ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.02252631
2	L-fucose catabolic process (GO:0042355)	4.57995764
3	fucose catabolic process (GO:0019317)	4.57995764
4	L-fucose metabolic process (GO:0042354)	4.57995764
5	response to pheromone (GO:0019236)	4.25415052
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.07822235
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.01909412
8	tryptophan catabolic process (GO:0006569)	3.93500967
9	indole-containing compound catabolic process (GO:0042436)	3.93500967
10	indolalkylamine catabolic process (GO:0046218)	3.93500967
11	piRNA metabolic process (GO:0034587)	3.81838959
12	indolalkylamine metabolic process (GO:0006586)	3.78634865
13	DNA deamination (GO:0045006)	3.70750953
14	negative regulation of telomere maintenance (GO:0032205)	3.70226843
15	kynurenine metabolic process (GO:0070189)	3.67590848
16	cellular ketone body metabolic process (GO:0046950)	3.66933447
17	protein polyglutamylation (GO:0018095)	3.63628162
18	epithelial cilium movement (GO:0003351)	3.56927473
19	tryptophan metabolic process (GO:0006568)	3.52912264
20	respiratory chain complex IV assembly (GO:0008535)	3.52051247
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.51853584
22	platelet dense granule organization (GO:0060155)	3.48326882
23	axoneme assembly (GO:0035082)	3.45134894
24	protein complex biogenesis (GO:0070271)	3.43820353
25	detection of light stimulus involved in visual perception (GO:0050908)	3.39085509
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.39085509
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35233184
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35233184
29	NADH dehydrogenase complex assembly (GO:0010257)	3.35233184
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.29781962
31	ketone body metabolic process (GO:1902224)	3.28821096
32	regulation of cilium movement (GO:0003352)	3.26780771
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.22345450
34	mannosylation (GO:0097502)	3.10777755
35	amine catabolic process (GO:0009310)	3.07562949
36	cellular biogenic amine catabolic process (GO:0042402)	3.07562949
37	multicellular organism reproduction (GO:0032504)	3.07283932
38	cytochrome complex assembly (GO:0017004)	3.05062916
39	DNA methylation involved in gamete generation (GO:0043046)	3.04403477
40	regulation of action potential (GO:0098900)	2.99029561
41	protein localization to cilium (GO:0061512)	2.98080188
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.93472935
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.93472935
44	cilium morphogenesis (GO:0060271)	2.92695289
45	male meiosis (GO:0007140)	2.88451194
46	indole-containing compound metabolic process (GO:0042430)	2.87980703
47	cornea development in camera-type eye (GO:0061303)	2.87521113
48	nephron tubule morphogenesis (GO:0072078)	2.86347321
49	nephron epithelium morphogenesis (GO:0072088)	2.86347321
50	negative regulation of mast cell activation (GO:0033004)	2.84855925
51	neuronal action potential (GO:0019228)	2.84854705
52	nonmotile primary cilium assembly (GO:0035058)	2.82583033
53	ubiquinone biosynthetic process (GO:0006744)	2.80920343
54	cilium movement (GO:0003341)	2.80389875
55	retinal cone cell development (GO:0046549)	2.79642889
56	protein-cofactor linkage (GO:0018065)	2.77026540
57	DNA double-strand break processing (GO:0000729)	2.74646339
58	gamma-aminobutyric acid transport (GO:0015812)	2.72464228
59	behavioral response to ethanol (GO:0048149)	2.71708439
60	regulation of hexokinase activity (GO:1903299)	2.70248459
61	regulation of glucokinase activity (GO:0033131)	2.70248459
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70173617
63	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.69971181
64	fucosylation (GO:0036065)	2.69723313
65	reflex (GO:0060004)	2.69574302
66	neural tube formation (GO:0001841)	2.68614479
67	sperm motility (GO:0030317)	2.68130661
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.67571411
69	kidney morphogenesis (GO:0060993)	2.66566909
70	ubiquinone metabolic process (GO:0006743)	2.63258877
71	GPI anchor metabolic process (GO:0006505)	2.62612463
72	S-adenosylmethionine metabolic process (GO:0046500)	2.61935606
73	cilium organization (GO:0044782)	2.60622912
74	synapsis (GO:0007129)	2.58531922
75	photoreceptor cell maintenance (GO:0045494)	2.56575484
76	photoreceptor cell development (GO:0042461)	2.56025170
77	synaptic transmission, cholinergic (GO:0007271)	2.54603166
78	sulfation (GO:0051923)	2.52694114
79	cilium assembly (GO:0042384)	2.52447476
80	L-methionine salvage (GO:0071267)	2.51530413
81	L-methionine biosynthetic process (GO:0071265)	2.51530413
82	amino acid salvage (GO:0043102)	2.51530413
83	positive regulation of fatty acid transport (GO:2000193)	2.48950270
84	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.48433184
85	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.48053672
86	reciprocal DNA recombination (GO:0035825)	2.45395408
87	reciprocal meiotic recombination (GO:0007131)	2.45395408
88	alanine transport (GO:0032328)	2.45354377
89	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.45287717
90	cilium or flagellum-dependent cell motility (GO:0001539)	2.44995940
91	dopamine transport (GO:0015872)	2.43285761
92	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.42481418
93	centriole replication (GO:0007099)	2.42304771
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.42202884
95	somite development (GO:0061053)	2.42070634
96	regulation of telomere maintenance (GO:0032204)	2.41567058
97	regulation of microtubule-based movement (GO:0060632)	2.40357114
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.40242597
99	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.39354303
100	neuronal action potential propagation (GO:0019227)	2.39154428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.12237184
2	VDR_22108803_ChIP-Seq_LS180_Human	3.26949483
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.02279415
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.96163620
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.82398277
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48737820
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46559399
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30371837
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26352136
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23033407
11	FUS_26573619_Chip-Seq_HEK293_Human	2.22058552
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20413080
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19905646
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.17572491
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16295874
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07312533
17	EWS_26573619_Chip-Seq_HEK293_Human	2.02900492
18	P300_19829295_ChIP-Seq_ESCs_Human	1.96075676
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.94711473
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91214546
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.87828749
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76965499
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75455662
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71281728
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69640517
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66585461
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66262319
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63328149
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.57367697
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57367697
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55655795
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.54052226
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.53617082
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52748156
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.52708604
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50940829
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50701943
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49590048
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45778450
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45020920
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45020920
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.43997551
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43052501
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42778013
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42778013
46	STAT3_23295773_ChIP-Seq_U87_Human	1.42567941
47	AR_25329375_ChIP-Seq_VCAP_Human	1.41088206
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40106174
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37119679
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37113633
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35754238
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34326627
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34039584
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33956429
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33956429
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33411366
57	TCF4_23295773_ChIP-Seq_U87_Human	1.33044758
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32348633
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31986579
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31461556
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29001927
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27673047
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27397638
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25864834
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25224949
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24337615
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23843524
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.23457946
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23169201
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19402462
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18555988
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18319258
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17148602
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17038718
75	NCOR_22424771_ChIP-Seq_293T_Human	1.16977838
76	AR_20517297_ChIP-Seq_VCAP_Human	1.16565354
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15429963
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13980961
79	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13083747
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13027547
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11290690
82	VDR_23849224_ChIP-Seq_CD4+_Human	1.09971892
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05122673
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05026647
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.03308999
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02417921
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01252273
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00410104
89	AR_21572438_ChIP-Seq_LNCaP_Human	1.00245089
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98498280
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98290111
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97501827
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.97243683
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96711708
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95429084
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94870131
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94368885
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93729263
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92063222
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91809940

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.99400629
2	MP0003136_yellow_coat_color	2.81221434
3	MP0002102_abnormal_ear_morphology	2.58985637
4	MP0001968_abnormal_touch/_nociception	2.43880307
5	MP0005551_abnormal_eye_electrophysiolog	2.39139332
6	MP0003195_calcinosis	2.33126780
7	MP0006072_abnormal_retinal_apoptosis	2.31641078
8	MP0002837_dystrophic_cardiac_calcinosis	2.30966848
9	MP0008875_abnormal_xenobiotic_pharmacok	2.25288191
10	MP0003880_abnormal_central_pattern	2.22817983
11	MP0005646_abnormal_pituitary_gland	2.19332221
12	MP0003646_muscle_fatigue	2.11489193
13	MP0000372_irregular_coat_pigmentation	2.10581193
14	MP0005645_abnormal_hypothalamus_physiol	2.00325302
15	MP0000569_abnormal_digit_pigmentation	1.97039159
16	MP0006292_abnormal_olfactory_placode	1.95132403
17	MP0008872_abnormal_physiological_respon	1.92787008
18	MP0009745_abnormal_behavioral_response	1.90408528
19	MP0002736_abnormal_nociception_after	1.89373026
20	MP0002876_abnormal_thyroid_physiology	1.85609479
21	MP0001986_abnormal_taste_sensitivity	1.84614564
22	MP0009046_muscle_twitch	1.83268413
23	MP0005253_abnormal_eye_physiology	1.79580094
24	MP0006276_abnormal_autonomic_nervous	1.74095252
25	MP0002638_abnormal_pupillary_reflex	1.73085280
26	MP0004885_abnormal_endolymph	1.72748158
27	MP0004142_abnormal_muscle_tone	1.71255704
28	MP0002272_abnormal_nervous_system	1.69852856
29	MP0004147_increased_porphyrin_level	1.67750056
30	MP0003787_abnormal_imprinting	1.65447325
31	MP0001984_abnormal_olfaction	1.64988372
32	MP0001501_abnormal_sleep_pattern	1.61030375
33	MP0001485_abnormal_pinna_reflex	1.60094523
34	MP0004133_heterotaxia	1.59150855
35	MP0005410_abnormal_fertilization	1.48878367
36	MP0004043_abnormal_pH_regulation	1.48804804
37	MP0000427_abnormal_hair_cycle	1.45904751
38	MP0000631_abnormal_neuroendocrine_gland	1.44477118
39	MP0004145_abnormal_muscle_electrophysio	1.44309428
40	MP0002938_white_spotting	1.42081157
41	MP0001529_abnormal_vocalization	1.39248140
42	MP0001486_abnormal_startle_reflex	1.36824534
43	MP0003011_delayed_dark_adaptation	1.34935001
44	MP0002735_abnormal_chemical_nociception	1.34897241
45	MP0008995_early_reproductive_senescence	1.34305390
46	MP0005174_abnormal_tail_pigmentation	1.34166036
47	MP0003718_maternal_effect	1.32127444
48	MP0002064_seizures	1.27653102
49	MP0002163_abnormal_gland_morphology	1.26426001
50	MP0002572_abnormal_emotion/affect_behav	1.25441871
51	MP0002557_abnormal_social/conspecific_i	1.25340568
52	MP0002733_abnormal_thermal_nociception	1.24894507
53	MP0005379_endocrine/exocrine_gland_phen	1.22989890
54	MP0005084_abnormal_gallbladder_morpholo	1.22644232
55	MP0002234_abnormal_pharynx_morphology	1.21422378
56	MP0002160_abnormal_reproductive_system	1.21300455
57	MP0002653_abnormal_ependyma_morphology	1.20565021
58	MP0001970_abnormal_pain_threshold	1.20540207
59	MP0005389_reproductive_system_phenotype	1.18891760
60	MP0008775_abnormal_heart_ventricle	1.17977419
61	MP0005167_abnormal_blood-brain_barrier	1.17885654
62	MP0008789_abnormal_olfactory_epithelium	1.15003478
63	MP0001905_abnormal_dopamine_level	1.09859667
64	MP0004742_abnormal_vestibular_system	1.07754094
65	MP0004215_abnormal_myocardial_fiber	1.06268915
66	MP0002928_abnormal_bile_duct	1.03675412
67	MP0002734_abnormal_mechanical_nocicepti	1.03461625
68	MP0003635_abnormal_synaptic_transmissio	1.02226801
69	MP0002277_abnormal_respiratory_mucosa	1.01110251
70	MP0004924_abnormal_behavior	1.00771797
71	MP0005386_behavior/neurological_phenoty	1.00771797
72	MP0003698_abnormal_male_reproductive	1.00437718
73	MP0002067_abnormal_sensory_capabilities	0.99776735
74	MP0002138_abnormal_hepatobiliary_system	0.99247628
75	MP0005187_abnormal_penis_morphology	0.96650493
76	MP0008058_abnormal_DNA_repair	0.96250529
77	MP0005195_abnormal_posterior_eye	0.96127163
78	MP0000647_abnormal_sebaceous_gland	0.92337174
79	MP0002063_abnormal_learning/memory/cond	0.91355395
80	MP0001929_abnormal_gametogenesis	0.91340539
81	MP0000230_abnormal_systemic_arterial	0.91018845
82	MP0001919_abnormal_reproductive_system	0.90194726
83	MP0001963_abnormal_hearing_physiology	0.88624564
84	MP0002095_abnormal_skin_pigmentation	0.86655666
85	MP0000383_abnormal_hair_follicle	0.84873560
86	MP0002909_abnormal_adrenal_gland	0.84697470
87	MP0002210_abnormal_sex_determination	0.84267413
88	MP0000026_abnormal_inner_ear	0.84168380
89	MP0002752_abnormal_somatic_nervous	0.84090898
90	MP0002254_reproductive_system_inflammat	0.82878672
91	MP0005075_abnormal_melanosome_morpholog	0.82171844
92	MP0002229_neurodegeneration	0.81511583
93	MP0001764_abnormal_homeostasis	0.80568182
94	MP0005332_abnormal_amino_acid	0.79491580
95	MP0005394_taste/olfaction_phenotype	0.78374765
96	MP0005499_abnormal_olfactory_system	0.78374765
97	MP0003786_premature_aging	0.78043975
98	MP0002751_abnormal_autonomic_nervous	0.76406677
99	MP0002184_abnormal_innervation	0.76112355
100	MP0003283_abnormal_digestive_organ	0.75947050

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.56515968
2	Pancreatic fibrosis (HP:0100732)	4.29194453
3	Abnormality of midbrain morphology (HP:0002418)	4.25653169
4	Molar tooth sign on MRI (HP:0002419)	4.25653169
5	Congenital stationary night blindness (HP:0007642)	3.97267382
6	True hermaphroditism (HP:0010459)	3.92208436
7	Nephronophthisis (HP:0000090)	3.64252703
8	Type II lissencephaly (HP:0007260)	3.56078977
9	Abnormality of the renal cortex (HP:0011035)	3.34942800
10	Abnormality of the renal medulla (HP:0100957)	3.24201595
11	Cystic liver disease (HP:0006706)	2.91251229
12	Medial flaring of the eyebrow (HP:0010747)	2.85536794
13	Chronic hepatic failure (HP:0100626)	2.78186279
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.77031213
15	Attenuation of retinal blood vessels (HP:0007843)	2.70089330
16	Tubular atrophy (HP:0000092)	2.66124838
17	Polydipsia (HP:0001959)	2.65885119
18	Abnormal drinking behavior (HP:0030082)	2.65885119
19	Abolished electroretinogram (ERG) (HP:0000550)	2.62683520
20	Renal cortical cysts (HP:0000803)	2.61631585
21	Large for gestational age (HP:0001520)	2.58182962
22	Absent/shortened dynein arms (HP:0200106)	2.54689286
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.54689286
24	Inability to walk (HP:0002540)	2.54401253
25	Abnormal biliary tract physiology (HP:0012439)	2.50251344
26	Bile duct proliferation (HP:0001408)	2.50251344
27	Sclerocornea (HP:0000647)	2.45223953
28	Hyperventilation (HP:0002883)	2.43443401
29	Cerebellar dysplasia (HP:0007033)	2.42810978
30	Mitochondrial inheritance (HP:0001427)	2.38562772
31	Congenital, generalized hypertrichosis (HP:0004540)	2.37641068
32	Increased CSF lactate (HP:0002490)	2.36082644
33	Abnormal respiratory epithelium morphology (HP:0012253)	2.31466446
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31466446
35	3-Methylglutaconic aciduria (HP:0003535)	2.30378508
36	Acute necrotizing encephalopathy (HP:0006965)	2.29354130
37	Pendular nystagmus (HP:0012043)	2.28654904
38	Lissencephaly (HP:0001339)	2.23814542
39	Gait imbalance (HP:0002141)	2.20369302
40	Anencephaly (HP:0002323)	2.19255231
41	Congenital hepatic fibrosis (HP:0002612)	2.17990673
42	Methylmalonic acidemia (HP:0002912)	2.17460947
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17088288
44	Abnormality of alanine metabolism (HP:0010916)	2.17088288
45	Hyperalaninemia (HP:0003348)	2.17088288
46	Hypothermia (HP:0002045)	2.16403861
47	Acute encephalopathy (HP:0006846)	2.15218485
48	Polyuria (HP:0000103)	2.13313288
49	Congenital primary aphakia (HP:0007707)	2.12744039
50	Hepatocellular necrosis (HP:0001404)	2.12098899
51	Severe muscular hypotonia (HP:0006829)	2.10302016
52	Increased corneal curvature (HP:0100692)	2.08204547
53	Keratoconus (HP:0000563)	2.08204547
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08033689
55	Progressive macrocephaly (HP:0004481)	2.07845874
56	Male pseudohermaphroditism (HP:0000037)	2.07651645
57	Gaze-evoked nystagmus (HP:0000640)	2.07516933
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06656310
59	Furrowed tongue (HP:0000221)	2.06259958
60	Concave nail (HP:0001598)	2.05098808
61	Hemiparesis (HP:0001269)	2.04824522
62	Nephrogenic diabetes insipidus (HP:0009806)	2.04454597
63	Optic nerve hypoplasia (HP:0000609)	2.03284014
64	Hepatic necrosis (HP:0002605)	2.03081241
65	Broad-based gait (HP:0002136)	2.02689443
66	Febrile seizures (HP:0002373)	2.02573365
67	Occipital encephalocele (HP:0002085)	2.01888259
68	Hyperglycinuria (HP:0003108)	2.01152804
69	Lipid accumulation in hepatocytes (HP:0006561)	2.01113265
70	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99080758
71	Abnormal ciliary motility (HP:0012262)	1.98533794
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97526878
73	Decreased central vision (HP:0007663)	1.96535634
74	Optic disc pallor (HP:0000543)	1.96083345
75	Progressive inability to walk (HP:0002505)	1.95891202
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95689423
77	Retinal dysplasia (HP:0007973)	1.95125810
78	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95050447
79	Abnormality of the pons (HP:0007361)	1.94133146
80	Postaxial foot polydactyly (HP:0001830)	1.93302240
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93139548
82	Intestinal atresia (HP:0011100)	1.90102303
83	Focal motor seizures (HP:0011153)	1.88164338
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85434829
85	Pachygyria (HP:0001302)	1.84361161
86	Hyperglycinemia (HP:0002154)	1.84051498
87	Methylmalonic aciduria (HP:0012120)	1.83759823
88	Abnormality of the labia minora (HP:0012880)	1.82921697
89	Abnormality of macular pigmentation (HP:0008002)	1.82489178
90	Genital tract atresia (HP:0001827)	1.81103251
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.81006178
92	Decreased circulating renin level (HP:0003351)	1.80719068
93	Short tibia (HP:0005736)	1.78098262
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77541875
95	Abnormality of glycine metabolism (HP:0010895)	1.77541875
96	Postaxial hand polydactyly (HP:0001162)	1.77281923
97	Hypoplasia of the pons (HP:0012110)	1.74157823
98	Vaginal atresia (HP:0000148)	1.73324475
99	Fair hair (HP:0002286)	1.73286506
100	Hypomagnesemia (HP:0002917)	1.72977614

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.04400292
2	MAP4K2	3.42217786
3	PINK1	3.27515763
4	ADRBK2	2.97419758
5	BMPR1B	2.83780989
6	NUAK1	2.78979743
7	ZAK	2.71410975
8	INSRR	2.36194692
9	WNK4	2.34677358
10	TLK1	2.34328906
11	WNK3	2.31625876
12	GRK1	2.12010891
13	TAOK3	2.06565591
14	ACVR1B	2.06140981
15	MAPK13	1.82092887
16	OXSR1	1.75678733
17	CASK	1.71903031
18	TXK	1.65357773
19	STK39	1.56263875
20	DAPK2	1.40853598
21	TRIM28	1.35060607
22	MAP3K4	1.28475081
23	TNIK	1.28314108
24	MAP2K6	1.26543093
25	PLK2	1.26001098
26	PAK3	1.18637429
27	PHKG2	1.09492792
28	PHKG1	1.09492792
29	DYRK2	1.09080896
30	TIE1	1.08760683
31	BCKDK	1.06480581
32	EIF2AK3	1.05076419
33	VRK1	1.02762729
34	MST4	1.01323704
35	PRKCE	0.98733612
36	MUSK	0.97848046
37	ADRBK1	0.97260973
38	CSNK1G2	0.96558454
39	MKNK2	0.96364080
40	MAPKAPK3	0.95251931
41	PNCK	0.95198425
42	CSNK1G1	0.94300348
43	PRKCG	0.92329499
44	MARK1	0.91783559
45	CSNK1G3	0.91325173
46	MAPKAPK5	0.89083035
47	CAMKK2	0.89060938
48	TGFBR1	0.88681043
49	BCR	0.86968525
50	ERBB3	0.85406711
51	PTK2B	0.81856477
52	STK38L	0.74091044
53	CSNK1A1L	0.74034674
54	FGFR2	0.73905218
55	MAP2K7	0.72385545
56	OBSCN	0.71300719
57	MAPK15	0.71132274
58	NME1	0.68177264
59	RPS6KA5	0.66941422
60	PRKCQ	0.65716481
61	PLK3	0.65537275
62	FLT3	0.64410468
63	PRKCI	0.64267574
64	PLK4	0.63431378
65	PIK3CA	0.56500709
66	VRK2	0.56225780
67	TAF1	0.55875388
68	NTRK3	0.54713461
69	KIT	0.54188090
70	MARK3	0.53477545
71	TEC	0.53119374
72	CAMK2A	0.53099810
73	STK16	0.52076276
74	TSSK6	0.48591227
75	EPHA4	0.47186367
76	WEE1	0.46992619
77	IRAK1	0.46581245
78	IKBKB	0.46462905
79	NTRK2	0.46337135
80	MKNK1	0.45639174
81	CAMK1	0.45550227
82	CSNK1A1	0.44357252
83	PRKACA	0.43767733
84	PKN1	0.42142578
85	FER	0.40183088
86	BRSK2	0.39747176
87	CSNK1D	0.38600231
88	TNK2	0.38542186
89	CCNB1	0.37972492
90	STK11	0.36706741
91	STK3	0.36081615
92	PRKG1	0.34521836
93	PRKCA	0.33269348
94	CDK19	0.31764565
95	CDK3	0.31536701
96	PRKAA1	0.31502001
97	CHUK	0.30485381
98	GRK5	0.29938373
99	NLK	0.29307288
100	PRKACB	0.27776061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.64829483
2	Phototransduction_Homo sapiens_hsa04744	2.61808212
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.58544548
4	Butanoate metabolism_Homo sapiens_hsa00650	2.57749218
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43568654
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.43368299
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38292146
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37176540
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.30051208
10	Caffeine metabolism_Homo sapiens_hsa00232	2.28404954
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24116830
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02616077
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.90287587
14	Nicotine addiction_Homo sapiens_hsa05033	1.87011360
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86868386
16	Parkinsons disease_Homo sapiens_hsa05012	1.85151522
17	Protein export_Homo sapiens_hsa03060	1.84087839
18	Basal transcription factors_Homo sapiens_hsa03022	1.83111109
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.83003723
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.79045981
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76122516
22	RNA polymerase_Homo sapiens_hsa03020	1.71391441
23	Propanoate metabolism_Homo sapiens_hsa00640	1.70414476
24	Homologous recombination_Homo sapiens_hsa03440	1.68916745
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.66023484
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54526899
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51073308
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39961028
29	Taste transduction_Homo sapiens_hsa04742	1.30561479
30	One carbon pool by folate_Homo sapiens_hsa00670	1.28844899
31	RNA degradation_Homo sapiens_hsa03018	1.28743162
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27488312
33	Olfactory transduction_Homo sapiens_hsa04740	1.24866383
34	Huntingtons disease_Homo sapiens_hsa05016	1.22754325
35	Peroxisome_Homo sapiens_hsa04146	1.20785847
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.20776842
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20415792
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16890653
39	Alzheimers disease_Homo sapiens_hsa05010	1.16560922
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11314422
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07660810
42	Morphine addiction_Homo sapiens_hsa05032	1.05657259
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03018149
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02948474
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02617632
46	Proteasome_Homo sapiens_hsa03050	0.97568582
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92169332
48	Retinol metabolism_Homo sapiens_hsa00830	0.90620511
49	Insulin secretion_Homo sapiens_hsa04911	0.90036024
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89295544
51	Sulfur metabolism_Homo sapiens_hsa00920	0.89214439
52	Asthma_Homo sapiens_hsa05310	0.89140879
53	Regulation of autophagy_Homo sapiens_hsa04140	0.88485443
54	GABAergic synapse_Homo sapiens_hsa04727	0.86982410
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86564888
56	ABC transporters_Homo sapiens_hsa02010	0.85397843
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83344170
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82981779
59	Circadian entrainment_Homo sapiens_hsa04713	0.80988611
60	Purine metabolism_Homo sapiens_hsa00230	0.80982373
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80761825
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79879028
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.76445249
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75197079
65	Metabolic pathways_Homo sapiens_hsa01100	0.72171722
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.71162107
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70345122
68	Serotonergic synapse_Homo sapiens_hsa04726	0.69612926
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.69466667
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68293411
71	Salivary secretion_Homo sapiens_hsa04970	0.68080355
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67654561
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.65089006
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.59177701
75	Fatty acid degradation_Homo sapiens_hsa00071	0.57801664
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56228354
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56172623
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53968629
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53113269
80	Mineral absorption_Homo sapiens_hsa04978	0.51960951
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51521336
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.51468179
83	Circadian rhythm_Homo sapiens_hsa04710	0.50174790
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47026385
85	Fatty acid elongation_Homo sapiens_hsa00062	0.45978002
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.45524054
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42953164
88	Histidine metabolism_Homo sapiens_hsa00340	0.40787293
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39986964
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39734658
91	Allograft rejection_Homo sapiens_hsa05330	0.39270072
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38122167
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37801509
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36104631
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35742168
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.35196184
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34281630
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32633597
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31496200
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30480278

C1ORF167

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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