

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.71585063 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.40136809 |
| 3 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.21867368 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 5.18001481 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.13075771 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 5.13075771 |
| 7 | protein complex biogenesis (GO:0070271) | 4.92001567 |
| 8 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.67635543 |
| 9 | respiratory electron transport chain (GO:0022904) | 4.60510125 |
| 10 | electron transport chain (GO:0022900) | 4.50229000 |
| 11 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.49723038 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.49723038 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 4.49723038 |
| 14 | respiratory chain complex IV assembly (GO:0008535) | 4.39170929 |
| 15 | viral transcription (GO:0019083) | 4.35718150 |
| 16 | cytochrome complex assembly (GO:0017004) | 4.24540733 |
| 17 | translational termination (GO:0006415) | 4.22346549 |
| 18 | maturation of SSU-rRNA (GO:0030490) | 4.13150135 |
| 19 | cullin deneddylation (GO:0010388) | 4.11570698 |
| 20 | regulation of mitochondrial translation (GO:0070129) | 4.08434721 |
| 21 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.08042887 |
| 22 | cotranslational protein targeting to membrane (GO:0006613) | 4.02894857 |
| 23 | protein targeting to ER (GO:0045047) | 3.97370142 |
| 24 | ribosomal large subunit biogenesis (GO:0042273) | 3.96220073 |
| 25 | protein deneddylation (GO:0000338) | 3.94861275 |
| 26 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.89873097 |
| 27 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.89873097 |
| 28 | oxidative phosphorylation (GO:0006119) | 3.88338889 |
| 29 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.83048260 |
| 30 | protein localization to endoplasmic reticulum (GO:0070972) | 3.79986002 |
| 31 | proteasome assembly (GO:0043248) | 3.75994516 |
| 32 | protein neddylation (GO:0045116) | 3.72594070 |
| 33 | translational elongation (GO:0006414) | 3.71720494 |
| 34 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69998294 |
| 35 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.69275012 |
| 36 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.64396119 |
| 37 | aldehyde catabolic process (GO:0046185) | 3.61855096 |
| 38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.56821651 |
| 39 | protein targeting to mitochondrion (GO:0006626) | 3.56181946 |
| 40 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.44812784 |
| 41 | ribosomal small subunit biogenesis (GO:0042274) | 3.42764681 |
| 42 | translation (GO:0006412) | 3.37076216 |
| 43 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.32683466 |
| 44 | negative regulation of ligase activity (GO:0051352) | 3.32683466 |
| 45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31048959 |
| 46 | establishment of protein localization to mitochondrion (GO:0072655) | 3.29869857 |
| 47 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.25860348 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.25860348 |
| 49 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.25714098 |
| 50 | viral life cycle (GO:0019058) | 3.24396304 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.23554260 |
| 52 | translational initiation (GO:0006413) | 3.22545957 |
| 53 | pattern specification involved in kidney development (GO:0061004) | 3.22018713 |
| 54 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.20205044 |
| 55 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.19466858 |
| 56 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.19447294 |
| 57 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.18691400 |
| 58 | GTP biosynthetic process (GO:0006183) | 3.18071390 |
| 59 | protein localization to mitochondrion (GO:0070585) | 3.14369811 |
| 60 | metallo-sulfur cluster assembly (GO:0031163) | 3.12931288 |
| 61 | iron-sulfur cluster assembly (GO:0016226) | 3.12931288 |
| 62 | ubiquinone biosynthetic process (GO:0006744) | 3.12843493 |
| 63 | protein-cofactor linkage (GO:0018065) | 3.12311983 |
| 64 | mannosylation (GO:0097502) | 3.11096863 |
| 65 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.10734733 |
| 66 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.10734733 |
| 67 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.10734733 |
| 68 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10148611 |
| 69 | cellular protein complex disassembly (GO:0043624) | 3.08299638 |
| 70 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.07482594 |
| 71 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.07482594 |
| 72 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.06665267 |
| 73 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.06664445 |
| 74 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.06509315 |
| 75 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.05517841 |
| 76 | inner mitochondrial membrane organization (GO:0007007) | 3.05125990 |
| 77 | DNA deamination (GO:0045006) | 3.04250228 |
| 78 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.04133313 |
| 79 | cellular component biogenesis (GO:0044085) | 3.03436415 |
| 80 | seminiferous tubule development (GO:0072520) | 3.03419299 |
| 81 | ATP biosynthetic process (GO:0006754) | 3.03062252 |
| 82 | DNA double-strand break processing (GO:0000729) | 3.02642141 |
| 83 | positive regulation of ligase activity (GO:0051351) | 3.02137230 |
| 84 | branched-chain amino acid catabolic process (GO:0009083) | 3.01145796 |
| 85 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.00945104 |
| 86 | hydrogen ion transmembrane transport (GO:1902600) | 2.96366825 |
| 87 | platelet dense granule organization (GO:0060155) | 2.96014003 |
| 88 | pseudouridine synthesis (GO:0001522) | 2.95091410 |
| 89 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.94589676 |
| 90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.94589676 |
| 91 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.93314854 |
| 92 | deoxyribonucleotide catabolic process (GO:0009264) | 2.92983972 |
| 93 | chromatin remodeling at centromere (GO:0031055) | 2.90825346 |
| 94 | regulation of cilium movement (GO:0003352) | 2.90639526 |
| 95 | 7-methylguanosine mRNA capping (GO:0006370) | 2.89742624 |
| 96 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.86522582 |
| 97 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.85047298 |
| 98 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.81856933 |
| 99 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.81856933 |
| 100 | deoxyribose phosphate catabolic process (GO:0046386) | 2.80993206 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.04281492 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.60357137 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.21519945 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.67889233 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.45682270 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.34849296 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.20692146 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.20150118 |
| 9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.98640752 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.88650524 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.77231368 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.71397969 |
| 13 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.64950308 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.63462039 |
| 15 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.63243937 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.47673203 |
| 17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.32100638 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.29761566 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.24689319 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.22345348 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.06895691 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.05436309 |
| 23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.03087747 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.94548016 |
| 25 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.93772171 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.91146266 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.88209994 |
| 28 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.87538107 |
| 29 | VDR_22108803_ChIP-Seq_LS180_Human | 1.85453498 |
| 30 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.85145021 |
| 31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.83595706 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.82038016 |
| 33 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81133088 |
| 34 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.80414302 |
| 35 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.80374014 |
| 36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.66117140 |
| 37 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.60904084 |
| 38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.60854605 |
| 39 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.58344230 |
| 40 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.55461148 |
| 41 | FUS_26573619_Chip-Seq_HEK293_Human | 1.54097314 |
| 42 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.53753805 |
| 43 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.51441558 |
| 44 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.51427152 |
| 45 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.49084461 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.36136750 |
| 47 | EWS_26573619_Chip-Seq_HEK293_Human | 1.35081663 |
| 48 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.31367805 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.28944879 |
| 50 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.26210429 |
| 51 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.23747358 |
| 52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.22032963 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.21405466 |
| 54 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.18736413 |
| 55 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.18017198 |
| 56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17685719 |
| 57 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.15926790 |
| 58 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.15305839 |
| 59 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.11463428 |
| 60 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.10846314 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05247403 |
| 62 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.02021162 |
| 63 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.98261244 |
| 64 | * P300_19829295_ChIP-Seq_ESCs_Human | 0.97829559 |
| 65 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.97596979 |
| 66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.97058812 |
| 67 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.96808401 |
| 68 | AR_20517297_ChIP-Seq_VCAP_Human | 0.95908259 |
| 69 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.94917483 |
| 70 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.94649731 |
| 71 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93869669 |
| 72 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93869669 |
| 73 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.93406830 |
| 74 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.90839244 |
| 75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.90326546 |
| 76 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.90091823 |
| 77 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88659833 |
| 78 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.88385604 |
| 79 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.88385604 |
| 80 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88326840 |
| 81 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.88094240 |
| 82 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.87596153 |
| 83 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.86924398 |
| 84 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.85887133 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85198876 |
| 86 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84558875 |
| 87 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.83457495 |
| 88 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.82705925 |
| 89 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.81055662 |
| 90 | NCOR_22424771_ChIP-Seq_293T_Human | 0.80887240 |
| 91 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80834302 |
| 92 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.80628656 |
| 93 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.80207411 |
| 94 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.79984945 |
| 95 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.79342700 |
| 96 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.79254529 |
| 97 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.78498510 |
| 98 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78231178 |
| 99 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.78209120 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.78016917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.55774414 |
| 2 | MP0008877_abnormal_DNA_methylation | 3.50124928 |
| 3 | MP0008058_abnormal_DNA_repair | 3.21010522 |
| 4 | MP0003011_delayed_dark_adaptation | 2.98103276 |
| 5 | MP0009379_abnormal_foot_pigmentation | 2.69584632 |
| 6 | MP0003186_abnormal_redox_activity | 2.64076073 |
| 7 | MP0002638_abnormal_pupillary_reflex | 2.48494567 |
| 8 | MP0006072_abnormal_retinal_apoptosis | 2.48241827 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.46991155 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.34002856 |
| 11 | MP0003786_premature_aging | 2.28664949 |
| 12 | MP0004147_increased_porphyrin_level | 2.24738223 |
| 13 | MP0001529_abnormal_vocalization | 1.99467573 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 1.94570959 |
| 15 | MP0005551_abnormal_eye_electrophysiolog | 1.93660396 |
| 16 | MP0002102_abnormal_ear_morphology | 1.92184713 |
| 17 | MP0003880_abnormal_central_pattern | 1.90352549 |
| 18 | MP0005253_abnormal_eye_physiology | 1.90039967 |
| 19 | MP0006276_abnormal_autonomic_nervous | 1.89272963 |
| 20 | MP0001984_abnormal_olfaction | 1.84048789 |
| 21 | MP0004142_abnormal_muscle_tone | 1.83074461 |
| 22 | MP0003787_abnormal_imprinting | 1.74705129 |
| 23 | MP0008789_abnormal_olfactory_epithelium | 1.74608546 |
| 24 | MP0008995_early_reproductive_senescence | 1.66705639 |
| 25 | MP0004145_abnormal_muscle_electrophysio | 1.63896268 |
| 26 | MP0001764_abnormal_homeostasis | 1.62416111 |
| 27 | MP0006035_abnormal_mitochondrial_morpho | 1.61293511 |
| 28 | MP0001905_abnormal_dopamine_level | 1.57360531 |
| 29 | MP0010094_abnormal_chromosome_stability | 1.50192636 |
| 30 | MP0003806_abnormal_nucleotide_metabolis | 1.48820379 |
| 31 | MP0002938_white_spotting | 1.48003722 |
| 32 | MP0002736_abnormal_nociception_after | 1.45344994 |
| 33 | MP0000372_irregular_coat_pigmentation | 1.43237986 |
| 34 | MP0001968_abnormal_touch/_nociception | 1.41586975 |
| 35 | MP0010386_abnormal_urinary_bladder | 1.40923346 |
| 36 | MP0004215_abnormal_myocardial_fiber | 1.32268886 |
| 37 | MP0003718_maternal_effect | 1.28883790 |
| 38 | MP0005646_abnormal_pituitary_gland | 1.28370933 |
| 39 | MP0000631_abnormal_neuroendocrine_gland | 1.26966086 |
| 40 | MP0001542_abnormal_bone_strength | 1.26704320 |
| 41 | MP0004957_abnormal_blastocyst_morpholog | 1.26252701 |
| 42 | MP0003121_genomic_imprinting | 1.13334788 |
| 43 | MP0003646_muscle_fatigue | 1.12567337 |
| 44 | MP0005670_abnormal_white_adipose | 1.11904723 |
| 45 | MP0008932_abnormal_embryonic_tissue | 1.11781020 |
| 46 | MP0002876_abnormal_thyroid_physiology | 1.09468640 |
| 47 | MP0001661_extended_life_span | 1.07204502 |
| 48 | MP0000749_muscle_degeneration | 1.06179752 |
| 49 | MP0002210_abnormal_sex_determination | 1.05640799 |
| 50 | MP0000639_abnormal_adrenal_gland | 1.04930504 |
| 51 | MP0009384_cardiac_valve_regurgitation | 1.00223590 |
| 52 | MP0000516_abnormal_urinary_system | 0.99986484 |
| 53 | MP0005367_renal/urinary_system_phenotyp | 0.99986484 |
| 54 | MP0009697_abnormal_copulation | 0.98913775 |
| 55 | MP0002234_abnormal_pharynx_morphology | 0.98409054 |
| 56 | MP0009046_muscle_twitch | 0.98075054 |
| 57 | MP0000653_abnormal_sex_gland | 0.97680091 |
| 58 | MP0000049_abnormal_middle_ear | 0.97048274 |
| 59 | MP0005379_endocrine/exocrine_gland_phen | 0.96194677 |
| 60 | MP0009745_abnormal_behavioral_response | 0.95420167 |
| 61 | MP0005499_abnormal_olfactory_system | 0.93676127 |
| 62 | MP0005394_taste/olfaction_phenotype | 0.93676127 |
| 63 | MP0002653_abnormal_ependyma_morphology | 0.93343528 |
| 64 | MP0001486_abnormal_startle_reflex | 0.92890910 |
| 65 | MP0005195_abnormal_posterior_eye | 0.91778786 |
| 66 | MP0004133_heterotaxia | 0.91548002 |
| 67 | MP0001929_abnormal_gametogenesis | 0.91066098 |
| 68 | MP0001145_abnormal_male_reproductive | 0.90434663 |
| 69 | MP0003136_yellow_coat_color | 0.90051983 |
| 70 | MP0005391_vision/eye_phenotype | 0.89745700 |
| 71 | MP0005389_reproductive_system_phenotype | 0.89387041 |
| 72 | MP0008875_abnormal_xenobiotic_pharmacok | 0.88777361 |
| 73 | MP0003938_abnormal_ear_development | 0.86884496 |
| 74 | MP0008775_abnormal_heart_ventricle | 0.86821814 |
| 75 | MP0001293_anophthalmia | 0.86358885 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.83334124 |
| 77 | MP0003123_paternal_imprinting | 0.82660699 |
| 78 | MP0003693_abnormal_embryo_hatching | 0.82164697 |
| 79 | MP0005332_abnormal_amino_acid | 0.80903043 |
| 80 | MP0008872_abnormal_physiological_respon | 0.80696512 |
| 81 | MP0003137_abnormal_impulse_conducting | 0.80299188 |
| 82 | MP0001986_abnormal_taste_sensitivity | 0.80158026 |
| 83 | MP0010030_abnormal_orbit_morphology | 0.79737943 |
| 84 | MP0000013_abnormal_adipose_tissue | 0.79608722 |
| 85 | MP0003111_abnormal_nucleus_morphology | 0.78939048 |
| 86 | MP0003119_abnormal_digestive_system | 0.76943941 |
| 87 | MP0003698_abnormal_male_reproductive | 0.76926123 |
| 88 | MP0002160_abnormal_reproductive_system | 0.76472931 |
| 89 | MP0002272_abnormal_nervous_system | 0.75840448 |
| 90 | MP0001485_abnormal_pinna_reflex | 0.75830152 |
| 91 | MP0002557_abnormal_social/conspecific_i | 0.74552991 |
| 92 | MP0008007_abnormal_cellular_replicative | 0.74059127 |
| 93 | MP0003077_abnormal_cell_cycle | 0.73545934 |
| 94 | MP0000358_abnormal_cell_content/ | 0.72810516 |
| 95 | MP0000026_abnormal_inner_ear | 0.71214181 |
| 96 | MP0002752_abnormal_somatic_nervous | 0.70577612 |
| 97 | MP0001119_abnormal_female_reproductive | 0.70466984 |
| 98 | MP0001963_abnormal_hearing_physiology | 0.70397222 |
| 99 | MP0005410_abnormal_fertilization | 0.69618078 |
| 100 | MP0002163_abnormal_gland_morphology | 0.69145981 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.30958802 |
| 2 | Mitochondrial inheritance (HP:0001427) | 5.30796033 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.92651045 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.91485179 |
| 5 | Acute encephalopathy (HP:0006846) | 4.69727248 |
| 6 | Increased CSF lactate (HP:0002490) | 4.62635573 |
| 7 | Hepatic necrosis (HP:0002605) | 4.54341265 |
| 8 | Progressive macrocephaly (HP:0004481) | 4.51543285 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.15039535 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 4.06824165 |
| 11 | 3-Methylglutaconic aciduria (HP:0003535) | 3.52854514 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.50657512 |
| 13 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.50149978 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.50149978 |
| 15 | Increased intramyocellular lipid droplets (HP:0012240) | 3.38408808 |
| 16 | Cerebral edema (HP:0002181) | 3.32512333 |
| 17 | Abnormal number of erythroid precursors (HP:0012131) | 3.24887319 |
| 18 | Molar tooth sign on MRI (HP:0002419) | 3.15127079 |
| 19 | Abnormality of midbrain morphology (HP:0002418) | 3.15127079 |
| 20 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.11967885 |
| 21 | Lactic acidosis (HP:0003128) | 3.09760135 |
| 22 | Increased serum lactate (HP:0002151) | 3.07084869 |
| 23 | Medial flaring of the eyebrow (HP:0010747) | 3.06292473 |
| 24 | Increased muscle lipid content (HP:0009058) | 3.04787812 |
| 25 | Respiratory failure (HP:0002878) | 2.97211436 |
| 26 | True hermaphroditism (HP:0010459) | 2.96335295 |
| 27 | Colon cancer (HP:0003003) | 2.94238369 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.83587120 |
| 29 | Pancreatic fibrosis (HP:0100732) | 2.71586199 |
| 30 | Exercise intolerance (HP:0003546) | 2.67318840 |
| 31 | Macrocytic anemia (HP:0001972) | 2.65482378 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.58698717 |
| 33 | Exertional dyspnea (HP:0002875) | 2.54921542 |
| 34 | CNS demyelination (HP:0007305) | 2.51234408 |
| 35 | Congenital primary aphakia (HP:0007707) | 2.45980358 |
| 36 | Pancreatic cysts (HP:0001737) | 2.45975460 |
| 37 | Optic disc pallor (HP:0000543) | 2.44882692 |
| 38 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.40910855 |
| 39 | Abnormality of the labia minora (HP:0012880) | 2.39103799 |
| 40 | Reticulocytopenia (HP:0001896) | 2.37562916 |
| 41 | Lethargy (HP:0001254) | 2.35480828 |
| 42 | Gait imbalance (HP:0002141) | 2.32665584 |
| 43 | Nephronophthisis (HP:0000090) | 2.32055617 |
| 44 | Type 2 muscle fiber atrophy (HP:0003554) | 2.31335155 |
| 45 | Aplastic anemia (HP:0001915) | 2.28063194 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.24120641 |
| 47 | Nephrogenic diabetes insipidus (HP:0009806) | 2.19741212 |
| 48 | Hyperglycinemia (HP:0002154) | 2.18676204 |
| 49 | Abnormality of renal resorption (HP:0011038) | 2.17170928 |
| 50 | Respiratory difficulties (HP:0002880) | 2.16385518 |
| 51 | Leukodystrophy (HP:0002415) | 2.16042611 |
| 52 | Glycosuria (HP:0003076) | 2.09769768 |
| 53 | Abnormality of urine glucose concentration (HP:0011016) | 2.09769768 |
| 54 | Congenital stationary night blindness (HP:0007642) | 2.08339699 |
| 55 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.05589529 |
| 56 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.05589529 |
| 57 | Abnormal protein glycosylation (HP:0012346) | 2.05589529 |
| 58 | Abnormal glycosylation (HP:0012345) | 2.05589529 |
| 59 | Opisthotonus (HP:0002179) | 2.04713784 |
| 60 | Muscle fiber atrophy (HP:0100295) | 2.02015515 |
| 61 | X-linked dominant inheritance (HP:0001423) | 2.01896569 |
| 62 | Emotional lability (HP:0000712) | 2.01765622 |
| 63 | Cerebral hypomyelination (HP:0006808) | 1.99188865 |
| 64 | Methylmalonic aciduria (HP:0012120) | 1.98501174 |
| 65 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.97517789 |
| 66 | Dicarboxylic aciduria (HP:0003215) | 1.91979120 |
| 67 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.91979120 |
| 68 | Retinal dysplasia (HP:0007973) | 1.91491468 |
| 69 | Rib fusion (HP:0000902) | 1.90990701 |
| 70 | Male pseudohermaphroditism (HP:0000037) | 1.90927527 |
| 71 | Hyperglycinuria (HP:0003108) | 1.89074606 |
| 72 | Septo-optic dysplasia (HP:0100842) | 1.87785583 |
| 73 | Vaginal atresia (HP:0000148) | 1.84012959 |
| 74 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.82797978 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 1.82675261 |
| 76 | Hyperalaninemia (HP:0003348) | 1.82675261 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.82675261 |
| 78 | Genital tract atresia (HP:0001827) | 1.81613273 |
| 79 | Abnormality of the anterior horn cell (HP:0006802) | 1.81190918 |
| 80 | Degeneration of anterior horn cells (HP:0002398) | 1.81190918 |
| 81 | Hyperphosphaturia (HP:0003109) | 1.80437789 |
| 82 | Type II lissencephaly (HP:0007260) | 1.77961175 |
| 83 | Abnormality of cochlea (HP:0000375) | 1.77920234 |
| 84 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.77087533 |
| 85 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.77087533 |
| 86 | Median cleft lip (HP:0000161) | 1.76984136 |
| 87 | Short tibia (HP:0005736) | 1.76283117 |
| 88 | Abnormality of glycine metabolism (HP:0010895) | 1.73146746 |
| 89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.73146746 |
| 90 | Absent septum pellucidum (HP:0001331) | 1.71787547 |
| 91 | Abolished electroretinogram (ERG) (HP:0000550) | 1.69966032 |
| 92 | Constricted visual fields (HP:0001133) | 1.69636282 |
| 93 | Cerebral palsy (HP:0100021) | 1.69040955 |
| 94 | Sclerocornea (HP:0000647) | 1.67682856 |
| 95 | Increased serum pyruvate (HP:0003542) | 1.66297848 |
| 96 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.66204983 |
| 97 | Growth hormone deficiency (HP:0000824) | 1.64217077 |
| 98 | Adrenal hypoplasia (HP:0000835) | 1.63272760 |
| 99 | Abnormality of serum amino acid levels (HP:0003112) | 1.63052286 |
| 100 | Stenosis of the external auditory canal (HP:0000402) | 1.61989151 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.68519766 |
| 2 | STK16 | 3.31080102 |
| 3 | MAP4K2 | 2.77992299 |
| 4 | BCKDK | 2.71639014 |
| 5 | ZAK | 2.48975377 |
| 6 | BMPR1B | 2.37820163 |
| 7 | BUB1 | 2.31781898 |
| 8 | NUAK1 | 2.31331190 |
| 9 | EIF2AK3 | 2.28937314 |
| 10 | CDK19 | 2.06548683 |
| 11 | FRK | 2.03509233 |
| 12 | PLK4 | 1.98124992 |
| 13 | VRK1 | 1.94932358 |
| 14 | NME1 | 1.86722177 |
| 15 | STK38L | 1.85951830 |
| 16 | EIF2AK1 | 1.68280920 |
| 17 | CDC7 | 1.64313728 |
| 18 | INSRR | 1.60875165 |
| 19 | PIM2 | 1.51725177 |
| 20 | WNK3 | 1.47646589 |
| 21 | CSNK1G3 | 1.45866926 |
| 22 | PDK2 | 1.45081930 |
| 23 | PINK1 | 1.44510935 |
| 24 | BRSK2 | 1.37399441 |
| 25 | TLK1 | 1.34776126 |
| 26 | CSNK1G1 | 1.34409223 |
| 27 | ADRBK2 | 1.26865747 |
| 28 | CSNK1G2 | 1.25754120 |
| 29 | PLK3 | 1.25669756 |
| 30 | SRPK1 | 1.25022877 |
| 31 | OBSCN | 1.19973234 |
| 32 | NEK1 | 1.17513193 |
| 33 | CSNK1A1L | 1.16495240 |
| 34 | KDR | 1.14641846 |
| 35 | CDK8 | 1.14049977 |
| 36 | DYRK2 | 1.13819010 |
| 37 | MST4 | 1.12060170 |
| 38 | GRK1 | 1.11608375 |
| 39 | PHKG1 | 1.09249511 |
| 40 | PHKG2 | 1.09249511 |
| 41 | MAP3K4 | 1.08652946 |
| 42 | PLK1 | 1.03686669 |
| 43 | PLK2 | 1.03480221 |
| 44 | TNIK | 0.97482365 |
| 45 | LIMK1 | 0.93419042 |
| 46 | MAP2K7 | 0.91308532 |
| 47 | MYLK | 0.86843270 |
| 48 | TIE1 | 0.85578922 |
| 49 | PBK | 0.83303753 |
| 50 | NME2 | 0.82570706 |
| 51 | TAOK3 | 0.82304508 |
| 52 | PRKD3 | 0.80950464 |
| 53 | MAPK13 | 0.76829747 |
| 54 | OXSR1 | 0.76338776 |
| 55 | EIF2AK2 | 0.74006789 |
| 56 | MUSK | 0.71677780 |
| 57 | BRSK1 | 0.67672518 |
| 58 | DYRK3 | 0.67432313 |
| 59 | AURKB | 0.66567055 |
| 60 | MKNK1 | 0.66009723 |
| 61 | PRKCG | 0.65879251 |
| 62 | TGFBR1 | 0.65548411 |
| 63 | DAPK3 | 0.65291750 |
| 64 | TAF1 | 0.64730643 |
| 65 | PIK3CG | 0.63844904 |
| 66 | TNK2 | 0.63332165 |
| 67 | CSNK2A1 | 0.63133214 |
| 68 | GRK5 | 0.62750218 |
| 69 | ILK | 0.61961065 |
| 70 | STK4 | 0.61890343 |
| 71 | EPHA4 | 0.60515805 |
| 72 | DAPK1 | 0.60435502 |
| 73 | ERBB3 | 0.60191369 |
| 74 | CSNK2A2 | 0.59155556 |
| 75 | ABL2 | 0.57139708 |
| 76 | TRIM28 | 0.56905300 |
| 77 | BCR | 0.54976850 |
| 78 | ATR | 0.54497589 |
| 79 | TEC | 0.53844306 |
| 80 | TTK | 0.52244763 |
| 81 | AURKA | 0.52049798 |
| 82 | TESK1 | 0.50323558 |
| 83 | LRRK2 | 0.49956533 |
| 84 | CAMK2D | 0.49640884 |
| 85 | CASK | 0.49446238 |
| 86 | TESK2 | 0.48410024 |
| 87 | RPS6KA5 | 0.47129702 |
| 88 | KIT | 0.45872016 |
| 89 | MAPKAPK3 | 0.45617646 |
| 90 | MINK1 | 0.44781190 |
| 91 | PRKCE | 0.43332868 |
| 92 | CHEK2 | 0.43228400 |
| 93 | CAMK2A | 0.43068570 |
| 94 | ATM | 0.42899230 |
| 95 | PRKACA | 0.42675971 |
| 96 | ADRBK1 | 0.40063163 |
| 97 | PRKG1 | 0.39593600 |
| 98 | FGFR2 | 0.39021850 |
| 99 | CCNB1 | 0.37673525 |
| 100 | PKN1 | 0.36529609 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.16262231 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.13701684 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.11399867 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.57728663 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.67833753 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.65929792 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.49933788 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.29209733 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.24442282 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.16798096 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 2.09262018 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.95249780 |
| 13 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.94282641 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.89568165 |
| 15 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.83707057 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.78429903 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.76251984 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.71235257 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.71036844 |
| 20 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.70111745 |
| 21 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.69650389 |
| 22 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.65529828 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.61896318 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.60021204 |
| 25 | Basal transcription factors_Homo sapiens_hsa03022 | 1.59142868 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.56433115 |
| 27 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.55804187 |
| 28 | Sulfur relay system_Homo sapiens_hsa04122 | 1.50380533 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.47071770 |
| 30 | RNA degradation_Homo sapiens_hsa03018 | 1.41674099 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.38332523 |
| 32 | Peroxisome_Homo sapiens_hsa04146 | 1.30923974 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.30144147 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.24116728 |
| 35 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.24018699 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.22998257 |
| 37 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.21878966 |
| 38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.16502943 |
| 39 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.14666118 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.14007972 |
| 41 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.10062114 |
| 42 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.06063629 |
| 43 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.98369393 |
| 44 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.93828951 |
| 45 | RNA transport_Homo sapiens_hsa03013 | 0.93654383 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.92713902 |
| 47 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.92541375 |
| 48 | Metabolic pathways_Homo sapiens_hsa01100 | 0.92408925 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.91025564 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.90352942 |
| 51 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83428125 |
| 52 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82407404 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 0.78891756 |
| 54 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.77178004 |
| 55 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.76097980 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75192744 |
| 57 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.73280235 |
| 58 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.72968641 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.72202873 |
| 60 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.71630068 |
| 61 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70911798 |
| 62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65868078 |
| 63 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.64992172 |
| 64 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62113227 |
| 65 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.55966409 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55791875 |
| 67 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.55753712 |
| 68 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.53275764 |
| 69 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.52152959 |
| 70 | Nicotine addiction_Homo sapiens_hsa05033 | 0.52007511 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.51889169 |
| 72 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.51071238 |
| 73 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49222586 |
| 74 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46293575 |
| 75 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.45707670 |
| 76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45443946 |
| 77 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44722907 |
| 78 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40809103 |
| 79 | Cell cycle_Homo sapiens_hsa04110 | 0.40487528 |
| 80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.39976323 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37083227 |
| 82 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.36976093 |
| 83 | Circadian rhythm_Homo sapiens_hsa04710 | 0.36798058 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.35412752 |
| 85 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.34812420 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34000455 |
| 87 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.32605978 |
| 88 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.32082395 |
| 89 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31991197 |
| 90 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.31911378 |
| 91 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30603505 |
| 92 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.29825339 |
| 93 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.24357559 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.23670182 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.22990676 |
| 96 | Morphine addiction_Homo sapiens_hsa05032 | 0.21088721 |
| 97 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.19471053 |
| 98 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.19444539 |
| 99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.17869081 |
| 100 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.17278532 |

