ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	5.65211628
2	epoxygenase P450 pathway (GO:0019373)	5.41870370
3	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.39378611
4	NADH metabolic process (GO:0006734)	5.31068253
5	regulation of bile acid biosynthetic process (GO:0070857)	4.63217553
6	lipoprotein transport (GO:0042953)	4.53040956
7	intestinal absorption (GO:0050892)	4.41337255
8	urea metabolic process (GO:0019627)	4.35176153
9	very-low-density lipoprotein particle assembly (GO:0034379)	4.32446711
10	urea cycle (GO:0000050)	4.20036334
11	fat-soluble vitamin biosynthetic process (GO:0042362)	4.15388390
12	ethanol oxidation (GO:0006069)	4.13044598
13	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.12567767
14	nitrogen cycle metabolic process (GO:0071941)	4.04049178
15	diacylglycerol metabolic process (GO:0046339)	4.01035557
16	regulation of guanylate cyclase activity (GO:0031282)	3.94080849
17	regulation of cholesterol esterification (GO:0010872)	3.89910669
18	cellular glucuronidation (GO:0052695)	3.89630999
19	fructose metabolic process (GO:0006000)	3.87589232
20	drug metabolic process (GO:0017144)	3.84579811
21	positive regulation of triglyceride lipase activity (GO:0061365)	3.82425182
22	positive regulation of lipoprotein lipase activity (GO:0051006)	3.82425182
23	exogenous drug catabolic process (GO:0042738)	3.81985077
24	plasma lipoprotein particle assembly (GO:0034377)	3.76564248
25	drug catabolic process (GO:0042737)	3.71620604
26	glucuronate metabolic process (GO:0019585)	3.71429683
27	uronic acid metabolic process (GO:0006063)	3.71429683
28	regulation of triglyceride catabolic process (GO:0010896)	3.70978798
29	hormone catabolic process (GO:0042447)	3.69217615
30	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.63577694
31	synaptic vesicle maturation (GO:0016188)	3.60726518
32	protein-lipid complex assembly (GO:0065005)	3.60391261
33	glutamate secretion (GO:0014047)	3.57816012
34	phospholipid efflux (GO:0033700)	3.49700928
35	protein-lipid complex remodeling (GO:0034368)	3.43657790
36	macromolecular complex remodeling (GO:0034367)	3.43657790
37	plasma lipoprotein particle remodeling (GO:0034369)	3.43657790
38	sodium ion export (GO:0071436)	3.43157937
39	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.36582926
40	renal system process involved in regulation of blood volume (GO:0001977)	3.36085426
41	bile acid and bile salt transport (GO:0015721)	3.34819952
42	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.32777905
43	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.32777905
44	endocrine process (GO:0050886)	3.32777905
45	regulation of cholesterol homeostasis (GO:2000188)	3.32678197
46	bile acid metabolic process (GO:0008206)	3.32024017
47	ethanol metabolic process (GO:0006067)	3.27170302
48	positive regulation of lipid catabolic process (GO:0050996)	3.23905441
49	negative regulation of fibrinolysis (GO:0051918)	3.23850714
50	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.21874137
51	high-density lipoprotein particle remodeling (GO:0034375)	3.20484632
52	cholesterol efflux (GO:0033344)	3.13434485
53	cellular potassium ion homeostasis (GO:0030007)	3.12895197
54	regulation of protein activation cascade (GO:2000257)	3.11123361
55	glutamine family amino acid biosynthetic process (GO:0009084)	3.09988297
56	oxaloacetate metabolic process (GO:0006107)	3.09225601
57	lipoprotein metabolic process (GO:0042157)	3.06217673
58	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.05689675
59	L-phenylalanine metabolic process (GO:0006558)	3.05689675
60	regulation of fibrinolysis (GO:0051917)	3.03282765
61	positive regulation of guanylate cyclase activity (GO:0031284)	3.03280472
62	L-phenylalanine catabolic process (GO:0006559)	3.02339230
63	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.02339230
64	plasma lipoprotein particle organization (GO:0071827)	3.01504578
65	omega-hydroxylase P450 pathway (GO:0097267)	3.00368695
66	negative regulation of sterol transport (GO:0032372)	2.98929999
67	negative regulation of cholesterol transport (GO:0032375)	2.98929999
68	regulation of complement activation (GO:0030449)	2.97372422
69	protein-lipid complex subunit organization (GO:0071825)	2.97232020
70	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.95253780
71	reverse cholesterol transport (GO:0043691)	2.94041994
72	regulation of systemic arterial blood pressure (GO:0003073)	2.93350525
73	complement activation, alternative pathway (GO:0006957)	2.93070100
74	synaptic vesicle exocytosis (GO:0016079)	2.93030657
75	sodium ion homeostasis (GO:0055078)	2.92853669
76	transcytosis (GO:0045056)	2.92481835
77	low-density lipoprotein particle remodeling (GO:0034374)	2.91015786
78	vitamin transmembrane transport (GO:0035461)	2.90793553
79	regulation of cholesterol metabolic process (GO:0090181)	2.90675083
80	proline metabolic process (GO:0006560)	2.89305444
81	phosphate ion transmembrane transport (GO:0035435)	2.88964548
82	cGMP-mediated signaling (GO:0019934)	2.85090049
83	flavonoid metabolic process (GO:0009812)	2.85078962
84	L-amino acid import (GO:0043092)	2.84577883
85	regulation of synaptic vesicle exocytosis (GO:2000300)	2.82610439
86	drinking behavior (GO:0042756)	2.76214972
87	cellular sodium ion homeostasis (GO:0006883)	2.75479889
88	triglyceride homeostasis (GO:0070328)	2.75277070
89	acylglycerol homeostasis (GO:0055090)	2.75277070
90	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.74924282
91	cholesterol homeostasis (GO:0042632)	2.74588195
92	acylglycerol catabolic process (GO:0046464)	2.72878254
93	neutral lipid catabolic process (GO:0046461)	2.72878254
94	sterol homeostasis (GO:0055092)	2.72858961
95	protein carboxylation (GO:0018214)	2.69659241
96	peptidyl-glutamic acid carboxylation (GO:0017187)	2.69659241
97	complement activation, classical pathway (GO:0006958)	2.68550151
98	regulation of cGMP biosynthetic process (GO:0030826)	2.66726067
99	positive regulation of cellular amine metabolic process (GO:0033240)	2.62420790
100	triglyceride catabolic process (GO:0019433)	2.59624843

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.91156272
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.30197799
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.14163792
4	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.13024966
5	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.03431269
6	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.81112538
7	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.63201366
8	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.59602909
9	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.49483406
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.22207614
11	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.10069516
12	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.08557062
13	DROSHA_22980978_ChIP-Seq_HELA_Human	1.97313759
14	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.94111976
15	* LXR_22292898_ChIP-Seq_THP-1_Human	1.79345694
16	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.72473732
17	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.71388614
18	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.67211412
19	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.67202791
20	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.67178394
21	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.64467568
22	CLOCK_20551151_ChIP-Seq_293T_Human	1.62596708
23	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.60874600
24	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.59841535
25	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.59156022
26	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57585352
27	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57585352
28	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.54912151
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.54383707
30	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.53679648
31	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.51959173
32	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.49437524
33	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.48269577
34	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.44907201
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.44246939
36	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.41434960
37	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.39563453
38	CTCF_27219007_Chip-Seq_Bcells_Human	1.38845336
39	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.36713335
40	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.36635932
41	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.33514449
42	KDM2B_26808549_Chip-Seq_K562_Human	1.31062777
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29861406
44	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.29832452
45	RACK7_27058665_Chip-Seq_MCF-7_Human	1.28978759
46	* SOX2_20726797_ChIP-Seq_SW620_Human	1.28521165
47	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28513611
48	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.26355411
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26150140
50	GATA4_25053715_ChIP-Seq_YYC3_Human	1.25901195
51	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.20781978
52	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.18274175
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17838523
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15262818
55	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.14262448
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13839496
57	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13036406
58	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.11997219
59	GATA6_25053715_ChIP-Seq_YYC3_Human	1.11530694
60	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.10919281
61	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.10541837
62	ZNF263_19887448_ChIP-Seq_K562_Human	1.08431880
63	CREB1_26743006_Chip-Seq_LNCaP_Human	1.05794846
64	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.04610692
65	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.01781645
66	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.01636996
67	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.00319924
68	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00296460
69	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99774989
70	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.99637627
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99620072
72	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95573556
73	SMC4_20622854_ChIP-Seq_HELA_Human	0.95254478
74	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.94873202
75	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.94600013
76	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.94142901
77	EGR1_19032775_ChIP-ChIP_M12_Human	0.92811314
78	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.92486786
79	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92204113
80	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.91967341
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.90323371
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.89392893
83	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.89188143
84	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.88443535
85	SA1_27219007_Chip-Seq_Bcells_Human	0.87686955
86	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.86924576
87	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.86578081
88	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.86554498
89	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86351186
90	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.86248281
91	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.85950124
92	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.85668362
93	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85091161
94	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.84730341
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.84625551
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.84419314
97	* CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.84362799
98	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.84107397
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.83147687
100	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.82500763

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.69146176
2	MP0002139_abnormal_hepatobiliary_system	5.28082534
3	MP0005085_abnormal_gallbladder_physiolo	4.33068621
4	MP0005365_abnormal_bile_salt	4.08526460
5	MP0001666_abnormal_nutrient_absorption	4.08087259
6	MP0004270_analgesia	3.12406555
7	MP0010329_abnormal_lipoprotein_level	2.97826935
8	MP0003183_abnormal_peptide_metabolism	2.82545868
9	MP0004859_abnormal_synaptic_plasticity	2.81557337
10	MP0009840_abnormal_foam_cell	2.64766442
11	MP0003868_abnormal_feces_composition	2.64163412
12	MP0004019_abnormal_vitamin_homeostasis	2.61392636
13	MP0003879_abnormal_hair_cell	2.53403088
14	MP0005670_abnormal_white_adipose	2.38201176
15	MP0005409_darkened_coat_color	2.34445356
16	MP0002876_abnormal_thyroid_physiology	2.16018228
17	MP0010234_abnormal_vibrissa_follicle	2.12265800
18	MP0009780_abnormal_chondrocyte_physiolo	1.94785967
19	MP0001501_abnormal_sleep_pattern	1.91094515
20	MP0003329_amyloid_beta_deposits	1.87354299
21	MP0009379_abnormal_foot_pigmentation	1.86647828
22	MP0008875_abnormal_xenobiotic_pharmacok	1.84966031
23	MP0005332_abnormal_amino_acid	1.84520165
24	MP0004264_abnormal_extraembryonic_tissu	1.82962923
25	MP0004147_increased_porphyrin_level	1.78036877
26	MP0003252_abnormal_bile_duct	1.76641609
27	MP0003880_abnormal_central_pattern	1.75536828
28	MP0002118_abnormal_lipid_homeostasis	1.64388375
29	MP0002064_seizures	1.63236970
30	MP0002971_abnormal_brown_adipose	1.49530358
31	MP0003635_abnormal_synaptic_transmissio	1.45836878
32	MP0005666_abnormal_adipose_tissue	1.38659543
33	MP0003191_abnormal_cellular_cholesterol	1.34587103
34	MP0005166_decreased_susceptibility_to	1.33970518
35	MP0009643_abnormal_urine_homeostasis	1.33959504
36	MP0005535_abnormal_body_temperature	1.32114707
37	MP0001664_abnormal_digestion	1.31963279
38	MP0002734_abnormal_mechanical_nocicepti	1.29412258
39	MP0000604_amyloidosis	1.22797780
40	MP0002822_catalepsy	1.22477783
41	MP0004782_abnormal_surfactant_physiolog	1.19638652
42	MP0002063_abnormal_learning/memory/cond	1.19210185
43	MP0003690_abnormal_glial_cell	1.15395730
44	MP0010368_abnormal_lymphatic_system	1.14640230
45	MP0002272_abnormal_nervous_system	1.13926760
46	MP0001765_abnormal_ion_homeostasis	1.10836307
47	MP0009745_abnormal_behavioral_response	1.10467491
48	MP0000609_abnormal_liver_physiology	1.09818773
49	MP0002138_abnormal_hepatobiliary_system	1.08869973
50	MP0003075_altered_response_to	1.08654652
51	MP0001764_abnormal_homeostasis	1.07899595
52	MP0005636_abnormal_mineral_homeostasis	1.07464822
53	MP0000566_synostosis	1.06751542
54	MP0005448_abnormal_energy_balance	1.06025126
55	MP0004858_abnormal_nervous_system	1.03731159
56	MP0001486_abnormal_startle_reflex	1.03142068
57	MP0003195_calcinosis	1.00553072
58	MP0009115_abnormal_fat_cell	1.00443958
59	MP0000678_abnormal_parathyroid_gland	1.00156772
60	MP0001440_abnormal_grooming_behavior	1.00022254
61	MP0010155_abnormal_intestine_physiology	0.98903811
62	MP0006138_congestive_heart_failure	0.95692955
63	MP0005375_adipose_tissue_phenotype	0.92381946
64	MP0001756_abnormal_urination	0.91045531
65	MP0000920_abnormal_myelination	0.90648589
66	MP0003705_abnormal_hypodermis_morpholog	0.90335881
67	MP0005584_abnormal_enzyme/coenzyme_acti	0.90013647
68	MP0002572_abnormal_emotion/affect_behav	0.89058423
69	MP0005167_abnormal_blood-brain_barrier	0.88502652
70	MP0008569_lethality_at_weaning	0.87115938
71	MP0002909_abnormal_adrenal_gland	0.85385371
72	MP0004043_abnormal_pH_regulation	0.84411467
73	MP0005451_abnormal_body_composition	0.82444963
74	MP0003866_abnormal_defecation	0.81083632
75	MP0005058_abnormal_lysosome_morphology	0.79643414
76	MP0000538_abnormal_urinary_bladder	0.76298256
77	MP0010352_gastrointestinal_tract_polyps	0.75859422
78	MP0002078_abnormal_glucose_homeostasis	0.74339662
79	MP0002733_abnormal_thermal_nociception	0.71696443
80	MP0000462_abnormal_digestive_system	0.69920756
81	MP0005334_abnormal_fat_pad	0.69039089
82	MP0005423_abnormal_somatic_nervous	0.68338737
83	MP0003638_abnormal_response/metabolism_	0.67278922
84	MP0002796_impaired_skin_barrier	0.67194703
85	MP0008874_decreased_physiological_sensi	0.67077867
86	MP0000477_abnormal_intestine_morphology	0.66538466
87	MP0004130_abnormal_muscle_cell	0.66297519
88	MP0008872_abnormal_physiological_respon	0.65758981
89	MP0002089_abnormal_postnatal_growth/wei	0.65342572
90	MP0003633_abnormal_nervous_system	0.64707222
91	MP0001188_hyperpigmentation	0.64253147
92	MP0003123_paternal_imprinting	0.63829278
93	MP0002249_abnormal_larynx_morphology	0.63420936
94	MP0001968_abnormal_touch/_nociception	0.62947401
95	MP0003953_abnormal_hormone_level	0.62719952
96	MP0009642_abnormal_blood_homeostasis	0.62560248
97	MP0002136_abnormal_kidney_physiology	0.62384047
98	MP0005319_abnormal_enzyme/_coenzyme	0.61249966
99	MP0000003_abnormal_adipose_tissue	0.60507513
100	MP0001970_abnormal_pain_threshold	0.60475209

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.69446067
2	Hypobetalipoproteinemia (HP:0003563)	5.54111029
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.14501921
4	Deep venous thrombosis (HP:0002625)	4.89733203
5	Systemic lupus erythematosus (HP:0002725)	4.81061715
6	Hydroxyprolinuria (HP:0003080)	4.77149695
7	Abnormality of proline metabolism (HP:0010907)	4.77149695
8	Complement deficiency (HP:0004431)	4.75373547
9	Malnutrition (HP:0004395)	4.02954189
10	Abnormality of complement system (HP:0005339)	4.01547142
11	Fat malabsorption (HP:0002630)	3.87739191
12	Xanthomatosis (HP:0000991)	3.86216714
13	Glomerulonephritis (HP:0000099)	3.45368034
14	Prolonged partial thromboplastin time (HP:0003645)	3.35769357
15	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.35487522
16	Hyperglycinuria (HP:0003108)	3.34249328
17	Myokymia (HP:0002411)	3.31056600
18	Action tremor (HP:0002345)	3.29471583
19	Confusion (HP:0001289)	3.27312392
20	Hemorrhage of the eye (HP:0011885)	3.16456510
21	Hypolipoproteinemia (HP:0010981)	3.11470345
22	Widely patent fontanelles and sutures (HP:0004492)	3.09389146
23	Joint hemorrhage (HP:0005261)	2.97883388
24	Acanthocytosis (HP:0001927)	2.91237397
25	Ileus (HP:0002595)	2.87731610
26	Ankle clonus (HP:0011448)	2.84092774
27	Conjugated hyperbilirubinemia (HP:0002908)	2.81529906
28	Abnormality of serine family amino acid metabolism (HP:0010894)	2.80296525
29	Abnormality of glycine metabolism (HP:0010895)	2.80296525
30	Focal motor seizures (HP:0011153)	2.64049970
31	Pigmentary retinal degeneration (HP:0001146)	2.64021772
32	Steatorrhea (HP:0002570)	2.63241069
33	Hyperlipoproteinemia (HP:0010980)	2.61479166
34	Abnormality of vitamin metabolism (HP:0100508)	2.61172458
35	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.56780129
36	Intrahepatic cholestasis (HP:0001406)	2.53467901
37	Nephritis (HP:0000123)	2.49832901
38	Epidermoid cyst (HP:0200040)	2.46513654
39	Wide cranial sutures (HP:0010537)	2.41162000
40	Proximal tubulopathy (HP:0000114)	2.41071682
41	Facial shape deformation (HP:0011334)	2.37263498
42	Potter facies (HP:0002009)	2.37263498
43	Hyperammonemia (HP:0001987)	2.36161109
44	Growth hormone excess (HP:0000845)	2.35751653
45	Hypercholesterolemia (HP:0003124)	2.34999139
46	Nephrolithiasis (HP:0000787)	2.30240432
47	Neurofibrillary tangles (HP:0002185)	2.29762027
48	Metabolic alkalosis (HP:0200114)	2.29239091
49	Thin bony cortex (HP:0002753)	2.25439790
50	Hypophosphatemia (HP:0002148)	2.24594226
51	Alkalosis (HP:0001948)	2.21923383
52	Skin nodule (HP:0200036)	2.19650972
53	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.19442269
54	Abnormality of urine glucose concentration (HP:0011016)	2.16800715
55	Glycosuria (HP:0003076)	2.16800715
56	Hyperparathyroidism (HP:0000843)	2.14663764
57	Abnormal eating behavior (HP:0100738)	2.14089573
58	Bronchomalacia (HP:0002780)	2.07983413
59	Focal seizures (HP:0007359)	2.06419752
60	Hyperactive renin-angiotensin system (HP:0000841)	2.05361171
61	Abnormality of purine metabolism (HP:0004352)	2.04963019
62	Hypotension (HP:0002615)	2.04502738
63	Nausea (HP:0002018)	2.03984813
64	Flat acetabular roof (HP:0003180)	2.01941211
65	Rickets (HP:0002748)	2.01216720
66	Abnormality of vitamin B metabolism (HP:0004340)	2.00372990
67	Abnormality of the common coagulation pathway (HP:0010990)	1.99636016
68	Abdominal distention (HP:0003270)	1.98354911
69	Right ventricular cardiomyopathy (HP:0011663)	1.96262844
70	Vascular calcification (HP:0004934)	1.96059402
71	Neonatal onset (HP:0003623)	1.96055877
72	Increased purine levels (HP:0004368)	1.95696021
73	Hyperuricemia (HP:0002149)	1.95696021
74	Megaloblastic anemia (HP:0001889)	1.93927213
75	Focal segmental glomerulosclerosis (HP:0000097)	1.92962474
76	Cerebral inclusion bodies (HP:0100314)	1.92588221
77	Irritability (HP:0000737)	1.91701305
78	Abnormality of nucleobase metabolism (HP:0010932)	1.90807882
79	Amyloidosis (HP:0011034)	1.89787063
80	Spontaneous abortion (HP:0005268)	1.89687418
81	Hyperphosphaturia (HP:0003109)	1.88565018
82	Gout (HP:0001997)	1.88236369
83	Supranuclear gaze palsy (HP:0000605)	1.88181210
84	Abnormal urine phosphate concentration (HP:0012599)	1.88107756
85	Subcapsular cataract (HP:0000523)	1.87186909
86	Abnormality of carpal bone ossification (HP:0006257)	1.86427735
87	Chronic diarrhea (HP:0002028)	1.85343656
88	Febrile seizures (HP:0002373)	1.80439580
89	Abnormal tarsal ossification (HP:0008369)	1.80091963
90	Osteomalacia (HP:0002749)	1.79958778
91	Torticollis (HP:0000473)	1.76778217
92	Atonic seizures (HP:0010819)	1.76768688
93	Akinesia (HP:0002304)	1.76378858
94	Abnormality of renin-angiotensin system (HP:0000847)	1.75939900
95	Decreased circulating renin level (HP:0003351)	1.74791337
96	Epileptic encephalopathy (HP:0200134)	1.73979574
97	Axonal loss (HP:0003447)	1.70904471
98	Delayed CNS myelination (HP:0002188)	1.70629753
99	Intention tremor (HP:0002080)	1.69069333
100	Renal tubular acidosis (HP:0001947)	1.69014182

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	5.49892425
2	RIPK1	4.07827423
3	DAPK2	3.17977372
4	ACVR1B	2.97942401
5	NTRK3	2.68097914
6	ERN1	2.46017562
7	FGFR4	2.40112356
8	TRIB3	2.05778169
9	PAK6	2.01848907
10	MST1R	1.99700559
11	PRKG2	1.99516386
12	RIPK4	1.88609857
13	PRPF4B	1.82850557
14	EPHA2	1.76121225
15	PRKD3	1.68473029
16	CAMKK1	1.62327246
17	MAP3K12	1.53356978
18	LATS2	1.47873117
19	KSR2	1.43681574
20	PDPK1	1.42109695
21	NTRK1	1.38636059
22	PDGFRA	1.34250857
23	DAPK1	1.32288266
24	MAP3K2	1.30312308
25	MINK1	1.23235371
26	GRK5	1.22729409
27	UHMK1	1.22029767
28	AKT3	1.20486085
29	PIK3CA	1.18574301
30	MAP3K9	1.18239903
31	FGFR3	1.17376183
32	ICK	1.14657884
33	TYRO3	1.14423881
34	TESK1	1.13921604
35	LMTK2	1.11851268
36	PDK1	1.08485668
37	OXSR1	1.04787300
38	MAP3K1	0.99034649
39	MAP3K11	0.97280450
40	TIE1	0.96567245
41	SGK223	0.96400527
42	SGK494	0.96400527
43	CDK5	0.96394521
44	ARAF	0.93774324
45	STK39	0.92305622
46	PTK6	0.90643707
47	EEF2K	0.88871359
48	DDR2	0.87188805
49	MARK1	0.87012546
50	ERBB2	0.86218405
51	CAMK2B	0.85624714
52	STK38	0.84982407
53	CAMK1	0.84770073
54	NEK6	0.84069368
55	RET	0.80483456
56	PRKAA2	0.77280364
57	CASK	0.77177900
58	DAPK3	0.75714627
59	MYLK	0.74436129
60	MET	0.71505119
61	PTK2	0.71366322
62	SGK3	0.71316448
63	CAMK2G	0.70528324
64	NTRK2	0.70384760
65	FER	0.69853271
66	PRKCZ	0.68994898
67	CDK19	0.68946711
68	EPHB2	0.66186058
69	BMPR2	0.66091542
70	PRKACG	0.64481232
71	CDC42BPA	0.64262374
72	CDK15	0.64085820
73	DMPK	0.64043379
74	SIK1	0.63518279
75	MAPK12	0.61980000
76	SGK1	0.60539105
77	CDK18	0.58685945
78	CDK11A	0.57739020
79	MARK2	0.57139010
80	MAP2K2	0.53351410
81	SGK2	0.52567400
82	SRC	0.51565932
83	MAP2K6	0.51508674
84	PRKCH	0.50699296
85	CAMK4	0.49556032
86	PRKCA	0.49436870
87	STK11	0.48597589
88	ALK	0.47948327
89	CAMK2A	0.47216158
90	SMG1	0.46556559
91	MAPK11	0.46467171
92	PRKCG	0.46193037
93	CAMKK2	0.45757198
94	CDK14	0.45188106
95	MAP3K13	0.43164491
96	RPS6KA3	0.42872625
97	CAMK2D	0.40903608
98	RPS6KA2	0.39165765
99	FYN	0.39099196
100	MAP2K4	0.38701955

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.50419874
2	Fat digestion and absorption_Homo sapiens_hsa04975	2.90907669
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.74339080
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.66185053
5	Histidine metabolism_Homo sapiens_hsa00340	2.61586768
6	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.50760102
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.50229474
8	Caffeine metabolism_Homo sapiens_hsa00232	2.24908734
9	Renin-angiotensin system_Homo sapiens_hsa04614	2.24088677
10	Bile secretion_Homo sapiens_hsa04976	2.18274441
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.10212016
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.07275853
13	PPAR signaling pathway_Homo sapiens_hsa03320	2.05454077
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.03225784
15	Retinol metabolism_Homo sapiens_hsa00830	1.98422452
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.88854998
17	Fatty acid degradation_Homo sapiens_hsa00071	1.84029625
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.83213568
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.78762463
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.73385409
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69788455
22	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.69457420
23	Mineral absorption_Homo sapiens_hsa04978	1.68371533
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.65265425
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.54937251
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.54116901
27	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.48154429
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.45169080
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.32742025
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.28388181
31	Protein digestion and absorption_Homo sapiens_hsa04974	1.27128469
32	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.25787220
33	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.24274262
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.21413727
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.15714749
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15700043
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.11059373
38	Amphetamine addiction_Homo sapiens_hsa05031	1.07543447
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.05836594
40	Long-term potentiation_Homo sapiens_hsa04720	0.97834018
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96658640
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96129726
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.93299824
44	Galactose metabolism_Homo sapiens_hsa00052	0.93036750
45	Insulin secretion_Homo sapiens_hsa04911	0.91522152
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.91456311
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90411146
48	Butanoate metabolism_Homo sapiens_hsa00650	0.87048510
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.86189862
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84269382
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82035113
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81421890
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79740532
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78161081
55	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.77719809
56	Cocaine addiction_Homo sapiens_hsa05030	0.77681658
57	Renin secretion_Homo sapiens_hsa04924	0.75905894
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73281790
59	Sulfur metabolism_Homo sapiens_hsa00920	0.72994099
60	Pancreatic secretion_Homo sapiens_hsa04972	0.71573711
61	Nicotine addiction_Homo sapiens_hsa05033	0.71283485
62	Prion diseases_Homo sapiens_hsa05020	0.69415063
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68929190
64	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68739396
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68257584
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.67637250
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.66149371
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65084661
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.60620743
70	Peroxisome_Homo sapiens_hsa04146	0.60539806
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58974632
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.57719039
73	ABC transporters_Homo sapiens_hsa02010	0.56972032
74	Gastric acid secretion_Homo sapiens_hsa04971	0.56930832
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.56065505
76	Carbon metabolism_Homo sapiens_hsa01200	0.55765666
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.53854252
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50744005
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50247732
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.47065567
81	Circadian entrainment_Homo sapiens_hsa04713	0.45336498
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44911834
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.44586208
84	Salivary secretion_Homo sapiens_hsa04970	0.43990473
85	GABAergic synapse_Homo sapiens_hsa04727	0.43474022
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43145041
87	Cholinergic synapse_Homo sapiens_hsa04725	0.42674708
88	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41999535
89	Propanoate metabolism_Homo sapiens_hsa00640	0.37989225
90	Insulin resistance_Homo sapiens_hsa04931	0.37714963
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36426010
92	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35443070
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.33797773
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32267170
95	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.31491873
96	Folate biosynthesis_Homo sapiens_hsa00790	0.31271368
97	Serotonergic synapse_Homo sapiens_hsa04726	0.31159268
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30983464
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30285488
100	Sulfur relay system_Homo sapiens_hsa04122	0.29094896

C1ORF115

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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