Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit biogenesis (GO:0042274) | 6.30436763 |
2 | viral transcription (GO:0019083) | 6.21848562 |
3 | translational termination (GO:0006415) | 5.98352401 |
4 | maturation of SSU-rRNA (GO:0030490) | 5.76087875 |
5 | ribosomal small subunit assembly (GO:0000028) | 5.36628428 |
6 | translational elongation (GO:0006414) | 5.14679973 |
7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.13927923 |
8 | cotranslational protein targeting to membrane (GO:0006613) | 5.05855310 |
9 | protein targeting to ER (GO:0045047) | 5.00062981 |
10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.79710405 |
11 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.75016540 |
12 | viral life cycle (GO:0019058) | 4.70326623 |
13 | protein localization to endoplasmic reticulum (GO:0070972) | 4.68200894 |
14 | cellular protein complex disassembly (GO:0043624) | 4.66065071 |
15 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.58483684 |
16 | regulation of mitochondrial translation (GO:0070129) | 4.56159271 |
17 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.55977602 |
18 | chaperone-mediated protein transport (GO:0072321) | 4.48339023 |
19 | protein complex biogenesis (GO:0070271) | 4.40245072 |
20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.33039630 |
21 | ATP synthesis coupled proton transport (GO:0015986) | 4.33039630 |
22 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.32076770 |
23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.29233527 |
24 | translational initiation (GO:0006413) | 4.27501583 |
25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.24050841 |
26 | NADH dehydrogenase complex assembly (GO:0010257) | 4.24050841 |
27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.24050841 |
28 | protein complex disassembly (GO:0043241) | 4.18329397 |
29 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.09911714 |
30 | macromolecular complex disassembly (GO:0032984) | 3.96496387 |
31 | respiratory electron transport chain (GO:0022904) | 3.95056398 |
32 | electron transport chain (GO:0022900) | 3.89901327 |
33 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.84825377 |
34 | DNA replication checkpoint (GO:0000076) | 3.81551182 |
35 | translation (GO:0006412) | 3.81426731 |
36 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.76846797 |
37 | cellular component biogenesis (GO:0044085) | 3.75523882 |
38 | ribosomal large subunit biogenesis (GO:0042273) | 3.74589556 |
39 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.72072244 |
40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.61862220 |
41 | termination of RNA polymerase III transcription (GO:0006386) | 3.61862220 |
42 | chromatin remodeling at centromere (GO:0031055) | 3.57682183 |
43 | DNA strand elongation (GO:0022616) | 3.53535609 |
44 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.52458167 |
45 | protein targeting to mitochondrion (GO:0006626) | 3.47964462 |
46 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.47562515 |
47 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.44511969 |
48 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.41122095 |
49 | establishment of protein localization to mitochondrion (GO:0072655) | 3.38811936 |
50 | rRNA processing (GO:0006364) | 3.37058401 |
51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.36953987 |
52 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.36953987 |
53 | DNA damage response, detection of DNA damage (GO:0042769) | 3.36657276 |
54 | protein-cofactor linkage (GO:0018065) | 3.35097952 |
55 | pseudouridine synthesis (GO:0001522) | 3.33998059 |
56 | protein targeting to membrane (GO:0006612) | 3.33080129 |
57 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.32207847 |
58 | mRNA catabolic process (GO:0006402) | 3.31580911 |
59 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31341455 |
60 | rRNA metabolic process (GO:0016072) | 3.26376389 |
61 | protein localization to mitochondrion (GO:0070585) | 3.24755434 |
62 | CTP biosynthetic process (GO:0006241) | 3.24064093 |
63 | CTP metabolic process (GO:0046036) | 3.24064093 |
64 | kinetochore assembly (GO:0051382) | 3.23178171 |
65 | spliceosomal snRNP assembly (GO:0000387) | 3.23113441 |
66 | CENP-A containing nucleosome assembly (GO:0034080) | 3.21415886 |
67 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.20972722 |
68 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.20824643 |
69 | cytochrome complex assembly (GO:0017004) | 3.19705279 |
70 | kinetochore organization (GO:0051383) | 3.19274510 |
71 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.19096842 |
72 | replication fork processing (GO:0031297) | 3.18945088 |
73 | protein neddylation (GO:0045116) | 3.17446889 |
74 | telomere maintenance via recombination (GO:0000722) | 3.14466170 |
75 | heterochromatin organization (GO:0070828) | 3.11385968 |
76 | base-excision repair, AP site formation (GO:0006285) | 3.11227132 |
77 | GTP biosynthetic process (GO:0006183) | 3.10752135 |
78 | RNA catabolic process (GO:0006401) | 3.10501451 |
79 | DNA replication initiation (GO:0006270) | 3.06285774 |
80 | peptidyl-histidine modification (GO:0018202) | 3.05538745 |
81 | respiratory chain complex IV assembly (GO:0008535) | 3.05405084 |
82 | UTP biosynthetic process (GO:0006228) | 3.04898400 |
83 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 3.00313549 |
84 | ribosome biogenesis (GO:0042254) | 2.99245716 |
85 | behavioral response to nicotine (GO:0035095) | 2.96778509 |
86 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.94749811 |
87 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.94556670 |
88 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 2.94184762 |
89 | proteasome assembly (GO:0043248) | 2.93339998 |
90 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.91785992 |
91 | protein K6-linked ubiquitination (GO:0085020) | 2.91248571 |
92 | rRNA modification (GO:0000154) | 2.90166589 |
93 | mitotic recombination (GO:0006312) | 2.89882035 |
94 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.89495472 |
95 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.87853904 |
96 | intracellular protein transmembrane import (GO:0044743) | 2.85381648 |
97 | tRNA processing (GO:0008033) | 2.80864951 |
98 | pyrimidine nucleotide biosynthetic process (GO:0006221) | 2.79785200 |
99 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.79583409 |
100 | DNA deamination (GO:0045006) | 2.78342133 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.76108684 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.81664323 |
3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.66962041 |
4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.60951207 |
5 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.53072718 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.52061439 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.24298720 |
8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.23571665 |
9 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.22063389 |
10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.91853829 |
11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.89825247 |
12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.85799143 |
13 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.79247414 |
14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.78891191 |
15 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.63135004 |
16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.61872593 |
17 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.58701946 |
18 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.50748746 |
19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.48251032 |
20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.46887385 |
21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44823494 |
22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.37411919 |
23 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.29853350 |
24 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.29791463 |
25 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.27689677 |
26 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.21427275 |
27 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.07775057 |
28 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.05091750 |
29 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.02396545 |
30 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.01092782 |
31 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.00403319 |
32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.99203805 |
33 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85887557 |
34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.84695798 |
35 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.83984185 |
36 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.76042689 |
37 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.74821646 |
38 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.74257718 |
39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.68532580 |
40 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.67649335 |
41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65156385 |
42 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.64992655 |
43 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.59452590 |
44 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.58570826 |
45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.52441971 |
46 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51886981 |
47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40716528 |
48 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.38476708 |
49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37868980 |
50 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.34836149 |
51 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34732918 |
52 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.33395978 |
53 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.33352035 |
54 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.31952058 |
55 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.31739958 |
56 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.30983533 |
57 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.30900238 |
58 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.30453153 |
59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.29988337 |
60 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.29139596 |
61 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.29131310 |
62 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.27332330 |
63 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.24359073 |
64 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.23408777 |
65 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.23405916 |
66 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.21267222 |
67 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.20534589 |
68 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.19355132 |
69 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19150212 |
70 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.17193365 |
71 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.16406932 |
72 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.14345819 |
73 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.12725676 |
74 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.12482852 |
75 | P68_20966046_ChIP-Seq_HELA_Human | 1.12119097 |
76 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09416103 |
77 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.07828300 |
78 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05936696 |
79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.05467199 |
80 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.01965743 |
81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.00109891 |
82 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.99703988 |
83 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99061152 |
84 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.99033548 |
85 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.95983094 |
86 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.95453230 |
87 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.94525943 |
88 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.94168085 |
89 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91798975 |
90 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.89550908 |
91 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.83992729 |
92 | ERA_21632823_ChIP-Seq_H3396_Human | 0.82712616 |
93 | * IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81275616 |
94 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.80741229 |
95 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.79470479 |
96 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.78024093 |
97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.77826102 |
98 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.76674902 |
99 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.76601962 |
100 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.76289238 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0006292_abnormal_olfactory_placode | 4.37882693 |
2 | MP0009379_abnormal_foot_pigmentation | 3.89676861 |
3 | MP0003693_abnormal_embryo_hatching | 3.16782764 |
4 | MP0010094_abnormal_chromosome_stability | 2.89727436 |
5 | MP0010030_abnormal_orbit_morphology | 2.88009128 |
6 | MP0008058_abnormal_DNA_repair | 2.70561099 |
7 | MP0003111_abnormal_nucleus_morphology | 2.64981603 |
8 | MP0000566_synostosis | 2.55948154 |
9 | MP0003136_yellow_coat_color | 2.39415026 |
10 | MP0002653_abnormal_ependyma_morphology | 2.31230403 |
11 | MP0003077_abnormal_cell_cycle | 2.12033636 |
12 | MP0008789_abnormal_olfactory_epithelium | 2.07787272 |
13 | MP0003123_paternal_imprinting | 2.04319906 |
14 | MP0002938_white_spotting | 1.97520060 |
15 | MP0003878_abnormal_ear_physiology | 1.95278311 |
16 | MP0005377_hearing/vestibular/ear_phenot | 1.95278311 |
17 | MP0000049_abnormal_middle_ear | 1.95179087 |
18 | MP0003786_premature_aging | 1.86840482 |
19 | MP0002249_abnormal_larynx_morphology | 1.82999820 |
20 | MP0001293_anophthalmia | 1.79046161 |
21 | MP0001346_abnormal_lacrimal_gland | 1.75553256 |
22 | MP0008932_abnormal_embryonic_tissue | 1.75461977 |
23 | MP0002234_abnormal_pharynx_morphology | 1.75276063 |
24 | MP0008995_early_reproductive_senescence | 1.75130958 |
25 | MP0005394_taste/olfaction_phenotype | 1.74787652 |
26 | MP0005499_abnormal_olfactory_system | 1.74787652 |
27 | MP0004957_abnormal_blastocyst_morpholog | 1.67222689 |
28 | MP0008877_abnormal_DNA_methylation | 1.65414941 |
29 | MP0003718_maternal_effect | 1.62959519 |
30 | MP0002160_abnormal_reproductive_system | 1.47991492 |
31 | MP0006036_abnormal_mitochondrial_physio | 1.47718606 |
32 | MP0002638_abnormal_pupillary_reflex | 1.47223161 |
33 | MP0003121_genomic_imprinting | 1.46437794 |
34 | MP0002210_abnormal_sex_determination | 1.46249696 |
35 | MP0000631_abnormal_neuroendocrine_gland | 1.43644758 |
36 | MP0003806_abnormal_nucleotide_metabolis | 1.42479669 |
37 | MP0003186_abnormal_redox_activity | 1.37836436 |
38 | MP0002102_abnormal_ear_morphology | 1.35719115 |
39 | MP0006035_abnormal_mitochondrial_morpho | 1.34789433 |
40 | MP0003938_abnormal_ear_development | 1.33280626 |
41 | MP0001529_abnormal_vocalization | 1.32612288 |
42 | MP0008057_abnormal_DNA_replication | 1.28584983 |
43 | MP0001905_abnormal_dopamine_level | 1.24217753 |
44 | MP0002277_abnormal_respiratory_mucosa | 1.23812637 |
45 | MP0002736_abnormal_nociception_after | 1.23641323 |
46 | MP0004133_heterotaxia | 1.20165857 |
47 | MP0006072_abnormal_retinal_apoptosis | 1.18888578 |
48 | MP0003011_delayed_dark_adaptation | 1.18605979 |
49 | MP0008007_abnormal_cellular_replicative | 1.16834823 |
50 | MP0001188_hyperpigmentation | 1.15819032 |
51 | MP0003937_abnormal_limbs/digits/tail_de | 1.14118397 |
52 | MP0001986_abnormal_taste_sensitivity | 1.13394342 |
53 | MP0001929_abnormal_gametogenesis | 1.09190212 |
54 | MP0001485_abnormal_pinna_reflex | 1.09145635 |
55 | MP0002163_abnormal_gland_morphology | 1.08863445 |
56 | MP0001968_abnormal_touch/_nociception | 1.08504788 |
57 | MP0001145_abnormal_male_reproductive | 1.08377949 |
58 | MP0004142_abnormal_muscle_tone | 1.07823158 |
59 | MP0003880_abnormal_central_pattern | 1.04643501 |
60 | MP0005389_reproductive_system_phenotype | 1.04267758 |
61 | MP0003698_abnormal_male_reproductive | 1.03819381 |
62 | MP0000653_abnormal_sex_gland | 1.01699349 |
63 | MP0003787_abnormal_imprinting | 1.00985113 |
64 | MP0003315_abnormal_perineum_morphology | 0.99621761 |
65 | MP0000026_abnormal_inner_ear | 0.99589700 |
66 | MP0001286_abnormal_eye_development | 0.98983867 |
67 | MP0000372_irregular_coat_pigmentation | 0.97816676 |
68 | MP0005646_abnormal_pituitary_gland | 0.95708946 |
69 | MP0009697_abnormal_copulation | 0.93713705 |
70 | MP0001919_abnormal_reproductive_system | 0.93389287 |
71 | MP0001764_abnormal_homeostasis | 0.89985842 |
72 | MP0002822_catalepsy | 0.89966512 |
73 | MP0006276_abnormal_autonomic_nervous | 0.89304110 |
74 | MP0000678_abnormal_parathyroid_gland | 0.87575690 |
75 | MP0002697_abnormal_eye_size | 0.86970426 |
76 | MP0003755_abnormal_palate_morphology | 0.86284520 |
77 | MP0005423_abnormal_somatic_nervous | 0.84882178 |
78 | MP0000778_abnormal_nervous_system | 0.84612390 |
79 | MP0003942_abnormal_urinary_system | 0.84453297 |
80 | MP0005391_vision/eye_phenotype | 0.83430442 |
81 | MP0002233_abnormal_nose_morphology | 0.82696199 |
82 | MP0003122_maternal_imprinting | 0.82554728 |
83 | MP0005551_abnormal_eye_electrophysiolog | 0.81463583 |
84 | MP0004742_abnormal_vestibular_system | 0.81226828 |
85 | MP0005410_abnormal_fertilization | 0.80650215 |
86 | MP0002282_abnormal_trachea_morphology | 0.80554419 |
87 | MP0000350_abnormal_cell_proliferation | 0.80484913 |
88 | MP0003861_abnormal_nervous_system | 0.80331286 |
89 | MP0000358_abnormal_cell_content/ | 0.78720362 |
90 | MP0002111_abnormal_tail_morphology | 0.78577648 |
91 | MP0002752_abnormal_somatic_nervous | 0.77938537 |
92 | MP0002085_abnormal_embryonic_tissue | 0.76877600 |
93 | MP0002095_abnormal_skin_pigmentation | 0.76066112 |
94 | MP0005195_abnormal_posterior_eye | 0.75498209 |
95 | MP0002092_abnormal_eye_morphology | 0.73491521 |
96 | MP0009046_muscle_twitch | 0.73065155 |
97 | MP0003137_abnormal_impulse_conducting | 0.72348551 |
98 | MP0005253_abnormal_eye_physiology | 0.72041731 |
99 | MP0000313_abnormal_cell_death | 0.71970366 |
100 | MP0009250_abnormal_appendicular_skeleto | 0.70256322 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.59182634 |
2 | Reticulocytopenia (HP:0001896) | 4.38180612 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.34059550 |
4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.32309630 |
5 | Mitochondrial inheritance (HP:0001427) | 4.29246664 |
6 | Abnormal number of erythroid precursors (HP:0012131) | 4.25405191 |
7 | Acute encephalopathy (HP:0006846) | 4.06080619 |
8 | Increased CSF lactate (HP:0002490) | 3.73334713 |
9 | Hepatocellular necrosis (HP:0001404) | 3.72359581 |
10 | Rib fusion (HP:0000902) | 3.62143468 |
11 | Progressive macrocephaly (HP:0004481) | 3.61712819 |
12 | Macrocytic anemia (HP:0001972) | 3.38756771 |
13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.38202904 |
14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.35651761 |
15 | Hepatic necrosis (HP:0002605) | 3.33018482 |
16 | Renal Fanconi syndrome (HP:0001994) | 2.99316299 |
17 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.98478389 |
18 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.97306949 |
19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.97229137 |
20 | Pallor (HP:0000980) | 2.87488087 |
21 | Cerebral edema (HP:0002181) | 2.84171988 |
22 | Birth length less than 3rd percentile (HP:0003561) | 2.81643961 |
23 | Increased intramyocellular lipid droplets (HP:0012240) | 2.78446944 |
24 | Chromsome breakage (HP:0040012) | 2.73964445 |
25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.69845624 |
26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.69845624 |
27 | 3-Methylglutaconic aciduria (HP:0003535) | 2.66750712 |
28 | Absent thumb (HP:0009777) | 2.60891925 |
29 | Increased muscle lipid content (HP:0009058) | 2.59816849 |
30 | Pancreatic fibrosis (HP:0100732) | 2.55534271 |
31 | Lactic acidosis (HP:0003128) | 2.53972677 |
32 | Microvesicular hepatic steatosis (HP:0001414) | 2.53692450 |
33 | Increased serum lactate (HP:0002151) | 2.52763272 |
34 | Patellar aplasia (HP:0006443) | 2.46433245 |
35 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.43940118 |
36 | Abnormality of midbrain morphology (HP:0002418) | 2.41232062 |
37 | Molar tooth sign on MRI (HP:0002419) | 2.41232062 |
38 | Exercise intolerance (HP:0003546) | 2.38982313 |
39 | Testicular atrophy (HP:0000029) | 2.37609094 |
40 | Meckel diverticulum (HP:0002245) | 2.37247811 |
41 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.36800068 |
42 | Abnormality of the ileum (HP:0001549) | 2.36302526 |
43 | Abnormal number of incisors (HP:0011064) | 2.34610082 |
44 | Microretrognathia (HP:0000308) | 2.30376689 |
45 | Hyperthyroidism (HP:0000836) | 2.28569460 |
46 | Triphalangeal thumb (HP:0001199) | 2.28441276 |
47 | Sclerocornea (HP:0000647) | 2.22579207 |
48 | Respiratory failure (HP:0002878) | 2.21971731 |
49 | Pancreatic cysts (HP:0001737) | 2.19774087 |
50 | Optic disc pallor (HP:0000543) | 2.18660058 |
51 | Septo-optic dysplasia (HP:0100842) | 2.14392882 |
52 | Horseshoe kidney (HP:0000085) | 2.13803007 |
53 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.13090332 |
54 | Respiratory difficulties (HP:0002880) | 2.12829496 |
55 | True hermaphroditism (HP:0010459) | 2.12356516 |
56 | Cerebral hypomyelination (HP:0006808) | 2.10109269 |
57 | Concave nail (HP:0001598) | 2.08485919 |
58 | Pendular nystagmus (HP:0012043) | 2.08261777 |
59 | Abnormality of the preputium (HP:0100587) | 2.05758718 |
60 | Progressive microcephaly (HP:0000253) | 2.04574910 |
61 | Exertional dyspnea (HP:0002875) | 2.01417465 |
62 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.01210480 |
63 | Nephronophthisis (HP:0000090) | 1.99647044 |
64 | Cleft eyelid (HP:0000625) | 1.97443068 |
65 | Leukodystrophy (HP:0002415) | 1.96151447 |
66 | Pancytopenia (HP:0001876) | 1.95529894 |
67 | Aplastic anemia (HP:0001915) | 1.91988813 |
68 | Ectopic kidney (HP:0000086) | 1.90647370 |
69 | Flat capital femoral epiphysis (HP:0003370) | 1.86348079 |
70 | Hyperglycinemia (HP:0002154) | 1.85512408 |
71 | Short thumb (HP:0009778) | 1.85385186 |
72 | Lethargy (HP:0001254) | 1.84855592 |
73 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.82642463 |
74 | Breast hypoplasia (HP:0003187) | 1.81978736 |
75 | Truncus arteriosus (HP:0001660) | 1.81342592 |
76 | Abnormality of the carotid arteries (HP:0005344) | 1.79480462 |
77 | Holoprosencephaly (HP:0001360) | 1.77047846 |
78 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.76966389 |
79 | Congenital stationary night blindness (HP:0007642) | 1.76147488 |
80 | Emotional lability (HP:0000712) | 1.74633029 |
81 | Hypoplasia of the radius (HP:0002984) | 1.74495328 |
82 | Preaxial hand polydactyly (HP:0001177) | 1.74458103 |
83 | Occipital encephalocele (HP:0002085) | 1.74441691 |
84 | Opisthotonus (HP:0002179) | 1.74095312 |
85 | Esophageal atresia (HP:0002032) | 1.72337303 |
86 | Methylmalonic aciduria (HP:0012120) | 1.72024349 |
87 | Abnormality of renal resorption (HP:0011038) | 1.71336055 |
88 | Hyperglycinuria (HP:0003108) | 1.69869735 |
89 | Rectal fistula (HP:0100590) | 1.69781409 |
90 | Rectovaginal fistula (HP:0000143) | 1.69781409 |
91 | Hypoplastic pelvis (HP:0008839) | 1.69402121 |
92 | Anencephaly (HP:0002323) | 1.67850872 |
93 | Aplasia involving forearm bones (HP:0009822) | 1.67692724 |
94 | Absent forearm bone (HP:0003953) | 1.67692724 |
95 | Anophthalmia (HP:0000528) | 1.66964305 |
96 | Abnormality of DNA repair (HP:0003254) | 1.66518186 |
97 | Colon cancer (HP:0003003) | 1.66000945 |
98 | Optic nerve coloboma (HP:0000588) | 1.65402557 |
99 | Aganglionic megacolon (HP:0002251) | 1.64643618 |
100 | CNS demyelination (HP:0007305) | 1.64571658 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 4.34279975 |
2 | CDC7 | 3.96368014 |
3 | BUB1 | 3.42003204 |
4 | BCKDK | 3.06434848 |
5 | NME2 | 3.01110869 |
6 | STK16 | 2.88421356 |
7 | TLK1 | 2.85584014 |
8 | ZAK | 2.45311203 |
9 | PLK4 | 2.37872267 |
10 | TRIM28 | 2.36656008 |
11 | NUAK1 | 2.30783262 |
12 | NME1 | 2.29976749 |
13 | PNCK | 2.26892365 |
14 | WEE1 | 2.20315337 |
15 | VRK1 | 2.09438822 |
16 | DYRK2 | 1.91995383 |
17 | SRPK1 | 1.75720132 |
18 | MAPK15 | 1.72656777 |
19 | AURKA | 1.70024134 |
20 | WNK4 | 1.67489976 |
21 | CHEK2 | 1.65332911 |
22 | PLK1 | 1.59608969 |
23 | ATR | 1.55769226 |
24 | MAP3K11 | 1.50223514 |
25 | PASK | 1.39950955 |
26 | TESK2 | 1.35830073 |
27 | CSNK1G3 | 1.30427204 |
28 | AURKB | 1.28947090 |
29 | KDR | 1.27285031 |
30 | NEK2 | 1.25593998 |
31 | DYRK3 | 1.23470070 |
32 | BMPR1B | 1.20880044 |
33 | PDK2 | 1.19535941 |
34 | TTK | 1.17538211 |
35 | BRSK1 | 1.16838294 |
36 | CDK8 | 1.14659484 |
37 | TAF1 | 1.12826145 |
38 | CCNB1 | 1.07698408 |
39 | CSNK1G2 | 1.04698384 |
40 | MAP4K2 | 1.00376397 |
41 | CSNK1G1 | 0.98417255 |
42 | PLK3 | 0.98218613 |
43 | EPHB2 | 0.97388447 |
44 | MAP2K7 | 0.95973755 |
45 | WNK3 | 0.95249530 |
46 | LRRK2 | 0.94099915 |
47 | CDK7 | 0.93384579 |
48 | IRAK2 | 0.89297968 |
49 | RPS6KA5 | 0.88605958 |
50 | PBK | 0.87152571 |
51 | ADRBK2 | 0.82984603 |
52 | CHEK1 | 0.82861847 |
53 | PIM2 | 0.81647088 |
54 | ABL2 | 0.79273242 |
55 | BRSK2 | 0.78476090 |
56 | CSNK2A1 | 0.77499674 |
57 | CSNK2A2 | 0.76345180 |
58 | CDK19 | 0.72572419 |
59 | GRK1 | 0.72342844 |
60 | RPS6KB2 | 0.71443702 |
61 | PRKCI | 0.69471968 |
62 | ATM | 0.67959768 |
63 | CSNK1E | 0.65648831 |
64 | CDK2 | 0.64723440 |
65 | CDK4 | 0.64114536 |
66 | ILK | 0.60813500 |
67 | MAP3K10 | 0.58698482 |
68 | NEK1 | 0.56697755 |
69 | CDK1 | 0.56325499 |
70 | CSNK1A1 | 0.54550490 |
71 | CSNK1A1L | 0.53611698 |
72 | EPHA4 | 0.49478856 |
73 | DYRK1B | 0.48946945 |
74 | PRKCG | 0.46260090 |
75 | IKBKB | 0.45536259 |
76 | PINK1 | 0.44491657 |
77 | RPS6KA4 | 0.44178827 |
78 | DAPK3 | 0.44032351 |
79 | MAPK13 | 0.40345618 |
80 | MAP2K4 | 0.37735205 |
81 | LIMK1 | 0.37012498 |
82 | INSRR | 0.36655139 |
83 | PRKDC | 0.35913596 |
84 | BRAF | 0.34998180 |
85 | STK4 | 0.34888542 |
86 | CDK3 | 0.34358795 |
87 | STK39 | 0.30909385 |
88 | SIK2 | 0.30719864 |
89 | AKT1 | 0.30280691 |
90 | GRK6 | 0.29665110 |
91 | SMG1 | 0.29479181 |
92 | CDK11A | 0.29378957 |
93 | MUSK | 0.29258945 |
94 | MAPKAPK3 | 0.28664835 |
95 | PRKD3 | 0.28435805 |
96 | RPS6KA6 | 0.28177364 |
97 | MAP2K2 | 0.27634760 |
98 | PAK1 | 0.27244940 |
99 | PRKD2 | 0.27214718 |
100 | PIM1 | 0.27110223 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.47293332 |
2 | DNA replication_Homo sapiens_hsa03030 | 3.98513100 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.85950683 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.41031749 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.10306664 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 3.07043209 |
7 | Base excision repair_Homo sapiens_hsa03410 | 2.94953612 |
8 | Mismatch repair_Homo sapiens_hsa03430 | 2.89520282 |
9 | Sulfur relay system_Homo sapiens_hsa04122 | 2.73744055 |
10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.68360392 |
11 | Proteasome_Homo sapiens_hsa03050 | 2.60217013 |
12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.55430597 |
13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.39461021 |
14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.37057279 |
15 | Spliceosome_Homo sapiens_hsa03040 | 2.35279733 |
16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.15587037 |
17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.10445173 |
18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.06577191 |
19 | Alzheimers disease_Homo sapiens_hsa05010 | 2.06520744 |
20 | Protein export_Homo sapiens_hsa03060 | 1.68287984 |
21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.63413357 |
22 | RNA transport_Homo sapiens_hsa03013 | 1.61627410 |
23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.56807749 |
24 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.54840406 |
25 | RNA degradation_Homo sapiens_hsa03018 | 1.47855536 |
26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.40693755 |
27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34989674 |
28 | Purine metabolism_Homo sapiens_hsa00230 | 1.33512005 |
29 | Cell cycle_Homo sapiens_hsa04110 | 1.27984626 |
30 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.22262576 |
31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.18978246 |
32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.11881912 |
33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.03358548 |
34 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.03280388 |
35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.98555787 |
36 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.98209086 |
37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.95232211 |
38 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.89432810 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.87482824 |
40 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.85224534 |
41 | Metabolic pathways_Homo sapiens_hsa01100 | 0.82351877 |
42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78718182 |
43 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.76234538 |
44 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.76176367 |
45 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.69638460 |
46 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65444235 |
47 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.64452684 |
48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.61670744 |
49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.59887226 |
50 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.59623642 |
51 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56482153 |
52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.55185250 |
53 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.52169427 |
54 | Peroxisome_Homo sapiens_hsa04146 | 0.51327200 |
55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.47977163 |
56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.46609106 |
57 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45420020 |
58 | Phototransduction_Homo sapiens_hsa04744 | 0.45275017 |
59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.42820620 |
60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.42581249 |
61 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42310274 |
62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42223407 |
63 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.41235856 |
64 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.38269124 |
65 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.37399550 |
66 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.37101798 |
67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36769859 |
68 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35605191 |
69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35082744 |
70 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.34495376 |
71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.33682980 |
72 | Alcoholism_Homo sapiens_hsa05034 | 0.32892264 |
73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.32809667 |
74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31841851 |
75 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.30898645 |
76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.30240165 |
77 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.29958254 |
78 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29811690 |
79 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.26807959 |
80 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.26446114 |
81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26239642 |
82 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.25444938 |
83 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.25216928 |
84 | Nicotine addiction_Homo sapiens_hsa05033 | 0.24901022 |
85 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23960463 |
86 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.23004056 |
87 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.22957027 |
88 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22818899 |
89 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.22375541 |
90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21591472 |
91 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.21572684 |
92 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.20478730 |
93 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.19303577 |
94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19269763 |
95 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.18894112 |
96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.15484165 |
97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.14703685 |
98 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.14067269 |
99 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.13049839 |
100 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.11854349 |