ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	coronary vasculature morphogenesis (GO:0060977)	5.09235651
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.35057997
3	response to pheromone (GO:0019236)	4.33955219
4	sperm motility (GO:0030317)	3.72735593
5	exogenous drug catabolic process (GO:0042738)	3.67838278
6	neurotransmitter-gated ion channel clustering (GO:0072578)	3.65390827
7	acrosome reaction (GO:0007340)	3.53128503
8	cardiac right ventricle morphogenesis (GO:0003215)	3.52271014
9	microtubule depolymerization (GO:0007019)	3.50571402
10	nucleobase catabolic process (GO:0046113)	3.43765683
11	spermatid nucleus differentiation (GO:0007289)	3.41571412
12	Notch signaling involved in heart development (GO:0061314)	3.40595601
13	amino-acid betaine metabolic process (GO:0006577)	3.39234957
14	drug catabolic process (GO:0042737)	3.22179025
15	chromosome condensation (GO:0030261)	3.18101712
16	histone H3-K9 demethylation (GO:0033169)	3.08513362
17	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.03902890
18	positive regulation of male gonad development (GO:2000020)	3.02258337
19	axonal fasciculation (GO:0007413)	3.01228204
20	DNA packaging (GO:0006323)	3.00080081
21	regulation of axon guidance (GO:1902667)	2.98342111
22	carnitine metabolic process (GO:0009437)	2.94669690
23	retinal rod cell development (GO:0046548)	2.94160518
24	microtubule severing (GO:0051013)	2.93664111
25	fusion of sperm to egg plasma membrane (GO:0007342)	2.93374573
26	protein localization to synapse (GO:0035418)	2.87437946
27	negative regulation of fibrinolysis (GO:0051918)	2.84686428
28	regulation of axon extension involved in axon guidance (GO:0048841)	2.83702455
29	sexual reproduction (GO:0019953)	2.83416764
30	central nervous system projection neuron axonogenesis (GO:0021952)	2.82773559
31	heart valve formation (GO:0003188)	2.79272819
32	regulation of protein activation cascade (GO:2000257)	2.78127277
33	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.77719208
34	cellular ketone body metabolic process (GO:0046950)	2.76983006
35	protein-DNA complex disassembly (GO:0032986)	2.76904251
36	nucleosome disassembly (GO:0006337)	2.76904251
37	fibroblast migration (GO:0010761)	2.76575292
38	sperm capacitation (GO:0048240)	2.69042788
39	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.67748091
40	protein polyglutamylation (GO:0018095)	2.66541744
41	microtubule polymerization or depolymerization (GO:0031109)	2.65357011
42	regulation of complement activation (GO:0030449)	2.62142428
43	negative regulation of axon guidance (GO:1902668)	2.61627221
44	regulation of fibrinolysis (GO:0051917)	2.58651624
45	limb bud formation (GO:0060174)	2.58636352
46	C4-dicarboxylate transport (GO:0015740)	2.57923552
47	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.56018928
48	peptidyl-lysine dimethylation (GO:0018027)	2.51748974
49	resolution of meiotic recombination intermediates (GO:0000712)	2.48463926
50	presynaptic membrane assembly (GO:0097105)	2.48286857
51	axon extension involved in axon guidance (GO:0048846)	2.47604354
52	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.47604354
53	neuron recognition (GO:0008038)	2.46426761
54	spinal cord development (GO:0021510)	2.45838725
55	serine family amino acid catabolic process (GO:0009071)	2.44312927
56	negative regulation of Rho protein signal transduction (GO:0035024)	2.43236316
57	central nervous system neuron axonogenesis (GO:0021955)	2.43190258
58	indole-containing compound catabolic process (GO:0042436)	2.42602875
59	indolalkylamine catabolic process (GO:0046218)	2.42602875
60	tryptophan catabolic process (GO:0006569)	2.42602875
61	pre-miRNA processing (GO:0031054)	2.40277292
62	single strand break repair (GO:0000012)	2.39848861
63	ketone body metabolic process (GO:1902224)	2.37528052
64	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.36490023
65	aromatic amino acid family catabolic process (GO:0009074)	2.35720160
66	presynaptic membrane organization (GO:0097090)	2.35308149
67	intestinal cholesterol absorption (GO:0030299)	2.33034460
68	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.32203354
69	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.31709714
70	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.31689880
71	mitotic sister chromatid cohesion (GO:0007064)	2.30686184
72	cilium or flagellum-dependent cell motility (GO:0001539)	2.30023385
73	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.29068930
74	embryonic foregut morphogenesis (GO:0048617)	2.28017861
75	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.27977105
76	L-phenylalanine catabolic process (GO:0006559)	2.27977105
77	omega-hydroxylase P450 pathway (GO:0097267)	2.27566013
78	cranial nerve morphogenesis (GO:0021602)	2.27451396
79	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.25593886
80	regulation of male gonad development (GO:2000018)	2.25573266
81	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.23655243
82	regulation of neuron migration (GO:2001222)	2.21812782
83	glomerulus development (GO:0032835)	2.21435071
84	spermatid development (GO:0007286)	2.20976075
85	phosphatidylethanolamine metabolic process (GO:0046337)	2.19775808
86	establishment of nucleus localization (GO:0040023)	2.17815499
87	positive regulation of dendrite morphogenesis (GO:0050775)	2.16018559
88	atrial septum morphogenesis (GO:0060413)	2.15286136
89	cochlea development (GO:0090102)	2.14689731
90	epoxygenase P450 pathway (GO:0019373)	2.12960540
91	postsynaptic membrane organization (GO:0001941)	2.11567754
92	urea metabolic process (GO:0019627)	2.10748064
93	complement activation, alternative pathway (GO:0006957)	2.10664220
94	labyrinthine layer development (GO:0060711)	2.10533536
95	alpha-linolenic acid metabolic process (GO:0036109)	2.09970988
96	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.09570631
97	establishment of mitochondrion localization (GO:0051654)	2.08598609
98	neuronal ion channel clustering (GO:0045161)	2.07957128
99	glyoxylate metabolic process (GO:0046487)	2.07955009
100	bile acid biosynthetic process (GO:0006699)	2.07066776

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.07233990
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.33042546
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.09676745
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.85985168
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.64488487
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.63895770
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63719297
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.08155876
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07337823
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.05895783
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95689149
12	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.87055899
13	DROSHA_22980978_ChIP-Seq_HELA_Human	1.76567899
14	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.74761493
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70322669
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69342447
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.68601604
18	AHR_22903824_ChIP-Seq_MCF-7_Human	1.67585403
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.67326057
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62888709
21	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.58513533
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56447903
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.56447903
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54785707
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54785707
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54508571
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.53450504
28	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.53237331
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52281876
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51158596
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.44946201
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44281907
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42310313
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40512598
35	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.40506378
36	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.40468696
37	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.40468696
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40458996
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39741314
40	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.39650476
41	* TCF4_18268006_ChIP-ChIP_LS174T_Human	1.38681142
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38461817
43	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.35388009
44	FUS_26573619_Chip-Seq_HEK293_Human	1.34878882
45	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.34844297
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33680337
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30460877
48	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.30379292
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30135758
50	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.29904451
51	STAT3_23295773_ChIP-Seq_U87_Human	1.29888131
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28934329
53	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28891342
54	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.28556690
55	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.28502375
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27933869
57	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27410531
58	P300_19829295_ChIP-Seq_ESCs_Human	1.26119621
59	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25526057
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25498925
61	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25357342
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24302329
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24265735
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23616909
65	TP53_18474530_ChIP-ChIP_U2OS_Human	1.23259095
66	AR_25329375_ChIP-Seq_VCAP_Human	1.21589715
67	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.21553171
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21552129
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20079782
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19752966
71	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.18177027
72	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17122909
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17100691
74	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.17082768
75	AR_19668381_ChIP-Seq_PC3_Human	1.15805612
76	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.14349659
77	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.13154424
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.13002008
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.11535864
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11342589
81	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.11204273
82	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.10088079
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09632201
84	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08862977
85	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.08359781
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06665038
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06318841
88	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05821535
89	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04806872
90	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04190117
91	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.03761153
92	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01691668
93	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.01631248
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.99977233
95	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.99106928
96	TCF4_23295773_ChIP-Seq_U87_Human	0.98972335
97	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.98950939
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.98776399
99	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.98463838
100	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.97781964

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	6.22750207
2	MP0005410_abnormal_fertilization	2.46255002
3	MP0004859_abnormal_synaptic_plasticity	2.21493959
4	MP0009697_abnormal_copulation	2.12812583
5	MP0000778_abnormal_nervous_system	2.10725084
6	MP0005365_abnormal_bile_salt	2.03339733
7	MP0009384_cardiac_valve_regurgitation	2.02553966
8	MP0004270_analgesia	1.93566107
9	MP0002638_abnormal_pupillary_reflex	1.90067945
10	MP0005085_abnormal_gallbladder_physiolo	1.89663630
11	MP0003123_paternal_imprinting	1.88545626
12	MP0005377_hearing/vestibular/ear_phenot	1.88453590
13	MP0003878_abnormal_ear_physiology	1.88453590
14	MP0002139_abnormal_hepatobiliary_system	1.81324421
15	MP0005367_renal/urinary_system_phenotyp	1.78760585
16	MP0000516_abnormal_urinary_system	1.78760585
17	MP0000537_abnormal_urethra_morphology	1.78576777
18	MP0000569_abnormal_digit_pigmentation	1.61431419
19	MP0005423_abnormal_somatic_nervous	1.58826261
20	MP0002735_abnormal_chemical_nociception	1.58248766
21	MP0005670_abnormal_white_adipose	1.45976479
22	MP0000955_abnormal_spinal_cord	1.43623291
23	MP0006276_abnormal_autonomic_nervous	1.43341613
24	MP0000566_synostosis	1.42601355
25	MP0003121_genomic_imprinting	1.41792850
26	MP0001984_abnormal_olfaction	1.41411825
27	MP0003942_abnormal_urinary_system	1.41132553
28	MP0003698_abnormal_male_reproductive	1.40742298
29	MP0005187_abnormal_penis_morphology	1.40683402
30	MP0006292_abnormal_olfactory_placode	1.40623699
31	MP0000534_abnormal_ureter_morphology	1.35793500
32	MP0005248_abnormal_Harderian_gland	1.35329250
33	MP0002249_abnormal_larynx_morphology	1.34562590
34	MP0004858_abnormal_nervous_system	1.32902193
35	MP0002184_abnormal_innervation	1.32851037
36	MP0002751_abnormal_autonomic_nervous	1.31707186
37	MP0003122_maternal_imprinting	1.28426549
38	MP0003252_abnormal_bile_duct	1.24380809
39	MP0001666_abnormal_nutrient_absorption	1.22330935
40	MP0001529_abnormal_vocalization	1.20189647
41	MP0003890_abnormal_embryonic-extraembry	1.19112294
42	MP0002697_abnormal_eye_size	1.16474353
43	MP0002557_abnormal_social/conspecific_i	1.16265470
44	MP0001929_abnormal_gametogenesis	1.13784553
45	MP0003136_yellow_coat_color	1.12752504
46	MP0005394_taste/olfaction_phenotype	1.11148785
47	MP0005499_abnormal_olfactory_system	1.11148785
48	MP0002127_abnormal_cardiovascular_syste	1.10113789
49	MP0001486_abnormal_startle_reflex	1.09881389
50	MP0004811_abnormal_neuron_physiology	1.09813920
51	MP0001286_abnormal_eye_development	1.09317331
52	MP0010329_abnormal_lipoprotein_level	1.08864138
53	MP0003868_abnormal_feces_composition	1.08407435
54	MP0003115_abnormal_respiratory_system	1.06620297
55	MP0003861_abnormal_nervous_system	1.05382954
56	MP0003119_abnormal_digestive_system	1.02749058
57	MP0002882_abnormal_neuron_morphology	1.02612571
58	MP0003632_abnormal_nervous_system	1.02543237
59	MP0008875_abnormal_xenobiotic_pharmacok	1.01388066
60	MP0003315_abnormal_perineum_morphology	1.01187731
61	MP0003635_abnormal_synaptic_transmissio	0.96617701
62	MP0002063_abnormal_learning/memory/cond	0.96235990
63	MP0005253_abnormal_eye_physiology	0.96102171
64	MP0003880_abnormal_central_pattern	0.95743710
65	MP0002282_abnormal_trachea_morphology	0.94280049
66	MP0003935_abnormal_craniofacial_develop	0.94206300
67	MP0002067_abnormal_sensory_capabilities	0.93482432
68	MP0002233_abnormal_nose_morphology	0.92599422
69	MP0003567_abnormal_fetal_cardiomyocyte	0.92301058
70	MP0005551_abnormal_eye_electrophysiolog	0.90652877
71	MP0002152_abnormal_brain_morphology	0.89472341
72	MP0003385_abnormal_body_wall	0.87545137
73	MP0002572_abnormal_emotion/affect_behav	0.87285062
74	MP0000049_abnormal_middle_ear	0.87036257
75	MP0005391_vision/eye_phenotype	0.87024158
76	MP0002734_abnormal_mechanical_nocicepti	0.86154093
77	MP0003937_abnormal_limbs/digits/tail_de	0.85415429
78	MP0002752_abnormal_somatic_nervous	0.84887510
79	MP0002971_abnormal_brown_adipose	0.84005901
80	MP0002161_abnormal_fertility/fecundity	0.83969814
81	MP0003755_abnormal_palate_morphology	0.82538544
82	MP0004924_abnormal_behavior	0.81754970
83	MP0005386_behavior/neurological_phenoty	0.81754970
84	MP0004742_abnormal_vestibular_system	0.80067639
85	MP0003329_amyloid_beta_deposits	0.79359927
86	MP0009053_abnormal_anal_canal	0.79193927
87	MP0000026_abnormal_inner_ear	0.77602339
88	MP0008569_lethality_at_weaning	0.77456263
89	MP0002081_perinatal_lethality	0.76556882
90	MP0001348_abnormal_lacrimal_gland	0.76223082
91	MP0003943_abnormal_hepatobiliary_system	0.76007097
92	MP0009672_abnormal_birth_weight	0.75742143
93	MP0005076_abnormal_cell_differentiation	0.75642228
94	MP0002092_abnormal_eye_morphology	0.75212138
95	MP0003091_abnormal_cell_migration	0.74083392
96	MP0000639_abnormal_adrenal_gland	0.73748689
97	MP0005379_endocrine/exocrine_gland_phen	0.73245105
98	MP0002064_seizures	0.72872877
99	MP0001293_anophthalmia	0.71818809
100	MP0001661_extended_life_span	0.70982611

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	3.79313647
2	Genetic anticipation (HP:0003743)	3.46105067
3	Cortical dysplasia (HP:0002539)	3.05716837
4	Prolonged partial thromboplastin time (HP:0003645)	2.99350118
5	Renovascular hypertension (HP:0100817)	2.98163800
6	Bronchomalacia (HP:0002780)	2.82172767
7	Pheochromocytoma (HP:0002666)	2.63288728
8	Papillary thyroid carcinoma (HP:0002895)	2.54189874
9	Abnormality of the ischium (HP:0003174)	2.52161190
10	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.52046194
11	Conjugated hyperbilirubinemia (HP:0002908)	2.46928354
12	Vertebral arch anomaly (HP:0008438)	2.45089191
13	Complement deficiency (HP:0004431)	2.44595921
14	Exotropia (HP:0000577)	2.38326648
15	Progressive cerebellar ataxia (HP:0002073)	2.36855853
16	Neonatal short-limb short stature (HP:0008921)	2.35925761
17	Morphological abnormality of the middle ear (HP:0008609)	2.32223478
18	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.26179438
19	Scanning speech (HP:0002168)	2.25669549
20	Hyperacusis (HP:0010780)	2.24389735
21	Turricephaly (HP:0000262)	2.18618749
22	Cutaneous finger syndactyly (HP:0010554)	2.14503682
23	Hypobetalipoproteinemia (HP:0003563)	2.10161358
24	Hypoplasia of the brainstem (HP:0002365)	2.09467854
25	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.09467854
26	High anterior hairline (HP:0009890)	2.08552794
27	Abnormality of the parathyroid morphology (HP:0011766)	2.08525291
28	Midline defect of the nose (HP:0004122)	2.07578745
29	Chorioretinal atrophy (HP:0000533)	2.06997772
30	Hypoplastic ischia (HP:0003175)	2.06406378
31	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.02887155
32	Hypoalphalipoproteinemia (HP:0003233)	2.02702313
33	Obsessive-compulsive behavior (HP:0000722)	2.02199171
34	Amblyopia (HP:0000646)	2.01427245
35	Neuroendocrine neoplasm (HP:0100634)	1.99541772
36	Bifid scrotum (HP:0000048)	1.97538874
37	Sex reversal (HP:0012245)	1.94347703
38	Abnormal sex determination (HP:0012244)	1.94347703
39	Hypercholesterolemia (HP:0003124)	1.92855693
40	Bell-shaped thorax (HP:0001591)	1.92275712
41	Abnormality of the diencephalon (HP:0010662)	1.92062646
42	Tubulointerstitial nephritis (HP:0001970)	1.91444579
43	Cutaneous syndactyly (HP:0012725)	1.91260738
44	Overriding aorta (HP:0002623)	1.90883452
45	Hypolipoproteinemia (HP:0010981)	1.88299138
46	Retinal dysplasia (HP:0007973)	1.83556908
47	Hammertoe (HP:0001765)	1.80713245
48	Intellectual disability, moderate (HP:0002342)	1.78692963
49	Renal hypoplasia (HP:0000089)	1.78622294
50	Trigonocephaly (HP:0000243)	1.77434307
51	Insomnia (HP:0100785)	1.77366919
52	Insidious onset (HP:0003587)	1.76812461
53	Termporal pattern (HP:0011008)	1.76812461
54	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.73843380
55	Renal duplication (HP:0000075)	1.73772124
56	Elfin facies (HP:0004428)	1.73628055
57	Chronic hepatic failure (HP:0100626)	1.73208825
58	Abnormality of the aortic arch (HP:0012303)	1.73117574
59	Abnormality of complement system (HP:0005339)	1.70941049
60	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.69861900
61	Increased nuchal translucency (HP:0010880)	1.69467794
62	Abnormality of the lower motor neuron (HP:0002366)	1.68944759
63	Esophageal atresia (HP:0002032)	1.68300643
64	Hepatoblastoma (HP:0002884)	1.67337985
65	Hemorrhage of the eye (HP:0011885)	1.66890888
66	Preauricular pit (HP:0004467)	1.66589775
67	Periauricular skin pits (HP:0100277)	1.66589775
68	Anophthalmia (HP:0000528)	1.65909370
69	Intestinal atresia (HP:0011100)	1.64822668
70	Truncal obesity (HP:0001956)	1.64792455
71	Vaginal atresia (HP:0000148)	1.62024603
72	Bicornuate uterus (HP:0000813)	1.60189582
73	Bifid tongue (HP:0010297)	1.60036570
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.59048713
75	Urinary urgency (HP:0000012)	1.58579811
76	Leiomyosarcoma (HP:0100243)	1.58037450
77	Uterine leiomyosarcoma (HP:0002891)	1.58037450
78	Heterotopia (HP:0002282)	1.57968524
79	Specific learning disability (HP:0001328)	1.57352919
80	Polyphagia (HP:0002591)	1.56017722
81	Genital tract atresia (HP:0001827)	1.55935193
82	Drooling (HP:0002307)	1.54954091
83	Thyroid carcinoma (HP:0002890)	1.53465309
84	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.52744658
85	Omphalocele (HP:0001539)	1.52322767
86	Optic nerve hypoplasia (HP:0000609)	1.51237061
87	Vitreoretinal degeneration (HP:0000655)	1.50988052
88	Impaired vibration sensation in the lower limbs (HP:0002166)	1.49242599
89	Anal stenosis (HP:0002025)	1.49147970
90	Wide anterior fontanel (HP:0000260)	1.49097990
91	Megalocornea (HP:0000485)	1.49092118
92	Ulnar bowing (HP:0003031)	1.49029513
93	Aplasia involving bones of the extremities (HP:0009825)	1.48048601
94	Aplasia involving bones of the upper limbs (HP:0009823)	1.48048601
95	Aplasia of the phalanges of the hand (HP:0009802)	1.48048601
96	Blue irides (HP:0000635)	1.48003569
97	Transitional cell carcinoma of the bladder (HP:0006740)	1.47946561
98	Abnormality of the pubic bones (HP:0003172)	1.47813554
99	Malignant gastrointestinal tract tumors (HP:0006749)	1.47757479
100	Gastrointestinal carcinoma (HP:0002672)	1.47757479

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BRD4	3.20431189
2	CASK	3.00996165
3	MARK1	2.96483602
4	NTRK2	2.96107033
5	BCR	2.57774018
6	PKN2	2.41883880
7	TNIK	2.12843128
8	CDK12	1.98859352
9	EPHA4	1.96244790
10	LATS1	1.88784911
11	CAMK1G	1.88702535
12	MKNK2	1.87059505
13	FGFR2	1.68546592
14	MAP4K2	1.68403010
15	PLK4	1.66510447
16	EEF2K	1.66080093
17	MST1R	1.65022020
18	STK39	1.60349339
19	DYRK3	1.59938720
20	LATS2	1.58300725
21	RIPK1	1.58227559
22	DDR2	1.56380780
23	TRIB3	1.50853469
24	PNCK	1.47382741
25	CAMK1D	1.46487451
26	MAP2K7	1.43229288
27	MET	1.35628970
28	NTRK1	1.35207984
29	MAP3K4	1.33825126
30	RET	1.27517116
31	TYRO3	1.25012526
32	CDC7	1.22844903
33	FGFR4	1.20840819
34	FGFR1	1.14138005
35	PDGFRA	1.12440827
36	ICK	1.11566087
37	SIK2	1.11519157
38	SCYL2	1.08646568
39	DYRK1B	1.08216758
40	MKNK1	1.05650439
41	MTOR	1.05629429
42	NTRK3	1.03700848
43	LMTK2	1.03403430
44	WNK1	1.02667691
45	EPHA2	0.99474797
46	RPS6KA4	0.98868675
47	ERBB2	0.98498433
48	PRKAA1	0.90829345
49	WNK4	0.88901593
50	INSRR	0.87433390
51	MAPK15	0.87246075
52	TESK1	0.86940932
53	ERBB3	0.86689470
54	EPHB1	0.84424521
55	MAP3K6	0.82221935
56	EPHA3	0.81791669
57	MAP3K7	0.81657182
58	CSNK1G2	0.80739638
59	KSR1	0.79971046
60	UHMK1	0.78044970
61	CSNK1A1L	0.76969768
62	MINK1	0.75272289
63	FGFR3	0.70133258
64	YES1	0.69347115
65	NEK2	0.66552168
66	DYRK2	0.66057890
67	PRKAA2	0.65679595
68	CSNK1G3	0.65171307
69	FER	0.65106970
70	CDK7	0.64244578
71	PRKD3	0.62907295
72	BMPR1B	0.62685177
73	FRK	0.61208801
74	CAMK4	0.59239646
75	PRKCE	0.58522595
76	STK38	0.57391863
77	CDK1	0.56952834
78	CSNK1G1	0.55722807
79	CDK3	0.54599614
80	CDK5	0.53290422
81	PRKACB	0.53018921
82	GSK3B	0.52548119
83	MAP3K10	0.50401037
84	PRKCG	0.49941955
85	CSNK1D	0.49399863
86	CSNK1E	0.48104855
87	AKT3	0.47982201
88	STK38L	0.47782824
89	OXSR1	0.47298225
90	STK11	0.47221996
91	MAPK10	0.47161395
92	MAPK8	0.46821171
93	PRKCZ	0.45115453
94	MAPK13	0.44478059
95	CDK2	0.43486670
96	NEK6	0.42915996
97	RPS6KA2	0.42113062
98	EPHB2	0.42092077
99	SGK494	0.41720872
100	SGK223	0.41720872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.78660541
2	Butanoate metabolism_Homo sapiens_hsa00650	2.73856461
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.56236258
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.25546070
5	Lysine degradation_Homo sapiens_hsa00310	2.20480669
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.18104858
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.14832115
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.01528595
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.98696037
10	Caffeine metabolism_Homo sapiens_hsa00232	1.97437578
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.74139546
12	Retinol metabolism_Homo sapiens_hsa00830	1.68707479
13	Phenylalanine metabolism_Homo sapiens_hsa00360	1.65702625
14	PPAR signaling pathway_Homo sapiens_hsa03320	1.53082590
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.45466978
16	Bile secretion_Homo sapiens_hsa04976	1.45377733
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.44833005
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.41553864
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.40735379
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36330790
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.28150552
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.27471573
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.23152644
24	Adherens junction_Homo sapiens_hsa04520	1.22666004
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.21801580
26	Axon guidance_Homo sapiens_hsa04360	1.21527463
27	Fatty acid degradation_Homo sapiens_hsa00071	1.20335798
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16234348
29	Nicotine addiction_Homo sapiens_hsa05033	1.15073536
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13149271
31	Basal cell carcinoma_Homo sapiens_hsa05217	1.13030857
32	Propanoate metabolism_Homo sapiens_hsa00640	1.11009281
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07014075
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06836332
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.05622214
36	ABC transporters_Homo sapiens_hsa02010	1.05144048
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.03456672
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.03039608
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.02666919
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01250426
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.99277910
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.98775605
43	Circadian entrainment_Homo sapiens_hsa04713	0.92568256
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91104662
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.90820826
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.90678415
47	Tight junction_Homo sapiens_hsa04530	0.90223657
48	GABAergic synapse_Homo sapiens_hsa04727	0.88563433
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88403733
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.85196540
51	Olfactory transduction_Homo sapiens_hsa04740	0.84247828
52	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.83506518
53	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.83165822
54	Gap junction_Homo sapiens_hsa04540	0.83088125
55	Wnt signaling pathway_Homo sapiens_hsa04310	0.81419028
56	Histidine metabolism_Homo sapiens_hsa00340	0.80460869
57	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.79360707
58	Alcoholism_Homo sapiens_hsa05034	0.76428941
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.76068328
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.75873311
61	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.75614948
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75497688
63	Taste transduction_Homo sapiens_hsa04742	0.73764885
64	Type II diabetes mellitus_Homo sapiens_hsa04930	0.71996676
65	AMPK signaling pathway_Homo sapiens_hsa04152	0.69482096
66	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68868095
67	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64443057
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.63390034
69	Morphine addiction_Homo sapiens_hsa05032	0.62847355
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62380426
71	Cholinergic synapse_Homo sapiens_hsa04725	0.60034113
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.59495830
73	Melanogenesis_Homo sapiens_hsa04916	0.58875717
74	Estrogen signaling pathway_Homo sapiens_hsa04915	0.57303588
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56903871
76	Endometrial cancer_Homo sapiens_hsa05213	0.56157352
77	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.53846265
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.53374632
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52203496
80	Thyroid cancer_Homo sapiens_hsa05216	0.51905146
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.51426460
82	MicroRNAs in cancer_Homo sapiens_hsa05206	0.50796718
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.50646923
84	Cocaine addiction_Homo sapiens_hsa05030	0.49109279
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48033279
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47072885
87	Prion diseases_Homo sapiens_hsa05020	0.46443813
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46418519
89	Peroxisome_Homo sapiens_hsa04146	0.45063113
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44907173
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43771951
92	Serotonergic synapse_Homo sapiens_hsa04726	0.43325095
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42831506
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.42370465
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40021193
96	Prolactin signaling pathway_Homo sapiens_hsa04917	0.39673732
97	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.39288660
98	Phototransduction_Homo sapiens_hsa04744	0.38970425
99	Notch signaling pathway_Homo sapiens_hsa04330	0.36694747
100	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36019278

C1ORF111

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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