ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	8.87520455
2	regulation of cilium movement (GO:0003352)	8.62356621
3	primary alcohol catabolic process (GO:0034310)	7.10883084
4	left/right axis specification (GO:0070986)	6.77119939
5	ventricular system development (GO:0021591)	6.74754659
6	vitamin transmembrane transport (GO:0035461)	6.60674318
7	microtubule bundle formation (GO:0001578)	6.58070569
8	intraciliary transport (GO:0042073)	6.45480880
9	ethanol metabolic process (GO:0006067)	6.15525888
10	diterpenoid biosynthetic process (GO:0016102)	6.05041678
11	cilium organization (GO:0044782)	6.01539802
12	centriole assembly (GO:0098534)	5.91073185
13	cilium assembly (GO:0042384)	5.87704713
14	one-carbon compound transport (GO:0019755)	5.47465977
15	sperm capacitation (GO:0048240)	5.43657137
16	pyrimidine-containing compound transmembrane transport (GO:0072531)	5.38195398
17	regulation of microtubule-based movement (GO:0060632)	5.18101050
18	tolerance induction (GO:0002507)	5.16155317
19	response to xenobiotic stimulus (GO:0009410)	5.15845073
20	microtubule depolymerization (GO:0007019)	5.13337764
21	glomerular epithelial cell development (GO:0072310)	4.97954929
22	lung epithelium development (GO:0060428)	4.94665530
23	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.84756759
24	negative regulation of B cell mediated immunity (GO:0002713)	4.72218515
25	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.72218515
26	protein localization to cilium (GO:0061512)	4.70747003
27	microtubule-based movement (GO:0007018)	4.69328656
28	negative regulation of T cell differentiation in thymus (GO:0033085)	4.65808934
29	establishment of apical/basal cell polarity (GO:0035089)	4.64733206
30	cellular component assembly involved in morphogenesis (GO:0010927)	4.62604587
31	ethanol oxidation (GO:0006069)	4.59413601
32	microtubule polymerization or depolymerization (GO:0031109)	4.58701377
33	regulation of interleukin-5 production (GO:0032674)	4.56824924
34	regulation of germinal center formation (GO:0002634)	4.31893020
35	negative regulation of humoral immune response (GO:0002921)	4.31543273
36	regulation of interleukin-13 production (GO:0032656)	4.29155328
37	cell projection assembly (GO:0030031)	4.25867549
38	positive regulation of tolerance induction (GO:0002645)	4.22842149
39	cilium morphogenesis (GO:0060271)	4.17637510
40	terpenoid biosynthetic process (GO:0016114)	4.14236594
41	establishment or maintenance of monopolar cell polarity (GO:0061339)	4.12799116
42	establishment of monopolar cell polarity (GO:0061162)	4.12799116
43	negative regulation of inclusion body assembly (GO:0090084)	3.97169795
44	sperm motility (GO:0030317)	3.96657904
45	retinoic acid metabolic process (GO:0042573)	3.95824555
46	cytoplasmic microtubule organization (GO:0031122)	3.90484489
47	nucleoside diphosphate phosphorylation (GO:0006165)	3.83708375
48	exogenous drug catabolic process (GO:0042738)	3.72675274
49	centriole replication (GO:0007099)	3.64020689
50	establishment of tissue polarity (GO:0007164)	3.32893722
51	establishment of planar polarity (GO:0001736)	3.32893722
52	primary alcohol metabolic process (GO:0034308)	3.21902717
53	regulation of tolerance induction (GO:0002643)	3.18148473
54	lateral ventricle development (GO:0021670)	3.15850976
55	retinol metabolic process (GO:0042572)	3.06269662
56	axonemal dynein complex assembly (GO:0070286)	22.6711818
57	O-glycan processing (GO:0016266)	2.98782510
58	regulation of microtubule depolymerization (GO:0031114)	2.96128254
59	glutathione derivative metabolic process (GO:1901685)	2.95844782
60	glutathione derivative biosynthetic process (GO:1901687)	2.95844782
61	positive regulation of smoothened signaling pathway (GO:0045880)	2.94127273
62	drug catabolic process (GO:0042737)	2.91573331
63	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.91163613
64	hydrogen peroxide biosynthetic process (GO:0050665)	2.90647047
65	aldehyde catabolic process (GO:0046185)	2.89966144
66	multicellular organismal water homeostasis (GO:0050891)	2.88472470
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.87958651
68	determination of left/right symmetry (GO:0007368)	2.87543991
69	microtubule-based process (GO:0007017)	2.81704472
70	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.80404840
71	determination of bilateral symmetry (GO:0009855)	2.76272398
72	phosphatidylcholine biosynthetic process (GO:0006656)	2.75137041
73	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.74841340
74	reactive oxygen species biosynthetic process (GO:1903409)	2.71930062
75	excretion (GO:0007588)	2.70474425
76	specification of symmetry (GO:0009799)	2.70170401
77	hydrogen peroxide catabolic process (GO:0042744)	2.64542353
78	organelle assembly (GO:0070925)	2.64332829
79	smoothened signaling pathway (GO:0007224)	2.63351282
80	carnitine metabolic process (GO:0009437)	2.61980696
81	oligosaccharide biosynthetic process (GO:0009312)	2.60969168
82	phosphatidylethanolamine metabolic process (GO:0046337)	2.56622968
83	base-excision repair, AP site formation (GO:0006285)	2.56272280
84	regulation of autophagic vacuole assembly (GO:2000785)	2.54559015
85	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.53398969
86	regulation of response to osmotic stress (GO:0047484)	2.53309483
87	lateral sprouting from an epithelium (GO:0060601)	2.51826851
88	progesterone metabolic process (GO:0042448)	2.50676238
89	protein polyglutamylation (GO:0018095)	2.50202635
90	pyrimidine nucleotide catabolic process (GO:0006244)	2.47214931
91	polyol transport (GO:0015791)	2.47189597
92	regulation of inclusion body assembly (GO:0090083)	2.46616835
93	water homeostasis (GO:0030104)	2.45057902
94	heart looping (GO:0001947)	2.44934838
95	cilium or flagellum-dependent cell motility (GO:0001539)	17.9699743
96	cilium movement (GO:0003341)	15.6966568
97	motile cilium assembly (GO:0044458)	15.0046900
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.9259593
99	epithelial cilium movement (GO:0003351)	13.9143300
100	axoneme assembly (GO:0035082)	10.4491087

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.45434029
2	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.36092270
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.35322925
4	DROSHA_22980978_ChIP-Seq_HELA_Human	3.31080839
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.14673893
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.35751724
7	SMC4_20622854_ChIP-Seq_HELA_Human	2.14100225
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.08357034
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.06644492
10	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.93216826
11	STAT1_20625510_ChIP-Seq_HELA_Human	1.89693922
12	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.78950584
13	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.78731259
14	AHR_22903824_ChIP-Seq_MCF-7_Human	1.73457460
15	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.67376121
16	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.66959818
17	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.65327942
18	KLF5_25053715_ChIP-Seq_YYC3_Human	1.65036100
19	* ELF1_20517297_ChIP-Seq_JURKAT_Human	1.64786186
20	TP63_22573176_ChIP-Seq_HFKS_Human	1.64685161
21	TP63_23658742_ChIP-Seq_EP156T_Human	1.64387167
22	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.63402626
23	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.61740698
24	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.58158999
25	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.56542566
26	ETV1_20927104_ChIP-Seq_GIST48_Human	1.54241298
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54133285
28	VDR_22108803_ChIP-Seq_LS180_Human	1.53249734
29	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.51074963
30	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.49854269
31	P68_20966046_ChIP-Seq_HELA_Human	1.49473625
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.48455713
33	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.46531928
34	* ESR1_20079471_ChIP-ChIP_T-47D_Human	1.45781885
35	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.45730693
36	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.42458493
37	PHF8_20622853_ChIP-Seq_HELA_Human	1.40503672
38	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.39647840
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38374895
40	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38056121
41	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.37896404
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37237452
43	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.35262198
44	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.33665302
45	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.33033413
46	TP53_18474530_ChIP-ChIP_U2OS_Human	1.32970157
47	* YY1_22570637_ChIP-Seq_MALME-3M_Human	1.32137859
48	PHF8_20622854_ChIP-Seq_HELA_Human	1.31148433
49	RBPJ_21746931_ChIP-Seq_IB4_Human	1.29350645
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.29214267
51	GATA1_19941826_ChIP-Seq_K562_Human	1.28008801
52	* CTCF_27219007_Chip-Seq_Bcells_Human	1.27748248
53	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25004576
54	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24673118
55	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.24207878
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.22714011
57	SOX2_20726797_ChIP-Seq_SW620_Human	1.21184568
58	* SMRT_27268052_Chip-Seq_Bcells_Human	1.20518206
59	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.18229704
60	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.17250459
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15299401
62	CREB1_26743006_Chip-Seq_LNCaP_Human	1.15102697
63	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.14726430
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.14689583
65	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.13677800
66	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13613537
67	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13509434
68	E2F1_20622854_ChIP-Seq_HELA_Human	1.12817619
69	GATA4_25053715_ChIP-Seq_YYC3_Human	1.10963201
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10795565
71	* P300_27268052_Chip-Seq_Bcells_Human	1.10094109
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08812645
73	NFYA_21822215_ChIP-Seq_K562_Human	1.07353830
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.07045551
75	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.05244429
76	* CEBPB_22108803_ChIP-Seq_LS180_Human	1.05240453
77	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.05070573
78	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04786669
79	NFYB_21822215_ChIP-Seq_K562_Human	1.04400308
80	SOX2_21211035_ChIP-Seq_LN229_Human	1.03814433
81	RACK7_27058665_Chip-Seq_MCF-7_Human	1.02218814
82	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97995248
83	LXR_22292898_ChIP-Seq_THP-1_Human	0.97653928
84	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.97386194
85	TBL1_22424771_ChIP-Seq_293T_Human	0.97248346
86	* BCOR_27268052_Chip-Seq_Bcells_Human	0.96551696
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95659841
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95570293
89	* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.94614127
90	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.94425739
91	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.94362743
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92850644
93	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92539465
94	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.92331427
95	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.92310508
96	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.92256357
97	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.90945283
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89318232
99	GATA2_19941826_ChIP-Seq_K562_Human	0.89073188
100	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.88562696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	6.99802112
2	MP0002653_abnormal_ependyma_morphology	6.38336670
3	MP0002132_abnormal_respiratory_system	5.87702518
4	MP0004043_abnormal_pH_regulation	4.18569266
5	MP0001984_abnormal_olfaction	4.00704800
6	MP0002277_abnormal_respiratory_mucosa	3.78816862
7	MP0009780_abnormal_chondrocyte_physiolo	3.51546663
8	MP0008789_abnormal_olfactory_epithelium	3.51496078
9	MP0004133_heterotaxia	3.43239352
10	MP0005623_abnormal_meninges_morphology	3.25355323
11	MP0000566_synostosis	2.89268167
12	MP0005377_hearing/vestibular/ear_phenot	2.55795275
13	MP0003878_abnormal_ear_physiology	2.55795275
14	MP0000383_abnormal_hair_follicle	2.31717825
15	MP0005394_taste/olfaction_phenotype	2.29740175
16	MP0005499_abnormal_olfactory_system	2.29740175
17	MP0003656_abnormal_erythrocyte_physiolo	2.06423942
18	MP0010678_abnormal_skin_adnexa	2.04338304
19	MP0002282_abnormal_trachea_morphology	2.04000524
20	MP0001765_abnormal_ion_homeostasis	1.97224938
21	MP0002168_other_aberrant_phenotype	1.89033699
22	MP0002160_abnormal_reproductive_system	1.88594153
23	MP0004019_abnormal_vitamin_homeostasis	1.86420164
24	MP0005083_abnormal_biliary_tract	1.85812978
25	MP0000678_abnormal_parathyroid_gland	1.72314844
26	MP0009379_abnormal_foot_pigmentation	1.60005746
27	MP0001346_abnormal_lacrimal_gland	1.47874375
28	MP0010234_abnormal_vibrissa_follicle	1.37865638
29	MP0005636_abnormal_mineral_homeostasis	1.33105664
30	MP0002249_abnormal_larynx_morphology	1.32666930
31	MP0002909_abnormal_adrenal_gland	1.32313150
32	MP0005248_abnormal_Harderian_gland	1.30985402
33	MP0005395_other_phenotype	1.28621028
34	MP0005310_abnormal_salivary_gland	1.27081267
35	MP0010155_abnormal_intestine_physiology	1.26217890
36	MP0001929_abnormal_gametogenesis	1.25575283
37	MP0003698_abnormal_male_reproductive	1.21292171
38	MP0005165_increased_susceptibility_to	1.20593252
39	MP0000465_gastrointestinal_hemorrhage	1.14754316
40	MP0005408_hypopigmentation	1.09895753
41	MP0002734_abnormal_mechanical_nocicepti	1.09004105
42	MP0010030_abnormal_orbit_morphology	1.08588171
43	MP0000681_abnormal_thyroid_gland	1.01010442
44	MP0002876_abnormal_thyroid_physiology	1.00625862
45	MP0003303_peritoneal_inflammation	0.97310831
46	MP0002735_abnormal_chemical_nociception	0.96502501
47	MP0002233_abnormal_nose_morphology	0.94974715
48	MP0009643_abnormal_urine_homeostasis	0.94944387
49	MP0005389_reproductive_system_phenotype	0.93544271
50	MP0001485_abnormal_pinna_reflex	0.92898457
51	MP0004264_abnormal_extraembryonic_tissu	0.91623812
52	MP0005164_abnormal_response_to	0.91495756
53	MP0002638_abnormal_pupillary_reflex	0.87602802
54	MP0005409_darkened_coat_color	0.86409710
55	MP0005365_abnormal_bile_salt	0.85808423
56	MP0002136_abnormal_kidney_physiology	0.85732325
57	MP0005410_abnormal_fertilization	0.76377342
58	MP0003453_abnormal_keratinocyte_physiol	0.74865856
59	MP0009765_abnormal_xenobiotic_induced	0.74284943
60	MP0002098_abnormal_vibrissa_morphology	0.73525599
61	MP0002139_abnormal_hepatobiliary_system	0.72675243
62	MP0004883_abnormal_blood_vessel	0.72110520
63	MP0001849_ear_inflammation	0.70495519
64	MP0003890_abnormal_embryonic-extraembry	0.69748804
65	MP0001270_distended_abdomen	0.69304834
66	MP0002405_respiratory_system_inflammati	0.66345542
67	MP0008995_early_reproductive_senescence	0.64584002
68	MP0005085_abnormal_gallbladder_physiolo	0.64277255
69	MP0005253_abnormal_eye_physiology	0.60945331
70	MP0002161_abnormal_fertility/fecundity	0.60336845
71	MP0006036_abnormal_mitochondrial_physio	0.59141381
72	MP0004782_abnormal_surfactant_physiolog	0.57917937
73	MP0009763_increased_sensitivity_to	0.56926724
74	MP0000858_altered_metastatic_potential	0.56370082
75	MP0000467_abnormal_esophagus_morphology	0.55809004
76	MP0003075_altered_response_to	0.55025162
77	MP0003191_abnormal_cellular_cholesterol	0.54158868
78	MP0002928_abnormal_bile_duct	0.53197252
79	MP0001790_abnormal_immune_system	0.53107057
80	MP0005387_immune_system_phenotype	0.53107057
81	MP0000026_abnormal_inner_ear	0.52694057
82	MP0005220_abnormal_exocrine_pancreas	0.51926914
83	MP0006082_CNS_inflammation	0.51069363
84	MP0001663_abnormal_digestive_system	0.48343994
85	MP0003136_yellow_coat_color	0.47275668
86	MP0005551_abnormal_eye_electrophysiolog	0.46846875
87	MP0009703_decreased_birth_body	0.46468802
88	MP0002822_catalepsy	0.46461919
89	MP0001293_anophthalmia	0.45626828
90	MP0001324_abnormal_eye_pigmentation	0.44174600
91	MP0001727_abnormal_embryo_implantation	0.43969530
92	MP0003866_abnormal_defecation	0.42705550
93	MP0001299_abnormal_eye_distance/	0.42399467
94	MP0001502_abnormal_circadian_rhythm	0.42247877
95	MP0002135_abnormal_kidney_morphology	0.41838868
96	MP0001666_abnormal_nutrient_absorption	0.41763819
97	MP0001664_abnormal_digestion	0.41393317
98	MP0002084_abnormal_developmental_patter	0.41037936
99	MP0005388_respiratory_system_phenotype	0.40123526
100	MP0002133_abnormal_respiratory_system	0.40123526

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	8.10137415
2	Bronchiectasis (HP:0002110)	7.62689406
3	Nasal polyposis (HP:0100582)	6.97744992
4	Abnormality of the nasal mucosa (HP:0000433)	5.79300708
5	Infertility (HP:0000789)	4.60578574
6	Recurrent sinusitis (HP:0011108)	4.36989427
7	Bronchitis (HP:0012387)	4.34878492
8	Chronic sinusitis (HP:0011109)	4.27793549
9	Male infertility (HP:0003251)	4.08689318
10	Recurrent otitis media (HP:0000403)	3.92467331
11	Occipital encephalocele (HP:0002085)	3.48760516
12	Pancreatic fibrosis (HP:0100732)	3.31965751
13	Atelectasis (HP:0100750)	3.29986708
14	True hermaphroditism (HP:0010459)	3.24319456
15	Chronic otitis media (HP:0000389)	3.13428351
16	Hyperactive renin-angiotensin system (HP:0000841)	2.99398582
17	Cystic liver disease (HP:0006706)	2.71370903
18	Molar tooth sign on MRI (HP:0002419)	2.70346728
19	Abnormality of midbrain morphology (HP:0002418)	2.70346728
20	Nephronophthisis (HP:0000090)	2.63571933
21	Pancreatic cysts (HP:0001737)	2.62679624
22	Chronic hepatic failure (HP:0100626)	2.51590325
23	Postaxial foot polydactyly (HP:0001830)	2.30259941
24	Tubulointerstitial nephritis (HP:0001970)	2.25082821
25	Bell-shaped thorax (HP:0001591)	2.10231713
26	Abnormality of the renal medulla (HP:0100957)	2.03390621
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5699052
28	Abnormal respiratory epithelium morphology (HP:0012253)	11.5390477
29	Abnormal respiratory motile cilium morphology (HP:0005938)	11.5390477
30	Abnormal respiratory motile cilium physiology (HP:0012261)	11.1268662
31	Absent/shortened dynein arms (HP:0200106)	10.8304599
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.8304599
33	Abnormal ciliary motility (HP:0012262)	10.7577881
34	Rhinitis (HP:0012384)	10.2936921
35	Congenital hepatic fibrosis (HP:0002612)	1.93239505
36	Anencephaly (HP:0002323)	1.92616090
37	Decreased circulating renin level (HP:0003351)	1.84486954
38	Medial flaring of the eyebrow (HP:0010747)	1.83637082
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83283204
40	Renal salt wasting (HP:0000127)	1.82266887
41	Absent frontal sinuses (HP:0002688)	1.81859454
42	Male pseudohermaphroditism (HP:0000037)	1.79263608
43	Recurrent bronchitis (HP:0002837)	1.76887983
44	Hyperkalemia (HP:0002153)	1.75156640
45	Congenital primary aphakia (HP:0007707)	1.74389968
46	Asplenia (HP:0001746)	1.74286574
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72305724
48	Gait imbalance (HP:0002141)	1.70789855
49	Nephropathy (HP:0000112)	1.62189336
50	Oculomotor apraxia (HP:0000657)	1.57500779
51	Sclerocornea (HP:0000647)	1.53307603
52	Furrowed tongue (HP:0000221)	1.52092217
53	Tubular atrophy (HP:0000092)	1.51314839
54	Nephrogenic diabetes insipidus (HP:0009806)	1.49931124
55	Postaxial hand polydactyly (HP:0001162)	1.48514273
56	Hyperaldosteronism (HP:0000859)	1.47893301
57	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.38920236
58	Abnormality of chloride homeostasis (HP:0011422)	1.38261069
59	Abnormality of renin-angiotensin system (HP:0000847)	1.33152451
60	Median cleft lip (HP:0000161)	1.31536232
61	Cone-rod dystrophy (HP:0000548)	1.26725328
62	Preaxial hand polydactyly (HP:0001177)	1.25842691
63	Fetal akinesia sequence (HP:0001989)	1.25729007
64	Stage 5 chronic kidney disease (HP:0003774)	1.24186907
65	Hypokalemic alkalosis (HP:0001949)	1.23364324
66	Short thorax (HP:0010306)	1.22393134
67	Hyponatremia (HP:0002902)	1.21045092
68	Poor coordination (HP:0002370)	1.20890785
69	Hand muscle atrophy (HP:0009130)	1.19882378
70	Decreased central vision (HP:0007663)	1.18522222
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.17874393
72	Tubulointerstitial abnormality (HP:0001969)	1.17589073
73	Genital tract atresia (HP:0001827)	1.16990067
74	Vaginal atresia (HP:0000148)	1.16835907
75	Abnormality of the distal phalanges of the toes (HP:0010182)	1.15297381
76	Supernumerary spleens (HP:0009799)	1.14088952
77	Bifid scrotum (HP:0000048)	1.13885759
78	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.12984056
79	Glucose intolerance (HP:0000833)	1.12771629
80	Short nail (HP:0001799)	1.12360595
81	Abnormality of the dental root (HP:0006486)	1.12280134
82	Taurodontia (HP:0000679)	1.12280134
83	Abnormality of permanent molar morphology (HP:0011071)	1.12280134
84	Abnormality of the frontal sinuses (HP:0002687)	1.09009052
85	Popliteal pterygium (HP:0009756)	1.08535086
86	Lip pit (HP:0100267)	1.04690029
87	Abnormality of macular pigmentation (HP:0008002)	1.04334126
88	Abnormality of molar morphology (HP:0011070)	1.02034812
89	Abnormality of molar (HP:0011077)	1.02034812
90	Polydipsia (HP:0001959)	1.01565735
91	Abnormal drinking behavior (HP:0030082)	1.01565735
92	Abnormality of the dental pulp (HP:0006479)	1.01150811
93	Abnormality of monocarboxylic acid metabolism (HP:0010996)	0.97058985
94	Flat acetabular roof (HP:0003180)	0.96617474
95	Short femoral neck (HP:0100864)	0.96517468
96	Absent speech (HP:0001344)	0.96062608
97	Aplasia of the musculature (HP:0100854)	0.93758645
98	Obstructive sleep apnea (HP:0002870)	0.93710771
99	Retinitis pigmentosa (HP:0000510)	0.92156458
100	Muscle fiber splitting (HP:0003555)	0.91310379

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.47416303
2	EPHA2	4.81225406
3	NME1	2.14924390
4	MAP3K2	2.08285940
5	SMG1	2.07681357
6	MAPK15	11.8027526
7	MAPKAPK3	1.99699354
8	PNCK	1.98235063
9	STK24	1.91778857
10	PTK2B	1.82726856
11	TTK	1.71209168
12	MAP3K3	1.52274000
13	NEK6	1.49899818
14	CSK	1.48469311
15	EEF2K	1.47144579
16	TESK1	1.31174205
17	PLK4	1.28554445
18	MST1R	1.25658597
19	LRRK2	1.24002454
20	BCR	1.22036768
21	BRSK2	1.08373312
22	EPHB1	1.08241499
23	MARK2	1.02002046
24	STK10	1.01112045
25	STK38	0.98158821
26	MAP3K12	0.98128737
27	TLK1	0.96836211
28	RIPK4	0.89910389
29	CAMKK1	0.88960427
30	TBK1	0.86492204
31	PRKCI	0.85455561
32	MAP3K7	0.85390962
33	INSRR	0.80551279
34	TRPM7	0.71733720
35	ERBB3	0.71042257
36	BRD4	0.69811757
37	CAMKK2	0.67042754
38	CDK12	0.64029979
39	STK16	0.63938499
40	ERBB2	0.57958958
41	ICK	0.57419922
42	GRK6	0.55140110
43	PDPK1	0.53595312
44	TRIB3	0.53566255
45	MET	0.52309649
46	PRKAA2	0.50581997
47	AURKA	0.49443347
48	SGK1	0.46644394
49	DYRK1B	0.46326563
50	PRKD3	0.45030223
51	EPHA3	0.44932080
52	PRKCD	0.42143390
53	CAMK2G	0.41268698
54	PRKCQ	0.41027975
55	IRAK1	0.39800819
56	CDK6	0.39066794
57	RIPK1	0.38541283
58	MAP3K11	0.36674701
59	PLK1	0.33595008
60	MAP3K4	0.32113067
61	TAOK1	0.32065729
62	MAP2K2	0.31482225
63	EPHA4	0.30017544
64	NLK	0.29891474
65	HIPK2	0.29649439
66	CAMK1G	0.28935741
67	STK38L	0.28643232
68	MAP2K4	0.27033848
69	PDK1	0.25869731
70	PAK4	0.23851410
71	ACVR1B	0.23532708
72	PAK1	0.23339271
73	OXSR1	0.23310326
74	RPS6KB2	0.23147571
75	PBK	0.22504736
76	FER	0.22294016
77	ROCK1	0.21267711
78	CHEK2	0.20696012
79	PRKACA	0.20133900
80	DYRK1A	0.18985355
81	RET	0.18551073
82	CDC42BPA	0.18404191
83	LMTK2	0.17438484
84	TYK2	0.17170154
85	NEK9	0.16708342
86	FYN	0.16232849
87	PRKCA	0.15166709
88	PRKCZ	0.14670716
89	ARAF	0.14545707
90	ADRBK1	0.14423125
91	ABL1	0.14407992
92	PTK6	0.13876467
93	ZAP70	0.13262217
94	PLK2	0.12812811
95	MAP2K7	0.11557050
96	FGFR3	0.11428467
97	SRC	0.11355184
98	ROCK2	0.10055172
99	KSR2	0.09764412
100	CAMK2A	0.09504088

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.85900775
2	Phenylalanine metabolism_Homo sapiens_hsa00360	5.11064247
3	Chemical carcinogenesis_Homo sapiens_hsa05204	4.64586439
4	Histidine metabolism_Homo sapiens_hsa00340	4.48941011
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.35043175
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.92478720
7	beta-Alanine metabolism_Homo sapiens_hsa00410	2.99557206
8	Huntingtons disease_Homo sapiens_hsa05016	2.72096400
9	Glutathione metabolism_Homo sapiens_hsa00480	2.68798314
10	Caffeine metabolism_Homo sapiens_hsa00232	2.62964110
11	Retinol metabolism_Homo sapiens_hsa00830	2.41224861
12	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.89630443
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85823446
14	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.84449169
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.83057132
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.74492813
17	Sphingolipid metabolism_Homo sapiens_hsa00600	1.62672448
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.61556485
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55391147
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.46768495
21	Fatty acid degradation_Homo sapiens_hsa00071	1.44046236
22	Tight junction_Homo sapiens_hsa04530	1.30168924
23	ABC transporters_Homo sapiens_hsa02010	1.28722663
24	Peroxisome_Homo sapiens_hsa04146	1.18901737
25	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.11783857
26	Salivary secretion_Homo sapiens_hsa04970	1.11351016
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99478928
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.93864911
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.92782744
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88473346
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.88426122
32	Circadian rhythm_Homo sapiens_hsa04710	0.82096864
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81583964
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78575973
35	Choline metabolism in cancer_Homo sapiens_hsa05231	0.76715238
36	Notch signaling pathway_Homo sapiens_hsa04330	0.75210159
37	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73844012
38	Hepatitis C_Homo sapiens_hsa05160	0.70262143
39	Olfactory transduction_Homo sapiens_hsa04740	0.69675736
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66532345
41	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.65346957
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63778210
43	Taste transduction_Homo sapiens_hsa04742	0.63144453
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57552607
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.56076662
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52247802
47	Adherens junction_Homo sapiens_hsa04520	0.50932333
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47633663
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47182853
50	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47168100
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39737946
52	Complement and coagulation cascades_Homo sapiens_hsa04610	0.39120084
53	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.33655488
54	Lysosome_Homo sapiens_hsa04142	0.32669339
55	Amoebiasis_Homo sapiens_hsa05146	0.31128871
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.29598014
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.29179303
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28804986
59	Metabolic pathways_Homo sapiens_hsa01100	0.28752757
60	Nicotine addiction_Homo sapiens_hsa05033	0.28039932
61	Phototransduction_Homo sapiens_hsa04744	0.27902945
62	Regulation of autophagy_Homo sapiens_hsa04140	0.27310998
63	Allograft rejection_Homo sapiens_hsa05330	0.26102702
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.24642638
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.24354184
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.24220236
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.23884866
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23694201
69	Cocaine addiction_Homo sapiens_hsa05030	0.23431206
70	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.19727525
71	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.19681435
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.19006418
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.17822313
74	Endocytosis_Homo sapiens_hsa04144	0.17820381
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.17810025
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.17476384
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17407598
78	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.16181442
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.15171280
80	Serotonergic synapse_Homo sapiens_hsa04726	0.14908080
81	Insulin resistance_Homo sapiens_hsa04931	0.14489911
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.14290321
83	Phagosome_Homo sapiens_hsa04145	0.14288418
84	Antigen processing and presentation_Homo sapiens_hsa04612	0.13358909
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.13152610
86	Pancreatic secretion_Homo sapiens_hsa04972	0.12970640
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.12593763
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.12275311
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.11402399
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.11104024
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.10758579
92	Asthma_Homo sapiens_hsa05310	0.10626790
93	Prostate cancer_Homo sapiens_hsa05215	0.09977167
94	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.09724458
95	Amphetamine addiction_Homo sapiens_hsa05031	0.09234664
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.07933261
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.07474175
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.06897372
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.06608226
100	Bile secretion_Homo sapiens_hsa04976	0.05032573

C1ORF189

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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