C1ORF43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.24175638
2Golgi transport vesicle coating (GO:0048200)7.24175638
3NADH metabolic process (GO:0006734)5.46575977
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.59278879
5proline biosynthetic process (GO:0006561)4.50479212
6tricarboxylic acid cycle (GO:0006099)4.49365071
7protein maturation by protein folding (GO:0022417)4.41772493
8gluconeogenesis (GO:0006094)4.15420851
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.96844346
10protein retention in ER lumen (GO:0006621)3.92575489
11hexose biosynthetic process (GO:0019319)3.89017630
12nucleobase-containing small molecule interconversion (GO:0015949)3.80685987
13monosaccharide biosynthetic process (GO:0046364)3.79918124
14L-serine metabolic process (GO:0006563)3.67385403
15oxaloacetate metabolic process (GO:0006107)3.65413486
16regulation of translational fidelity (GO:0006450)3.59411536
17formation of translation preinitiation complex (GO:0001731)3.50354587
18proline metabolic process (GO:0006560)3.27746880
19vesicle coating (GO:0006901)3.26133279
20glycolytic process (GO:0006096)3.25882980
21tricarboxylic acid metabolic process (GO:0072350)3.25730889
22COPII vesicle coating (GO:0048208)3.23727214
23oxidative phosphorylation (GO:0006119)3.21955379
24pentose-phosphate shunt (GO:0006098)3.21899262
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16850776
26pteridine-containing compound biosynthetic process (GO:0042559)3.04761803
27fructose metabolic process (GO:0006000)3.03677399
28NADPH regeneration (GO:0006740)2.99691710
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97501626
30L-phenylalanine metabolic process (GO:0006558)2.97501626
31tRNA aminoacylation for protein translation (GO:0006418)2.95767811
32ribosome assembly (GO:0042255)2.94651373
33glucose catabolic process (GO:0006007)2.90477533
34mitochondrial fusion (GO:0008053)2.88264244
35tRNA aminoacylation (GO:0043039)2.82669738
36amino acid activation (GO:0043038)2.82669738
37regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80981876
38activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.79727454
39glutamine family amino acid biosynthetic process (GO:0009084)2.79717332
40nucleoside diphosphate biosynthetic process (GO:0009133)2.77967044
41urea cycle (GO:0000050)2.76973587
424-hydroxyproline metabolic process (GO:0019471)2.76390942
43nitrogen cycle metabolic process (GO:0071941)2.76114900
44positive regulation of nuclease activity (GO:0032075)2.72298450
45glucose 6-phosphate metabolic process (GO:0051156)2.67787727
46urea metabolic process (GO:0019627)2.67123621
47serine family amino acid biosynthetic process (GO:0009070)2.67023688
48peptidyl-proline hydroxylation (GO:0019511)2.64249698
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63807398
50glycosphingolipid catabolic process (GO:0046479)2.62386710
51regulation of early endosome to late endosome transport (GO:2000641)2.62233828
52biotin metabolic process (GO:0006768)2.61321611
53pteridine-containing compound metabolic process (GO:0042558)2.61264240
54pyruvate metabolic process (GO:0006090)2.61236696
55protein hydroxylation (GO:0018126)2.58337200
56mitotic nuclear envelope reassembly (GO:0007084)2.56338584
57nuclear envelope reassembly (GO:0031468)2.56338584
58tetrahydrofolate metabolic process (GO:0046653)2.55163474
59regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50797000
60folic acid-containing compound biosynthetic process (GO:0009396)2.50477548
61regulation of cellular amino acid metabolic process (GO:0006521)2.48792221
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.48751226
63glycolipid catabolic process (GO:0019377)2.48444730
64negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47642384
65alpha-amino acid biosynthetic process (GO:1901607)2.47438175
66mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.46418936
67succinate metabolic process (GO:0006105)2.46146687
68deoxyribonucleotide biosynthetic process (GO:0009263)2.45914133
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45051164
70folic acid-containing compound metabolic process (GO:0006760)2.44303378
71AMP metabolic process (GO:0046033)2.41667687
72GDP-mannose metabolic process (GO:0019673)2.41662174
73endoplasmic reticulum unfolded protein response (GO:0030968)2.41469848
74protein targeting to mitochondrion (GO:0006626)2.40773746
75de novo posttranslational protein folding (GO:0051084)2.40680366
76regulation of nuclease activity (GO:0032069)2.38168489
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.36912420
78de novo protein folding (GO:0006458)2.36577408
79regulation of mitochondrial translation (GO:0070129)2.36498483
80alpha-linolenic acid metabolic process (GO:0036109)2.36381623
81ER-nucleus signaling pathway (GO:0006984)2.36205788
82negative regulation of cell size (GO:0045792)2.36128714
83glucose metabolic process (GO:0006006)2.34999097
84branched-chain amino acid catabolic process (GO:0009083)2.34630410
85aerobic respiration (GO:0009060)2.34270131
86cellular protein complex localization (GO:0034629)2.34227271
87protein complex localization (GO:0031503)2.32485820
88ribosomal large subunit biogenesis (GO:0042273)2.32463663
89ribosomal small subunit biogenesis (GO:0042274)2.32213317
90chaperone-mediated protein folding (GO:0061077)2.30858181
91endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29747103
92muscle cell cellular homeostasis (GO:0046716)2.29134083
93amyloid precursor protein catabolic process (GO:0042987)2.28974610
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.28645539
95proteasome assembly (GO:0043248)2.28555645
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.28168638
97negative regulation of ligase activity (GO:0051352)2.28168638
98NADP metabolic process (GO:0006739)2.28098800
99creatine metabolic process (GO:0006600)2.27461876
100doxorubicin metabolic process (GO:0044598)2.26517918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72983548
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09763043
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.05322859
4ZNF263_19887448_ChIP-Seq_K562_Human3.03561392
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99580461
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64075287
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62623120
8E2F7_22180533_ChIP-Seq_HELA_Human2.45641060
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41632548
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39944733
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37971892
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35988694
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34751589
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34681286
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29119194
16ZFX_18555785_ChIP-Seq_MESCs_Mouse2.23146695
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12979597
18* XRN2_22483619_ChIP-Seq_HELA_Human2.11651250
19DCP1A_22483619_ChIP-Seq_HELA_Human2.09853588
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.09408683
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02036339
22CLOCK_20551151_ChIP-Seq_293T_Human2.00924823
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95287269
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90113152
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.86849838
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85803350
27AR_21909140_ChIP-Seq_LNCAP_Human1.85750071
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85533575
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84233733
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83769942
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82682128
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75440845
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74911854
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70584336
35GABP_19822575_ChIP-Seq_HepG2_Human1.69808238
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68196740
37* TFEB_21752829_ChIP-Seq_HELA_Human1.67619443
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.63501475
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62819026
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61598089
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61517520
42KDM5A_27292631_Chip-Seq_BREAST_Human1.60750011
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.60425781
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.54903082
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54628345
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53199603
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53181796
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50614008
49TTF2_22483619_ChIP-Seq_HELA_Human1.44490410
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41547541
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39313855
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37966454
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36602780
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.36243263
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35866501
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34517314
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33901729
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33414852
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32936681
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.32290668
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.31391993
62LXR_22292898_ChIP-Seq_THP-1_Human1.30923593
63TBX5_21415370_ChIP-Seq_HL-1_Mouse1.30118963
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26756568
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24749475
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.24515321
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24043190
68ATF3_27146783_Chip-Seq_COLON_Human1.23065098
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23044389
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22895053
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22749534
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.22489743
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22110746
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21466906
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.21302430
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18936533
77CHD1_26751641_Chip-Seq_LNCaP_Human1.17089625
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15986649
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15826566
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14921397
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14634297
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12540996
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11362254
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09566917
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08214375
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07790315
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07033669
88TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06589708
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06439945
90* ELK3_25401928_ChIP-Seq_HUVEC_Human1.05065030
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05051151
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04964602
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04274527
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03423954
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03245524
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01755378
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01580040
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00931439
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00176674
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99625292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.80721845
2MP0005058_abnormal_lysosome_morphology3.79693528
3MP0004233_abnormal_muscle_weight3.61186506
4MP0010234_abnormal_vibrissa_follicle3.39152702
5MP0002877_abnormal_melanocyte_morpholog3.32207086
6MP0003806_abnormal_nucleotide_metabolis2.92910811
7MP0009840_abnormal_foam_cell2.67164172
8MP0000751_myopathy2.62417360
9MP0000747_muscle_weakness2.51914131
10MP0000749_muscle_degeneration2.33412130
11MP0006036_abnormal_mitochondrial_physio2.25803125
12MP0005408_hypopigmentation2.24149757
13MP0003705_abnormal_hypodermis_morpholog2.10635019
14MP0002269_muscular_atrophy2.05390016
15MP0003693_abnormal_embryo_hatching1.92688392
16MP0003186_abnormal_redox_activity1.90010177
17MP0005330_cardiomyopathy1.87703070
18MP0001661_extended_life_span1.85709663
19MP0004185_abnormal_adipocyte_glucose1.83128515
20MP0009780_abnormal_chondrocyte_physiolo1.77008636
21MP0000759_abnormal_skeletal_muscle1.75790029
22MP0000750_abnormal_muscle_regeneration1.73872190
23MP0008260_abnormal_autophagy1.66230981
24MP0002139_abnormal_hepatobiliary_system1.65929334
25MP0004087_abnormal_muscle_fiber1.64230279
26MP0004957_abnormal_blastocyst_morpholog1.56249015
27MP0001727_abnormal_embryo_implantation1.55626093
28MP0004858_abnormal_nervous_system1.52708339
29MP0000003_abnormal_adipose_tissue1.52496846
30MP0003191_abnormal_cellular_cholesterol1.51376496
31MP0005670_abnormal_white_adipose1.48815163
32MP0004782_abnormal_surfactant_physiolog1.45150933
33MP0000358_abnormal_cell_content/1.43248959
34MP0004036_abnormal_muscle_relaxation1.41553147
35MP0002796_impaired_skin_barrier1.37641170
36MP0003221_abnormal_cardiomyocyte_apopto1.37600807
37MP0006035_abnormal_mitochondrial_morpho1.36890679
38MP0003111_abnormal_nucleus_morphology1.36234329
39MP0008932_abnormal_embryonic_tissue1.35856698
40MP0001730_embryonic_growth_arrest1.35803229
41MP0008007_abnormal_cellular_replicative1.34436543
42MP0005501_abnormal_skin_physiology1.33875783
43MP0005365_abnormal_bile_salt1.33140726
44MP0005666_abnormal_adipose_tissue1.32873532
45MP0003941_abnormal_skin_development1.30655968
46MP0002090_abnormal_vision1.30398270
47MP0000013_abnormal_adipose_tissue1.25201559
48MP0005332_abnormal_amino_acid1.24668815
49MP0005248_abnormal_Harderian_gland1.22588060
50MP0003123_paternal_imprinting1.20565421
51MP0009672_abnormal_birth_weight1.19400343
52MP0003077_abnormal_cell_cycle1.19371713
53MP0001346_abnormal_lacrimal_gland1.19353504
54MP0005375_adipose_tissue_phenotype1.19181515
55MP0002909_abnormal_adrenal_gland1.14949542
56MP0000733_abnormal_muscle_development1.14225615
57MP0002106_abnormal_muscle_physiology1.11336521
58MP0004510_myositis1.11150966
59MP0005623_abnormal_meninges_morphology1.10483918
60MP0005584_abnormal_enzyme/coenzyme_acti1.09072267
61MP0003172_abnormal_lysosome_physiology1.09063667
62MP0002822_catalepsy1.07668886
63MP0005360_urolithiasis1.06404259
64MP0004084_abnormal_cardiac_muscle1.04488950
65MP0002971_abnormal_brown_adipose1.04303391
66MP0000609_abnormal_liver_physiology1.00189174
67MP0002837_dystrophic_cardiac_calcinosis0.99853930
68MP0005319_abnormal_enzyme/_coenzyme0.97842748
69MP0005165_increased_susceptibility_to0.96332641
70MP0003453_abnormal_keratinocyte_physiol0.94664821
71MP0000372_irregular_coat_pigmentation0.92795009
72MP0001881_abnormal_mammary_gland0.91384085
73MP0003868_abnormal_feces_composition0.91341942
74MP0004145_abnormal_muscle_electrophysio0.90105458
75MP0002332_abnormal_exercise_endurance0.90081788
76MP0003879_abnormal_hair_cell0.89100789
77MP0005257_abnormal_intraocular_pressure0.87707281
78MP0000350_abnormal_cell_proliferation0.87017781
79MP0002080_prenatal_lethality0.86487478
80MP0002896_abnormal_bone_mineralization0.86462683
81MP0000678_abnormal_parathyroid_gland0.86351867
82MP0005369_muscle_phenotype0.85076634
83MP0005083_abnormal_biliary_tract0.84092536
84MP0009697_abnormal_copulation0.83904761
85MP0000681_abnormal_thyroid_gland0.83828482
86MP0010030_abnormal_orbit_morphology0.83433834
87MP0003566_abnormal_cell_adhesion0.82494829
88MP0001666_abnormal_nutrient_absorption0.80333647
89MP0002972_abnormal_cardiac_muscle0.80232546
90MP0008438_abnormal_cutaneous_collagen0.79778315
91MP0000627_abnormal_mammary_gland0.77948792
92MP0001764_abnormal_homeostasis0.77728784
93MP0003634_abnormal_glial_cell0.75446398
94MP0003329_amyloid_beta_deposits0.74637284
95MP0000343_altered_response_to0.74321163
96MP0003646_muscle_fatigue0.74251582
97MP0010630_abnormal_cardiac_muscle0.74018689
98MP0005379_endocrine/exocrine_gland_phen0.73165465
99MP0009643_abnormal_urine_homeostasis0.72454574
100MP0002060_abnormal_skin_morphology0.71922942

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.09656519
2Increased serum pyruvate (HP:0003542)3.72214976
3Exercise-induced muscle cramps (HP:0003710)3.62427815
4Rhabdomyolysis (HP:0003201)3.61151020
5Nemaline bodies (HP:0003798)3.59870731
6Myoglobinuria (HP:0002913)3.46654679
7Vertebral compression fractures (HP:0002953)3.43626367
8Distal lower limb muscle weakness (HP:0009053)3.39243143
9Muscle fiber inclusion bodies (HP:0100299)3.38026858
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.32176330
11Cholecystitis (HP:0001082)3.29902053
12Abnormal gallbladder physiology (HP:0012438)3.29902053
13Exercise-induced myalgia (HP:0003738)3.19514496
14Ragged-red muscle fibers (HP:0003200)3.03004502
15Microvesicular hepatic steatosis (HP:0001414)2.93558742
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92044596
17Myopathic facies (HP:0002058)2.81916276
18Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81221323
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.72108533
20Hypokinesia (HP:0002375)2.70922004
21EMG: myopathic abnormalities (HP:0003458)2.62082035
22Hyperammonemia (HP:0001987)2.58500093
23Achilles tendon contracture (HP:0001771)2.48519111
24Distal lower limb amyotrophy (HP:0008944)2.47579821
25Abnormality of the Achilles tendon (HP:0005109)2.43582684
26Cholelithiasis (HP:0001081)2.38498198
27Progressive muscle weakness (HP:0003323)2.36674350
28Multiple enchondromatosis (HP:0005701)2.36104791
29Abnormality of the distal phalanges of the toes (HP:0010182)2.34280303
30Abnormality of glycolipid metabolism (HP:0010969)2.34082822
31Abnormality of liposaccharide metabolism (HP:0010968)2.34082822
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.34082822
33Abnormality of fatty-acid metabolism (HP:0004359)2.33774264
34Abnormal gallbladder morphology (HP:0012437)2.29867808
35Hypoglycemic coma (HP:0001325)2.28792362
36Trismus (HP:0000211)2.25832976
37Hand muscle atrophy (HP:0009130)2.24076133
38Distal upper limb amyotrophy (HP:0007149)2.22660222
39Upper limb amyotrophy (HP:0009129)2.22660222
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20381608
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20381608
42Reduced antithrombin III activity (HP:0001976)2.15578062
43Insidious onset (HP:0003587)2.15057543
44Termporal pattern (HP:0011008)2.15057543
45Hyperparathyroidism (HP:0000843)2.14088410
46Limb-girdle muscle atrophy (HP:0003797)2.13684600
47Gout (HP:0001997)2.13502059
48Axonal loss (HP:0003447)2.11379413
49Upper limb muscle weakness (HP:0003484)2.10978965
50Exercise intolerance (HP:0003546)2.07558297
51Abnormal mitochondria in muscle tissue (HP:0008316)2.06038819
52Cerebral hypomyelination (HP:0006808)2.05574576
53Increased intramyocellular lipid droplets (HP:0012240)2.05002631
54Asymmetric septal hypertrophy (HP:0001670)2.02857901
55Spastic paraparesis (HP:0002313)2.01829184
56Abnormality of the umbilical cord (HP:0010881)2.00709348
57Abnormality of the gallbladder (HP:0005264)1.97983578
58Cerebral edema (HP:0002181)1.97762368
59Progressive external ophthalmoplegia (HP:0000590)1.97555477
60Testicular atrophy (HP:0000029)1.97194111
61Hepatic necrosis (HP:0002605)1.93119877
62Type 1 muscle fiber predominance (HP:0003803)1.92936828
63Abnormality of the anterior horn cell (HP:0006802)1.92204189
64Degeneration of anterior horn cells (HP:0002398)1.92204189
65Acute encephalopathy (HP:0006846)1.91703511
66Abnormality of skeletal muscle fiber size (HP:0012084)1.90303679
67Abnormalities of placenta or umbilical cord (HP:0001194)1.89460039
68Muscle stiffness (HP:0003552)1.87996654
69Type I transferrin isoform profile (HP:0003642)1.87232323
70Increased muscle lipid content (HP:0009058)1.85752732
71Lactic acidosis (HP:0003128)1.83847515
72Neck muscle weakness (HP:0000467)1.83823564
73Calcaneovalgus deformity (HP:0001848)1.82028079
74Abnormal cartilage morphology (HP:0002763)1.81727700
75Tetraparesis (HP:0002273)1.81296999
76Back pain (HP:0003418)1.80820790
77Acute necrotizing encephalopathy (HP:0006965)1.79988138
78Generalized aminoaciduria (HP:0002909)1.79885853
79Fasciculations (HP:0002380)1.79171200
80Loss of speech (HP:0002371)1.77250670
81Diminished movement (HP:0002374)1.77164372
82Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75885091
83Increased connective tissue (HP:0009025)1.75793791
84Growth hormone excess (HP:0000845)1.74946989
85Foot dorsiflexor weakness (HP:0009027)1.74190879
86Mildly elevated creatine phosphokinase (HP:0008180)1.72934901
87Round ear (HP:0100830)1.72615521
88Paraparesis (HP:0002385)1.70877197
89J-shaped sella turcica (HP:0002680)1.69841161
90Deep venous thrombosis (HP:0002625)1.69039514
91Hyporeflexia of lower limbs (HP:0002600)1.68993919
92Pheochromocytoma (HP:0002666)1.67395805
93Lower limb amyotrophy (HP:0007210)1.66574961
94Prolonged neonatal jaundice (HP:0006579)1.65782092
95Symptomatic seizures (HP:0011145)1.65759106
96Fetal akinesia sequence (HP:0001989)1.65745648
97Unilateral renal agenesis (HP:0000122)1.65372294
98Hepatocellular necrosis (HP:0001404)1.64508969
99Abnormality of the calf musculature (HP:0001430)1.64336232
100Amniotic constriction ring (HP:0009775)1.64312796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.05913311
2IRAK33.33205491
3TESK13.07499546
4SCYL23.04204130
5EIF2AK13.00227709
6TRIB32.95141604
7NEK12.61309707
8ARAF2.45810106
9MST1R2.32795919
10PIM22.21067357
11EPHA22.14274772
12LIMK12.07163967
13PAK41.89917329
14BUB11.86669749
15STK161.86590760
16EEF2K1.85157300
17PDK21.78018498
18PBK1.75272739
19ICK1.70155538
20MAP3K121.68842017
21MAPKAPK31.61622416
22SRPK11.57826355
23EIF2AK31.57689591
24PHKG11.55055604
25PHKG21.55055604
26ERN11.46274632
27OBSCN1.46021888
28TESK21.41554472
29SMG11.38829984
30TTN1.35602369
31MET1.31600649
32BCKDK1.27921429
33LMTK21.15786325
34PRKD31.14471883
35ILK1.10161511
36MAP3K91.08780793
37SIK11.07187863
38PKN21.04602827
39PRPF4B1.02332548
40VRK21.01996260
41RPS6KB21.00002472
42SIK30.99813845
43BRAF0.99422543
44LATS20.98855877
45AKT20.98772233
46LRRK20.95518466
47ABL20.94665938
48TRIM280.93686472
49DAPK10.89588513
50TTK0.89380823
51KSR20.88821654
52TAOK20.88242352
53TSSK60.88014831
54CAMK2G0.85516281
55ERBB30.84174809
56PTK20.82414409
57MAP3K30.81127634
58BRSK10.75928738
59MAPKAPK50.75128162
60CDK70.70009451
61CDK140.67323498
62CSNK1G30.66623850
63MAP3K80.64880025
64CDK60.63245395
65CDK180.62706697
66PDPK10.61886777
67CDK150.59955135
68DDR20.59869105
69CDK11A0.59586145
70PRKCI0.59261277
71NTRK10.57430799
72RIPK10.56369268
73DAPK30.55658697
74PDGFRA0.55322543
75MTOR0.54590013
76NME10.54346039
77AURKA0.54073535
78IRAK20.51657088
79CAMK2D0.50786288
80AURKB0.50685840
81ERBB40.50324972
82ALK0.49208799
83NEK90.49141561
84PAK10.49017862
85MOS0.48255977
86TBK10.46536101
87FER0.45981139
88CSNK1A1L0.45038334
89RAF10.44228059
90MAP3K110.43161390
91RPS6KA40.42663024
92MUSK0.40932824
93MAPK110.39387360
94DYRK1B0.35335482
95PAK60.35021505
96CAMK2B0.30178238
97WEE10.29546580
98MAP3K50.29018382
99DMPK0.28803468
100CDK80.27854969

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.26101267
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.76918451
3Biosynthesis of amino acids_Homo sapiens_hsa012302.92745944
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91738242
5Carbon metabolism_Homo sapiens_hsa012002.65268664
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39474044
7Proteasome_Homo sapiens_hsa030502.35103049
8Pentose phosphate pathway_Homo sapiens_hsa000302.31011285
9Fatty acid elongation_Homo sapiens_hsa000622.24782404
10Pyruvate metabolism_Homo sapiens_hsa006202.12433942
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.96343951
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93034747
13Fructose and mannose metabolism_Homo sapiens_hsa000511.86447677
14Arginine biosynthesis_Homo sapiens_hsa002201.82664606
15Vitamin B6 metabolism_Homo sapiens_hsa007501.81077680
16Vibrio cholerae infection_Homo sapiens_hsa051101.75743275
17Arginine and proline metabolism_Homo sapiens_hsa003301.73261983
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73128138
19Sulfur metabolism_Homo sapiens_hsa009201.61242318
20Sulfur relay system_Homo sapiens_hsa041221.59799514
21Galactose metabolism_Homo sapiens_hsa000521.58084373
22Other glycan degradation_Homo sapiens_hsa005111.54803767
23Oxidative phosphorylation_Homo sapiens_hsa001901.54539822
24Phenylalanine metabolism_Homo sapiens_hsa003601.53109899
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.52636927
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42447110
27Fatty acid metabolism_Homo sapiens_hsa012121.41346300
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40968191
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35046068
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34505679
31One carbon pool by folate_Homo sapiens_hsa006701.27261265
32Parkinsons disease_Homo sapiens_hsa050121.26093241
33Folate biosynthesis_Homo sapiens_hsa007901.24944113
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.23837147
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20869087
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20666544
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19643029
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19201906
39DNA replication_Homo sapiens_hsa030301.16923937
40N-Glycan biosynthesis_Homo sapiens_hsa005101.12865900
41Fatty acid degradation_Homo sapiens_hsa000711.10341941
42Ribosome_Homo sapiens_hsa030101.07163185
43Glutathione metabolism_Homo sapiens_hsa004801.07016644
44Protein export_Homo sapiens_hsa030600.99732403
45Prion diseases_Homo sapiens_hsa050200.96318371
46Lysosome_Homo sapiens_hsa041420.96275136
47Pyrimidine metabolism_Homo sapiens_hsa002400.94942427
48Propanoate metabolism_Homo sapiens_hsa006400.93928683
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.92955178
50Alzheimers disease_Homo sapiens_hsa050100.92136233
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90441919
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90010776
53Base excision repair_Homo sapiens_hsa034100.87591970
54Tyrosine metabolism_Homo sapiens_hsa003500.86282951
55Mismatch repair_Homo sapiens_hsa034300.85848691
56Synaptic vesicle cycle_Homo sapiens_hsa047210.85739603
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84311869
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82789166
59Huntingtons disease_Homo sapiens_hsa050160.81929254
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78187872
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.77518686
62Steroid biosynthesis_Homo sapiens_hsa001000.77289712
63Collecting duct acid secretion_Homo sapiens_hsa049660.75321925
64beta-Alanine metabolism_Homo sapiens_hsa004100.72933928
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72781899
66Bladder cancer_Homo sapiens_hsa052190.70863548
67Cardiac muscle contraction_Homo sapiens_hsa042600.69946980
68Peroxisome_Homo sapiens_hsa041460.69547660
69RNA transport_Homo sapiens_hsa030130.69377085
70Metabolic pathways_Homo sapiens_hsa011000.69274181
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.69228710
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66929493
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66191647
74Insulin signaling pathway_Homo sapiens_hsa049100.61153096
75AMPK signaling pathway_Homo sapiens_hsa041520.60356859
76Thyroid cancer_Homo sapiens_hsa052160.60335391
77Spliceosome_Homo sapiens_hsa030400.59978762
78Sphingolipid metabolism_Homo sapiens_hsa006000.55573741
79Glucagon signaling pathway_Homo sapiens_hsa049220.55402147
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.53756749
81Starch and sucrose metabolism_Homo sapiens_hsa005000.51874440
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49442646
83PPAR signaling pathway_Homo sapiens_hsa033200.48377210
84Nucleotide excision repair_Homo sapiens_hsa034200.48207169
85Purine metabolism_Homo sapiens_hsa002300.45852237
86Butanoate metabolism_Homo sapiens_hsa006500.45676722
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43622262
88Tryptophan metabolism_Homo sapiens_hsa003800.38014419
89Fatty acid biosynthesis_Homo sapiens_hsa000610.37496774
90Histidine metabolism_Homo sapiens_hsa003400.36215270
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35828705
92RNA polymerase_Homo sapiens_hsa030200.34788892
93Selenocompound metabolism_Homo sapiens_hsa004500.32750690
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31174601
95Complement and coagulation cascades_Homo sapiens_hsa046100.24502188
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24168901
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21887435
98Lysine degradation_Homo sapiens_hsa003100.21274004
99Legionellosis_Homo sapiens_hsa051340.19908397
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18997509

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