ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	9.94290326
2	surfactant homeostasis (GO:0043129)	9.86160358
3	chemical homeostasis within a tissue (GO:0048875)	8.56492887
4	keratinization (GO:0031424)	7.43754653
5	establishment of skin barrier (GO:0061436)	7.33272276
6	bundle of His cell to Purkinje myocyte communication (GO:0086069)	7.25840424
7	regulation of water loss via skin (GO:0033561)	7.05501177
8	multicellular organismal water homeostasis (GO:0050891)	6.03980106
9	keratinocyte proliferation (GO:0043616)	5.71054159
10	water homeostasis (GO:0030104)	5.26288282
11	keratinocyte differentiation (GO:0030216)	5.04672649
12	intestinal epithelial cell development (GO:0060576)	4.93478605
13	negative regulation of keratinocyte proliferation (GO:0010839)	4.82329751
14	peptide cross-linking (GO:0018149)	4.79834585
15	cell-substrate junction assembly (GO:0007044)	4.73464001
16	epidermis development (GO:0008544)	4.18018224
17	epidermal cell differentiation (GO:0009913)	4.17798375
18	iron ion import (GO:0097286)	4.09123974
19	regulation of keratinocyte proliferation (GO:0010837)	4.00217388
20	gap junction assembly (GO:0016264)	3.77987033
21	epithelial cell differentiation involved in prostate gland development (GO:0060742)	3.76063732
22	apical protein localization (GO:0045176)	3.62554827
23	protein autoprocessing (GO:0016540)	3.57876892
24	hypotonic response (GO:0006971)	3.56259402
25	positive regulation of epidermal cell differentiation (GO:0045606)	3.48418917
26	intermediate filament organization (GO:0045109)	3.40442540
27	keratinocyte development (GO:0003334)	3.38805772
28	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.35204749
29	endothelial cell chemotaxis (GO:0035767)	3.34926615
30	epithelial cell-cell adhesion (GO:0090136)	3.33685767
31	regulation of keratinocyte differentiation (GO:0045616)	3.27056890
32	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	3.19658908
33	ventricular cardiac muscle cell action potential (GO:0086005)	3.19412922
34	molting cycle (GO:0042303)	3.18790172
35	hair cycle (GO:0042633)	3.18790172
36	protein localization to endosome (GO:0036010)	3.18433462
37	lipoxygenase pathway (GO:0019372)	3.18341572
38	Golgi transport vesicle coating (GO:0048200)	3.13502449
39	COPI coating of Golgi vesicle (GO:0048205)	3.13502449
40	positive regulation of epidermis development (GO:0045684)	3.10726300
41	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.10717674
42	establishment of tissue polarity (GO:0007164)	3.09381872
43	establishment of planar polarity (GO:0001736)	3.09381872
44	asymmetric protein localization (GO:0008105)	3.06794736
45	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.03148975
46	one-carbon compound transport (GO:0019755)	3.01012328
47	columnar/cuboidal epithelial cell development (GO:0002066)	2.99189611
48	positive regulation of keratinocyte differentiation (GO:0045618)	2.98151058
49	diterpenoid biosynthetic process (GO:0016102)	2.95459572
50	tight junction assembly (GO:0070830)	2.94292034
51	regulation of transforming growth factor beta2 production (GO:0032909)	2.93506923
52	polarized epithelial cell differentiation (GO:0030859)	2.91687276
53	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.88515550
54	skin morphogenesis (GO:0043589)	2.84657160
55	ectoderm development (GO:0007398)	2.82510376
56	regulation of transforming growth factor beta1 production (GO:0032908)	2.81099303
57	lung lobe morphogenesis (GO:0060463)	2.79747393
58	mesodermal cell differentiation (GO:0048333)	2.79694972
59	artery development (GO:0060840)	2.79544608
60	cell adhesion mediated by integrin (GO:0033627)	2.78689803
61	phosphate ion transmembrane transport (GO:0035435)	2.77772283
62	O-glycan processing (GO:0016266)	2.76750133
63	branching involved in prostate gland morphogenesis (GO:0060442)	2.73794365
64	cell-cell junction assembly (GO:0007043)	2.69637804
65	cell junction assembly (GO:0034329)	2.66567408
66	regulation of cholesterol homeostasis (GO:2000188)	2.64474573
67	membrane raft organization (GO:0031579)	2.62558402
68	epithelial cell maturation (GO:0002070)	2.62114212
69	activation of Rac GTPase activity (GO:0032863)	2.61081215
70	endosome organization (GO:0007032)	2.60575288
71	import into cell (GO:0098657)	2.59988103
72	glandular epithelial cell differentiation (GO:0002067)	2.57840624
73	negative regulation of stress fiber assembly (GO:0051497)	2.56784493
74	positive regulation of p38MAPK cascade (GO:1900745)	2.55861401
75	cell junction organization (GO:0034330)	2.54597757
76	atrioventricular valve morphogenesis (GO:0003181)	2.53843950
77	linoleic acid metabolic process (GO:0043651)	2.50422048
78	sodium ion homeostasis (GO:0055078)	2.49337087
79	auditory receptor cell differentiation (GO:0042491)	2.48630393
80	regulation of epidermis development (GO:0045682)	2.47555908
81	regulation of protein localization to cell surface (GO:2000008)	2.47041337
82	long-chain fatty acid biosynthetic process (GO:0042759)	2.43821114
83	regulation of cardioblast differentiation (GO:0051890)	2.43813140
84	negative regulation of complement activation (GO:0045916)	2.40374217
85	regulation of integrin-mediated signaling pathway (GO:2001044)	2.37220043
86	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.36818707
87	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.36677723
88	prostate gland epithelium morphogenesis (GO:0060740)	2.36674620
89	biotin metabolic process (GO:0006768)	2.35826785
90	phosphatidylserine metabolic process (GO:0006658)	2.35374165
91	focal adhesion assembly (GO:0048041)	2.34540872
92	cell-substrate adherens junction assembly (GO:0007045)	2.34540872
93	L-serine transport (GO:0015825)	2.34429676
94	semaphorin-plexin signaling pathway (GO:0071526)	2.34258748
95	regulation of epidermal cell differentiation (GO:0045604)	2.34107635
96	regulation of heart rate by cardiac conduction (GO:0086091)	2.32898967
97	regulation of p38MAPK cascade (GO:1900744)	2.31665284
98	renal filtration (GO:0097205)	2.31340498
99	cellular response to nitric oxide (GO:0071732)	2.31313777
100	hemidesmosome assembly (GO:0031581)	10.4558436

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.05686950
2	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	4.12776881
3	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.11931557
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.62333957
5	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.56440984
6	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.55182929
7	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.55182929
8	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.50162794
9	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.44023428
10	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.41240934
11	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	2.37293735
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.25583524
13	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.25281556
14	* SOX2_20726797_ChIP-Seq_SW620_Human	2.23854473
15	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.21899871
16	ZNF263_19887448_ChIP-Seq_K562_Human	2.19202091
17	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.19028859
18	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.14366308
19	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	2.13824385
20	TP63_17297297_ChIP-ChIP_HaCaT_Human	10.3411888
21	RACK7_27058665_Chip-Seq_MCF-7_Human	1.91899239
22	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.90429831
23	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.89822610
24	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.87210109
25	GATA6_25053715_ChIP-Seq_YYC3_Human	1.85668463
26	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.81799159
27	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.77415683
28	* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.77367800
29	* AR_21909140_ChIP-Seq_LNCAP_Human	1.72762458
30	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.71118612
31	CLOCK_20551151_ChIP-Seq_293T_Human	1.67263573
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.67027548
33	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.63009025
34	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.60984874
35	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.60473588
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.57157321
37	* KLF5_25053715_ChIP-Seq_YYC3_Human	1.56912797
38	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.54474273
39	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.54255967
40	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.49721836
41	* TP63_23658742_ChIP-Seq_EP156T_Human	1.49658190
42	* ATF3_27146783_Chip-Seq_COLON_Human	1.48189914
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.46177392
44	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.45467547
45	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.43203356
46	* HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.42732009
47	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.41699943
48	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.38712823
49	* CHD1_26751641_Chip-Seq_LNCaP_Human	1.37556988
50	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.36393105
51	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.33628503
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31276916
53	TP63_22573176_ChIP-Seq_HFKS_Human	1.25454420
54	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.22839692
55	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.22557501
56	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.22501917
57	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.21802506
58	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.20794938
59	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.20715568
60	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.18384540
61	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.16749928
62	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.16572675
63	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.15083681
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12409097
65	CJUN_26792858_Chip-Seq_BT549_Human	1.11524840
66	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10277545
67	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.08769754
68	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.08769754
69	CREB1_26743006_Chip-Seq_LNCaP_Human	1.08234419
70	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04781815
71	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.02085022
72	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.00532604
73	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.98997885
74	LXR_22292898_ChIP-Seq_THP-1_Human	0.97148637
75	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.93475682
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.92195150
77	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91905251
78	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.91711949
79	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.90267275
80	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.90067732
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.85774628
82	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.85245342
83	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.84044069
84	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.82650978
85	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.82208992
86	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.81766214
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.80904380
88	KDM2B_26808549_Chip-Seq_K562_Human	0.80518513
89	* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.80033042
90	TCF7_22412390_ChIP-Seq_EML_Mouse	0.76582776
91	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.76341012
92	* GATA1_19941826_ChIP-Seq_K562_Human	0.75262939
93	AR_21572438_ChIP-Seq_LNCaP_Human	0.75014153
94	ELF5_23300383_ChIP-Seq_T47D_Human	0.74816751
95	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.74418172
96	* GATA2_19941826_ChIP-Seq_K562_Human	0.72791389
97	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.72617561
98	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.72453721
99	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.71998250
100	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.71880646

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	7.47302602
2	MP0002796_impaired_skin_barrier	4.70574521
3	MP0000579_abnormal_nail_morphology	4.36656407
4	MP0004782_abnormal_surfactant_physiolog	3.94671142
5	MP0010678_abnormal_skin_adnexa	3.28997639
6	MP0005275_abnormal_skin_tensile	3.27175363
7	MP0000566_synostosis	3.18414109
8	MP0003453_abnormal_keratinocyte_physiol	2.91089839
9	MP0004264_abnormal_extraembryonic_tissu	2.86388248
10	MP0005501_abnormal_skin_physiology	2.84195516
11	MP0003566_abnormal_cell_adhesion	2.81972314
12	MP0001216_abnormal_epidermal_layer	2.69433601
13	MP0010352_gastrointestinal_tract_polyps	2.61269362
14	MP0003705_abnormal_hypodermis_morpholog	2.53340914
15	MP0000467_abnormal_esophagus_morphology	2.52325468
16	MP0003941_abnormal_skin_development	2.51147610
17	MP0002098_abnormal_vibrissa_morphology	2.39639430
18	MP0000383_abnormal_hair_follicle	2.39012897
19	MP0005409_darkened_coat_color	2.29824319
20	MP0000762_abnormal_tongue_morphology	2.25522175
21	MP0002060_abnormal_skin_morphology	2.25339363
22	MP0000537_abnormal_urethra_morphology	2.21522160
23	MP0009780_abnormal_chondrocyte_physiolo	2.02726965
24	MP0002234_abnormal_pharynx_morphology	1.90392636
25	MP0010771_integument_phenotype	1.88226877
26	MP0000377_abnormal_hair_follicle	1.87749672
27	MP0005023_abnormal_wound_healing	1.83971887
28	MP0004947_skin_inflammation	1.70009017
29	MP0008004_abnormal_stomach_pH	1.69711352
30	MP0002166_altered_tumor_susceptibility	1.65414437
31	MP0000678_abnormal_parathyroid_gland	1.64937822
32	MP0005083_abnormal_biliary_tract	1.62340610
33	MP0001958_emphysema	1.58127463
34	MP0004185_abnormal_adipocyte_glucose	1.34647940
35	MP0003315_abnormal_perineum_morphology	1.33767759
36	MP0003191_abnormal_cellular_cholesterol	1.31668394
37	MP0002006_tumorigenesis	1.29296702
38	MP0004272_abnormal_basement_membrane	1.28789352
39	MP0005360_urolithiasis	1.28349590
40	MP0004858_abnormal_nervous_system	1.26980394
41	MP0009053_abnormal_anal_canal	1.23448004
42	MP0001849_ear_inflammation	1.22212184
43	MP0004043_abnormal_pH_regulation	1.21016913
44	MP0005451_abnormal_body_composition	1.20871167
45	MP0009931_abnormal_skin_appearance	1.19963931
46	MP0004381_abnormal_hair_follicle	1.19229197
47	MP0001765_abnormal_ion_homeostasis	1.12822510
48	MP0004019_abnormal_vitamin_homeostasis	1.10485046
49	MP0000627_abnormal_mammary_gland	1.08711519
50	MP0002009_preneoplasia	1.02101176
51	MP0001851_eye_inflammation	1.00871953
52	MP0003091_abnormal_cell_migration	0.95025876
53	MP0005666_abnormal_adipose_tissue	0.94501842
54	MP0000367_abnormal_coat/_hair	0.89784690
55	MP0005076_abnormal_cell_differentiation	0.87791398
56	MP0001191_abnormal_skin_condition	0.83847366
57	MP0001666_abnormal_nutrient_absorption	0.83099849
58	MP0003045_fibrosis	0.81385464
59	MP0009643_abnormal_urine_homeostasis	0.81136924
60	MP0001756_abnormal_urination	0.80727365
61	MP0000613_abnormal_salivary_gland	0.78068059
62	MP0005375_adipose_tissue_phenotype	0.77879246
63	MP0000470_abnormal_stomach_morphology	0.77506027
64	MP0005310_abnormal_salivary_gland	0.77179075
65	MP0005085_abnormal_gallbladder_physiolo	0.76682047
66	MP0008961_abnormal_basal_metabolism	0.74405093
67	MP0000462_abnormal_digestive_system	0.73534261
68	MP0002133_abnormal_respiratory_system	0.72694140
69	MP0005388_respiratory_system_phenotype	0.72694140
70	MP0001664_abnormal_digestion	0.71451444
71	MP0008260_abnormal_autophagy	0.69323007
72	MP0006138_congestive_heart_failure	0.67934609
73	MP0002909_abnormal_adrenal_gland	0.67686332
74	MP0005164_abnormal_response_to	0.67514646
75	MP0000465_gastrointestinal_hemorrhage	0.66617456
76	MP0009840_abnormal_foam_cell	0.64797005
77	MP0000003_abnormal_adipose_tissue	0.64723850
78	MP0003950_abnormal_plasma_membrane	0.64329443
79	MP0000477_abnormal_intestine_morphology	0.63925973
80	MP0001873_stomach_inflammation	0.63880721
81	MP0010368_abnormal_lymphatic_system	0.63498947
82	MP0000427_abnormal_hair_cycle	0.61597218
83	MP0002136_abnormal_kidney_physiology	0.60920379
84	MP0000647_abnormal_sebaceous_gland	0.60756737
85	MP0004883_abnormal_blood_vessel	0.58717828
86	MP0005365_abnormal_bile_salt	0.57718146
87	MP0002896_abnormal_bone_mineralization	0.56146685
88	MP0005166_decreased_susceptibility_to	0.55097286
89	MP0010155_abnormal_intestine_physiology	0.53787139
90	MP0000538_abnormal_urinary_bladder	0.52798757
91	MP0003828_pulmonary_edema	0.51504950
92	MP0005636_abnormal_mineral_homeostasis	0.51421445
93	MP0005367_renal/urinary_system_phenotyp	0.51243540
94	MP0000516_abnormal_urinary_system	0.51243540
95	MP0001879_abnormal_lymphatic_vessel	0.50263445
96	MP0005165_increased_susceptibility_to	0.45724100
97	MP0000858_altered_metastatic_potential	0.45692609
98	MP0003638_abnormal_response/metabolism_	0.44212498
99	MP0002118_abnormal_lipid_homeostasis	0.42378903
100	MP0005248_abnormal_Harderian_gland	0.41688927

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Plantar hyperkeratosis (HP:0007556)	6.39979816
2	Onycholysis (HP:0001806)	6.33980340
3	Abnormality of nail color (HP:0100643)	6.31494748
4	Milia (HP:0001056)	6.24533766
5	Right ventricular cardiomyopathy (HP:0011663)	5.71467875
6	Palmoplantar hyperkeratosis (HP:0000972)	5.40024584
7	Alopecia of scalp (HP:0002293)	5.39547130
8	Fragile nails (HP:0001808)	5.38342717
9	Interstitial pulmonary disease (HP:0006530)	5.07160359
10	Palmar hyperkeratosis (HP:0010765)	5.06274554
11	Thick nail (HP:0001805)	5.05806509
12	Lip pit (HP:0100267)	4.69599444
13	Nail dystrophy (HP:0008404)	4.11631656
14	Atrophic scars (HP:0001075)	4.03351253
15	Hyperactive renin-angiotensin system (HP:0000841)	4.02380735
16	Pili torti (HP:0003777)	3.84497939
17	Abnormality of the axillary hair (HP:0100134)	3.70733754
18	Abnormality of secondary sexual hair (HP:0009888)	3.70733754
19	Abnormal blistering of the skin (HP:0008066)	3.49194669
20	Ridged nail (HP:0001807)	3.39630211
21	Hypoplasia of dental enamel (HP:0006297)	3.37972376
22	Woolly hair (HP:0002224)	3.33701390
23	Abnormal hair laboratory examination (HP:0003328)	3.30569329
24	Popliteal pterygium (HP:0009756)	3.19736827
25	Hypotrichosis (HP:0001006)	3.13813132
26	Advanced eruption of teeth (HP:0006288)	3.09166624
27	Oral leukoplakia (HP:0002745)	3.04564702
28	Sparse scalp hair (HP:0002209)	3.03101297
29	Erythema (HP:0010783)	2.95270761
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.89829391
31	Abnormality of the salivary glands (HP:0010286)	2.86126205
32	Flat acetabular roof (HP:0003180)	2.84135368
33	Chronic bronchitis (HP:0004469)	2.79561807
34	Natal tooth (HP:0000695)	2.78657255
35	Increased IgE level (HP:0003212)	2.77663810
36	Hypoplastic labia majora (HP:0000059)	2.76122063
37	Amelogenesis imperfecta (HP:0000705)	2.73025742
38	Hyperkalemia (HP:0002153)	2.65423893
39	Malnutrition (HP:0004395)	2.59259843
40	Corneal erosion (HP:0200020)	2.54524089
41	Absent eyelashes (HP:0000561)	2.53969203
42	Pterygium (HP:0001059)	2.52800428
43	Abnormality of the labia majora (HP:0012881)	2.48719027
44	Oligodontia (HP:0000677)	2.47804229
45	Sparse eyelashes (HP:0000653)	2.47040800
46	Broad face (HP:0000283)	2.43890866
47	Dehydration (HP:0001944)	2.38811360
48	Curly hair (HP:0002212)	2.31131812
49	Abnormality of the dental root (HP:0006486)	2.30939397
50	Taurodontia (HP:0000679)	2.30939397
51	Abnormality of permanent molar morphology (HP:0011071)	2.30939397
52	Laryngomalacia (HP:0001601)	2.26687570
53	Abnormality of the distal phalanges of the toes (HP:0010182)	2.24442081
54	Septate vagina (HP:0001153)	2.20291920
55	Ectropion (HP:0000656)	2.15945960
56	Decreased circulating renin level (HP:0003351)	2.14582226
57	Ankyloglossia (HP:0010296)	2.14440014
58	Palmoplantar keratoderma (HP:0000982)	2.12349432
59	Vascular calcification (HP:0004934)	2.12311234
60	Abnormality of chloride homeostasis (HP:0011422)	2.12031894
61	Abnormality of molar morphology (HP:0011070)	2.10454439
62	Abnormality of molar (HP:0011077)	2.10454439
63	Abnormality of the fingertips (HP:0001211)	2.10404591
64	Abnormality of the dental pulp (HP:0006479)	2.09467107
65	Erythroderma (HP:0001019)	2.09393883
66	Pustule (HP:0200039)	2.08547105
67	Fragile skin (HP:0001030)	2.08422141
68	Renal salt wasting (HP:0000127)	2.07513661
69	Anonychia (HP:0001798)	2.06195770
70	Abnormality of the gastric mucosa (HP:0004295)	2.04353636
71	Short nail (HP:0001799)	2.00477311
72	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.00170848
73	Osteolytic defects of the hand bones (HP:0009699)	2.00170848
74	Focal segmental glomerulosclerosis (HP:0000097)	1.96919201
75	Absent hair (HP:0002298)	1.96067418
76	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.94608449
77	Acanthosis nigricans (HP:0000956)	1.94152519
78	Abnormality of renin-angiotensin system (HP:0000847)	1.91794450
79	Hoarse voice (HP:0001609)	1.89129505
80	Glomerulosclerosis (HP:0000096)	1.88423744
81	Dry hair (HP:0011359)	1.87371571
82	Blepharitis (HP:0000498)	1.85216195
83	Axonal loss (HP:0003447)	1.85011985
84	Abnormality of small intestinal villus morphology (HP:0011472)	1.82941855
85	Villous atrophy (HP:0011473)	1.82941855
86	Hyperaldosteronism (HP:0000859)	1.80418960
87	Cardiovascular calcification (HP:0011915)	1.79903952
88	Hypodontia (HP:0000668)	1.79651335
89	Selective tooth agenesis (HP:0001592)	1.79054084
90	Germ cell neoplasia (HP:0100728)	1.77893644
91	Abnormality of the neuromuscular junction (HP:0003398)	1.75803983
92	Fatigable weakness (HP:0003473)	1.75803983
93	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.71837473
94	Amniotic constriction ring (HP:0009775)	1.67748894
95	Abnormality of placental membranes (HP:0011409)	1.67748894
96	Growth hormone excess (HP:0000845)	1.66444395
97	Obstructive sleep apnea (HP:0002870)	1.65764753
98	Neonatal death (HP:0003811)	1.65144336
99	Carious teeth (HP:0000670)	1.63776604
100	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.62861267

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	6.14514742
2	MST1R	5.19165726
3	CAMK1D	3.69881925
4	MET	3.00625668
5	TAOK1	2.98135374
6	CAMK1G	2.90138262
7	FER	2.61782845
8	MAP3K2	2.44778599
9	RIPK1	2.40309465
10	LMTK2	2.36274872
11	AKT3	2.16346656
12	MST4	2.16185970
13	ERN1	2.06545817
14	TRIB3	2.06519368
15	LATS1	2.02442038
16	MAP3K9	1.89382618
17	EPHB2	1.88718209
18	SIK1	1.82432122
19	CDK12	1.61521692
20	MAP3K3	1.53765726
21	STK24	1.48451218
22	PTK2	1.48310188
23	ARAF	1.46944305
24	EPHB1	1.46529507
25	PRKD2	1.43104933
26	PIM2	1.34799728
27	PRKD3	1.32940715
28	EEF2K	1.30537366
29	MARK2	1.30379204
30	MAPKAPK3	1.25641987
31	SMG1	1.19097618
32	MAPK15	1.18698168
33	IRAK3	1.15180166
34	PAK4	1.05547256
35	STK39	1.02395986
36	LATS2	0.96109210
37	TESK1	0.95574538
38	SGK3	0.95296932
39	TRPM7	0.89987111
40	NTRK1	0.89338283
41	STK38L	0.88649279
42	LRRK2	0.88114203
43	TNK2	0.88017649
44	PRKCI	0.87887655
45	PDGFRB	0.87852707
46	STK38	0.84863613
47	PTK6	0.82594415
48	WNK1	0.81217762
49	MTOR	0.80311565
50	CDC42BPA	0.79029481
51	SGK223	0.77488138
52	SGK494	0.77488138
53	MAP3K1	0.76827679
54	PDGFRA	0.76349582
55	MAP3K6	0.76271977
56	MAP3K12	0.75346908
57	EPHA3	0.75298650
58	ICK	0.73805348
59	TGFBR2	0.69893906
60	RPS6KA2	0.67721051
61	TGFBR1	0.67124576
62	SGK2	0.61001928
63	BMX	0.60325153
64	PRKAA2	0.59078130
65	FGFR3	0.58030268
66	MYLK	0.56857308
67	IRAK1	0.55813423
68	STK3	0.53129783
69	BCR	0.51071114
70	PDPK1	0.47862312
71	IRAK2	0.46600249
72	HIPK2	0.45617580
73	MAP3K13	0.43151141
74	ZAP70	0.41575645
75	ERBB2	0.39749204
76	KSR2	0.39018040
77	DMPK	0.38555876
78	STK10	0.38367362
79	PKN2	0.37021538
80	PRKD1	0.36739054
81	FGFR4	0.35186124
82	PRKG2	0.34626540
83	YES1	0.34176281
84	MAP2K6	0.32508138
85	CHUK	0.31968038
86	GSK3A	0.31899695
87	NME1	0.31087559
88	RET	0.26925798
89	WNK4	0.26850814
90	NLK	0.25264977
91	NEK6	0.24179499
92	ILK	0.23546474
93	MAP3K7	0.23473164
94	ERBB3	0.22399575
95	PRKAA1	0.21946169
96	RAF1	0.20609437
97	MAP2K1	0.19607114
98	EIF2AK1	0.18338636
99	BRAF	0.16391518
100	PAK2	0.16378073

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.22346740
2	Histidine metabolism_Homo sapiens_hsa00340	2.28948523
3	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.26421909
4	ECM-receptor interaction_Homo sapiens_hsa04512	2.23330468
5	Adherens junction_Homo sapiens_hsa04520	2.17787171
6	Mineral absorption_Homo sapiens_hsa04978	1.97365980
7	Phenylalanine metabolism_Homo sapiens_hsa00360	1.91099574
8	Tight junction_Homo sapiens_hsa04530	1.73780230
9	Renin-angiotensin system_Homo sapiens_hsa04614	1.70969675
10	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.59904050
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59590583
12	Sphingolipid metabolism_Homo sapiens_hsa00600	1.53921493
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.46409671
14	Sulfur metabolism_Homo sapiens_hsa00920	1.45689397
15	Thyroid cancer_Homo sapiens_hsa05216	1.45681871
16	Notch signaling pathway_Homo sapiens_hsa04330	1.42834592
17	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.39115668
18	Circadian rhythm_Homo sapiens_hsa04710	1.38457154
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.36005056
20	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.32568771
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.30260348
22	Amoebiasis_Homo sapiens_hsa05146	1.29285738
23	Focal adhesion_Homo sapiens_hsa04510	1.27307171
24	Small cell lung cancer_Homo sapiens_hsa05222	1.23842387
25	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.16980602
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15606368
27	Hepatitis C_Homo sapiens_hsa05160	1.13966070
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12333889
29	Bladder cancer_Homo sapiens_hsa05219	1.09334916
30	Pancreatic secretion_Homo sapiens_hsa04972	1.09145369
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07956862
32	Prostate cancer_Homo sapiens_hsa05215	1.05748909
33	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.05181744
34	Bile secretion_Homo sapiens_hsa04976	1.05037139
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03890299
36	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.02573626
37	Renal cell carcinoma_Homo sapiens_hsa05211	0.98455496
38	Ether lipid metabolism_Homo sapiens_hsa00565	0.97473007
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.97338434
40	Insulin signaling pathway_Homo sapiens_hsa04910	0.97329086
41	Insulin resistance_Homo sapiens_hsa04931	0.96459224
42	Arginine biosynthesis_Homo sapiens_hsa00220	0.95227853
43	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.94491438
44	Proteoglycans in cancer_Homo sapiens_hsa05205	0.93930005
45	Steroid biosynthesis_Homo sapiens_hsa00100	0.92210160
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90275416
47	VEGF signaling pathway_Homo sapiens_hsa04370	0.89785359
48	GnRH signaling pathway_Homo sapiens_hsa04912	0.88807102
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88137702
50	Endometrial cancer_Homo sapiens_hsa05213	0.87072043
51	Renin secretion_Homo sapiens_hsa04924	0.86847285
52	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86455392
53	Protein digestion and absorption_Homo sapiens_hsa04974	0.85615557
54	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.82806607
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82707549
56	Endocytosis_Homo sapiens_hsa04144	0.81790623
57	ErbB signaling pathway_Homo sapiens_hsa04012	0.81016109
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79557697
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.79257254
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.78340247
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78014517
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76380626
63	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.75751602
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75525652
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75288969
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.74999187
67	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.74875282
68	Retinol metabolism_Homo sapiens_hsa00830	0.74486308
69	ABC transporters_Homo sapiens_hsa02010	0.74175197
70	Acute myeloid leukemia_Homo sapiens_hsa05221	0.73427181
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72589388
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.68817793
73	Salivary secretion_Homo sapiens_hsa04970	0.68337155
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.67363365
75	Lysosome_Homo sapiens_hsa04142	0.67157548
76	Pancreatic cancer_Homo sapiens_hsa05212	0.66909408
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66378183
78	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65703243
79	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64120336
80	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.63946637
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.63409806
82	Fatty acid degradation_Homo sapiens_hsa00071	0.63070232
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.62116288
84	Toxoplasmosis_Homo sapiens_hsa05145	0.62074982
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.61082903
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60369255
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.58324266
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56988904
89	Galactose metabolism_Homo sapiens_hsa00052	0.56398183
90	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.55887216
91	mTOR signaling pathway_Homo sapiens_hsa04150	0.55523408
92	Pertussis_Homo sapiens_hsa05133	0.54776439
93	Platelet activation_Homo sapiens_hsa04611	0.53557556
94	Salmonella infection_Homo sapiens_hsa05132	0.51475000
95	Axon guidance_Homo sapiens_hsa04360	0.50935358
96	Estrogen signaling pathway_Homo sapiens_hsa04915	0.50507483
97	Pathways in cancer_Homo sapiens_hsa05200	0.49970850
98	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.49555028
99	MicroRNAs in cancer_Homo sapiens_hsa05206	0.47802992
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46746576

C1ORF116

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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