ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	central nervous system myelination (GO:0022010)	4.83454373
2	axon ensheathment in central nervous system (GO:0032291)	4.83454373
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.63767997
4	axonemal dynein complex assembly (GO:0070286)	4.63367479
5	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.10663102
6	synaptic vesicle maturation (GO:0016188)	3.97147531
7	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.93439617
8	cerebral cortex neuron differentiation (GO:0021895)	3.86268007
9	glutamate secretion (GO:0014047)	3.80834479
10	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.73477096
11	sleep (GO:0030431)	3.50617425
12	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.48383061
13	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.47870956
14	neuronal action potential propagation (GO:0019227)	3.44204674
15	gamma-aminobutyric acid transport (GO:0015812)	3.44191076
16	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.44037754
17	urinary tract smooth muscle contraction (GO:0014848)	3.42816527
18	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.32187091
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31852159
20	synaptic vesicle exocytosis (GO:0016079)	3.31672515
21	regulation of cilium movement (GO:0003352)	3.27020474
22	regulation of neuronal synaptic plasticity (GO:0048168)	3.22407636
23	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.21643273
24	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.18481851
25	regulation of synapse structural plasticity (GO:0051823)	3.18230382
26	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.15842207
27	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.15267737
28	negative regulation of inclusion body assembly (GO:0090084)	3.14483404
29	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.11867755
30	activation of protein kinase A activity (GO:0034199)	3.09788339
31	cellular potassium ion homeostasis (GO:0030007)	3.07561452
32	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.03285782
33	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.01926469
34	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.01283506
35	sodium ion export (GO:0071436)	2.97845238
36	regulation of synaptic vesicle exocytosis (GO:2000300)	2.96543688
37	detection of calcium ion (GO:0005513)	2.95915774
38	regulation of cell communication by electrical coupling (GO:0010649)	2.93413013
39	cilium or flagellum-dependent cell motility (GO:0001539)	2.92912788
40	negative regulation of astrocyte differentiation (GO:0048712)	2.91633227
41	regulation of ARF protein signal transduction (GO:0032012)	2.88341529
42	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.83309541
43	L-amino acid import (GO:0043092)	2.81118294
44	neurotransmitter secretion (GO:0007269)	2.79522129
45	vocalization behavior (GO:0071625)	2.75794432
46	neuroblast proliferation (GO:0007405)	2.74659660
47	cell communication by electrical coupling (GO:0010644)	2.70911682
48	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.70686997
49	cardiac muscle hypertrophy (GO:0003300)	2.68453496
50	cilium movement (GO:0003341)	2.68355634
51	cardiac muscle contraction (GO:0060048)	2.67528952
52	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.66686562
53	muscle hypertrophy in response to stress (GO:0003299)	2.66686562
54	cardiac muscle adaptation (GO:0014887)	2.66686562
55	cGMP-mediated signaling (GO:0019934)	2.62769514
56	cerebellar granule cell differentiation (GO:0021707)	2.62661293
57	striated muscle hypertrophy (GO:0014897)	2.61563633
58	regulation of microtubule-based movement (GO:0060632)	2.60553493
59	regulation of synaptic vesicle transport (GO:1902803)	2.60034186
60	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.58362870
61	positive regulation of synapse maturation (GO:0090129)	2.57814252
62	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.54420136
63	regulation of synaptic plasticity (GO:0048167)	2.54236718
64	motile cilium assembly (GO:0044458)	2.52889234
65	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.50838163
66	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.50253052
67	artery smooth muscle contraction (GO:0014824)	2.49697240
68	SMAD protein complex assembly (GO:0007183)	2.49531759
69	cellular response to thyroid hormone stimulus (GO:0097067)	2.49525046
70	signal complex assembly (GO:0007172)	2.46573292
71	negative regulation of erythrocyte differentiation (GO:0045647)	2.45972850
72	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.44297058
73	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.42422564
74	regulation of calcium ion transmembrane transport (GO:1903169)	2.42422564
75	membrane depolarization during action potential (GO:0086010)	2.40972541
76	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.40135770
77	potassium ion export (GO:0071435)	2.39999581
78	neuromuscular process controlling posture (GO:0050884)	2.39507753
79	muscle hypertrophy (GO:0014896)	2.39418386
80	regulation of actin filament-based movement (GO:1903115)	2.37978918
81	neurotransmitter-gated ion channel clustering (GO:0072578)	2.37190001
82	adenosine receptor signaling pathway (GO:0001973)	2.36997174
83	cell communication involved in cardiac conduction (GO:0086065)	2.35197515
84	regulation of voltage-gated calcium channel activity (GO:1901385)	2.34914481
85	vesicle docking (GO:0048278)	2.33707074
86	glutamate receptor signaling pathway (GO:0007215)	2.33643173
87	tonic smooth muscle contraction (GO:0014820)	2.32931423
88	vesicle docking involved in exocytosis (GO:0006904)	2.32673095
89	response to gravity (GO:0009629)	2.29335791
90	apical protein localization (GO:0045176)	2.27799657
91	amino acid import (GO:0043090)	2.26587421
92	histone H4-K12 acetylation (GO:0043983)	2.26432582
93	regulation of inclusion body assembly (GO:0090083)	2.23982296
94	epithelial cilium movement (GO:0003351)	2.23598672
95	long term synaptic depression (GO:0060292)	2.23232035
96	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.22334688
97	layer formation in cerebral cortex (GO:0021819)	2.22174194
98	cellular response to epinephrine stimulus (GO:0071872)	2.21618185
99	exploration behavior (GO:0035640)	2.21540135
100	brain morphogenesis (GO:0048854)	2.20189941

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	DROSHA_22980978_ChIP-Seq_HELA_Human	2.62959903
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.61972343
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.52424479
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.40216557
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.29340199
6	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.11568201
7	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.05238472
8	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.03911353
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.01991173
10	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.98410787
11	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.93164467
12	GBX2_23144817_ChIP-Seq_PC3_Human	1.88808584
13	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.81023151
14	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.80647451
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70949022
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.63087280
17	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.62525592
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.62337981
19	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.61117771
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.60988239
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57728940
22	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57728940
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.54971872
24	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.52806542
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.51782496
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.49397857
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.49031275
28	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.44890918
29	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.36061479
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.35454186
31	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32750499
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32487330
33	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.25751137
34	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.25076076
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24429002
36	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.23307763
37	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.21271399
38	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.18741829
39	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.11000656
40	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.10137399
41	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.09471382
42	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.09063959
43	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.07878775
44	KDM2B_26808549_Chip-Seq_K562_Human	1.07696888
45	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.07394330
46	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.06079472
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03999837
48	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.03204097
49	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01160301
50	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00020756
51	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00003089
52	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.99194328
53	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.98939018
54	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.97794512
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.96777621
56	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.96455387
57	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96064382
58	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94988842
59	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.94539751
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94481767
61	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93754433
62	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.92701520
63	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.92701520
64	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.92623966
65	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.92078273
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91300253
67	TP53_16413492_ChIP-PET_HCT116_Human	0.89882949
68	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.89818064
69	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.89214565
70	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.88415513
71	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.87023565
72	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.86733817
73	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.85980430
74	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.85045446
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84896803
76	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.84228201
77	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.84228201
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83804883
79	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.82950918
80	CJUN_26792858_Chip-Seq_BT549_Human	0.82763843
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.82377395
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.82035573
83	TP53_18474530_ChIP-ChIP_U2OS_Human	0.80112238
84	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.79493869
85	GATA1_19941826_ChIP-Seq_K562_Human	0.79206495
86	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.78980079
87	SMC4_20622854_ChIP-Seq_HELA_Human	0.78405790
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77723124
89	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.77559347
90	AR_19668381_ChIP-Seq_PC3_Human	0.76984697
91	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.76694372
92	* LXR_22292898_ChIP-Seq_THP-1_Human	0.76449067
93	VDR_24787735_ChIP-Seq_THP-1_Human	0.76365379
94	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75190533
95	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.74645385
96	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.74608503
97	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.73161604
98	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.72718909
99	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.72352946
100	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.71432689

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.18501546
2	MP0000751_myopathy	2.95767489
3	MP0003635_abnormal_synaptic_transmissio	2.70558611
4	MP0002064_seizures	2.54898928
5	MP0004510_myositis	2.52830042
6	MP0009745_abnormal_behavioral_response	2.49956412
7	MP0004270_analgesia	2.49938734
8	MP0003329_amyloid_beta_deposits	2.42846222
9	MP0004084_abnormal_cardiac_muscle	2.22904574
10	MP0003075_altered_response_to	2.05991550
11	MP0002272_abnormal_nervous_system	2.03406946
12	MP0002063_abnormal_learning/memory/cond	2.01935575
13	MP0000604_amyloidosis	1.99860218
14	MP0004215_abnormal_myocardial_fiber	1.95648220
15	MP0002837_dystrophic_cardiac_calcinosis	1.94273144
16	MP0009046_muscle_twitch	1.93011493
17	MP0005423_abnormal_somatic_nervous	1.87835076
18	MP0002735_abnormal_chemical_nociception	1.87804152
19	MP0003136_yellow_coat_color	1.87355978
20	MP0004036_abnormal_muscle_relaxation	1.86807958
21	MP0009780_abnormal_chondrocyte_physiolo	1.83591682
22	MP0002734_abnormal_mechanical_nocicepti	1.81987556
23	MP0003880_abnormal_central_pattern	1.80654749
24	MP0002572_abnormal_emotion/affect_behav	1.76790086
25	MP0000749_muscle_degeneration	1.74580102
26	MP0001501_abnormal_sleep_pattern	1.67614346
27	MP0008569_lethality_at_weaning	1.67476030
28	MP0003690_abnormal_glial_cell	1.64821199
29	MP0003183_abnormal_peptide_metabolism	1.63171042
30	MP0001984_abnormal_olfaction	1.62826411
31	MP0001970_abnormal_pain_threshold	1.61201424
32	MP0003633_abnormal_nervous_system	1.59396167
33	MP0001486_abnormal_startle_reflex	1.57853614
34	MP0002733_abnormal_thermal_nociception	1.53825565
35	MP0003828_pulmonary_edema	1.53637257
36	MP0003879_abnormal_hair_cell	1.53207805
37	MP0002332_abnormal_exercise_endurance	1.52388282
38	MP0002972_abnormal_cardiac_muscle	1.48664378
39	MP0005623_abnormal_meninges_morphology	1.47005781
40	MP0000465_gastrointestinal_hemorrhage	1.45683760
41	MP0001968_abnormal_touch/_nociception	1.45317104
42	MP0006138_congestive_heart_failure	1.42944588
43	MP0005165_increased_susceptibility_to	1.41665790
44	MP0000343_altered_response_to	1.41294754
45	MP0005620_abnormal_muscle_contractility	1.37637498
46	MP0005330_cardiomyopathy	1.31747561
47	MP0003045_fibrosis	1.30693650
48	MP0003634_abnormal_glial_cell	1.28568532
49	MP0004484_altered_response_of	1.27940193
50	MP0005646_abnormal_pituitary_gland	1.27551057
51	MP0001440_abnormal_grooming_behavior	1.25226538
52	MP0001502_abnormal_circadian_rhythm	1.24802882
53	MP0002653_abnormal_ependyma_morphology	1.24342787
54	MP0004087_abnormal_muscle_fiber	1.23691404
55	MP0008004_abnormal_stomach_pH	1.23363059
56	MP0004233_abnormal_muscle_weight	1.23084239
57	MP0010368_abnormal_lymphatic_system	1.19014792
58	MP0002067_abnormal_sensory_capabilities	1.18620837
59	MP0005464_abnormal_platelet_physiology	1.18081149
60	MP0000920_abnormal_myelination	1.17876144
61	MP0003631_nervous_system_phenotype	1.17721958
62	MP0003172_abnormal_lysosome_physiology	1.15548554
63	MP0004130_abnormal_muscle_cell	1.14395509
64	MP0000569_abnormal_digit_pigmentation	1.13154999
65	MP0001851_eye_inflammation	1.12236901
66	MP0005058_abnormal_lysosome_morphology	1.11151647
67	MP0002896_abnormal_bone_mineralization	1.10279045
68	MP0000747_muscle_weakness	1.06069110
69	MP0005503_abnormal_tendon_morphology	1.05904516
70	MP0004145_abnormal_muscle_electrophysio	1.01538923
71	MP0002269_muscular_atrophy	1.01029683
72	MP0000759_abnormal_skeletal_muscle	0.99913975
73	MP0010678_abnormal_skin_adnexa	0.99730186
74	MP0008438_abnormal_cutaneous_collagen	0.99288367
75	MP0003137_abnormal_impulse_conducting	0.97917217
76	MP0002106_abnormal_muscle_physiology	0.94510427
77	MP0004085_abnormal_heartbeat	0.93440767
78	MP0002066_abnormal_motor_capabilities/c	0.92464123
79	MP0008874_decreased_physiological_sensi	0.91429632
80	MP0000750_abnormal_muscle_regeneration	0.89884155
81	MP0005410_abnormal_fertilization	0.89809636
82	MP0005166_decreased_susceptibility_to	0.89349576
83	MP0003646_muscle_fatigue	0.86112522
84	MP0002736_abnormal_nociception_after	0.84612884
85	MP0005595_abnormal_vascular_smooth	0.82733666
86	MP0001765_abnormal_ion_homeostasis	0.82527486
87	MP0010630_abnormal_cardiac_muscle	0.81487108
88	MP0005385_cardiovascular_system_phenoty	0.80766602
89	MP0001544_abnormal_cardiovascular_syste	0.80766602
90	MP0002229_neurodegeneration	0.77900502
91	MP0004885_abnormal_endolymph	0.77823639
92	MP0009384_cardiac_valve_regurgitation	0.77562274
93	MP0005670_abnormal_white_adipose	0.77128049
94	MP0002971_abnormal_brown_adipose	0.75329386
95	MP0005369_muscle_phenotype	0.74888116
96	MP0005535_abnormal_body_temperature	0.74292113
97	MP0005666_abnormal_adipose_tissue	0.74209431
98	MP0010234_abnormal_vibrissa_follicle	0.74024105
99	MP0002882_abnormal_neuron_morphology	0.73711805
100	MP0004811_abnormal_neuron_physiology	0.73345429

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.51168208
2	Focal motor seizures (HP:0011153)	5.17877846
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.85943832
4	Abnormal respiratory motile cilium morphology (HP:0005938)	4.85943832
5	Atonic seizures (HP:0010819)	4.79557288
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.79546367
7	Absent/shortened dynein arms (HP:0200106)	4.79546367
8	Action tremor (HP:0002345)	3.93439241
9	Abnormal respiratory motile cilium physiology (HP:0012261)	3.82167165
10	Muscle fiber splitting (HP:0003555)	3.76014403
11	Abnormal ciliary motility (HP:0012262)	3.72544168
12	Febrile seizures (HP:0002373)	3.48183450
13	Focal seizures (HP:0007359)	3.38953906
14	Absence seizures (HP:0002121)	3.24535609
15	Rhinitis (HP:0012384)	3.20669983
16	Hemiplegia (HP:0002301)	3.15796218
17	Sudden death (HP:0001699)	3.15382018
18	Hyporeflexia of lower limbs (HP:0002600)	2.98068338
19	Neurofibrillary tangles (HP:0002185)	2.96729702
20	Generalized tonic-clonic seizures (HP:0002069)	2.94497707
21	Myokymia (HP:0002411)	2.92504132
22	Progressive cerebellar ataxia (HP:0002073)	2.79930785
23	Nasal polyposis (HP:0100582)	2.77704860
24	Bundle branch block (HP:0011710)	2.76270718
25	Exercise-induced myalgia (HP:0003738)	2.75852096
26	Supranuclear gaze palsy (HP:0000605)	2.75615396
27	Papilledema (HP:0001085)	2.71064930
28	Abnormality of glycolipid metabolism (HP:0010969)	2.70523631
29	Abnormality of liposaccharide metabolism (HP:0010968)	2.70523631
30	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.70523631
31	Dialeptic seizures (HP:0011146)	2.67831562
32	Diplopia (HP:0000651)	2.64063963
33	Abnormality of binocular vision (HP:0011514)	2.64063963
34	Abnormality of the nasal mucosa (HP:0000433)	2.58863753
35	Ankle clonus (HP:0011448)	2.55336140
36	Distal lower limb muscle weakness (HP:0009053)	2.52232934
37	Mutism (HP:0002300)	2.50828135
38	Hemiparesis (HP:0001269)	2.49956952
39	Asymmetric septal hypertrophy (HP:0001670)	2.47453660
40	Truncal ataxia (HP:0002078)	2.47335041
41	Cerebral inclusion bodies (HP:0100314)	2.46237708
42	Syncope (HP:0001279)	2.39512742
43	EMG: myopathic abnormalities (HP:0003458)	2.29979988
44	Atrial fibrillation (HP:0005110)	2.26768319
45	Bronchiectasis (HP:0002110)	2.23633147
46	Diminished motivation (HP:0000745)	2.22157518
47	Tubulointerstitial nephritis (HP:0001970)	2.22042016
48	Primary atrial arrhythmia (HP:0001692)	2.21193239
49	Rimmed vacuoles (HP:0003805)	2.21047624
50	Apathy (HP:0000741)	2.20021219
51	Type 1 muscle fiber predominance (HP:0003803)	2.15805418
52	Purpura (HP:0000979)	2.12859765
53	Epileptic encephalopathy (HP:0200134)	2.10560905
54	Abnormality of dentin (HP:0010299)	2.10300841
55	Supraventricular tachycardia (HP:0004755)	2.08623145
56	Muscle fiber inclusion bodies (HP:0100299)	2.08070505
57	Lower limb muscle weakness (HP:0007340)	2.07461826
58	Delusions (HP:0000746)	2.06318669
59	Chronic bronchitis (HP:0004469)	2.05732152
60	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.04169712
61	Nemaline bodies (HP:0003798)	2.02342745
62	Abnormality of the vocal cords (HP:0008777)	2.02268266
63	Abnormality of the periventricular white matter (HP:0002518)	2.01469753
64	Status epilepticus (HP:0002133)	2.00893803
65	Supraventricular arrhythmia (HP:0005115)	2.00683020
66	Ventricular fibrillation (HP:0001663)	1.99615009
67	Increased variability in muscle fiber diameter (HP:0003557)	1.98274451
68	Ventricular arrhythmia (HP:0004308)	1.95205644
69	Abnormality of the calf musculature (HP:0001430)	1.95099180
70	Obstructive sleep apnea (HP:0002870)	1.93846004
71	Dysostosis multiplex (HP:0000943)	1.91121112
72	Abnormality of skeletal muscle fiber size (HP:0012084)	1.90815745
73	Rapidly progressive (HP:0003678)	1.89355611
74	Neuronal loss in central nervous system (HP:0002529)	1.86745101
75	Difficulty climbing stairs (HP:0003551)	1.86561519
76	Postural instability (HP:0002172)	1.83914827
77	Rigidity (HP:0002063)	1.83745209
78	Broad distal phalanx of finger (HP:0009836)	1.82460485
79	Prolonged bleeding time (HP:0003010)	1.81494019
80	Amyotrophic lateral sclerosis (HP:0007354)	1.80929615
81	Atelectasis (HP:0100750)	1.79780310
82	Distal arthrogryposis (HP:0005684)	1.78651005
83	EMG: neuropathic changes (HP:0003445)	1.77754689
84	Depression (HP:0000716)	1.77372759
85	Abnormal EKG (HP:0003115)	1.75563457
86	Foot dorsiflexor weakness (HP:0009027)	1.74583129
87	Intention tremor (HP:0002080)	1.74039648
88	Increased mean platelet volume (HP:0011877)	1.72926512
89	Abnormal atrioventricular conduction (HP:0005150)	1.72095804
90	Menorrhagia (HP:0000132)	1.71278667
91	Bulbar palsy (HP:0001283)	1.70957576
92	Heart block (HP:0012722)	1.70506421
93	Increased connective tissue (HP:0009025)	1.69685656
94	Axonal loss (HP:0003447)	1.69180083
95	Ventricular tachycardia (HP:0004756)	1.69145635
96	Lower limb amyotrophy (HP:0007210)	1.69105267
97	Lipoatrophy (HP:0100578)	1.66239750
98	Atrioventricular block (HP:0001678)	1.65833850
99	Nuclear cataract (HP:0100018)	1.65048458
100	Abnormal platelet volume (HP:0011876)	1.62875358

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.19496429
2	DAPK2	2.92497187
3	MAPK15	2.88186562
4	EPHA4	2.37303873
5	MARK1	2.25161524
6	CAMKK1	2.07851699
7	PHKG1	1.98696422
8	PHKG2	1.98696422
9	BLK	1.88686372
10	PAK6	1.88671185
11	CAMKK2	1.86972204
12	NTRK3	1.85927818
13	ARAF	1.85149177
14	MAP3K13	1.76873732
15	PTK2B	1.76858583
16	TTN	1.71192525
17	MARK2	1.66728477
18	WNK1	1.63701920
19	OBSCN	1.60324750
20	MAPK12	1.59771398
21	PRPF4B	1.50954412
22	RIPK4	1.36325761
23	NTRK1	1.27281805
24	CAMK1	1.25173530
25	MYLK	1.22695239
26	GRK7	1.22057028
27	PINK1	1.20207235
28	RIPK1	1.11654891
29	PDPK1	1.10688131
30	STK39	1.10048506
31	MAP3K7	1.08434392
32	STK38	1.07202139
33	WNK4	1.06660967
34	TESK1	1.04433735
35	UHMK1	1.04320118
36	CAMK2A	1.04205501
37	NEK9	1.01780453
38	PKN1	0.99698326
39	PDK1	0.98789196
40	MOS	0.97051855
41	CAMK2B	0.95633607
42	KSR2	0.95235540
43	MAPK7	0.94477431
44	PRKCG	0.94397427
45	BMX	0.92870063
46	CDC42BPA	0.90566620
47	TAOK1	0.90210114
48	GRK5	0.89858427
49	PRKD3	0.89044738
50	CDK5	0.88079374
51	NTRK2	0.82913269
52	MINK1	0.81956699
53	ROCK1	0.81881084
54	CAMK2G	0.80860336
55	TRPM7	0.80774544
56	CAMK4	0.79661829
57	TRIB3	0.79484014
58	CAMK2D	0.76394901
59	LIMK1	0.76372210
60	MAP2K4	0.76290103
61	MAP3K9	0.76055454
62	PLK2	0.75681592
63	TBK1	0.75043864
64	DDR2	0.74850912
65	EPHB1	0.73659285
66	LATS2	0.72743576
67	DAPK1	0.70129608
68	SGK1	0.69409585
69	PRKCE	0.67831754
70	CDK19	0.65536157
71	DAPK3	0.65408189
72	CASK	0.65160213
73	CCNB1	0.65043539
74	PRKCQ	0.64585424
75	DYRK1A	0.64076610
76	ROCK2	0.62889408
77	PDGFRB	0.62586512
78	MAP3K11	0.61819190
79	SIK2	0.61192794
80	BMPR2	0.60064685
81	TAOK2	0.60003184
82	MAP2K6	0.59829112
83	PRKD1	0.58676129
84	MAP2K3	0.58512144
85	MAPK10	0.58425354
86	PRKD2	0.57450127
87	STK11	0.57014272
88	MET	0.55048671
89	ZAP70	0.54357197
90	FGR	0.52898329
91	MAP3K12	0.52697399
92	DMPK	0.51980310
93	MAP3K1	0.51502898
94	IRAK2	0.51499849
95	DYRK1B	0.50934851
96	MAP3K5	0.50811921
97	PRKCH	0.49723652
98	MAP2K7	0.49032484
99	PRKG1	0.48014805
100	TGFBR2	0.47463678

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.46443953
2	GABAergic synapse_Homo sapiens_hsa04727	2.18376312
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.10231691
4	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.09186116
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.09026676
6	Long-term potentiation_Homo sapiens_hsa04720	1.94336192
7	Circadian entrainment_Homo sapiens_hsa04713	1.86746509
8	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.85183681
9	Morphine addiction_Homo sapiens_hsa05032	1.80220399
10	Amphetamine addiction_Homo sapiens_hsa05031	1.76209664
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.74163597
12	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.69972371
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.66664673
14	Renin secretion_Homo sapiens_hsa04924	1.62922314
15	Gastric acid secretion_Homo sapiens_hsa04971	1.60885907
16	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.58569552
17	Insulin secretion_Homo sapiens_hsa04911	1.55095214
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.54398272
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.51226044
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.50419328
21	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.47899468
22	Cocaine addiction_Homo sapiens_hsa05030	1.47656461
23	Salivary secretion_Homo sapiens_hsa04970	1.43323295
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.39947664
25	Circadian rhythm_Homo sapiens_hsa04710	1.39933537
26	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.34560691
27	cAMP signaling pathway_Homo sapiens_hsa04024	1.29299608
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.26416508
29	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.24116060
30	Estrogen signaling pathway_Homo sapiens_hsa04915	1.24106942
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.24095364
32	Cholinergic synapse_Homo sapiens_hsa04725	1.24048804
33	GnRH signaling pathway_Homo sapiens_hsa04912	1.16669129
34	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.16174392
35	Gap junction_Homo sapiens_hsa04540	1.13399377
36	Platelet activation_Homo sapiens_hsa04611	1.12448772
37	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.11690510
38	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.08373807
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.08151767
40	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.03623503
41	ECM-receptor interaction_Homo sapiens_hsa04512	0.98290932
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94974631
43	Lysosome_Homo sapiens_hsa04142	0.93254335
44	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90853876
45	Serotonergic synapse_Homo sapiens_hsa04726	0.90676518
46	Taste transduction_Homo sapiens_hsa04742	0.90538021
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.89603671
48	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.89156809
49	Olfactory transduction_Homo sapiens_hsa04740	0.84108245
50	Amoebiasis_Homo sapiens_hsa05146	0.83141931
51	Glioma_Homo sapiens_hsa05214	0.80699013
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.80638103
53	Focal adhesion_Homo sapiens_hsa04510	0.79856989
54	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.75800825
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.75403399
56	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73566355
57	Pancreatic secretion_Homo sapiens_hsa04972	0.72345009
58	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.71722690
59	VEGF signaling pathway_Homo sapiens_hsa04370	0.71603239
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.70367793
61	Osteoclast differentiation_Homo sapiens_hsa04380	0.69506164
62	ErbB signaling pathway_Homo sapiens_hsa04012	0.68588449
63	Endocytosis_Homo sapiens_hsa04144	0.67930803
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.67029351
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66830832
66	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.65687829
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.63890462
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.62720159
69	Prion diseases_Homo sapiens_hsa05020	0.62671736
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62621796
71	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.61630001
72	Melanogenesis_Homo sapiens_hsa04916	0.60224763
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.59800473
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.58201247
75	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.57529448
76	Other glycan degradation_Homo sapiens_hsa00511	0.56990052
77	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.56193611
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55324221
79	Long-term depression_Homo sapiens_hsa04730	0.55067656
80	Regulation of autophagy_Homo sapiens_hsa04140	0.54505119
81	Chemokine signaling pathway_Homo sapiens_hsa04062	0.54478856
82	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.54399580
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.53308752
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.52707083
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.51666351
86	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.49597725
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.49562758
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48855670
89	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47866898
90	Bile secretion_Homo sapiens_hsa04976	0.47670502
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47461342
92	Glucagon signaling pathway_Homo sapiens_hsa04922	0.47275039
93	Phagosome_Homo sapiens_hsa04145	0.47265488
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.46997727
95	Axon guidance_Homo sapiens_hsa04360	0.46177481
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45776646
97	Renal cell carcinoma_Homo sapiens_hsa05211	0.45684263
98	Ras signaling pathway_Homo sapiens_hsa04014	0.45622840
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45318345
100	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.45186776

C1ORF204

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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