ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.62559906
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.38799697
3	protein complex biogenesis (GO:0070271)	4.37501621
4	NADH dehydrogenase complex assembly (GO:0010257)	4.29851923
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.29851923
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.29851923
7	respiratory chain complex IV assembly (GO:0008535)	4.23704929
8	mitochondrial respiratory chain complex assembly (GO:0033108)	4.21360000
9	proteasome assembly (GO:0043248)	3.94260559
10	cytochrome complex assembly (GO:0017004)	3.80157370
11	platelet dense granule organization (GO:0060155)	3.76189479
12	cullin deneddylation (GO:0010388)	3.64962913
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.62201042
14	protein K6-linked ubiquitination (GO:0085020)	3.59442609
15	protein deneddylation (GO:0000338)	3.57627546
16	DNA double-strand break processing (GO:0000729)	3.46190816
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.39691109
18	protein-cofactor linkage (GO:0018065)	3.39385642
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38265251
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.34924427
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.34924427
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32317264
23	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.29475858
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28828987
25	rRNA modification (GO:0000154)	3.24967346
26	ATP synthesis coupled proton transport (GO:0015986)	3.22683865
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.22683865
28	protein neddylation (GO:0045116)	3.22482944
29	recombinational repair (GO:0000725)	3.15691437
30	replication fork processing (GO:0031297)	3.14882481
31	double-strand break repair via homologous recombination (GO:0000724)	3.12466601
32	synapsis (GO:0007129)	3.10603817
33	negative regulation of telomere maintenance (GO:0032205)	3.10555872
34	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.09039837
35	regulation of DNA endoreduplication (GO:0032875)	3.05816453
36	mannosylation (GO:0097502)	3.04653709
37	preassembly of GPI anchor in ER membrane (GO:0016254)	3.02244247
38	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.01707163
39	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.01707163
40	response to pheromone (GO:0019236)	3.01254921
41	piRNA metabolic process (GO:0034587)	2.92594666
42	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.92540658
43	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.92282090
44	termination of RNA polymerase III transcription (GO:0006386)	2.90319740
45	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.90319740
46	chromatin remodeling at centromere (GO:0031055)	2.89221358
47	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.88400219
48	isotype switching (GO:0045190)	2.88400219
49	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.88400219
50	electron transport chain (GO:0022900)	2.87725601
51	pseudouridine synthesis (GO:0001522)	2.87448279
52	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.87434010
53	peptidyl-histidine modification (GO:0018202)	2.86790282
54	respiratory electron transport chain (GO:0022904)	2.86776216
55	lactate metabolic process (GO:0006089)	2.85494639
56	regulation of meiosis I (GO:0060631)	2.83501031
57	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.83020608
58	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.83020608
59	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.83020608
60	DNA catabolic process, exonucleolytic (GO:0000738)	2.82909703
61	adenosine metabolic process (GO:0046085)	2.82886447
62	positive regulation of histone H3-K4 methylation (GO:0051571)	2.82410090
63	rRNA methylation (GO:0031167)	2.78142731
64	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76780992
65	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76780992
66	negative regulation of ligase activity (GO:0051352)	2.76411784
67	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.76411784
68	sulfation (GO:0051923)	2.76383162
69	maturation of 5.8S rRNA (GO:0000460)	2.76305612
70	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.76094161
71	CENP-A containing nucleosome assembly (GO:0034080)	2.75410733
72	regulation of mitotic spindle checkpoint (GO:1903504)	2.72905364
73	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.72905364
74	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.72504387
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.70631106
76	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.70027763
77	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.70027763
78	neuron fate determination (GO:0048664)	2.69984516
79	cytidine metabolic process (GO:0046087)	2.66766176
80	cytidine catabolic process (GO:0006216)	2.66766176
81	cytidine deamination (GO:0009972)	2.66766176
82	chaperone-mediated protein transport (GO:0072321)	2.64545595
83	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.63682323
84	regulation of hexokinase activity (GO:1903299)	2.63166384
85	regulation of glucokinase activity (GO:0033131)	2.63166384
86	tRNA processing (GO:0008033)	2.62129887
87	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.61622690
88	cellular ketone body metabolic process (GO:0046950)	2.61433476
89	histone exchange (GO:0043486)	2.61329260
90	centriole replication (GO:0007099)	2.60305978
91	L-fucose catabolic process (GO:0042355)	2.59307131
92	fucose catabolic process (GO:0019317)	2.59307131
93	L-fucose metabolic process (GO:0042354)	2.59307131
94	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.57558874
95	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.56806657
96	DNA replication-dependent nucleosome assembly (GO:0006335)	2.55319663
97	DNA replication-dependent nucleosome organization (GO:0034723)	2.55319663
98	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53716962
99	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.53457418
100	S-adenosylmethionine metabolic process (GO:0046500)	2.53346967

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35749102
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.81324877
3	* EST1_17652178_ChIP-ChIP_JURKAT_Human	3.67021290
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.14063158
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09861051
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07621062
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.89889355
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.76647214
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.74562208
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73748324
11	VDR_22108803_ChIP-Seq_LS180_Human	2.64135594
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53132421
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.49153284
14	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.49058847
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.32261518
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15987520
17	E2F7_22180533_ChIP-Seq_HELA_Human	2.13294799
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.12924237
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12266201
20	EWS_26573619_Chip-Seq_HEK293_Human	2.03176006
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97207427
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96356046
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93971623
24	FUS_26573619_Chip-Seq_HEK293_Human	1.92321904
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90978838
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.88451471
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83513286
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.83072098
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78897638
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.74086399
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.72309705
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69939039
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68471040
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.62563005
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62468754
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.62107491
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61513959
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.59350631
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.58951754
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53808728
41	P300_19829295_ChIP-Seq_ESCs_Human	1.50350954
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47751345
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.47239360
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42554183
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.36812292
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.36348443
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32125645
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.30640108
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27607187
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26720852
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26306849
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26126285
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26126285
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25846288
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.25215500
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23869012
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21884401
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21884401
59	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21468660
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.19950333
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.16840887
62	IGF1R_20145208_ChIP-Seq_DFB_Human	1.16766567
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13753262
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12011529
65	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.09064834
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08816094
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.08816094
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07259579
69	* BCAT_22108803_ChIP-Seq_LS180_Human	1.05937832
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05742632
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05013045
72	AR_20517297_ChIP-Seq_VCAP_Human	1.04612424
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04433371
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04342150
75	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03763606
76	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01257122
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00325836
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00281874
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98901081
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98563822
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.97016943
82	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96813728
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96542863
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93677372
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93471708
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.92765133
87	NCOR_22424771_ChIP-Seq_293T_Human	0.92024416
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91673074
89	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91330092
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.89516409
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89164756
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87771001
93	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.86468742
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.86135509
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86014424
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85172856
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.85033982
98	* PHF8_20622853_ChIP-Seq_HELA_Human	0.84231770
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.84052273
100	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.83504096

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.98902836
2	MP0008058_abnormal_DNA_repair	3.30358595
3	MP0003195_calcinosis	2.72038071
4	MP0006072_abnormal_retinal_apoptosis	2.54980281
5	MP0002102_abnormal_ear_morphology	2.48665920
6	MP0006292_abnormal_olfactory_placode	2.46910293
7	MP0003693_abnormal_embryo_hatching	2.45818394
8	MP0000372_irregular_coat_pigmentation	2.40811035
9	MP0010094_abnormal_chromosome_stability	2.38235209
10	MP0003786_premature_aging	2.20902790
11	MP0005084_abnormal_gallbladder_morpholo	2.19777853
12	MP0002138_abnormal_hepatobiliary_system	2.17631723
13	MP0002163_abnormal_gland_morphology	2.17522164
14	MP0003718_maternal_effect	2.00933483
15	MP0002938_white_spotting	1.95509550
16	MP0003787_abnormal_imprinting	1.89889241
17	MP0003806_abnormal_nucleotide_metabolis	1.80554769
18	MP0005379_endocrine/exocrine_gland_phen	1.78339144
19	MP0002837_dystrophic_cardiac_calcinosis	1.77015899
20	MP0003111_abnormal_nucleus_morphology	1.75000329
21	MP0008872_abnormal_physiological_respon	1.74827756
22	MP0008007_abnormal_cellular_replicative	1.72748732
23	MP0008995_early_reproductive_senescence	1.71702788
24	MP0006036_abnormal_mitochondrial_physio	1.71665768
25	MP0005253_abnormal_eye_physiology	1.70476262
26	MP0001529_abnormal_vocalization	1.63618572
27	MP0005551_abnormal_eye_electrophysiolog	1.61489757
28	MP0005410_abnormal_fertilization	1.60818887
29	MP0008057_abnormal_DNA_replication	1.60300784
30	MP0003121_genomic_imprinting	1.55445460
31	MP0004147_increased_porphyrin_level	1.52471079
32	MP0008789_abnormal_olfactory_epithelium	1.51773510
33	MP0005645_abnormal_hypothalamus_physiol	1.51555359
34	MP0001485_abnormal_pinna_reflex	1.46929771
35	MP0002638_abnormal_pupillary_reflex	1.45435515
36	MP0006035_abnormal_mitochondrial_morpho	1.43105955
37	MP0003011_delayed_dark_adaptation	1.39970570
38	MP0004142_abnormal_muscle_tone	1.36646413
39	MP0003077_abnormal_cell_cycle	1.35445035
40	MP0002928_abnormal_bile_duct	1.34916979
41	MP0001929_abnormal_gametogenesis	1.33624405
42	MP0001764_abnormal_homeostasis	1.32705384
43	MP0005075_abnormal_melanosome_morpholog	1.29887879
44	MP0009697_abnormal_copulation	1.28951423
45	MP0002160_abnormal_reproductive_system	1.27412269
46	MP0005646_abnormal_pituitary_gland	1.27336532
47	MP0000631_abnormal_neuroendocrine_gland	1.25675644
48	MP0001968_abnormal_touch/_nociception	1.24515900
49	MP0005389_reproductive_system_phenotype	1.24401035
50	MP0003122_maternal_imprinting	1.22252702
51	MP0004957_abnormal_blastocyst_morpholog	1.20445478
52	MP0004133_heterotaxia	1.19669485
53	MP0002210_abnormal_sex_determination	1.18807298
54	MP0003136_yellow_coat_color	1.14784199
55	MP0000516_abnormal_urinary_system	1.14005642
56	MP0005367_renal/urinary_system_phenotyp	1.14005642
57	MP0000653_abnormal_sex_gland	1.12915199
58	MP0005671_abnormal_response_to	1.07643197
59	MP0009046_muscle_twitch	1.07303467
60	MP0003186_abnormal_redox_activity	1.07019110
61	MP0003698_abnormal_male_reproductive	1.06715414
62	MP0002277_abnormal_respiratory_mucosa	1.06492943
63	MP0002736_abnormal_nociception_after	1.06116385
64	MP0001145_abnormal_male_reproductive	1.04942700
65	MP0002653_abnormal_ependyma_morphology	1.04353799
66	MP0001984_abnormal_olfaction	0.98064703
67	MP0003646_muscle_fatigue	0.97911945
68	MP0008875_abnormal_xenobiotic_pharmacok	0.96584789
69	MP0005499_abnormal_olfactory_system	0.95271328
70	MP0005394_taste/olfaction_phenotype	0.95271328
71	MP0005174_abnormal_tail_pigmentation	0.93817389
72	MP0005636_abnormal_mineral_homeostasis	0.92063375
73	MP0000647_abnormal_sebaceous_gland	0.91785694
74	MP0001119_abnormal_female_reproductive	0.89673919
75	MP0006054_spinal_hemorrhage	0.89454803
76	MP0002693_abnormal_pancreas_physiology	0.89181126
77	MP0006276_abnormal_autonomic_nervous	0.88876877
78	MP0001293_anophthalmia	0.88709338
79	MP0003252_abnormal_bile_duct	0.87914660
80	MP0001919_abnormal_reproductive_system	0.87431223
81	MP0001905_abnormal_dopamine_level	0.85220176
82	MP0002095_abnormal_skin_pigmentation	0.84641680
83	MP0000613_abnormal_salivary_gland	0.84627695
84	MP0005332_abnormal_amino_acid	0.83016142
85	MP0002272_abnormal_nervous_system	0.81608530
86	MP0002751_abnormal_autonomic_nervous	0.80992501
87	MP0001944_abnormal_pancreas_morphology	0.76866701
88	MP0002876_abnormal_thyroid_physiology	0.76775742
89	MP0005195_abnormal_posterior_eye	0.76269224
90	MP0003937_abnormal_limbs/digits/tail_de	0.76015505
91	MP0008932_abnormal_embryonic_tissue	0.72178386
92	MP0000358_abnormal_cell_content/	0.71451283
93	MP0005395_other_phenotype	0.69933465
94	MP0000015_abnormal_ear_pigmentation	0.67858112
95	MP0000569_abnormal_digit_pigmentation	0.67696205
96	MP0003119_abnormal_digestive_system	0.67051598
97	MP0009745_abnormal_behavioral_response	0.66252820
98	MP0004134_abnormal_chest_morphology	0.66014175
99	MP0000383_abnormal_hair_follicle	0.62823991
100	MP0001324_abnormal_eye_pigmentation	0.62624152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.87723896
2	Pancreatic cysts (HP:0001737)	3.68606427
3	Progressive macrocephaly (HP:0004481)	3.48865102
4	Mitochondrial inheritance (HP:0001427)	3.47802133
5	Pancreatic fibrosis (HP:0100732)	3.43526567
6	Acute encephalopathy (HP:0006846)	3.35662697
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.34499654
8	Methylmalonic acidemia (HP:0002912)	3.31301806
9	Increased CSF lactate (HP:0002490)	3.25738126
10	True hermaphroditism (HP:0010459)	3.21731922
11	Congenital stationary night blindness (HP:0007642)	3.18659262
12	Hepatocellular necrosis (HP:0001404)	3.01347013
13	Molar tooth sign on MRI (HP:0002419)	3.00167177
14	Abnormality of midbrain morphology (HP:0002418)	3.00167177
15	Hepatic necrosis (HP:0002605)	2.86556491
16	Methylmalonic aciduria (HP:0012120)	2.86176305
17	Increased hepatocellular lipid droplets (HP:0006565)	2.63610745
18	Abnormality of the labia minora (HP:0012880)	2.58598481
19	Colon cancer (HP:0003003)	2.53402149
20	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.46460068
21	Abnormality of the renal cortex (HP:0011035)	2.45115150
22	Pendular nystagmus (HP:0012043)	2.44473382
23	Cerebral edema (HP:0002181)	2.44145381
24	Lipid accumulation in hepatocytes (HP:0006561)	2.43823539
25	Nephronophthisis (HP:0000090)	2.42608262
26	Abolished electroretinogram (ERG) (HP:0000550)	2.42168682
27	3-Methylglutaconic aciduria (HP:0003535)	2.42054255
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39899729
29	Meckel diverticulum (HP:0002245)	2.38533409
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.37411476
31	Optic disc pallor (HP:0000543)	2.36032653
32	Abnormality of the ileum (HP:0001549)	2.34812893
33	Chromsome breakage (HP:0040012)	2.34668246
34	Volvulus (HP:0002580)	2.33778481
35	Congenital, generalized hypertrichosis (HP:0004540)	2.31462398
36	Cystic liver disease (HP:0006706)	2.30671255
37	Abnormality of chromosome stability (HP:0003220)	2.27513445
38	Abnormality of the preputium (HP:0100587)	2.27128948
39	Sclerocornea (HP:0000647)	2.25841388
40	Medial flaring of the eyebrow (HP:0010747)	2.20623170
41	Abnormality of vitamin B metabolism (HP:0004340)	2.20083625
42	Increased serum lactate (HP:0002151)	2.18778098
43	Lactic acidosis (HP:0003128)	2.16644148
44	Renal Fanconi syndrome (HP:0001994)	2.14860624
45	Hypothermia (HP:0002045)	2.12146281
46	Abnormality of the renal medulla (HP:0100957)	2.11875709
47	Bile duct proliferation (HP:0001408)	2.11687487
48	Abnormal biliary tract physiology (HP:0012439)	2.11687487
49	Severe visual impairment (HP:0001141)	2.10064559
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07124540
51	Constricted visual fields (HP:0001133)	2.05567517
52	Abnormality of methionine metabolism (HP:0010901)	2.02971228
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02118079
54	Furrowed tongue (HP:0000221)	2.01013369
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99330960
56	Absent thumb (HP:0009777)	1.98146285
57	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96085807
58	Intestinal atresia (HP:0011100)	1.95853829
59	Short 1st metacarpal (HP:0010034)	1.94649688
60	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.94649688
61	Type I transferrin isoform profile (HP:0003642)	1.94551692
62	Attenuation of retinal blood vessels (HP:0007843)	1.94293198
63	Aplastic anemia (HP:0001915)	1.89634982
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89538530
65	Abnormal protein N-linked glycosylation (HP:0012347)	1.89538530
66	Abnormal protein glycosylation (HP:0012346)	1.89538530
67	Abnormal glycosylation (HP:0012345)	1.89538530
68	Adrenal hypoplasia (HP:0000835)	1.88858294
69	Stomach cancer (HP:0012126)	1.88460773
70	Respiratory failure (HP:0002878)	1.88315214
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.85671206
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.85671206
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.84586584
74	Abnormality of the duodenum (HP:0002246)	1.83944008
75	Small intestinal stenosis (HP:0012848)	1.83383605
76	Duodenal stenosis (HP:0100867)	1.83383605
77	Lethargy (HP:0001254)	1.82837328
78	Congenital hepatic fibrosis (HP:0002612)	1.82197422
79	Sloping forehead (HP:0000340)	1.82184514
80	Neoplasm of the adrenal cortex (HP:0100641)	1.81331548
81	Conjunctival hamartoma (HP:0100780)	1.80114957
82	Asplenia (HP:0001746)	1.79102612
83	Renal cortical cysts (HP:0000803)	1.78483252
84	Male pseudohermaphroditism (HP:0000037)	1.78471877
85	Small hand (HP:0200055)	1.77897503
86	Prostate neoplasm (HP:0100787)	1.77739538
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77382723
88	Exertional dyspnea (HP:0002875)	1.77129361
89	Hypoplasia of the uterus (HP:0000013)	1.77010822
90	Abnormality of the pons (HP:0007361)	1.76687915
91	Pancytopenia (HP:0001876)	1.76001561
92	Glycosuria (HP:0003076)	1.75118890
93	Abnormality of urine glucose concentration (HP:0011016)	1.75118890
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74648276
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73748847
96	Anencephaly (HP:0002323)	1.73117952
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72975166
98	Hypoplasia of the fovea (HP:0007750)	1.72975166
99	Abnormal drinking behavior (HP:0030082)	1.72006689
100	Polydipsia (HP:0001959)	1.72006689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.34498225
2	FRK	3.23615984
3	NUAK1	3.22844133
4	BUB1	3.03592972
5	ZAK	2.63498943
6	TRIM28	2.62991051
7	MST4	2.59571881
8	GRK1	2.49241178
9	TAF1	2.41963856
10	MAP4K2	2.37963102
11	ADRBK2	2.08252885
12	WNK3	2.03703510
13	PLK4	2.01912840
14	VRK1	2.00463314
15	MAP3K9	1.95780818
16	BMPR1B	1.93373870
17	BRSK2	1.86787847
18	MKNK2	1.86473900
19	PLK3	1.78497173
20	PINK1	1.73625357
21	PLK2	1.73247774
22	EIF2AK3	1.65783160
23	SRPK1	1.60010894
24	BCKDK	1.55893856
25	EIF2AK1	1.48971468
26	TNIK	1.47610329
27	INSRR	1.47172081
28	TSSK6	1.45316829
29	ACVR1B	1.37276653
30	MKNK1	1.35088722
31	NEK1	1.31377558
32	ERBB3	1.30163778
33	WEE1	1.27959061
34	CSNK1G3	1.20721441
35	CDC7	1.18666055
36	CSNK1G1	1.13073405
37	PASK	1.12147908
38	CASK	1.09881120
39	WNK4	1.08206652
40	TLK1	1.05585300
41	NME1	1.05246780
42	PLK1	0.98476565
43	CSNK1G2	0.98390377
44	TXK	0.97405181
45	TIE1	0.92282758
46	DYRK2	0.86681016
47	PAK3	0.86185746
48	TAOK3	0.85082601
49	PNCK	0.85000607
50	OXSR1	0.84542227
51	TTK	0.84187051
52	BCR	0.84145079
53	BRSK1	0.83769236
54	STK16	0.82612020
55	CSNK1A1L	0.82397875
56	MAPK13	0.78810461
57	FGFR2	0.72119464
58	ATR	0.69357032
59	SIK3	0.66879136
60	PBK	0.66415579
61	STK39	0.65144935
62	MAP3K4	0.63147890
63	PRKCI	0.62724953
64	CCNB1	0.62404654
65	CHEK2	0.61762315
66	STK38L	0.60828458
67	PRKCE	0.59916664
68	STK3	0.58391360
69	TGFBR1	0.55084053
70	EIF2AK2	0.53059537
71	DYRK3	0.52909042
72	MAPKAPK5	0.52420499
73	GRK7	0.51378291
74	IKBKB	0.49887064
75	MAP3K12	0.49466470
76	PTK2B	0.49303107
77	ATM	0.49145226
78	TEC	0.47818446
79	AURKB	0.46698758
80	AURKA	0.45148622
81	ADRBK1	0.42896472
82	MUSK	0.42330669
83	CSNK2A1	0.42077412
84	PIK3CG	0.41154201
85	FLT3	0.41047566
86	GRK5	0.40306803
87	PRKCG	0.38690535
88	MAP2K6	0.37896581
89	DAPK1	0.37290379
90	STK10	0.36915923
91	RPS6KA5	0.36578785
92	FER	0.35722545
93	PRKCQ	0.34120506
94	CSNK2A2	0.32654680
95	MAP2K7	0.32004082
96	CSNK1A1	0.30557564
97	RPS6KA4	0.30478628
98	PHKG2	0.29487552
99	PHKG1	0.29487552
100	CLK1	0.29324921

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.62846871
2	Protein export_Homo sapiens_hsa03060	3.55971226
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01170229
4	Homologous recombination_Homo sapiens_hsa03440	3.00984253
5	RNA polymerase_Homo sapiens_hsa03020	2.62948435
6	Parkinsons disease_Homo sapiens_hsa05012	2.43196048
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41702211
8	Mismatch repair_Homo sapiens_hsa03430	2.38245386
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.37461376
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35072828
11	Basal transcription factors_Homo sapiens_hsa03022	2.27229964
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.20637580
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.19908278
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.99470998
15	One carbon pool by folate_Homo sapiens_hsa00670	1.86112316
16	DNA replication_Homo sapiens_hsa03030	1.85985153
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.83724122
18	Propanoate metabolism_Homo sapiens_hsa00640	1.69002266
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68730671
20	Huntingtons disease_Homo sapiens_hsa05016	1.66917735
21	RNA degradation_Homo sapiens_hsa03018	1.66577994
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.59015610
23	Sulfur metabolism_Homo sapiens_hsa00920	1.57058249
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.53731754
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53712375
26	Butanoate metabolism_Homo sapiens_hsa00650	1.51590338
27	Alzheimers disease_Homo sapiens_hsa05010	1.50860490
28	Phototransduction_Homo sapiens_hsa04744	1.49661454
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49098351
30	Base excision repair_Homo sapiens_hsa03410	1.45890483
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.44490507
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.44430377
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40241160
34	RNA transport_Homo sapiens_hsa03013	1.38624134
35	Ribosome_Homo sapiens_hsa03010	1.34606031
36	Spliceosome_Homo sapiens_hsa03040	1.32394007
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32286160
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30463731
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22740486
40	Fatty acid elongation_Homo sapiens_hsa00062	1.18282985
41	Purine metabolism_Homo sapiens_hsa00230	1.12151869
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.10919779
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07765831
44	Peroxisome_Homo sapiens_hsa04146	1.05209874
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04938347
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.02791055
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96253218
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.94790936
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.91420663
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87902239
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86811248
52	Glutathione metabolism_Homo sapiens_hsa00480	0.85702812
53	Cell cycle_Homo sapiens_hsa04110	0.84909495
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84724780
55	Folate biosynthesis_Homo sapiens_hsa00790	0.84088343
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82631993
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81151740
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.80317545
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79602801
60	Metabolic pathways_Homo sapiens_hsa01100	0.75942305
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.74384472
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.73249904
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70667886
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70173424
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66578588
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62021667
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.61485546
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58484320
69	Regulation of autophagy_Homo sapiens_hsa04140	0.56728966
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56475975
71	Oocyte meiosis_Homo sapiens_hsa04114	0.54971318
72	Retinol metabolism_Homo sapiens_hsa00830	0.54833461
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53120163
74	Caffeine metabolism_Homo sapiens_hsa00232	0.51856441
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50288181
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48856137
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48799262
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48620431
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44579912
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42227414
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40289999
82	Olfactory transduction_Homo sapiens_hsa04740	0.39567397
83	p53 signaling pathway_Homo sapiens_hsa04115	0.39489867
84	Fatty acid degradation_Homo sapiens_hsa00071	0.37033611
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36882901
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.36133650
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35454287
88	Asthma_Homo sapiens_hsa05310	0.35125050
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35124236
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34664093
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32713445
92	Allograft rejection_Homo sapiens_hsa05330	0.31815971
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31561743
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.30258828
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.29164117
96	Sulfur relay system_Homo sapiens_hsa04122	0.28498846
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.27911707
98	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.26754904
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26436689
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26289219

C1ORF174

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »