ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.46035314
2	chaperone-mediated protein transport (GO:0072321)	4.71167282
3	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.45813517
4	viral transcription (GO:0019083)	4.32235232
5	translational termination (GO:0006415)	3.94286097
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.78120128
7	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.66878163
8	substrate-independent telencephalic tangential migration (GO:0021826)	3.66878163
9	adhesion of symbiont to host cell (GO:0044650)	3.50378090
10	virion attachment to host cell (GO:0019062)	3.50378090
11	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.49390481
12	skeletal muscle organ development (GO:0060538)	3.41197717
13	protein targeting to ER (GO:0045047)	3.40512825
14	positive regulation of T cell apoptotic process (GO:0070234)	3.37664176
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.35259353
16	cotranslational protein targeting to membrane (GO:0006613)	3.31766336
17	protein localization to endoplasmic reticulum (GO:0070972)	3.29902167
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.27351653
19	ATP synthesis coupled proton transport (GO:0015986)	3.27351653
20	translational elongation (GO:0006414)	3.26474293
21	viral life cycle (GO:0019058)	3.25075275
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.24419050
23	tooth mineralization (GO:0034505)	3.19140702
24	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.17332393
25	activation of MAPKKK activity (GO:0000185)	3.11324638
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.07555612
27	positive regulation of neurotransmitter transport (GO:0051590)	3.06807864
28	regulation of vitamin D biosynthetic process (GO:0060556)	3.02771630
29	cellular protein complex disassembly (GO:0043624)	3.00704049
30	maturation of SSU-rRNA (GO:0030490)	3.00345458
31	respiratory electron transport chain (GO:0022904)	2.99749864
32	establishment of mitochondrion localization (GO:0051654)	2.97625739
33	positive regulation of calcium ion import (GO:0090280)	2.97278967
34	positive regulation of heat generation (GO:0031652)	2.96887033
35	protein neddylation (GO:0045116)	2.96477245
36	regulation of early endosome to late endosome transport (GO:2000641)	2.96227163
37	adhesion of symbiont to host (GO:0044406)	2.95757095
38	diaphragm development (GO:0060539)	2.95311329
39	response to acidic pH (GO:0010447)	2.93666360
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.92103823
41	electron transport chain (GO:0022900)	2.92059871
42	locomotory exploration behavior (GO:0035641)	2.88739770
43	regulation of mononuclear cell migration (GO:0071675)	2.88126241
44	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.84000975
45	ATP hydrolysis coupled proton transport (GO:0015991)	2.84000975
46	glial cell migration (GO:0008347)	2.80941640
47	cell-cell junction maintenance (GO:0045217)	2.77735675
48	GTP biosynthetic process (GO:0006183)	2.77653746
49	positive regulation of neurotransmitter secretion (GO:0001956)	2.74712133
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.71527311
51	synaptic transmission, dopaminergic (GO:0001963)	2.69377756
52	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.68785534
53	mitochondrion transport along microtubule (GO:0047497)	2.68785534
54	protein maturation by protein folding (GO:0022417)	2.66596946
55	ribosomal small subunit assembly (GO:0000028)	2.66097391
56	protein complex biogenesis (GO:0070271)	2.62892566
57	neurofilament cytoskeleton organization (GO:0060052)	2.62066119
58	regulation of fever generation (GO:0031620)	2.60322049
59	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.57266170
60	response to dietary excess (GO:0002021)	2.56314795
61	phagosome maturation (GO:0090382)	2.55765220
62	transferrin transport (GO:0033572)	2.55466910
63	cellular response to zinc ion (GO:0071294)	2.54920684
64	negative regulation of catenin import into nucleus (GO:0035414)	2.51499102
65	cellular response to cadmium ion (GO:0071276)	2.49119751
66	protein targeting to membrane (GO:0006612)	2.48936841
67	protein complex disassembly (GO:0043241)	2.48728201
68	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.48414505
69	hypothalamus development (GO:0021854)	2.46404687
70	hydrogen ion transmembrane transport (GO:1902600)	2.46242193
71	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.44439400
72	neuromuscular process controlling posture (GO:0050884)	2.44186354
73	viral protein processing (GO:0019082)	2.44167395
74	UTP biosynthetic process (GO:0006228)	2.43525273
75	negative regulation of amino acid transport (GO:0051956)	2.42815281
76	central nervous system myelination (GO:0022010)	2.42736436
77	axon ensheathment in central nervous system (GO:0032291)	2.42736436
78	axon extension (GO:0048675)	2.42585488
79	establishment of protein localization to mitochondrion (GO:0072655)	2.42252116
80	regulation of cholesterol storage (GO:0010885)	2.42103196
81	cellular response to nicotine (GO:0071316)	2.41612186
82	axonal fasciculation (GO:0007413)	2.40044021
83	positive regulation of chemokine biosynthetic process (GO:0045080)	2.39930790
84	glycerophospholipid catabolic process (GO:0046475)	2.39213433
85	body morphogenesis (GO:0010171)	2.37880091
86	cellular potassium ion homeostasis (GO:0030007)	2.36650401
87	protein insertion into membrane (GO:0051205)	2.35932427
88	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.35529903
89	synaptic vesicle maturation (GO:0016188)	2.34449764
90	circadian sleep/wake cycle process (GO:0022410)	2.33994259
91	glycosphingolipid catabolic process (GO:0046479)	2.32731195
92	regulation of podosome assembly (GO:0071801)	2.32406891
93	protein targeting to mitochondrion (GO:0006626)	2.32312880
94	uterus development (GO:0060065)	2.31997283
95	cerebellar Purkinje cell layer development (GO:0021680)	2.31132952
96	protein retention in ER lumen (GO:0006621)	2.30985730
97	regulation of synapse structural plasticity (GO:0051823)	2.30409989
98	monocyte chemotaxis (GO:0002548)	2.29993424
99	macromolecular complex disassembly (GO:0032984)	2.28378930
100	positive regulation of gastrulation (GO:2000543)	2.28275528

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.77519485
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.78917443
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.74531607
4	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.65272060
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.55233483
6	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.45363198
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.34218719
8	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.24697484
9	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.09571917
10	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.03612408
11	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.99587507
12	VDR_21846776_ChIP-Seq_THP-1_Human	1.94982421
13	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93189686
14	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.93134795
15	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.82430658
16	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.82198914
17	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.78647388
18	KDM2B_26808549_Chip-Seq_K562_Human	1.76278638
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.75397849
20	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.74205788
21	P68_20966046_ChIP-Seq_HELA_Human	1.71628244
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.69982806
23	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67847989
24	CTCF_27219007_Chip-Seq_Bcells_Human	1.67367943
25	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.67132850
26	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.66456904
27	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.66306224
28	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.65491664
29	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.61844468
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.58513819
31	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.58280099
32	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.58014709
33	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.57271326
34	RACK7_27058665_Chip-Seq_MCF-7_Human	1.54981257
35	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.54415796
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.50946711
37	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.50620627
38	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.48552507
39	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.48238837
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.46732006
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.46552329
42	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.46337169
43	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.46067654
44	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.46067654
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42252309
46	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.42232003
47	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42193460
48	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.40761709
49	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.38170056
50	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.37445117
51	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.37323444
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36433467
53	SA1_27219007_Chip-Seq_Bcells_Human	1.36256464
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.33455867
55	SMC4_20622854_ChIP-Seq_HELA_Human	1.32278634
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29498538
57	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.28536269
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.28074509
59	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.27206596
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.26488646
61	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.26049260
62	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.25979529
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.25031414
64	* TP53_22127205_ChIP-Seq_IMR90_Human	1.24725986
65	BCOR_27268052_Chip-Seq_Bcells_Human	1.23930024
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23648614
67	KDM2B_26808549_Chip-Seq_DND41_Human	1.23369448
68	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.21901188
69	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.19144197
70	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.18767040
71	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17802602
72	XRN2_22483619_ChIP-Seq_HELA_Human	1.17719556
73	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.16524733
74	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.16013887
75	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15021258
76	CREB1_26743006_Chip-Seq_LNCaP_Human	1.14676574
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.14437295
78	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.13472999
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13279160
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12849520
81	ZNF263_19887448_ChIP-Seq_K562_Human	1.12148192
82	PHF8_20622854_ChIP-Seq_HELA_Human	1.11906863
83	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.11730316
84	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.10298924
85	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10183880
86	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.06920810
87	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.06212171
88	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.06135539
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04016645
90	E2F1_20622854_ChIP-Seq_HELA_Human	1.03972363
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03750060
92	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.02787861
93	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.01897925
94	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.01310513
95	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01309913
96	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.99614601
97	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99387703
98	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.98828697
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98566712
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98285292

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003123_paternal_imprinting	4.05927237
2	MP0005058_abnormal_lysosome_morphology	3.47558186
3	MP0009379_abnormal_foot_pigmentation	3.34820019
4	MP0009840_abnormal_foam_cell	3.19648712
5	MP0004510_myositis	2.72638210
6	MP0000343_altered_response_to	2.55748848
7	MP0002653_abnormal_ependyma_morphology	2.50749727
8	MP0004858_abnormal_nervous_system	2.50393066
9	MP0003329_amyloid_beta_deposits	2.47940116
10	MP0002837_dystrophic_cardiac_calcinosis	2.18749354
11	MP0003303_peritoneal_inflammation	2.13421386
12	MP0000604_amyloidosis	2.13232085
13	MP0002163_abnormal_gland_morphology	2.09910001
14	MP0003787_abnormal_imprinting	2.06321428
15	MP0004859_abnormal_synaptic_plasticity	1.96334724
16	MP0005423_abnormal_somatic_nervous	1.94164806
17	MP0001542_abnormal_bone_strength	1.91941037
18	MP0005257_abnormal_intraocular_pressure	1.85334467
19	MP0009278_abnormal_bone_marrow	1.83211151
20	MP0003879_abnormal_hair_cell	1.83024308
21	MP0003186_abnormal_redox_activity	1.80580008
22	MP0005379_endocrine/exocrine_gland_phen	1.73139688
23	MP0003075_altered_response_to	1.68199834
24	MP0001905_abnormal_dopamine_level	1.65547335
25	MP0003122_maternal_imprinting	1.64554000
26	MP0002139_abnormal_hepatobiliary_system	1.60734211
27	MP0003880_abnormal_central_pattern	1.54134410
28	MP0009046_muscle_twitch	1.53242999
29	MP0009764_decreased_sensitivity_to	1.50806486
30	MP0000750_abnormal_muscle_regeneration	1.48639408
31	MP0002148_abnormal_hypersensitivity_rea	1.45155479
32	MP0003806_abnormal_nucleotide_metabolis	1.43306126
33	MP0003634_abnormal_glial_cell	1.43102569
34	MP0001970_abnormal_pain_threshold	1.41217184
35	MP0002064_seizures	1.40968760
36	MP0003172_abnormal_lysosome_physiology	1.40201271
37	MP0006276_abnormal_autonomic_nervous	1.36745797
38	MP0000955_abnormal_spinal_cord	1.35614118
39	MP0006082_CNS_inflammation	1.34493361
40	MP0004142_abnormal_muscle_tone	1.33214901
41	MP0001853_heart_inflammation	1.26388486
42	MP0002063_abnormal_learning/memory/cond	1.24547366
43	MP0000778_abnormal_nervous_system	1.23625071
44	MP0002733_abnormal_thermal_nociception	1.23287568
45	MP0003635_abnormal_synaptic_transmissio	1.23082305
46	MP0001919_abnormal_reproductive_system	1.16746700
47	MP0003011_delayed_dark_adaptation	1.14231951
48	MP0002272_abnormal_nervous_system	1.12883409
49	MP0005167_abnormal_blood-brain_barrier	1.12520269
50	MP0009745_abnormal_behavioral_response	1.08467855
51	MP0000920_abnormal_myelination	1.08444352
52	MP0003121_genomic_imprinting	1.07850341
53	MP0003453_abnormal_keratinocyte_physiol	1.06241590
54	MP0004811_abnormal_neuron_physiology	1.06096871
55	MP0001727_abnormal_embryo_implantation	1.04909034
56	MP0003633_abnormal_nervous_system	1.04877289
57	MP0001440_abnormal_grooming_behavior	1.03145489
58	MP0006292_abnormal_olfactory_placode	1.03023068
59	MP0002557_abnormal_social/conspecific_i	1.02126622
60	MP0002734_abnormal_mechanical_nocicepti	1.01922034
61	MP0002882_abnormal_neuron_morphology	1.00827228
62	MP0002572_abnormal_emotion/affect_behav	0.98484695
63	MP0002909_abnormal_adrenal_gland	0.94973473
64	MP0004270_analgesia	0.91678855
65	MP0009785_altered_susceptibility_to	0.91353035
66	MP0010030_abnormal_orbit_morphology	0.90906128
67	MP0005499_abnormal_olfactory_system	0.90175936
68	MP0005394_taste/olfaction_phenotype	0.90175936
69	MP0003646_muscle_fatigue	0.89643304
70	MP0002184_abnormal_innervation	0.89025489
71	MP0005646_abnormal_pituitary_gland	0.87921388
72	MP0003690_abnormal_glial_cell	0.87613089
73	MP0003942_abnormal_urinary_system	0.87224054
74	MP0002254_reproductive_system_inflammat	0.86982066
75	MP0004133_heterotaxia	0.86703826
76	MP0004130_abnormal_muscle_cell	0.86436158
77	MP0002736_abnormal_nociception_after	0.85111527
78	MP0002229_neurodegeneration	0.84969410
79	MP0003136_yellow_coat_color	0.83794695
80	MP0008874_decreased_physiological_sensi	0.82768986
81	MP0008789_abnormal_olfactory_epithelium	0.82667819
82	MP0001188_hyperpigmentation	0.81907129
83	MP0002638_abnormal_pupillary_reflex	0.80742685
84	MP0002822_catalepsy	0.79852104
85	MP0003279_aneurysm	0.79673510
86	MP0002090_abnormal_vision	0.79525873
87	MP0001502_abnormal_circadian_rhythm	0.77398607
88	MP0000026_abnormal_inner_ear	0.76361382
89	MP0004019_abnormal_vitamin_homeostasis	0.74985088
90	MP0005195_abnormal_posterior_eye	0.73995405
91	MP0000049_abnormal_middle_ear	0.73495770
92	MP0009053_abnormal_anal_canal	0.73216771
93	MP0001663_abnormal_digestive_system	0.72804462
94	MP0001968_abnormal_touch/_nociception	0.72721764
95	MP0005375_adipose_tissue_phenotype	0.72467896
96	MP0005535_abnormal_body_temperature	0.71883969
97	MP0002752_abnormal_somatic_nervous	0.71767164
98	MP0003631_nervous_system_phenotype	0.70217945
99	MP0002066_abnormal_motor_capabilities/c	0.70124393
100	MP0003436_decreased_susceptibility_to	0.69933247

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glycolipid metabolism (HP:0010969)	5.02687532
2	Abnormality of liposaccharide metabolism (HP:0010968)	5.02687532
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	5.02687532
4	Myokymia (HP:0002411)	4.67199945
5	Polyphagia (HP:0002591)	3.85483364
6	Neurofibrillary tangles (HP:0002185)	3.81526061
7	Acute necrotizing encephalopathy (HP:0006965)	3.33741490
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30024138
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.27210429
10	Supranuclear gaze palsy (HP:0000605)	3.23546762
11	Hyperthyroidism (HP:0000836)	3.21891121
12	Axonal loss (HP:0003447)	3.10380531
13	Nuclear cataract (HP:0100018)	2.99542861
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.98488241
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.98488241
16	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.97080517
17	Systemic lupus erythematosus (HP:0002725)	2.96153731
18	Renal Fanconi syndrome (HP:0001994)	2.93687452
19	Prolonged neonatal jaundice (HP:0006579)	2.91696663
20	Cerebral inclusion bodies (HP:0100314)	2.86711014
21	Hyperparathyroidism (HP:0000843)	2.84635804
22	Mutism (HP:0002300)	2.83635773
23	Mitochondrial inheritance (HP:0001427)	2.82052481
24	Agitation (HP:0000713)	2.76946485
25	Increased cerebral lipofuscin (HP:0011813)	2.75038096
26	Dysostosis multiplex (HP:0000943)	2.74399125
27	Acute encephalopathy (HP:0006846)	2.73915372
28	Abnormal number of erythroid precursors (HP:0012131)	2.64892581
29	Broad distal phalanx of finger (HP:0009836)	2.64342011
30	Patent foramen ovale (HP:0001655)	2.58291531
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.55215225
32	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.54521774
33	Progressive macrocephaly (HP:0004481)	2.54226554
34	Vacuolated lymphocytes (HP:0001922)	2.51385358
35	Reticulocytopenia (HP:0001896)	2.50770040
36	Abnormal eating behavior (HP:0100738)	2.45932221
37	Focal dystonia (HP:0004373)	2.42250177
38	Short femoral neck (HP:0100864)	2.40286140
39	Increased muscle lipid content (HP:0009058)	2.39849869
40	Increased intramyocellular lipid droplets (HP:0012240)	2.39009177
41	Retinal atrophy (HP:0001105)	2.38153242
42	Increased CSF lactate (HP:0002490)	2.32153936
43	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.31997752
44	Loss of speech (HP:0002371)	2.31587610
45	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.30038417
46	Mesangial abnormality (HP:0001966)	2.27627624
47	Craniofacial dystonia (HP:0012179)	2.26383527
48	Achilles tendon contracture (HP:0001771)	2.17379248
49	Progressive neurologic deterioration (HP:0002344)	2.17028314
50	Hepatocellular necrosis (HP:0001404)	2.15441656
51	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.13842142
52	Lipid accumulation in hepatocytes (HP:0006561)	2.10935580
53	Microretrognathia (HP:0000308)	2.09689846
54	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.04625666
55	Flat capital femoral epiphysis (HP:0003370)	2.02684680
56	Increased hepatocellular lipid droplets (HP:0006565)	2.01656443
57	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.00609126
58	Abnormality of polysaccharide metabolism (HP:0011012)	2.00609126
59	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.00609126
60	Turricephaly (HP:0000262)	1.98468153
61	Neuronal loss in central nervous system (HP:0002529)	1.97022371
62	Hypercalcemia (HP:0003072)	1.96774071
63	Visual hallucinations (HP:0002367)	1.95123630
64	3-Methylglutaconic aciduria (HP:0003535)	1.94891959
65	Ragged-red muscle fibers (HP:0003200)	1.92137267
66	Respiratory failure (HP:0002878)	1.91448099
67	Spastic tetraparesis (HP:0001285)	1.89009357
68	Hepatic necrosis (HP:0002605)	1.86924196
69	Poor suck (HP:0002033)	1.86796520
70	Abnormality of renal resorption (HP:0011038)	1.86735784
71	Congenital malformation of the right heart (HP:0011723)	1.86110276
72	Double outlet right ventricle (HP:0001719)	1.86110276
73	Dementia (HP:0000726)	1.86051547
74	Diminished motivation (HP:0000745)	1.85932840
75	Disinhibition (HP:0000734)	1.84891229
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.82552048
77	Abnormality of the Achilles tendon (HP:0005109)	1.81430197
78	Irregular vertebral endplates (HP:0003301)	1.81274742
79	Abnormality of the vertebral endplates (HP:0005106)	1.80678467
80	Congenital glaucoma (HP:0001087)	1.80375667
81	Cerebral edema (HP:0002181)	1.79822189
82	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78880003
83	Macrocytic anemia (HP:0001972)	1.76231203
84	Hypercortisolism (HP:0001578)	1.73255870
85	Apathy (HP:0000741)	1.72938865
86	Torticollis (HP:0000473)	1.72905541
87	Increased serum ferritin (HP:0003281)	1.72728954
88	Vertebral compression fractures (HP:0002953)	1.72060459
89	Urinary glycosaminoglycan excretion (HP:0003541)	1.71972757
90	Mucopolysacchariduria (HP:0008155)	1.71972757
91	Thin bony cortex (HP:0002753)	1.70385182
92	Distal upper limb amyotrophy (HP:0007149)	1.70024902
93	Upper limb amyotrophy (HP:0009129)	1.70024902
94	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.69023620
95	Truncus arteriosus (HP:0001660)	1.68666524
96	Dysphonia (HP:0001618)	1.68108113
97	Long toe (HP:0010511)	1.67585870
98	Deep palmar crease (HP:0006191)	1.67510074
99	Purpura (HP:0000979)	1.67374163
100	Athetosis (HP:0002305)	1.67242531

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.47630112
2	IRAK3	4.02618791
3	ARAF	3.86134265
4	MAP3K11	3.46061899
5	PIM2	2.95135204
6	ABL2	2.34390114
7	STK16	2.17969815
8	EPHB2	2.17226454
9	BRAF	2.01696465
10	GRK7	1.99279338
11	DDR2	1.96565441
12	BCKDK	1.92886921
13	TESK1	1.91140851
14	TYRO3	1.90310987
15	LIMK1	1.84338975
16	MOS	1.77960118
17	MAP3K9	1.76447954
18	ICK	1.63889322
19	TAOK2	1.57909963
20	TRIB3	1.56630348
21	TAOK1	1.44280271
22	ERN1	1.44247230
23	DYRK2	1.41120404
24	MARK1	1.31366081
25	CAMK1D	1.25111073
26	DAPK3	1.21393057
27	MUSK	1.19460079
28	RPS6KA2	1.17410956
29	TESK2	1.14784135
30	MAP2K7	1.12653291
31	NTRK3	1.09481174
32	DMPK	1.09368993
33	SIK1	1.03207783
34	PRKD3	1.00591650
35	LRRK2	0.98443929
36	MINK1	0.97974052
37	RIPK1	0.97506124
38	NTRK2	0.92493030
39	WNK4	0.92482118
40	IRAK2	0.92411506
41	DYRK3	0.91409213
42	ILK	0.90944487
43	PAK6	0.89559813
44	CAMKK1	0.88668477
45	CDC42BPA	0.85918341
46	AURKA	0.85220479
47	PRKCG	0.83254095
48	LATS2	0.82232871
49	MARK2	0.81488972
50	IKBKB	0.79788772
51	RPS6KC1	0.79474576
52	RPS6KL1	0.79474576
53	CDK14	0.79341361
54	DYRK1B	0.78517207
55	CAMK2G	0.75937157
56	CDK15	0.74852755
57	MATK	0.74597641
58	PRKCI	0.71895086
59	CDK11A	0.71286273
60	TBK1	0.71045504
61	PKN1	0.70011828
62	ADRBK2	0.68811233
63	CASK	0.68525913
64	RPS6KA6	0.67708889
65	SIK2	0.66140792
66	PINK1	0.65945782
67	NTRK1	0.65154518
68	CDK18	0.64398008
69	TGFBR2	0.63691961
70	CSNK1G2	0.62900941
71	TLK1	0.62566977
72	PHKG1	0.60284418
73	PHKG2	0.60284418
74	PAK1	0.59777648
75	CDK5	0.58910415
76	CAMK1G	0.58337533
77	CSNK1G3	0.58248632
78	MAP3K1	0.56120970
79	CAMKK2	0.55589909
80	MAP3K13	0.52383406
81	CAMK2D	0.50835714
82	EPHA4	0.50556598
83	MAPK4	0.50378784
84	IRAK4	0.50321429
85	DAPK2	0.49562599
86	CHUK	0.48200348
87	PTK2	0.46408683
88	MAP2K6	0.44692294
89	GRK5	0.44608943
90	PRKD2	0.42671656
91	MAP3K3	0.41138959
92	CAMK1	0.40228682
93	UHMK1	0.39751394
94	CAMK2B	0.38571262
95	PRKCZ	0.38515568
96	MAPK15	0.37962823
97	CSK	0.36238176
98	STK11	0.33109854
99	PRKCD	0.33018481
100	AKT2	0.33002165

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.33403371
2	Ribosome_Homo sapiens_hsa03010	4.00099657
3	Parkinsons disease_Homo sapiens_hsa05012	3.29820294
4	Sulfur relay system_Homo sapiens_hsa04122	3.00345061
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.86004019
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.69564076
7	Lysosome_Homo sapiens_hsa04142	2.60321278
8	Alzheimers disease_Homo sapiens_hsa05010	2.59990213
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.52680984
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.39404731
11	Vibrio cholerae infection_Homo sapiens_hsa05110	2.26296050
12	Huntingtons disease_Homo sapiens_hsa05016	2.21315284
13	Other glycan degradation_Homo sapiens_hsa00511	2.17473600
14	Prion diseases_Homo sapiens_hsa05020	2.14079156
15	Folate biosynthesis_Homo sapiens_hsa00790	2.14078871
16	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.07260560
17	Rheumatoid arthritis_Homo sapiens_hsa05323	2.06615741
18	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.93550329
19	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.79388520
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71401957
21	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.68375162
22	Sulfur metabolism_Homo sapiens_hsa00920	1.53740721
23	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.51039842
24	Salmonella infection_Homo sapiens_hsa05132	1.50449427
25	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.49844504
26	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.46744883
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41652471
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39394021
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.29211336
30	Mineral absorption_Homo sapiens_hsa04978	1.28041221
31	Notch signaling pathway_Homo sapiens_hsa04330	1.17916051
32	Galactose metabolism_Homo sapiens_hsa00052	1.16938022
33	Bladder cancer_Homo sapiens_hsa05219	1.16843571
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.12145101
35	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.07132286
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97467766
37	Phagosome_Homo sapiens_hsa04145	0.97212291
38	Pertussis_Homo sapiens_hsa05133	0.95620411
39	Malaria_Homo sapiens_hsa05144	0.94117878
40	Glutathione metabolism_Homo sapiens_hsa00480	0.92253480
41	TNF signaling pathway_Homo sapiens_hsa04668	0.87649939
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.85621698
43	Osteoclast differentiation_Homo sapiens_hsa04380	0.85244959
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84783351
45	VEGF signaling pathway_Homo sapiens_hsa04370	0.83727035
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79637833
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75900774
48	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.71152056
49	Cocaine addiction_Homo sapiens_hsa05030	0.69482295
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.68769521
51	Axon guidance_Homo sapiens_hsa04360	0.68731186
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66461252
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.62658374
54	GABAergic synapse_Homo sapiens_hsa04727	0.61267264
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.60326723
56	Insulin secretion_Homo sapiens_hsa04911	0.57840813
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57439597
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.56735204
59	Morphine addiction_Homo sapiens_hsa05032	0.54996658
60	Tuberculosis_Homo sapiens_hsa05152	0.54950785
61	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.54196210
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51719399
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50812413
64	Fatty acid elongation_Homo sapiens_hsa00062	0.49314693
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.48361823
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46623691
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.46339980
68	Protein export_Homo sapiens_hsa03060	0.45109519
69	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.44563435
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44496559
71	PPAR signaling pathway_Homo sapiens_hsa03320	0.42707816
72	Metabolic pathways_Homo sapiens_hsa01100	0.42563746
73	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.41866526
74	Endocytosis_Homo sapiens_hsa04144	0.41286729
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37659382
76	African trypanosomiasis_Homo sapiens_hsa05143	0.37461619
77	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36342858
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.35802335
79	Nicotine addiction_Homo sapiens_hsa05033	0.34985838
80	Shigellosis_Homo sapiens_hsa05131	0.33415600
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32935443
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32756928
83	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.32077477
84	Peroxisome_Homo sapiens_hsa04146	0.31885980
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31243868
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.29621729
87	Alcoholism_Homo sapiens_hsa05034	0.28443111
88	Chemokine signaling pathway_Homo sapiens_hsa04062	0.26963529
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.26015876
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24808499
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24240958
92	Legionellosis_Homo sapiens_hsa05134	0.24016076
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.23536680
94	Cholinergic synapse_Homo sapiens_hsa04725	0.21953784
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.21400476
96	RNA polymerase_Homo sapiens_hsa03020	0.19728726
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.18384192
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.18375365
99	Apoptosis_Homo sapiens_hsa04210	0.18222261
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.17502350

C1ORF122

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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