C1ORF123

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.71585063
2chaperone-mediated protein transport (GO:0072321)5.40136809
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.21867368
4ribosomal small subunit assembly (GO:0000028)5.18001481
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13075771
6ATP synthesis coupled proton transport (GO:0015986)5.13075771
7protein complex biogenesis (GO:0070271)4.92001567
8mitochondrial respiratory chain complex assembly (GO:0033108)4.67635543
9respiratory electron transport chain (GO:0022904)4.60510125
10electron transport chain (GO:0022900)4.50229000
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49723038
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.49723038
13NADH dehydrogenase complex assembly (GO:0010257)4.49723038
14respiratory chain complex IV assembly (GO:0008535)4.39170929
15viral transcription (GO:0019083)4.35718150
16cytochrome complex assembly (GO:0017004)4.24540733
17translational termination (GO:0006415)4.22346549
18maturation of SSU-rRNA (GO:0030490)4.13150135
19cullin deneddylation (GO:0010388)4.11570698
20regulation of mitochondrial translation (GO:0070129)4.08434721
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08042887
22cotranslational protein targeting to membrane (GO:0006613)4.02894857
23protein targeting to ER (GO:0045047)3.97370142
24ribosomal large subunit biogenesis (GO:0042273)3.96220073
25protein deneddylation (GO:0000338)3.94861275
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.89873097
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.89873097
28oxidative phosphorylation (GO:0006119)3.88338889
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.83048260
30protein localization to endoplasmic reticulum (GO:0070972)3.79986002
31proteasome assembly (GO:0043248)3.75994516
32protein neddylation (GO:0045116)3.72594070
33translational elongation (GO:0006414)3.71720494
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69998294
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69275012
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.64396119
37aldehyde catabolic process (GO:0046185)3.61855096
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56821651
39protein targeting to mitochondrion (GO:0006626)3.56181946
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.44812784
41ribosomal small subunit biogenesis (GO:0042274)3.42764681
42translation (GO:0006412)3.37076216
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32683466
44negative regulation of ligase activity (GO:0051352)3.32683466
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31048959
46establishment of protein localization to mitochondrion (GO:0072655)3.29869857
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.25860348
48termination of RNA polymerase III transcription (GO:0006386)3.25860348
49water-soluble vitamin biosynthetic process (GO:0042364)3.25714098
50viral life cycle (GO:0019058)3.24396304
51regulation of cellular amino acid metabolic process (GO:0006521)3.23554260
52translational initiation (GO:0006413)3.22545957
53pattern specification involved in kidney development (GO:0061004)3.22018713
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20205044
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19466858
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19447294
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18691400
58GTP biosynthetic process (GO:0006183)3.18071390
59protein localization to mitochondrion (GO:0070585)3.14369811
60metallo-sulfur cluster assembly (GO:0031163)3.12931288
61iron-sulfur cluster assembly (GO:0016226)3.12931288
62ubiquinone biosynthetic process (GO:0006744)3.12843493
63protein-cofactor linkage (GO:0018065)3.12311983
64mannosylation (GO:0097502)3.11096863
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10734733
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10734733
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10734733
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10148611
69cellular protein complex disassembly (GO:0043624)3.08299638
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07482594
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07482594
72purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06665267
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.06664445
74pyrimidine nucleotide catabolic process (GO:0006244)3.06509315
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05517841
76inner mitochondrial membrane organization (GO:0007007)3.05125990
77DNA deamination (GO:0045006)3.04250228
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04133313
79cellular component biogenesis (GO:0044085)3.03436415
80seminiferous tubule development (GO:0072520)3.03419299
81ATP biosynthetic process (GO:0006754)3.03062252
82DNA double-strand break processing (GO:0000729)3.02642141
83positive regulation of ligase activity (GO:0051351)3.02137230
84branched-chain amino acid catabolic process (GO:0009083)3.01145796
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00945104
86hydrogen ion transmembrane transport (GO:1902600)2.96366825
87platelet dense granule organization (GO:0060155)2.96014003
88pseudouridine synthesis (GO:0001522)2.95091410
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94589676
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.94589676
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.93314854
92deoxyribonucleotide catabolic process (GO:0009264)2.92983972
93chromatin remodeling at centromere (GO:0031055)2.90825346
94regulation of cilium movement (GO:0003352)2.90639526
957-methylguanosine mRNA capping (GO:0006370)2.89742624
96DNA catabolic process, exonucleolytic (GO:0000738)2.86522582
97preassembly of GPI anchor in ER membrane (GO:0016254)2.85047298
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81856933
99regulation of mitotic spindle checkpoint (GO:1903504)2.81856933
100deoxyribose phosphate catabolic process (GO:0046386)2.80993206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.04281492
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.60357137
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.21519945
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67889233
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45682270
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34849296
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20692146
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.20150118
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98640752
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88650524
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.77231368
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71397969
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.64950308
14VDR_23849224_ChIP-Seq_CD4+_Human2.63462039
15* ELK1_19687146_ChIP-ChIP_HELA_Human2.63243937
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47673203
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32100638
18FOXP3_21729870_ChIP-Seq_TREG_Human2.29761566
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24689319
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22345348
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06895691
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05436309
23ZNF274_21170338_ChIP-Seq_K562_Hela2.03087747
24IGF1R_20145208_ChIP-Seq_DFB_Human1.94548016
25* GABP_19822575_ChIP-Seq_HepG2_Human1.93772171
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91146266
27TTF2_22483619_ChIP-Seq_HELA_Human1.88209994
28MYC_18940864_ChIP-ChIP_HL60_Human1.87538107
29VDR_22108803_ChIP-Seq_LS180_Human1.85453498
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85145021
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83595706
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82038016
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81133088
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80414302
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80374014
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.66117140
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60904084
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60854605
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.58344230
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.55461148
41FUS_26573619_Chip-Seq_HEK293_Human1.54097314
42XRN2_22483619_ChIP-Seq_HELA_Human1.53753805
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51441558
44DCP1A_22483619_ChIP-Seq_HELA_Human1.51427152
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49084461
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36136750
47EWS_26573619_Chip-Seq_HEK293_Human1.35081663
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31367805
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28944879
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26210429
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23747358
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22032963
53TP53_22573176_ChIP-Seq_HFKS_Human1.21405466
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18736413
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18017198
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17685719
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15926790
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15305839
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11463428
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.10846314
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05247403
62IRF1_19129219_ChIP-ChIP_H3396_Human1.02021162
63EZH2_22144423_ChIP-Seq_EOC_Human0.98261244
64* P300_19829295_ChIP-Seq_ESCs_Human0.97829559
65POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97596979
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97058812
67ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96808401
68AR_20517297_ChIP-Seq_VCAP_Human0.95908259
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94917483
70SOX2_16153702_ChIP-ChIP_HESCs_Human0.94649731
71NANOG_19829295_ChIP-Seq_ESCs_Human0.93869669
72SOX2_19829295_ChIP-Seq_ESCs_Human0.93869669
73CIITA_25753668_ChIP-Seq_RAJI_Human0.93406830
74CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90839244
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90326546
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90091823
77NOTCH1_21737748_ChIP-Seq_TLL_Human0.88659833
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88385604
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.88385604
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88326840
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88094240
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.87596153
83KDM5A_27292631_Chip-Seq_BREAST_Human0.86924398
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85887133
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85198876
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84558875
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.83457495
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82705925
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81055662
90NCOR_22424771_ChIP-Seq_293T_Human0.80887240
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80834302
92HTT_18923047_ChIP-ChIP_STHdh_Human0.80628656
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.80207411
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79984945
95E2F7_22180533_ChIP-Seq_HELA_Human0.79342700
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79254529
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78498510
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78231178
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.78209120
100CBP_20019798_ChIP-Seq_JUKART_Human0.78016917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.55774414
2MP0008877_abnormal_DNA_methylation3.50124928
3MP0008058_abnormal_DNA_repair3.21010522
4MP0003011_delayed_dark_adaptation2.98103276
5MP0009379_abnormal_foot_pigmentation2.69584632
6MP0003186_abnormal_redox_activity2.64076073
7MP0002638_abnormal_pupillary_reflex2.48494567
8MP0006072_abnormal_retinal_apoptosis2.48241827
9MP0005084_abnormal_gallbladder_morpholo2.46991155
10MP0006036_abnormal_mitochondrial_physio2.34002856
11MP0003786_premature_aging2.28664949
12MP0004147_increased_porphyrin_level2.24738223
13MP0001529_abnormal_vocalization1.99467573
14MP0002837_dystrophic_cardiac_calcinosis1.94570959
15MP0005551_abnormal_eye_electrophysiolog1.93660396
16MP0002102_abnormal_ear_morphology1.92184713
17MP0003880_abnormal_central_pattern1.90352549
18MP0005253_abnormal_eye_physiology1.90039967
19MP0006276_abnormal_autonomic_nervous1.89272963
20MP0001984_abnormal_olfaction1.84048789
21MP0004142_abnormal_muscle_tone1.83074461
22MP0003787_abnormal_imprinting1.74705129
23MP0008789_abnormal_olfactory_epithelium1.74608546
24MP0008995_early_reproductive_senescence1.66705639
25MP0004145_abnormal_muscle_electrophysio1.63896268
26MP0001764_abnormal_homeostasis1.62416111
27MP0006035_abnormal_mitochondrial_morpho1.61293511
28MP0001905_abnormal_dopamine_level1.57360531
29MP0010094_abnormal_chromosome_stability1.50192636
30MP0003806_abnormal_nucleotide_metabolis1.48820379
31MP0002938_white_spotting1.48003722
32MP0002736_abnormal_nociception_after1.45344994
33MP0000372_irregular_coat_pigmentation1.43237986
34MP0001968_abnormal_touch/_nociception1.41586975
35MP0010386_abnormal_urinary_bladder1.40923346
36MP0004215_abnormal_myocardial_fiber1.32268886
37MP0003718_maternal_effect1.28883790
38MP0005646_abnormal_pituitary_gland1.28370933
39MP0000631_abnormal_neuroendocrine_gland1.26966086
40MP0001542_abnormal_bone_strength1.26704320
41MP0004957_abnormal_blastocyst_morpholog1.26252701
42MP0003121_genomic_imprinting1.13334788
43MP0003646_muscle_fatigue1.12567337
44MP0005670_abnormal_white_adipose1.11904723
45MP0008932_abnormal_embryonic_tissue1.11781020
46MP0002876_abnormal_thyroid_physiology1.09468640
47MP0001661_extended_life_span1.07204502
48MP0000749_muscle_degeneration1.06179752
49MP0002210_abnormal_sex_determination1.05640799
50MP0000639_abnormal_adrenal_gland1.04930504
51MP0009384_cardiac_valve_regurgitation1.00223590
52MP0000516_abnormal_urinary_system0.99986484
53MP0005367_renal/urinary_system_phenotyp0.99986484
54MP0009697_abnormal_copulation0.98913775
55MP0002234_abnormal_pharynx_morphology0.98409054
56MP0009046_muscle_twitch0.98075054
57MP0000653_abnormal_sex_gland0.97680091
58MP0000049_abnormal_middle_ear0.97048274
59MP0005379_endocrine/exocrine_gland_phen0.96194677
60MP0009745_abnormal_behavioral_response0.95420167
61MP0005499_abnormal_olfactory_system0.93676127
62MP0005394_taste/olfaction_phenotype0.93676127
63MP0002653_abnormal_ependyma_morphology0.93343528
64MP0001486_abnormal_startle_reflex0.92890910
65MP0005195_abnormal_posterior_eye0.91778786
66MP0004133_heterotaxia0.91548002
67MP0001929_abnormal_gametogenesis0.91066098
68MP0001145_abnormal_male_reproductive0.90434663
69MP0003136_yellow_coat_color0.90051983
70MP0005391_vision/eye_phenotype0.89745700
71MP0005389_reproductive_system_phenotype0.89387041
72MP0008875_abnormal_xenobiotic_pharmacok0.88777361
73MP0003938_abnormal_ear_development0.86884496
74MP0008775_abnormal_heart_ventricle0.86821814
75MP0001293_anophthalmia0.86358885
76MP0003567_abnormal_fetal_cardiomyocyte0.83334124
77MP0003123_paternal_imprinting0.82660699
78MP0003693_abnormal_embryo_hatching0.82164697
79MP0005332_abnormal_amino_acid0.80903043
80MP0008872_abnormal_physiological_respon0.80696512
81MP0003137_abnormal_impulse_conducting0.80299188
82MP0001986_abnormal_taste_sensitivity0.80158026
83MP0010030_abnormal_orbit_morphology0.79737943
84MP0000013_abnormal_adipose_tissue0.79608722
85MP0003111_abnormal_nucleus_morphology0.78939048
86MP0003119_abnormal_digestive_system0.76943941
87MP0003698_abnormal_male_reproductive0.76926123
88MP0002160_abnormal_reproductive_system0.76472931
89MP0002272_abnormal_nervous_system0.75840448
90MP0001485_abnormal_pinna_reflex0.75830152
91MP0002557_abnormal_social/conspecific_i0.74552991
92MP0008007_abnormal_cellular_replicative0.74059127
93MP0003077_abnormal_cell_cycle0.73545934
94MP0000358_abnormal_cell_content/0.72810516
95MP0000026_abnormal_inner_ear0.71214181
96MP0002752_abnormal_somatic_nervous0.70577612
97MP0001119_abnormal_female_reproductive0.70466984
98MP0001963_abnormal_hearing_physiology0.70397222
99MP0005410_abnormal_fertilization0.69618078
100MP0002163_abnormal_gland_morphology0.69145981

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.30958802
2Mitochondrial inheritance (HP:0001427)5.30796033
3Hepatocellular necrosis (HP:0001404)4.92651045
4Abnormal mitochondria in muscle tissue (HP:0008316)4.91485179
5Acute encephalopathy (HP:0006846)4.69727248
6Increased CSF lactate (HP:0002490)4.62635573
7Hepatic necrosis (HP:0002605)4.54341265
8Progressive macrocephaly (HP:0004481)4.51543285
9Increased hepatocellular lipid droplets (HP:0006565)4.15039535
10Lipid accumulation in hepatocytes (HP:0006561)4.06824165
113-Methylglutaconic aciduria (HP:0003535)3.52854514
12Renal Fanconi syndrome (HP:0001994)3.50657512
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50149978
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50149978
15Increased intramyocellular lipid droplets (HP:0012240)3.38408808
16Cerebral edema (HP:0002181)3.32512333
17Abnormal number of erythroid precursors (HP:0012131)3.24887319
18Molar tooth sign on MRI (HP:0002419)3.15127079
19Abnormality of midbrain morphology (HP:0002418)3.15127079
20Abnormality of cells of the erythroid lineage (HP:0012130)3.11967885
21Lactic acidosis (HP:0003128)3.09760135
22Increased serum lactate (HP:0002151)3.07084869
23Medial flaring of the eyebrow (HP:0010747)3.06292473
24Increased muscle lipid content (HP:0009058)3.04787812
25Respiratory failure (HP:0002878)2.97211436
26True hermaphroditism (HP:0010459)2.96335295
27Colon cancer (HP:0003003)2.94238369
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83587120
29Pancreatic fibrosis (HP:0100732)2.71586199
30Exercise intolerance (HP:0003546)2.67318840
31Macrocytic anemia (HP:0001972)2.65482378
32Type I transferrin isoform profile (HP:0003642)2.58698717
33Exertional dyspnea (HP:0002875)2.54921542
34CNS demyelination (HP:0007305)2.51234408
35Congenital primary aphakia (HP:0007707)2.45980358
36Pancreatic cysts (HP:0001737)2.45975460
37Optic disc pallor (HP:0000543)2.44882692
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40910855
39Abnormality of the labia minora (HP:0012880)2.39103799
40Reticulocytopenia (HP:0001896)2.37562916
41Lethargy (HP:0001254)2.35480828
42Gait imbalance (HP:0002141)2.32665584
43Nephronophthisis (HP:0000090)2.32055617
44Type 2 muscle fiber atrophy (HP:0003554)2.31335155
45Aplastic anemia (HP:0001915)2.28063194
46Methylmalonic acidemia (HP:0002912)2.24120641
47Nephrogenic diabetes insipidus (HP:0009806)2.19741212
48Hyperglycinemia (HP:0002154)2.18676204
49Abnormality of renal resorption (HP:0011038)2.17170928
50Respiratory difficulties (HP:0002880)2.16385518
51Leukodystrophy (HP:0002415)2.16042611
52Glycosuria (HP:0003076)2.09769768
53Abnormality of urine glucose concentration (HP:0011016)2.09769768
54Congenital stationary night blindness (HP:0007642)2.08339699
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05589529
56Abnormal protein N-linked glycosylation (HP:0012347)2.05589529
57Abnormal protein glycosylation (HP:0012346)2.05589529
58Abnormal glycosylation (HP:0012345)2.05589529
59Opisthotonus (HP:0002179)2.04713784
60Muscle fiber atrophy (HP:0100295)2.02015515
61X-linked dominant inheritance (HP:0001423)2.01896569
62Emotional lability (HP:0000712)2.01765622
63Cerebral hypomyelination (HP:0006808)1.99188865
64Methylmalonic aciduria (HP:0012120)1.98501174
65Abnormal rod and cone electroretinograms (HP:0008323)1.97517789
66Dicarboxylic aciduria (HP:0003215)1.91979120
67Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91979120
68Retinal dysplasia (HP:0007973)1.91491468
69Rib fusion (HP:0000902)1.90990701
70Male pseudohermaphroditism (HP:0000037)1.90927527
71Hyperglycinuria (HP:0003108)1.89074606
72Septo-optic dysplasia (HP:0100842)1.87785583
73Vaginal atresia (HP:0000148)1.84012959
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.82797978
75Abnormality of alanine metabolism (HP:0010916)1.82675261
76Hyperalaninemia (HP:0003348)1.82675261
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82675261
78Genital tract atresia (HP:0001827)1.81613273
79Abnormality of the anterior horn cell (HP:0006802)1.81190918
80Degeneration of anterior horn cells (HP:0002398)1.81190918
81Hyperphosphaturia (HP:0003109)1.80437789
82Type II lissencephaly (HP:0007260)1.77961175
83Abnormality of cochlea (HP:0000375)1.77920234
84Degeneration of the lateral corticospinal tracts (HP:0002314)1.77087533
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77087533
86Median cleft lip (HP:0000161)1.76984136
87Short tibia (HP:0005736)1.76283117
88Abnormality of glycine metabolism (HP:0010895)1.73146746
89Abnormality of serine family amino acid metabolism (HP:0010894)1.73146746
90Absent septum pellucidum (HP:0001331)1.71787547
91Abolished electroretinogram (ERG) (HP:0000550)1.69966032
92Constricted visual fields (HP:0001133)1.69636282
93Cerebral palsy (HP:0100021)1.69040955
94Sclerocornea (HP:0000647)1.67682856
95Increased serum pyruvate (HP:0003542)1.66297848
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.66204983
97Growth hormone deficiency (HP:0000824)1.64217077
98Adrenal hypoplasia (HP:0000835)1.63272760
99Abnormality of serum amino acid levels (HP:0003112)1.63052286
100Stenosis of the external auditory canal (HP:0000402)1.61989151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.68519766
2STK163.31080102
3MAP4K22.77992299
4BCKDK2.71639014
5ZAK2.48975377
6BMPR1B2.37820163
7BUB12.31781898
8NUAK12.31331190
9EIF2AK32.28937314
10CDK192.06548683
11FRK2.03509233
12PLK41.98124992
13VRK11.94932358
14NME11.86722177
15STK38L1.85951830
16EIF2AK11.68280920
17CDC71.64313728
18INSRR1.60875165
19PIM21.51725177
20WNK31.47646589
21CSNK1G31.45866926
22PDK21.45081930
23PINK11.44510935
24BRSK21.37399441
25TLK11.34776126
26CSNK1G11.34409223
27ADRBK21.26865747
28CSNK1G21.25754120
29PLK31.25669756
30SRPK11.25022877
31OBSCN1.19973234
32NEK11.17513193
33CSNK1A1L1.16495240
34KDR1.14641846
35CDK81.14049977
36DYRK21.13819010
37MST41.12060170
38GRK11.11608375
39PHKG11.09249511
40PHKG21.09249511
41MAP3K41.08652946
42PLK11.03686669
43PLK21.03480221
44TNIK0.97482365
45LIMK10.93419042
46MAP2K70.91308532
47MYLK0.86843270
48TIE10.85578922
49PBK0.83303753
50NME20.82570706
51TAOK30.82304508
52PRKD30.80950464
53MAPK130.76829747
54OXSR10.76338776
55EIF2AK20.74006789
56MUSK0.71677780
57BRSK10.67672518
58DYRK30.67432313
59AURKB0.66567055
60MKNK10.66009723
61PRKCG0.65879251
62TGFBR10.65548411
63DAPK30.65291750
64TAF10.64730643
65PIK3CG0.63844904
66TNK20.63332165
67CSNK2A10.63133214
68GRK50.62750218
69ILK0.61961065
70STK40.61890343
71EPHA40.60515805
72DAPK10.60435502
73ERBB30.60191369
74CSNK2A20.59155556
75ABL20.57139708
76TRIM280.56905300
77BCR0.54976850
78ATR0.54497589
79TEC0.53844306
80TTK0.52244763
81AURKA0.52049798
82TESK10.50323558
83LRRK20.49956533
84CAMK2D0.49640884
85CASK0.49446238
86TESK20.48410024
87RPS6KA50.47129702
88KIT0.45872016
89MAPKAPK30.45617646
90MINK10.44781190
91PRKCE0.43332868
92CHEK20.43228400
93CAMK2A0.43068570
94ATM0.42899230
95PRKACA0.42675971
96ADRBK10.40063163
97PRKG10.39593600
98FGFR20.39021850
99CCNB10.37673525
100PKN10.36529609

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16262231
2Oxidative phosphorylation_Homo sapiens_hsa001904.13701684
3Proteasome_Homo sapiens_hsa030504.11399867
4Parkinsons disease_Homo sapiens_hsa050123.57728663
5Protein export_Homo sapiens_hsa030602.67833753
6RNA polymerase_Homo sapiens_hsa030202.65929792
7Huntingtons disease_Homo sapiens_hsa050162.49933788
8Alzheimers disease_Homo sapiens_hsa050102.29209733
9Mismatch repair_Homo sapiens_hsa034302.24442282
10Homologous recombination_Homo sapiens_hsa034402.16798096
11DNA replication_Homo sapiens_hsa030302.09262018
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95249780
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94282641
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89568165
15Cardiac muscle contraction_Homo sapiens_hsa042601.83707057
16Nucleotide excision repair_Homo sapiens_hsa034201.78429903
17Base excision repair_Homo sapiens_hsa034101.76251984
18Fatty acid elongation_Homo sapiens_hsa000621.71235257
19Propanoate metabolism_Homo sapiens_hsa006401.71036844
20Folate biosynthesis_Homo sapiens_hsa007901.70111745
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69650389
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65529828
23Fanconi anemia pathway_Homo sapiens_hsa034601.61896318
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60021204
25Basal transcription factors_Homo sapiens_hsa030221.59142868
26Pyrimidine metabolism_Homo sapiens_hsa002401.56433115
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55804187
28Sulfur relay system_Homo sapiens_hsa041221.50380533
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47071770
30RNA degradation_Homo sapiens_hsa030181.41674099
31Spliceosome_Homo sapiens_hsa030401.38332523
32Peroxisome_Homo sapiens_hsa041461.30923974
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30144147
34Pyruvate metabolism_Homo sapiens_hsa006201.24116728
35Regulation of autophagy_Homo sapiens_hsa041401.24018699
36Purine metabolism_Homo sapiens_hsa002301.22998257
37One carbon pool by folate_Homo sapiens_hsa006701.21878966
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16502943
39Butanoate metabolism_Homo sapiens_hsa006501.14666118
40Glutathione metabolism_Homo sapiens_hsa004801.14007972
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10062114
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06063629
43Tryptophan metabolism_Homo sapiens_hsa003800.98369393
44Non-homologous end-joining_Homo sapiens_hsa034500.93828951
45RNA transport_Homo sapiens_hsa030130.93654383
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.92713902
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92541375
48Metabolic pathways_Homo sapiens_hsa011000.92408925
49Sulfur metabolism_Homo sapiens_hsa009200.91025564
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90352942
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.83428125
52Fatty acid degradation_Homo sapiens_hsa000710.82407404
53Phototransduction_Homo sapiens_hsa047440.78891756
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77178004
55Chemical carcinogenesis_Homo sapiens_hsa052040.76097980
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75192744
57Nitrogen metabolism_Homo sapiens_hsa009100.73280235
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72968641
59Carbon metabolism_Homo sapiens_hsa012000.72202873
60Fatty acid metabolism_Homo sapiens_hsa012120.71630068
61Collecting duct acid secretion_Homo sapiens_hsa049660.70911798
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65868078
63beta-Alanine metabolism_Homo sapiens_hsa004100.64992172
64Retinol metabolism_Homo sapiens_hsa008300.62113227
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55966409
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55791875
67Arginine and proline metabolism_Homo sapiens_hsa003300.55753712
68Selenocompound metabolism_Homo sapiens_hsa004500.53275764
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52152959
70Nicotine addiction_Homo sapiens_hsa050330.52007511
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51889169
72Linoleic acid metabolism_Homo sapiens_hsa005910.51071238
73Arachidonic acid metabolism_Homo sapiens_hsa005900.49222586
74Biosynthesis of amino acids_Homo sapiens_hsa012300.46293575
75Caffeine metabolism_Homo sapiens_hsa002320.45707670
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45443946
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44722907
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40809103
79Cell cycle_Homo sapiens_hsa041100.40487528
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39976323
81Oocyte meiosis_Homo sapiens_hsa041140.37083227
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36976093
83Circadian rhythm_Homo sapiens_hsa047100.36798058
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35412752
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.34812420
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34000455
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32605978
88Hedgehog signaling pathway_Homo sapiens_hsa043400.32082395
89N-Glycan biosynthesis_Homo sapiens_hsa005100.31991197
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.31911378
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30603505
92Vitamin B6 metabolism_Homo sapiens_hsa007500.29825339
93Steroid biosynthesis_Homo sapiens_hsa001000.24357559
94Olfactory transduction_Homo sapiens_hsa047400.23670182
95Tyrosine metabolism_Homo sapiens_hsa003500.22990676
96Morphine addiction_Homo sapiens_hsa050320.21088721
97Glycerolipid metabolism_Homo sapiens_hsa005610.19471053
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19444539
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17869081
100Fat digestion and absorption_Homo sapiens_hsa049750.17278532

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