ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	8.86058898
2	axonemal dynein complex assembly (GO:0070286)	8.09775174
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.70949426
4	cilium movement (GO:0003341)	7.65615252
5	epithelial cilium movement (GO:0003351)	6.98522693
6	axoneme assembly (GO:0035082)	6.00470652
7	motile cilium assembly (GO:0044458)	5.60153494
8	regulation of cilium movement (GO:0003352)	4.72958809
9	exogenous drug catabolic process (GO:0042738)	4.42019394
10	intraciliary transport (GO:0042073)	4.41697911
11	drug catabolic process (GO:0042737)	4.41440016
12	cilium organization (GO:0044782)	4.25274899
13	protein localization to cilium (GO:0061512)	4.19079443
14	cilium assembly (GO:0042384)	4.13886791
15	cellular ketone body metabolic process (GO:0046950)	4.04486895
16	left/right axis specification (GO:0070986)	3.92334493
17	ketone body metabolic process (GO:1902224)	3.78950512
18	cilium morphogenesis (GO:0060271)	3.70994988
19	photoreceptor cell maintenance (GO:0045494)	3.63007410
20	tryptophan catabolic process (GO:0006569)	3.51511992
21	indole-containing compound catabolic process (GO:0042436)	3.51511992
22	indolalkylamine catabolic process (GO:0046218)	3.51511992
23	indolalkylamine metabolic process (GO:0006586)	3.43551096
24	cellular component assembly involved in morphogenesis (GO:0010927)	3.40412736
25	nonmotile primary cilium assembly (GO:0035058)	3.40269444
26	microtubule bundle formation (GO:0001578)	3.27954686
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.26869746
28	retinal cone cell development (GO:0046549)	3.21562841
29	left/right pattern formation (GO:0060972)	3.14488993
30	oxidative demethylation (GO:0070989)	3.14042203
31	tryptophan metabolic process (GO:0006568)	3.13409441
32	aromatic amino acid family catabolic process (GO:0009074)	3.13210703
33	ventricular system development (GO:0021591)	3.05477395
34	reflex (GO:0060004)	3.01390470
35	diterpenoid biosynthetic process (GO:0016102)	2.97301550
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.95392667
37	detection of light stimulus involved in visual perception (GO:0050908)	2.95392667
38	benzene-containing compound metabolic process (GO:0042537)	2.95322715
39	epoxygenase P450 pathway (GO:0019373)	2.93276145
40	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.91346307
41	phenylpropanoid metabolic process (GO:0009698)	2.84286301
42	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.83828677
43	kynurenine metabolic process (GO:0070189)	2.83638429
44	ethanol metabolic process (GO:0006067)	2.82293536
45	bile acid biosynthetic process (GO:0006699)	2.79261550
46	negative regulation of humoral immune response (GO:0002921)	2.78866483
47	respiratory chain complex IV assembly (GO:0008535)	2.78746775
48	determination of left/right symmetry (GO:0007368)	2.75542951
49	retinol metabolic process (GO:0042572)	2.71247813
50	glutathione derivative biosynthetic process (GO:1901687)	2.70689644
51	glutathione derivative metabolic process (GO:1901685)	2.70689644
52	negative regulation of protein activation cascade (GO:2000258)	2.70601703
53	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.70121754
54	L-phenylalanine catabolic process (GO:0006559)	2.70121754
55	cornea development in camera-type eye (GO:0061303)	2.69764017
56	cell projection assembly (GO:0030031)	2.68594424
57	ethanol oxidation (GO:0006069)	2.68449710
58	protein polyglutamylation (GO:0018095)	2.68367824
59	negative regulation of complement activation (GO:0045916)	2.68194605
60	drug metabolic process (GO:0017144)	2.66885497
61	thyroid hormone metabolic process (GO:0042403)	2.66309930
62	response to pheromone (GO:0019236)	2.65118052
63	smoothened signaling pathway (GO:0007224)	2.64834708
64	righting reflex (GO:0060013)	2.61694164
65	signal peptide processing (GO:0006465)	2.61630805
66	determination of bilateral symmetry (GO:0009855)	2.61529559
67	centriole replication (GO:0007099)	2.61216525
68	amine catabolic process (GO:0009310)	2.59157249
69	cellular biogenic amine catabolic process (GO:0042402)	2.59157249
70	regulation of microtubule-based movement (GO:0060632)	2.58631382
71	vitamin transmembrane transport (GO:0035461)	2.58372039
72	flavonoid metabolic process (GO:0009812)	2.58287630
73	indole-containing compound metabolic process (GO:0042430)	2.56787423
74	aromatic amino acid family metabolic process (GO:0009072)	2.56719987
75	S-adenosylmethionine metabolic process (GO:0046500)	2.55560338
76	regulation of hexokinase activity (GO:1903299)	2.55042378
77	regulation of glucokinase activity (GO:0033131)	2.55042378
78	specification of symmetry (GO:0009799)	2.54147411
79	centriole assembly (GO:0098534)	2.53862198
80	sperm motility (GO:0030317)	2.50783875
81	retinoic acid metabolic process (GO:0042573)	2.50745361
82	dopamine transport (GO:0015872)	2.50598238
83	nephron tubule morphogenesis (GO:0072078)	2.49088518
84	nephron epithelium morphogenesis (GO:0072088)	2.49088518
85	omega-hydroxylase P450 pathway (GO:0097267)	2.48275794
86	terpenoid biosynthetic process (GO:0016114)	2.47055129
87	response to nitrosative stress (GO:0051409)	2.46043027
88	positive regulation of glycolytic process (GO:0045821)	2.42016483
89	primary alcohol catabolic process (GO:0034310)	2.40358762
90	regulation of acrosome reaction (GO:0060046)	2.40350605
91	organic cation transport (GO:0015695)	2.40013915
92	xenobiotic catabolic process (GO:0042178)	2.39296386
93	water-soluble vitamin biosynthetic process (GO:0042364)	2.39163751
94	cytochrome complex assembly (GO:0017004)	2.36806701
95	regulation of collateral sprouting (GO:0048670)	2.36692637
96	photoreceptor cell development (GO:0042461)	2.34323893
97	appendage development (GO:0048736)	2.33377934
98	limb development (GO:0060173)	2.33377934
99	microtubule-based movement (GO:0007018)	2.31938160
100	auditory receptor cell stereocilium organization (GO:0060088)	2.31410488

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	2.94784808
2	VDR_22108803_ChIP-Seq_LS180_Human	2.93328923
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.83435702
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.65461113
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53073436
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47608423
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46764840
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35644386
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25551149
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24980411
11	* PIAS1_25552417_ChIP-Seq_VCAP_Human	2.18806342
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16786644
13	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.13848813
14	FUS_26573619_Chip-Seq_HEK293_Human	2.08850523
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.08664745
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.08258020
17	* P300_19829295_ChIP-Seq_ESCs_Human	2.00857900
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95458130
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92991537
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.92553571
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89971411
22	STAT3_23295773_ChIP-Seq_U87_Human	1.80227460
23	EWS_26573619_Chip-Seq_HEK293_Human	1.79241030
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.76948703
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.76621480
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72629229
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68400281
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.60106778
29	* TCF4_23295773_ChIP-Seq_U87_Human	1.59970991
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59496707
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.58200854
32	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57311958
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.57127930
34	AR_25329375_ChIP-Seq_VCAP_Human	1.56760807
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.55929061
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54259949
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.54005706
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54005706
39	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.53401624
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52012393
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.51717146
42	* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.51054673
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50795218
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.49605214
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48459309
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47293960
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46899499
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41285264
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39828589
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39084628
51	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.35823778
52	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.34504350
53	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.34504350
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33963714
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33815295
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33815295
57	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.33037803
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32283303
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30483560
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30464364
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28892686
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28257181
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27088735
64	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.26087077
65	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23255012
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23128735
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.22829528
68	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.21729940
69	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21524790
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18722036
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18552132
72	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18396987
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17391838
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15095262
75	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13546076
76	TP53_16413492_ChIP-PET_HCT116_Human	1.13471678
77	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13458742
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13043952
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12922100
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12594199
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12594199
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12525112
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10843883
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10099731
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10064062
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09870519
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09360970
88	* TBL1_22424771_ChIP-Seq_293T_Human	1.09095833
89	* PHF8_20622853_ChIP-Seq_HELA_Human	1.09054030
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07083205
91	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.06582608
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05501141
93	AR_20517297_ChIP-Seq_VCAP_Human	1.05449049
94	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05400578
95	TP53_18474530_ChIP-ChIP_U2OS_Human	1.05293722
96	AR_21572438_ChIP-Seq_LNCaP_Human	1.04364862
97	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.04237952
98	* NFYB_21822215_ChIP-Seq_K562_Human	1.04112326
99	P300_18555785_Chip-Seq_ESCs_Mouse	1.03677459
100	TP53_22573176_ChIP-Seq_HFKS_Human	1.03563404

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.38196722
2	MP0008875_abnormal_xenobiotic_pharmacok	3.18306405
3	MP0004043_abnormal_pH_regulation	2.63720004
4	MP0001984_abnormal_olfaction	2.50555394
5	MP0005551_abnormal_eye_electrophysiolog	2.45976722
6	MP0002139_abnormal_hepatobiliary_system	2.43705618
7	MP0002876_abnormal_thyroid_physiology	2.41886510
8	MP0002653_abnormal_ependyma_morphology	2.40824497
9	MP0005646_abnormal_pituitary_gland	2.37757546
10	MP0002837_dystrophic_cardiac_calcinosis	2.37648607
11	MP0009780_abnormal_chondrocyte_physiolo	2.21098311
12	MP0003011_delayed_dark_adaptation	2.10917555
13	MP0003136_yellow_coat_color	1.97457819
14	MP0000372_irregular_coat_pigmentation	1.92020416
15	MP0005085_abnormal_gallbladder_physiolo	1.90696060
16	MP0005365_abnormal_bile_salt	1.89882766
17	MP0005253_abnormal_eye_physiology	1.88795248
18	MP0006072_abnormal_retinal_apoptosis	1.88612003
19	MP0009046_muscle_twitch	1.83891738
20	MP0004133_heterotaxia	1.82901936
21	MP0000383_abnormal_hair_follicle	1.76019649
22	MP0002638_abnormal_pupillary_reflex	1.75145420
23	MP0005645_abnormal_hypothalamus_physiol	1.72249075
24	MP0001501_abnormal_sleep_pattern	1.67610089
25	MP0000631_abnormal_neuroendocrine_gland	1.66218751
26	MP0003252_abnormal_bile_duct	1.66016543
27	MP0002138_abnormal_hepatobiliary_system	1.61878440
28	MP0005379_endocrine/exocrine_gland_phen	1.59646007
29	MP0002909_abnormal_adrenal_gland	1.54332358
30	MP0002102_abnormal_ear_morphology	1.51143936
31	MP0004019_abnormal_vitamin_homeostasis	1.50095198
32	MP0008872_abnormal_physiological_respon	1.49189430
33	MP0000427_abnormal_hair_cycle	1.47611429
34	MP0002938_white_spotting	1.46720425
35	MP0006292_abnormal_olfactory_placode	1.45782759
36	MP0002928_abnormal_bile_duct	1.44021561
37	MP0000569_abnormal_digit_pigmentation	1.42832018
38	MP0008877_abnormal_DNA_methylation	1.41925585
39	MP0009745_abnormal_behavioral_response	1.38011427
40	MP0001968_abnormal_touch/_nociception	1.37572116
41	MP0004142_abnormal_muscle_tone	1.36176470
42	MP0002163_abnormal_gland_morphology	1.35129310
43	MP0005332_abnormal_amino_acid	1.35055714
44	MP0010678_abnormal_skin_adnexa	1.30142084
45	MP0003878_abnormal_ear_physiology	1.29508750
46	MP0005377_hearing/vestibular/ear_phenot	1.29508750
47	MP0004215_abnormal_myocardial_fiber	1.28254304
48	MP0006276_abnormal_autonomic_nervous	1.26337562
49	MP0008789_abnormal_olfactory_epithelium	1.23790059
50	MP0000566_synostosis	1.23488587
51	MP0001764_abnormal_homeostasis	1.22896055
52	MP0001486_abnormal_startle_reflex	1.22419800
53	MP0010386_abnormal_urinary_bladder	1.21854222
54	MP0010329_abnormal_lipoprotein_level	1.20181858
55	MP0001485_abnormal_pinna_reflex	1.17592128
56	MP0002168_other_aberrant_phenotype	1.17147653
57	MP0002736_abnormal_nociception_after	1.16510290
58	MP0002277_abnormal_respiratory_mucosa	1.11266265
59	MP0001666_abnormal_nutrient_absorption	1.09600629
60	MP0001944_abnormal_pancreas_morphology	1.07637654
61	MP0003646_muscle_fatigue	1.07262982
62	MP0005670_abnormal_white_adipose	1.06945019
63	MP0002132_abnormal_respiratory_system	1.06893705
64	MP0005636_abnormal_mineral_homeostasis	1.06740463
65	MP0005395_other_phenotype	1.04303285
66	MP0002272_abnormal_nervous_system	1.04096473
67	MP0005220_abnormal_exocrine_pancreas	1.00730889
68	MP0003718_maternal_effect	0.99686630
69	MP0002160_abnormal_reproductive_system	0.99397918
70	MP0002282_abnormal_trachea_morphology	0.99012335
71	MP0005195_abnormal_posterior_eye	0.98226243
72	MP0001324_abnormal_eye_pigmentation	0.98106882
73	MP0002693_abnormal_pancreas_physiology	0.96191385
74	MP0002557_abnormal_social/conspecific_i	0.95595619
75	MP0003283_abnormal_digestive_organ	0.95152227
76	MP0005360_urolithiasis	0.94392372
77	MP0005248_abnormal_Harderian_gland	0.93456388
78	MP0002234_abnormal_pharynx_morphology	0.93434359
79	MP0002734_abnormal_mechanical_nocicepti	0.93182933
80	MP0005084_abnormal_gallbladder_morpholo	0.89667708
81	MP0003880_abnormal_central_pattern	0.89502673
82	MP0003868_abnormal_feces_composition	0.88029866
83	MP0004085_abnormal_heartbeat	0.87543916
84	MP0002229_neurodegeneration	0.87472006
85	MP0001756_abnormal_urination	0.87232426
86	MP0002078_abnormal_glucose_homeostasis	0.85688082
87	MP0002572_abnormal_emotion/affect_behav	0.84331109
88	MP0005187_abnormal_penis_morphology	0.84231192
89	MP0002064_seizures	0.83213787
90	MP0001765_abnormal_ion_homeostasis	0.82215122
91	MP0008995_early_reproductive_senescence	0.81987203
92	MP0005389_reproductive_system_phenotype	0.80284730
93	MP0004924_abnormal_behavior	0.79113105
94	MP0005386_behavior/neurological_phenoty	0.79113105
95	MP0003698_abnormal_male_reproductive	0.77927967
96	MP0002090_abnormal_vision	0.77345018
97	MP0003943_abnormal_hepatobiliary_system	0.77201081
98	MP0001529_abnormal_vocalization	0.75421739
99	MP0003137_abnormal_impulse_conducting	0.75339691
100	MP0005391_vision/eye_phenotype	0.74408393

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	7.05265016
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.05265016
3	Abnormal ciliary motility (HP:0012262)	6.83136421
4	Abnormal respiratory epithelium morphology (HP:0012253)	6.77808778
5	Abnormal respiratory motile cilium morphology (HP:0005938)	6.77808778
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.61748100
7	Abnormal respiratory motile cilium physiology (HP:0012261)	6.48424023
8	Rhinitis (HP:0012384)	5.92608806
9	Pancreatic fibrosis (HP:0100732)	4.82449019
10	True hermaphroditism (HP:0010459)	4.73050435
11	Pancreatic cysts (HP:0001737)	4.57439499
12	Bronchiectasis (HP:0002110)	4.22391993
13	Abnormality of midbrain morphology (HP:0002418)	3.86911473
14	Molar tooth sign on MRI (HP:0002419)	3.86911473
15	Chronic bronchitis (HP:0004469)	3.81201981
16	Nephronophthisis (HP:0000090)	3.60381413
17	Cystic liver disease (HP:0006706)	3.57099947
18	Medial flaring of the eyebrow (HP:0010747)	3.40366887
19	Chronic hepatic failure (HP:0100626)	3.33503728
20	Abnormality of the renal medulla (HP:0100957)	3.12803694
21	Congenital primary aphakia (HP:0007707)	2.91456810
22	Gait imbalance (HP:0002141)	2.89051744
23	Abnormality of the renal cortex (HP:0011035)	2.80267089
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.78309447
25	Occipital encephalocele (HP:0002085)	2.65809678
26	Nephrogenic diabetes insipidus (HP:0009806)	2.64777853
27	Tubular atrophy (HP:0000092)	2.63301751
28	Postaxial foot polydactyly (HP:0001830)	2.63268170
29	Genital tract atresia (HP:0001827)	2.62763854
30	Congenital hepatic fibrosis (HP:0002612)	2.61600447
31	Chronic sinusitis (HP:0011109)	2.51607557
32	Male pseudohermaphroditism (HP:0000037)	2.50965042
33	Congenital stationary night blindness (HP:0007642)	2.50547697
34	Vaginal atresia (HP:0000148)	2.50217294
35	Furrowed tongue (HP:0000221)	2.48397415
36	Anencephaly (HP:0002323)	2.42921835
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.42152452
38	Sclerocornea (HP:0000647)	2.42089893
39	Decreased central vision (HP:0007663)	2.36800813
40	Decreased circulating renin level (HP:0003351)	2.28655289
41	Attenuation of retinal blood vessels (HP:0007843)	2.27902667
42	Polydipsia (HP:0001959)	2.27703072
43	Abnormal drinking behavior (HP:0030082)	2.27703072
44	Abolished electroretinogram (ERG) (HP:0000550)	2.24223004
45	Infertility (HP:0000789)	2.21964168
46	Tubulointerstitial nephritis (HP:0001970)	2.18695743
47	Abnormality of macular pigmentation (HP:0008002)	2.17699943
48	Postaxial hand polydactyly (HP:0001162)	2.17649527
49	Gaze-evoked nystagmus (HP:0000640)	2.16470334
50	Hyperventilation (HP:0002883)	2.16194698
51	Nasal polyposis (HP:0100582)	2.10973226
52	Recurrent sinusitis (HP:0011108)	2.08594163
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.08281163
54	Bronchitis (HP:0012387)	2.08004052
55	Poor coordination (HP:0002370)	2.01329628
56	Tubulointerstitial abnormality (HP:0001969)	2.00866128
57	Ketoacidosis (HP:0001993)	1.98265002
58	Chronic otitis media (HP:0000389)	1.98183821
59	Bile duct proliferation (HP:0001408)	1.97740898
60	Abnormal biliary tract physiology (HP:0012439)	1.97740898
61	Large for gestational age (HP:0001520)	1.96147261
62	Hypothermia (HP:0002045)	1.93199076
63	Intestinal atresia (HP:0011100)	1.93148266
64	Congenital sensorineural hearing impairment (HP:0008527)	1.87523746
65	Hyperactive renin-angiotensin system (HP:0000841)	1.83587943
66	Severe visual impairment (HP:0001141)	1.83003083
67	Ketosis (HP:0001946)	1.80400931
68	Tubulointerstitial fibrosis (HP:0005576)	1.79944398
69	Preaxial hand polydactyly (HP:0001177)	1.76136648
70	Retinitis pigmentosa (HP:0000510)	1.75468965
71	Oculomotor apraxia (HP:0000657)	1.74343287
72	Fair hair (HP:0002286)	1.72610883
73	Median cleft lip (HP:0000161)	1.72400623
74	Polyuria (HP:0000103)	1.72299621
75	Renal cortical cysts (HP:0000803)	1.71048797
76	Supernumerary spleens (HP:0009799)	1.69507119
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67702472
78	Methylmalonic acidemia (HP:0002912)	1.66039242
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.65608501
80	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.64076373
81	Central scotoma (HP:0000603)	1.63701854
82	Asplenia (HP:0001746)	1.63284056
83	Abnormality of renin-angiotensin system (HP:0000847)	1.60199697
84	Absent speech (HP:0001344)	1.59630438
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.56898955
86	Prolonged partial thromboplastin time (HP:0003645)	1.55707170
87	Constricted visual fields (HP:0001133)	1.54968674
88	Abnormality of the fovea (HP:0000493)	1.54794470
89	Hypoglycemic coma (HP:0001325)	1.53077811
90	Increased corneal curvature (HP:0100692)	1.51888881
91	Keratoconus (HP:0000563)	1.51888881
92	Disproportionate short-trunk short stature (HP:0003521)	1.51022075
93	Proximal tubulopathy (HP:0000114)	1.51000109
94	Multicystic kidney dysplasia (HP:0000003)	1.50855996
95	Narrow forehead (HP:0000341)	1.50640187
96	Progressive cerebellar ataxia (HP:0002073)	1.49772391
97	Male infertility (HP:0003251)	1.49458994
98	Left ventricular hypertrophy (HP:0001712)	1.48389016
99	Astigmatism (HP:0000483)	1.48122056
100	Prominent nasal bridge (HP:0000426)	1.47363610

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.60005793
2	MAPK15	2.71196285
3	MST4	2.56291655
4	BMPR1B	2.53894491
5	ACVR1B	2.53470542
6	WNK3	2.51273757
7	ADRBK2	2.38413117
8	CASK	2.33924841
9	INSRR	2.29944831
10	FGFR2	2.26831975
11	GRK1	2.13236496
12	TNIK	2.00818486
13	MAP3K4	1.94984861
14	PINK1	1.94387960
15	MAP4K2	1.88597733
16	STK39	1.71416782
17	STK38L	1.63136465
18	BRSK2	1.61223860
19	OXSR1	1.60858394
20	NUAK1	1.49450718
21	NTRK3	1.39114849
22	WNK4	1.36659787
23	TRIM28	1.35668871
24	PRKCE	1.30345208
25	MAP3K12	1.26800401
26	MAPK13	1.26722483
27	EPHA3	1.21430074
28	PAK3	1.20346121
29	ZAK	1.15388254
30	PNCK	1.15043712
31	NLK	1.12403117
32	MKNK2	1.11529961
33	PIK3CG	1.07366202
34	EPHA4	1.03733955
35	PTK2B	1.02685928
36	IRAK1	0.98333007
37	BCR	0.89348210
38	OBSCN	0.89290815
39	DAPK2	0.88657786
40	ERBB3	0.88021923
41	AKT3	0.87906766
42	PRKAA2	0.87394210
43	FER	0.86900490
44	PHKG2	0.86668185
45	PHKG1	0.86668185
46	PRKCG	0.84660360
47	MAP3K7	0.83749067
48	STK3	0.83382088
49	MAP2K6	0.81652637
50	MAP3K2	0.81636554
51	PLK2	0.80658773
52	ADRBK1	0.80213520
53	TNK2	0.79138694
54	EIF2AK3	0.77817845
55	TRPM7	0.70751371
56	TAOK3	0.68481369
57	MAPKAPK3	0.68399824
58	MUSK	0.67599154
59	TLK1	0.67416959
60	NME1	0.65835646
61	PIK3CA	0.63425910
62	MAP2K7	0.63201741
63	PKN1	0.62670355
64	STK24	0.56854373
65	PRKACA	0.55236567
66	MYLK	0.54461334
67	CAMK2A	0.53427578
68	PRKAA1	0.52875696
69	FGFR3	0.52433664
70	CSNK1G1	0.51731347
71	PRKG1	0.50372555
72	CAMK1G	0.50192968
73	STK11	0.50098631
74	TEC	0.49748631
75	SGK2	0.49366836
76	TGFBR1	0.45870715
77	CDK3	0.45774236
78	CAMKK2	0.44078157
79	PRKCI	0.44071140
80	LMTK2	0.43729517
81	MAP2K4	0.43202910
82	SGK1	0.43045747
83	CAMK1	0.41200120
84	CSNK1A1	0.38863651
85	CSNK1G2	0.38064575
86	PLK3	0.37758734
87	PDK2	0.37496648
88	PRKCA	0.37257776
89	PRKACB	0.35317312
90	CSNK1A1L	0.35195028
91	MARK1	0.34413912
92	ROCK1	0.33957748
93	CHUK	0.33562378
94	PRKCZ	0.32995293
95	PRKCQ	0.32198458
96	PLK1	0.31886385
97	CSNK1G3	0.31444388
98	CAMK2D	0.31238780
99	DYRK2	0.30567450
100	TTK	0.30004580

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.04697084
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.79523494
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.77928170
4	Caffeine metabolism_Homo sapiens_hsa00232	2.74639935
5	Butanoate metabolism_Homo sapiens_hsa00650	2.67578287
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.67550941
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.64444664
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.48143696
9	Retinol metabolism_Homo sapiens_hsa00830	2.40200921
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33096141
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.28291430
12	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.11510198
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.03655056
14	Histidine metabolism_Homo sapiens_hsa00340	2.01992072
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98370665
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.90688765
17	ABC transporters_Homo sapiens_hsa02010	1.90400552
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88194486
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86993162
20	Propanoate metabolism_Homo sapiens_hsa00640	1.81898428
21	Phototransduction_Homo sapiens_hsa04744	1.71541883
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70582695
23	Fatty acid degradation_Homo sapiens_hsa00071	1.55130188
24	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.54728106
25	Peroxisome_Homo sapiens_hsa04146	1.54448767
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.49234380
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44351509
28	Complement and coagulation cascades_Homo sapiens_hsa04610	1.43677027
29	Tyrosine metabolism_Homo sapiens_hsa00350	1.37055537
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36346374
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.29305043
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.24813163
33	Circadian rhythm_Homo sapiens_hsa04710	1.24688456
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.21838860
35	Protein export_Homo sapiens_hsa03060	1.12308472
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.09686758
37	Nicotine addiction_Homo sapiens_hsa05033	1.09582796
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08953716
39	Insulin secretion_Homo sapiens_hsa04911	1.08414528
40	Huntingtons disease_Homo sapiens_hsa05016	1.07220681
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07104072
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06222410
43	Glutathione metabolism_Homo sapiens_hsa00480	1.05368987
44	Sphingolipid metabolism_Homo sapiens_hsa00600	1.04998063
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.99508822
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97302537
47	Olfactory transduction_Homo sapiens_hsa04740	0.94643901
48	Taste transduction_Homo sapiens_hsa04742	0.89939771
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.88947547
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88438426
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88239280
52	Sulfur metabolism_Homo sapiens_hsa00920	0.87799175
53	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86614354
54	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.84404337
55	Serotonergic synapse_Homo sapiens_hsa04726	0.83939458
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81478310
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79655331
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76634698
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76212993
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74512190
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.74444349
62	Homologous recombination_Homo sapiens_hsa03440	0.73346402
63	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.71096307
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.70290809
65	Metabolic pathways_Homo sapiens_hsa01100	0.69848068
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69306584
67	Bile secretion_Homo sapiens_hsa04976	0.68991849
68	Arginine biosynthesis_Homo sapiens_hsa00220	0.67715188
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65328582
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.65132553
71	Salivary secretion_Homo sapiens_hsa04970	0.64138522
72	Basal transcription factors_Homo sapiens_hsa03022	0.63791617
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63215149
74	Regulation of autophagy_Homo sapiens_hsa04140	0.62314967
75	Mineral absorption_Homo sapiens_hsa04978	0.61071784
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57577417
77	One carbon pool by folate_Homo sapiens_hsa00670	0.55181971
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.54195418
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54100007
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53361186
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53158698
82	Morphine addiction_Homo sapiens_hsa05032	0.52513468
83	Circadian entrainment_Homo sapiens_hsa04713	0.51204703
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48188610
85	GABAergic synapse_Homo sapiens_hsa04727	0.48043990
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46699492
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42876851
88	Pancreatic secretion_Homo sapiens_hsa04972	0.40573712
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40353566
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39983672
91	Parkinsons disease_Homo sapiens_hsa05012	0.39910223
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.39853557
93	Folate biosynthesis_Homo sapiens_hsa00790	0.39429485
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.39412641
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39340850
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38056496
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36711744
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35931795
99	Lysine degradation_Homo sapiens_hsa00310	0.35133667
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.34848853

C1ORF168

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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