ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.55693189
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.49837136
3	epithelial cilium movement (GO:0003351)	6.52525104
4	cilium movement (GO:0003341)	6.40944848
5	neuron fate determination (GO:0048664)	6.07783236
6	cysteine metabolic process (GO:0006534)	5.75715200
7	protein-cofactor linkage (GO:0018065)	5.70434972
8	motile cilium assembly (GO:0044458)	5.60770995
9	cilium or flagellum-dependent cell motility (GO:0001539)	5.33905996
10	astrocyte differentiation (GO:0048708)	4.98096470
11	homocysteine metabolic process (GO:0050667)	4.92586201
12	positive regulation of oligodendrocyte differentiation (GO:0048714)	4.80569896
13	axoneme assembly (GO:0035082)	4.71991467
14	cell proliferation in forebrain (GO:0021846)	4.57908478
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.44047508
16	behavioral response to nicotine (GO:0035095)	4.41249799
17	regulation of cilium movement (GO:0003352)	4.26684748
18	response to pheromone (GO:0019236)	4.14893765
19	behavioral response to ethanol (GO:0048149)	4.12538129
20	ventricular system development (GO:0021591)	3.98185830
21	prepulse inhibition (GO:0060134)	3.95580810
22	axon ensheathment in central nervous system (GO:0032291)	3.87969147
23	central nervous system myelination (GO:0022010)	3.87969147
24	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.78940587
25	regulation of oligodendrocyte differentiation (GO:0048713)	3.78542179
26	pattern specification involved in kidney development (GO:0061004)	3.64721625
27	type B pancreatic cell development (GO:0003323)	3.64637486
28	negative regulation of astrocyte differentiation (GO:0048712)	3.60291147
29	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.49705836
30	cilium organization (GO:0044782)	3.47654912
31	proline transport (GO:0015824)	3.43139976
32	neuronal stem cell maintenance (GO:0097150)	3.40578796
33	cilium assembly (GO:0042384)	3.38198796
34	alanine transport (GO:0032328)	3.36388015
35	positive regulation of vascular permeability (GO:0043117)	3.33615789
36	nephron epithelium morphogenesis (GO:0072088)	3.27288567
37	nephron tubule morphogenesis (GO:0072078)	3.27288567
38	spinal cord motor neuron differentiation (GO:0021522)	3.24779899
39	sperm motility (GO:0030317)	3.23781617
40	adaptation of signaling pathway (GO:0023058)	3.23489465
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.22050516
42	centriole replication (GO:0007099)	3.16427552
43	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.15077360
44	startle response (GO:0001964)	3.10512246
45	L-fucose catabolic process (GO:0042355)	3.04703055
46	fucose catabolic process (GO:0019317)	3.04703055
47	L-fucose metabolic process (GO:0042354)	3.04703055
48	cilium morphogenesis (GO:0060271)	3.03794508
49	nucleoside diphosphate phosphorylation (GO:0006165)	3.00964260
50	gamma-aminobutyric acid transport (GO:0015812)	3.00453004
51	intra-S DNA damage checkpoint (GO:0031573)	2.99711327
52	epithelial cell fate commitment (GO:0072148)	2.95917420
53	negative regulation of glial cell differentiation (GO:0045686)	2.95788379
54	regulation of microtubule-based movement (GO:0060632)	2.93693412
55	smoothened signaling pathway (GO:0007224)	2.92389058
56	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.91958608
57	negative regulation of T cell differentiation in thymus (GO:0033085)	2.91777309
58	cranial nerve development (GO:0021545)	2.87251800
59	negative regulation of telomere maintenance (GO:0032205)	2.86873020
60	piRNA metabolic process (GO:0034587)	2.86643106
61	retinal rod cell development (GO:0046548)	2.84783300
62	forebrain neuron differentiation (GO:0021879)	2.82082955
63	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.81590571
64	sulfur amino acid catabolic process (GO:0000098)	2.80175084
65	neuronal action potential (GO:0019228)	2.77535441
66	sphingoid metabolic process (GO:0046519)	2.76111456
67	positive regulation of glial cell differentiation (GO:0045687)	2.75337246
68	diol metabolic process (GO:0034311)	2.74923932
69	intraciliary transport (GO:0042073)	2.67087151
70	neuron fate specification (GO:0048665)	2.64734390
71	retinal cone cell development (GO:0046549)	2.64159297
72	endocrine pancreas development (GO:0031018)	2.63997687
73	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63982311
74	left/right axis specification (GO:0070986)	2.60389819
75	NAD biosynthetic process (GO:0009435)	2.60127961
76	cellular component assembly involved in morphogenesis (GO:0010927)	2.59627957
77	photoreceptor cell development (GO:0042461)	2.57394620
78	centriole assembly (GO:0098534)	2.56489652
79	exogenous drug catabolic process (GO:0042738)	2.51165170
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.46597874
81	pituitary gland development (GO:0021983)	2.45736844
82	photoreceptor cell maintenance (GO:0045494)	2.45570787
83	detection of light stimulus involved in visual perception (GO:0050908)	2.44815423
84	detection of light stimulus involved in sensory perception (GO:0050962)	2.44815423
85	vitamin transmembrane transport (GO:0035461)	2.42276080
86	regulation of glial cell differentiation (GO:0045685)	2.39600148
87	regulation of action potential (GO:0098900)	2.37815908
88	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.37029042
89	L-phenylalanine catabolic process (GO:0006559)	2.37029042
90	tongue development (GO:0043586)	2.36570110
91	regulation of neurotransmitter uptake (GO:0051580)	2.34923707
92	glutathione derivative metabolic process (GO:1901685)	2.34079495
93	glutathione derivative biosynthetic process (GO:1901687)	2.34079495
94	melanosome transport (GO:0032402)	2.32689524
95	determination of left/right symmetry (GO:0007368)	2.32057993
96	labyrinthine layer development (GO:0060711)	2.30428359
97	renal tubule morphogenesis (GO:0061333)	2.30248877
98	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.29568395
99	ovulation cycle (GO:0042698)	2.29196184
100	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.29122966

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.97951917
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.38818536
3	VDR_22108803_ChIP-Seq_LS180_Human	3.09071517
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.76466950
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.69361343
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.67419554
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59391722
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53365855
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.52899010
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33104160
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27753256
12	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24921988
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14006408
14	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.99110821
15	FUS_26573619_Chip-Seq_HEK293_Human	1.90793251
16	P300_19829295_ChIP-Seq_ESCs_Human	1.80753533
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79834163
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.77348622
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.76791304
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74375760
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66894888
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.66624678
23	EWS_26573619_Chip-Seq_HEK293_Human	1.66098909
24	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61308035
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61040958
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.60421242
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59785006
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.59453527
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57240473
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55674914
31	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.54716433
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51284090
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50836226
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.48899380
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48707933
36	AR_25329375_ChIP-Seq_VCAP_Human	1.46243918
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46100760
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.45401552
39	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44053107
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43348030
41	STAT3_23295773_ChIP-Seq_U87_Human	1.42313532
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42236881
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40351908
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.40096773
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39877169
46	TCF4_23295773_ChIP-Seq_U87_Human	1.39266500
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37886864
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.36688478
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36670844
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36304536
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.36304536
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35471610
53	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.34642466
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.33394522
55	DROSHA_22980978_ChIP-Seq_HELA_Human	1.31310234
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27977684
57	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27572855
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26578310
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25767031
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25228321
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24091352
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22071077
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20786204
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20786204
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19129440
66	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18283338
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17106025
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17106025
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16878481
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16878481
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16813083
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15870860
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15605062
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14426095
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12567803
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12449447
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10609223
78	NCOR_22424771_ChIP-Seq_293T_Human	1.10573687
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10196046
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09212388
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08960552
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.08747383
83	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08290273
84	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08183396
85	AR_20517297_ChIP-Seq_VCAP_Human	1.05963648
86	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.05419456
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05055709
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04265071
89	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02619554
90	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.01541847
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00918320
92	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00298093
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.00012684
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99071865
95	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98828983
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98610140
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97992840
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97585733
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96690744
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96461175

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.28456942
2	MP0002653_abnormal_ependyma_morphology	3.42900591
3	MP0002638_abnormal_pupillary_reflex	3.37996132
4	MP0004043_abnormal_pH_regulation	2.88618225
5	MP0010234_abnormal_vibrissa_follicle	2.82001288
6	MP0005551_abnormal_eye_electrophysiolog	2.43523074
7	MP0003195_calcinosis	2.25388583
8	MP0002837_dystrophic_cardiac_calcinosis	2.20199922
9	MP0004885_abnormal_endolymph	2.15234868
10	MP0008877_abnormal_DNA_methylation	2.13165474
11	MP0008875_abnormal_xenobiotic_pharmacok	2.07737482
12	MP0005451_abnormal_body_composition	2.06853571
13	MP0001485_abnormal_pinna_reflex	2.03300409
14	MP0004142_abnormal_muscle_tone	2.02978540
15	MP0005646_abnormal_pituitary_gland	1.95831900
16	MP0005408_hypopigmentation	1.91242534
17	MP0002277_abnormal_respiratory_mucosa	1.87613508
18	MP0003878_abnormal_ear_physiology	1.86107543
19	MP0005377_hearing/vestibular/ear_phenot	1.86107543
20	MP0003787_abnormal_imprinting	1.83597887
21	MP0009745_abnormal_behavioral_response	1.82645154
22	MP0003646_muscle_fatigue	1.73658057
23	MP0000631_abnormal_neuroendocrine_gland	1.70226031
24	MP0005084_abnormal_gallbladder_morpholo	1.70021959
25	MP0001984_abnormal_olfaction	1.66389318
26	MP0000569_abnormal_digit_pigmentation	1.63717167
27	MP0005253_abnormal_eye_physiology	1.58218737
28	MP0009046_muscle_twitch	1.56246019
29	MP0001968_abnormal_touch/_nociception	1.53197785
30	MP0002272_abnormal_nervous_system	1.49811627
31	MP0004742_abnormal_vestibular_system	1.47640815
32	MP0002572_abnormal_emotion/affect_behav	1.43892946
33	MP0000026_abnormal_inner_ear	1.43477951
34	MP0002938_white_spotting	1.42226277
35	MP0005645_abnormal_hypothalamus_physiol	1.41687853
36	MP0002928_abnormal_bile_duct	1.41391010
37	MP0006072_abnormal_retinal_apoptosis	1.39138667
38	MP0004133_heterotaxia	1.36225212
39	MP0000372_irregular_coat_pigmentation	1.31016223
40	MP0002067_abnormal_sensory_capabilities	1.28910294
41	MP0010678_abnormal_skin_adnexa	1.28544888
42	MP0003718_maternal_effect	1.27567989
43	MP0003880_abnormal_central_pattern	1.27122320
44	MP0003011_delayed_dark_adaptation	1.24083012
45	MP0002249_abnormal_larynx_morphology	1.23842766
46	MP0008872_abnormal_physiological_respon	1.21730134
47	MP0001986_abnormal_taste_sensitivity	1.21257238
48	MP0003122_maternal_imprinting	1.20182389
49	MP0002557_abnormal_social/conspecific_i	1.19967479
50	MP0001486_abnormal_startle_reflex	1.19759170
51	MP0001502_abnormal_circadian_rhythm	1.17191100
52	MP0001970_abnormal_pain_threshold	1.16635329
53	MP0002102_abnormal_ear_morphology	1.14513590
54	MP0001501_abnormal_sleep_pattern	1.14481944
55	MP0002063_abnormal_learning/memory/cond	1.12412362
56	MP0000049_abnormal_middle_ear	1.12234875
57	MP0002735_abnormal_chemical_nociception	1.11797052
58	MP0002064_seizures	1.11239925
59	MP0005174_abnormal_tail_pigmentation	1.10756552
60	MP0003635_abnormal_synaptic_transmissio	1.10132082
61	MP0001764_abnormal_homeostasis	1.09370201
62	MP0005423_abnormal_somatic_nervous	1.08430041
63	MP0000955_abnormal_spinal_cord	1.08353073
64	MP0005171_absent_coat_pigmentation	1.07840021
65	MP0001905_abnormal_dopamine_level	1.07445148
66	MP0005195_abnormal_posterior_eye	1.04500376
67	MP0003638_abnormal_response/metabolism_	1.04483210
68	MP0004215_abnormal_myocardial_fiber	0.99738456
69	MP0005332_abnormal_amino_acid	0.99413313
70	MP0002282_abnormal_trachea_morphology	0.99010802
71	MP0001963_abnormal_hearing_physiology	0.96692469
72	MP0000778_abnormal_nervous_system	0.95857901
73	MP0001324_abnormal_eye_pigmentation	0.95537688
74	MP0002736_abnormal_nociception_after	0.94715194
75	MP0006276_abnormal_autonomic_nervous	0.93121346
76	MP0002876_abnormal_thyroid_physiology	0.92985446
77	MP0003186_abnormal_redox_activity	0.92766907
78	MP0002733_abnormal_thermal_nociception	0.91924219
79	MP0002229_neurodegeneration	0.91160285
80	MP0002909_abnormal_adrenal_gland	0.89846918
81	MP0006292_abnormal_olfactory_placode	0.88333528
82	MP0003890_abnormal_embryonic-extraembry	0.88053743
83	MP0005083_abnormal_biliary_tract	0.83597675
84	MP0002090_abnormal_vision	0.83137538
85	MP0002234_abnormal_pharynx_morphology	0.82317490
86	MP0003137_abnormal_impulse_conducting	0.82174678
87	MP0004085_abnormal_heartbeat	0.80164930
88	MP0000230_abnormal_systemic_arterial	0.79810162
89	MP0004147_increased_porphyrin_level	0.79297165
90	MP0005389_reproductive_system_phenotype	0.78924170
91	MP0004924_abnormal_behavior	0.78919303
92	MP0005386_behavior/neurological_phenoty	0.78919303
93	MP0002752_abnormal_somatic_nervous	0.78235255
94	MP0004019_abnormal_vitamin_homeostasis	0.77828517
95	MP0005167_abnormal_blood-brain_barrier	0.77624973
96	MP0001944_abnormal_pancreas_morphology	0.77185305
97	MP0002734_abnormal_mechanical_nocicepti	0.75897040
98	MP0000383_abnormal_hair_follicle	0.75681622
99	MP0008058_abnormal_DNA_repair	0.74936749
100	MP0003698_abnormal_male_reproductive	0.73724851

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.08239680
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.31974408
3	Absent/shortened dynein arms (HP:0200106)	6.31974408
4	Abnormal respiratory epithelium morphology (HP:0012253)	6.01925190
5	Abnormal respiratory motile cilium morphology (HP:0005938)	6.01925190
6	Abnormal ciliary motility (HP:0012262)	5.52367492
7	Abnormal respiratory motile cilium physiology (HP:0012261)	5.50330071
8	Pancreatic fibrosis (HP:0100732)	5.02206405
9	True hermaphroditism (HP:0010459)	4.99648901
10	Rhinitis (HP:0012384)	4.92307421
11	Pancreatic cysts (HP:0001737)	4.59732417
12	Chronic bronchitis (HP:0004469)	4.48334591
13	Abnormality of midbrain morphology (HP:0002418)	4.33478528
14	Molar tooth sign on MRI (HP:0002419)	4.33478528
15	Nephronophthisis (HP:0000090)	4.29331908
16	Abnormality of the renal medulla (HP:0100957)	3.44343115
17	Bronchiectasis (HP:0002110)	3.29369963
18	Pheochromocytoma (HP:0002666)	3.24576677
19	Cystic liver disease (HP:0006706)	3.19296800
20	Tubular atrophy (HP:0000092)	3.14765334
21	Furrowed tongue (HP:0000221)	3.10869819
22	Chronic hepatic failure (HP:0100626)	3.05822072
23	Neuroendocrine neoplasm (HP:0100634)	2.98319108
24	Type II lissencephaly (HP:0007260)	2.95779035
25	Sclerocornea (HP:0000647)	2.91251317
26	Abdominal situs inversus (HP:0003363)	2.89884262
27	Abnormality of abdominal situs (HP:0011620)	2.89884262
28	Rib fusion (HP:0000902)	2.79779259
29	Occipital encephalocele (HP:0002085)	2.78674844
30	Medial flaring of the eyebrow (HP:0010747)	2.76362692
31	Congenital stationary night blindness (HP:0007642)	2.70919500
32	Nasal polyposis (HP:0100582)	2.69712110
33	Hyperventilation (HP:0002883)	2.67138145
34	Abnormality of the renal cortex (HP:0011035)	2.64481661
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.61651305
36	Recurrent sinusitis (HP:0011108)	2.59726714
37	Adrenal hypoplasia (HP:0000835)	2.54354915
38	Abolished electroretinogram (ERG) (HP:0000550)	2.52681834
39	Polydipsia (HP:0001959)	2.48172312
40	Abnormal drinking behavior (HP:0030082)	2.48172312
41	Conjunctival hamartoma (HP:0100780)	2.44661784
42	Congenital hepatic fibrosis (HP:0002612)	2.39736820
43	Large for gestational age (HP:0001520)	2.35744713
44	Anencephaly (HP:0002323)	2.32597618
45	Optic nerve hypoplasia (HP:0000609)	2.28520256
46	Male pseudohermaphroditism (HP:0000037)	2.26914766
47	Postaxial foot polydactyly (HP:0001830)	2.23561138
48	Gait imbalance (HP:0002141)	2.14299824
49	Congenital primary aphakia (HP:0007707)	2.13948429
50	Progressive cerebellar ataxia (HP:0002073)	2.12197803
51	Methylmalonic acidemia (HP:0002912)	2.12129178
52	Decreased central vision (HP:0007663)	2.12062915
53	Septo-optic dysplasia (HP:0100842)	2.09192308
54	Bronchitis (HP:0012387)	2.07461498
55	Pendular nystagmus (HP:0012043)	2.06756552
56	Gastrointestinal atresia (HP:0002589)	2.06338816
57	Action tremor (HP:0002345)	2.06163463
58	Keratoconus (HP:0000563)	2.03981121
59	Increased corneal curvature (HP:0100692)	2.03981121
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03828010
61	Abnormality of the nasal mucosa (HP:0000433)	2.01191992
62	Hamartoma of the eye (HP:0010568)	1.99091220
63	Chorioretinal atrophy (HP:0000533)	1.96876226
64	Abnormality of the diencephalon (HP:0010662)	1.94481040
65	Hemiparesis (HP:0001269)	1.93349149
66	Anophthalmia (HP:0000528)	1.88810678
67	Polyuria (HP:0000103)	1.87200891
68	Genital tract atresia (HP:0001827)	1.86731677
69	Nephrogenic diabetes insipidus (HP:0009806)	1.86152021
70	Abnormal rod and cone electroretinograms (HP:0008323)	1.83050923
71	Postaxial hand polydactyly (HP:0001162)	1.83000145
72	Tubulointerstitial nephritis (HP:0001970)	1.82012898
73	Retinal dysplasia (HP:0007973)	1.80930527
74	Attenuation of retinal blood vessels (HP:0007843)	1.79011570
75	Preaxial hand polydactyly (HP:0001177)	1.78342904
76	Esophageal atresia (HP:0002032)	1.76698129
77	Tinnitus (HP:0000360)	1.76144777
78	Acute necrotizing encephalopathy (HP:0006965)	1.74169674
79	Infertility (HP:0000789)	1.72729745
80	Narrow forehead (HP:0000341)	1.71046203
81	Abnormality of macular pigmentation (HP:0008002)	1.69196754
82	Polyphagia (HP:0002591)	1.68917031
83	Gaze-evoked nystagmus (HP:0000640)	1.68589420
84	Bile duct proliferation (HP:0001408)	1.67389858
85	Abnormal biliary tract physiology (HP:0012439)	1.67389858
86	Lissencephaly (HP:0001339)	1.66835909
87	Vaginal atresia (HP:0000148)	1.65341929
88	Neoplasm of the peripheral nervous system (HP:0100007)	1.63877861
89	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.62994747
90	Esophageal neoplasm (HP:0100751)	1.62891284
91	Neoplasm of head and neck (HP:0012288)	1.62891284
92	Bone cyst (HP:0012062)	1.62270589
93	Oculomotor apraxia (HP:0000657)	1.62138581
94	Neoplasm of the adrenal gland (HP:0100631)	1.61611479
95	Myokymia (HP:0002411)	1.60673192
96	Intestinal atresia (HP:0011100)	1.60660455
97	Congenital, generalized hypertrichosis (HP:0004540)	1.59914730
98	Mitochondrial inheritance (HP:0001427)	1.59209896
99	Abnormality of the vocal cords (HP:0008777)	1.59057311
100	Tachypnea (HP:0002789)	1.57583623

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.95031895
2	MAP3K9	5.35848024
3	ARAF	4.88461811
4	MAP3K13	4.88180379
5	MAPK15	3.30790349
6	FRK	2.87860148
7	BMPR1B	2.70172250
8	TAOK3	2.63198342
9	WEE1	2.59225855
10	MOS	2.45514510
11	LIMK1	2.32495316
12	ADRBK2	2.19583663
13	VRK2	2.07307510
14	BRAF	1.97606778
15	NTRK3	1.84566074
16	KSR2	1.63467330
17	MAP4K2	1.56235618
18	EPHA3	1.53625462
19	NTRK2	1.50829753
20	GRK1	1.31793709
21	WNK3	1.29919917
22	VRK1	1.27033292
23	PAK2	1.21789399
24	PTK2B	1.16645504
25	EPHA4	1.15698996
26	TSSK6	1.13250753
27	WNK4	1.08720768
28	INSRR	1.05079297
29	PINK1	1.04803127
30	PRKCG	1.04256492
31	STK16	1.03402179
32	RAF1	1.01467388
33	MAPK13	0.94774814
34	KSR1	0.90940956
35	ACVR1B	0.89523689
36	ZAK	0.84952096
37	OXSR1	0.82532425
38	CDC42BPA	0.81385235
39	NUAK1	0.75668116
40	MAP3K4	0.75182433
41	AKT3	0.73912270
42	TLK1	0.69814165
43	STK38L	0.69238066
44	STK39	0.65305150
45	TGFBR1	0.62648711
46	FLT3	0.60918905
47	ADRBK1	0.59427787
48	MAPKAPK5	0.59107242
49	PHKG1	0.57908815
50	PHKG2	0.57908815
51	CASK	0.57706122
52	TXK	0.55956182
53	PRKCE	0.55101339
54	PLK2	0.54121249
55	MAPKAPK3	0.52466664
56	MAP2K1	0.51079241
57	BRSK2	0.46048368
58	CSNK1G2	0.45284151
59	MST4	0.44405889
60	PLK4	0.44150054
61	CSNK1G1	0.42899953
62	TNIK	0.42879978
63	CSNK1G3	0.40952165
64	PAK3	0.40689248
65	ROCK2	0.40659891
66	DAPK2	0.40325176
67	ROCK1	0.40069722
68	CDK3	0.36141921
69	MUSK	0.35525120
70	CAMKK2	0.34667257
71	DYRK2	0.34231882
72	TNK2	0.33229762
73	SGK2	0.30625671
74	CAMK2A	0.28904186
75	FGFR2	0.28901700
76	CSNK1A1L	0.27944128
77	PRKACB	0.27898291
78	PRKCQ	0.26048243
79	MKNK2	0.25100181
80	GRK5	0.24067658
81	IRAK1	0.23018070
82	PRKACA	0.22279718
83	MARK1	0.21977261
84	TIE1	0.21021057
85	MAP2K7	0.20478605
86	MET	0.20213725
87	CSNK1A1	0.19904789
88	PRKCH	0.18832337
89	NTRK1	0.18622529
90	GRK7	0.18211324
91	IGF1R	0.16752978
92	PKN1	0.16643659
93	PLK3	0.16187676
94	PAK1	0.15875897
95	PRKCA	0.15685116
96	STK38	0.13395018
97	OBSCN	0.13072544
98	CDK19	0.12831961
99	PRKAA1	0.12809098
100	PRKG1	0.12055981

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.06144245
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.55977591
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.00304085
4	Phototransduction_Homo sapiens_hsa04744	2.96661401
5	Nicotine addiction_Homo sapiens_hsa05033	2.38054043
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.31883035
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.14221281
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08693386
9	Protein export_Homo sapiens_hsa03060	2.03237609
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01470595
11	Chemical carcinogenesis_Homo sapiens_hsa05204	1.96699335
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.88667150
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88013804
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85535606
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.76775886
16	Parkinsons disease_Homo sapiens_hsa05012	1.66868222
17	Butanoate metabolism_Homo sapiens_hsa00650	1.64867899
18	Caffeine metabolism_Homo sapiens_hsa00232	1.56184056
19	Propanoate metabolism_Homo sapiens_hsa00640	1.54241305
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53872980
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.52113948
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50652170
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.41301222
24	Tyrosine metabolism_Homo sapiens_hsa00350	1.41189596
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.33609532
26	Olfactory transduction_Homo sapiens_hsa04740	1.32605211
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.32587247
28	Huntingtons disease_Homo sapiens_hsa05016	1.31990440
29	Sulfur relay system_Homo sapiens_hsa04122	1.30779380
30	Morphine addiction_Homo sapiens_hsa05032	1.29767715
31	Retinol metabolism_Homo sapiens_hsa00830	1.23896747
32	Homologous recombination_Homo sapiens_hsa03440	1.22578574
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21450569
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20437456
35	GABAergic synapse_Homo sapiens_hsa04727	1.16692616
36	Taste transduction_Homo sapiens_hsa04742	1.12335298
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11625820
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10808368
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06533286
40	Serotonergic synapse_Homo sapiens_hsa04726	1.06173946
41	Insulin secretion_Homo sapiens_hsa04911	1.03976086
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03693889
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03557192
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03527076
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02238727
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.01449180
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96832575
48	RNA polymerase_Homo sapiens_hsa03020	0.95182190
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.95122585
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.94895408
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.93062658
52	Alzheimers disease_Homo sapiens_hsa05010	0.88445128
53	ABC transporters_Homo sapiens_hsa02010	0.85116553
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85039271
55	Circadian entrainment_Homo sapiens_hsa04713	0.84381377
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81600377
57	Peroxisome_Homo sapiens_hsa04146	0.80475233
58	Salivary secretion_Homo sapiens_hsa04970	0.80048413
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77821938
60	Folate biosynthesis_Homo sapiens_hsa00790	0.77308712
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76503855
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.73217104
63	RNA degradation_Homo sapiens_hsa03018	0.69417628
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69217617
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68323322
66	Metabolic pathways_Homo sapiens_hsa01100	0.68023532
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67902652
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67433793
69	Circadian rhythm_Homo sapiens_hsa04710	0.67253914
70	Cocaine addiction_Homo sapiens_hsa05030	0.66677527
71	Basal transcription factors_Homo sapiens_hsa03022	0.66034470
72	Histidine metabolism_Homo sapiens_hsa00340	0.65943347
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64741442
74	Purine metabolism_Homo sapiens_hsa00230	0.62769980
75	Long-term depression_Homo sapiens_hsa04730	0.62680292
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.62529852
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.62011111
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60727784
79	Amphetamine addiction_Homo sapiens_hsa05031	0.59822377
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59658583
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58849032
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56743516
83	Glutathione metabolism_Homo sapiens_hsa00480	0.56219983
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52844280
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.51602221
86	Ribosome_Homo sapiens_hsa03010	0.50548075
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50529566
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46710051
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.46042679
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.44650589
91	Regulation of autophagy_Homo sapiens_hsa04140	0.44637843
92	Cholinergic synapse_Homo sapiens_hsa04725	0.43993842
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41156243
94	Axon guidance_Homo sapiens_hsa04360	0.40927278
95	Sulfur metabolism_Homo sapiens_hsa00920	0.40443009
96	Fatty acid degradation_Homo sapiens_hsa00071	0.35847508
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35629380
98	Asthma_Homo sapiens_hsa05310	0.32623727
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31621024
100	Gastric acid secretion_Homo sapiens_hsa04971	0.29342546

C1ORF158

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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