C1ORF109

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.23900933
2pseudouridine synthesis (GO:0001522)4.06942924
3DNA replication checkpoint (GO:0000076)3.88838393
4establishment of protein localization to mitochondrial membrane (GO:0090151)3.73610115
5chromatin remodeling at centromere (GO:0031055)3.72765412
6protein-cofactor linkage (GO:0018065)3.59480246
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57956166
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.57956166
9NADH dehydrogenase complex assembly (GO:0010257)3.57956166
10mitochondrial respiratory chain complex assembly (GO:0033108)3.57831769
11CENP-A containing nucleosome assembly (GO:0034080)3.57420611
12cullin deneddylation (GO:0010388)3.51109804
13protein complex biogenesis (GO:0070271)3.50827282
14protein deneddylation (GO:0000338)3.48123415
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45592735
16protein K6-linked ubiquitination (GO:0085020)3.44587982
17mitochondrial RNA metabolic process (GO:0000959)3.43031673
18maturation of 5.8S rRNA (GO:0000460)3.41601025
19DNA strand elongation involved in DNA replication (GO:0006271)3.38752498
20nucleobase biosynthetic process (GO:0046112)3.33372194
21chaperone-mediated protein transport (GO:0072321)3.33366467
22replication fork processing (GO:0031297)3.31963356
23purine nucleobase biosynthetic process (GO:0009113)3.29855769
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28816385
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28370738
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26230992
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26230992
28DNA strand elongation (GO:0022616)3.26072675
29DNA deamination (GO:0045006)3.25669942
30rRNA modification (GO:0000154)3.24372670
31termination of RNA polymerase III transcription (GO:0006386)3.23858524
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.23858524
33DNA damage response, detection of DNA damage (GO:0042769)3.23695576
34regulation of mitochondrial translation (GO:0070129)3.21121309
35ribosome biogenesis (GO:0042254)3.20488115
36ATP synthesis coupled proton transport (GO:0015986)3.19456612
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19456612
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.15600020
39DNA double-strand break processing (GO:0000729)3.14611736
40respiratory chain complex IV assembly (GO:0008535)3.13733437
41histone exchange (GO:0043486)3.13722851
42rRNA processing (GO:0006364)3.13536861
43tRNA processing (GO:0008033)3.12172272
44water-soluble vitamin biosynthetic process (GO:0042364)3.11383966
45spliceosomal snRNP assembly (GO:0000387)3.09833771
46transcription from mitochondrial promoter (GO:0006390)3.07745655
47telomere maintenance via semi-conservative replication (GO:0032201)3.06997572
48L-serine metabolic process (GO:0006563)3.06413177
49rRNA metabolic process (GO:0016072)3.04928330
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03260315
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.03260315
52maturation of SSU-rRNA (GO:0030490)3.02972165
53DNA catabolic process, exonucleolytic (GO:0000738)3.01758842
54tRNA metabolic process (GO:0006399)3.01048179
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00570903
56regulation of mitotic spindle checkpoint (GO:1903504)2.98693082
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98693082
58peptidyl-histidine modification (GO:0018202)2.98178349
59DNA replication-dependent nucleosome assembly (GO:0006335)2.97549457
60DNA replication-dependent nucleosome organization (GO:0034723)2.97549457
61mitotic metaphase plate congression (GO:0007080)2.97277882
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96059533
63mitotic sister chromatid segregation (GO:0000070)2.95911576
64ribosome assembly (GO:0042255)2.95388396
65cellular component biogenesis (GO:0044085)2.91451741
66IMP biosynthetic process (GO:0006188)2.86566893
67protein localization to kinetochore (GO:0034501)2.86149698
68ncRNA metabolic process (GO:0034660)2.85723049
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85184240
70ncRNA processing (GO:0034470)2.83822444
71DNA replication-independent nucleosome assembly (GO:0006336)2.83345886
72DNA replication-independent nucleosome organization (GO:0034724)2.83345886
73ribonucleoprotein complex biogenesis (GO:0022613)2.83284982
74amino acid activation (GO:0043038)2.83262029
75tRNA aminoacylation (GO:0043039)2.83262029
76tRNA aminoacylation for protein translation (GO:0006418)2.80836028
77tRNA modification (GO:0006400)2.79729160
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79054059
79regulation of centriole replication (GO:0046599)2.78894871
80postreplication repair (GO:0006301)2.78660341
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76658769
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75780617
83rRNA methylation (GO:0031167)2.75736001
84sister chromatid segregation (GO:0000819)2.74623686
85folic acid-containing compound biosynthetic process (GO:0009396)2.72231490
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71652409
87protein targeting to mitochondrion (GO:0006626)2.70441194
88meiotic chromosome segregation (GO:0045132)2.69903969
89negative regulation of ligase activity (GO:0051352)2.69576669
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69576669
91tRNA methylation (GO:0030488)2.68610910
92cytochrome complex assembly (GO:0017004)2.67375882
93kinetochore organization (GO:0051383)2.65465436
94recombinational repair (GO:0000725)2.64776860
95electron transport chain (GO:0022900)2.64147163
96DNA ligation (GO:0006266)2.64080433
97double-strand break repair via homologous recombination (GO:0000724)2.63015992
98establishment of protein localization to mitochondrion (GO:0072655)2.63011866
99respiratory electron transport chain (GO:0022904)2.62541822
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.62204412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91538985
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88246572
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21605979
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.82583612
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.59477378
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53754547
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53416313
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.21481319
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14762909
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07305183
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94479937
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78504301
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.73310675
14* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71425435
15* VDR_23849224_ChIP-Seq_CD4+_Human2.59291028
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59184847
17ELK1_19687146_ChIP-ChIP_HELA_Human2.56292847
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50469065
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47023419
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43977412
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43119374
22FOXP3_21729870_ChIP-Seq_TREG_Human2.41233019
23TTF2_22483619_ChIP-Seq_HELA_Human2.26514440
24* XRN2_22483619_ChIP-Seq_HELA_Human2.16621876
25DCP1A_22483619_ChIP-Seq_HELA_Human2.14890794
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14170024
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14088902
28ZNF274_21170338_ChIP-Seq_K562_Hela2.10521692
29* GABP_19822575_ChIP-Seq_HepG2_Human2.10026555
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03994334
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02811616
32MYC_18940864_ChIP-ChIP_HL60_Human2.01277873
33* NOTCH1_21737748_ChIP-Seq_TLL_Human1.97538206
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96654212
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96561746
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.93178279
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86997093
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86988137
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84834489
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83912895
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.79175125
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77484782
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.77137916
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73735327
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64545752
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62455126
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60887904
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60814520
49* KDM5A_27292631_Chip-Seq_BREAST_Human1.59717808
50EWS_26573619_Chip-Seq_HEK293_Human1.57392571
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55035406
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45756020
53VDR_22108803_ChIP-Seq_LS180_Human1.44595057
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43229413
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.39945316
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36521682
57AR_21909140_ChIP-Seq_LNCAP_Human1.25229327
58IRF1_19129219_ChIP-ChIP_H3396_Human1.23712784
59* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23057099
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17641769
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.14766449
62FUS_26573619_Chip-Seq_HEK293_Human1.14120020
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13521000
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13143624
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11035392
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10993752
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10516098
68IGF1R_20145208_ChIP-Seq_DFB_Human1.10380543
69CIITA_25753668_ChIP-Seq_RAJI_Human1.06700091
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06351558
71TP53_22573176_ChIP-Seq_HFKS_Human1.04442101
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01090384
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.98290729
74ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98260804
75NANOG_16153702_ChIP-ChIP_HESCs_Human0.97955790
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95305496
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91733207
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91702927
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91134732
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90177148
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.90045926
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89470339
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.88538671
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86272941
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84842101
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82419685
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79275327
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75397588
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75297549
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73840569
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73626085
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71898985
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69232257
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68876491
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.68852096
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68742478
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67225583
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67030922
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66990404
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.66990404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96329706
2MP0008058_abnormal_DNA_repair3.90037107
3MP0010094_abnormal_chromosome_stability3.75735908
4MP0003111_abnormal_nucleus_morphology3.18851489
5MP0004957_abnormal_blastocyst_morpholog3.03825007
6MP0006292_abnormal_olfactory_placode2.80342507
7MP0008877_abnormal_DNA_methylation2.77994576
8MP0004147_increased_porphyrin_level2.70719648
9MP0008057_abnormal_DNA_replication2.68063896
10MP0003077_abnormal_cell_cycle2.59849123
11MP0002102_abnormal_ear_morphology2.48686750
12MP0008932_abnormal_embryonic_tissue2.19985411
13MP0008007_abnormal_cellular_replicative2.17010785
14MP0003718_maternal_effect2.04631891
15MP0003786_premature_aging1.96462852
16MP0002938_white_spotting1.82655570
17MP0006035_abnormal_mitochondrial_morpho1.72654897
18MP0006072_abnormal_retinal_apoptosis1.68230501
19MP0003937_abnormal_limbs/digits/tail_de1.61144245
20MP0001529_abnormal_vocalization1.59634820
21MP0009697_abnormal_copulation1.47078235
22MP0002163_abnormal_gland_morphology1.41635283
23MP0008789_abnormal_olfactory_epithelium1.41452948
24MP0003186_abnormal_redox_activity1.39143335
25MP0006036_abnormal_mitochondrial_physio1.38619580
26MP0003136_yellow_coat_color1.37637728
27MP0000049_abnormal_middle_ear1.37511292
28MP0000372_irregular_coat_pigmentation1.37144978
29MP0002210_abnormal_sex_determination1.36487560
30MP0001293_anophthalmia1.35406563
31MP0005551_abnormal_eye_electrophysiolog1.33559797
32MP0002653_abnormal_ependyma_morphology1.33186108
33MP0008995_early_reproductive_senescence1.31873891
34MP0004133_heterotaxia1.30207553
35MP0003567_abnormal_fetal_cardiomyocyte1.27472586
36MP0002638_abnormal_pupillary_reflex1.25853144
37MP0001188_hyperpigmentation1.25261491
38MP0001929_abnormal_gametogenesis1.25044490
39MP0002736_abnormal_nociception_after1.25034865
40MP0003121_genomic_imprinting1.23511309
41MP0003122_maternal_imprinting1.23065541
42MP0002234_abnormal_pharynx_morphology1.22643833
43MP0002160_abnormal_reproductive_system1.21272060
44MP0001968_abnormal_touch/_nociception1.20856369
45MP0005253_abnormal_eye_physiology1.20781319
46MP0005645_abnormal_hypothalamus_physiol1.16693443
47MP0001697_abnormal_embryo_size1.13906977
48MP0003806_abnormal_nucleotide_metabolis1.13291774
49MP0001145_abnormal_male_reproductive1.11997625
50MP0001984_abnormal_olfaction1.10723258
51MP0003195_calcinosis1.10645234
52MP0003890_abnormal_embryonic-extraembry1.07938966
53MP0000631_abnormal_neuroendocrine_gland1.07561639
54MP0000358_abnormal_cell_content/1.05322064
55MP0000653_abnormal_sex_gland1.04734085
56MP0000350_abnormal_cell_proliferation1.04115641
57MP0003787_abnormal_imprinting1.01070536
58MP0003698_abnormal_male_reproductive0.98805233
59MP0005379_endocrine/exocrine_gland_phen0.98404551
60MP0000647_abnormal_sebaceous_gland0.95426847
61MP0002085_abnormal_embryonic_tissue0.94760797
62MP0002751_abnormal_autonomic_nervous0.94135242
63MP0001286_abnormal_eye_development0.93042336
64MP0005394_taste/olfaction_phenotype0.92870807
65MP0005499_abnormal_olfactory_system0.92870807
66MP0008872_abnormal_physiological_respon0.92281673
67MP0001661_extended_life_span0.92093129
68MP0003880_abnormal_central_pattern0.91762919
69MP0001672_abnormal_embryogenesis/_devel0.91695230
70MP0005380_embryogenesis_phenotype0.91695230
71MP0002837_dystrophic_cardiac_calcinosis0.90053713
72MP0002084_abnormal_developmental_patter0.89999815
73MP0001730_embryonic_growth_arrest0.89653784
74MP0004142_abnormal_muscle_tone0.89559601
75MP0009046_muscle_twitch0.89122952
76MP0003646_muscle_fatigue0.87956194
77MP0002233_abnormal_nose_morphology0.87840508
78MP0006276_abnormal_autonomic_nervous0.87699589
79MP0003119_abnormal_digestive_system0.87576025
80MP0001764_abnormal_homeostasis0.86559553
81MP0000313_abnormal_cell_death0.85829035
82MP0005084_abnormal_gallbladder_morpholo0.84763008
83MP0005389_reproductive_system_phenotype0.84234165
84MP0001727_abnormal_embryo_implantation0.82926765
85MP0002111_abnormal_tail_morphology0.82475095
86MP0003011_delayed_dark_adaptation0.81373541
87MP0010307_abnormal_tumor_latency0.81089385
88MP0003755_abnormal_palate_morphology0.79080355
89MP0002080_prenatal_lethality0.78823234
90MP0002095_abnormal_skin_pigmentation0.78076553
91MP0004197_abnormal_fetal_growth/weight/0.77719578
92MP0005195_abnormal_posterior_eye0.76319940
93MP0005391_vision/eye_phenotype0.76280142
94MP0000427_abnormal_hair_cycle0.74919240
95MP0003861_abnormal_nervous_system0.74643918
96MP0002088_abnormal_embryonic_growth/wei0.73870677
97MP0002697_abnormal_eye_size0.73450573
98MP0008875_abnormal_xenobiotic_pharmacok0.72774257
99MP0001324_abnormal_eye_pigmentation0.71353554
100MP0001119_abnormal_female_reproductive0.70778485

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.66129531
2Acute necrotizing encephalopathy (HP:0006965)3.44963848
3Abnormality of the labia minora (HP:0012880)3.25162274
4Abnormal mitochondria in muscle tissue (HP:0008316)3.24352754
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22810675
6Acute encephalopathy (HP:0006846)3.17208902
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15319954
8Abnormality of alanine metabolism (HP:0010916)3.15319954
9Hyperalaninemia (HP:0003348)3.15319954
10Increased CSF lactate (HP:0002490)3.06100397
11Chromsome breakage (HP:0040012)3.00661654
12Mitochondrial inheritance (HP:0001427)2.95849873
13Hypoplasia of the pons (HP:0012110)2.91880571
14Abnormality of the pons (HP:0007361)2.87453374
15Meckel diverticulum (HP:0002245)2.84232744
16Pancreatic cysts (HP:0001737)2.80245641
17Abnormality of the ileum (HP:0001549)2.77148753
18Progressive macrocephaly (HP:0004481)2.76549608
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.74282512
20Lipid accumulation in hepatocytes (HP:0006561)2.73453401
21Abnormal number of erythroid precursors (HP:0012131)2.69328952
22Type II lissencephaly (HP:0007260)2.67126854
23Increased hepatocellular lipid droplets (HP:0006565)2.66932506
24Increased serum lactate (HP:0002151)2.64029470
25Reticulocytopenia (HP:0001896)2.56788881
26Hepatocellular necrosis (HP:0001404)2.50838931
27Pancreatic fibrosis (HP:0100732)2.45785538
28Abnormality of cells of the erythroid lineage (HP:0012130)2.45353903
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39638365
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39638365
31Hepatic necrosis (HP:0002605)2.36501008
32Patellar aplasia (HP:0006443)2.35227790
33Abnormality of the preputium (HP:0100587)2.34365257
34Abnormality of chromosome stability (HP:0003220)2.32393283
35Aplasia/Hypoplasia of the patella (HP:0006498)2.32076223
36Cerebral edema (HP:0002181)2.31101113
37Type I transferrin isoform profile (HP:0003642)2.31001875
38Pendular nystagmus (HP:0012043)2.29426914
39Lactic acidosis (HP:0003128)2.29030308
403-Methylglutaconic aciduria (HP:0003535)2.25844864
41Methylmalonic acidemia (HP:0002912)2.23934792
42Abnormality of midbrain morphology (HP:0002418)2.23876492
43Molar tooth sign on MRI (HP:0002419)2.23876492
44Abnormal protein glycosylation (HP:0012346)2.23182107
45Abnormal glycosylation (HP:0012345)2.23182107
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23182107
47Abnormal protein N-linked glycosylation (HP:0012347)2.23182107
48Congenital stationary night blindness (HP:0007642)2.20055185
49True hermaphroditism (HP:0010459)2.19749667
50Cerebellar dysplasia (HP:0007033)2.19514766
51Horseshoe kidney (HP:0000085)2.18704046
52Lissencephaly (HP:0001339)2.18530051
53Abnormality of homocysteine metabolism (HP:0010919)2.17189536
54Homocystinuria (HP:0002156)2.17189536
55Absent thumb (HP:0009777)2.12316274
56Colon cancer (HP:0003003)2.10526374
57Small intestinal stenosis (HP:0012848)2.09849926
58Duodenal stenosis (HP:0100867)2.09849926
59Duplicated collecting system (HP:0000081)2.02880136
60Methylmalonic aciduria (HP:0012120)2.02633992
61Ectopic kidney (HP:0000086)1.99607778
62Medial flaring of the eyebrow (HP:0010747)1.98243002
63Increased intramyocellular lipid droplets (HP:0012240)1.97908835
64Sloping forehead (HP:0000340)1.96397555
65Abnormality of the renal collecting system (HP:0004742)1.94981195
66Optic disc pallor (HP:0000543)1.91825146
67Macrocytic anemia (HP:0001972)1.91391477
68Abnormal lung lobation (HP:0002101)1.90327330
69Abnormality of the duodenum (HP:0002246)1.87882181
70Abnormality of serum amino acid levels (HP:0003112)1.87263533
71Pancytopenia (HP:0001876)1.86608085
72Abnormality of the carotid arteries (HP:0005344)1.86080685
73Abnormality of methionine metabolism (HP:0010901)1.83684632
74Abnormality of DNA repair (HP:0003254)1.80838565
75Cerebral hypomyelination (HP:0006808)1.80561302
76Sclerocornea (HP:0000647)1.79131266
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76874975
78Lethargy (HP:0001254)1.76386228
79Progressive microcephaly (HP:0000253)1.75916835
80Aplasia involving forearm bones (HP:0009822)1.75660558
81Absent forearm bone (HP:0003953)1.75660558
82Nephronophthisis (HP:0000090)1.74288666
83Congenital primary aphakia (HP:0007707)1.73629124
84Retinal dysplasia (HP:0007973)1.72822390
85Triphalangeal thumb (HP:0001199)1.72224756
86Dandy-Walker malformation (HP:0001305)1.71590052
87Renal Fanconi syndrome (HP:0001994)1.70752685
88Absent radius (HP:0003974)1.70399308
89Respiratory failure (HP:0002878)1.70142023
90Abolished electroretinogram (ERG) (HP:0000550)1.69274401
91Leukodystrophy (HP:0002415)1.69018269
92Neoplasm of the adrenal gland (HP:0100631)1.68296725
93Pallor (HP:0000980)1.67992778
94Gait imbalance (HP:0002141)1.65894963
95Increased muscle lipid content (HP:0009058)1.64010337
96Renal cortical cysts (HP:0000803)1.63289899
97Carpal bone hypoplasia (HP:0001498)1.62932140
98Microretrognathia (HP:0000308)1.62633689
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62334770
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62061444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85974504
2SRPK13.18014272
3TSSK63.12173102
4ZAK3.04216949
5CDC72.69075419
6VRK22.65611665
7NEK12.49364040
8BMPR1B2.35800088
9TTK2.33999959
10PBK2.28349216
11EIF2AK12.11176818
12NUAK12.04576274
13TLK12.03802194
14WEE12.01640900
15TRIM281.97204349
16PLK31.94100938
17MKNK21.93374722
18MAP4K21.91101709
19EIF2AK31.90411319
20STK161.79070791
21PLK41.77406288
22VRK11.75412159
23WNK31.74234720
24ADRBK21.73528936
25NME11.66584848
26PLK11.59036375
27MKNK11.56272160
28MST41.51373943
29BRSK21.48983777
30TAF11.48317719
31CHEK21.45590537
32PNCK1.44547047
33ATR1.42946037
34WNK41.37470376
35NEK21.36984433
36BCR1.32523491
37FRK1.31503112
38DYRK21.29903528
39BCKDK1.10576981
40AURKB1.09045984
41GRK11.09018735
42PDK21.04105038
43MAP3K41.02922927
44CDK81.02600296
45MUSK1.02309818
46ACVR1B0.98048387
47CASK0.93787880
48TGFBR10.93449625
49MAP2K70.91770262
50AURKA0.90729424
51EIF2AK20.88415244
52MAPK130.88309073
53INSRR0.86908184
54ATM0.86592906
55CSNK1G10.85591221
56CLK10.85381617
57PINK10.85210883
58CSNK1G30.82897228
59CHEK10.82556561
60PIM20.80290544
61BRSK10.80164178
62PASK0.76003570
63CCNB10.74161161
64STK30.72562837
65RPS6KA50.68997790
66CSNK1G20.68816736
67CSNK2A20.64072619
68CSNK1A1L0.63964715
69PRKCG0.62340285
70CSNK2A10.60778209
71CDK70.58867809
72DYRK30.57301364
73PRKCI0.56656004
74CSNK1E0.55223776
75ALK0.53370631
76CDK10.52634600
77MAP3K90.49184492
78LATS10.48974596
79SIK20.47562345
80NME20.47170978
81MINK10.45938738
82PLK20.45172862
83STK390.44949629
84CDK30.44143532
85CDK20.44004080
86PIM10.43375152
87OXSR10.42868376
88STK40.40557241
89ADRBK10.40448753
90PRKDC0.36543128
91CSNK1A10.35476513
92STK38L0.33340659
93ERBB30.32674224
94TAOK30.30807148
95MAPKAPK50.30764117
96PIK3CA0.27851739
97RPS6KA40.27388285
98PKN10.27274746
99ERBB40.26186387
100RAF10.25892321

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.20792383
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16954793
3RNA polymerase_Homo sapiens_hsa030203.12874150
4Proteasome_Homo sapiens_hsa030503.02739404
5Mismatch repair_Homo sapiens_hsa034302.86840410
6Homologous recombination_Homo sapiens_hsa034402.66515911
7Ribosome_Homo sapiens_hsa030102.65551882
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59605826
9Oxidative phosphorylation_Homo sapiens_hsa001902.57450364
10One carbon pool by folate_Homo sapiens_hsa006702.46457602
11Fanconi anemia pathway_Homo sapiens_hsa034602.37877215
12Protein export_Homo sapiens_hsa030602.31798890
13Parkinsons disease_Homo sapiens_hsa050122.28602069
14Base excision repair_Homo sapiens_hsa034102.28524719
15Basal transcription factors_Homo sapiens_hsa030222.25195372
16Spliceosome_Homo sapiens_hsa030402.20512901
17RNA transport_Homo sapiens_hsa030132.18753708
18Nucleotide excision repair_Homo sapiens_hsa034202.01067433
19Non-homologous end-joining_Homo sapiens_hsa034502.00587276
20RNA degradation_Homo sapiens_hsa030181.96516342
21Pyrimidine metabolism_Homo sapiens_hsa002401.90642469
22Selenocompound metabolism_Homo sapiens_hsa004501.82961417
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80041970
24Huntingtons disease_Homo sapiens_hsa050161.67026646
25Cell cycle_Homo sapiens_hsa041101.66678066
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59230495
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54105520
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.48336689
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42324878
30Purine metabolism_Homo sapiens_hsa002301.41215537
31Propanoate metabolism_Homo sapiens_hsa006401.39622499
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38578822
33Phototransduction_Homo sapiens_hsa047441.35816357
34Sulfur relay system_Homo sapiens_hsa041221.32438924
35Alzheimers disease_Homo sapiens_hsa050101.31199665
36Steroid biosynthesis_Homo sapiens_hsa001001.29904449
37Vitamin B6 metabolism_Homo sapiens_hsa007501.26674946
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22913188
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19311992
40Pyruvate metabolism_Homo sapiens_hsa006201.14996145
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12518729
42Fatty acid elongation_Homo sapiens_hsa000621.04919084
43Butanoate metabolism_Homo sapiens_hsa006501.04705734
44mRNA surveillance pathway_Homo sapiens_hsa030151.03262851
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00465753
46Folate biosynthesis_Homo sapiens_hsa007900.98699087
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98142966
48p53 signaling pathway_Homo sapiens_hsa041150.95826246
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91713933
50Nitrogen metabolism_Homo sapiens_hsa009100.90382460
51Biosynthesis of amino acids_Homo sapiens_hsa012300.80554078
52Cardiac muscle contraction_Homo sapiens_hsa042600.78210483
53Metabolic pathways_Homo sapiens_hsa011000.76828655
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76739338
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68888430
56Oocyte meiosis_Homo sapiens_hsa041140.68408821
57Carbon metabolism_Homo sapiens_hsa012000.65681623
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65219808
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64002227
60Sulfur metabolism_Homo sapiens_hsa009200.63204994
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61775368
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60176218
63Linoleic acid metabolism_Homo sapiens_hsa005910.60135042
64Tryptophan metabolism_Homo sapiens_hsa003800.59432560
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58754628
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.58115713
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57286370
68Peroxisome_Homo sapiens_hsa041460.56894842
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56070246
70Nicotine addiction_Homo sapiens_hsa050330.54724793
71beta-Alanine metabolism_Homo sapiens_hsa004100.54671812
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52311143
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50641616
74Arginine and proline metabolism_Homo sapiens_hsa003300.49911246
75N-Glycan biosynthesis_Homo sapiens_hsa005100.45482150
76Fatty acid metabolism_Homo sapiens_hsa012120.44535125
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42250587
78Glutathione metabolism_Homo sapiens_hsa004800.42165497
79Ether lipid metabolism_Homo sapiens_hsa005650.42080575
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40533209
81Regulation of autophagy_Homo sapiens_hsa041400.37450330
82Caffeine metabolism_Homo sapiens_hsa002320.36007676
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35530487
84Vitamin digestion and absorption_Homo sapiens_hsa049770.35469889
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35372748
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.34747897
87Taste transduction_Homo sapiens_hsa047420.31330572
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30476674
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29229363
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27931802
91Lysine degradation_Homo sapiens_hsa003100.27631298
92Epstein-Barr virus infection_Homo sapiens_hsa051690.23142103
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.23002123
94Olfactory transduction_Homo sapiens_hsa047400.20411731
95Collecting duct acid secretion_Homo sapiens_hsa049660.20274174
96Hippo signaling pathway_Homo sapiens_hsa043900.18531330
97TGF-beta signaling pathway_Homo sapiens_hsa043500.18290073
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17871765
99Alcoholism_Homo sapiens_hsa050340.17375113
100Hedgehog signaling pathway_Homo sapiens_hsa043400.15586935

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