ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.50122330
2	piRNA metabolic process (GO:0034587)	3.86533660
3	negative regulation of B cell apoptotic process (GO:0002903)	3.72015300
4	regulation of B cell apoptotic process (GO:0002902)	3.66703225
5	positive regulation of B cell differentiation (GO:0045579)	3.56802816
6	tryptophan catabolic process (GO:0006569)	3.46768538
7	indole-containing compound catabolic process (GO:0042436)	3.46768538
8	indolalkylamine catabolic process (GO:0046218)	3.46768538
9	definitive hemopoiesis (GO:0060216)	3.45274454
10	tryptophan metabolic process (GO:0006568)	3.40658895
11	platelet dense granule organization (GO:0060155)	3.39784070
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.35150131
13	cellular response to exogenous dsRNA (GO:0071360)	3.33420234
14	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.27410402
15	base-excision repair, AP site formation (GO:0006285)	3.26241273
16	indolalkylamine metabolic process (GO:0006586)	3.24321042
17	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.21096191
18	fucose catabolic process (GO:0019317)	3.20279498
19	L-fucose metabolic process (GO:0042354)	3.20279498
20	L-fucose catabolic process (GO:0042355)	3.20279498
21	response to protozoan (GO:0001562)	3.19230652
22	positive regulation of prostaglandin secretion (GO:0032308)	3.11667552
23	cytidine deamination (GO:0009972)	3.05383375
24	cytidine metabolic process (GO:0046087)	3.05383375
25	cytidine catabolic process (GO:0006216)	3.05383375
26	response to interferon-beta (GO:0035456)	3.02762048
27	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98521863
28	immunoglobulin mediated immune response (GO:0016064)	2.96367463
29	axoneme assembly (GO:0035082)	2.94183117
30	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.93680334
31	autophagic vacuole fusion (GO:0000046)	2.88991591
32	pyrimidine nucleotide catabolic process (GO:0006244)	2.84575138
33	deoxyribonucleotide catabolic process (GO:0009264)	2.80128139
34	DNA methylation involved in gamete generation (GO:0043046)	2.79743252
35	B cell receptor signaling pathway (GO:0050853)	2.72709897
36	positive regulation of defense response to virus by host (GO:0002230)	2.69567965
37	organelle membrane fusion (GO:0090174)	2.69480873
38	defense response to protozoan (GO:0042832)	2.69349553
39	positive regulation of granulocyte differentiation (GO:0030854)	2.68547145
40	deoxyribose phosphate catabolic process (GO:0046386)	2.67493103
41	regulation of B cell differentiation (GO:0045577)	2.64140454
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.63663518
43	neural tube formation (GO:0001841)	2.63413665
44	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.62842557
45	negative regulation of metanephros development (GO:0072217)	2.59086611
46	pseudouridine synthesis (GO:0001522)	2.59039778
47	mannosylation (GO:0097502)	2.58974514
48	positive regulation of icosanoid secretion (GO:0032305)	2.58339579
49	mast cell degranulation (GO:0043303)	2.57498409
50	mast cell activation involved in immune response (GO:0002279)	2.57498409
51	male meiosis I (GO:0007141)	2.56690968
52	S-adenosylmethionine metabolic process (GO:0046500)	2.55852969
53	GPI anchor metabolic process (GO:0006505)	2.53529946
54	amine catabolic process (GO:0009310)	2.52020857
55	cellular biogenic amine catabolic process (GO:0042402)	2.52020857
56	thrombin receptor signaling pathway (GO:0070493)	2.51721370
57	positive regulation of fatty acid transport (GO:2000193)	2.50705750
58	aromatic amino acid family catabolic process (GO:0009074)	2.50565173
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50253962
60	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.47641631
61	B cell mediated immunity (GO:0019724)	2.47229578
62	GPI anchor biosynthetic process (GO:0006506)	2.47099492
63	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.44665111
64	amino acid salvage (GO:0043102)	2.44442763
65	L-methionine salvage (GO:0071267)	2.44442763
66	L-methionine biosynthetic process (GO:0071265)	2.44442763
67	DNA dealkylation (GO:0035510)	2.44197971
68	cytokine biosynthetic process (GO:0042089)	2.43879667
69	parturition (GO:0007567)	2.42165584
70	kynurenine metabolic process (GO:0070189)	2.41417508
71	regulation of B cell receptor signaling pathway (GO:0050855)	2.39506384
72	protein complex biogenesis (GO:0070271)	2.39434820
73	seminiferous tubule development (GO:0072520)	2.38572919
74	mast cell activation (GO:0045576)	2.38503326
75	aggressive behavior (GO:0002118)	2.38106925
76	regulation of respiratory burst (GO:0060263)	2.37994758
77	tyrosine phosphorylation of STAT protein (GO:0007260)	2.37097792
78	nephron tubule formation (GO:0072079)	2.36560380
79	detection of light stimulus involved in visual perception (GO:0050908)	2.36366296
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.36366296
81	mature B cell differentiation involved in immune response (GO:0002313)	2.35713412
82	photoreceptor cell maintenance (GO:0045494)	2.35572430
83	branched-chain amino acid catabolic process (GO:0009083)	2.34626791
84	metallo-sulfur cluster assembly (GO:0031163)	2.34367712
85	iron-sulfur cluster assembly (GO:0016226)	2.34367712
86	DNA demethylation (GO:0080111)	2.34331274
87	response to pheromone (GO:0019236)	2.32972898
88	arginine catabolic process (GO:0006527)	2.32730595
89	B cell differentiation (GO:0030183)	2.31900854
90	positive regulation of megakaryocyte differentiation (GO:0045654)	2.31093565
91	positive regulation of histone H3-K4 methylation (GO:0051571)	2.30807782
92	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.30634570
93	ubiquinone biosynthetic process (GO:0006744)	2.30570625
94	regulation of prostaglandin secretion (GO:0032306)	2.30301789
95	cellular response to interferon-beta (GO:0035458)	2.29564194
96	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.29308581
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.29308581
98	NADH dehydrogenase complex assembly (GO:0010257)	2.29308581
99	NAD biosynthetic process (GO:0009435)	2.27055808
100	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.26157420

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.99005830
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.89649770
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60014374
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.04495020
5	VDR_22108803_ChIP-Seq_LS180_Human	2.89401162
6	SCL_19346495_ChIP-Seq_HPC-7_Human	2.60737200
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.60707450
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50528219
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42885756
10	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.16260416
11	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.14695598
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.07748433
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92045117
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88141783
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85944120
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.84366786
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.83404484
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.83390645
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.81674342
20	* GATA3_26560356_Chip-Seq_TH2_Human	1.67734812
21	MYB_26560356_Chip-Seq_TH2_Human	1.67540533
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55963786
23	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.53695307
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52620879
25	EWS_26573619_Chip-Seq_HEK293_Human	1.51678306
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.51574261
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.47432636
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46931098
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45373771
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.44068868
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42693034
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41475706
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40731327
34	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.39997435
35	AR_20517297_ChIP-Seq_VCAP_Human	1.39794173
36	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.39454140
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38328270
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37023768
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.37023768
40	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34438991
41	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34438991
42	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.33956498
43	CIITA_25753668_ChIP-Seq_RAJI_Human	1.32842515
44	GATA3_27048872_Chip-Seq_THYMUS_Human	1.32801154
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32524776
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31676105
47	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.31374766
48	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29698531
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26217806
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26217806
51	* SPI1_23547873_ChIP-Seq_NB4_Human	1.26200695
52	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.24788742
53	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22773099
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.21764899
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20496377
56	ERA_21632823_ChIP-Seq_H3396_Human	1.20067651
57	FUS_26573619_Chip-Seq_HEK293_Human	1.19869713
58	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18924897
59	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.18808266
60	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.17880286
61	P300_19829295_ChIP-Seq_ESCs_Human	1.16094611
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14593663
63	RUNX_20019798_ChIP-Seq_JUKART_Human	1.14014298
64	GBX2_23144817_ChIP-Seq_PC3_Human	1.13159202
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13036174
66	STAT1_20625510_ChIP-Seq_HELA_Human	1.12123924
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10841288
68	NCOR_22424771_ChIP-Seq_293T_Human	1.10192515
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10055382
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10023295
71	* MYB_26560356_Chip-Seq_TH1_Human	1.08854445
72	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.08020802
73	GATA1_22025678_ChIP-Seq_K562_Human	1.07540525
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.06693627
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05867672
76	* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04277498
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.04169581
78	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.02942534
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02592986
80	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02351080
81	MYC_18940864_ChIP-ChIP_HL60_Human	1.02134885
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.01542799
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01372005
84	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00898215
85	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99432512
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99239230
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99024173
88	VDR_24787735_ChIP-Seq_THP-1_Human	0.98670443
89	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95827726
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95502995
91	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93361964
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93180361
93	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.93061378
94	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.92642078
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90439829
96	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90281673
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89893896
98	* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88968912
99	P300_27268052_Chip-Seq_Bcells_Human	0.88927553
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.87469609

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.16503838
2	MP0003195_calcinosis	2.92197198
3	MP0001835_abnormal_antigen_presentation	2.75799013
4	MP0005084_abnormal_gallbladder_morpholo	2.73602501
5	MP0010386_abnormal_urinary_bladder	2.50345367
6	MP0000372_irregular_coat_pigmentation	2.46846130
7	MP0005645_abnormal_hypothalamus_physiol	2.31086479
8	MP0005075_abnormal_melanosome_morpholog	2.11564774
9	MP0002396_abnormal_hematopoietic_system	2.05830540
10	MP0005646_abnormal_pituitary_gland	1.99592579
11	MP0001800_abnormal_humoral_immune	1.91433910
12	MP0002928_abnormal_bile_duct	1.87924266
13	MP0005397_hematopoietic_system_phenotyp	1.87490372
14	MP0001545_abnormal_hematopoietic_system	1.87490372
15	MP0005464_abnormal_platelet_physiology	1.86860396
16	MP0009278_abnormal_bone_marrow	1.85445213
17	MP0003252_abnormal_bile_duct	1.84307570
18	MP0008058_abnormal_DNA_repair	1.78556398
19	MP0003183_abnormal_peptide_metabolism	1.76267987
20	MP0002876_abnormal_thyroid_physiology	1.75128343
21	MP0002148_abnormal_hypersensitivity_rea	1.71421102
22	MP0008872_abnormal_physiological_respon	1.70906650
23	MP0003806_abnormal_nucleotide_metabolis	1.57523538
24	MP0001986_abnormal_taste_sensitivity	1.57324192
25	MP0008877_abnormal_DNA_methylation	1.56754087
26	MP0002452_abnormal_antigen_presenting	1.55578422
27	MP0009785_altered_susceptibility_to	1.53169734
28	MP0000685_abnormal_immune_system	1.51572249
29	MP0001764_abnormal_homeostasis	1.50970071
30	MP0002723_abnormal_immune_serum	1.50461284
31	MP0005387_immune_system_phenotype	1.48453258
32	MP0001790_abnormal_immune_system	1.48453258
33	MP0002420_abnormal_adaptive_immunity	1.48269106
34	MP0002160_abnormal_reproductive_system	1.48079141
35	MP0001819_abnormal_immune_cell	1.47671771
36	MP0003718_maternal_effect	1.42686945
37	MP0004147_increased_porphyrin_level	1.42514432
38	MP0004808_abnormal_hematopoietic_stem	1.41232103
39	MP0003724_increased_susceptibility_to	1.41056048
40	MP0003763_abnormal_thymus_physiology	1.40069821
41	MP0001501_abnormal_sleep_pattern	1.38741522
42	MP0005671_abnormal_response_to	1.36537215
43	MP0005551_abnormal_eye_electrophysiolog	1.34221572
44	MP0000465_gastrointestinal_hemorrhage	1.33657793
45	MP0000681_abnormal_thyroid_gland	1.33637431
46	MP0002398_abnormal_bone_marrow	1.33317778
47	MP0005025_abnormal_response_to	1.33306576
48	MP0008995_early_reproductive_senescence	1.31999681
49	MP0008875_abnormal_xenobiotic_pharmacok	1.31449145
50	MP0005220_abnormal_exocrine_pancreas	1.31404352
51	MP0001873_stomach_inflammation	1.30456609
52	MP0002139_abnormal_hepatobiliary_system	1.30166486
53	MP0000716_abnormal_immune_system	1.29635533
54	MP0000689_abnormal_spleen_morphology	1.27715940
55	MP0005000_abnormal_immune_tolerance	1.27262489
56	MP0005389_reproductive_system_phenotype	1.24845091
57	MP0005410_abnormal_fertilization	1.19379003
58	MP0006082_CNS_inflammation	1.18911251
59	MP0002419_abnormal_innate_immunity	1.16717768
60	MP0005174_abnormal_tail_pigmentation	1.15747112
61	MP0005332_abnormal_amino_acid	1.14285770
62	MP0003787_abnormal_imprinting	1.13174272
63	MP0003638_abnormal_response/metabolism_	1.12831203
64	MP0006036_abnormal_mitochondrial_physio	1.11167288
65	MP0006292_abnormal_olfactory_placode	1.10628569
66	MP0002429_abnormal_blood_cell	1.06718610
67	MP0004043_abnormal_pH_regulation	1.06133567
68	MP0001968_abnormal_touch/_nociception	1.03903584
69	MP0002735_abnormal_chemical_nociception	1.02454944
70	MP0002722_abnormal_immune_system	1.01298430
71	MP0008057_abnormal_DNA_replication	1.01022835
72	MP0009643_abnormal_urine_homeostasis	1.00333655
73	MP0002405_respiratory_system_inflammati	1.00117962
74	MP0003943_abnormal_hepatobiliary_system	0.99548545
75	MP0006276_abnormal_autonomic_nervous	0.98716421
76	MP0000015_abnormal_ear_pigmentation	0.98389420
77	MP0005360_urolithiasis	0.97564063
78	MP0005085_abnormal_gallbladder_physiolo	0.97204813
79	MP0001905_abnormal_dopamine_level	0.94748933
80	MP0009764_decreased_sensitivity_to	0.94337512
81	MP0002102_abnormal_ear_morphology	0.92988357
82	MP0003646_muscle_fatigue	0.91836728
83	MP0001845_abnormal_inflammatory_respons	0.90056609
84	MP0009333_abnormal_splenocyte_physiolog	0.88457520
85	MP0002132_abnormal_respiratory_system	0.85455757
86	MP0009765_abnormal_xenobiotic_induced	0.84750988
87	MP0008469_abnormal_protein_level	0.83871178
88	MP0001929_abnormal_gametogenesis	0.81299645
89	MP0004019_abnormal_vitamin_homeostasis	0.80547767
90	MP0001664_abnormal_digestion	0.80500003
91	MP0002163_abnormal_gland_morphology	0.80434122
92	MP0003436_decreased_susceptibility_to	0.78457619
93	MP0000230_abnormal_systemic_arterial	0.78373386
94	MP0010329_abnormal_lipoprotein_level	0.78156892
95	MP0001919_abnormal_reproductive_system	0.77839913
96	MP0010155_abnormal_intestine_physiology	0.77272511
97	MP0003866_abnormal_defecation	0.76257763
98	MP0002136_abnormal_kidney_physiology	0.75854174
99	MP0001881_abnormal_mammary_gland	0.75089992
100	MP0002693_abnormal_pancreas_physiology	0.73001442

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	4.36821829
2	Hypothermia (HP:0002045)	3.85964006
3	Panhypogammaglobulinemia (HP:0003139)	3.76412620
4	Abnormality of B cell number (HP:0010975)	3.68547151
5	Thyroid-stimulating hormone excess (HP:0002925)	3.61681666
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.33390768
7	Pancreatic cysts (HP:0001737)	3.29198800
8	Abnormal drinking behavior (HP:0030082)	3.15544912
9	Polydipsia (HP:0001959)	3.15544912
10	Congenital stationary night blindness (HP:0007642)	3.12792573
11	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.12482950
12	B lymphocytopenia (HP:0010976)	3.10955316
13	Stomach cancer (HP:0012126)	3.10062103
14	Attenuation of retinal blood vessels (HP:0007843)	3.06437090
15	Acute lymphatic leukemia (HP:0006721)	3.04781713
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.00552370
17	Tetany (HP:0001281)	2.99321329
18	Decreased central vision (HP:0007663)	2.96369539
19	Abnormality of the prostate (HP:0008775)	2.95730686
20	Hypomagnesemia (HP:0002917)	2.93050859
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86965471
22	Autoimmune hemolytic anemia (HP:0001890)	2.75677369
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74030392
24	Molar tooth sign on MRI (HP:0002419)	2.68966716
25	Abnormality of midbrain morphology (HP:0002418)	2.68966716
26	Abolished electroretinogram (ERG) (HP:0000550)	2.60922832
27	Abnormality of T cell physiology (HP:0011840)	2.60732717
28	Abnormality of the renal cortex (HP:0011035)	2.51011855
29	Recurrent fungal infections (HP:0002841)	2.48700710
30	Polyuria (HP:0000103)	2.44899442
31	Chronic otitis media (HP:0000389)	2.39875114
32	Abnormality of the renal medulla (HP:0100957)	2.38935322
33	Chronic mucocutaneous candidiasis (HP:0002728)	2.36483362
34	Recurrent cutaneous fungal infections (HP:0011370)	2.36483362
35	Pancreatic fibrosis (HP:0100732)	2.31546818
36	Abnormal biliary tract physiology (HP:0012439)	2.30150492
37	Bile duct proliferation (HP:0001408)	2.30150492
38	3-Methylglutaconic aciduria (HP:0003535)	2.29295300
39	Nephronophthisis (HP:0000090)	2.28372942
40	True hermaphroditism (HP:0010459)	2.27391193
41	Abnormality of macular pigmentation (HP:0008002)	2.24734955
42	Meningitis (HP:0001287)	2.23830803
43	Abnormal protein N-linked glycosylation (HP:0012347)	2.22981169
44	Abnormal protein glycosylation (HP:0012346)	2.22981169
45	Abnormal glycosylation (HP:0012345)	2.22981169
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.22981169
47	Mitochondrial inheritance (HP:0001427)	2.21535772
48	Type I transferrin isoform profile (HP:0003642)	2.18468782
49	Abnormality of male internal genitalia (HP:0000022)	2.16514577
50	Increased CSF lactate (HP:0002490)	2.13668295
51	Dicarboxylic aciduria (HP:0003215)	2.10700848
52	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.10700848
53	Ketosis (HP:0001946)	2.07766822
54	Albinism (HP:0001022)	2.07427769
55	Hepatocellular necrosis (HP:0001404)	2.05111091
56	Granulocytopenia (HP:0001913)	2.02722631
57	Methylmalonic aciduria (HP:0012120)	2.02399991
58	Severe combined immunodeficiency (HP:0004430)	2.00586554
59	Chronic hepatic failure (HP:0100626)	1.99484675
60	Abnormal urine output (HP:0012590)	1.99167200
61	Prostate neoplasm (HP:0100787)	1.98923890
62	Aplastic anemia (HP:0001915)	1.97407656
63	Eosinophilia (HP:0001880)	1.96194832
64	Abnormality of magnesium homeostasis (HP:0004921)	1.95649893
65	Constricted visual fields (HP:0001133)	1.94900950
66	Cystic liver disease (HP:0006706)	1.94626151
67	Thyroiditis (HP:0100646)	1.94199938
68	Type II lissencephaly (HP:0007260)	1.93734587
69	Recurrent viral infections (HP:0004429)	1.92182777
70	Abnormality of T cells (HP:0002843)	1.90450579
71	Medial flaring of the eyebrow (HP:0010747)	1.89664177
72	Hepatic necrosis (HP:0002605)	1.86838304
73	Autoimmune thrombocytopenia (HP:0001973)	1.84347878
74	Chronic sinusitis (HP:0011109)	1.83604758
75	IgG deficiency (HP:0004315)	1.83221315
76	Neutropenia (HP:0001875)	1.81785693
77	Mediastinal lymphadenopathy (HP:0100721)	1.81550538
78	Tubulointerstitial nephritis (HP:0001970)	1.81237726
79	Cerebral palsy (HP:0100021)	1.79576262
80	Chronic diarrhea (HP:0002028)	1.78819055
81	Abnormality of renal excretion (HP:0011036)	1.78329946
82	Increased serum lactate (HP:0002151)	1.76773608
83	Thrombocytosis (HP:0001894)	1.76641670
84	Tubular atrophy (HP:0000092)	1.75348737
85	Lethargy (HP:0001254)	1.74223593
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73557872
87	Clumsiness (HP:0002312)	1.73263371
88	Abnormality of eosinophils (HP:0001879)	1.72414570
89	Stomatitis (HP:0010280)	1.72154990
90	Increased hepatocellular lipid droplets (HP:0006565)	1.70010281
91	Lipid accumulation in hepatocytes (HP:0006561)	1.69956821
92	Renal cortical cysts (HP:0000803)	1.69229314
93	Hyperglycinuria (HP:0003108)	1.66834337
94	Optic disc pallor (HP:0000543)	1.65938877
95	Recurrent bronchitis (HP:0002837)	1.65927893
96	Renal Fanconi syndrome (HP:0001994)	1.65347405
97	Macular degeneration (HP:0000608)	1.65146723
98	Acute necrotizing encephalopathy (HP:0006965)	1.65031033
99	Encephalitis (HP:0002383)	1.64457691
100	Increased intramyocellular lipid droplets (HP:0012240)	1.64455546

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.43885404
2	FRK	4.34040946
3	BCKDK	3.75207146
4	KIT	2.97399258
5	BMPR1B	2.91749086
6	MAP4K2	2.75988010
7	NUAK1	2.44650468
8	TEC	2.35933522
9	ADRBK2	2.30786832
10	FLT3	2.24792857
11	TLK1	2.03316535
12	PINK1	1.93688282
13	TXK	1.88139148
14	ACVR1B	1.84859354
15	GRK1	1.83661814
16	MAP4K1	1.81616633
17	EIF2AK3	1.71129257
18	VRK2	1.64087184
19	ZAK	1.60643815
20	CSF1R	1.58019759
21	BTK	1.54346440
22	SYK	1.47662525
23	IKBKB	1.37291567
24	INSRR	1.33800792
25	ITK	1.29926309
26	VRK1	1.29294902
27	MAPKAPK3	1.28914507
28	BMPR2	1.26636537
29	FES	1.25416650
30	IKBKE	1.22292979
31	PDK2	1.16162294
32	DAPK2	1.15322345
33	PRKCQ	1.12818359
34	PIK3CA	1.03578150
35	MATK	1.03527063
36	TNK2	1.03502232
37	TBK1	1.01510453
38	TGFBR1	0.98187159
39	ERN1	0.95319546
40	KDR	0.95020000
41	MKNK2	0.91744736
42	LYN	0.91000340
43	OXSR1	0.87790788
44	PIK3CG	0.87531655
45	TRIM28	0.85424979
46	MARK3	0.84542013
47	WNK3	0.81751481
48	MAPK13	0.81593952
49	ADRBK1	0.80807848
50	MST4	0.79299930
51	MKNK1	0.78495099
52	GRK6	0.76550753
53	MAPK15	0.73772578
54	CDK19	0.73423256
55	LCK	0.73252613
56	RPS6KA5	0.71158210
57	DAPK1	0.66929179
58	MAP3K14	0.65431020
59	TIE1	0.65309389
60	PKN1	0.64758628
61	HCK	0.64596965
62	NLK	0.63684708
63	MAP3K13	0.62098717
64	CSNK1G3	0.61807491
65	JAK3	0.60734523
66	CSNK1G1	0.60470311
67	NEK2	0.59378199
68	PRKCE	0.56083426
69	ATR	0.55936617
70	PIM1	0.55867878
71	ABL1	0.55839397
72	MAP3K7	0.50580468
73	STK16	0.49562807
74	RPS6KB2	0.49410539
75	TRPM7	0.48597131
76	IGF1R	0.48574369
77	MAP3K4	0.47507513
78	MAP2K7	0.44681293
79	CCNB1	0.42566359
80	IRAK1	0.41952129
81	RIPK4	0.41724595
82	MAP2K6	0.40470744
83	WNK4	0.40334435
84	CSNK1A1	0.40118632
85	MAPKAPK5	0.39440822
86	CHUK	0.38556665
87	CSNK1G2	0.38524354
88	ERBB3	0.38340864
89	FER	0.37265143
90	CDK3	0.37232302
91	RPS6KA6	0.36842065
92	EIF2AK2	0.34835004
93	PRKCA	0.34349605
94	PLK4	0.33508802
95	STK38L	0.33359955
96	CDK8	0.33124868
97	CSNK1A1L	0.32182458
98	MAPK3	0.32166133
99	RPS6KA4	0.30753532
100	CSNK2A1	0.30108657

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.97266446
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.58732161
3	Allograft rejection_Homo sapiens_hsa05330	2.78628896
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.69130027
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.64270828
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.53573031
7	Phototransduction_Homo sapiens_hsa04744	2.40985514
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.15064426
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12384089
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.10736997
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00856888
12	Homologous recombination_Homo sapiens_hsa03440	1.95479280
13	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.83579481
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76936798
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76828402
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.74577233
17	Butanoate metabolism_Homo sapiens_hsa00650	1.57147732
18	RNA polymerase_Homo sapiens_hsa03020	1.48770783
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.48426583
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48273971
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45684181
22	Base excision repair_Homo sapiens_hsa03410	1.45490607
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45335057
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.42734290
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38250291
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.37165558
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.30916561
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30713057
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29443162
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27667216
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27112852
32	Peroxisome_Homo sapiens_hsa04146	1.23178010
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.22741551
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.21244429
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20059129
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19585356
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19513225
38	African trypanosomiasis_Homo sapiens_hsa05143	1.17072586
39	Caffeine metabolism_Homo sapiens_hsa00232	1.15869887
40	Propanoate metabolism_Homo sapiens_hsa00640	1.13895934
41	Olfactory transduction_Homo sapiens_hsa04740	1.04385626
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03841618
43	Leishmaniasis_Homo sapiens_hsa05140	1.03690846
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.01337733
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.98271139
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98035232
47	Other glycan degradation_Homo sapiens_hsa00511	0.96902665
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95762668
49	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.95667963
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95592309
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.93511028
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91592027
53	Parkinsons disease_Homo sapiens_hsa05012	0.88429012
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.87395411
55	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83999830
56	Basal transcription factors_Homo sapiens_hsa03022	0.81662704
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80586578
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80439898
59	Retinol metabolism_Homo sapiens_hsa00830	0.79452525
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77636454
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.76866908
62	Ribosome_Homo sapiens_hsa03010	0.75148065
63	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.73959748
64	Protein export_Homo sapiens_hsa03060	0.73607441
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.73606897
66	Regulation of autophagy_Homo sapiens_hsa04140	0.71528863
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.71283930
68	Purine metabolism_Homo sapiens_hsa00230	0.70381939
69	RNA degradation_Homo sapiens_hsa03018	0.69774650
70	Herpes simplex infection_Homo sapiens_hsa05168	0.69343468
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.67089629
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66904303
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66793232
74	Salivary secretion_Homo sapiens_hsa04970	0.65764878
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63925155
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63115877
77	One carbon pool by folate_Homo sapiens_hsa00670	0.60505683
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60396496
79	Viral myocarditis_Homo sapiens_hsa05416	0.59428483
80	ABC transporters_Homo sapiens_hsa02010	0.58622790
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58431258
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57315203
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55941055
84	Metabolic pathways_Homo sapiens_hsa01100	0.54111960
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54037503
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53284078
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51955805
88	Glutathione metabolism_Homo sapiens_hsa00480	0.51591010
89	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.48695440
90	Proteasome_Homo sapiens_hsa03050	0.48656228
91	Platelet activation_Homo sapiens_hsa04611	0.47125032
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.46931441
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46644258
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44834286
95	Huntingtons disease_Homo sapiens_hsa05016	0.43214452
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42685672
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.39910803
98	Tuberculosis_Homo sapiens_hsa05152	0.38648733
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38068599
100	Histidine metabolism_Homo sapiens_hsa00340	0.37351818

C1ORF186

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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