C1ORF198

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.79900346
2regulation of integrin-mediated signaling pathway (GO:2001044)4.58556084
3protein heterotrimerization (GO:0070208)4.23032536
4cell migration involved in heart development (GO:0060973)3.95034570
5extracellular fibril organization (GO:0043206)3.94639049
6chondrocyte proliferation (GO:0035988)3.82432513
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.78064612
8fibroblast migration (GO:0010761)3.64245811
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.63173933
10substrate adhesion-dependent cell spreading (GO:0034446)3.29826059
11negative regulation of chondrocyte differentiation (GO:0032331)3.27724609
12protein localization to cell surface (GO:0034394)3.22258288
13metanephric mesenchyme development (GO:0072075)3.22015841
14kidney mesenchyme development (GO:0072074)3.18081319
15negative regulation of axon extension involved in axon guidance (GO:0048843)3.13093394
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07602576
17mesenchymal-epithelial cell signaling (GO:0060638)3.02279468
18extracellular matrix assembly (GO:0085029)3.02241152
19fibril organization (GO:0097435)3.02084506
20negative regulation of protein localization to cell surface (GO:2000009)3.01639229
21neuron projection extension involved in neuron projection guidance (GO:1902284)2.96809650
22axon extension involved in axon guidance (GO:0048846)2.96809650
23endodermal cell differentiation (GO:0035987)2.94226977
24dermatan sulfate biosynthetic process (GO:0030208)2.87525505
25skin morphogenesis (GO:0043589)2.87005611
26hippo signaling (GO:0035329)2.84165205
27planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83199785
28paraxial mesoderm development (GO:0048339)2.82198961
29cardiac myofibril assembly (GO:0055003)2.80344562
30peripheral nervous system axon ensheathment (GO:0032292)2.80313960
31myelination in peripheral nervous system (GO:0022011)2.80313960
32bone trabecula formation (GO:0060346)2.79226966
33positive regulation of fibroblast migration (GO:0010763)2.77991006
34sequestering of extracellular ligand from receptor (GO:0035581)2.77580180
35regulation of cardioblast differentiation (GO:0051890)2.74877779
36endocardial cushion development (GO:0003197)2.73585445
37negative regulation of smooth muscle cell migration (GO:0014912)2.72338527
38negative regulation of axon guidance (GO:1902668)2.67553461
39type B pancreatic cell proliferation (GO:0044342)2.65899239
40negative chemotaxis (GO:0050919)2.64143321
41regulation of axon extension involved in axon guidance (GO:0048841)2.63505636
42dermatan sulfate metabolic process (GO:0030205)2.63185817
43membrane assembly (GO:0071709)2.62740051
44response to gravity (GO:0009629)2.62684770
45actin filament depolymerization (GO:0030042)2.62395574
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60133310
47notochord development (GO:0030903)2.57039990
48negative regulation of cartilage development (GO:0061037)2.55848802
49negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.54544603
50collagen metabolic process (GO:0032963)2.54077953
51endothelial cell morphogenesis (GO:0001886)2.53015197
52smooth muscle tissue development (GO:0048745)2.51696963
53embryonic cranial skeleton morphogenesis (GO:0048701)2.50470500
54anterior/posterior axis specification, embryo (GO:0008595)2.50114313
55glomerular basement membrane development (GO:0032836)2.48946520
56barbed-end actin filament capping (GO:0051016)2.48462524
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48297832
58muscle cell migration (GO:0014812)2.48119834
59chondrocyte development (GO:0002063)2.46918747
60cartilage condensation (GO:0001502)2.46426256
61cell aggregation (GO:0098743)2.46426256
62pericardium development (GO:0060039)2.46133667
63collagen catabolic process (GO:0030574)2.45788956
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44883339
65negative regulation of embryonic development (GO:0045992)2.44169995
66outer ear morphogenesis (GO:0042473)2.43400533
67keratan sulfate catabolic process (GO:0042340)2.43024497
68positive regulation of epithelial to mesenchymal transition (GO:0010718)2.40972716
69ventricular cardiac muscle cell development (GO:0055015)2.40552415
70regulation of axon guidance (GO:1902667)2.39872475
71endocrine hormone secretion (GO:0060986)2.39234903
72retina vasculature morphogenesis in camera-type eye (GO:0061299)2.38984152
73negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.37812408
74extracellular matrix organization (GO:0030198)2.36987467
75muscle cell cellular homeostasis (GO:0046716)2.36832291
76positive regulation of actin filament depolymerization (GO:0030836)2.36178962
77extracellular structure organization (GO:0043062)2.36092799
78multicellular organismal macromolecule metabolic process (GO:0044259)2.35786296
79regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.35367649
80regulation of organ formation (GO:0003156)2.34906193
81basement membrane organization (GO:0071711)2.34789810
82cell adhesion mediated by integrin (GO:0033627)2.33907077
83negative regulation of BMP signaling pathway (GO:0030514)2.33519266
84cochlea morphogenesis (GO:0090103)2.33101215
85regulation of chondrocyte differentiation (GO:0032330)2.32710808
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32259866
87organ induction (GO:0001759)2.31048657
88protein retention in ER lumen (GO:0006621)2.28332901
89negative regulation of nitric-oxide synthase activity (GO:0051001)2.27244126
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26135153
91stress fiber assembly (GO:0043149)2.26046446
92multicellular organismal metabolic process (GO:0044236)2.25676400
93convergent extension (GO:0060026)2.23129995
94cell-substrate adhesion (GO:0031589)2.21985662
95negative regulation of endothelial cell proliferation (GO:0001937)2.21845745
96positive regulation of osteoblast proliferation (GO:0033690)2.20874593
97regulation of cartilage development (GO:0061035)2.20568443
98regulation of establishment of planar polarity (GO:0090175)2.20434182
99vascular endothelial growth factor signaling pathway (GO:0038084)2.19642968
100multicellular organismal catabolic process (GO:0044243)2.19152180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.09777484
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.15168305
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.77505625
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66713527
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.50894949
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.44480649
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33309408
8CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.25958913
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25429223
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11529312
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08191601
12BRD4_25478319_ChIP-Seq_HGPS_Human2.03274358
13EED_16625203_ChIP-ChIP_MESCs_Mouse1.97430801
14CJUN_26792858_Chip-Seq_BT549_Human1.96632047
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93019057
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91690446
17GBX2_23144817_ChIP-Seq_PC3_Human1.91447359
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.91334968
19CLOCK_20551151_ChIP-Seq_293T_Human1.88568992
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85289951
21NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85289951
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80714297
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80714297
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80269521
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71603398
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69161874
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68293309
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67778899
29TP53_18474530_ChIP-ChIP_U2OS_Human1.67421637
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67158418
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66188517
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64213228
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59380576
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58623229
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56947604
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50827135
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47637117
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45083358
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.44907675
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43947540
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41853979
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41587162
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40659339
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39708074
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.38633858
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38328827
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36757437
48TP53_16413492_ChIP-PET_HCT116_Human1.34366932
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33527214
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.31059448
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30171529
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29405551
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27356451
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25557556
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.24788985
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.24154738
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23326491
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21096112
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.20591509
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20178477
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19727012
62SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.18768159
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16579331
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16276019
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13473959
66SMAD4_21799915_ChIP-Seq_A2780_Human1.13188047
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11940894
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10354357
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08957616
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05451666
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.05323646
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.05323646
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04564596
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04463453
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04421226
76TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04385776
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.02399148
78SA1_22415368_ChIP-Seq_MEFs_Mouse0.99681065
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98146760
80EZH2_27294783_Chip-Seq_ESCs_Mouse0.98036231
81TP53_20018659_ChIP-ChIP_R1E_Mouse0.98031099
82AHR_22903824_ChIP-Seq_MCF-7_Human0.97143413
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.96703069
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96056468
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95524602
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94371859
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.94351359
88* P300_19829295_ChIP-Seq_ESCs_Human0.93994217
89RING1B_27294783_Chip-Seq_NPCs_Mouse0.92907499
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.92635949
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.91295492
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90986114
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89733741
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88952991
95SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88764999
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88550260
97EZH2_22144423_ChIP-Seq_EOC_Human0.88073325
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88014637
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88002204
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.87828400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.28054785
2MP0005503_abnormal_tendon_morphology4.36657891
3MP0005275_abnormal_skin_tensile3.79523803
4MP0004272_abnormal_basement_membrane3.47423930
5MP0001958_emphysema3.22134995
6MP0003950_abnormal_plasma_membrane3.17593606
7MP0003705_abnormal_hypodermis_morpholog3.17231230
8MP0003279_aneurysm3.11044944
9MP0010030_abnormal_orbit_morphology2.63500650
10MP0009780_abnormal_chondrocyte_physiolo2.62961883
11MP0005257_abnormal_intraocular_pressure2.47914531
12MP0005171_absent_coat_pigmentation2.39822370
13MP0005623_abnormal_meninges_morphology2.25619833
14MP0001299_abnormal_eye_distance/2.09657557
15MP0006054_spinal_hemorrhage2.09265657
16MP0003566_abnormal_cell_adhesion2.08159750
17MP0000749_muscle_degeneration1.98901439
18MP0002295_abnormal_pulmonary_circulatio1.89899512
19MP0002108_abnormal_muscle_morphology1.89767304
20MP0001542_abnormal_bone_strength1.87735031
21MP0005508_abnormal_skeleton_morphology1.86910823
22MP0009384_cardiac_valve_regurgitation1.82351788
23MP0000751_myopathy1.70910166
24MP0010368_abnormal_lymphatic_system1.65771848
25MP0009250_abnormal_appendicular_skeleto1.59028429
26MP0003941_abnormal_skin_development1.53715402
27MP0004084_abnormal_cardiac_muscle1.50665268
28MP0000767_abnormal_smooth_muscle1.50040471
29MP0005023_abnormal_wound_healing1.48588361
30MP0000534_abnormal_ureter_morphology1.46146355
31MP0003942_abnormal_urinary_system1.30775724
32MP0002282_abnormal_trachea_morphology1.29773096
33MP0003283_abnormal_digestive_organ1.28851004
34MP0005595_abnormal_vascular_smooth1.26987627
35MP0003091_abnormal_cell_migration1.26093232
36MP0002938_white_spotting1.21370297
37MP0000762_abnormal_tongue_morphology1.21170685
38MP0003755_abnormal_palate_morphology1.18194620
39MP0002102_abnormal_ear_morphology1.14476506
40MP0003385_abnormal_body_wall1.08939087
41MP0002060_abnormal_skin_morphology1.07187912
42MP0001879_abnormal_lymphatic_vessel1.06594609
43MP0002896_abnormal_bone_mineralization1.06047513
44MP0005620_abnormal_muscle_contractility1.04315427
45MP0000049_abnormal_middle_ear0.99608512
46MP0006138_congestive_heart_failure0.98691599
47MP0003937_abnormal_limbs/digits/tail_de0.97791426
48MP0009053_abnormal_anal_canal0.96599013
49MP0010352_gastrointestinal_tract_polyps0.96002511
50MP0004036_abnormal_muscle_relaxation0.94206450
51MP0002233_abnormal_nose_morphology0.93270326
52MP0000428_abnormal_craniofacial_morphol0.92130976
53MP0010386_abnormal_urinary_bladder0.90076871
54MP0000759_abnormal_skeletal_muscle0.88834064
55MP0000163_abnormal_cartilage_morphology0.88056459
56MP0000432_abnormal_head_morphology0.87717584
57MP0003136_yellow_coat_color0.87042489
58MP0000462_abnormal_digestive_system0.87004844
59MP0001177_atelectasis0.85426217
60MP0000013_abnormal_adipose_tissue0.84541933
61MP0005670_abnormal_white_adipose0.83471135
62MP0000733_abnormal_muscle_development0.82367368
63MP0004270_analgesia0.82144599
64MP0002128_abnormal_blood_circulation0.82074022
65MP0002133_abnormal_respiratory_system0.81795548
66MP0005388_respiratory_system_phenotype0.81795548
67MP0003935_abnormal_craniofacial_develop0.81164119
68MP0001243_abnormal_dermal_layer0.81087515
69MP0002115_abnormal_skeleton_extremities0.80943884
70MP0002972_abnormal_cardiac_muscle0.80715105
71MP0002116_abnormal_craniofacial_bone0.79770703
72MP0004087_abnormal_muscle_fiber0.79317004
73MP0000372_irregular_coat_pigmentation0.77617000
74MP0008775_abnormal_heart_ventricle0.75565233
75MP0004859_abnormal_synaptic_plasticity0.75026760
76MP0005187_abnormal_penis_morphology0.74967260
77MP0000003_abnormal_adipose_tissue0.72730503
78MP0004858_abnormal_nervous_system0.72625585
79MP0005248_abnormal_Harderian_gland0.71732535
80MP0002114_abnormal_axial_skeleton0.70402402
81MP0004134_abnormal_chest_morphology0.69709524
82MP0005197_abnormal_uvea_morphology0.69644893
83MP0000778_abnormal_nervous_system0.69608500
84MP0000747_muscle_weakness0.69578433
85MP0004215_abnormal_myocardial_fiber0.66335067
86MP0005193_abnormal_anterior_eye0.64367077
87MP0005369_muscle_phenotype0.63653226
88MP0005367_renal/urinary_system_phenotyp0.63207159
89MP0000516_abnormal_urinary_system0.63207159
90MP0002697_abnormal_eye_size0.63073881
91MP0002932_abnormal_joint_morphology0.60605301
92MP0003137_abnormal_impulse_conducting0.60437997
93MP0003115_abnormal_respiratory_system0.60402969
94MP0001614_abnormal_blood_vessel0.60329124
95MP0001984_abnormal_olfaction0.58613227
96MP0005390_skeleton_phenotype0.58299412
97MP0002249_abnormal_larynx_morphology0.56410002
98MP0001849_ear_inflammation0.55946466
99MP0004085_abnormal_heartbeat0.55070372
100MP0000538_abnormal_urinary_bladder0.54817687

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.49636207
2Protrusio acetabuli (HP:0003179)5.62079508
3Aortic dissection (HP:0002647)5.29723145
4Aortic aneurysm (HP:0004942)5.19513208
5Vascular tortuosity (HP:0004948)4.29104562
6Soft skin (HP:0000977)4.09649196
7Arterial tortuosity (HP:0005116)3.82350094
8Neonatal short-limb short stature (HP:0008921)3.60204450
9Bladder diverticulum (HP:0000015)3.36762237
10Shallow orbits (HP:0000586)3.29873089
11Abnormality of dentin (HP:0010299)3.25213670
12Broad metatarsal (HP:0001783)3.07758335
13Cerebral aneurysm (HP:0004944)3.05441012
14Atrophic scars (HP:0001075)3.00344583
15Follicular hyperkeratosis (HP:0007502)2.92003178
16Coronal craniosynostosis (HP:0004440)2.89556104
17Wide anterior fontanel (HP:0000260)2.85498968
18Ankle contracture (HP:0006466)2.85051172
19Type 1 muscle fiber predominance (HP:0003803)2.77981734
20Bowel diverticulosis (HP:0005222)2.74613366
21Genu recurvatum (HP:0002816)2.73074131
22Hypoplasia of the iris (HP:0007676)2.72520240
23Wormian bones (HP:0002645)2.69372825
24Spinal rigidity (HP:0003306)2.67867517
25Spondylolisthesis (HP:0003302)2.62603997
26Fragile skin (HP:0001030)2.60782716
27Dilatation of the ascending aorta (HP:0005111)2.60767819
28Cervical subluxation (HP:0003308)2.59294386
29Infantile muscular hypotonia (HP:0008947)2.55380987
30Thin ribs (HP:0000883)2.54683911
31Mitral valve prolapse (HP:0001634)2.49953057
32Abnormality of the ischium (HP:0003174)2.49551544
33Hypoplastic ischia (HP:0003175)2.48789079
34Hyperextensible skin (HP:0000974)2.47375146
35Ulnar bowing (HP:0003031)2.42489960
36Blue sclerae (HP:0000592)2.37760574
37Mesomelia (HP:0003027)2.36619574
38Popliteal pterygium (HP:0009756)2.31075196
39Aplasia of the musculature (HP:0100854)2.30800716
40Pulmonary artery stenosis (HP:0004415)2.25752784
41Bell-shaped thorax (HP:0001591)2.19143044
42Overgrowth (HP:0001548)2.18978350
43Aortic regurgitation (HP:0001659)2.18165629
44Delayed gross motor development (HP:0002194)2.17211584
45Mitral regurgitation (HP:0001653)2.16499193
46Absent frontal sinuses (HP:0002688)2.16119168
47Round ear (HP:0100830)2.11734357
48Mild short stature (HP:0003502)2.08410810
49Ectopia lentis (HP:0001083)2.07939051
50Abnormal delivery (HP:0001787)2.05539216
51Limited hip movement (HP:0008800)2.04480228
52Wrist flexion contracture (HP:0001239)2.04041134
53Peritonitis (HP:0002586)2.03853856
54Joint laxity (HP:0001388)2.02698575
55Slender build (HP:0001533)2.00002023
56Biconcave vertebral bodies (HP:0004586)1.97648504
57Increased variability in muscle fiber diameter (HP:0003557)1.96084960
58Broad long bones (HP:0005622)1.95685327
59Mitral stenosis (HP:0001718)1.93174432
60Osteolytic defects of the phalanges of the hand (HP:0009771)1.91593762
61Osteolytic defects of the hand bones (HP:0009699)1.91593762
62White forelock (HP:0002211)1.90544015
63Aortic valve stenosis (HP:0001650)1.90066086
64Hyporeflexia of lower limbs (HP:0002600)1.89544113
65Osteoarthritis (HP:0002758)1.87511369
66Aneurysm (HP:0002617)1.87345869
67Gowers sign (HP:0003391)1.86237124
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85018931
69Nemaline bodies (HP:0003798)1.81711127
70Camptodactyly of toe (HP:0001836)1.80939237
71Partial duplication of the phalanx of hand (HP:0009999)1.79540696
72Deviation of the hallux (HP:0010051)1.79443579
73Breech presentation (HP:0001623)1.77731557
74Pterygium (HP:0001059)1.77432453
75Vitreoretinal degeneration (HP:0000655)1.77048438
76Hypoventilation (HP:0002791)1.76523492
77Calcaneovalgus deformity (HP:0001848)1.73351146
78Renal duplication (HP:0000075)1.70599487
79Deformed tarsal bones (HP:0008119)1.70278670
80Hallux valgus (HP:0001822)1.69660909
81Microglossia (HP:0000171)1.69268418
82Patchy hypopigmentation of hair (HP:0011365)1.68611970
83Long clavicles (HP:0000890)1.68211495
84Vertebral compression fractures (HP:0002953)1.66181857
85Rhizomelia (HP:0008905)1.65692820
86Lipoatrophy (HP:0100578)1.65685090
87Abnormality of the acetabulum (HP:0003170)1.64611371
88Broad phalanx (HP:0006009)1.63534660
89Increased corneal curvature (HP:0100692)1.63367332
90Keratoconus (HP:0000563)1.63367332
91Disproportionate tall stature (HP:0001519)1.62521033
92Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61837505
93Mildly elevated creatine phosphokinase (HP:0008180)1.58948473
94Delayed cranial suture closure (HP:0000270)1.58301816
95Hip contracture (HP:0003273)1.57881634
96Protruding ear (HP:0000411)1.57320008
97Turricephaly (HP:0000262)1.56500378
98Morphological abnormality of the middle ear (HP:0008609)1.56132811
99Inguinal hernia (HP:0000023)1.55275461
100Congenital glaucoma (HP:0001087)1.55182254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.84744803
2MUSK3.53841262
3DDR23.25607799
4LIMK13.07485848
5PDGFRA2.38242564
6EPHB22.20104765
7PAK22.06356342
8PRKD32.03744720
9PTK21.98498289
10PAK31.98488534
11PLK21.98329808
12LATS21.75530430
13TESK11.73162956
14DMPK1.71759205
15NTRK11.71474252
16STK38L1.60934944
17ILK1.60405346
18MAP3K121.51140365
19PAK61.44896022
20ROCK11.43575102
21LATS11.41796343
22TNIK1.41442599
23TRIM281.38766972
24FGFR21.36968757
25PAK41.32608966
26MARK11.31838113
27NEK91.26249049
28ROCK21.25160737
29FER1.23111725
30DAPK31.22099814
31MINK11.17233678
32STK31.16874094
33EPHA41.15253542
34PIK3CG1.11466494
35TGFBR21.10380921
36RIPK11.05040880
37WEE11.04255829
38PRKD21.01557121
39TTN1.01276722
40MET0.99561914
41BCR0.98638522
42BRSK20.98603106
43ERBB30.98274356
44AKT30.94203454
45PDGFRB0.90791061
46PTK2B0.88483579
47CAMK2G0.88206250
48STK380.87324706
49CAMK2D0.84162541
50EIF2AK10.84143520
51PRKCE0.81606682
52GRK50.81591088
53PLK30.80077471
54PRKD10.79642646
55BRSK10.79479124
56GSK3A0.78887010
57MAP2K10.77272221
58PNCK0.75520423
59CAMK2B0.74572603
60CASK0.73892346
61FGFR10.72901810
62MELK0.72733040
63LMTK20.72428541
64ERBB40.70878174
65ABL20.70490756
66STK390.65456491
67PKN20.65356593
68ADRBK10.64802784
69STK240.64348138
70BMPR1B0.64034234
71NUAK10.61741221
72PKN10.60099678
73MAP3K30.54479029
74NTRK20.52761949
75CAMK10.52185790
76MAPKAPK30.51419070
77PAK10.51374814
78TGFBR10.48071790
79MKNK20.47638419
80PRKCG0.46599223
81DYRK1A0.45194935
82PIK3CA0.44956298
83MST40.44877804
84UHMK10.44388590
85BMX0.43830492
86PRKCH0.43674310
87CDK180.43294898
88FLT30.42765194
89CDC42BPA0.42199377
90CAMK2A0.42025592
91TRPM70.38297259
92CDK150.36271094
93MTOR0.36237947
94CSNK1G10.35999369
95CDK140.35090620
96MOS0.33510119
97FRK0.33276466
98CAMK1G0.32630784
99TYRO30.32236271
100NTRK30.31962134

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.53269929
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37290817
3Focal adhesion_Homo sapiens_hsa045102.37121637
4Dilated cardiomyopathy_Homo sapiens_hsa054142.35509920
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27534430
6Hippo signaling pathway_Homo sapiens_hsa043902.04856076
7Adherens junction_Homo sapiens_hsa045202.00584122
8Hedgehog signaling pathway_Homo sapiens_hsa043401.83300492
9Basal cell carcinoma_Homo sapiens_hsa052171.82474697
10Protein digestion and absorption_Homo sapiens_hsa049741.77176372
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.73090277
12Proteoglycans in cancer_Homo sapiens_hsa052051.66571117
13Tight junction_Homo sapiens_hsa045301.64895385
14Vitamin B6 metabolism_Homo sapiens_hsa007501.62839669
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59744664
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57392024
17TGF-beta signaling pathway_Homo sapiens_hsa043501.47314404
18Melanogenesis_Homo sapiens_hsa049161.44164034
19Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36333724
20Wnt signaling pathway_Homo sapiens_hsa043101.29755022
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26763550
22Axon guidance_Homo sapiens_hsa043601.26756196
23Fatty acid elongation_Homo sapiens_hsa000621.20046586
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.17128505
25Gap junction_Homo sapiens_hsa045401.15988821
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15616308
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13835606
28Amoebiasis_Homo sapiens_hsa051461.13654822
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11791773
30Melanoma_Homo sapiens_hsa052181.11628323
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10654041
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08249029
33beta-Alanine metabolism_Homo sapiens_hsa004101.06644708
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06438360
35Propanoate metabolism_Homo sapiens_hsa006401.05153679
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02320334
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99239854
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98096068
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96144039
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93284082
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92180420
42Vibrio cholerae infection_Homo sapiens_hsa051100.89412344
43Circadian rhythm_Homo sapiens_hsa047100.89354987
44Arginine and proline metabolism_Homo sapiens_hsa003300.89132497
45MicroRNAs in cancer_Homo sapiens_hsa052060.87153702
46Rap1 signaling pathway_Homo sapiens_hsa040150.85837257
47Cocaine addiction_Homo sapiens_hsa050300.85797594
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84876690
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83215063
50PPAR signaling pathway_Homo sapiens_hsa033200.80565295
51Protein export_Homo sapiens_hsa030600.77957549
52Pathways in cancer_Homo sapiens_hsa052000.77282163
53Small cell lung cancer_Homo sapiens_hsa052220.77083149
54Pyruvate metabolism_Homo sapiens_hsa006200.74029863
55Circadian entrainment_Homo sapiens_hsa047130.72560818
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.72342658
57Steroid biosynthesis_Homo sapiens_hsa001000.72042287
58cAMP signaling pathway_Homo sapiens_hsa040240.70139043
59Glutathione metabolism_Homo sapiens_hsa004800.69736054
60Sulfur metabolism_Homo sapiens_hsa009200.68754362
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68081191
62Oxytocin signaling pathway_Homo sapiens_hsa049210.66484441
63Gastric acid secretion_Homo sapiens_hsa049710.66137715
64GABAergic synapse_Homo sapiens_hsa047270.63575851
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62210638
66Glioma_Homo sapiens_hsa052140.61929194
67Insulin secretion_Homo sapiens_hsa049110.61649435
68Renin secretion_Homo sapiens_hsa049240.61615710
69Thyroid hormone synthesis_Homo sapiens_hsa049180.60625510
70Endocytosis_Homo sapiens_hsa041440.59395061
71Prostate cancer_Homo sapiens_hsa052150.58459960
72Dopaminergic synapse_Homo sapiens_hsa047280.57975857
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57680942
74Sphingolipid metabolism_Homo sapiens_hsa006000.57382245
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56966950
76Histidine metabolism_Homo sapiens_hsa003400.56330934
77Calcium signaling pathway_Homo sapiens_hsa040200.55558280
78Amphetamine addiction_Homo sapiens_hsa050310.54900425
79AMPK signaling pathway_Homo sapiens_hsa041520.54008956
80Glutamatergic synapse_Homo sapiens_hsa047240.53603624
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.53138781
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52862029
83Ras signaling pathway_Homo sapiens_hsa040140.52114220
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.51966061
85Endometrial cancer_Homo sapiens_hsa052130.49743343
86Fatty acid metabolism_Homo sapiens_hsa012120.47920130
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47906591
88Platelet activation_Homo sapiens_hsa046110.47645043
89Cardiac muscle contraction_Homo sapiens_hsa042600.47021666
90Fatty acid degradation_Homo sapiens_hsa000710.45520718
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45138473
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43644347
93Cholinergic synapse_Homo sapiens_hsa047250.43385892
94Synaptic vesicle cycle_Homo sapiens_hsa047210.40758914
95Colorectal cancer_Homo sapiens_hsa052100.40259256
96Folate biosynthesis_Homo sapiens_hsa007900.40254522
97Salivary secretion_Homo sapiens_hsa049700.38088674
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37842120
99Lysine degradation_Homo sapiens_hsa003100.37063988
100Sulfur relay system_Homo sapiens_hsa041220.36895784

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