

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neutrophil activation involved in immune response (GO:0002283) | 6.61868816 |
| 2 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.56396145 |
| 3 | immunoglobulin mediated immune response (GO:0016064) | 5.26339254 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.15261157 |
| 5 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.88559816 |
| 6 | negative regulation of cell killing (GO:0031342) | 4.88559816 |
| 7 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.84987571 |
| 8 | positive regulation of mast cell activation (GO:0033005) | 4.81544130 |
| 9 | positive regulation of mast cell degranulation (GO:0043306) | 4.77573026 |
| 10 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 4.77573026 |
| 11 | response to peptidoglycan (GO:0032494) | 4.74877271 |
| 12 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.73957215 |
| 13 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.73957215 |
| 14 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.73957215 |
| 15 | modulation by symbiont of host immune response (GO:0052553) | 4.73957215 |
| 16 | positive regulation by symbiont of host defense response (GO:0052509) | 4.73957215 |
| 17 | modulation by symbiont of host defense response (GO:0052031) | 4.73957215 |
| 18 | macrophage activation involved in immune response (GO:0002281) | 4.66771510 |
| 19 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.61823041 |
| 20 | detection of other organism (GO:0098543) | 4.54133586 |
| 21 | detection of bacterium (GO:0016045) | 4.48220105 |
| 22 | regulation of mast cell degranulation (GO:0043304) | 4.41998162 |
| 23 | neutrophil activation (GO:0042119) | 4.32117200 |
| 24 | microglial cell activation (GO:0001774) | 4.17980636 |
| 25 | B cell mediated immunity (GO:0019724) | 4.12726301 |
| 26 | interferon-gamma-mediated signaling pathway (GO:0060333) | 4.10251768 |
| 27 | regulation of mast cell activation involved in immune response (GO:0033006) | 4.07709919 |
| 28 | myeloid cell activation involved in immune response (GO:0002275) | 4.06022529 |
| 29 | granulocyte activation (GO:0036230) | 4.03561688 |
| 30 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.98887073 |
| 31 | regulation of mast cell activation (GO:0033003) | 3.98842682 |
| 32 | negative regulation of interleukin-12 production (GO:0032695) | 3.97150023 |
| 33 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.90329268 |
| 34 | detection of external biotic stimulus (GO:0098581) | 3.89529481 |
| 35 | regulation of hypersensitivity (GO:0002883) | 3.79744672 |
| 36 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.78077795 |
| 37 | cellular extravasation (GO:0045123) | 3.77380248 |
| 38 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.75977724 |
| 39 | leukocyte aggregation (GO:0070486) | 3.75502210 |
| 40 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.75300912 |
| 41 | regulation of gamma-delta T cell activation (GO:0046643) | 3.67760777 |
| 42 | positive regulation of antigen processing and presentation (GO:0002579) | 3.63848053 |
| 43 | respiratory burst (GO:0045730) | 3.62366615 |
| 44 | positive thymic T cell selection (GO:0045059) | 3.62176141 |
| 45 | macrophage activation (GO:0042116) | 3.60297760 |
| 46 | regulation of T cell tolerance induction (GO:0002664) | 3.59085633 |
| 47 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.57937863 |
| 48 | regulation of antigen processing and presentation (GO:0002577) | 3.57221075 |
| 49 | regulation of tolerance induction (GO:0002643) | 3.56819547 |
| 50 | regulation of leukocyte degranulation (GO:0043300) | 3.56653126 |
| 51 | detection of molecule of bacterial origin (GO:0032490) | 3.55607679 |
| 52 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.51556496 |
| 53 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.47785768 |
| 54 | mast cell activation (GO:0045576) | 3.47267381 |
| 55 | detection of biotic stimulus (GO:0009595) | 3.45708617 |
| 56 | positive regulation of leukocyte degranulation (GO:0043302) | 3.45694541 |
| 57 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.45059091 |
| 58 | defense response to protozoan (GO:0042832) | 3.37350939 |
| 59 | positive regulation of B cell differentiation (GO:0045579) | 3.34260648 |
| 60 | response to host immune response (GO:0052572) | 3.31753004 |
| 61 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.31753004 |
| 62 | B cell receptor signaling pathway (GO:0050853) | 3.26410455 |
| 63 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.25509517 |
| 64 | positive regulation of type 2 immune response (GO:0002830) | 3.24324794 |
| 65 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.23718006 |
| 66 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.23157996 |
| 67 | negative thymic T cell selection (GO:0045060) | 3.18822765 |
| 68 | response to muramyl dipeptide (GO:0032495) | 3.17899556 |
| 69 | cellular response to interferon-gamma (GO:0071346) | 3.17100085 |
| 70 | regulation of B cell differentiation (GO:0045577) | 3.16237790 |
| 71 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.14793471 |
| 72 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.13277320 |
| 73 | leukocyte degranulation (GO:0043299) | 3.12230151 |
| 74 | negative T cell selection (GO:0043383) | 3.10935682 |
| 75 | negative regulation of T cell mediated immunity (GO:0002710) | 3.07232832 |
| 76 | response to protozoan (GO:0001562) | 3.04741102 |
| 77 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.04467469 |
| 78 | T cell costimulation (GO:0031295) | 3.03886736 |
| 79 | regulation of germinal center formation (GO:0002634) | 3.03640372 |
| 80 | lymphocyte costimulation (GO:0031294) | 2.99656454 |
| 81 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.99303622 |
| 82 | myeloid leukocyte activation (GO:0002274) | 2.98361398 |
| 83 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.97620638 |
| 84 | cellular response to type I interferon (GO:0071357) | 2.96966269 |
| 85 | type I interferon signaling pathway (GO:0060337) | 2.96966269 |
| 86 | regulation of regulated secretory pathway (GO:1903305) | 2.96685454 |
| 87 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.96095852 |
| 88 | response to interferon-gamma (GO:0034341) | 2.95462250 |
| 89 | response to type I interferon (GO:0034340) | 2.93325322 |
| 90 | neutrophil mediated immunity (GO:0002446) | 2.92406033 |
| 91 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.91772331 |
| 92 | positive T cell selection (GO:0043368) | 2.91695920 |
| 93 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.91675294 |
| 94 | response to host (GO:0075136) | 2.91675294 |
| 95 | response to host defenses (GO:0052200) | 2.91675294 |
| 96 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.91520709 |
| 97 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.90469168 |
| 98 | positive regulation of regulated secretory pathway (GO:1903307) | 2.84643728 |
| 99 | myeloid dendritic cell activation (GO:0001773) | 2.83212346 |
| 100 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.83139507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.61424606 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 5.21246858 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.19670034 |
| 4 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.71256260 |
| 5 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.55624530 |
| 6 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.46190300 |
| 7 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.44553600 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.27440143 |
| 9 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.25638848 |
| 10 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.15518686 |
| 11 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.95251841 |
| 12 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.82802736 |
| 13 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.77764079 |
| 14 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.76110498 |
| 15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.73973362 |
| 16 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.62640705 |
| 17 | MYB_26560356_Chip-Seq_TH2_Human | 2.57868433 |
| 18 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.57842929 |
| 19 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.55504107 |
| 20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.50404791 |
| 21 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.47031842 |
| 22 | SPI1_23127762_ChIP-Seq_K562_Human | 2.42593159 |
| 23 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.35098341 |
| 24 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.28241892 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.27707123 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.23205637 |
| 27 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.04973896 |
| 28 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.04216113 |
| 29 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.03492952 |
| 30 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.01118023 |
| 31 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.00684295 |
| 32 | * MAF_26560356_Chip-Seq_TH1_Human | 1.95953543 |
| 33 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.93982808 |
| 34 | MYB_26560356_Chip-Seq_TH1_Human | 1.91586167 |
| 35 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.86286872 |
| 36 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.85716098 |
| 37 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.79790500 |
| 38 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76744741 |
| 39 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.75781317 |
| 40 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.75361087 |
| 41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69950963 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.69046185 |
| 43 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.68172839 |
| 44 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.66356847 |
| 45 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.58175309 |
| 46 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.53801897 |
| 47 | MYC_22102868_ChIP-Seq_BL_Human | 1.52379828 |
| 48 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.47692158 |
| 49 | * MAF_26560356_Chip-Seq_TH2_Human | 1.42744910 |
| 50 | GATA1_22025678_ChIP-Seq_K562_Human | 1.36038442 |
| 51 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.35569968 |
| 52 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.34058980 |
| 53 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.33788017 |
| 54 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.31787764 |
| 55 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.29844443 |
| 56 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.29098283 |
| 57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.28645604 |
| 58 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.28396940 |
| 59 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.28324127 |
| 60 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.25364069 |
| 61 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.24346475 |
| 62 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.23572498 |
| 63 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.21864388 |
| 64 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.19032296 |
| 65 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.13460129 |
| 66 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.09330952 |
| 67 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08388171 |
| 68 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.08225426 |
| 69 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.06318889 |
| 70 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.06164978 |
| 71 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.05233078 |
| 72 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.03808246 |
| 73 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.01512798 |
| 74 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.00253532 |
| 75 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99368226 |
| 76 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.98993596 |
| 77 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.97985712 |
| 78 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.97052268 |
| 79 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.95074050 |
| 80 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93922269 |
| 81 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92951676 |
| 82 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.92781259 |
| 83 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92704968 |
| 84 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.91232459 |
| 85 | GATA1_19941826_ChIP-Seq_K562_Human | 0.90920697 |
| 86 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.90290253 |
| 87 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.89670934 |
| 88 | P300_27268052_Chip-Seq_Bcells_Human | 0.88393077 |
| 89 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.87614840 |
| 90 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.84908718 |
| 91 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83894602 |
| 92 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.80971149 |
| 93 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80873757 |
| 94 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80730973 |
| 95 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.79728796 |
| 96 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.79540879 |
| 97 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.77936832 |
| 98 | GATA3_26560356_Chip-Seq_TH1_Human | 0.74027513 |
| 99 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.73816313 |
| 100 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.69969820 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 5.02010584 |
| 2 | MP0003724_increased_susceptibility_to | 4.23998353 |
| 3 | MP0003436_decreased_susceptibility_to | 3.90780354 |
| 4 | MP0005671_abnormal_response_to | 3.90383793 |
| 5 | MP0002419_abnormal_innate_immunity | 3.18402280 |
| 6 | MP0001800_abnormal_humoral_immune | 3.18017255 |
| 7 | MP0005000_abnormal_immune_tolerance | 3.15058884 |
| 8 | MP0009785_altered_susceptibility_to | 3.13956221 |
| 9 | MP0003303_peritoneal_inflammation | 3.08271995 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.97762606 |
| 11 | MP0005025_abnormal_response_to | 2.96573399 |
| 12 | MP0006082_CNS_inflammation | 2.93210344 |
| 13 | MP0005387_immune_system_phenotype | 2.90433256 |
| 14 | MP0001790_abnormal_immune_system | 2.90433256 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.86293133 |
| 16 | MP0002723_abnormal_immune_serum | 2.81319720 |
| 17 | MP0000685_abnormal_immune_system | 2.74782217 |
| 18 | MP0001819_abnormal_immune_cell | 2.63369445 |
| 19 | MP0002420_abnormal_adaptive_immunity | 2.62939175 |
| 20 | MP0005464_abnormal_platelet_physiology | 2.24954590 |
| 21 | MP0003172_abnormal_lysosome_physiology | 2.18601171 |
| 22 | MP0001533_abnormal_skeleton_physiology | 2.00497221 |
| 23 | MP0003763_abnormal_thymus_physiology | 1.99790362 |
| 24 | MP0000716_abnormal_immune_system | 1.91753106 |
| 25 | MP0005058_abnormal_lysosome_morphology | 1.91225745 |
| 26 | MP0009764_decreased_sensitivity_to | 1.90999203 |
| 27 | MP0002405_respiratory_system_inflammati | 1.90442957 |
| 28 | MP0002398_abnormal_bone_marrow | 1.90425937 |
| 29 | MP0001845_abnormal_inflammatory_respons | 1.87255820 |
| 30 | MP0003300_gastrointestinal_ulcer | 1.86461719 |
| 31 | MP0003191_abnormal_cellular_cholesterol | 1.81803783 |
| 32 | MP0010155_abnormal_intestine_physiology | 1.79479147 |
| 33 | MP0000465_gastrointestinal_hemorrhage | 1.74496576 |
| 34 | MP0000689_abnormal_spleen_morphology | 1.61528103 |
| 35 | MP0003075_altered_response_to | 1.60475127 |
| 36 | MP0008469_abnormal_protein_level | 1.58515414 |
| 37 | MP0009333_abnormal_splenocyte_physiolog | 1.53221680 |
| 38 | MP0002429_abnormal_blood_cell | 1.49780215 |
| 39 | MP0004947_skin_inflammation | 1.48551294 |
| 40 | MP0003806_abnormal_nucleotide_metabolis | 1.48191550 |
| 41 | MP0009278_abnormal_bone_marrow | 1.46345594 |
| 42 | MP0003828_pulmonary_edema | 1.46015155 |
| 43 | MP0002722_abnormal_immune_system | 1.45188729 |
| 44 | MP0003866_abnormal_defecation | 1.40596751 |
| 45 | MP0002166_altered_tumor_susceptibility | 1.37965003 |
| 46 | MP0000858_altered_metastatic_potential | 1.37624603 |
| 47 | MP0001545_abnormal_hematopoietic_system | 1.34384893 |
| 48 | MP0005397_hematopoietic_system_phenotyp | 1.34384893 |
| 49 | MP0001853_heart_inflammation | 1.33667967 |
| 50 | MP0002998_abnormal_bone_remodeling | 1.28362799 |
| 51 | MP0005075_abnormal_melanosome_morpholog | 1.27929620 |
| 52 | MP0005166_decreased_susceptibility_to | 1.23140146 |
| 53 | MP0001851_eye_inflammation | 1.21730500 |
| 54 | MP0005310_abnormal_salivary_gland | 1.19385238 |
| 55 | MP0000343_altered_response_to | 1.17168925 |
| 56 | MP0003183_abnormal_peptide_metabolism | 1.13537678 |
| 57 | MP0000703_abnormal_thymus_morphology | 1.11721638 |
| 58 | MP0002396_abnormal_hematopoietic_system | 1.08888507 |
| 59 | MP0001873_stomach_inflammation | 1.02163931 |
| 60 | MP0004883_abnormal_blood_vessel | 0.98735738 |
| 61 | MP0008260_abnormal_autophagy | 0.97303395 |
| 62 | MP0009763_increased_sensitivity_to | 0.97168230 |
| 63 | MP0003690_abnormal_glial_cell | 0.96792448 |
| 64 | MP0008004_abnormal_stomach_pH | 0.96648556 |
| 65 | MP0003448_altered_tumor_morphology | 0.93980203 |
| 66 | MP0002132_abnormal_respiratory_system | 0.93865009 |
| 67 | MP0002006_tumorigenesis | 0.92899452 |
| 68 | MP0001986_abnormal_taste_sensitivity | 0.91859286 |
| 69 | MP0000604_amyloidosis | 0.90457647 |
| 70 | MP0004381_abnormal_hair_follicle | 0.88974590 |
| 71 | MP0002277_abnormal_respiratory_mucosa | 0.88603820 |
| 72 | MP0002138_abnormal_hepatobiliary_system | 0.88082684 |
| 73 | MP0004510_myositis | 0.81630019 |
| 74 | MP0005451_abnormal_body_composition | 0.80789470 |
| 75 | MP0001663_abnormal_digestive_system | 0.80565201 |
| 76 | MP0005164_abnormal_response_to | 0.79610406 |
| 77 | MP0005390_skeleton_phenotype | 0.78636293 |
| 78 | MP0000249_abnormal_blood_vessel | 0.75375941 |
| 79 | MP0002933_joint_inflammation | 0.70751216 |
| 80 | MP0000015_abnormal_ear_pigmentation | 0.68217059 |
| 81 | MP0009765_abnormal_xenobiotic_induced | 0.66558726 |
| 82 | MP0003656_abnormal_erythrocyte_physiolo | 0.64864941 |
| 83 | MP0002009_preneoplasia | 0.64020640 |
| 84 | MP0000920_abnormal_myelination | 0.63942482 |
| 85 | MP0003795_abnormal_bone_structure | 0.62169165 |
| 86 | MP0003045_fibrosis | 0.61948979 |
| 87 | MP0009840_abnormal_foam_cell | 0.60181457 |
| 88 | MP0005319_abnormal_enzyme/_coenzyme | 0.58481777 |
| 89 | MP0005167_abnormal_blood-brain_barrier | 0.57607841 |
| 90 | MP0005174_abnormal_tail_pigmentation | 0.56307978 |
| 91 | MP0004808_abnormal_hematopoietic_stem | 0.54864169 |
| 92 | MP0003638_abnormal_response/metabolism_ | 0.52568108 |
| 93 | MP0000490_abnormal_crypts_of | 0.51222572 |
| 94 | MP0005165_increased_susceptibility_to | 0.50946257 |
| 95 | MP0003011_delayed_dark_adaptation | 0.50779579 |
| 96 | MP0005535_abnormal_body_temperature | 0.49050820 |
| 97 | MP0006054_spinal_hemorrhage | 0.48523173 |
| 98 | MP0002332_abnormal_exercise_endurance | 0.46384335 |
| 99 | MP0008874_decreased_physiological_sensi | 0.45659805 |
| 100 | MP0006036_abnormal_mitochondrial_physio | 0.44572322 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 5.77254079 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 5.57738061 |
| 3 | Recurrent abscess formation (HP:0002722) | 5.54909831 |
| 4 | Abnormality of macrophages (HP:0004311) | 4.96592266 |
| 5 | Chronic obstructive pulmonary disease (HP:0006510) | 4.78640029 |
| 6 | Obstructive lung disease (HP:0006536) | 4.78640029 |
| 7 | Myositis (HP:0100614) | 4.67905403 |
| 8 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.67234804 |
| 9 | Stomatitis (HP:0010280) | 4.58499765 |
| 10 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.57323829 |
| 11 | Meningitis (HP:0001287) | 4.25736832 |
| 12 | Orchitis (HP:0100796) | 4.04551983 |
| 13 | Retrobulbar optic neuritis (HP:0100654) | 3.98783060 |
| 14 | Optic neuritis (HP:0100653) | 3.98783060 |
| 15 | Recurrent fungal infections (HP:0002841) | 3.97703306 |
| 16 | Mediastinal lymphadenopathy (HP:0100721) | 3.95197642 |
| 17 | Recurrent skin infections (HP:0001581) | 3.84444698 |
| 18 | Vasculitis (HP:0002633) | 3.69707488 |
| 19 | Gastrointestinal infarctions (HP:0005244) | 3.62063220 |
| 20 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.61875918 |
| 21 | Recurrent cutaneous fungal infections (HP:0011370) | 3.61875918 |
| 22 | Hemoptysis (HP:0002105) | 3.56658907 |
| 23 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.53222999 |
| 24 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.53222999 |
| 25 | Abnormality of glycolipid metabolism (HP:0010969) | 3.53222999 |
| 26 | Increased cerebral lipofuscin (HP:0011813) | 3.37662472 |
| 27 | Pulmonary infiltrates (HP:0002113) | 3.34485212 |
| 28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.33942347 |
| 29 | Encephalitis (HP:0002383) | 3.29158379 |
| 30 | Urticaria (HP:0001025) | 3.24960137 |
| 31 | Chest pain (HP:0100749) | 3.15396940 |
| 32 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.10779378 |
| 33 | Agammaglobulinemia (HP:0004432) | 3.06533149 |
| 34 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.00913061 |
| 35 | Systemic lupus erythematosus (HP:0002725) | 2.92231898 |
| 36 | Spontaneous hematomas (HP:0007420) | 2.90527691 |
| 37 | T lymphocytopenia (HP:0005403) | 2.90418667 |
| 38 | Increased IgM level (HP:0003496) | 2.90325944 |
| 39 | Panhypogammaglobulinemia (HP:0003139) | 2.90192337 |
| 40 | Epistaxis (HP:0000421) | 2.87303332 |
| 41 | Amyloidosis (HP:0011034) | 2.85130449 |
| 42 | Prolonged bleeding time (HP:0003010) | 2.84444167 |
| 43 | Keratoconjunctivitis sicca (HP:0001097) | 2.83565517 |
| 44 | Petechiae (HP:0000967) | 2.81810519 |
| 45 | Disinhibition (HP:0000734) | 2.81609628 |
| 46 | Gingivitis (HP:0000230) | 2.80331600 |
| 47 | Abnormality of the prostate (HP:0008775) | 2.80305869 |
| 48 | Abnormality of T cell number (HP:0011839) | 2.79650498 |
| 49 | Gingival bleeding (HP:0000225) | 2.76587348 |
| 50 | Recurrent viral infections (HP:0004429) | 2.70941404 |
| 51 | Keratoconjunctivitis (HP:0001096) | 2.70816522 |
| 52 | Cellulitis (HP:0100658) | 2.70529329 |
| 53 | Leukocytosis (HP:0001974) | 2.67660317 |
| 54 | Abnormality of the pleura (HP:0002103) | 2.64714222 |
| 55 | Increased IgE level (HP:0003212) | 2.62227180 |
| 56 | Gangrene (HP:0100758) | 2.61958205 |
| 57 | Dysostosis multiplex (HP:0000943) | 2.61534799 |
| 58 | Pulmonary embolism (HP:0002204) | 2.61364384 |
| 59 | Purpura (HP:0000979) | 2.60249184 |
| 60 | Inflammation of the large intestine (HP:0002037) | 2.59232529 |
| 61 | Vacuolated lymphocytes (HP:0001922) | 2.56444128 |
| 62 | Abnormality of T cells (HP:0002843) | 2.55532731 |
| 63 | Arterial thrombosis (HP:0004420) | 2.51751224 |
| 64 | Anorexia (HP:0002039) | 2.49728770 |
| 65 | Pustule (HP:0200039) | 2.48873927 |
| 66 | Gastrointestinal inflammation (HP:0004386) | 2.43693418 |
| 67 | Autoimmune thrombocytopenia (HP:0001973) | 2.41680343 |
| 68 | Glomerulopathy (HP:0100820) | 2.41304254 |
| 69 | Osteomyelitis (HP:0002754) | 2.40310113 |
| 70 | IgG deficiency (HP:0004315) | 2.39674704 |
| 71 | Loss of speech (HP:0002371) | 2.39581049 |
| 72 | Granulocytopenia (HP:0001913) | 2.37596068 |
| 73 | Skin rash (HP:0000988) | 2.34554529 |
| 74 | Hypergammaglobulinemia (HP:0010702) | 2.30078896 |
| 75 | Basal ganglia calcification (HP:0002135) | 2.29096815 |
| 76 | Episodic fever (HP:0001954) | 2.26290966 |
| 77 | Hypochromic microcytic anemia (HP:0004840) | 2.26078210 |
| 78 | Colitis (HP:0002583) | 2.24414382 |
| 79 | Polyneuropathy (HP:0001271) | 2.24215612 |
| 80 | Recurrent bronchitis (HP:0002837) | 2.22862879 |
| 81 | Restrictive lung disease (HP:0002091) | 2.20265817 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 2.19605635 |
| 83 | Eosinophilia (HP:0001880) | 2.18249152 |
| 84 | Abnormality of the pericardium (HP:0001697) | 2.16261490 |
| 85 | Increased serum ferritin (HP:0003281) | 2.15725302 |
| 86 | Abnormality of eosinophils (HP:0001879) | 2.15231691 |
| 87 | Recurrent pneumonia (HP:0006532) | 2.15173632 |
| 88 | Pulmonary fibrosis (HP:0002206) | 2.14200682 |
| 89 | Hepatosplenomegaly (HP:0001433) | 2.13473876 |
| 90 | Abnormality of iron homeostasis (HP:0011031) | 2.10411689 |
| 91 | Hypochromic anemia (HP:0001931) | 2.09265402 |
| 92 | Vertigo (HP:0002321) | 2.09156092 |
| 93 | Thrombocytosis (HP:0001894) | 2.08029008 |
| 94 | Sepsis (HP:0100806) | 2.07336695 |
| 95 | Agnosia (HP:0010524) | 2.06148262 |
| 96 | Amaurosis fugax (HP:0100576) | 2.01126767 |
| 97 | Skin ulcer (HP:0200042) | 1.96207325 |
| 98 | Recurrent sinusitis (HP:0011108) | 1.95169645 |
| 99 | Thrombophlebitis (HP:0004418) | 1.93825882 |
| 100 | Arthralgia (HP:0002829) | 1.93170667 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 4.43706725 |
| 2 | MAP4K1 | 3.53871558 |
| 3 | BLK | 3.36750511 |
| 4 | TXK | 2.98879131 |
| 5 | TAOK3 | 2.88617740 |
| 6 | BMPR2 | 2.88367725 |
| 7 | FES | 2.81755180 |
| 8 | TYK2 | 2.50108844 |
| 9 | IRAK4 | 2.36536724 |
| 10 | GRK6 | 2.33448850 |
| 11 | SYK | 2.30391259 |
| 12 | CSK | 2.26903696 |
| 13 | CDK19 | 2.24076962 |
| 14 | ZAP70 | 2.22395868 |
| 15 | CSF1R | 2.19733764 |
| 16 | KIT | 2.19054008 |
| 17 | MAP3K14 | 2.10860838 |
| 18 | BTK | 2.10749724 |
| 19 | MAP2K3 | 2.09798396 |
| 20 | TNK2 | 2.09064376 |
| 21 | JAK3 | 1.97212994 |
| 22 | LYN | 1.81641372 |
| 23 | TBK1 | 1.75784004 |
| 24 | IKBKE | 1.69041730 |
| 25 | HCK | 1.64875384 |
| 26 | IKBKB | 1.63819137 |
| 27 | TEC | 1.62432866 |
| 28 | ERN1 | 1.62345325 |
| 29 | TESK2 | 1.58320529 |
| 30 | MATK | 1.54600821 |
| 31 | LCK | 1.51969283 |
| 32 | ITK | 1.50194450 |
| 33 | FGR | 1.49533941 |
| 34 | MAP3K13 | 1.43354464 |
| 35 | JAK1 | 1.35730685 |
| 36 | MAP3K3 | 1.30122710 |
| 37 | MAP3K11 | 1.17410636 |
| 38 | GRK7 | 1.15680822 |
| 39 | MARK3 | 1.09551973 |
| 40 | MAP3K12 | 1.09464787 |
| 41 | PRPF4B | 1.05921123 |
| 42 | JAK2 | 1.04851294 |
| 43 | KDR | 1.03305385 |
| 44 | PIK3CG | 1.00273849 |
| 45 | TAOK1 | 0.99647229 |
| 46 | TGFBR2 | 0.98696954 |
| 47 | TAOK2 | 0.89396725 |
| 48 | SCYL2 | 0.89111847 |
| 49 | TRPM7 | 0.86805197 |
| 50 | MAP3K1 | 0.82415424 |
| 51 | SIK3 | 0.79318883 |
| 52 | TLK1 | 0.71449006 |
| 53 | PDK1 | 0.69353771 |
| 54 | EPHB1 | 0.67115492 |
| 55 | FYN | 0.66455877 |
| 56 | PIM1 | 0.63816378 |
| 57 | PRKCQ | 0.63729213 |
| 58 | MAPK12 | 0.61643805 |
| 59 | MAPK7 | 0.60308032 |
| 60 | CAMKK2 | 0.60294927 |
| 61 | STK10 | 0.57592188 |
| 62 | MAP2K2 | 0.53656939 |
| 63 | ABL1 | 0.53255094 |
| 64 | PDPK1 | 0.51215614 |
| 65 | BCKDK | 0.50810592 |
| 66 | IRAK1 | 0.49101743 |
| 67 | PTK2B | 0.44514523 |
| 68 | IRAK3 | 0.43294656 |
| 69 | SIK2 | 0.42993558 |
| 70 | YES1 | 0.42968969 |
| 71 | PRKCD | 0.42926485 |
| 72 | RPS6KL1 | 0.42715656 |
| 73 | RPS6KC1 | 0.42715656 |
| 74 | MAP3K5 | 0.41798238 |
| 75 | LRRK2 | 0.41272117 |
| 76 | RPS6KA6 | 0.40593652 |
| 77 | MAP2K6 | 0.38568735 |
| 78 | MOS | 0.37981896 |
| 79 | IGF1R | 0.36320388 |
| 80 | FLT3 | 0.35554290 |
| 81 | ADRBK2 | 0.33560065 |
| 82 | CAMKK1 | 0.33298296 |
| 83 | MYLK | 0.33019053 |
| 84 | DAPK2 | 0.32493463 |
| 85 | EGFR | 0.32366654 |
| 86 | HIPK2 | 0.32091918 |
| 87 | CDC42BPA | 0.30189325 |
| 88 | ILK | 0.29984521 |
| 89 | MAPKAPK2 | 0.29881668 |
| 90 | MARK2 | 0.29553984 |
| 91 | DYRK1B | 0.25967860 |
| 92 | MAPK4 | 0.25329775 |
| 93 | PRKD2 | 0.24950020 |
| 94 | IRAK2 | 0.24692699 |
| 95 | CDK6 | 0.24200562 |
| 96 | OXSR1 | 0.21833452 |
| 97 | PRKD1 | 0.21585456 |
| 98 | CHUK | 0.20915696 |
| 99 | MAP3K6 | 0.19959752 |
| 100 | INSR | 0.18968304 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Asthma_Homo sapiens_hsa05310 | 4.47402015 |
| 2 | Allograft rejection_Homo sapiens_hsa05330 | 4.29998378 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.15713205 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 4.00233976 |
| 5 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.64566045 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.39993160 |
| 7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.32017672 |
| 8 | Leishmaniasis_Homo sapiens_hsa05140 | 3.27116983 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.77583795 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.72427148 |
| 11 | Viral myocarditis_Homo sapiens_hsa05416 | 2.53480471 |
| 12 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.25726575 |
| 13 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.22311825 |
| 14 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.15077500 |
| 15 | Tuberculosis_Homo sapiens_hsa05152 | 2.11427200 |
| 16 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.86884245 |
| 17 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.75664703 |
| 18 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.66103592 |
| 19 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.65260364 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.63704870 |
| 21 | Phagosome_Homo sapiens_hsa04145 | 1.59582014 |
| 22 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.56865118 |
| 23 | Malaria_Homo sapiens_hsa05144 | 1.48586608 |
| 24 | Influenza A_Homo sapiens_hsa05164 | 1.44258353 |
| 25 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.43111174 |
| 26 | Other glycan degradation_Homo sapiens_hsa00511 | 1.41444199 |
| 27 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.37571481 |
| 28 | Legionellosis_Homo sapiens_hsa05134 | 1.28930452 |
| 29 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.24251253 |
| 30 | Pertussis_Homo sapiens_hsa05133 | 1.21616182 |
| 31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.21062298 |
| 32 | Lysosome_Homo sapiens_hsa04142 | 1.14736552 |
| 33 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.10677798 |
| 34 | Measles_Homo sapiens_hsa05162 | 1.09527410 |
| 35 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.09449307 |
| 36 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.06831257 |
| 37 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.97930577 |
| 38 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.97802279 |
| 39 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.96680285 |
| 40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.96377491 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.95617138 |
| 42 | Salmonella infection_Homo sapiens_hsa05132 | 0.90230030 |
| 43 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.84121525 |
| 44 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.83733180 |
| 45 | Platelet activation_Homo sapiens_hsa04611 | 0.82438544 |
| 46 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.81823147 |
| 47 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.77808282 |
| 48 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.75717360 |
| 49 | Shigellosis_Homo sapiens_hsa05131 | 0.75543214 |
| 50 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.71886649 |
| 51 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.69514388 |
| 52 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.66638710 |
| 53 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.63914842 |
| 54 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.60952930 |
| 55 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.49973884 |
| 56 | Hepatitis B_Homo sapiens_hsa05161 | 0.48160279 |
| 57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44875435 |
| 58 | Apoptosis_Homo sapiens_hsa04210 | 0.44603324 |
| 59 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.43873142 |
| 60 | Hepatitis C_Homo sapiens_hsa05160 | 0.43851276 |
| 61 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42663436 |
| 62 | HTLV-I infection_Homo sapiens_hsa05166 | 0.41878988 |
| 63 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.39902623 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39712469 |
| 65 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.38530847 |
| 66 | Endocytosis_Homo sapiens_hsa04144 | 0.36479492 |
| 67 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.31714441 |
| 68 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.31131124 |
| 69 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.30618390 |
| 70 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.27153003 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.27138842 |
| 72 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.26920947 |
| 73 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.25765625 |
| 74 | Amoebiasis_Homo sapiens_hsa05146 | 0.24645254 |
| 75 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.23042302 |
| 76 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.22833660 |
| 77 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.21061572 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.20612347 |
| 79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.20472721 |
| 80 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.18492890 |
| 81 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.16008644 |
| 82 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.15078517 |
| 83 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.14231829 |
| 84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.13436256 |
| 85 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.10775107 |
| 86 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.10051549 |
| 87 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.09719980 |
| 88 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.08950183 |
| 89 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.08498288 |
| 90 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.05450859 |
| 91 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.05313467 |
| 92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.04685072 |
| 93 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.03396856 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.02539022 |
| 95 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.02243983 |
| 96 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.01799457 |
| 97 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.01080196 |
| 98 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.01011551 |
| 99 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | -0.0184412 |
| 100 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | -0.0032502 |

