C1ORF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)6.45021306
2muscle filament sliding (GO:0030049)5.53896534
3actin-myosin filament sliding (GO:0033275)5.53896534
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.03696872
5regulation of skeletal muscle contraction (GO:0014819)4.57340722
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.56017949
7actin-mediated cell contraction (GO:0070252)4.55508079
8regulation of relaxation of muscle (GO:1901077)4.49408491
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.48275875
10skeletal muscle contraction (GO:0003009)4.35220680
11cellular potassium ion homeostasis (GO:0030007)4.19134012
12myofibril assembly (GO:0030239)4.12556303
13sodium ion export (GO:0071436)4.05292213
14striated muscle contraction (GO:0006941)4.03891644
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.98238503
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.94939304
17creatine metabolic process (GO:0006600)3.92491723
18regulation of actin filament-based movement (GO:1903115)3.85906331
19response to inactivity (GO:0014854)3.82380968
20regulation of cell communication by electrical coupling (GO:0010649)3.81594178
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.81030030
22cardiac myofibril assembly (GO:0055003)3.74002641
23cardiac muscle contraction (GO:0060048)3.67745575
24actin filament-based movement (GO:0030048)3.63546244
25synaptic vesicle maturation (GO:0016188)3.62209721
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61997133
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.58566803
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57756475
29regulation of synaptic vesicle exocytosis (GO:2000300)3.56141352
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.54200280
31neuronal action potential propagation (GO:0019227)3.47940502
32postsynaptic membrane organization (GO:0001941)3.47926479
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.29968257
34skeletal muscle fiber development (GO:0048741)3.26809216
35cell communication by electrical coupling (GO:0010644)3.25251057
36sarcomere organization (GO:0045214)3.21738729
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.16595768
38cell communication involved in cardiac conduction (GO:0086065)3.11491022
39regulation of synaptic vesicle transport (GO:1902803)3.10631326
40muscle contraction (GO:0006936)3.10008746
41regulation of female receptivity (GO:0045924)3.08447895
42potassium ion import (GO:0010107)3.08110570
43striated muscle hypertrophy (GO:0014897)3.07928579
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06042128
45myotube cell development (GO:0014904)3.05486572
46cardiac muscle hypertrophy (GO:0003300)3.04857957
47regulation of calcium ion transmembrane transporter activity (GO:1901019)3.01659747
48regulation of calcium ion transmembrane transport (GO:1903169)3.01659747
49relaxation of muscle (GO:0090075)3.01008101
50positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.99406202
51locomotory exploration behavior (GO:0035641)2.98965839
52cGMP-mediated signaling (GO:0019934)2.98782220
53vocalization behavior (GO:0071625)2.97038263
54regulation of membrane repolarization (GO:0060306)2.95946244
55glutamate secretion (GO:0014047)2.93012550
56regulation of cardiac muscle cell contraction (GO:0086004)2.92898758
57response to muscle activity (GO:0014850)2.92094461
58skeletal muscle adaptation (GO:0043501)2.91410801
59negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.90069858
60negative regulation of calcium ion transmembrane transport (GO:1903170)2.90069858
61muscle hypertrophy (GO:0014896)2.88783328
62neuromuscular synaptic transmission (GO:0007274)2.86626702
63muscle system process (GO:0003012)2.86167052
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85291631
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82564734
66actomyosin structure organization (GO:0031032)2.80936741
67cellular sodium ion homeostasis (GO:0006883)2.80273140
68regulation of voltage-gated calcium channel activity (GO:1901385)2.79205097
69cerebellar granule cell differentiation (GO:0021707)2.78423954
70neuronal ion channel clustering (GO:0045161)2.78224877
71negative regulation of protein localization to cell surface (GO:2000009)2.75916757
72relaxation of cardiac muscle (GO:0055119)2.73831263
73NADH metabolic process (GO:0006734)2.73829223
74synaptic vesicle exocytosis (GO:0016079)2.71849887
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70170245
76female mating behavior (GO:0060180)2.69495069
77neuron cell-cell adhesion (GO:0007158)2.69402943
78negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67954371
79L-amino acid import (GO:0043092)2.65900655
80plasma membrane repair (GO:0001778)2.65703738
81regulation of synapse structural plasticity (GO:0051823)2.64060030
82presynaptic membrane organization (GO:0097090)2.62105924
83potassium ion homeostasis (GO:0055075)2.60572958
84striated muscle adaptation (GO:0014888)2.60304985
85peripheral nervous system axon ensheathment (GO:0032292)2.60149755
86myelination in peripheral nervous system (GO:0022011)2.60149755
87otic vesicle formation (GO:0030916)2.59351943
88neuromuscular process controlling balance (GO:0050885)2.59310477
89muscle fiber development (GO:0048747)2.58893865
90regulation of glutamate receptor signaling pathway (GO:1900449)2.55211888
91regulation of skeletal muscle cell differentiation (GO:2001014)2.54310606
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51860069
93exploration behavior (GO:0035640)2.51521148
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47069909
95muscle cell cellular homeostasis (GO:0046716)2.46676376
96cardiac muscle hypertrophy in response to stress (GO:0014898)2.46658610
97muscle hypertrophy in response to stress (GO:0003299)2.46658610
98cardiac muscle adaptation (GO:0014887)2.46658610
99presynaptic membrane assembly (GO:0097105)2.45132407
100fructose metabolic process (GO:0006000)2.44691460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17885573
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.29291382
3EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26468205
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26468205
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26121397
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23532268
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14157964
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12368659
9* ESR2_21235772_ChIP-Seq_MCF-7_Human2.08282592
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06605771
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03810163
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03244625
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.03160456
14DROSHA_22980978_ChIP-Seq_HELA_Human2.02725048
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99189871
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95397608
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95197130
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.94327339
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.93542756
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86994218
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83456008
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.78145546
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76914706
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.70930312
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69501132
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.68186715
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59411651
28GBX2_23144817_ChIP-Seq_PC3_Human1.59149770
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58520489
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.58220653
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.55393018
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48836452
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48695659
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47436525
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44319527
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40466107
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.39451876
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37652507
39REST_21632747_ChIP-Seq_MESCs_Mouse1.36862612
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35818091
41* ESR1_21235772_ChIP-Seq_MCF-7_Human1.35365820
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31801352
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31721809
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26976551
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.26684806
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.26684806
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24457553
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23188408
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20731823
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20604200
51* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19857462
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19568263
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18177006
54KDM2B_26808549_Chip-Seq_K562_Human1.17079646
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15924721
56YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11919800
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.10405657
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.10108448
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09183360
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.07727113
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07061114
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07061114
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06893456
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06626345
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.05877446
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.05091568
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04601100
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03778976
69CTCF_27219007_Chip-Seq_Bcells_Human1.02767550
70CLOCK_20551151_ChIP-Seq_293T_Human0.99151373
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98949433
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97642405
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97596207
74* PIAS1_25552417_ChIP-Seq_VCAP_Human0.97264695
75ISL1_27105846_Chip-Seq_CPCs_Mouse0.96860839
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95434257
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94163126
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93304357
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92481851
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92351609
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92012509
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91562553
83AR_21572438_ChIP-Seq_LNCaP_Human0.91353118
84* SMAD4_21799915_ChIP-Seq_A2780_Human0.91351947
85SOX2_21211035_ChIP-Seq_LN229_Gbm0.91190981
86ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90460833
87AR_19668381_ChIP-Seq_PC3_Human0.87332784
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85046951
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84933714
90* EGR1_19032775_ChIP-ChIP_M12_Human0.83934716
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83439827
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82144237
93PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81736632
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81454472
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81066796
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80930257
97* SMAD3_21741376_ChIP-Seq_HESCs_Human0.80724261
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80457828
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80225513
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79229132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.21815006
2MP0004145_abnormal_muscle_electrophysio3.68458646
3MP0004270_analgesia3.54635337
4MP0000749_muscle_degeneration3.36546530
5MP0004859_abnormal_synaptic_plasticity3.27876374
6MP0003646_muscle_fatigue3.25571486
7MP0003880_abnormal_central_pattern3.06266766
8MP0004036_abnormal_muscle_relaxation2.68086068
9MP0005423_abnormal_somatic_nervous2.59846630
10MP0004510_myositis2.37262514
11MP0000747_muscle_weakness2.23904711
12MP0002106_abnormal_muscle_physiology2.15254090
13MP0004087_abnormal_muscle_fiber2.08236722
14MP0005620_abnormal_muscle_contractility2.05912393
15MP0000759_abnormal_skeletal_muscle2.00022698
16MP0003635_abnormal_synaptic_transmissio1.98662841
17MP0004130_abnormal_muscle_cell1.93259328
18MP0002734_abnormal_mechanical_nocicepti1.91360387
19MP0004084_abnormal_cardiac_muscle1.90148177
20MP0002332_abnormal_exercise_endurance1.88869797
21MP0005369_muscle_phenotype1.87523437
22MP0009379_abnormal_foot_pigmentation1.86169774
23MP0002064_seizures1.83422276
24MP0005670_abnormal_white_adipose1.79559191
25MP0002822_catalepsy1.78743520
26MP0001501_abnormal_sleep_pattern1.75696948
27MP0004215_abnormal_myocardial_fiber1.69119757
28MP0002063_abnormal_learning/memory/cond1.64532170
29MP0003136_yellow_coat_color1.62560235
30MP0000750_abnormal_muscle_regeneration1.58256807
31MP0001486_abnormal_startle_reflex1.56536422
32MP0002972_abnormal_cardiac_muscle1.52546904
33MP0008569_lethality_at_weaning1.50206613
34MP0002272_abnormal_nervous_system1.46827923
35MP0005330_cardiomyopathy1.45992420
36MP0003690_abnormal_glial_cell1.45570331
37MP0003879_abnormal_hair_cell1.41651487
38MP0005275_abnormal_skin_tensile1.38456714
39MP0009745_abnormal_behavioral_response1.38347097
40MP0002269_muscular_atrophy1.36995213
41MP0002735_abnormal_chemical_nociception1.32448891
42MP0003941_abnormal_skin_development1.31208741
43MP0006138_congestive_heart_failure1.30746046
44MP0002572_abnormal_emotion/affect_behav1.30677792
45MP0005666_abnormal_adipose_tissue1.28047660
46MP0002108_abnormal_muscle_morphology1.27787110
47MP0000778_abnormal_nervous_system1.25327322
48MP0004484_altered_response_of1.21918148
49MP0003329_amyloid_beta_deposits1.20467677
50MP0001299_abnormal_eye_distance/1.20426203
51MP0005167_abnormal_blood-brain_barrier1.20210346
52MP0004885_abnormal_endolymph1.17679553
53MP0000733_abnormal_muscle_development1.17437104
54MP0004858_abnormal_nervous_system1.16083515
55MP0000579_abnormal_nail_morphology1.13361569
56MP0002837_dystrophic_cardiac_calcinosis1.11066998
57MP0001970_abnormal_pain_threshold1.08200301
58MP0006276_abnormal_autonomic_nervous1.06901988
59MP0001968_abnormal_touch/_nociception1.05992245
60MP0001440_abnormal_grooming_behavior1.03980739
61MP0003137_abnormal_impulse_conducting1.02917050
62MP0010630_abnormal_cardiac_muscle1.02760041
63MP0009780_abnormal_chondrocyte_physiolo1.01826115
64MP0008004_abnormal_stomach_pH1.01780684
65MP0001984_abnormal_olfaction1.01552647
66MP0002067_abnormal_sensory_capabilities1.00892629
67MP0004043_abnormal_pH_regulation1.00875254
68MP0000920_abnormal_myelination1.00641358
69MP0001188_hyperpigmentation0.99431876
70MP0002653_abnormal_ependyma_morphology0.99363273
71MP0003705_abnormal_hypodermis_morpholog0.99038724
72MP0009046_muscle_twitch0.98739132
73MP0002733_abnormal_thermal_nociception0.98516943
74MP0005171_absent_coat_pigmentation0.97208633
75MP0003633_abnormal_nervous_system0.94791117
76MP0001502_abnormal_circadian_rhythm0.93149449
77MP0001485_abnormal_pinna_reflex0.92678729
78MP0003075_altered_response_to0.91698792
79MP0001544_abnormal_cardiovascular_syste0.91688186
80MP0005385_cardiovascular_system_phenoty0.91688186
81MP0004085_abnormal_heartbeat0.90701206
82MP0002736_abnormal_nociception_after0.89760653
83MP0002066_abnormal_motor_capabilities/c0.87637820
84MP0005375_adipose_tissue_phenotype0.86869895
85MP0005595_abnormal_vascular_smooth0.85327174
86MP0005248_abnormal_Harderian_gland0.84785265
87MP0004233_abnormal_muscle_weight0.83091386
88MP0002638_abnormal_pupillary_reflex0.82846962
89MP0000955_abnormal_spinal_cord0.82064683
90MP0000230_abnormal_systemic_arterial0.80239257
91MP0004811_abnormal_neuron_physiology0.80076177
92MP0005166_decreased_susceptibility_to0.79971541
93MP0002971_abnormal_brown_adipose0.79924409
94MP0005535_abnormal_body_temperature0.78932524
95MP0003634_abnormal_glial_cell0.77984749
96MP0004924_abnormal_behavior0.76807985
97MP0005386_behavior/neurological_phenoty0.76807985
98MP0001664_abnormal_digestion0.76632832
99MP0005409_darkened_coat_color0.76103425
100MP0003303_peritoneal_inflammation0.75602666

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.69147400
2Nemaline bodies (HP:0003798)7.64680301
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.42714125
4Type 1 muscle fiber predominance (HP:0003803)6.36834901
5Exercise-induced myalgia (HP:0003738)5.93256998
6Exercise-induced muscle cramps (HP:0003710)5.59602919
7Muscle hypertrophy of the lower extremities (HP:0008968)4.66591775
8Muscle fiber splitting (HP:0003555)4.28654982
9Hyporeflexia of lower limbs (HP:0002600)4.19911313
10Calf muscle hypertrophy (HP:0008981)4.19045282
11Myopathic facies (HP:0002058)3.97892494
12EMG: myopathic abnormalities (HP:0003458)3.95935927
13Distal arthrogryposis (HP:0005684)3.93174418
14Abnormality of the calf musculature (HP:0001430)3.79949674
15Bundle branch block (HP:0011710)3.78534709
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.75242103
17Sudden death (HP:0001699)3.66990112
18Myoglobinuria (HP:0002913)3.51840491
19Myokymia (HP:0002411)3.46285297
20Abnormality of skeletal muscle fiber size (HP:0012084)3.41665638
21Rhabdomyolysis (HP:0003201)3.39404235
22Rimmed vacuoles (HP:0003805)3.35631297
23Difficulty running (HP:0009046)3.34130177
24Abnormality of the left ventricular outflow tract (HP:0011103)3.32432833
25Subaortic stenosis (HP:0001682)3.32432833
26Neck muscle weakness (HP:0000467)3.27792199
27Focal motor seizures (HP:0011153)3.22935110
28Round ear (HP:0100830)3.12373450
29Distal lower limb muscle weakness (HP:0009053)3.11211464
30Increased variability in muscle fiber diameter (HP:0003557)3.06724326
31Frequent falls (HP:0002359)3.04254279
32Asymmetric septal hypertrophy (HP:0001670)3.03069457
33Myotonia (HP:0002486)2.99541106
34Muscle stiffness (HP:0003552)2.93542805
35Calcaneovalgus deformity (HP:0001848)2.89040889
36Increased connective tissue (HP:0009025)2.79483005
37Action tremor (HP:0002345)2.75267194
38Heart block (HP:0012722)2.71100313
39EMG: neuropathic changes (HP:0003445)2.66392527
40Abnormal atrioventricular conduction (HP:0005150)2.58502481
41Mildly elevated creatine phosphokinase (HP:0008180)2.56321255
42Lower limb amyotrophy (HP:0007210)2.55825516
43Bulbar palsy (HP:0001283)2.54182913
44Abnormality of the foot musculature (HP:0001436)2.48491680
45Ulnar deviation of the wrist (HP:0003049)2.48325793
46Distal lower limb amyotrophy (HP:0008944)2.44403231
47Foot dorsiflexor weakness (HP:0009027)2.43906919
48Areflexia of lower limbs (HP:0002522)2.42626731
49Ventricular tachycardia (HP:0004756)2.42078578
50Deformed tarsal bones (HP:0008119)2.40502904
51Absent phalangeal crease (HP:0006109)2.39590953
52Neurofibrillary tangles (HP:0002185)2.27601598
53Fetal akinesia sequence (HP:0001989)2.27088465
54Syncope (HP:0001279)2.26244853
55Dilated cardiomyopathy (HP:0001644)2.25813713
56Scapular winging (HP:0003691)2.23661522
57Hyperkalemia (HP:0002153)2.20611773
58Atrioventricular block (HP:0001678)2.19963910
59Ankle clonus (HP:0011448)2.18008691
60Focal seizures (HP:0007359)2.16102254
61Generalized muscle weakness (HP:0003324)2.12731558
62Spinal rigidity (HP:0003306)2.07364651
63Obstructive sleep apnea (HP:0002870)2.05368271
64Febrile seizures (HP:0002373)2.02413821
65Steppage gait (HP:0003376)2.02406216
66Ventricular fibrillation (HP:0001663)1.91667253
67Ventricular arrhythmia (HP:0004308)1.89674176
68Generalized tonic-clonic seizures (HP:0002069)1.88739137
69Lipoatrophy (HP:0100578)1.88108761
70Prolonged QT interval (HP:0001657)1.87181977
71Atrial fibrillation (HP:0005110)1.85078598
72Gowers sign (HP:0003391)1.84662267
73Atonic seizures (HP:0010819)1.81647607
74Hip contracture (HP:0003273)1.80453449
75Slender build (HP:0001533)1.80157518
76Supranuclear gaze palsy (HP:0000605)1.78343064
77Primary atrial arrhythmia (HP:0001692)1.75424557
78Nonprogressive disorder (HP:0003680)1.72559488
79Absence seizures (HP:0002121)1.70633800
80Right ventricular cardiomyopathy (HP:0011663)1.70085965
81Abnormal finger flexion creases (HP:0006143)1.70054485
82Rapidly progressive (HP:0003678)1.68296820
83Abnormal EKG (HP:0003115)1.68123432
84Malignant hyperthermia (HP:0002047)1.66761263
85Weak cry (HP:0001612)1.65505767
86Supraventricular tachycardia (HP:0004755)1.63902587
87Cerebral inclusion bodies (HP:0100314)1.62076252
88Proximal amyotrophy (HP:0007126)1.61160467
89Respiratory insufficiency due to muscle weakness (HP:0002747)1.60990789
90Diplopia (HP:0000651)1.60980576
91Abnormality of binocular vision (HP:0011514)1.60980576
92Difficulty climbing stairs (HP:0003551)1.60970003
93Aplasia involving bones of the extremities (HP:0009825)1.60963274
94Aplasia involving bones of the upper limbs (HP:0009823)1.60963274
95Aplasia of the phalanges of the hand (HP:0009802)1.60963274
96Abnormality of the shoulder girdle musculature (HP:0001435)1.60855941
97Waddling gait (HP:0002515)1.59658150
98Urinary bladder sphincter dysfunction (HP:0002839)1.58790255
99Turricephaly (HP:0000262)1.58503548
100Axonal loss (HP:0003447)1.58059624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.43922018
2PHKG13.64683101
3PHKG23.64683101
4EPHA43.63245506
5TTN3.23238728
6MARK13.20327684
7RIPK13.05606533
8DAPK22.17088544
9LATS22.06398657
10CASK2.01891728
11DMPK1.82720805
12PINK11.81506709
13DDR21.79492347
14NTRK21.56617916
15NTRK31.52949990
16PAK61.45972368
17MAPK121.36096195
18PRKD31.31878761
19NTRK11.31043016
20PDGFRA1.27390360
21CAMK11.24115323
22SGK4941.23197591
23SGK2231.23197591
24CAMK2G1.10270154
25TYRO31.08422781
26CAMK1G1.08401553
27SGK21.08057169
28CAMK2B1.06092054
29UHMK11.03414897
30MAP3K71.03293347
31CAMK1D1.01295567
32EEF2K1.00529160
33CCNB10.98696445
34TNIK0.98448739
35MAPKAPK30.97069790
36CDK50.93766387
37MAPK70.92216082
38PKN10.90545637
39MARK20.89653081
40CAMKK10.86781954
41MOS0.86335288
42MAP2K40.85415429
43MINK10.85226212
44CAMK2A0.84859794
45SGK30.84587928
46TESK10.84446617
47CAMK40.84345622
48CDK190.81521427
49GRK50.80695404
50EPHB20.79721586
51CAMK2D0.79493123
52MAPK40.77494911
53DYRK1B0.76753586
54LIMK10.74735169
55TIE10.74552466
56MUSK0.71865258
57ICK0.70172626
58EPHA30.69962413
59MAPK130.69398535
60PIK3CG0.67283402
61PIK3CA0.66761048
62MYLK0.61369162
63PRPF4B0.61336792
64CDK150.60407885
65AKT30.59070716
66DYRK1A0.57444332
67ABL20.57204868
68RPS6KA20.56207029
69GRK70.55785434
70MAPKAPK50.54867285
71SGK10.54667790
72MAPK100.54618138
73CDK180.54269816
74CDK11A0.54169656
75MAP3K60.52151687
76CAMKK20.50611807
77PRKAA20.50146169
78MAP3K90.49948896
79DYRK20.49265188
80MAP3K110.48882777
81ROCK10.47604117
82DAPK30.46970361
83FER0.46927003
84ARAF0.46246170
85CDK140.45500072
86DAPK10.45043990
87AKT20.44682478
88RPS6KA30.42634369
89RET0.42554524
90PRKCH0.40595076
91STK110.39971991
92PRKD10.39624824
93TRIB30.38685186
94PAK30.38193122
95PRKG10.38057135
96ROCK20.37882788
97PRKACA0.34086371
98CSNK1G20.33790202
99RPS6KC10.32952176
100RPS6KL10.32952176

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.52027117
2Cardiac muscle contraction_Homo sapiens_hsa042602.43083383
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.41981782
4Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.20137987
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00318376
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95893900
7Long-term potentiation_Homo sapiens_hsa047201.87704493
8Oxytocin signaling pathway_Homo sapiens_hsa049211.84604551
9Circadian entrainment_Homo sapiens_hsa047131.80712209
10Renin secretion_Homo sapiens_hsa049241.70631077
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70572232
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68374162
13Gastric acid secretion_Homo sapiens_hsa049711.68362577
14Nicotine addiction_Homo sapiens_hsa050331.66190350
15Amphetamine addiction_Homo sapiens_hsa050311.65027746
16Synaptic vesicle cycle_Homo sapiens_hsa047211.63873324
17Calcium signaling pathway_Homo sapiens_hsa040201.62328306
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54854291
19Circadian rhythm_Homo sapiens_hsa047101.52754419
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51390092
21Glutamatergic synapse_Homo sapiens_hsa047241.49396964
22Insulin secretion_Homo sapiens_hsa049111.47717542
23Salivary secretion_Homo sapiens_hsa049701.46980193
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.40321566
25Arginine and proline metabolism_Homo sapiens_hsa003301.37787078
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35946878
27Dopaminergic synapse_Homo sapiens_hsa047281.33196958
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31628430
29GABAergic synapse_Homo sapiens_hsa047271.29766739
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.29324784
31Histidine metabolism_Homo sapiens_hsa003401.24634900
32Cholinergic synapse_Homo sapiens_hsa047251.20050814
33Long-term depression_Homo sapiens_hsa047301.16138866
34GnRH signaling pathway_Homo sapiens_hsa049121.13309335
35Cocaine addiction_Homo sapiens_hsa050301.10735342
36cAMP signaling pathway_Homo sapiens_hsa040241.10662233
37Glucagon signaling pathway_Homo sapiens_hsa049221.10485295
38Gap junction_Homo sapiens_hsa045401.08128095
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07828071
40Tight junction_Homo sapiens_hsa045301.06245662
41Mineral absorption_Homo sapiens_hsa049781.05887656
42Insulin signaling pathway_Homo sapiens_hsa049101.05681013
43Fatty acid degradation_Homo sapiens_hsa000711.05295761
44Pancreatic secretion_Homo sapiens_hsa049721.02499697
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02113821
46Arginine biosynthesis_Homo sapiens_hsa002201.01635765
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99546905
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97931035
49Morphine addiction_Homo sapiens_hsa050320.96384878
50PPAR signaling pathway_Homo sapiens_hsa033200.94700051
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94380253
52Melanogenesis_Homo sapiens_hsa049160.93868148
53Phenylalanine metabolism_Homo sapiens_hsa003600.89724310
54AMPK signaling pathway_Homo sapiens_hsa041520.88589700
55Bile secretion_Homo sapiens_hsa049760.87220394
56Prion diseases_Homo sapiens_hsa050200.86363571
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86063579
58Amoebiasis_Homo sapiens_hsa051460.82680393
59Estrogen signaling pathway_Homo sapiens_hsa049150.82224952
60Axon guidance_Homo sapiens_hsa043600.81454544
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.79129829
62Serotonergic synapse_Homo sapiens_hsa047260.78192571
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.76425763
64Glioma_Homo sapiens_hsa052140.75880294
65Protein digestion and absorption_Homo sapiens_hsa049740.75228976
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73919501
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69447857
68beta-Alanine metabolism_Homo sapiens_hsa004100.68054675
69Renin-angiotensin system_Homo sapiens_hsa046140.65553023
70Alzheimers disease_Homo sapiens_hsa050100.64917725
71Insulin resistance_Homo sapiens_hsa049310.64861713
72VEGF signaling pathway_Homo sapiens_hsa043700.64289688
73Adherens junction_Homo sapiens_hsa045200.62030266
74Fructose and mannose metabolism_Homo sapiens_hsa000510.61258552
75Carbon metabolism_Homo sapiens_hsa012000.59841352
76Fatty acid metabolism_Homo sapiens_hsa012120.57232769
77MAPK signaling pathway_Homo sapiens_hsa040100.56981712
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56001387
79ErbB signaling pathway_Homo sapiens_hsa040120.53191145
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52702728
81Ovarian steroidogenesis_Homo sapiens_hsa049130.51596758
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.51097785
83Pyruvate metabolism_Homo sapiens_hsa006200.49832876
84Tyrosine metabolism_Homo sapiens_hsa003500.48558369
85Rap1 signaling pathway_Homo sapiens_hsa040150.46405704
86Focal adhesion_Homo sapiens_hsa045100.45046161
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44745609
88Ras signaling pathway_Homo sapiens_hsa040140.44209103
89Nitrogen metabolism_Homo sapiens_hsa009100.41926125
90Tryptophan metabolism_Homo sapiens_hsa003800.41570998
91Pertussis_Homo sapiens_hsa051330.39928277
92Propanoate metabolism_Homo sapiens_hsa006400.39819373
93ECM-receptor interaction_Homo sapiens_hsa045120.39670925
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39155859
95Notch signaling pathway_Homo sapiens_hsa043300.38378989
96Pentose phosphate pathway_Homo sapiens_hsa000300.37534397
97Choline metabolism in cancer_Homo sapiens_hsa052310.37271709
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36413395
99Taste transduction_Homo sapiens_hsa047420.35900243
100Starch and sucrose metabolism_Homo sapiens_hsa005000.32888471

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