ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.88667636
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.67357819
3	auditory receptor cell differentiation (GO:0042491)	4.58634762
4	sphingomyelin metabolic process (GO:0006684)	4.34526603
5	fucose catabolic process (GO:0019317)	4.32885730
6	L-fucose metabolic process (GO:0042354)	4.32885730
7	L-fucose catabolic process (GO:0042355)	4.32885730
8	regulation of guanylate cyclase activity (GO:0031282)	4.22539498
9	intestinal epithelial cell development (GO:0060576)	3.84071935
10	intestinal absorption (GO:0050892)	3.81154404
11	epoxygenase P450 pathway (GO:0019373)	3.77473511
12	kidney morphogenesis (GO:0060993)	3.76221951
13	glucuronate metabolic process (GO:0019585)	3.69154737
14	uronic acid metabolic process (GO:0006063)	3.69154737
15	cellular glucuronidation (GO:0052695)	3.61187103
16	vitamin biosynthetic process (GO:0009110)	3.61074148
17	cellular ketone body metabolic process (GO:0046950)	3.54446988
18	positive regulation of guanylate cyclase activity (GO:0031284)	3.49799451
19	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.41906920
20	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.41906920
21	basic amino acid transport (GO:0015802)	3.36367847
22	flavonoid metabolic process (GO:0009812)	3.35073940
23	endocrine pancreas development (GO:0031018)	3.33407053
24	digestion (GO:0007586)	3.30904313
25	desmosome organization (GO:0002934)	3.20615452
26	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.20595556
27	angiotensin maturation (GO:0002003)	3.18635590
28	magnesium ion transport (GO:0015693)	3.16701995
29	hair cell differentiation (GO:0035315)	3.11074145
30	phenylpropanoid metabolic process (GO:0009698)	3.05920730
31	ketone body metabolic process (GO:1902224)	3.03909604
32	drug metabolic process (GO:0017144)	3.02072737
33	exogenous drug catabolic process (GO:0042738)	3.00899695
34	peptide hormone processing (GO:0016486)	2.98329502
35	drug catabolic process (GO:0042737)	2.97803374
36	regulation of acrosome reaction (GO:0060046)	2.93458304
37	urate metabolic process (GO:0046415)	2.93059448
38	transcytosis (GO:0045056)	2.92768152
39	positive regulation of gastrulation (GO:2000543)	2.91235229
40	vitamin transport (GO:0051180)	2.91231441
41	L-alpha-amino acid transmembrane transport (GO:1902475)	2.88119516
42	transepithelial transport (GO:0070633)	2.85384995
43	L-ascorbic acid metabolic process (GO:0019852)	2.85255157
44	excretion (GO:0007588)	2.85067160
45	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.83868729
46	regulation of glucokinase activity (GO:0033131)	2.83368395
47	regulation of hexokinase activity (GO:1903299)	2.83368395
48	cobalamin metabolic process (GO:0009235)	2.82967428
49	sulfur compound transport (GO:0072348)	2.78681949
50	keratinocyte development (GO:0003334)	2.78145922
51	sulfate transmembrane transport (GO:1902358)	2.77523767
52	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.76225581
53	pseudouridine synthesis (GO:0001522)	2.72067038
54	glutathione biosynthetic process (GO:0006750)	2.71460578
55	negative regulation of execution phase of apoptosis (GO:1900118)	2.71321953
56	sulfation (GO:0051923)	2.70451854
57	glutathione derivative biosynthetic process (GO:1901687)	2.69987723
58	glutathione derivative metabolic process (GO:1901685)	2.69987723
59	regulation of bile acid biosynthetic process (GO:0070857)	2.69851429
60	positive regulation of prostaglandin secretion (GO:0032308)	2.69156146
61	phospholipid catabolic process (GO:0009395)	2.68536290
62	regulation of triglyceride catabolic process (GO:0010896)	2.67774093
63	positive regulation of respiratory burst (GO:0060267)	2.67253633
64	regulation of cGMP biosynthetic process (GO:0030826)	2.66369640
65	respiratory chain complex IV assembly (GO:0008535)	2.65583999
66	positive regulation of fatty acid transport (GO:2000193)	2.65570042
67	arginine metabolic process (GO:0006525)	2.65407974
68	multicellular organism reproduction (GO:0032504)	2.64806729
69	response to pheromone (GO:0019236)	2.64714378
70	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.64453359
71	nitric oxide biosynthetic process (GO:0006809)	2.63985925
72	multicellular organismal water homeostasis (GO:0050891)	2.63635735
73	signal transduction involved in regulation of gene expression (GO:0023019)	2.62411288
74	bile acid and bile salt transport (GO:0015721)	2.59855833
75	oligosaccharide biosynthetic process (GO:0009312)	2.59664976
76	nucleotide-sugar biosynthetic process (GO:0009226)	2.59029810
77	behavioral response to nicotine (GO:0035095)	2.58695344
78	somite rostral/caudal axis specification (GO:0032525)	2.56270265
79	vitamin transmembrane transport (GO:0035461)	2.54800931
80	fat-soluble vitamin biosynthetic process (GO:0042362)	2.54790477
81	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.54271516
82	L-phenylalanine catabolic process (GO:0006559)	2.54271516
83	quinone biosynthetic process (GO:1901663)	2.53543390
84	positive regulation of icosanoid secretion (GO:0032305)	2.53174892
85	piRNA metabolic process (GO:0034587)	2.52907934
86	fucosylation (GO:0036065)	2.52327005
87	nonribosomal peptide biosynthetic process (GO:0019184)	2.52233183
88	retinol metabolic process (GO:0042572)	2.51325312
89	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.50941508
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.49402114
91	L-phenylalanine metabolic process (GO:0006558)	2.49402114
92	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.49115295
93	water homeostasis (GO:0030104)	2.46691896
94	organic cation transport (GO:0015695)	2.45773075
95	glandular epithelial cell differentiation (GO:0002067)	2.44734730
96	inner ear receptor cell differentiation (GO:0060113)	2.43968349
97	drug transmembrane transport (GO:0006855)	2.43320400
98	GDP-mannose metabolic process (GO:0019673)	2.42402579
99	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.42322000
100	endocrine process (GO:0050886)	2.42322000

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.61135673
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.13786667
3	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.83985624
4	VDR_22108803_ChIP-Seq_LS180_Human	2.76325533
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48947186
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.32093008
7	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.28765281
8	GATA4_25053715_ChIP-Seq_YYC3_Human	2.03570810
9	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.90475085
10	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.89658349
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87089234
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80156793
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.73755534
14	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.71691082
15	BCAT_22108803_ChIP-Seq_LS180_Human	1.70739581
16	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.68618226
17	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.64265591
18	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.63867462
19	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.63867462
20	CDX2_22108803_ChIP-Seq_LS180_Human	1.60596969
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.59775558
22	* GATA6_25053715_ChIP-Seq_YYC3_Human	1.58337493
23	* SOX2_20726797_ChIP-Seq_SW620_Human	1.54532109
24	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.52853019
25	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.52532599
26	AR_20517297_ChIP-Seq_VCAP_Human	1.50451363
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50154333
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49433743
29	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.47547386
30	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.45244446
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.44865505
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44722276
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43215852
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43078880
35	P300_19829295_ChIP-Seq_ESCs_Human	1.40118978
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38604599
37	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.38454185
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.36794490
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36024173
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.35941645
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35216584
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34688090
43	HOXB7_26014856_ChIP-Seq_BT474_Human	1.33901622
44	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.33559254
45	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33362399
46	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.32272422
47	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.32146465
48	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.29611048
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29288308
50	NCOR_22424771_ChIP-Seq_293T_Human	1.26621921
51	AR_25329375_ChIP-Seq_VCAP_Human	1.25878301
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25749290
53	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.25107881
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25078126
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.24374379
56	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.22857368
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18019672
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.17621800
59	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.17542580
60	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14234897
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.10177292
62	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.09015852
63	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.08472352
64	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07912342
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07482493
66	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.06351149
67	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.05832763
68	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.05536780
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05198155
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05198155
71	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.04672729
72	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04491684
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04220312
74	ERA_21632823_ChIP-Seq_H3396_Human	1.03891914
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03352483
76	STAT3_23295773_ChIP-Seq_U87_Human	1.01823240
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01537330
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01138682
79	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00146577
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99742784
81	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99280616
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98858112
83	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.98819708
84	* FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98819201
85	* HNF4A_19822575_ChIP-Seq_HepG2_Human	0.98246638
86	TCF4_23295773_ChIP-Seq_U87_Human	0.97912430
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97695703
88	CBP_20019798_ChIP-Seq_JUKART_Human	0.97695703
89	EWS_26573619_Chip-Seq_HEK293_Human	0.97162649
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96689606
91	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.96651945
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.96380214
93	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.96358349
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94234682
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93776445
96	* PHF8_20622853_ChIP-Seq_HELA_Human	0.92706063
97	FUS_26573619_Chip-Seq_HEK293_Human	0.92705228
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92660776
99	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.92167648
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91840476

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	3.82509867
2	MP0005360_urolithiasis	3.64284544
3	MP0003195_calcinosis	3.60749234
4	MP0004019_abnormal_vitamin_homeostasis	3.46035729
5	MP0002139_abnormal_hepatobiliary_system	3.45746329
6	MP0001666_abnormal_nutrient_absorption	3.23096739
7	MP0005085_abnormal_gallbladder_physiolo	2.94211617
8	MP0003718_maternal_effect	2.72239526
9	MP0002876_abnormal_thyroid_physiology	2.65391178
10	MP0005365_abnormal_bile_salt	2.52958885
11	MP0004043_abnormal_pH_regulation	2.36775090
12	MP0004147_increased_porphyrin_level	2.27925704
13	MP0004264_abnormal_extraembryonic_tissu	2.21265690
14	MP0008875_abnormal_xenobiotic_pharmacok	2.12319216
15	MP0005645_abnormal_hypothalamus_physiol	2.09740632
16	MP0002909_abnormal_adrenal_gland	2.08101413
17	MP0001765_abnormal_ion_homeostasis	2.03422523
18	MP0005332_abnormal_amino_acid	2.02083466
19	MP0002837_dystrophic_cardiac_calcinosis	2.01084109
20	MP0005636_abnormal_mineral_homeostasis	1.92917272
21	MP0010329_abnormal_lipoprotein_level	1.87389361
22	MP0009780_abnormal_chondrocyte_physiolo	1.87223334
23	MP0005379_endocrine/exocrine_gland_phen	1.68846432
24	MP0002254_reproductive_system_inflammat	1.68319398
25	MP0002796_impaired_skin_barrier	1.66199833
26	MP0001664_abnormal_digestion	1.65699808
27	MP0010678_abnormal_skin_adnexa	1.62166856
28	MP0000566_synostosis	1.59731218
29	MP0001501_abnormal_sleep_pattern	1.59390387
30	MP0009379_abnormal_foot_pigmentation	1.59327330
31	MP0009643_abnormal_urine_homeostasis	1.58764858
32	MP0000427_abnormal_hair_cycle	1.57419944
33	MP0001756_abnormal_urination	1.56236888
34	MP0002138_abnormal_hepatobiliary_system	1.54925282
35	MP0001944_abnormal_pancreas_morphology	1.54222862
36	MP0008872_abnormal_physiological_respon	1.52143787
37	MP0008877_abnormal_DNA_methylation	1.47130424
38	MP0003183_abnormal_peptide_metabolism	1.46873708
39	MP0001986_abnormal_taste_sensitivity	1.41409698
40	MP0001188_hyperpigmentation	1.38902500
41	MP0005395_other_phenotype	1.37143649
42	MP0003879_abnormal_hair_cell	1.33786426
43	MP0003283_abnormal_digestive_organ	1.32533622
44	MP0005551_abnormal_eye_electrophysiolog	1.31916584
45	MP0002163_abnormal_gland_morphology	1.29156949
46	MP0001485_abnormal_pinna_reflex	1.28196790
47	MP0000383_abnormal_hair_follicle	1.24835038
48	MP0002693_abnormal_pancreas_physiology	1.23467991
49	MP0005646_abnormal_pituitary_gland	1.23356088
50	MP0002938_white_spotting	1.22565801
51	MP0003787_abnormal_imprinting	1.20781777
52	MP0004133_heterotaxia	1.20180853
53	MP0010352_gastrointestinal_tract_polyps	1.19264399
54	MP0004885_abnormal_endolymph	1.19098545
55	MP0002277_abnormal_respiratory_mucosa	1.16786856
56	MP0002098_abnormal_vibrissa_morphology	1.16290790
57	MP0003252_abnormal_bile_duct	1.15378163
58	MP0001764_abnormal_homeostasis	1.12711870
59	MP0000538_abnormal_urinary_bladder	1.09048801
60	MP0003866_abnormal_defecation	1.07914558
61	MP0009840_abnormal_foam_cell	1.06880636
62	MP0000470_abnormal_stomach_morphology	1.06877544
63	MP0002160_abnormal_reproductive_system	1.06513293
64	MP0006072_abnormal_retinal_apoptosis	1.06335584
65	MP0000631_abnormal_neuroendocrine_gland	1.05854185
66	MP0001873_stomach_inflammation	1.05263563
67	MP0000678_abnormal_parathyroid_gland	1.04773726
68	MP0003890_abnormal_embryonic-extraembry	1.04343782
69	MP0002118_abnormal_lipid_homeostasis	1.04321109
70	MP0003011_delayed_dark_adaptation	1.03481206
71	MP0003953_abnormal_hormone_level	1.02284154
72	MP0005389_reproductive_system_phenotype	0.99005587
73	MP0002078_abnormal_glucose_homeostasis	0.97536436
74	MP0005377_hearing/vestibular/ear_phenot	0.95256525
75	MP0003878_abnormal_ear_physiology	0.95256525
76	MP0004782_abnormal_surfactant_physiolog	0.94335235
77	MP0010386_abnormal_urinary_bladder	0.93731061
78	MP0006292_abnormal_olfactory_placode	0.90525026
79	MP0000569_abnormal_digit_pigmentation	0.89996760
80	MP0002136_abnormal_kidney_physiology	0.89635877
81	MP0005220_abnormal_exocrine_pancreas	0.87777896
82	MP0005174_abnormal_tail_pigmentation	0.87261033
83	MP0005448_abnormal_energy_balance	0.86569194
84	MP0001881_abnormal_mammary_gland	0.86299838
85	MP0005501_abnormal_skin_physiology	0.84949300
86	MP0001919_abnormal_reproductive_system	0.83636204
87	MP0005084_abnormal_gallbladder_morpholo	0.83439863
88	MP0000230_abnormal_systemic_arterial	0.81275278
89	MP0002102_abnormal_ear_morphology	0.80803727
90	MP0003938_abnormal_ear_development	0.80017341
91	MP0000516_abnormal_urinary_system	0.79888731
92	MP0005367_renal/urinary_system_phenotyp	0.79888731
93	MP0000477_abnormal_intestine_morphology	0.75094052
94	MP0002272_abnormal_nervous_system	0.74214698
95	MP0008775_abnormal_heart_ventricle	0.74061610
96	MP0005408_hypopigmentation	0.72990421
97	MP0003119_abnormal_digestive_system	0.72686358
98	MP0000462_abnormal_digestive_system	0.71027625
99	MP0005410_abnormal_fertilization	0.70978226
100	MP0002736_abnormal_nociception_after	0.70289065

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperactive renin-angiotensin system (HP:0000841)	4.44726184
2	Abnormality of renin-angiotensin system (HP:0000847)	3.97506406
3	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.84469508
4	Decreased circulating renin level (HP:0003351)	3.76251609
5	Abnormality of vitamin B metabolism (HP:0004340)	3.75511039
6	Hypomagnesemia (HP:0002917)	3.28241559
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.24294531
8	Hypothermia (HP:0002045)	3.23538024
9	Abnormality of vitamin metabolism (HP:0100508)	3.15634215
10	Abnormality of magnesium homeostasis (HP:0004921)	3.11351541
11	Proximal tubulopathy (HP:0000114)	2.99081062
12	Congenital sensorineural hearing impairment (HP:0008527)	2.97928665
13	Polydipsia (HP:0001959)	2.93880393
14	Abnormal drinking behavior (HP:0030082)	2.93880393
15	Hyperaldosteronism (HP:0000859)	2.82276114
16	Tubular atrophy (HP:0000092)	2.81116673
17	Hyperglycinuria (HP:0003108)	2.80674042
18	Metabolic alkalosis (HP:0200114)	2.77342893
19	Abnormality of proline metabolism (HP:0010907)	2.76459461
20	Hydroxyprolinuria (HP:0003080)	2.76459461
21	Amelogenesis imperfecta (HP:0000705)	2.74512188
22	Abnormality of the renal cortex (HP:0011035)	2.73706932
23	Glycosuria (HP:0003076)	2.70055902
24	Abnormality of urine glucose concentration (HP:0011016)	2.70055902
25	Pancreatic cysts (HP:0001737)	2.65147571
26	Chronic bronchitis (HP:0004469)	2.62061119
27	Hypoglycemic coma (HP:0001325)	2.61995954
28	Malnutrition (HP:0004395)	2.60868017
29	Tetany (HP:0001281)	2.57199255
30	Hyperphosphatemia (HP:0002905)	2.57044273
31	Ketoacidosis (HP:0001993)	2.56065349
32	Abnormality of serine family amino acid metabolism (HP:0010894)	2.52285030
33	Abnormality of glycine metabolism (HP:0010895)	2.52285030
34	Late onset (HP:0003584)	2.49100796
35	Abnormality of chloride homeostasis (HP:0011422)	2.47157028
36	Abnormality of renal excretion (HP:0011036)	2.44907388
37	Ketosis (HP:0001946)	2.41428337
38	Fat malabsorption (HP:0002630)	2.37407543
39	Pendular nystagmus (HP:0012043)	2.35966937
40	Increased circulating renin level (HP:0000848)	2.29116536
41	Alkalosis (HP:0001948)	2.26122546
42	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.25298985
43	Hyperinsulinemic hypoglycemia (HP:0000825)	2.21839331
44	Polyuria (HP:0000103)	2.21412253
45	Large for gestational age (HP:0001520)	2.18380871
46	Pancreatic fibrosis (HP:0100732)	2.16731049
47	Hyperphosphaturia (HP:0003109)	2.15594173
48	Congenital stationary night blindness (HP:0007642)	2.14381765
49	Megaloblastic anemia (HP:0001889)	2.12149757
50	Methylmalonic acidemia (HP:0002912)	2.12073140
51	Abnormal urine output (HP:0012590)	2.11605747
52	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.10461978
53	Metabolic acidosis (HP:0001942)	2.09812056
54	Molar tooth sign on MRI (HP:0002419)	2.09747120
55	Abnormality of midbrain morphology (HP:0002418)	2.09747120
56	Abnormal biliary tract morphology (HP:0012440)	2.09260934
57	Vascular calcification (HP:0004934)	2.08155954
58	Renal salt wasting (HP:0000127)	2.07761388
59	Pigmentary retinal degeneration (HP:0001146)	2.07561934
60	Methylmalonic aciduria (HP:0012120)	2.07123268
61	Hypoplasia of the pons (HP:0012110)	2.04403251
62	Hyperuricemia (HP:0002149)	2.01295535
63	Increased purine levels (HP:0004368)	2.01295535
64	Hypobetalipoproteinemia (HP:0003563)	1.98658238
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97810583
66	Intrahepatic cholestasis (HP:0001406)	1.97718041
67	Lethargy (HP:0001254)	1.97419565
68	Confusion (HP:0001289)	1.96713248
69	Abnormality of the pons (HP:0007361)	1.96527906
70	Nephronophthisis (HP:0000090)	1.96333759
71	Abnormal urine phosphate concentration (HP:0012599)	1.95279649
72	Prolonged partial thromboplastin time (HP:0003645)	1.94987406
73	Hypokalemia (HP:0002900)	1.94983853
74	Tongue fasciculations (HP:0001308)	1.91770303
75	Chronic diarrhea (HP:0002028)	1.89284468
76	Hyperglycemia (HP:0003074)	1.88729401
77	Hyperventilation (HP:0002883)	1.88711855
78	Abnormality of the renal medulla (HP:0100957)	1.88418972
79	Steatorrhea (HP:0002570)	1.87411276
80	True hermaphroditism (HP:0010459)	1.85764538
81	Right ventricular cardiomyopathy (HP:0011663)	1.85467368
82	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.84675059
83	Hypoplasia of the fovea (HP:0007750)	1.84675059
84	Hypoglycemic seizures (HP:0002173)	1.84305985
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83358070
86	Enlarged penis (HP:0000040)	1.81258585
87	Hepatic necrosis (HP:0002605)	1.81061252
88	Abnormality of potassium homeostasis (HP:0011042)	1.80971523
89	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.79524065
90	Azoospermia (HP:0000027)	1.79354495
91	Abnormality of the labia minora (HP:0012880)	1.76950121
92	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.75630395
93	Dicarboxylic aciduria (HP:0003215)	1.75630395
94	Abolished electroretinogram (ERG) (HP:0000550)	1.75360037
95	Widely patent fontanelles and sutures (HP:0004492)	1.75218078
96	Goiter (HP:0000853)	1.74598091
97	Furrowed tongue (HP:0000221)	1.74487708
98	Chorioretinal atrophy (HP:0000533)	1.73836462
99	Attenuation of retinal blood vessels (HP:0007843)	1.73377348
100	Pili torti (HP:0003777)	1.72868146

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.22668770
2	ACVR1B	3.84311223
3	MST4	3.66738376
4	EPHA2	3.53149279
5	GRK1	3.35569929
6	STK39	2.78379459
7	STK24	2.32146168
8	NUAK1	2.27439064
9	PINK1	2.27276039
10	OXSR1	2.25327610
11	FER	2.16654873
12	MAP4K2	2.06662087
13	ADRBK2	2.04412106
14	PIK3CA	1.93744876
15	INSRR	1.86633434
16	WNK4	1.73491812
17	MST1R	1.73450675
18	FGFR2	1.72719553
19	WNK3	1.71558404
20	MAP3K12	1.70935525
21	NME1	1.68059363
22	LMTK2	1.66030670
23	MAPKAPK3	1.65373431
24	SIK3	1.63442734
25	ZAK	1.62564221
26	STK3	1.60760816
27	VRK2	1.48223838
28	TLK1	1.47977211
29	PRKCI	1.44724295
30	TNIK	1.42922064
31	BMPR1B	1.40037935
32	TAOK3	1.39409883
33	STK38L	1.31823665
34	PRKCE	1.23641286
35	PHKG1	1.20798097
36	PHKG2	1.20798097
37	MAP2K6	1.20447102
38	MAP3K9	1.18636668
39	MET	1.10019504
40	TRIM28	1.07887137
41	PAK3	1.07632152
42	CASK	1.07403246
43	MUSK	1.04446133
44	MAP3K2	0.98417671
45	MAPK15	0.97783821
46	TTK	0.95969252
47	PRKG2	0.90106347
48	LATS1	0.88788241
49	EPHA3	0.87535107
50	MAP2K2	0.85979036
51	PRKAA2	0.84080953
52	BRSK2	0.77939946
53	ERN1	0.76353019
54	NLK	0.69593197
55	IRAK1	0.65307627
56	CHUK	0.62393086
57	CSNK1A1	0.62368353
58	CAMK2D	0.62302139
59	PRKCG	0.61306065
60	VRK1	0.61230321
61	RPS6KB2	0.61106915
62	EIF2AK3	0.60300080
63	TIE1	0.57959956
64	MKNK2	0.52409913
65	MAPK13	0.49639416
66	IKBKB	0.48751687
67	PRKCZ	0.47726132
68	DAPK2	0.47535478
69	SIK1	0.46079474
70	PRKCA	0.45542486
71	ERBB2	0.43837501
72	MAPKAPK5	0.43214743
73	DYRK2	0.42903272
74	PASK	0.42529086
75	TAF1	0.42105369
76	PRKCQ	0.41780530
77	PRKAA1	0.39975690
78	TAOK1	0.39844578
79	CSNK1G1	0.39578880
80	ERBB3	0.38239771
81	CSNK1E	0.34943855
82	CAMK2A	0.34530684
83	NEK6	0.32957516
84	MAP2K1	0.32695007
85	AKT3	0.32349808
86	PRKD3	0.31990490
87	IRAK4	0.31510385
88	PRKACA	0.29872027
89	PLK3	0.29199112
90	NTRK3	0.28159950
91	PTK2	0.27270936
92	CSNK1G2	0.25481281
93	PTK6	0.24794744
94	STK11	0.24114806
95	STK4	0.23109509
96	ADRBK1	0.22314942
97	STK38	0.21822210
98	CSNK1G3	0.21813445
99	IGF1R	0.20879983
100	PRKACB	0.20267776

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.10430897
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.02390863
3	Caffeine metabolism_Homo sapiens_hsa00232	2.72873545
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.65920260
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.65718747
6	Fat digestion and absorption_Homo sapiens_hsa04975	2.58311136
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.56367046
8	Sulfur metabolism_Homo sapiens_hsa00920	2.38141523
9	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.27968132
10	Histidine metabolism_Homo sapiens_hsa00340	2.26415403
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19014987
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07098616
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96254503
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.95052207
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.94467995
16	Retinol metabolism_Homo sapiens_hsa00830	1.94274955
17	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.93007500
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.90303329
19	Mineral absorption_Homo sapiens_hsa04978	1.88679380
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84714203
21	Butanoate metabolism_Homo sapiens_hsa00650	1.81103346
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.79794363
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.78604126
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.71453828
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64522429
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.61702896
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.54608322
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.51818990
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49334467
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.42564246
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.41802374
32	Renin-angiotensin system_Homo sapiens_hsa04614	1.40595088
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36426579
34	Arginine biosynthesis_Homo sapiens_hsa00220	1.32700574
35	Fatty acid degradation_Homo sapiens_hsa00071	1.32454115
36	Peroxisome_Homo sapiens_hsa04146	1.30102708
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.28989329
38	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25580866
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21140443
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.19294055
41	Phototransduction_Homo sapiens_hsa04744	1.18964503
42	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16634581
43	Propanoate metabolism_Homo sapiens_hsa00640	1.15750298
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.15628012
45	Glutathione metabolism_Homo sapiens_hsa00480	1.09514191
46	Sulfur relay system_Homo sapiens_hsa04122	1.07673247
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05742971
48	Bile secretion_Homo sapiens_hsa04976	1.03551568
49	Folate biosynthesis_Homo sapiens_hsa00790	0.99581140
50	Insulin secretion_Homo sapiens_hsa04911	0.98019310
51	Protein export_Homo sapiens_hsa03060	0.94395333
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91776778
53	Protein digestion and absorption_Homo sapiens_hsa04974	0.91572370
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91531395
55	Fatty acid elongation_Homo sapiens_hsa00062	0.79764503
56	ABC transporters_Homo sapiens_hsa02010	0.79066816
57	PPAR signaling pathway_Homo sapiens_hsa03320	0.78057025
58	Pancreatic secretion_Homo sapiens_hsa04972	0.77763690
59	Metabolic pathways_Homo sapiens_hsa01100	0.77087322
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76679869
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76379992
62	Galactose metabolism_Homo sapiens_hsa00052	0.76021614
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.74946133
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.73014699
65	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71535353
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69085054
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68636000
68	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.66696582
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65118357
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.63888576
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58759367
72	Circadian rhythm_Homo sapiens_hsa04710	0.58104585
73	Tight junction_Homo sapiens_hsa04530	0.57944997
74	Parkinsons disease_Homo sapiens_hsa05012	0.57758464
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55878466
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54517650
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54364046
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53317506
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52774337
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51033645
81	Taste transduction_Homo sapiens_hsa04742	0.50277868
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47797096
83	Serotonergic synapse_Homo sapiens_hsa04726	0.46513336
84	Huntingtons disease_Homo sapiens_hsa05016	0.43114684
85	Basal transcription factors_Homo sapiens_hsa03022	0.42853963
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38696497
87	Alzheimers disease_Homo sapiens_hsa05010	0.38445547
88	One carbon pool by folate_Homo sapiens_hsa00670	0.33559962
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.32929697
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31701527
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.30362697
92	Cocaine addiction_Homo sapiens_hsa05030	0.29792063
93	Amphetamine addiction_Homo sapiens_hsa05031	0.23726301
94	RNA polymerase_Homo sapiens_hsa03020	0.23406196
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.21598177
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.21510243
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.20305967
98	Homologous recombination_Homo sapiens_hsa03440	0.18920187
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.18885769
100	Salivary secretion_Homo sapiens_hsa04970	0.17841522

C1ORF210

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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