ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	9.18866092
2	cilium movement (GO:0003341)	8.90548020
3	epithelial cilium movement (GO:0003351)	8.55428659
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.28250775
5	axoneme assembly (GO:0035082)	6.94658003
6	motile cilium assembly (GO:0044458)	6.53064738
7	DNA deamination (GO:0045006)	5.81096117
8	regulation of cilium movement (GO:0003352)	5.59733822
9	cellular anion homeostasis (GO:0030002)	5.55407812
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.83228846
11	secondary heart field specification (GO:0003139)	4.69532640
12	heart field specification (GO:0003128)	4.69532640
13	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	4.43435122
14	L-fucose catabolic process (GO:0042355)	4.42748786
15	fucose catabolic process (GO:0019317)	4.42748786
16	L-fucose metabolic process (GO:0042354)	4.42748786
17	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.41894975
18	cilium organization (GO:0044782)	4.29911341
19	left/right axis specification (GO:0070986)	4.29422475
20	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.22275388
21	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.20421154
22	protein polyglutamylation (GO:0018095)	4.19060207
23	regulation of mesoderm development (GO:2000380)	4.16462685
24	cilium assembly (GO:0042384)	4.12336647
25	positive regulation of fibroblast migration (GO:0010763)	4.11455759
26	intraciliary transport (GO:0042073)	4.11348668
27	left/right pattern formation (GO:0060972)	4.06894188
28	somite rostral/caudal axis specification (GO:0032525)	4.01499818
29	sleep (GO:0030431)	3.99308365
30	fusion of sperm to egg plasma membrane (GO:0007342)	3.97514606
31	centriole replication (GO:0007099)	3.92350284
32	sperm motility (GO:0030317)	3.89250743
33	protein localization to cilium (GO:0061512)	3.77278490
34	positive regulation of cell fate commitment (GO:0010455)	3.76535377
35	exogenous drug catabolic process (GO:0042738)	3.76423978
36	microtubule bundle formation (GO:0001578)	3.63453101
37	behavioral response to nicotine (GO:0035095)	3.62672613
38	intra-S DNA damage checkpoint (GO:0031573)	3.59551938
39	centriole assembly (GO:0098534)	3.59087398
40	ventricular system development (GO:0021591)	3.44516324
41	cilium morphogenesis (GO:0060271)	3.44459315
42	cytidine deamination (GO:0009972)	3.41076865
43	cytidine metabolic process (GO:0046087)	3.41076865
44	cytidine catabolic process (GO:0006216)	3.41076865
45	growth hormone receptor signaling pathway (GO:0060396)	3.40754627
46	signal transduction involved in regulation of gene expression (GO:0023019)	3.39629441
47	regulation of microtubule-based movement (GO:0060632)	3.36362746
48	cellular response to growth hormone stimulus (GO:0071378)	3.34170832
49	retinal cone cell development (GO:0046549)	3.33339163
50	cardiac ventricle formation (GO:0003211)	3.32984527
51	cellular component assembly involved in morphogenesis (GO:0010927)	3.30511355
52	hydrogen peroxide biosynthetic process (GO:0050665)	3.28911443
53	intracellular pH reduction (GO:0051452)	3.28408306
54	negative regulation of cell fate specification (GO:0009996)	3.25835476
55	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.16374452
56	vitamin transmembrane transport (GO:0035461)	3.13808461
57	piRNA metabolic process (GO:0034587)	3.12454931
58	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.10898990
59	drug catabolic process (GO:0042737)	3.09708120
60	positive regulation of prostaglandin secretion (GO:0032308)	3.06461783
61	cell migration involved in heart development (GO:0060973)	3.05837128
62	DNA methylation involved in gamete generation (GO:0043046)	3.04318216
63	cell migration involved in gastrulation (GO:0042074)	3.04267201
64	cell projection assembly (GO:0030031)	3.03585023
65	necroptotic process (GO:0070266)	3.03068094
66	plasma membrane fusion (GO:0045026)	3.01384447
67	positive regulation of defense response to virus by host (GO:0002230)	3.01128817
68	sphingoid metabolic process (GO:0046519)	3.00108866
69	cardiac chamber formation (GO:0003207)	2.99437644
70	reactive oxygen species biosynthetic process (GO:1903409)	2.97904285
71	photoreceptor cell maintenance (GO:0045494)	2.97827313
72	diol metabolic process (GO:0034311)	2.96555952
73	specification of organ identity (GO:0010092)	2.95676690
74	spermatid development (GO:0007286)	2.94879988
75	platelet dense granule organization (GO:0060155)	2.93926967
76	sphingosine metabolic process (GO:0006670)	2.86408082
77	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.85062825
78	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.85062825
79	cellular ketone body metabolic process (GO:0046950)	2.84887323
80	regulation of neurotransmitter uptake (GO:0051580)	2.83215649
81	toxin metabolic process (GO:0009404)	2.82208860
82	negative regulation of cell fate commitment (GO:0010454)	2.81939912
83	one-carbon compound transport (GO:0019755)	2.80802506
84	seminiferous tubule development (GO:0072520)	2.80334803
85	single strand break repair (GO:0000012)	2.78863271
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.78550177
87	detection of light stimulus involved in visual perception (GO:0050908)	2.78550177
88	T-helper 1 type immune response (GO:0042088)	2.76370384
89	cytoplasmic microtubule organization (GO:0031122)	2.73094356
90	pH reduction (GO:0045851)	2.70175349
91	retinal rod cell development (GO:0046548)	2.66790535
92	positive regulation of interleukin-17 production (GO:0032740)	2.64588979
93	response to pheromone (GO:0019236)	2.59982666
94	glutathione derivative metabolic process (GO:1901685)	2.58658258
95	glutathione derivative biosynthetic process (GO:1901687)	2.58658258
96	multicellular organism reproduction (GO:0032504)	2.58367500
97	protein-chromophore linkage (GO:0018298)	2.57300783
98	cytokine biosynthetic process (GO:0042089)	2.55619712
99	ketone body metabolic process (GO:1902224)	2.55377393
100	axonemal dynein complex assembly (GO:0070286)	10.1816962

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.23288650
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77752483
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.69800441
4	VDR_22108803_ChIP-Seq_LS180_Human	2.58402717
5	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.45678440
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40489321
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.34141814
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23236132
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11949922
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09131074
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05422456
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.00088470
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89771338
14	P300_19829295_ChIP-Seq_ESCs_Human	1.89092221
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76777930
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.72571187
17	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.71756376
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69660403
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.69016557
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67129004
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67114503
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.67046448
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66736033
24	FUS_26573619_Chip-Seq_HEK293_Human	1.58575839
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57167404
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.55566083
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.54399866
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54399866
29	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.53681570
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.49864242
31	* STAT3_23295773_ChIP-Seq_U87_Human	1.49733781
32	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.46552278
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42732745
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41914956
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41409139
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.40047125
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40039495
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40039495
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39749471
40	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39735098
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39161770
42	TCF4_23295773_ChIP-Seq_U87_Human	1.38143417
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36951520
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36367489
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35020537
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35020537
47	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.33373938
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.32544614
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31181012
50	AR_25329375_ChIP-Seq_VCAP_Human	1.29284289
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.27225215
52	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.25546517
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24836064
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.24737627
55	AR_20517297_ChIP-Seq_VCAP_Human	1.24631471
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23465188
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22469311
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21914083
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.21851477
60	EWS_26573619_Chip-Seq_HEK293_Human	1.21516562
61	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.21269648
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21012787
63	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.19527019
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18554399
65	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17989951
66	DROSHA_22980978_ChIP-Seq_HELA_Human	1.17470318
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17125862
68	NCOR_22424771_ChIP-Seq_293T_Human	1.16286196
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14943269
70	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.14825090
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14602178
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14084976
73	* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13780890
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13721374
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12736625
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12716260
77	* PHF8_20622853_ChIP-Seq_HELA_Human	1.11621408
78	* TP53_22573176_ChIP-Seq_HFKS_Human	1.11134169
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10946371
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10681797
81	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08980246
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.08832685
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07949887
84	* PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07638511
85	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.07271490
86	AHR_22903824_ChIP-Seq_MCF-7_Human	1.07035838
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06616402
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06559909
89	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06559909
90	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.06343970
91	P300_18555785_Chip-Seq_ESCs_Mouse	1.06133595
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05729051
93	OCT4_20526341_ChIP-Seq_ESCs_Human	1.04932153
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04734923
95	* NFYA_21822215_ChIP-Seq_K562_Human	1.02630535
96	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01667669
97	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00974363
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00954685
99	* TBL1_22424771_ChIP-Seq_293T_Human	1.00943390
100	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.00727440

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	4.22792827
2	MP0003136_yellow_coat_color	4.17741070
3	MP0008875_abnormal_xenobiotic_pharmacok	4.03186950
4	MP0002653_abnormal_ependyma_morphology	3.97897336
5	MP0002837_dystrophic_cardiac_calcinosis	3.52162201
6	MP0003195_calcinosis	2.54399935
7	MP0001984_abnormal_olfaction	2.53241534
8	MP0001873_stomach_inflammation	2.52196200
9	MP0008877_abnormal_DNA_methylation	2.39246349
10	MP0005377_hearing/vestibular/ear_phenot	2.26713806
11	MP0003878_abnormal_ear_physiology	2.26713806
12	MP0005551_abnormal_eye_electrophysiolog	2.14299427
13	MP0004133_heterotaxia	2.09629892
14	MP0008872_abnormal_physiological_respon	2.08815366
15	MP0003646_muscle_fatigue	2.04069387
16	MP0002638_abnormal_pupillary_reflex	2.02571092
17	MP0004043_abnormal_pH_regulation	1.97507906
18	MP0002876_abnormal_thyroid_physiology	1.96100533
19	MP0008995_early_reproductive_senescence	1.79702259
20	MP0009046_muscle_twitch	1.74754612
21	MP0002160_abnormal_reproductive_system	1.72776591
22	MP0005253_abnormal_eye_physiology	1.68501516
23	MP0003880_abnormal_central_pattern	1.67287715
24	MP0005410_abnormal_fertilization	1.58002800
25	MP0005646_abnormal_pituitary_gland	1.55849811
26	MP0000465_gastrointestinal_hemorrhage	1.53726750
27	MP0005171_absent_coat_pigmentation	1.53017320
28	MP0001485_abnormal_pinna_reflex	1.52069133
29	MP0000569_abnormal_digit_pigmentation	1.48170101
30	MP0003011_delayed_dark_adaptation	1.48075849
31	MP0002102_abnormal_ear_morphology	1.43860660
32	MP0005085_abnormal_gallbladder_physiolo	1.43232550
33	MP0005389_reproductive_system_phenotype	1.42251245
34	MP0004142_abnormal_muscle_tone	1.38265525
35	MP0000383_abnormal_hair_follicle	1.36359403
36	MP0002909_abnormal_adrenal_gland	1.32183064
37	MP0002277_abnormal_respiratory_mucosa	1.30120831
38	MP0002938_white_spotting	1.27371301
39	MP0006072_abnormal_retinal_apoptosis	1.27084750
40	MP0003879_abnormal_hair_cell	1.25721132
41	MP0003698_abnormal_male_reproductive	1.24509533
42	MP0009745_abnormal_behavioral_response	1.23472895
43	MP0002132_abnormal_respiratory_system	1.22710375
44	MP0001501_abnormal_sleep_pattern	1.19568283
45	MP0005365_abnormal_bile_salt	1.15128776
46	MP0005645_abnormal_hypothalamus_physiol	1.14921493
47	MP0002272_abnormal_nervous_system	1.13924252
48	MP0001929_abnormal_gametogenesis	1.09360034
49	MP0000631_abnormal_neuroendocrine_gland	1.09322114
50	MP0000427_abnormal_hair_cycle	1.09216992
51	MP0005379_endocrine/exocrine_gland_phen	1.08558114
52	MP0006276_abnormal_autonomic_nervous	1.08435338
53	MP0001765_abnormal_ion_homeostasis	1.07236176
54	MP0003045_fibrosis	1.04426699
55	MP0001968_abnormal_touch/_nociception	1.02964373
56	MP0002928_abnormal_bile_duct	1.02767661
57	MP0010386_abnormal_urinary_bladder	1.02120489
58	MP0003787_abnormal_imprinting	1.01744223
59	MP0001764_abnormal_homeostasis	0.97208928
60	MP0009384_cardiac_valve_regurgitation	0.97070663
61	MP0000372_irregular_coat_pigmentation	0.96557592
62	MP0002229_neurodegeneration	0.94754820
63	MP0003890_abnormal_embryonic-extraembry	0.93642839
64	MP0002693_abnormal_pancreas_physiology	0.92745408
65	MP0005075_abnormal_melanosome_morpholog	0.91884190
66	MP0008789_abnormal_olfactory_epithelium	0.91478585
67	MP0006082_CNS_inflammation	0.90709995
68	MP0002736_abnormal_nociception_after	0.89645963
69	MP0001486_abnormal_startle_reflex	0.89544950
70	MP0004885_abnormal_endolymph	0.89185114
71	MP0002168_other_aberrant_phenotype	0.88937826
72	MP0010329_abnormal_lipoprotein_level	0.88923614
73	MP0004019_abnormal_vitamin_homeostasis	0.88894934
74	MP0002735_abnormal_chemical_nociception	0.88818838
75	MP0001324_abnormal_eye_pigmentation	0.88579867
76	MP0005195_abnormal_posterior_eye	0.87499557
77	MP0001970_abnormal_pain_threshold	0.86046348
78	MP0005636_abnormal_mineral_homeostasis	0.84043369
79	MP0000026_abnormal_inner_ear	0.82398357
80	MP0000639_abnormal_adrenal_gland	0.82375771
81	MP0001963_abnormal_hearing_physiology	0.81404262
82	MP0001529_abnormal_vocalization	0.80977314
83	MP0004130_abnormal_muscle_cell	0.80014345
84	MP0001905_abnormal_dopamine_level	0.79839837
85	MP0003950_abnormal_plasma_membrane	0.79270667
86	MP0002163_abnormal_gland_morphology	0.78812266
87	MP0006292_abnormal_olfactory_placode	0.78391867
88	MP0001664_abnormal_digestion	0.77140562
89	MP0004215_abnormal_myocardial_fiber	0.77018244
90	MP0004782_abnormal_surfactant_physiolog	0.76754257
91	MP0004145_abnormal_muscle_electrophysio	0.76172251
92	MP0005332_abnormal_amino_acid	0.73275668
93	MP0000013_abnormal_adipose_tissue	0.73082850
94	MP0001661_extended_life_span	0.72687184
95	MP0002572_abnormal_emotion/affect_behav	0.72055291
96	MP0000230_abnormal_systemic_arterial	0.71274838
97	MP0005174_abnormal_tail_pigmentation	0.70583491
98	MP0008775_abnormal_heart_ventricle	0.70192510
99	MP0002210_abnormal_sex_determination	0.68577975
100	MP0005448_abnormal_energy_balance	0.68569636

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.35762582
2	Abnormal respiratory motile cilium morphology (HP:0005938)	7.06980622
3	Abnormal respiratory epithelium morphology (HP:0012253)	7.06980622
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.05034221
5	Absent/shortened dynein arms (HP:0200106)	7.05034221
6	Abnormal ciliary motility (HP:0012262)	7.03530059
7	Abnormal respiratory motile cilium physiology (HP:0012261)	6.89367162
8	Rhinitis (HP:0012384)	6.29150845
9	True hermaphroditism (HP:0010459)	4.59850395
10	Autoimmune thrombocytopenia (HP:0001973)	4.55705075
11	Bronchiectasis (HP:0002110)	4.51122448
12	Chronic bronchitis (HP:0004469)	4.51020544
13	Pancreatic fibrosis (HP:0100732)	4.14823248
14	Pancreatic cysts (HP:0001737)	4.14580834
15	Nephronophthisis (HP:0000090)	3.67461368
16	Abnormality of midbrain morphology (HP:0002418)	3.62364540
17	Molar tooth sign on MRI (HP:0002419)	3.62364540
18	Chronic hepatic failure (HP:0100626)	3.51559466
19	Autoimmune hemolytic anemia (HP:0001890)	3.51350734
20	Increased IgM level (HP:0003496)	3.34219892
21	Nasal polyposis (HP:0100582)	3.27060749
22	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.19899965
23	Abnormality of the renal medulla (HP:0100957)	3.15662711
24	Birth length less than 3rd percentile (HP:0003561)	3.13524727
25	Cystic liver disease (HP:0006706)	3.10070702
26	Medial flaring of the eyebrow (HP:0010747)	3.09951641
27	Occipital encephalocele (HP:0002085)	3.07939049
28	Infertility (HP:0000789)	2.91244986
29	Male pseudohermaphroditism (HP:0000037)	2.85671612
30	Chronic sinusitis (HP:0011109)	2.76678634
31	Recurrent sinusitis (HP:0011108)	2.70922870
32	Bronchitis (HP:0012387)	2.65168560
33	Abnormality of macular pigmentation (HP:0008002)	2.62147915
34	Male infertility (HP:0003251)	2.61158308
35	Lip pit (HP:0100267)	2.60786844
36	Congenital stationary night blindness (HP:0007642)	2.56214063
37	Abnormality of the renal cortex (HP:0011035)	2.55854245
38	Abnormality of the nasal mucosa (HP:0000433)	2.55378941
39	Type II lissencephaly (HP:0007260)	2.54928027
40	Anterior segment dysgenesis (HP:0007700)	2.53773124
41	Insulin-resistant diabetes mellitus (HP:0000831)	2.50232047
42	Eosinophilia (HP:0001880)	2.39707591
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.39663440
44	Congenital hepatic fibrosis (HP:0002612)	2.35804222
45	Tubulointerstitial nephritis (HP:0001970)	2.32802374
46	Decreased circulating renin level (HP:0003351)	2.30973868
47	Tubular atrophy (HP:0000092)	2.30932851
48	Hypochromic anemia (HP:0001931)	2.30007844
49	Glucose intolerance (HP:0000833)	2.29544474
50	Enlarged epiphyses (HP:0010580)	2.25265723
51	Depressed nasal tip (HP:0000437)	2.21289224
52	Gait imbalance (HP:0002141)	2.19092363
53	Congenital primary aphakia (HP:0007707)	2.17804571
54	Abnormality of eosinophils (HP:0001879)	2.15246160
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14224247
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14224247
57	Neonatal hypoglycemia (HP:0001998)	2.12374839
58	Postaxial foot polydactyly (HP:0001830)	2.11625325
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10153642
60	Large for gestational age (HP:0001520)	2.06623536
61	Anencephaly (HP:0002323)	2.05013165
62	Polydipsia (HP:0001959)	2.03081950
63	Abnormal drinking behavior (HP:0030082)	2.03081950
64	Sclerocornea (HP:0000647)	2.01399451
65	Gonadal dysgenesis (HP:0000133)	1.97793903
66	Gaze-evoked nystagmus (HP:0000640)	1.97725803
67	Furrowed tongue (HP:0000221)	1.96789087
68	Nephrogenic diabetes insipidus (HP:0009806)	1.91589560
69	Abnormality of T cell number (HP:0011839)	1.89833608
70	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.89833170
71	Hypoplasia of the fovea (HP:0007750)	1.89833170
72	Cerebellar dysplasia (HP:0007033)	1.89776940
73	Hyperglycemia (HP:0003074)	1.87908577
74	Decreased central vision (HP:0007663)	1.87568231
75	Progressive cerebellar ataxia (HP:0002073)	1.86574247
76	Chin dimple (HP:0010751)	1.82993281
77	Sparse lateral eyebrow (HP:0005338)	1.81193416
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80487025
79	Recurrent otitis media (HP:0000403)	1.78576663
80	Amelogenesis imperfecta (HP:0000705)	1.77161144
81	Epileptic encephalopathy (HP:0200134)	1.77106054
82	Constricted visual fields (HP:0001133)	1.76709618
83	Oculomotor apraxia (HP:0000657)	1.75357725
84	Tubulointerstitial abnormality (HP:0001969)	1.74738533
85	Retinal dysplasia (HP:0007973)	1.74525640
86	Postaxial hand polydactyly (HP:0001162)	1.71193649
87	Chronic otitis media (HP:0000389)	1.69913287
88	Bile duct proliferation (HP:0001408)	1.69372517
89	Abnormal biliary tract physiology (HP:0012439)	1.69372517
90	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.68537038
91	Myotonia (HP:0002486)	1.67027376
92	Genital tract atresia (HP:0001827)	1.61586945
93	Abnormality of the fovea (HP:0000493)	1.60901753
94	Attenuation of retinal blood vessels (HP:0007843)	1.60867576
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.60781408
96	Genetic anticipation (HP:0003743)	1.60708857
97	Stage 5 chronic kidney disease (HP:0003774)	1.60278666
98	Abnormality of T cell physiology (HP:0011840)	1.59945680
99	Granulocytopenia (HP:0001913)	1.59431827
100	Asplenia (HP:0001746)	1.57653256

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.14155398
2	FRK	4.89367116
3	PIK3CA	4.29805665
4	CDK19	3.23306665
5	MAPK15	2.97513991
6	STK38L	2.56646029
7	MAP4K2	2.45501974
8	OXSR1	2.22034098
9	LATS1	2.13722530
10	BMPR1B	2.13491732
11	INSRR	2.03641575
12	CAMKK2	1.90412934
13	ADRBK2	1.85489621
14	WNK3	1.83053374
15	ACVR1B	1.79055342
16	MST4	1.72296334
17	PINK1	1.58260658
18	GRK7	1.46872104
19	GRK1	1.38535255
20	ZAK	1.37973706
21	KIT	1.36176137
22	MAP2K6	1.25162444
23	CAMK1D	1.23285112
24	TXK	1.17002597
25	PRKCG	1.14776352
26	ADRBK1	1.13996561
27	NLK	1.11394578
28	PTK2B	1.09225864
29	PLK2	1.07793321
30	PLK4	1.06427002
31	BMPR2	1.05241851
32	MAP3K4	1.01653414
33	WNK4	0.98797336
34	CAMK1G	0.97780400
35	STK10	0.93023286
36	MAP3K6	0.84982039
37	STK3	0.84185970
38	NUAK1	0.82621663
39	PRKD3	0.81888365
40	STK38	0.76465111
41	RET	0.76007959
42	TRPM7	0.73128230
43	MAPK13	0.72814348
44	PAK3	0.72777370
45	TAOK3	0.72763773
46	MAPK12	0.69607745
47	TRIM28	0.67074517
48	BRSK2	0.61675617
49	BCKDK	0.61303522
50	GRK6	0.60810348
51	GRK5	0.60593300
52	CSNK1G2	0.59402655
53	NME1	0.55970737
54	PRKCE	0.55743727
55	EPHA3	0.55378056
56	STK11	0.52529008
57	TNK2	0.52426542
58	MAP2K7	0.50983796
59	FER	0.50075545
60	PRKAA2	0.49467379
61	ERBB3	0.48181122
62	PHKG2	0.47976321
63	PHKG1	0.47976321
64	TNIK	0.47798250
65	PIK3CG	0.46793661
66	CSNK1G1	0.46678691
67	PRKACA	0.46308289
68	MAP2K2	0.46076207
69	MAP2K4	0.45327502
70	STK39	0.45145165
71	CAMK2A	0.42954165
72	CAMKK1	0.42275224
73	PRKG1	0.41372299
74	DAPK2	0.40740486
75	CSNK1G3	0.40420489
76	PRKCQ	0.39273301
77	MARK3	0.39128774
78	TGFBR1	0.38923955
79	IGF1R	0.37397164
80	PRKD1	0.37067652
81	CSNK1D	0.35911480
82	MUSK	0.35885897
83	CAMK1	0.35596792
84	PTK2	0.35238853
85	MAPKAPK3	0.34922239
86	PDK2	0.34601319
87	CSNK1A1L	0.34272625
88	MAP3K2	0.34137880
89	PRKCI	0.33572066
90	PNCK	0.32317915
91	TGFBR2	0.31598476
92	STK24	0.31316664
93	IKBKB	0.31245331
94	NTRK3	0.31046680
95	PRKCA	0.31037768
96	IRAK1	0.27520978
97	BCR	0.27349900
98	FGFR2	0.27205654
99	VRK1	0.24753821
100	MKNK2	0.23688782

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.52752945
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.73301091
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.64730924
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61837233
5	Phototransduction_Homo sapiens_hsa04744	2.53170223
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46425803
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.34252306
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.32742558
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.29259723
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.28152037
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.24565048
12	African trypanosomiasis_Homo sapiens_hsa05143	2.20170270
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.08957005
14	Allograft rejection_Homo sapiens_hsa05330	2.06040495
15	Butanoate metabolism_Homo sapiens_hsa00650	1.92727495
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.90249232
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89196732
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.88284935
19	ABC transporters_Homo sapiens_hsa02010	1.86878158
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.83039890
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81221387
22	beta-Alanine metabolism_Homo sapiens_hsa00410	1.71766879
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54190860
24	Histidine metabolism_Homo sapiens_hsa00340	1.50788965
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.49300047
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48777411
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44023812
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38486340
29	Nicotine addiction_Homo sapiens_hsa05033	1.37682699
30	Retinol metabolism_Homo sapiens_hsa00830	1.37103601
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.32262911
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.26056354
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23902518
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.22082923
35	Olfactory transduction_Homo sapiens_hsa04740	1.21838226
36	Propanoate metabolism_Homo sapiens_hsa00640	1.19937673
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16159994
38	Peroxisome_Homo sapiens_hsa04146	1.14604188
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13453095
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.12992630
41	Taste transduction_Homo sapiens_hsa04742	1.12979963
42	Protein export_Homo sapiens_hsa03060	1.07187557
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01669999
44	Huntingtons disease_Homo sapiens_hsa05016	0.99678237
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98241504
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95359499
47	Glutathione metabolism_Homo sapiens_hsa00480	0.95079899
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93054122
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.85636299
50	Asthma_Homo sapiens_hsa05310	0.84895850
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82857900
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.82386553
53	Salivary secretion_Homo sapiens_hsa04970	0.79985628
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78830814
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77271572
56	Insulin secretion_Homo sapiens_hsa04911	0.75187696
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74133267
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73606677
59	Morphine addiction_Homo sapiens_hsa05032	0.72291302
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71268037
61	RNA polymerase_Homo sapiens_hsa03020	0.69731331
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.69198943
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68730855
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.67644401
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66723952
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65056179
67	Circadian rhythm_Homo sapiens_hsa04710	0.62673146
68	Fatty acid degradation_Homo sapiens_hsa00071	0.61796370
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.61482458
70	Homologous recombination_Homo sapiens_hsa03440	0.60253166
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58495552
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.58136712
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55534843
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54273907
75	GABAergic synapse_Homo sapiens_hsa04727	0.53006602
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51219398
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50969111
78	Serotonergic synapse_Homo sapiens_hsa04726	0.49238227
79	Metabolic pathways_Homo sapiens_hsa01100	0.49003575
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48069776
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47018794
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45432647
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45413045
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45043001
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39371327
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39093071
87	Purine metabolism_Homo sapiens_hsa00230	0.38462592
88	Basal transcription factors_Homo sapiens_hsa03022	0.37320938
89	Fatty acid elongation_Homo sapiens_hsa00062	0.36342156
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34310499
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34154920
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32992873
93	Regulation of autophagy_Homo sapiens_hsa04140	0.31023944
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28118002
95	One carbon pool by folate_Homo sapiens_hsa00670	0.27683235
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.26231553
97	Renin secretion_Homo sapiens_hsa04924	0.25400179
98	Mineral absorption_Homo sapiens_hsa04978	0.25112746
99	Parkinsons disease_Homo sapiens_hsa05012	0.24957505
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.22869094

C1ORF141

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »