ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.69584528
2	synapsis (GO:0007129)	5.30078510
3	regulation of meiosis I (GO:0060631)	5.13789278
4	male meiosis I (GO:0007141)	5.05210276
5	DNA methylation involved in gamete generation (GO:0043046)	4.99344628
6	male meiosis (GO:0007140)	4.20563954
7	response to pheromone (GO:0019236)	3.99472540
8	chromosome organization involved in meiosis (GO:0070192)	3.87145822
9	meiosis I (GO:0007127)	3.83850970
10	ubiquinone biosynthetic process (GO:0006744)	3.81157496
11	reciprocal meiotic recombination (GO:0007131)	3.79757444
12	reciprocal DNA recombination (GO:0035825)	3.79757444
13	axoneme assembly (GO:0035082)	3.76004474
14	centriole replication (GO:0007099)	3.61829746
15	replication fork processing (GO:0031297)	3.55594149
16	DNA deamination (GO:0045006)	3.54930046
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.51124341
18	resolution of meiotic recombination intermediates (GO:0000712)	3.47073120
19	behavioral response to nicotine (GO:0035095)	3.46485411
20	respiratory chain complex IV assembly (GO:0008535)	3.44510369
21	fucose catabolic process (GO:0019317)	3.34756739
22	L-fucose metabolic process (GO:0042354)	3.34756739
23	L-fucose catabolic process (GO:0042355)	3.34756739
24	cell wall macromolecule metabolic process (GO:0044036)	3.33484194
25	positive regulation of meiosis (GO:0045836)	3.32802005
26	retinal cone cell development (GO:0046549)	3.32012366
27	ubiquinone metabolic process (GO:0006743)	3.31840931
28	negative regulation of cAMP-mediated signaling (GO:0043951)	3.31709323
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30816951
30	meiotic nuclear division (GO:0007126)	3.25442683
31	synaptonemal complex organization (GO:0070193)	3.25087612
32	maturation of 5.8S rRNA (GO:0000460)	3.24366381
33	cellular ketone body metabolic process (GO:0046950)	3.19728673
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18109445
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18109445
36	DNA replication-dependent nucleosome assembly (GO:0006335)	3.17808726
37	DNA replication-dependent nucleosome organization (GO:0034723)	3.17808726
38	indole-containing compound catabolic process (GO:0042436)	3.17801495
39	indolalkylamine catabolic process (GO:0046218)	3.17801495
40	tryptophan catabolic process (GO:0006569)	3.17801495
41	mannosylation (GO:0097502)	3.11833050
42	gene silencing by RNA (GO:0031047)	3.11677027
43	water-soluble vitamin biosynthetic process (GO:0042364)	3.11293738
44	quinone biosynthetic process (GO:1901663)	3.08429111
45	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.08380533
46	regulation of mitotic spindle checkpoint (GO:1903504)	3.08380533
47	positive regulation of meiotic cell cycle (GO:0051446)	3.05257016
48	ketone body metabolic process (GO:1902224)	3.02738486
49	protein K11-linked deubiquitination (GO:0035871)	3.02702243
50	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.02359672
51	rhodopsin mediated signaling pathway (GO:0016056)	2.97236934
52	double-strand break repair via homologous recombination (GO:0000724)	2.92417093
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90900096
54	NADH dehydrogenase complex assembly (GO:0010257)	2.90900096
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90900096
56	cytochrome complex assembly (GO:0017004)	2.90594642
57	synaptonemal complex assembly (GO:0007130)	2.90219921
58	epithelial cilium movement (GO:0003351)	2.90178399
59	recombinational repair (GO:0000725)	2.89794318
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.89683747
61	indolalkylamine metabolic process (GO:0006586)	2.84380151
62	meiotic cell cycle process (GO:1903046)	2.84299733
63	meiotic cell cycle (GO:0051321)	2.77836087
64	protein complex biogenesis (GO:0070271)	2.76837973
65	DNA double-strand break processing (GO:0000729)	2.76577673
66	proteasome assembly (GO:0043248)	2.72981097
67	platelet dense granule organization (GO:0060155)	2.72855551
68	meiotic chromosome segregation (GO:0045132)	2.71829432
69	behavioral response to ethanol (GO:0048149)	2.70720460
70	photoreceptor cell maintenance (GO:0045494)	2.69754643
71	tryptophan metabolic process (GO:0006568)	2.65765185
72	kynurenine metabolic process (GO:0070189)	2.64160039
73	negative regulation of telomere maintenance (GO:0032205)	2.63549019
74	detection of light stimulus involved in sensory perception (GO:0050962)	2.63150366
75	detection of light stimulus involved in visual perception (GO:0050908)	2.63150366
76	inositol phosphate catabolic process (GO:0071545)	2.62887301
77	postreplication repair (GO:0006301)	2.61711032
78	cilium morphogenesis (GO:0060271)	2.61438015
79	cilium or flagellum-dependent cell motility (GO:0001539)	2.60251813
80	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.59791346
81	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.59791346
82	tRNA processing (GO:0008033)	2.59516051
83	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58634126
84	isotype switching (GO:0045190)	2.58634126
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58634126
86	translesion synthesis (GO:0019985)	2.58380746
87	regulation of acrosome reaction (GO:0060046)	2.57712009
88	inositol phosphate dephosphorylation (GO:0046855)	2.56452217
89	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.56452217
90	cilium organization (GO:0044782)	2.56447362
91	protein-cofactor linkage (GO:0018065)	2.56021587
92	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56001425
93	photoreceptor cell development (GO:0042461)	2.55115247
94	nucleotide transmembrane transport (GO:1901679)	2.54557304
95	multicellular organism reproduction (GO:0032504)	2.54139881
96	cilium assembly (GO:0042384)	2.53646708
97	female gamete generation (GO:0007292)	2.52842468
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51459571
99	branched-chain amino acid catabolic process (GO:0009083)	2.50635056
100	tachykinin receptor signaling pathway (GO:0007217)	2.49471559

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.15671256
2	VDR_22108803_ChIP-Seq_LS180_Human	3.12259175
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10924674
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.02155240
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.94086998
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63874563
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56757134
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.37548025
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.37514155
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36933572
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31652734
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29228333
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24608981
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16620944
15	FUS_26573619_Chip-Seq_HEK293_Human	2.09031120
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07696140
17	EWS_26573619_Chip-Seq_HEK293_Human	2.05844276
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98985816
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97608808
20	P300_19829295_ChIP-Seq_ESCs_Human	1.94397725
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.89604967
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.87370507
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86313310
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82123067
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81972295
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79248072
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.70544871
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64478805
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.62367120
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.61870003
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.60238811
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57893273
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.57184808
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56980600
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56533162
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54773055
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53991253
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53991253
39	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51868247
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49769372
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47364503
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46590044
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.43850484
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43284012
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43284012
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42066246
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.42066246
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40442799
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40442799
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38913953
51	STAT3_23295773_ChIP-Seq_U87_Human	1.38813857
52	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38638282
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38230429
54	TCF4_23295773_ChIP-Seq_U87_Human	1.35941599
55	AR_25329375_ChIP-Seq_VCAP_Human	1.35872876
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35077931
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32681255
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30737763
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29291777
60	AR_20517297_ChIP-Seq_VCAP_Human	1.28252292
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26702548
62	* TCF4_22108803_ChIP-Seq_LS180_Human	1.25963348
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24490495
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23810691
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22656365
66	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20471819
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20400163
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19233055
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19225631
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17964757
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17757109
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17662532
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17323605
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17102365
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16861345
76	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16590897
77	NCOR_22424771_ChIP-Seq_293T_Human	1.15050648
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.14970848
79	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.14876291
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14700350
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14360382
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14102827
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13921719
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13650834
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12216528
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11318940
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10373363
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09270383
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07867812
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05958836
91	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05651195
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04800991
93	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04353773
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04242331
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04035441
96	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02962168
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02881434
98	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01194759
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01041125
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99310251

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.31152035
2	MP0003136_yellow_coat_color	3.84247445
3	MP0000372_irregular_coat_pigmentation	3.22801451
4	MP0002102_abnormal_ear_morphology	3.01215038
5	MP0003718_maternal_effect	2.55176858
6	MP0005551_abnormal_eye_electrophysiolog	2.49424752
7	MP0002653_abnormal_ependyma_morphology	2.49342134
8	MP0002138_abnormal_hepatobiliary_system	2.45484003
9	MP0002638_abnormal_pupillary_reflex	2.40490258
10	MP0004147_increased_porphyrin_level	2.37267085
11	MP0008058_abnormal_DNA_repair	2.31904443
12	MP0008875_abnormal_xenobiotic_pharmacok	1.95310897
13	MP0001968_abnormal_touch/_nociception	1.94765461
14	MP0005174_abnormal_tail_pigmentation	1.94010160
15	MP0003880_abnormal_central_pattern	1.87698483
16	MP0005075_abnormal_melanosome_morpholog	1.86996891
17	MP0003646_muscle_fatigue	1.82307173
18	MP0002837_dystrophic_cardiac_calcinosis	1.80322857
19	MP0001984_abnormal_olfaction	1.79849726
20	MP0008872_abnormal_physiological_respon	1.77685892
21	MP0005645_abnormal_hypothalamus_physiol	1.77382323
22	MP0000569_abnormal_digit_pigmentation	1.72268577
23	MP0002876_abnormal_thyroid_physiology	1.70538543
24	MP0005646_abnormal_pituitary_gland	1.70178721
25	MP0000015_abnormal_ear_pigmentation	1.69523066
26	MP0002095_abnormal_skin_pigmentation	1.66597591
27	MP0001929_abnormal_gametogenesis	1.63443038
28	MP0008995_early_reproductive_senescence	1.62644315
29	MP0002210_abnormal_sex_determination	1.61838203
30	MP0005253_abnormal_eye_physiology	1.60244406
31	MP0005389_reproductive_system_phenotype	1.58008275
32	MP0002160_abnormal_reproductive_system	1.57950274
33	MP0006072_abnormal_retinal_apoptosis	1.57871611
34	MP0000383_abnormal_hair_follicle	1.50820281
35	MP0002736_abnormal_nociception_after	1.47193605
36	MP0000427_abnormal_hair_cycle	1.43796016
37	MP0005084_abnormal_gallbladder_morpholo	1.42068829
38	MP0003698_abnormal_male_reproductive	1.41459619
39	MP0002928_abnormal_bile_duct	1.41092290
40	MP0009046_muscle_twitch	1.35715723
41	MP0006292_abnormal_olfactory_placode	1.33409016
42	MP0003195_calcinosis	1.32460286
43	MP0005410_abnormal_fertilization	1.30414479
44	MP0002272_abnormal_nervous_system	1.28247094
45	MP0000653_abnormal_sex_gland	1.28170300
46	MP0005379_endocrine/exocrine_gland_phen	1.27843544
47	MP0008789_abnormal_olfactory_epithelium	1.27835789
48	MP0004133_heterotaxia	1.25141088
49	MP0002735_abnormal_chemical_nociception	1.24923795
50	MP0010094_abnormal_chromosome_stability	1.24727132
51	MP0000631_abnormal_neuroendocrine_gland	1.23339200
52	MP0001986_abnormal_taste_sensitivity	1.23127417
53	MP0001145_abnormal_male_reproductive	1.21193553
54	MP0001501_abnormal_sleep_pattern	1.19840950
55	MP0002163_abnormal_gland_morphology	1.19605580
56	MP0003786_premature_aging	1.19177389
57	MP0009745_abnormal_behavioral_response	1.17830460
58	MP0002234_abnormal_pharynx_morphology	1.16140461
59	MP0001919_abnormal_reproductive_system	1.15578683
60	MP0006276_abnormal_autonomic_nervous	1.13890641
61	MP0003252_abnormal_bile_duct	1.12289610
62	MP0003787_abnormal_imprinting	1.11773542
63	MP0006036_abnormal_mitochondrial_physio	1.09793174
64	MP0005171_absent_coat_pigmentation	1.09193840
65	MP0002938_white_spotting	1.07696644
66	MP0001486_abnormal_startle_reflex	1.05688749
67	MP0001764_abnormal_homeostasis	1.03490462
68	MP0002733_abnormal_thermal_nociception	1.00597592
69	MP0004043_abnormal_pH_regulation	1.00190508
70	MP0004215_abnormal_myocardial_fiber	0.98950010
71	MP0001119_abnormal_female_reproductive	0.97982848
72	MP0001970_abnormal_pain_threshold	0.97288958
73	MP0001324_abnormal_eye_pigmentation	0.96181706
74	MP0004142_abnormal_muscle_tone	0.95826339
75	MP0003121_genomic_imprinting	0.93705239
76	MP0001529_abnormal_vocalization	0.93314823
77	MP0002277_abnormal_respiratory_mucosa	0.93054293
78	MP0005085_abnormal_gallbladder_physiolo	0.92044305
79	MP0003806_abnormal_nucleotide_metabolis	0.91037250
80	MP0002734_abnormal_mechanical_nocicepti	0.90088895
81	MP0010386_abnormal_urinary_bladder	0.88582672
82	MP0002751_abnormal_autonomic_nervous	0.88003817
83	MP0005195_abnormal_posterior_eye	0.87918020
84	MP0004924_abnormal_behavior	0.83643336
85	MP0005386_behavior/neurological_phenoty	0.83643336
86	MP0010678_abnormal_skin_adnexa	0.82703641
87	MP0002229_neurodegeneration	0.79221780
88	MP0005310_abnormal_salivary_gland	0.77654033
89	MP0001905_abnormal_dopamine_level	0.75058936
90	MP0001485_abnormal_pinna_reflex	0.73706498
91	MP0002572_abnormal_emotion/affect_behav	0.73357967
92	MP0004885_abnormal_endolymph	0.71209443
93	MP0003186_abnormal_redox_activity	0.71088661
94	MP0002161_abnormal_fertility/fecundity	0.70275606
95	MP0003950_abnormal_plasma_membrane	0.70178727
96	MP0005332_abnormal_amino_acid	0.70167890
97	MP0000026_abnormal_inner_ear	0.69956804
98	MP0000647_abnormal_sebaceous_gland	0.67235646
99	MP0009697_abnormal_copulation	0.66823068
100	MP0005394_taste/olfaction_phenotype	0.65220754

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57690947
2	True hermaphroditism (HP:0010459)	4.25811572
3	Pancreatic fibrosis (HP:0100732)	4.01578213
4	Congenital stationary night blindness (HP:0007642)	3.78673924
5	Abnormality of midbrain morphology (HP:0002418)	3.52233276
6	Molar tooth sign on MRI (HP:0002419)	3.52233276
7	Medial flaring of the eyebrow (HP:0010747)	3.16605531
8	Nephronophthisis (HP:0000090)	3.10634740
9	Attenuation of retinal blood vessels (HP:0007843)	3.04695167
10	Abnormality of the renal cortex (HP:0011035)	2.94794275
11	Cystic liver disease (HP:0006706)	2.86470560
12	Abnormal rod and cone electroretinograms (HP:0008323)	2.84694433
13	Nephrogenic diabetes insipidus (HP:0009806)	2.82448049
14	Abnormality of macular pigmentation (HP:0008002)	2.80170872
15	Congenital hepatic fibrosis (HP:0002612)	2.77893489
16	Abnormality of the renal medulla (HP:0100957)	2.74272782
17	Chronic hepatic failure (HP:0100626)	2.71496441
18	Congenital primary aphakia (HP:0007707)	2.69999044
19	Absent/shortened dynein arms (HP:0200106)	2.68059741
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68059741
21	Gait imbalance (HP:0002141)	2.67057754
22	Type I transferrin isoform profile (HP:0003642)	2.66590737
23	Male pseudohermaphroditism (HP:0000037)	2.65978415
24	Renal cortical cysts (HP:0000803)	2.64409016
25	Fair hair (HP:0002286)	2.63491063
26	Type II lissencephaly (HP:0007260)	2.63257041
27	Congenital, generalized hypertrichosis (HP:0004540)	2.61888690
28	Sclerocornea (HP:0000647)	2.61296553
29	Progressive inability to walk (HP:0002505)	2.56914406
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.49083723
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.49083723
32	Abnormal protein glycosylation (HP:0012346)	2.49083723
33	Abnormal glycosylation (HP:0012345)	2.49083723
34	Abnormality of the fovea (HP:0000493)	2.48605325
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.48307884
36	Bile duct proliferation (HP:0001408)	2.44578779
37	Abnormal biliary tract physiology (HP:0012439)	2.44578779
38	Postaxial foot polydactyly (HP:0001830)	2.40729265
39	Hyperglycinuria (HP:0003108)	2.40165873
40	Abolished electroretinogram (ERG) (HP:0000550)	2.39972308
41	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39182635
42	Large for gestational age (HP:0001520)	2.36953495
43	Generalized hypopigmentation of hair (HP:0011358)	2.25721934
44	Abnormal drinking behavior (HP:0030082)	2.24677946
45	Polydipsia (HP:0001959)	2.24677946
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24414557
47	Tubular atrophy (HP:0000092)	2.21444942
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21257964
49	Cerebellar dysplasia (HP:0007033)	2.20649113
50	Volvulus (HP:0002580)	2.20306100
51	3-Methylglutaconic aciduria (HP:0003535)	2.16463647
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.16163614
53	Hypoplasia of the fovea (HP:0007750)	2.16163614
54	Methylmalonic acidemia (HP:0002912)	2.12998601
55	Azoospermia (HP:0000027)	2.06904701
56	Pendular nystagmus (HP:0012043)	2.06876159
57	Keratoconus (HP:0000563)	2.05894770
58	Increased corneal curvature (HP:0100692)	2.05894770
59	Furrowed tongue (HP:0000221)	2.05792934
60	Oligodactyly (hands) (HP:0001180)	2.05746232
61	Hyperglycinemia (HP:0002154)	2.04339256
62	Anencephaly (HP:0002323)	2.02726245
63	Genital tract atresia (HP:0001827)	2.02687096
64	Short tibia (HP:0005736)	2.00926186
65	Abnormal ciliary motility (HP:0012262)	2.00516067
66	Intestinal atresia (HP:0011100)	2.00395091
67	Mitochondrial inheritance (HP:0001427)	2.00264251
68	Dry hair (HP:0011359)	1.99277537
69	Hypoproteinemia (HP:0003075)	1.99053837
70	Inability to walk (HP:0002540)	1.98175076
71	Postaxial hand polydactyly (HP:0001162)	1.98071540
72	Abnormality of the ileum (HP:0001549)	1.97410679
73	Abnormality of glycine metabolism (HP:0010895)	1.97040778
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.97040778
75	Hyperalaninemia (HP:0003348)	1.96813912
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96813912
77	Abnormality of alanine metabolism (HP:0010916)	1.96813912
78	Increased CSF lactate (HP:0002490)	1.96267257
79	Abnormal respiratory motile cilium morphology (HP:0005938)	1.95220474
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.95220474
81	Preaxial hand polydactyly (HP:0001177)	1.94499131
82	Supernumerary spleens (HP:0009799)	1.94130108
83	Neonatal respiratory distress (HP:0002643)	1.93384523
84	Hypomagnesemia (HP:0002917)	1.91934490
85	Vaginal atresia (HP:0000148)	1.89290355
86	Median cleft lip (HP:0000161)	1.88358265
87	Ketoacidosis (HP:0001993)	1.87542448
88	Decreased central vision (HP:0007663)	1.86651398
89	Acute encephalopathy (HP:0006846)	1.86042506
90	Sloping forehead (HP:0000340)	1.85813496
91	Abnormality of the labia minora (HP:0012880)	1.80903498
92	Gaze-evoked nystagmus (HP:0000640)	1.80818745
93	Retinitis pigmentosa (HP:0000510)	1.80537556
94	Acute necrotizing encephalopathy (HP:0006965)	1.79972410
95	Meckel diverticulum (HP:0002245)	1.79556927
96	Occipital encephalocele (HP:0002085)	1.74697163
97	Poor coordination (HP:0002370)	1.73866969
98	Hepatocellular necrosis (HP:0001404)	1.73405264
99	Mesangial abnormality (HP:0001966)	1.73346981
100	Methylmalonic aciduria (HP:0012120)	1.73339989

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.71831336
2	MAP4K2	3.15878934
3	ADRBK2	2.98526483
4	MST4	2.78367361
5	ZAK	2.69341248
6	INSRR	2.65885383
7	TRIM28	2.64503742
8	BMPR1B	2.63603838
9	BCKDK	2.26409580
10	NUAK1	2.21847124
11	ACVR1B	2.17302557
12	GRK1	1.96235639
13	TXK	1.94625415
14	EIF2AK3	1.90918958
15	TNIK	1.85040928
16	TAOK3	1.76021505
17	PINK1	1.75302870
18	MAPKAPK3	1.62876077
19	OXSR1	1.51123602
20	TLK1	1.49116929
21	WNK3	1.45937492
22	MAPK13	1.41690658
23	PLK2	1.39388722
24	STK39	1.38981019
25	MUSK	1.35657240
26	STK38L	1.27508253
27	BRSK2	1.24149533
28	PRKCE	1.20738273
29	ADRBK1	1.18571845
30	FER	1.12106888
31	BCR	1.10892527
32	WNK4	1.09450314
33	MAP3K12	1.09061686
34	FES	1.06388460
35	STK16	1.00667067
36	MKNK2	0.98068467
37	VRK1	0.96141930
38	STK3	0.92043184
39	ERBB3	0.91249897
40	PRKCI	0.88229303
41	IKBKB	0.88130128
42	NLK	0.86316099
43	CAMKK2	0.86074730
44	PRKCQ	0.85876912
45	IRAK1	0.85405985
46	PNCK	0.82638619
47	MAP3K4	0.82509605
48	TEC	0.80125719
49	WEE1	0.78885069
50	PLK3	0.78255006
51	CDC7	0.74678206
52	PHKG2	0.73522041
53	PHKG1	0.73522041
54	CSNK1G1	0.72993880
55	MAPKAPK5	0.72875453
56	CSNK1G2	0.72572474
57	CLK1	0.69978914
58	PBK	0.67372969
59	PLK1	0.66642862
60	BMPR2	0.66490621
61	TTK	0.66322269
62	CHEK2	0.66139220
63	CSNK1G3	0.64575386
64	CASK	0.61214661
65	EIF2AK2	0.60822268
66	IKBKE	0.60785247
67	PLK4	0.59597898
68	PRKCG	0.59277932
69	ATR	0.57098149
70	NEK6	0.55393831
71	PDK2	0.54166696
72	TGFBR1	0.54018587
73	GRK5	0.51666167
74	PAK3	0.48967116
75	CHUK	0.47289377
76	MKNK1	0.47217820
77	PRKACA	0.46578551
78	TNK2	0.45693554
79	MARK1	0.45355596
80	GRK7	0.45215616
81	CAMK1	0.44695471
82	PTK2B	0.44082465
83	CSNK1A1L	0.43618391
84	CSNK1D	0.43162319
85	TIE1	0.42682469
86	FGFR2	0.42574343
87	NTRK2	0.41121434
88	ITK	0.40889722
89	DAPK2	0.40251205
90	CAMK2A	0.39075462
91	FLT3	0.39017070
92	RPS6KA4	0.38688777
93	MARK3	0.38657973
94	NTRK3	0.38625066
95	ATM	0.38499456
96	KIT	0.37769597
97	SYK	0.36986032
98	PRKG1	0.35183638
99	PKN1	0.33013248
100	PRKCA	0.32930156

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.41857994
2	Phototransduction_Homo sapiens_hsa04744	3.10037558
3	Homologous recombination_Homo sapiens_hsa03440	2.77156236
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.74314385
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45515301
6	Protein export_Homo sapiens_hsa03060	2.22204314
7	Butanoate metabolism_Homo sapiens_hsa00650	2.18799866
8	Basal transcription factors_Homo sapiens_hsa03022	2.16873597
9	Proteasome_Homo sapiens_hsa03050	2.10011301
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.08654645
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.07139644
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.05057655
13	RNA polymerase_Homo sapiens_hsa03020	2.04268846
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00921946
15	Propanoate metabolism_Homo sapiens_hsa00640	1.90450246
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89751061
17	Caffeine metabolism_Homo sapiens_hsa00232	1.85793275
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84629621
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79479428
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76536864
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67013009
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64931405
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62949156
24	RNA degradation_Homo sapiens_hsa03018	1.62194219
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61199398
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.54214926
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.51627335
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48687036
29	Olfactory transduction_Homo sapiens_hsa04740	1.39125904
30	Parkinsons disease_Homo sapiens_hsa05012	1.37876621
31	One carbon pool by folate_Homo sapiens_hsa00670	1.37183121
32	Regulation of autophagy_Homo sapiens_hsa04140	1.34080908
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.31774484
34	Taste transduction_Homo sapiens_hsa04742	1.31145043
35	ABC transporters_Homo sapiens_hsa02010	1.29836396
36	Peroxisome_Homo sapiens_hsa04146	1.15150408
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.13425358
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10052675
39	Nicotine addiction_Homo sapiens_hsa05033	1.08801861
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.07667959
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05566866
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05419492
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04964835
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00330554
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.96716965
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95601790
47	Retinol metabolism_Homo sapiens_hsa00830	0.95334275
48	Huntingtons disease_Homo sapiens_hsa05016	0.91639855
49	Purine metabolism_Homo sapiens_hsa00230	0.90123083
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89297117
51	Mismatch repair_Homo sapiens_hsa03430	0.85218060
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84790729
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82449912
54	Base excision repair_Homo sapiens_hsa03410	0.82193327
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82044393
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81179860
57	Morphine addiction_Homo sapiens_hsa05032	0.79429433
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76566532
59	RNA transport_Homo sapiens_hsa03013	0.75241701
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73499684
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69487992
62	Sulfur relay system_Homo sapiens_hsa04122	0.69397319
63	Asthma_Homo sapiens_hsa05310	0.68242072
64	Metabolic pathways_Homo sapiens_hsa01100	0.68191503
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68080748
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67665000
67	Histidine metabolism_Homo sapiens_hsa00340	0.66025020
68	Oocyte meiosis_Homo sapiens_hsa04114	0.65926991
69	Circadian rhythm_Homo sapiens_hsa04710	0.65019489
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64421482
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64158532
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64131530
73	GABAergic synapse_Homo sapiens_hsa04727	0.63889754
74	Serotonergic synapse_Homo sapiens_hsa04726	0.62504322
75	Alzheimers disease_Homo sapiens_hsa05010	0.62150306
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59327375
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54850735
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.53699755
79	Salivary secretion_Homo sapiens_hsa04970	0.53275091
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49746641
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.46271935
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45871367
83	Insulin secretion_Homo sapiens_hsa04911	0.45009012
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44417149
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42953080
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41468418
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.41418828
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41334319
89	Sulfur metabolism_Homo sapiens_hsa00920	0.40742705
90	Allograft rejection_Homo sapiens_hsa05330	0.40404404
91	Circadian entrainment_Homo sapiens_hsa04713	0.39871143
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38803071
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37660427
94	Fatty acid degradation_Homo sapiens_hsa00071	0.37103976
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.34715894
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34333959
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.34022102
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33488256
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.31908134
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30433358

C1ORF146

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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