765_abnormal_ion_homeostasis	1.35425525
40	MP0000762_abnormal_tongue_morphology	1.34237524
41	MP0002876_abnormal_thyroid_physiology	1.32187064
42	MP0000462_abnormal_digestive_system	1.30345297
43	MP0001873_stomach_inflammation	1.27706142
44	MP0005332_abnormal_amino_acid	1.27386119
45	MP0003718_maternal_effect	1.26458683
46	MP0005670_abnormal_white_adipose	1.26246139
47	MP0001485_abnormal_pinna_reflex	1.26127032
48	MP0010329_abnormal_lipoprotein_level	1.23890006
49	MP0002138_abnormal_hepatobiliary_system	1.19427058
50	MP0008872_abnormal_physiological_respon	1.19085605
51	MP0001849_ear_inflammation	1.18807944
52	MP0000377_abnormal_hair_follicle	1.17965092
53	MP0003119_abnormal_digestive_system	1.12564913
54	MP0000538_abnormal_urinary_bladder	1.12041274
55	MP0010771_integument_phenotype	1.08592665
56	MP0003878_abnormal_ear_physiology	1.07133831
57	MP0005377_hearing/vestibular/ear_phenot	1.07133831
58	MP0002254_reproductive_system_inflammat	1.06463351
59	MP0002136_abnormal_kidney_physiology	1.04766081
60	MP0000427_abnormal_hair_cycle	1.01934565
61	MP0001663_abnormal_digestive_system	1.00532779
62	MP0005381_digestive/alimentary_phenotyp	1.00341337
63	MP0004858_abnormal_nervous_system	0.98249076
64	MP0003252_abnormal_bile_duct	0.96316416
65	MP0004957_abnormal_blastocyst_morpholog	0.96159632
66	MP0003315_abnormal_perineum_morphology	0.95964983
67	MP0005636_abnormal_mineral_homeostasis	0.95495027
68	MP0001756_abnormal_urination	0.93474362
69	MP0002089_abnormal_postnatal_growth/wei	0.90516438
70	MP0000470_abnormal_stomach_morphology	0.88971973
71	MP0010030_abnormal_orbit_morphology	0.82172854
72	MP0003868_abnormal_feces_composition	0.78926237
73	MP0002111_abnormal_tail_morphology	0.78794038
74	MP0003937_abnormal_limbs/digits/tail_de	0.77934501
75	MP0005083_abnormal_biliary_tract	0.77578662
76	MP0002233_abnormal_nose_morphology	0.77129542
77	MP0000516_abnormal_urinary_system	0.76953572
78	MP0005367_renal/urinary_system_phenotyp	0.76953572
79	MP0008789_abnormal_olfactory_epithelium	0.76605892
80	MP0003938_abnormal_ear_development	0.70879719
81	MP0002060_abnormal_skin_morphology	0.69042992
82	MP0002249_abnormal_larynx_morphology	0.68926410
83	MP0005023_abnormal_wound_healing	0.68343800
84	MP0001764_abnormal_homeostasis	0.66413317
85	MP0000647_abnormal_sebaceous_gland	0.65985419
86	MP0005166_decreased_susceptibility_to	0.63667207
87	MP0000627_abnormal_mammary_gland	0.63423833
88	MP0003638_abnormal_response/metabolism_	0.62697369
89	MP0004133_heterotaxia	0.60787827
90	MP0009053_abnormal_anal_canal	0.58902841
91	MP0002234_abnormal_pharynx_morphology	0.58643500
92	MP0001881_abnormal_mammary_gland	0.57381715
93	MP0003283_abnormal_digestive_organ	0.56818472
94	MP0002118_abnormal_lipid_homeostasis	0.56804265
95	MP0009931_abnormal_skin_appearance	0.55095857
96	MP0000367_abnormal_coat/_hair	0.52800278
97	MP0003755_abnormal_palate_morphology	0.51529891
98	MP0005394_taste/olfaction_phenotype	0.51408761
99	MP0005499_abnormal_olfactory_system	0.51408761
100	MP0001286_abnormal_eye_development	0.50605598

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.24172083
2	Hyperactive renin-angiotensin system (HP:0000841)	5.30335317
3	Right ventricular cardiomyopathy (HP:0011663)	4.89963776
4	Hydroxyprolinuria (HP:0003080)	4.70965856
5	Abnormality of proline metabolism (HP:0010907)	4.70965856
6	Malnutrition (HP:0004395)	4.54509716
7	Pili torti (HP:0003777)	4.46485690
8	Decreased circulating renin level (HP:0003351)	4.24375890
9	Abnormality of renin-angiotensin system (HP:0000847)	3.68583487
10	Chronic bronchitis (HP:0004469)	3.64841782
11	Plantar hyperkeratosis (HP:0007556)	3.62425591
12	Abnormal hair laboratory examination (HP:0003328)	3.56018153
13	Hyperglycinuria (HP:0003108)	3.32771907
14	Fragile nails (HP:0001808)	3.29532778
15	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.27563026
16	Palmoplantar hyperkeratosis (HP:0000972)	3.07607303
17	Woolly hair (HP:0002224)	3.07403182
18	Abnormality of vitamin B metabolism (HP:0004340)	3.06975358
19	Ileus (HP:0002595)	3.06823582
20	Metabolic alkalosis (HP:0200114)	3.01712145
21	Confusion (HP:0001289)	2.97844525
22	Abnormality of chloride homeostasis (HP:0011422)	2.94975162
23	Palmar hyperkeratosis (HP:0010765)	2.92027340
24	Alkalosis (HP:0001948)	2.89598750
25	Focal segmental glomerulosclerosis (HP:0000097)	2.87368230
26	Abnormality of serine family amino acid metabolism (HP:0010894)	2.86704031
27	Abnormality of glycine metabolism (HP:0010895)	2.86704031
28	Milia (HP:0001056)	2.82537727
29	Widely patent fontanelles and sutures (HP:0004492)	2.82523372
30	Alopecia of scalp (HP:0002293)	2.76010393
31	Flat acetabular roof (HP:0003180)	2.75825007
32	Fat malabsorption (HP:0002630)	2.68553923
33	Hyperuricemia (HP:0002149)	2.68382974
34	Increased purine levels (HP:0004368)	2.68382974
35	Abnormality of vitamin metabolism (HP:0100508)	2.67875580
36	Hyperaldosteronism (HP:0000859)	2.67377095
37	Onycholysis (HP:0001806)	2.62930927
38	Abnormality of nail color (HP:0100643)	2.58019808
39	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.52093433
40	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.49100705
41	Chronic diarrhea (HP:0002028)	2.46883892
42	Glomerulosclerosis (HP:0000096)	2.45613029
43	Gout (HP:0001997)	2.41855564
44	Dehydration (HP:0001944)	2.41281072
45	Hypobetalipoproteinemia (HP:0003563)	2.37631169
46	Hypotrichosis (HP:0001006)	2.37526073
47	Abdominal distention (HP:0003270)	2.36510782
48	Abnormality of urine glucose concentration (HP:0011016)	2.35494825
49	Glycosuria (HP:0003076)	2.35494825
50	Amelogenesis imperfecta (HP:0000705)	2.31181192
51	Pterygium (HP:0001059)	2.27099407
52	Congenital sensorineural hearing impairment (HP:0008527)	2.23996847
53	Abnormal tarsal ossification (HP:0008369)	2.17702856
54	Hyperkalemia (HP:0002153)	2.17326550
55	Abnormal pancreas size (HP:0012094)	2.12510591
56	Delayed epiphyseal ossification (HP:0002663)	2.12354851
57	Abnormality of small intestinal villus morphology (HP:0011472)	2.12070389
58	Villous atrophy (HP:0011473)	2.12070389
59	Pigmentary retinal degeneration (HP:0001146)	2.11154646
60	Abnormal biliary tract morphology (HP:0012440)	2.10294352
61	Bronchomalacia (HP:0002780)	2.08998981
62	Hyponatremia (HP:0002902)	2.06578008
63	Curly hair (HP:0002212)	2.03895889
64	Bronchiectasis (HP:0002110)	2.03183774
65	Hypoplasia of the uterus (HP:0000013)	2.02722022
66	Sparse eyelashes (HP:0000653)	1.99799973
67	Popliteal pterygium (HP:0009756)	1.98410155
68	Renal salt wasting (HP:0000127)	1.96929662
69	Hypoplastic labia majora (HP:0000059)	1.96459086
70	Abnormality of purine metabolism (HP:0004352)	1.95113925
71	Abnormality of the gastric mucosa (HP:0004295)	1.94315863
72	Flattened epiphyses (HP:0003071)	1.93826874
73	Tubular atrophy (HP:0000092)	1.93611461
74	Intrahepatic cholestasis (HP:0001406)	1.92280503
75	Late onset (HP:0003584)	1.90215219
76	Nephrolithiasis (HP:0000787)	1.88454084
77	Rhinitis (HP:0012384)	1.86705272
78	Acanthocytosis (HP:0001927)	1.86615603
79	Abnormality of the salivary glands (HP:0010286)	1.85008885
80	Wide cranial sutures (HP:0010537)	1.84224221
81	Proximal tubulopathy (HP:0000114)	1.81887284
82	Congenital ichthyosiform erythroderma (HP:0007431)	1.81673982
83	Abnormality of nucleobase metabolism (HP:0010932)	1.81191333
84	Hypoplasia of dental enamel (HP:0006297)	1.81068696
85	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79878615
86	Abnormality of magnesium homeostasis (HP:0004921)	1.79807786
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.78640726
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78640726
89	Abnormality of potassium homeostasis (HP:0011042)	1.76895854
90	Megaloblastic anemia (HP:0001889)	1.76330603
91	Biliary tract neoplasm (HP:0100574)	1.76097856
92	Potter facies (HP:0002009)	1.75997277
93	Facial shape deformation (HP:0011334)	1.75997277
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74664139
95	Abnormality of permanent molar morphology (HP:0011071)	1.74300885
96	Abnormality of the dental root (HP:0006486)	1.74300885
97	Taurodontia (HP:0000679)	1.74300885
98	Steatorrhea (HP:0002570)	1.74277157
99	Ridged nail (HP:0001807)	1.73657978
100	Conjugated hyperbilirubinemia (HP:0002908)	1.72370450

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	7.60726352
2	MST1R	6.80035063
3	ACVR1B	3.94900878
4	LMTK2	3.62766763
5	MET	3.11414246
6	STK24	2.63987067
7	MST4	2.53301413
8	EPHB2	2.51486162
9	STK39	2.41681269
10	MAP3K10	2.34408668
11	RIPK1	2.15516737
12	OXSR1	1.97214090
13	ERN1	1.87213787
14	PRKG2	1.85608099
15	NME1	1.77201795
16	TNIK	1.65197358
17	PIK3CA	1.43982844
18	SMG1	1.43310569
19	STK38L	1.38992202
20	PTK6	1.38944921
21	MAPK15	1.31310464
22	FER	1.22426298
23	MAP3K2	1.13364296
24	GRK1	1.11860190
25	TTK	1.07374566
26	FGFR4	1.05269764
27	PAK4	1.01207234
28	WNK4	0.99178491
29	MAP2K2	0.98871160
30	PRKCI	0.98521271
31	MAPKAPK3	0.97944770
32	ERBB2	0.97121528
33	PTK2	0.93034419
34	MAP3K12	0.88679381
35	FRK	0.85569881
36	NEK1	0.81885327
37	MATK	0.79626130
38	STK3	0.79434436
39	LATS1	0.79195074
40	EEF2K	0.78872538
41	EPHA4	0.77503638
42	BCR	0.77428219
43	MKNK2	0.74537048
44	RPS6KB2	0.73948324
45	NLK	0.73718682
46	SIK1	0.71025418
47	ZAK	0.70264662
48	TGFBR1	0.68671707
49	TLK1	0.68026965
50	CDK19	0.63568092
51	VRK2	0.61172034
52	FGFR1	0.60893582
53	BMPR1B	0.60227835
54	MKNK1	0.59994754
55	CASK	0.59536013
56	PBK	0.58518353
57	BMX	0.58165159
58	MAP2K6	0.56342525
59	TRIM28	0.52511774
60	ADRBK2	0.50002579
61	DDR2	0.47065571
62	EPHB1	0.47012195
63	MELK	0.43923281
64	BRSK2	0.43804717
65	CSNK1A1	0.39678665
66	INSRR	0.38910783
67	PRKAA2	0.38511708
68	NUAK1	0.36856431
69	NEK2	0.36790200
70	MAP3K9	0.36755250
71	FGFR2	0.35923077
72	IRAK1	0.33854638
73	WNK3	0.33233778
74	PRKCZ	0.31944030
75	PRKCE	0.28153914
76	PRKCA	0.27943556
77	FGFR3	0.27001286
78	CDC42BPA	0.26810445
79	PDK2	0.26313765
80	PRKCD	0.23427173
81	SRC	0.23220593
82	AURKB	0.22837642
83	CDK8	0.22589904
84	TAF1	0.22577504
85	CHUK	0.21561466
86	PLK1	0.21014979
87	IGF1R	0.20448158
88	PASK	0.19166069
89	PLK4	0.19115309
90	MAPKAPK5	0.18025696
91	MAP3K3	0.17384166
92	CDK9	0.16523572
93	PRKCQ	0.15153227
94	MAP3K7	0.14393149
95	CSNK1E	0.13501180
96	MAPK11	0.13141665
97	MAP2K1	0.12635592
98	DYRK2	0.11928900
99	FLT3	0.09694989
100	MAP3K8	0.09474607

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.00674202
2	Fat digestion and absorption_Homo sapiens_hsa04975	3.98621240
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.49343413
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.93449674
5	Renin-angiotensin system_Homo sapiens_hsa04614	2.76992890
6	Histidine metabolism_Homo sapiens_hsa00340	2.68610622
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.61073728
8	Sulfur metabolism_Homo sapiens_hsa00920	2.55759207
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.52364315
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.38264738
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38078210
12	Arginine biosynthesis_Homo sapiens_hsa00220	2.19562549
13	Mineral absorption_Homo sapiens_hsa04978	2.19148640
14	Retinol metabolism_Homo sapiens_hsa00830	2.14862117
15	Protein digestion and absorption_Homo sapiens_hsa04974	2.12262719
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07446553
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.06936138
18	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.00968851
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.99622043
20	Caffeine metabolism_Homo sapiens_hsa00232	1.98822958
21	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.94578253
22	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.89522855
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.88693376
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64791372
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.64779689
26	Galactose metabolism_Homo sapiens_hsa00052	1.62405488
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.56043408
28	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.52779634
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.50974947
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.50237530
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.49618015
32	Bile secretion_Homo sapiens_hsa04976	1.43679258
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.37985886
34	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.33195258
35	Fatty acid degradation_Homo sapiens_hsa00071	1.31390528
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.24769203
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.19299382
38	Glutathione metabolism_Homo sapiens_hsa00480	1.18147451
39	Tight junction_Homo sapiens_hsa04530	1.17795720
40	PPAR signaling pathway_Homo sapiens_hsa03320	1.16799884
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.11540432
42	Sphingolipid metabolism_Homo sapiens_hsa00600	1.10797449
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10178838
44	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09577913
45	Pancreatic secretion_Homo sapiens_hsa04972	1.09476277
46	Sulfur relay system_Homo sapiens_hsa04122	1.08073879
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05159090
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.04093668
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02647795
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.00008896
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85483230
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68296385
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.62570871
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.61688758
55	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60309750
56	Peroxisome_Homo sapiens_hsa04146	0.58143718
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.56829379
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56799731
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56746764
60	Butanoate metabolism_Homo sapiens_hsa00650	0.55368780
61	Metabolic pathways_Homo sapiens_hsa01100	0.52199130
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51316107
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.51171393
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.49560272
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.48285420
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48168284
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.46792350
68	ABC transporters_Homo sapiens_hsa02010	0.41827340
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41620819
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39922636
71	Hepatitis C_Homo sapiens_hsa05160	0.38933508
72	Propanoate metabolism_Homo sapiens_hsa00640	0.37864073
73	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.36468776
74	Adherens junction_Homo sapiens_hsa04520	0.34680806
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.33014402
76	Asthma_Homo sapiens_hsa05310	0.30060467
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28839794
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.28164508
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27402233
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26071719
81	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.25059930
82	Phototransduction_Homo sapiens_hsa04744	0.24696383
83	Carbon metabolism_Homo sapiens_hsa01200	0.22784072
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.21874344
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.18673899
86	Pentose phosphate pathway_Homo sapiens_hsa00030	0.15735197
87	Folate biosynthesis_Homo sapiens_hsa00790	0.15145689
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.14829795
89	Fatty acid elongation_Homo sapiens_hsa00062	0.14359980
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.14024786
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.11454906
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.11425604
93	Notch signaling pathway_Homo sapiens_hsa04330	0.08889782
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.08460196
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.06491237
96	Insulin resistance_Homo sapiens_hsa04931	0.06472133
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.06232090
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.03796156
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.02312769
100	Thyroid cancer_Homo sapiens_hsa05216	0.01401818

C1ORF106

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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