C1ORF162

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.61868816
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.56396145
3immunoglobulin mediated immune response (GO:0016064)5.26339254
4positive regulation of gamma-delta T cell activation (GO:0046645)5.15261157
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88559816
6negative regulation of cell killing (GO:0031342)4.88559816
7regulation of B cell receptor signaling pathway (GO:0050855)4.84987571
8positive regulation of mast cell activation (GO:0033005)4.81544130
9positive regulation of mast cell degranulation (GO:0043306)4.77573026
10positive regulation of mast cell activation involved in immune response (GO:0033008)4.77573026
11response to peptidoglycan (GO:0032494)4.74877271
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.73957215
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.73957215
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.73957215
15modulation by symbiont of host immune response (GO:0052553)4.73957215
16positive regulation by symbiont of host defense response (GO:0052509)4.73957215
17modulation by symbiont of host defense response (GO:0052031)4.73957215
18macrophage activation involved in immune response (GO:0002281)4.66771510
19antigen processing and presentation of endogenous antigen (GO:0019883)4.61823041
20detection of other organism (GO:0098543)4.54133586
21detection of bacterium (GO:0016045)4.48220105
22regulation of mast cell degranulation (GO:0043304)4.41998162
23neutrophil activation (GO:0042119)4.32117200
24microglial cell activation (GO:0001774)4.17980636
25B cell mediated immunity (GO:0019724)4.12726301
26interferon-gamma-mediated signaling pathway (GO:0060333)4.10251768
27regulation of mast cell activation involved in immune response (GO:0033006)4.07709919
28myeloid cell activation involved in immune response (GO:0002275)4.06022529
29granulocyte activation (GO:0036230)4.03561688
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98887073
31regulation of mast cell activation (GO:0033003)3.98842682
32negative regulation of interleukin-12 production (GO:0032695)3.97150023
33positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.90329268
34detection of external biotic stimulus (GO:0098581)3.89529481
35regulation of hypersensitivity (GO:0002883)3.79744672
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.78077795
37cellular extravasation (GO:0045123)3.77380248
38regulation of interferon-beta biosynthetic process (GO:0045357)3.75977724
39leukocyte aggregation (GO:0070486)3.75502210
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75300912
41regulation of gamma-delta T cell activation (GO:0046643)3.67760777
42positive regulation of antigen processing and presentation (GO:0002579)3.63848053
43respiratory burst (GO:0045730)3.62366615
44positive thymic T cell selection (GO:0045059)3.62176141
45macrophage activation (GO:0042116)3.60297760
46regulation of T cell tolerance induction (GO:0002664)3.59085633
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57937863
48regulation of antigen processing and presentation (GO:0002577)3.57221075
49regulation of tolerance induction (GO:0002643)3.56819547
50regulation of leukocyte degranulation (GO:0043300)3.56653126
51detection of molecule of bacterial origin (GO:0032490)3.55607679
52antigen processing and presentation via MHC class Ib (GO:0002475)3.51556496
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47785768
54mast cell activation (GO:0045576)3.47267381
55detection of biotic stimulus (GO:0009595)3.45708617
56positive regulation of leukocyte degranulation (GO:0043302)3.45694541
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.45059091
58defense response to protozoan (GO:0042832)3.37350939
59positive regulation of B cell differentiation (GO:0045579)3.34260648
60response to host immune response (GO:0052572)3.31753004
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31753004
62B cell receptor signaling pathway (GO:0050853)3.26410455
63Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25509517
64positive regulation of type 2 immune response (GO:0002830)3.24324794
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.23718006
66regulation of gamma-delta T cell differentiation (GO:0045586)3.23157996
67negative thymic T cell selection (GO:0045060)3.18822765
68response to muramyl dipeptide (GO:0032495)3.17899556
69cellular response to interferon-gamma (GO:0071346)3.17100085
70regulation of B cell differentiation (GO:0045577)3.16237790
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14793471
72regulation of alpha-beta T cell proliferation (GO:0046640)3.13277320
73leukocyte degranulation (GO:0043299)3.12230151
74negative T cell selection (GO:0043383)3.10935682
75negative regulation of T cell mediated immunity (GO:0002710)3.07232832
76response to protozoan (GO:0001562)3.04741102
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.04467469
78T cell costimulation (GO:0031295)3.03886736
79regulation of germinal center formation (GO:0002634)3.03640372
80lymphocyte costimulation (GO:0031294)2.99656454
81regulation of T-helper 2 cell differentiation (GO:0045628)2.99303622
82myeloid leukocyte activation (GO:0002274)2.98361398
83negative regulation of leukocyte mediated immunity (GO:0002704)2.97620638
84cellular response to type I interferon (GO:0071357)2.96966269
85type I interferon signaling pathway (GO:0060337)2.96966269
86regulation of regulated secretory pathway (GO:1903305)2.96685454
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96095852
88response to interferon-gamma (GO:0034341)2.95462250
89response to type I interferon (GO:0034340)2.93325322
90neutrophil mediated immunity (GO:0002446)2.92406033
91production of molecular mediator involved in inflammatory response (GO:0002532)2.91772331
92positive T cell selection (GO:0043368)2.91695920
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91675294
94response to host (GO:0075136)2.91675294
95response to host defenses (GO:0052200)2.91675294
96antigen receptor-mediated signaling pathway (GO:0050851)2.91520709
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90469168
98positive regulation of regulated secretory pathway (GO:1903307)2.84643728
99myeloid dendritic cell activation (GO:0001773)2.83212346
100regulation of T cell mediated cytotoxicity (GO:0001914)2.83139507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.61424606
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.21246858
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.19670034
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71256260
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55624530
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.46190300
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44553600
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.27440143
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25638848
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15518686
11SPI1_23547873_ChIP-Seq_NB4_Human2.95251841
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82802736
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77764079
14SCL_19346495_ChIP-Seq_HPC-7_Human2.76110498
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73973362
16RUNX_20019798_ChIP-Seq_JUKART_Human2.62640705
17MYB_26560356_Chip-Seq_TH2_Human2.57868433
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57842929
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55504107
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50404791
21VDR_24763502_ChIP-Seq_THP-1_Human2.47031842
22SPI1_23127762_ChIP-Seq_K562_Human2.42593159
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35098341
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28241892
25VDR_21846776_ChIP-Seq_THP-1_Human2.27707123
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23205637
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.04973896
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04216113
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03492952
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01118023
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00684295
32* MAF_26560356_Chip-Seq_TH1_Human1.95953543
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93982808
34MYB_26560356_Chip-Seq_TH1_Human1.91586167
35VDR_24787735_ChIP-Seq_THP-1_Human1.86286872
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85716098
37* UTX_26944678_Chip-Seq_JUKART_Human1.79790500
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76744741
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.75781317
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75361087
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69950963
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69046185
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68172839
44* GATA3_26560356_Chip-Seq_TH2_Human1.66356847
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58175309
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53801897
47MYC_22102868_ChIP-Seq_BL_Human1.52379828
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47692158
49* MAF_26560356_Chip-Seq_TH2_Human1.42744910
50GATA1_22025678_ChIP-Seq_K562_Human1.36038442
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35569968
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34058980
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33788017
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31787764
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29844443
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29098283
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28645604
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28396940
59PU_27001747_Chip-Seq_BMDM_Mouse1.28324127
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25364069
61BCL6_27268052_Chip-Seq_Bcells_Human1.24346475
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23572498
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.21864388
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19032296
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13460129
66SPI1_20517297_ChIP-Seq_HL60_Human1.09330952
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08388171
68TCF7_22412390_ChIP-Seq_EML_Mouse1.08225426
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06318889
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.06164978
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05233078
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03808246
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01512798
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.00253532
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99368226
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98993596
77STAT1_20625510_ChIP-Seq_HELA_Human0.97985712
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97052268
79BCOR_27268052_Chip-Seq_Bcells_Human0.95074050
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.93922269
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92951676
82KDM2B_26808549_Chip-Seq_DND41_Human0.92781259
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92704968
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91232459
85GATA1_19941826_ChIP-Seq_K562_Human0.90920697
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90290253
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.89670934
88P300_27268052_Chip-Seq_Bcells_Human0.88393077
89CIITA_25753668_ChIP-Seq_RAJI_Human0.87614840
90SMRT_27268052_Chip-Seq_Bcells_Human0.84908718
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83894602
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80971149
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80873757
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80730973
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79728796
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79540879
97LXR_22292898_ChIP-Seq_THP-1_Human0.77936832
98GATA3_26560356_Chip-Seq_TH1_Human0.74027513
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73816313
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69969820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.02010584
2MP0003724_increased_susceptibility_to4.23998353
3MP0003436_decreased_susceptibility_to3.90780354
4MP0005671_abnormal_response_to3.90383793
5MP0002419_abnormal_innate_immunity3.18402280
6MP0001800_abnormal_humoral_immune3.18017255
7MP0005000_abnormal_immune_tolerance3.15058884
8MP0009785_altered_susceptibility_to3.13956221
9MP0003303_peritoneal_inflammation3.08271995
10MP0002148_abnormal_hypersensitivity_rea2.97762606
11MP0005025_abnormal_response_to2.96573399
12MP0006082_CNS_inflammation2.93210344
13MP0005387_immune_system_phenotype2.90433256
14MP0001790_abnormal_immune_system2.90433256
15MP0002452_abnormal_antigen_presenting2.86293133
16MP0002723_abnormal_immune_serum2.81319720
17MP0000685_abnormal_immune_system2.74782217
18MP0001819_abnormal_immune_cell2.63369445
19MP0002420_abnormal_adaptive_immunity2.62939175
20MP0005464_abnormal_platelet_physiology2.24954590
21MP0003172_abnormal_lysosome_physiology2.18601171
22MP0001533_abnormal_skeleton_physiology2.00497221
23MP0003763_abnormal_thymus_physiology1.99790362
24MP0000716_abnormal_immune_system1.91753106
25MP0005058_abnormal_lysosome_morphology1.91225745
26MP0009764_decreased_sensitivity_to1.90999203
27MP0002405_respiratory_system_inflammati1.90442957
28MP0002398_abnormal_bone_marrow1.90425937
29MP0001845_abnormal_inflammatory_respons1.87255820
30MP0003300_gastrointestinal_ulcer1.86461719
31MP0003191_abnormal_cellular_cholesterol1.81803783
32MP0010155_abnormal_intestine_physiology1.79479147
33MP0000465_gastrointestinal_hemorrhage1.74496576
34MP0000689_abnormal_spleen_morphology1.61528103
35MP0003075_altered_response_to1.60475127
36MP0008469_abnormal_protein_level1.58515414
37MP0009333_abnormal_splenocyte_physiolog1.53221680
38MP0002429_abnormal_blood_cell1.49780215
39MP0004947_skin_inflammation1.48551294
40MP0003806_abnormal_nucleotide_metabolis1.48191550
41MP0009278_abnormal_bone_marrow1.46345594
42MP0003828_pulmonary_edema1.46015155
43MP0002722_abnormal_immune_system1.45188729
44MP0003866_abnormal_defecation1.40596751
45MP0002166_altered_tumor_susceptibility1.37965003
46MP0000858_altered_metastatic_potential1.37624603
47MP0001545_abnormal_hematopoietic_system1.34384893
48MP0005397_hematopoietic_system_phenotyp1.34384893
49MP0001853_heart_inflammation1.33667967
50MP0002998_abnormal_bone_remodeling1.28362799
51MP0005075_abnormal_melanosome_morpholog1.27929620
52MP0005166_decreased_susceptibility_to1.23140146
53MP0001851_eye_inflammation1.21730500
54MP0005310_abnormal_salivary_gland1.19385238
55MP0000343_altered_response_to1.17168925
56MP0003183_abnormal_peptide_metabolism1.13537678
57MP0000703_abnormal_thymus_morphology1.11721638
58MP0002396_abnormal_hematopoietic_system1.08888507
59MP0001873_stomach_inflammation1.02163931
60MP0004883_abnormal_blood_vessel0.98735738
61MP0008260_abnormal_autophagy0.97303395
62MP0009763_increased_sensitivity_to0.97168230
63MP0003690_abnormal_glial_cell0.96792448
64MP0008004_abnormal_stomach_pH0.96648556
65MP0003448_altered_tumor_morphology0.93980203
66MP0002132_abnormal_respiratory_system0.93865009
67MP0002006_tumorigenesis0.92899452
68MP0001986_abnormal_taste_sensitivity0.91859286
69MP0000604_amyloidosis0.90457647
70MP0004381_abnormal_hair_follicle0.88974590
71MP0002277_abnormal_respiratory_mucosa0.88603820
72MP0002138_abnormal_hepatobiliary_system0.88082684
73MP0004510_myositis0.81630019
74MP0005451_abnormal_body_composition0.80789470
75MP0001663_abnormal_digestive_system0.80565201
76MP0005164_abnormal_response_to0.79610406
77MP0005390_skeleton_phenotype0.78636293
78MP0000249_abnormal_blood_vessel0.75375941
79MP0002933_joint_inflammation0.70751216
80MP0000015_abnormal_ear_pigmentation0.68217059
81MP0009765_abnormal_xenobiotic_induced0.66558726
82MP0003656_abnormal_erythrocyte_physiolo0.64864941
83MP0002009_preneoplasia0.64020640
84MP0000920_abnormal_myelination0.63942482
85MP0003795_abnormal_bone_structure0.62169165
86MP0003045_fibrosis0.61948979
87MP0009840_abnormal_foam_cell0.60181457
88MP0005319_abnormal_enzyme/_coenzyme0.58481777
89MP0005167_abnormal_blood-brain_barrier0.57607841
90MP0005174_abnormal_tail_pigmentation0.56307978
91MP0004808_abnormal_hematopoietic_stem0.54864169
92MP0003638_abnormal_response/metabolism_0.52568108
93MP0000490_abnormal_crypts_of0.51222572
94MP0005165_increased_susceptibility_to0.50946257
95MP0003011_delayed_dark_adaptation0.50779579
96MP0005535_abnormal_body_temperature0.49050820
97MP0006054_spinal_hemorrhage0.48523173
98MP0002332_abnormal_exercise_endurance0.46384335
99MP0008874_decreased_physiological_sensi0.45659805
100MP0006036_abnormal_mitochondrial_physio0.44572322

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.77254079
2Recurrent bacterial skin infections (HP:0005406)5.57738061
3Recurrent abscess formation (HP:0002722)5.54909831
4Abnormality of macrophages (HP:0004311)4.96592266
5Chronic obstructive pulmonary disease (HP:0006510)4.78640029
6Obstructive lung disease (HP:0006536)4.78640029
7Myositis (HP:0100614)4.67905403
8Recurrent gram-negative bacterial infections (HP:0005420)4.67234804
9Stomatitis (HP:0010280)4.58499765
10Elevated erythrocyte sedimentation rate (HP:0003565)4.57323829
11Meningitis (HP:0001287)4.25736832
12Orchitis (HP:0100796)4.04551983
13Retrobulbar optic neuritis (HP:0100654)3.98783060
14Optic neuritis (HP:0100653)3.98783060
15Recurrent fungal infections (HP:0002841)3.97703306
16Mediastinal lymphadenopathy (HP:0100721)3.95197642
17Recurrent skin infections (HP:0001581)3.84444698
18Vasculitis (HP:0002633)3.69707488
19Gastrointestinal infarctions (HP:0005244)3.62063220
20Chronic mucocutaneous candidiasis (HP:0002728)3.61875918
21Recurrent cutaneous fungal infections (HP:0011370)3.61875918
22Hemoptysis (HP:0002105)3.56658907
23Abnormality of liposaccharide metabolism (HP:0010968)3.53222999
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.53222999
25Abnormality of glycolipid metabolism (HP:0010969)3.53222999
26Increased cerebral lipofuscin (HP:0011813)3.37662472
27Pulmonary infiltrates (HP:0002113)3.34485212
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.33942347
29Encephalitis (HP:0002383)3.29158379
30Urticaria (HP:0001025)3.24960137
31Chest pain (HP:0100749)3.15396940
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.10779378
33Agammaglobulinemia (HP:0004432)3.06533149
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00913061
35Systemic lupus erythematosus (HP:0002725)2.92231898
36Spontaneous hematomas (HP:0007420)2.90527691
37T lymphocytopenia (HP:0005403)2.90418667
38Increased IgM level (HP:0003496)2.90325944
39Panhypogammaglobulinemia (HP:0003139)2.90192337
40Epistaxis (HP:0000421)2.87303332
41Amyloidosis (HP:0011034)2.85130449
42Prolonged bleeding time (HP:0003010)2.84444167
43Keratoconjunctivitis sicca (HP:0001097)2.83565517
44Petechiae (HP:0000967)2.81810519
45Disinhibition (HP:0000734)2.81609628
46Gingivitis (HP:0000230)2.80331600
47Abnormality of the prostate (HP:0008775)2.80305869
48Abnormality of T cell number (HP:0011839)2.79650498
49Gingival bleeding (HP:0000225)2.76587348
50Recurrent viral infections (HP:0004429)2.70941404
51Keratoconjunctivitis (HP:0001096)2.70816522
52Cellulitis (HP:0100658)2.70529329
53Leukocytosis (HP:0001974)2.67660317
54Abnormality of the pleura (HP:0002103)2.64714222
55Increased IgE level (HP:0003212)2.62227180
56Gangrene (HP:0100758)2.61958205
57Dysostosis multiplex (HP:0000943)2.61534799
58Pulmonary embolism (HP:0002204)2.61364384
59Purpura (HP:0000979)2.60249184
60Inflammation of the large intestine (HP:0002037)2.59232529
61Vacuolated lymphocytes (HP:0001922)2.56444128
62Abnormality of T cells (HP:0002843)2.55532731
63Arterial thrombosis (HP:0004420)2.51751224
64Anorexia (HP:0002039)2.49728770
65Pustule (HP:0200039)2.48873927
66Gastrointestinal inflammation (HP:0004386)2.43693418
67Autoimmune thrombocytopenia (HP:0001973)2.41680343
68Glomerulopathy (HP:0100820)2.41304254
69Osteomyelitis (HP:0002754)2.40310113
70IgG deficiency (HP:0004315)2.39674704
71Loss of speech (HP:0002371)2.39581049
72Granulocytopenia (HP:0001913)2.37596068
73Skin rash (HP:0000988)2.34554529
74Hypergammaglobulinemia (HP:0010702)2.30078896
75Basal ganglia calcification (HP:0002135)2.29096815
76Episodic fever (HP:0001954)2.26290966
77Hypochromic microcytic anemia (HP:0004840)2.26078210
78Colitis (HP:0002583)2.24414382
79Polyneuropathy (HP:0001271)2.24215612
80Recurrent bronchitis (HP:0002837)2.22862879
81Restrictive lung disease (HP:0002091)2.20265817
82Abnormality of T cell physiology (HP:0011840)2.19605635
83Eosinophilia (HP:0001880)2.18249152
84Abnormality of the pericardium (HP:0001697)2.16261490
85Increased serum ferritin (HP:0003281)2.15725302
86Abnormality of eosinophils (HP:0001879)2.15231691
87Recurrent pneumonia (HP:0006532)2.15173632
88Pulmonary fibrosis (HP:0002206)2.14200682
89Hepatosplenomegaly (HP:0001433)2.13473876
90Abnormality of iron homeostasis (HP:0011031)2.10411689
91Hypochromic anemia (HP:0001931)2.09265402
92Vertigo (HP:0002321)2.09156092
93Thrombocytosis (HP:0001894)2.08029008
94Sepsis (HP:0100806)2.07336695
95Agnosia (HP:0010524)2.06148262
96Amaurosis fugax (HP:0100576)2.01126767
97Skin ulcer (HP:0200042)1.96207325
98Recurrent sinusitis (HP:0011108)1.95169645
99Thrombophlebitis (HP:0004418)1.93825882
100Arthralgia (HP:0002829)1.93170667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.43706725
2MAP4K13.53871558
3BLK3.36750511
4TXK2.98879131
5TAOK32.88617740
6BMPR22.88367725
7FES2.81755180
8TYK22.50108844
9IRAK42.36536724
10GRK62.33448850
11SYK2.30391259
12CSK2.26903696
13CDK192.24076962
14ZAP702.22395868
15CSF1R2.19733764
16KIT2.19054008
17MAP3K142.10860838
18BTK2.10749724
19MAP2K32.09798396
20TNK22.09064376
21JAK31.97212994
22LYN1.81641372
23TBK11.75784004
24IKBKE1.69041730
25HCK1.64875384
26IKBKB1.63819137
27TEC1.62432866
28ERN11.62345325
29TESK21.58320529
30MATK1.54600821
31LCK1.51969283
32ITK1.50194450
33FGR1.49533941
34MAP3K131.43354464
35JAK11.35730685
36MAP3K31.30122710
37MAP3K111.17410636
38GRK71.15680822
39MARK31.09551973
40MAP3K121.09464787
41PRPF4B1.05921123
42JAK21.04851294
43KDR1.03305385
44PIK3CG1.00273849
45TAOK10.99647229
46TGFBR20.98696954
47TAOK20.89396725
48SCYL20.89111847
49TRPM70.86805197
50MAP3K10.82415424
51SIK30.79318883
52TLK10.71449006
53PDK10.69353771
54EPHB10.67115492
55FYN0.66455877
56PIM10.63816378
57PRKCQ0.63729213
58MAPK120.61643805
59MAPK70.60308032
60CAMKK20.60294927
61STK100.57592188
62MAP2K20.53656939
63ABL10.53255094
64PDPK10.51215614
65BCKDK0.50810592
66IRAK10.49101743
67PTK2B0.44514523
68IRAK30.43294656
69SIK20.42993558
70YES10.42968969
71PRKCD0.42926485
72RPS6KL10.42715656
73RPS6KC10.42715656
74MAP3K50.41798238
75LRRK20.41272117
76RPS6KA60.40593652
77MAP2K60.38568735
78MOS0.37981896
79IGF1R0.36320388
80FLT30.35554290
81ADRBK20.33560065
82CAMKK10.33298296
83MYLK0.33019053
84DAPK20.32493463
85EGFR0.32366654
86HIPK20.32091918
87CDC42BPA0.30189325
88ILK0.29984521
89MAPKAPK20.29881668
90MARK20.29553984
91DYRK1B0.25967860
92MAPK40.25329775
93PRKD20.24950020
94IRAK20.24692699
95CDK60.24200562
96OXSR10.21833452
97PRKD10.21585456
98CHUK0.20915696
99MAP3K60.19959752
100INSR0.18968304

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.47402015
2Allograft rejection_Homo sapiens_hsa053304.29998378
3Graft-versus-host disease_Homo sapiens_hsa053324.15713205
4Autoimmune thyroid disease_Homo sapiens_hsa053204.00233976
5Staphylococcus aureus infection_Homo sapiens_hsa051503.64566045
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.39993160
7Type I diabetes mellitus_Homo sapiens_hsa049403.32017672
8Leishmaniasis_Homo sapiens_hsa051403.27116983
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77583795
10Antigen processing and presentation_Homo sapiens_hsa046122.72427148
11Viral myocarditis_Homo sapiens_hsa054162.53480471
12Rheumatoid arthritis_Homo sapiens_hsa053232.25726575
13Osteoclast differentiation_Homo sapiens_hsa043802.22311825
14Primary immunodeficiency_Homo sapiens_hsa053402.15077500
15Tuberculosis_Homo sapiens_hsa051522.11427200
16Hematopoietic cell lineage_Homo sapiens_hsa046401.86884245
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75664703
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66103592
19Toxoplasmosis_Homo sapiens_hsa051451.65260364
20B cell receptor signaling pathway_Homo sapiens_hsa046621.63704870
21Phagosome_Homo sapiens_hsa041451.59582014
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56865118
23Malaria_Homo sapiens_hsa051441.48586608
24Influenza A_Homo sapiens_hsa051641.44258353
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.43111174
26Other glycan degradation_Homo sapiens_hsa005111.41444199
27Herpes simplex infection_Homo sapiens_hsa051681.37571481
28Legionellosis_Homo sapiens_hsa051341.28930452
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24251253
30Pertussis_Homo sapiens_hsa051331.21616182
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21062298
32Lysosome_Homo sapiens_hsa041421.14736552
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10677798
34Measles_Homo sapiens_hsa051621.09527410
35T cell receptor signaling pathway_Homo sapiens_hsa046601.09449307
36Chemokine signaling pathway_Homo sapiens_hsa040621.06831257
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97930577
38African trypanosomiasis_Homo sapiens_hsa051430.97802279
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96680285
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96377491
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.95617138
42Salmonella infection_Homo sapiens_hsa051320.90230030
43TNF signaling pathway_Homo sapiens_hsa046680.84121525
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83733180
45Platelet activation_Homo sapiens_hsa046110.82438544
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.81823147
47Systemic lupus erythematosus_Homo sapiens_hsa053220.77808282
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75717360
49Shigellosis_Homo sapiens_hsa051310.75543214
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.71886649
51Epstein-Barr virus infection_Homo sapiens_hsa051690.69514388
52Acute myeloid leukemia_Homo sapiens_hsa052210.66638710
53Collecting duct acid secretion_Homo sapiens_hsa049660.63914842
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60952930
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49973884
56Hepatitis B_Homo sapiens_hsa051610.48160279
57Regulation of autophagy_Homo sapiens_hsa041400.44875435
58Apoptosis_Homo sapiens_hsa042100.44603324
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43873142
60Hepatitis C_Homo sapiens_hsa051600.43851276
61Arachidonic acid metabolism_Homo sapiens_hsa005900.42663436
62HTLV-I infection_Homo sapiens_hsa051660.41878988
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39902623
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39712469
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.38530847
66Endocytosis_Homo sapiens_hsa041440.36479492
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31714441
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31131124
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30618390
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27153003
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27138842
72Linoleic acid metabolism_Homo sapiens_hsa005910.26920947
73Complement and coagulation cascades_Homo sapiens_hsa046100.25765625
74Amoebiasis_Homo sapiens_hsa051460.24645254
75VEGF signaling pathway_Homo sapiens_hsa043700.23042302
76Ether lipid metabolism_Homo sapiens_hsa005650.22833660
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21061572
78Non-small cell lung cancer_Homo sapiens_hsa052230.20612347
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.20472721
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18492890
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16008644
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15078517
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.14231829
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13436256
85Pancreatic cancer_Homo sapiens_hsa052120.10775107
86Viral carcinogenesis_Homo sapiens_hsa052030.10051549
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.09719980
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08950183
89MAPK signaling pathway_Homo sapiens_hsa040100.08498288
90Prolactin signaling pathway_Homo sapiens_hsa049170.05450859
91Oxidative phosphorylation_Homo sapiens_hsa001900.05313467
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.04685072
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03396856
94Olfactory transduction_Homo sapiens_hsa047400.02539022
95HIF-1 signaling pathway_Homo sapiens_hsa040660.02243983
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01799457
97GnRH signaling pathway_Homo sapiens_hsa049120.01080196
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.01011551
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0184412
100Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0032502

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