Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.46667675 |
2 | proteasome assembly (GO:0043248) | 4.43508948 |
3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.27369205 |
4 | protein neddylation (GO:0045116) | 4.25559646 |
5 | cullin deneddylation (GO:0010388) | 4.25462039 |
6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.16847451 |
7 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.12931308 |
8 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.12931308 |
9 | NADH dehydrogenase complex assembly (GO:0010257) | 4.12931308 |
10 | chaperone-mediated protein transport (GO:0072321) | 4.12015631 |
11 | protein complex biogenesis (GO:0070271) | 4.01504813 |
12 | ATP synthesis coupled proton transport (GO:0015986) | 3.95442801 |
13 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.95442801 |
14 | protein deneddylation (GO:0000338) | 3.91078560 |
15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.79618878 |
16 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.78730493 |
17 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.77606305 |
18 | termination of RNA polymerase III transcription (GO:0006386) | 3.75083012 |
19 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.75083012 |
20 | protein-cofactor linkage (GO:0018065) | 3.74709548 |
21 | DNA damage response, detection of DNA damage (GO:0042769) | 3.74125601 |
22 | respiratory electron transport chain (GO:0022904) | 3.51368566 |
23 | electron transport chain (GO:0022900) | 3.45924051 |
24 | respiratory chain complex IV assembly (GO:0008535) | 3.45618729 |
25 | platelet dense granule organization (GO:0060155) | 3.41241367 |
26 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.39728816 |
27 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.39728816 |
28 | DNA double-strand break processing (GO:0000729) | 3.39373432 |
29 | organelle disassembly (GO:1903008) | 3.37701302 |
30 | chromatin remodeling at centromere (GO:0031055) | 3.33799112 |
31 | CENP-A containing nucleosome assembly (GO:0034080) | 3.24276160 |
32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.22547139 |
33 | rRNA modification (GO:0000154) | 3.11907850 |
34 | positive regulation of mitochondrial fission (GO:0090141) | 3.10177401 |
35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.08891843 |
36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.06070610 |
37 | protein localization to mitochondrion (GO:0070585) | 3.03863338 |
38 | regulation of helicase activity (GO:0051095) | 3.03748771 |
39 | ribonucleoprotein complex disassembly (GO:0032988) | 3.03632280 |
40 | histone mRNA metabolic process (GO:0008334) | 3.03607237 |
41 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.02946622 |
42 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.02946622 |
43 | protein targeting to mitochondrion (GO:0006626) | 3.01542086 |
44 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.98580199 |
45 | pseudouridine synthesis (GO:0001522) | 2.98383674 |
46 | protein K11-linked ubiquitination (GO:0070979) | 2.91311923 |
47 | replication fork processing (GO:0031297) | 2.90875336 |
48 | cytochrome complex assembly (GO:0017004) | 2.90260257 |
49 | negative regulation of ligase activity (GO:0051352) | 2.89110697 |
50 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.89110697 |
51 | establishment of protein localization to mitochondrion (GO:0072655) | 2.86382221 |
52 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.83929342 |
53 | peptidyl-histidine modification (GO:0018202) | 2.80904597 |
54 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.78417511 |
55 | maturation of 5.8S rRNA (GO:0000460) | 2.78085440 |
56 | spliceosomal snRNP assembly (GO:0000387) | 2.78077122 |
57 | histone exchange (GO:0043486) | 2.77018563 |
58 | single strand break repair (GO:0000012) | 2.76776502 |
59 | 7-methylguanosine mRNA capping (GO:0006370) | 2.74532767 |
60 | anterograde synaptic vesicle transport (GO:0048490) | 2.71919419 |
61 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.69706898 |
62 | 7-methylguanosine RNA capping (GO:0009452) | 2.66584276 |
63 | RNA capping (GO:0036260) | 2.66584276 |
64 | regulation of meiosis I (GO:0060631) | 2.65509881 |
65 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.65490352 |
66 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.65490352 |
67 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.65469434 |
68 | negative regulation of telomere maintenance (GO:0032205) | 2.65216769 |
69 | positive regulation of ligase activity (GO:0051351) | 2.65155244 |
70 | transcription from RNA polymerase III promoter (GO:0006383) | 2.64900873 |
71 | tRNA processing (GO:0008033) | 2.62776564 |
72 | inner mitochondrial membrane organization (GO:0007007) | 2.61699616 |
73 | resolution of meiotic recombination intermediates (GO:0000712) | 2.61450030 |
74 | negative regulation of DNA recombination (GO:0045910) | 2.61196835 |
75 | protein polyglutamylation (GO:0018095) | 2.61069875 |
76 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.60699842 |
77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.57048355 |
78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.57048355 |
79 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.57048355 |
80 | regulation of cilium movement (GO:0003352) | 2.56850635 |
81 | oxidative phosphorylation (GO:0006119) | 2.53715304 |
82 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.52603874 |
83 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.51295956 |
84 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.51295956 |
85 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.49563331 |
86 | rRNA methylation (GO:0031167) | 2.49487622 |
87 | regulation of mitochondrial translation (GO:0070129) | 2.49081658 |
88 | hydrogen ion transmembrane transport (GO:1902600) | 2.49070768 |
89 | ubiquinone metabolic process (GO:0006743) | 2.48276015 |
90 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.47705532 |
91 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.47282148 |
92 | ribosomal large subunit biogenesis (GO:0042273) | 2.47268485 |
93 | intracellular protein transmembrane import (GO:0044743) | 2.47166933 |
94 | tRNA metabolic process (GO:0006399) | 2.46517384 |
95 | DNA deamination (GO:0045006) | 2.46205027 |
96 | histone H2A acetylation (GO:0043968) | 2.45850699 |
97 | DNA-templated transcription, termination (GO:0006353) | 2.45046888 |
98 | mannosylation (GO:0097502) | 2.44801547 |
99 | regulation of alternative mRNA splicing, via spliceosome (GO:0000381) | 2.44575589 |
100 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.44066640 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.49309391 |
2 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.09722168 |
3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.62074750 |
4 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.28589299 |
5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.91404287 |
6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.83208340 |
7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.76709646 |
8 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.73797111 |
9 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.57846683 |
10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.56519631 |
11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.54052744 |
12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.49298401 |
13 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.40056967 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.38546237 |
15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.36640880 |
16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.24602975 |
17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.24333321 |
18 | FUS_26573619_Chip-Seq_HEK293_Human | 2.23871430 |
19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.23489744 |
20 | EWS_26573619_Chip-Seq_HEK293_Human | 2.22668663 |
21 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.11452970 |
22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97923494 |
23 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.97470124 |
24 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.95831976 |
25 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.91130200 |
26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.88241884 |
27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.81437295 |
28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.80191349 |
29 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.79033607 |
30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.76494435 |
31 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.74500448 |
32 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.72457738 |
33 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.69392732 |
34 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.64677988 |
35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.61717517 |
36 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.59838020 |
37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.58929510 |
38 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.57475337 |
39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.56410728 |
40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.53246550 |
41 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.51896921 |
42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.50751785 |
43 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.50735206 |
44 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.50285035 |
45 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.49143771 |
46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.44636457 |
47 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.42105844 |
48 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.41974790 |
49 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.41513292 |
50 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.39875965 |
51 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.39463638 |
52 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.35081340 |
53 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.31421346 |
54 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.31318880 |
55 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.28726977 |
56 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.27528546 |
57 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.27450767 |
58 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.27056466 |
59 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.24614328 |
60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.23711574 |
61 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23376104 |
62 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22961264 |
63 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.22822499 |
64 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.20520156 |
65 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.19236245 |
66 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.17943666 |
67 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.14552816 |
68 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.13329658 |
69 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12581060 |
70 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.09564693 |
71 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.09350081 |
72 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.09324869 |
73 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07783575 |
74 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.05952793 |
75 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.05393624 |
76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.05393624 |
77 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.05007343 |
78 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.04572930 |
79 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.04554442 |
80 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.03405734 |
81 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.03405734 |
82 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.03019116 |
83 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.02505317 |
84 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.02312584 |
85 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.01672521 |
86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.97554933 |
87 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.96865041 |
88 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.96399756 |
89 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.94982964 |
90 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.94978751 |
91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.94463136 |
92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.93360793 |
93 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.93327773 |
94 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.91389456 |
95 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.89748542 |
96 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.89621130 |
97 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.89395035 |
98 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.88652267 |
99 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.87919198 |
100 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.86795090 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002102_abnormal_ear_morphology | 3.07547288 |
2 | MP0008877_abnormal_DNA_methylation | 3.01085704 |
3 | MP0003880_abnormal_central_pattern | 2.93808373 |
4 | MP0008058_abnormal_DNA_repair | 2.80534062 |
5 | MP0006292_abnormal_olfactory_placode | 2.52894232 |
6 | MP0001529_abnormal_vocalization | 2.52258953 |
7 | MP0003787_abnormal_imprinting | 2.52236643 |
8 | MP0003890_abnormal_embryonic-extraembry | 2.09260670 |
9 | MP0003693_abnormal_embryo_hatching | 2.07746882 |
10 | MP0006072_abnormal_retinal_apoptosis | 2.01742800 |
11 | MP0009046_muscle_twitch | 1.99795255 |
12 | MP0002638_abnormal_pupillary_reflex | 1.94940443 |
13 | MP0003121_genomic_imprinting | 1.91659649 |
14 | MP0002736_abnormal_nociception_after | 1.89812061 |
15 | MP0006276_abnormal_autonomic_nervous | 1.82839869 |
16 | MP0001188_hyperpigmentation | 1.74978073 |
17 | MP0002938_white_spotting | 1.73533980 |
18 | MP0005084_abnormal_gallbladder_morpholo | 1.71513588 |
19 | MP0010094_abnormal_chromosome_stability | 1.70830134 |
20 | MP0000372_irregular_coat_pigmentation | 1.69396784 |
21 | MP0003122_maternal_imprinting | 1.69387573 |
22 | MP0009745_abnormal_behavioral_response | 1.66772566 |
23 | MP0005551_abnormal_eye_electrophysiolog | 1.65264065 |
24 | MP0000569_abnormal_digit_pigmentation | 1.61912383 |
25 | MP0001984_abnormal_olfaction | 1.60546190 |
26 | MP0006035_abnormal_mitochondrial_morpho | 1.60426842 |
27 | MP0004142_abnormal_muscle_tone | 1.60080593 |
28 | MP0003011_delayed_dark_adaptation | 1.58930582 |
29 | MP0002277_abnormal_respiratory_mucosa | 1.55286139 |
30 | MP0002272_abnormal_nervous_system | 1.54640478 |
31 | MP0001968_abnormal_touch/_nociception | 1.54235721 |
32 | MP0002837_dystrophic_cardiac_calcinosis | 1.52564656 |
33 | MP0001293_anophthalmia | 1.50435350 |
34 | MP0005253_abnormal_eye_physiology | 1.50376689 |
35 | MP0000778_abnormal_nervous_system | 1.47829299 |
36 | MP0003718_maternal_effect | 1.45041042 |
37 | MP0008789_abnormal_olfactory_epithelium | 1.42492220 |
38 | MP0008995_early_reproductive_senescence | 1.41690229 |
39 | MP0004147_increased_porphyrin_level | 1.41456511 |
40 | MP0006036_abnormal_mitochondrial_physio | 1.39144270 |
41 | MP0003136_yellow_coat_color | 1.37573883 |
42 | MP0004957_abnormal_blastocyst_morpholog | 1.37048352 |
43 | MP0008932_abnormal_embryonic_tissue | 1.34756603 |
44 | MP0001764_abnormal_homeostasis | 1.32676412 |
45 | MP0003786_premature_aging | 1.32006498 |
46 | MP0004859_abnormal_synaptic_plasticity | 1.31701521 |
47 | MP0004133_heterotaxia | 1.30288217 |
48 | MP0000049_abnormal_middle_ear | 1.30167647 |
49 | MP0005394_taste/olfaction_phenotype | 1.30112632 |
50 | MP0005499_abnormal_olfactory_system | 1.30112632 |
51 | MP0001485_abnormal_pinna_reflex | 1.27304487 |
52 | MP0003186_abnormal_redox_activity | 1.26462923 |
53 | MP0009697_abnormal_copulation | 1.26087063 |
54 | MP0002653_abnormal_ependyma_morphology | 1.24956223 |
55 | MP0000631_abnormal_neuroendocrine_gland | 1.24654143 |
56 | MP0001905_abnormal_dopamine_level | 1.23832167 |
57 | MP0002064_seizures | 1.23808885 |
58 | MP0001486_abnormal_startle_reflex | 1.23700435 |
59 | MP0002735_abnormal_chemical_nociception | 1.23553439 |
60 | MP0002572_abnormal_emotion/affect_behav | 1.22516114 |
61 | MP0008007_abnormal_cellular_replicative | 1.22281940 |
62 | MP0003111_abnormal_nucleus_morphology | 1.21635624 |
63 | MP0005423_abnormal_somatic_nervous | 1.19839314 |
64 | MP0003635_abnormal_synaptic_transmissio | 1.19523873 |
65 | MP0003937_abnormal_limbs/digits/tail_de | 1.18539066 |
66 | MP0003077_abnormal_cell_cycle | 1.18177736 |
67 | MP0003567_abnormal_fetal_cardiomyocyte | 1.17861534 |
68 | MP0005187_abnormal_penis_morphology | 1.10904555 |
69 | MP0002557_abnormal_social/conspecific_i | 1.08755197 |
70 | MP0003195_calcinosis | 1.08229010 |
71 | MP0004924_abnormal_behavior | 1.07654546 |
72 | MP0005386_behavior/neurological_phenoty | 1.07654546 |
73 | MP0002734_abnormal_mechanical_nocicepti | 1.06214750 |
74 | MP0002090_abnormal_vision | 1.05905784 |
75 | MP0002160_abnormal_reproductive_system | 1.05471291 |
76 | MP0000647_abnormal_sebaceous_gland | 1.05266022 |
77 | MP0002067_abnormal_sensory_capabilities | 1.04052403 |
78 | MP0002063_abnormal_learning/memory/cond | 1.03537598 |
79 | MP0000516_abnormal_urinary_system | 1.02055057 |
80 | MP0005367_renal/urinary_system_phenotyp | 1.02055057 |
81 | MP0002751_abnormal_autonomic_nervous | 1.01403685 |
82 | MP0008872_abnormal_physiological_respon | 0.99356149 |
83 | MP0001986_abnormal_taste_sensitivity | 0.99206359 |
84 | MP0002210_abnormal_sex_determination | 0.98844289 |
85 | MP0002233_abnormal_nose_morphology | 0.98153577 |
86 | MP0003221_abnormal_cardiomyocyte_apopto | 0.97433084 |
87 | MP0002752_abnormal_somatic_nervous | 0.97001154 |
88 | MP0001286_abnormal_eye_development | 0.96905847 |
89 | MP0004215_abnormal_myocardial_fiber | 0.94564937 |
90 | MP0004270_analgesia | 0.93647934 |
91 | MP0002184_abnormal_innervation | 0.93494180 |
92 | MP0000955_abnormal_spinal_cord | 0.92714987 |
93 | MP0004811_abnormal_neuron_physiology | 0.92400556 |
94 | MP0002095_abnormal_skin_pigmentation | 0.92110219 |
95 | MP0003119_abnormal_digestive_system | 0.90620457 |
96 | MP0005645_abnormal_hypothalamus_physiol | 0.90560446 |
97 | MP0001929_abnormal_gametogenesis | 0.90058486 |
98 | MP0005195_abnormal_posterior_eye | 0.84826009 |
99 | MP0005646_abnormal_pituitary_gland | 0.83083158 |
100 | MP0000653_abnormal_sex_gland | 0.83068036 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.39952278 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.89884412 |
3 | Progressive macrocephaly (HP:0004481) | 3.80210184 |
4 | Acute encephalopathy (HP:0006846) | 3.71012873 |
5 | Mitochondrial inheritance (HP:0001427) | 3.68032018 |
6 | Increased CSF lactate (HP:0002490) | 3.51829167 |
7 | Hepatocellular necrosis (HP:0001404) | 3.23145996 |
8 | Pancreatic cysts (HP:0001737) | 3.21974485 |
9 | Abnormality of the labia minora (HP:0012880) | 3.16836757 |
10 | Increased hepatocellular lipid droplets (HP:0006565) | 2.93154271 |
11 | Pancreatic fibrosis (HP:0100732) | 2.91937719 |
12 | Hepatic necrosis (HP:0002605) | 2.89446363 |
13 | Molar tooth sign on MRI (HP:0002419) | 2.80156647 |
14 | Abnormality of midbrain morphology (HP:0002418) | 2.80156647 |
15 | 3-Methylglutaconic aciduria (HP:0003535) | 2.77332785 |
16 | Abnormality of alanine metabolism (HP:0010916) | 2.76716984 |
17 | Hyperalaninemia (HP:0003348) | 2.76716984 |
18 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.76716984 |
19 | Lipid accumulation in hepatocytes (HP:0006561) | 2.75621003 |
20 | Cerebral edema (HP:0002181) | 2.73599683 |
21 | True hermaphroditism (HP:0010459) | 2.71328615 |
22 | Medial flaring of the eyebrow (HP:0010747) | 2.63631559 |
23 | Methylmalonic acidemia (HP:0002912) | 2.56464545 |
24 | Increased serum lactate (HP:0002151) | 2.55951020 |
25 | Colon cancer (HP:0003003) | 2.55746626 |
26 | Nephronophthisis (HP:0000090) | 2.45677579 |
27 | Renal Fanconi syndrome (HP:0001994) | 2.43567805 |
28 | Lactic acidosis (HP:0003128) | 2.36457069 |
29 | Type II lissencephaly (HP:0007260) | 2.23827202 |
30 | Optic disc pallor (HP:0000543) | 2.21466001 |
31 | Limb dystonia (HP:0002451) | 2.20165452 |
32 | Leukodystrophy (HP:0002415) | 2.18939506 |
33 | Gait imbalance (HP:0002141) | 2.18152912 |
34 | Methylmalonic aciduria (HP:0012120) | 2.12866935 |
35 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.12265358 |
36 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.12265358 |
37 | Pendular nystagmus (HP:0012043) | 2.12261312 |
38 | Optic nerve hypoplasia (HP:0000609) | 2.11298811 |
39 | Congenital primary aphakia (HP:0007707) | 2.10024973 |
40 | Lissencephaly (HP:0001339) | 2.09355240 |
41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.07401845 |
42 | Nephrogenic diabetes insipidus (HP:0009806) | 2.05557523 |
43 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.04989606 |
44 | Intestinal atresia (HP:0011100) | 2.02146678 |
45 | Respiratory failure (HP:0002878) | 2.01940892 |
46 | Focal motor seizures (HP:0011153) | 2.00237421 |
47 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.99400051 |
48 | Increased serum pyruvate (HP:0003542) | 1.95559385 |
49 | Septo-optic dysplasia (HP:0100842) | 1.95093914 |
50 | Meckel diverticulum (HP:0002245) | 1.94583429 |
51 | Broad-based gait (HP:0002136) | 1.94412768 |
52 | Exercise intolerance (HP:0003546) | 1.93364651 |
53 | Chronic hepatic failure (HP:0100626) | 1.92702345 |
54 | Inability to walk (HP:0002540) | 1.92308326 |
55 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.92281955 |
56 | Cerebellar dysplasia (HP:0007033) | 1.91944857 |
57 | Abnormal hair whorl (HP:0010721) | 1.91826674 |
58 | Drooling (HP:0002307) | 1.91109632 |
59 | Myokymia (HP:0002411) | 1.90668149 |
60 | Abnormality of the ileum (HP:0001549) | 1.90139539 |
61 | Short tibia (HP:0005736) | 1.90012061 |
62 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.89213329 |
63 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.89213329 |
64 | Abnormal protein glycosylation (HP:0012346) | 1.89213329 |
65 | Abnormal glycosylation (HP:0012345) | 1.89213329 |
66 | Degeneration of anterior horn cells (HP:0002398) | 1.88599323 |
67 | Abnormality of the anterior horn cell (HP:0006802) | 1.88599323 |
68 | Abnormality of the renal medulla (HP:0100957) | 1.88138635 |
69 | Abnormality of the pons (HP:0007361) | 1.86926053 |
70 | Sclerocornea (HP:0000647) | 1.86856804 |
71 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.85532755 |
72 | CNS demyelination (HP:0007305) | 1.85188827 |
73 | Cerebral hypomyelination (HP:0006808) | 1.84818482 |
74 | X-linked dominant inheritance (HP:0001423) | 1.84289517 |
75 | Birth length less than 3rd percentile (HP:0003561) | 1.83955890 |
76 | Genital tract atresia (HP:0001827) | 1.83381182 |
77 | Type I transferrin isoform profile (HP:0003642) | 1.82748673 |
78 | Hypoplasia of the pons (HP:0012110) | 1.82136222 |
79 | Polyphagia (HP:0002591) | 1.81217863 |
80 | Abnormal lung lobation (HP:0002101) | 1.80289105 |
81 | Increased intramyocellular lipid droplets (HP:0012240) | 1.77870042 |
82 | Progressive inability to walk (HP:0002505) | 1.77683663 |
83 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.76956356 |
84 | Abnormality of serum amino acid levels (HP:0003112) | 1.76683452 |
85 | Hyperglycinemia (HP:0002154) | 1.76628317 |
86 | Vaginal atresia (HP:0000148) | 1.76487910 |
87 | Exertional dyspnea (HP:0002875) | 1.76341904 |
88 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.74838166 |
89 | Abnormal number of erythroid precursors (HP:0012131) | 1.74576633 |
90 | Volvulus (HP:0002580) | 1.73155883 |
91 | Lethargy (HP:0001254) | 1.73045125 |
92 | Atonic seizures (HP:0010819) | 1.72899096 |
93 | Anencephaly (HP:0002323) | 1.71821498 |
94 | Postnatal microcephaly (HP:0005484) | 1.71208838 |
95 | Abnormality of glycolysis (HP:0004366) | 1.69430048 |
96 | Febrile seizures (HP:0002373) | 1.68902330 |
97 | Poor suck (HP:0002033) | 1.67167285 |
98 | Small hand (HP:0200055) | 1.67034757 |
99 | Excessive salivation (HP:0003781) | 1.67025196 |
100 | Retinal dysplasia (HP:0007973) | 1.66247776 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIM28 | 3.37023286 |
2 | SRPK1 | 2.55452581 |
3 | BUB1 | 2.54678955 |
4 | ZAK | 2.35005143 |
5 | BCR | 2.32295952 |
6 | WNK3 | 2.32045428 |
7 | MAP4K2 | 2.18404643 |
8 | CASK | 2.11127702 |
9 | FRK | 2.02263224 |
10 | NUAK1 | 2.01592105 |
11 | MAP3K4 | 1.99165067 |
12 | MKNK2 | 1.99135172 |
13 | BMPR1B | 1.98447927 |
14 | VRK2 | 1.94644511 |
15 | TSSK6 | 1.94092944 |
16 | MST4 | 1.88561731 |
17 | MAP2K7 | 1.85766532 |
18 | PLK4 | 1.84725575 |
19 | EIF2AK3 | 1.78137378 |
20 | PLK3 | 1.73575708 |
21 | STK16 | 1.73359833 |
22 | PBK | 1.72600872 |
23 | TNIK | 1.65235679 |
24 | DYRK2 | 1.64797762 |
25 | VRK1 | 1.60806448 |
26 | PNCK | 1.59411809 |
27 | MAPK13 | 1.59076806 |
28 | MKNK1 | 1.55688330 |
29 | ERBB3 | 1.53522446 |
30 | DYRK3 | 1.47633853 |
31 | BRSK2 | 1.46614401 |
32 | NEK1 | 1.43030791 |
33 | WEE1 | 1.35481527 |
34 | BCKDK | 1.35334524 |
35 | MARK1 | 1.35166414 |
36 | NME1 | 1.34470143 |
37 | CSNK1G2 | 1.34281325 |
38 | CSNK1G3 | 1.29363508 |
39 | CSNK1G1 | 1.26663661 |
40 | MINK1 | 1.26557658 |
41 | ADRBK2 | 1.25987340 |
42 | PLK2 | 1.23621205 |
43 | PDK2 | 1.22373503 |
44 | EIF2AK1 | 1.21682805 |
45 | CDC7 | 1.09140837 |
46 | CSNK1A1L | 1.04001868 |
47 | EPHA4 | 1.03507687 |
48 | ACVR1B | 1.03286035 |
49 | TTK | 1.00437627 |
50 | SIK3 | 0.98181697 |
51 | CDK19 | 0.97467200 |
52 | PLK1 | 0.96283440 |
53 | PINK1 | 0.93873419 |
54 | PRKCG | 0.90645716 |
55 | GRK1 | 0.90510473 |
56 | OXSR1 | 0.83036081 |
57 | RPS6KA4 | 0.81731776 |
58 | PAK3 | 0.80707703 |
59 | TLK1 | 0.77298999 |
60 | TAF1 | 0.74177549 |
61 | ATR | 0.68382005 |
62 | BRSK1 | 0.67196055 |
63 | PRKCE | 0.62953323 |
64 | STK38L | 0.61670692 |
65 | EIF2AK2 | 0.60996663 |
66 | LIMK1 | 0.59960342 |
67 | DYRK1A | 0.58980373 |
68 | CHEK2 | 0.56804757 |
69 | CCNB1 | 0.55454416 |
70 | RPS6KA5 | 0.54974392 |
71 | NTRK2 | 0.53554274 |
72 | UHMK1 | 0.52386347 |
73 | MAP3K5 | 0.51563554 |
74 | MAP3K12 | 0.51517346 |
75 | CAMK2A | 0.49899556 |
76 | NTRK3 | 0.49356739 |
77 | CSNK2A1 | 0.46784744 |
78 | CDK3 | 0.46176739 |
79 | ADRBK1 | 0.45257687 |
80 | PKN1 | 0.45108939 |
81 | AURKB | 0.44582857 |
82 | ATM | 0.44447366 |
83 | MAP2K4 | 0.43711955 |
84 | CSNK1E | 0.41449747 |
85 | WNK4 | 0.41155184 |
86 | CAMKK2 | 0.40241806 |
87 | KSR1 | 0.39453334 |
88 | STK3 | 0.38023907 |
89 | CSNK2A2 | 0.37823816 |
90 | CSNK1A1 | 0.35735579 |
91 | FGFR1 | 0.35598341 |
92 | INSRR | 0.34474633 |
93 | STK39 | 0.33205436 |
94 | GRK5 | 0.32540160 |
95 | MAP3K9 | 0.31522558 |
96 | CDK14 | 0.31368027 |
97 | PIM2 | 0.30245659 |
98 | GRK7 | 0.28924573 |
99 | CDK18 | 0.28160601 |
100 | DAPK2 | 0.27911954 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.82655832 |
2 | Proteasome_Homo sapiens_hsa03050 | 3.68025545 |
3 | Protein export_Homo sapiens_hsa03060 | 3.40928169 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.37465958 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.10426707 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.57569788 |
7 | Basal transcription factors_Homo sapiens_hsa03022 | 2.49972224 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.38331655 |
9 | Ribosome_Homo sapiens_hsa03010 | 2.34840504 |
10 | Mismatch repair_Homo sapiens_hsa03430 | 2.23247198 |
11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.10232824 |
12 | Homologous recombination_Homo sapiens_hsa03440 | 2.07797157 |
13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.97176840 |
14 | Spliceosome_Homo sapiens_hsa03040 | 1.89941975 |
15 | RNA degradation_Homo sapiens_hsa03018 | 1.87742025 |
16 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.85948871 |
17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.81600819 |
18 | Nicotine addiction_Homo sapiens_hsa05033 | 1.78825690 |
19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.72226970 |
20 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.70691037 |
21 | RNA transport_Homo sapiens_hsa03013 | 1.69489272 |
22 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.69354791 |
23 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.68875647 |
24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.67466401 |
25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.67275631 |
26 | DNA replication_Homo sapiens_hsa03030 | 1.59290152 |
27 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.55116619 |
28 | Phototransduction_Homo sapiens_hsa04744 | 1.50251866 |
29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.46104865 |
30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.45733729 |
31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.41508386 |
32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.39152552 |
33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.38958037 |
34 | Base excision repair_Homo sapiens_hsa03410 | 1.30600649 |
35 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.20147544 |
36 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.17974672 |
37 | Purine metabolism_Homo sapiens_hsa00230 | 1.15204915 |
38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.13078326 |
39 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.12300254 |
40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.09053400 |
41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.08597186 |
42 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.05866744 |
43 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.03390877 |
44 | GABAergic synapse_Homo sapiens_hsa04727 | 0.95618825 |
45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.94606784 |
46 | Cell cycle_Homo sapiens_hsa04110 | 0.93756302 |
47 | Circadian rhythm_Homo sapiens_hsa04710 | 0.93712744 |
48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.93625543 |
49 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.92925337 |
50 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.90965804 |
51 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.90666502 |
52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.89053602 |
53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87507681 |
54 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.85295450 |
55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.82015355 |
56 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.81754202 |
57 | Taste transduction_Homo sapiens_hsa04742 | 0.81694741 |
58 | Morphine addiction_Homo sapiens_hsa05032 | 0.78108927 |
59 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.78077430 |
60 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.73791308 |
61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72966917 |
62 | Peroxisome_Homo sapiens_hsa04146 | 0.71707522 |
63 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.71003710 |
64 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.67969175 |
65 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.67491394 |
66 | Sulfur relay system_Homo sapiens_hsa04122 | 0.65615839 |
67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.65577686 |
68 | Olfactory transduction_Homo sapiens_hsa04740 | 0.62575475 |
69 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.60531607 |
70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.54218044 |
71 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.52462568 |
72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49616406 |
73 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47688261 |
74 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.46108367 |
75 | Alcoholism_Homo sapiens_hsa05034 | 0.45639909 |
76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45297193 |
77 | Circadian entrainment_Homo sapiens_hsa04713 | 0.43625815 |
78 | Cocaine addiction_Homo sapiens_hsa05030 | 0.39957731 |
79 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.39392499 |
80 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.39085114 |
81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.34767637 |
82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.34407487 |
83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32092345 |
84 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.31262058 |
85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.29753092 |
86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.29645260 |
87 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.29592790 |
88 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.28240134 |
89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.26917708 |
90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24469123 |
91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.21858668 |
92 | Carbon metabolism_Homo sapiens_hsa01200 | 0.21819502 |
93 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.21614081 |
94 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.21407974 |
95 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.21308574 |
96 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20313791 |
97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.18647842 |
98 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.17390022 |
99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.16817671 |
100 | Legionellosis_Homo sapiens_hsa05134 | 0.14015892 |