C1ORF112

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.23539171
2CENP-A containing nucleosome assembly (GO:0034080)5.23320688
3DNA strand elongation involved in DNA replication (GO:0006271)5.13099267
4mitotic sister chromatid segregation (GO:0000070)5.03424459
5protein localization to kinetochore (GO:0034501)4.95149463
6DNA strand elongation (GO:0022616)4.90514555
7telomere maintenance via semi-conservative replication (GO:0032201)4.80028446
8sister chromatid segregation (GO:0000819)4.78201380
9mitotic metaphase plate congression (GO:0007080)4.75981830
10nuclear pore complex assembly (GO:0051292)4.74331263
11DNA replication checkpoint (GO:0000076)4.73054881
12histone exchange (GO:0043486)4.49674922
13protein localization to chromosome, centromeric region (GO:0071459)4.42000788
14metaphase plate congression (GO:0051310)4.38471863
15nuclear pore organization (GO:0006999)4.37921844
16telomere maintenance via recombination (GO:0000722)4.32265969
17mitotic recombination (GO:0006312)4.27859472
18mitotic chromosome condensation (GO:0007076)4.17554120
19spindle checkpoint (GO:0031577)4.17403870
20synapsis (GO:0007129)4.13579854
21kinetochore organization (GO:0051383)4.12959818
22proteasome assembly (GO:0043248)4.12413989
23mitotic sister chromatid cohesion (GO:0007064)4.11901992
24DNA replication-independent nucleosome organization (GO:0034724)4.10208890
25DNA replication-independent nucleosome assembly (GO:0006336)4.10208890
26DNA double-strand break processing (GO:0000729)4.06782241
27DNA unwinding involved in DNA replication (GO:0006268)4.05102263
28mitotic spindle checkpoint (GO:0071174)4.04054553
29establishment of integrated proviral latency (GO:0075713)4.02835191
30DNA replication initiation (GO:0006270)4.02828230
31mitotic nuclear envelope disassembly (GO:0007077)4.02775444
32negative regulation of chromosome segregation (GO:0051985)4.02648298
33negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.00592338
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.00592338
35negative regulation of mitotic sister chromatid segregation (GO:0033048)4.00592338
36negative regulation of mitotic sister chromatid separation (GO:2000816)4.00592338
37negative regulation of sister chromatid segregation (GO:0033046)4.00592338
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.90830235
39mitotic spindle assembly checkpoint (GO:0007094)3.83627045
40regulation of centriole replication (GO:0046599)3.82659703
41regulation of chromosome segregation (GO:0051983)3.81812551
42spindle assembly checkpoint (GO:0071173)3.80055327
43DNA replication-dependent nucleosome assembly (GO:0006335)3.79746213
44DNA replication-dependent nucleosome organization (GO:0034723)3.79746213
45regulation of mitotic spindle checkpoint (GO:1903504)3.78172407
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78172407
47regulation of mitotic metaphase/anaphase transition (GO:0030071)3.75340440
48regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75340440
49establishment of chromosome localization (GO:0051303)3.74100989
50purine nucleobase biosynthetic process (GO:0009113)3.73526049
51double-strand break repair via nonhomologous end joining (GO:0006303)3.73362006
52non-recombinational repair (GO:0000726)3.73362006
53replication fork processing (GO:0031297)3.71077472
54nuclear envelope disassembly (GO:0051081)3.71071198
55membrane disassembly (GO:0030397)3.71071198
56regulation of mitotic sister chromatid separation (GO:0010965)3.70978902
57regulation of mitotic sister chromatid segregation (GO:0033047)3.70978902
58regulation of sister chromatid segregation (GO:0033045)3.70978902
59DNA ligation (GO:0006266)3.70665625
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.64869492
61attachment of spindle microtubules to kinetochore (GO:0008608)3.63417834
62meiotic chromosome segregation (GO:0045132)3.58610152
63pore complex assembly (GO:0046931)3.56723174
64nucleobase biosynthetic process (GO:0046112)3.55586405
65DNA catabolic process, exonucleolytic (GO:0000738)3.53937643
66kinetochore assembly (GO:0051382)3.53259565
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53151381
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51975539
69chromosome segregation (GO:0007059)3.51493721
70telomere maintenance via telomere lengthening (GO:0010833)3.51045909
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48831732
72IMP biosynthetic process (GO:0006188)3.44648021
73regulation of DNA endoreduplication (GO:0032875)3.40415192
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.39480379
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.34718270
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34718270
77protein K6-linked ubiquitination (GO:0085020)3.28607723
78positive regulation of chromosome segregation (GO:0051984)3.26417294
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23215501
80DNA strand renaturation (GO:0000733)3.23214812
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22467334
82DNA synthesis involved in DNA repair (GO:0000731)3.21739017
83microtubule depolymerization (GO:0007019)3.21517140
84protein localization to chromosome (GO:0034502)3.21250849
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20370806
86establishment of viral latency (GO:0019043)3.19268887
87regulation of centrosome cycle (GO:0046605)3.17048355
88negative regulation of ligase activity (GO:0051352)3.15811770
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15811770
90double-strand break repair via homologous recombination (GO:0000724)3.15647968
91recombinational repair (GO:0000725)3.15012011
92negative regulation of mitosis (GO:0045839)3.14555853
93DNA topological change (GO:0006265)3.13425425
94telomere maintenance (GO:0000723)3.12540787
95resolution of meiotic recombination intermediates (GO:0000712)3.12487451
96telomere organization (GO:0032200)3.12379209
97mitotic cell cycle (GO:0000278)3.11842280
98chromatin assembly or disassembly (GO:0006333)3.11640486
99ATP-dependent chromatin remodeling (GO:0043044)3.10389857
100regulation of helicase activity (GO:0051095)3.05933430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.64387755
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.17469871
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.07991465
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44208763
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.89835446
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.31245113
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.18387119
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.09241793
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02541612
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78071237
11AR_21909140_ChIP-Seq_LNCAP_Human2.63361076
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53453889
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52000639
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46324985
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.43366265
16* ELK1_19687146_ChIP-ChIP_HELA_Human2.41144999
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38279582
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36227301
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.34631106
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.29350947
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28467167
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12818553
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11258247
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10413850
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09153003
26* VDR_23849224_ChIP-Seq_CD4+_Human2.05858258
27FOXP3_21729870_ChIP-Seq_TREG_Human2.04531519
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04026410
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02288804
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97212851
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87961726
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87852243
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87098060
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87075950
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85221288
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82496623
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77601978
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73641569
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70953664
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69263011
41* TTF2_22483619_ChIP-Seq_HELA_Human1.68669211
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59624720
43GABP_19822575_ChIP-Seq_HepG2_Human1.56502057
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49909602
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48091926
46MYC_18940864_ChIP-ChIP_HL60_Human1.47461931
47XRN2_22483619_ChIP-Seq_HELA_Human1.44787859
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.42337085
49EWS_26573619_Chip-Seq_HEK293_Human1.39748166
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32331665
51* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31234725
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28664968
53KDM5A_27292631_Chip-Seq_BREAST_Human1.24113069
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21286657
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.21026245
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20034949
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17188810
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15731058
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15721838
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15408855
61FUS_26573619_Chip-Seq_HEK293_Human1.15148964
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.14109659
63ZNF274_21170338_ChIP-Seq_K562_Hela1.13484411
64VDR_22108803_ChIP-Seq_LS180_Human1.11011246
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.10637958
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07277798
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05256621
68IRF1_19129219_ChIP-ChIP_H3396_Human1.04694356
69YY1_21170310_ChIP-Seq_MESCs_Mouse0.99540067
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99021916
71SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95935712
72ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95306899
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94330337
74TP63_19390658_ChIP-ChIP_HaCaT_Human0.92849013
75IGF1R_20145208_ChIP-Seq_DFB_Human0.91230670
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.90449358
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90390419
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89985209
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.80960023
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79311318
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78496843
82CIITA_25753668_ChIP-Seq_RAJI_Human0.77647015
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77175889
84* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76171815
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75779308
86TFEB_21752829_ChIP-Seq_HELA_Human0.72849877
87TAF15_26573619_Chip-Seq_HEK293_Human0.69458979
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69072537
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.63928521
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.62046144
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.60411184
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.60401307
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.59726130
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.58775663
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.57598085
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.57378679
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.57086680
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.56954075
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.56319535
100P300_19829295_ChIP-Seq_ESCs_Human0.56123396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.80557582
2MP0008057_abnormal_DNA_replication5.40951221
3MP0008058_abnormal_DNA_repair4.62461686
4MP0003693_abnormal_embryo_hatching4.59801631
5MP0003111_abnormal_nucleus_morphology4.52654299
6MP0004957_abnormal_blastocyst_morpholog4.13161219
7MP0003077_abnormal_cell_cycle3.89664809
8MP0008932_abnormal_embryonic_tissue3.10459886
9MP0008877_abnormal_DNA_methylation2.93109469
10MP0009697_abnormal_copulation2.81339512
11MP0008007_abnormal_cellular_replicative2.75270416
12MP0003718_maternal_effect2.59787295
13MP0006292_abnormal_olfactory_placode2.41385661
14MP0003786_premature_aging2.18994953
15MP0003941_abnormal_skin_development2.12222783
16MP0000372_irregular_coat_pigmentation1.90933710
17MP0003890_abnormal_embryonic-extraembry1.87127283
18MP0010307_abnormal_tumor_latency1.83467099
19MP0000350_abnormal_cell_proliferation1.75657852
20MP0002938_white_spotting1.74538265
21MP0001730_embryonic_growth_arrest1.66440235
22MP0006035_abnormal_mitochondrial_morpho1.64911600
23MP0002210_abnormal_sex_determination1.59701326
24MP0001697_abnormal_embryo_size1.57673437
25MP0001929_abnormal_gametogenesis1.56784501
26MP0001293_anophthalmia1.51099559
27MP0005380_embryogenesis_phenotype1.51030878
28MP0001672_abnormal_embryogenesis/_devel1.51030878
29MP0003806_abnormal_nucleotide_metabolis1.49411847
30MP0003937_abnormal_limbs/digits/tail_de1.44241910
31MP0003136_yellow_coat_color1.38148152
32MP0002084_abnormal_developmental_patter1.34144992
33MP0002085_abnormal_embryonic_tissue1.31270279
34MP0002080_prenatal_lethality1.31188902
35MP0000313_abnormal_cell_death1.28907762
36MP0001145_abnormal_male_reproductive1.28269147
37MP0003984_embryonic_growth_retardation1.25409318
38MP0000653_abnormal_sex_gland1.23841050
39MP0002088_abnormal_embryonic_growth/wei1.22766302
40MP0010352_gastrointestinal_tract_polyps1.22760518
41MP0008789_abnormal_olfactory_epithelium1.20458540
42MP0002396_abnormal_hematopoietic_system1.18646038
43MP0000358_abnormal_cell_content/1.15673393
44MP0009672_abnormal_birth_weight1.13824898
45MP0003567_abnormal_fetal_cardiomyocyte1.10830906
46MP0004197_abnormal_fetal_growth/weight/1.09585836
47MP0001119_abnormal_female_reproductive1.09014029
48MP0004147_increased_porphyrin_level1.08932078
49MP0006054_spinal_hemorrhage1.07942123
50MP0002102_abnormal_ear_morphology1.04890352
51MP0005075_abnormal_melanosome_morpholog1.04111904
52MP0003698_abnormal_male_reproductive1.03481267
53MP0002019_abnormal_tumor_incidence1.03364752
54MP0006036_abnormal_mitochondrial_physio1.01623819
55MP0003186_abnormal_redox_activity1.00800713
56MP0001529_abnormal_vocalization1.00578688
57MP0003119_abnormal_digestive_system0.98624970
58MP0002160_abnormal_reproductive_system0.95858847
59MP0008995_early_reproductive_senescence0.95605654
60MP0001286_abnormal_eye_development0.95090958
61MP0006072_abnormal_retinal_apoptosis0.93217944
62MP0003121_genomic_imprinting0.92983921
63MP0002086_abnormal_extraembryonic_tissu0.92111382
64MP0005171_absent_coat_pigmentation0.91883337
65MP0002697_abnormal_eye_size0.87376835
66MP0005395_other_phenotype0.83915972
67MP0002111_abnormal_tail_morphology0.83597307
68MP0009703_decreased_birth_body0.82304521
69MP0005394_taste/olfaction_phenotype0.80897860
70MP0005499_abnormal_olfactory_system0.80897860
71MP0005408_hypopigmentation0.76959772
72MP0003699_abnormal_female_reproductive0.75957432
73MP0000647_abnormal_sebaceous_gland0.75702021
74MP0002161_abnormal_fertility/fecundity0.74728911
75MP0005389_reproductive_system_phenotype0.74682826
76MP0002751_abnormal_autonomic_nervous0.74137491
77MP0003950_abnormal_plasma_membrane0.73942922
78MP0010030_abnormal_orbit_morphology0.71401271
79MP0000490_abnormal_crypts_of0.68659913
80MP0003943_abnormal_hepatobiliary_system0.67588800
81MP0002233_abnormal_nose_morphology0.66950215
82MP0005410_abnormal_fertilization0.65414949
83MP0002234_abnormal_pharynx_morphology0.65408023
84MP0005384_cellular_phenotype0.63285279
85MP0001764_abnormal_homeostasis0.61785694
86MP0005174_abnormal_tail_pigmentation0.61444353
87MP0005253_abnormal_eye_physiology0.61411012
88MP0000569_abnormal_digit_pigmentation0.61047353
89MP0001919_abnormal_reproductive_system0.60497493
90MP0002095_abnormal_skin_pigmentation0.59787315
91MP0003195_calcinosis0.58648283
92MP0003787_abnormal_imprinting0.57107829
93MP0001661_extended_life_span0.56779223
94MP0001324_abnormal_eye_pigmentation0.55052503
95MP0000428_abnormal_craniofacial_morphol0.54775788
96MP0005391_vision/eye_phenotype0.54664876
97MP0004808_abnormal_hematopoietic_stem0.54318397
98MP0001346_abnormal_lacrimal_gland0.52898245
99MP0001485_abnormal_pinna_reflex0.50192206
100MP0001727_abnormal_embryo_implantation0.49449573

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.36330228
2Chromsome breakage (HP:0040012)5.89835335
3Abnormality of chromosome stability (HP:0003220)4.51488937
4Meckel diverticulum (HP:0002245)4.38806566
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.38094639
6Abnormality of the ileum (HP:0001549)4.34375720
7Abnormality of the preputium (HP:0100587)4.26538780
8Small intestinal stenosis (HP:0012848)3.72060586
9Duodenal stenosis (HP:0100867)3.72060586
10Birth length less than 3rd percentile (HP:0003561)3.60783817
11Volvulus (HP:0002580)3.47743553
12Nephroblastoma (Wilms tumor) (HP:0002667)3.35504916
13Abnormality of the labia minora (HP:0012880)3.34793982
14Abnormality of the duodenum (HP:0002246)3.20786215
15Embryonal renal neoplasm (HP:0011794)3.19970505
16Abnormal lung lobation (HP:0002101)3.17527054
17Myelodysplasia (HP:0002863)3.07201667
18Sloping forehead (HP:0000340)3.01311178
19Absent radius (HP:0003974)2.95192742
20Colon cancer (HP:0003003)2.91619011
21Ectopic kidney (HP:0000086)2.88671854
22Clubbing of toes (HP:0100760)2.82691099
23Aplasia involving forearm bones (HP:0009822)2.81565856
24Absent forearm bone (HP:0003953)2.81565856
25Abnormality of the carotid arteries (HP:0005344)2.79206396
26Increased nuchal translucency (HP:0010880)2.65502715
27Cortical dysplasia (HP:0002539)2.62337395
28Rhabdomyosarcoma (HP:0002859)2.51501254
29Duplicated collecting system (HP:0000081)2.42939892
30Medulloblastoma (HP:0002885)2.41794896
31Triphalangeal thumb (HP:0001199)2.41705463
32Microvesicular hepatic steatosis (HP:0001414)2.37162662
33Horseshoe kidney (HP:0000085)2.31134557
34Reticulocytopenia (HP:0001896)2.31059227
35Multiple enchondromatosis (HP:0005701)2.31000551
36Ependymoma (HP:0002888)2.25761532
37Agnosia (HP:0010524)2.24902334
38Abnormality of DNA repair (HP:0003254)2.20565195
39Absent thumb (HP:0009777)2.20417216
40Pancreatic islet-cell hyperplasia (HP:0004510)2.19811943
41Type I transferrin isoform profile (HP:0003642)2.16195867
42Neoplasm of the colon (HP:0100273)2.13787474
43Abnormality of the renal collecting system (HP:0004742)2.13062526
44Acute encephalopathy (HP:0006846)2.12279825
45Cafe-au-lait spot (HP:0000957)2.11034039
46Abnormality of methionine metabolism (HP:0010901)2.09765226
47Glioma (HP:0009733)2.09573324
48Short thumb (HP:0009778)2.08950295
49Hypoplasia of the pons (HP:0012110)2.07694570
50Acute necrotizing encephalopathy (HP:0006965)2.05893668
51Pancytopenia (HP:0001876)2.05167351
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03871179
53Abnormal protein N-linked glycosylation (HP:0012347)2.03871179
54Abnormal protein glycosylation (HP:0012346)2.03871179
55Abnormal glycosylation (HP:0012345)2.03871179
56Abnormality of the pons (HP:0007361)2.01131089
57Carpal bone hypoplasia (HP:0001498)1.98861594
58Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98506564
59Choanal atresia (HP:0000453)1.97593894
60Abnormality of alanine metabolism (HP:0010916)1.97239201
61Hyperalaninemia (HP:0003348)1.97239201
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97239201
63Patellar aplasia (HP:0006443)1.95936036
64Increased CSF lactate (HP:0002490)1.95390052
65Embryonal neoplasm (HP:0002898)1.91191284
66Abnormal mitochondria in muscle tissue (HP:0008316)1.89668043
67Oligodactyly (hands) (HP:0001180)1.89509376
68Intestinal atresia (HP:0011100)1.88256243
69Bone marrow hypocellularity (HP:0005528)1.85729433
70Small hand (HP:0200055)1.83826977
71Abnormality of serum amino acid levels (HP:0003112)1.81675226
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.80502019
73Arteriovenous malformation (HP:0100026)1.80203655
74Hypoplastic pelvis (HP:0008839)1.79769590
75Abnormality of glycolysis (HP:0004366)1.79089321
76Increased serum pyruvate (HP:0003542)1.78470407
77Aplasia/Hypoplasia of the patella (HP:0006498)1.75651933
78Astrocytoma (HP:0009592)1.75223304
79Abnormality of the astrocytes (HP:0100707)1.75223304
80Hypoplasia of the fovea (HP:0007750)1.74520565
81Aplasia/Hypoplasia of the fovea (HP:0008060)1.74520565
82Increased serum lactate (HP:0002151)1.71594859
83Cerebral edema (HP:0002181)1.71524268
84Ovarian neoplasm (HP:0100615)1.70557651
85Facial cleft (HP:0002006)1.68960533
86Cleft eyelid (HP:0000625)1.68786868
87Astigmatism (HP:0000483)1.67687583
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67471560
89Neoplasm of the adrenal gland (HP:0100631)1.67429686
90Increased hepatocellular lipid droplets (HP:0006565)1.64693570
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64656386
92Dandy-Walker malformation (HP:0001305)1.64484240
93Degeneration of anterior horn cells (HP:0002398)1.64282983
94Abnormality of the anterior horn cell (HP:0006802)1.64282983
95Combined immunodeficiency (HP:0005387)1.64137915
96Hepatocellular necrosis (HP:0001404)1.63539553
97Reduced antithrombin III activity (HP:0001976)1.63514719
98Mitochondrial inheritance (HP:0001427)1.62753486
99Hyperglycinemia (HP:0002154)1.62154853
100Bifid tongue (HP:0010297)1.62082734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.88801782
2CDC73.61031099
3TTK3.45477634
4PBK3.40114499
5ZAK3.20563778
6PLK43.10463817
7WEE13.08022997
8BRSK22.86594097
9SRPK12.81919142
10NEK12.67473118
11VRK22.56855227
12EIF2AK12.54011503
13EIF2AK32.50485055
14PLK32.37659169
15TSSK62.37620910
16TRIM282.28062064
17MST42.19468767
18MKNK22.18933221
19VRK12.02245053
20MKNK11.99769995
21PLK11.92719700
22NUAK11.81718222
23BRSK11.65959725
24ATR1.56360572
25TAF11.55610861
26CHEK21.52551820
27ACVR1B1.50293014
28NEK21.47709304
29AURKB1.28402586
30WNK31.26410264
31BMPR1B1.26279238
32PNCK1.22123704
33TNIK1.16606151
34CCNB11.07855023
35STK161.05978224
36FRK1.02927527
37EIF2AK21.01412859
38CHEK11.00571916
39STK100.99319201
40ATM0.96947747
41PDK20.95630146
42NME10.94465823
43STK30.94268823
44TLK10.92177206
45CDK70.91569934
46STK40.90475441
47BCR0.85765726
48SCYL20.83843417
49AURKA0.83692608
50CSNK1G10.77882435
51PLK20.76542395
52BRD40.71420103
53MELK0.67410220
54MAP3K80.64676168
55CDK10.62271345
56CSNK1G30.59139105
57LATS10.57865505
58CLK10.57183941
59NME20.56929498
60PASK0.53987183
61FGFR10.50000172
62CDK20.49852241
63CSNK1A1L0.49453252
64RPS6KB20.49004429
65CSNK2A10.48288269
66CDK80.48277409
67RPS6KA40.45361978
68CDK40.44717435
69CSNK2A20.44669051
70INSRR0.42809726
71ERBB40.42231611
72NLK0.41871693
73CSNK1G20.41057236
74SIK30.40653173
75DYRK30.40184221
76MARK30.38235152
77CDK30.37286945
78MAP3K40.36946090
79ALK0.36708841
80TGFBR10.36322187
81MUSK0.36237444
82PRKDC0.35091659
83CDK120.34130660
84FLT30.33998601
85DAPK10.32230946
86RPS6KA50.31308703
87CSNK1E0.31307994
88BCKDK0.30322764
89MAP3K100.29069752
90ERBB30.28363409
91OXSR10.28056542
92ADRBK20.25792580
93DYRK20.24588266
94PAK10.24175793
95NEK90.23963739
96CDK60.23065623
97BRAF0.22041934
98KDR0.21900599
99YES10.21788292
100PRKCI0.21038167

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85497032
2Mismatch repair_Homo sapiens_hsa034304.38439880
3Proteasome_Homo sapiens_hsa030503.70286088
4Homologous recombination_Homo sapiens_hsa034403.66538103
5Non-homologous end-joining_Homo sapiens_hsa034503.61486849
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16854972
7Fanconi anemia pathway_Homo sapiens_hsa034603.12532724
8Base excision repair_Homo sapiens_hsa034102.90196559
9Cell cycle_Homo sapiens_hsa041102.85610831
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64912081
11RNA transport_Homo sapiens_hsa030132.63316606
12Nucleotide excision repair_Homo sapiens_hsa034202.55401352
13RNA polymerase_Homo sapiens_hsa030202.46166644
14One carbon pool by folate_Homo sapiens_hsa006702.43225706
15Spliceosome_Homo sapiens_hsa030402.26678952
16RNA degradation_Homo sapiens_hsa030181.92414211
17Pyrimidine metabolism_Homo sapiens_hsa002401.87588793
18Basal transcription factors_Homo sapiens_hsa030221.84792407
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.74264651
20Protein export_Homo sapiens_hsa030601.62159841
21mRNA surveillance pathway_Homo sapiens_hsa030151.50520619
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44587537
23Propanoate metabolism_Homo sapiens_hsa006401.36642714
24p53 signaling pathway_Homo sapiens_hsa041151.32287976
25Steroid biosynthesis_Homo sapiens_hsa001001.30863031
26Purine metabolism_Homo sapiens_hsa002301.30444816
27Oocyte meiosis_Homo sapiens_hsa041141.28056113
28Pyruvate metabolism_Homo sapiens_hsa006201.24830315
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22077354
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22055984
31Parkinsons disease_Homo sapiens_hsa050121.19701654
32Biosynthesis of amino acids_Homo sapiens_hsa012301.18499556
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11869855
34Selenocompound metabolism_Homo sapiens_hsa004501.11002481
35Ribosome_Homo sapiens_hsa030101.09790968
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07991198
37Oxidative phosphorylation_Homo sapiens_hsa001901.02679366
38Huntingtons disease_Homo sapiens_hsa050161.01446889
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01424742
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01245418
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99744544
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98423228
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95277645
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88764567
45Fatty acid elongation_Homo sapiens_hsa000620.87892961
46Carbon metabolism_Homo sapiens_hsa012000.84585666
47Systemic lupus erythematosus_Homo sapiens_hsa053220.84491867
48Glutathione metabolism_Homo sapiens_hsa004800.82849300
49Sulfur relay system_Homo sapiens_hsa041220.81584576
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80638036
51Vitamin B6 metabolism_Homo sapiens_hsa007500.70335813
52N-Glycan biosynthesis_Homo sapiens_hsa005100.66973056
53Folate biosynthesis_Homo sapiens_hsa007900.63525033
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60110485
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58682998
56Alcoholism_Homo sapiens_hsa050340.56246933
57Pentose phosphate pathway_Homo sapiens_hsa000300.54706083
58Metabolic pathways_Homo sapiens_hsa011000.53531757
59Epstein-Barr virus infection_Homo sapiens_hsa051690.52089532
60Butanoate metabolism_Homo sapiens_hsa006500.50630563
61Lysine degradation_Homo sapiens_hsa003100.50077373
62Alzheimers disease_Homo sapiens_hsa050100.49027578
63Viral carcinogenesis_Homo sapiens_hsa052030.47789959
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44069399
65TGF-beta signaling pathway_Homo sapiens_hsa043500.38548154
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36863231
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35009688
68Phototransduction_Homo sapiens_hsa047440.34884692
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32973759
70Thyroid cancer_Homo sapiens_hsa052160.29499350
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29162029
72MicroRNAs in cancer_Homo sapiens_hsa052060.28484445
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28424283
74Fatty acid metabolism_Homo sapiens_hsa012120.27583690
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27318361
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.22765276
77Peroxisome_Homo sapiens_hsa041460.21952394
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21616296
79Nitrogen metabolism_Homo sapiens_hsa009100.20368627
80Hippo signaling pathway_Homo sapiens_hsa043900.19074656
81Tryptophan metabolism_Homo sapiens_hsa003800.18580258
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17826323
83Herpes simplex infection_Homo sapiens_hsa051680.16293466
84Vitamin digestion and absorption_Homo sapiens_hsa049770.16102238
85HTLV-I infection_Homo sapiens_hsa051660.15059581
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14415888
87Sulfur metabolism_Homo sapiens_hsa009200.14329676
88Wnt signaling pathway_Homo sapiens_hsa043100.14255432
89Primary immunodeficiency_Homo sapiens_hsa053400.13690231
90Basal cell carcinoma_Homo sapiens_hsa052170.12997506
91Colorectal cancer_Homo sapiens_hsa052100.11528488
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10800548
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.10715717
94Ether lipid metabolism_Homo sapiens_hsa005650.07953690
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07546902
96Small cell lung cancer_Homo sapiens_hsa052220.06908674
97Prostate cancer_Homo sapiens_hsa052150.06833660
98Arginine and proline metabolism_Homo sapiens_hsa003300.05226262
99Adherens junction_Homo sapiens_hsa045200.05056711
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03545713

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