ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.95306695
2	indolalkylamine metabolic process (GO:0006586)	4.09431325
3	response to pheromone (GO:0019236)	4.06294982
4	kynurenine metabolic process (GO:0070189)	4.05531412
5	indole-containing compound catabolic process (GO:0042436)	4.04569271
6	indolalkylamine catabolic process (GO:0046218)	4.04569271
7	tryptophan catabolic process (GO:0006569)	4.04569271
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.90819272
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.84454766
10	L-fucose catabolic process (GO:0042355)	3.81500439
11	fucose catabolic process (GO:0019317)	3.81500439
12	L-fucose metabolic process (GO:0042354)	3.81500439
13	cellular ketone body metabolic process (GO:0046950)	3.49829365
14	nonmotile primary cilium assembly (GO:0035058)	3.48387377
15	tryptophan metabolic process (GO:0006568)	3.42965711
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42268862
17	platelet dense granule organization (GO:0060155)	3.36850105
18	negative regulation of telomere maintenance (GO:0032205)	3.35829902
19	DNA deamination (GO:0045006)	3.31592960
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25346067
21	NADH dehydrogenase complex assembly (GO:0010257)	3.25346067
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25346067
23	indole-containing compound metabolic process (GO:0042430)	3.24256070
24	protein complex biogenesis (GO:0070271)	3.21738089
25	kidney morphogenesis (GO:0060993)	3.16026101
26	ketone body metabolic process (GO:1902224)	3.13335693
27	detection of light stimulus involved in visual perception (GO:0050908)	3.11426083
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.11426083
29	primary amino compound metabolic process (GO:1901160)	3.10712115
30	sulfation (GO:0051923)	3.08631215
31	nephron tubule morphogenesis (GO:0072078)	3.08196413
32	nephron epithelium morphogenesis (GO:0072088)	3.08196413
33	respiratory chain complex IV assembly (GO:0008535)	3.07455788
34	cellular biogenic amine catabolic process (GO:0042402)	3.00656376
35	amine catabolic process (GO:0009310)	3.00656376
36	epithelial cilium movement (GO:0003351)	3.00456727
37	auditory receptor cell stereocilium organization (GO:0060088)	2.97016908
38	protein-cofactor linkage (GO:0018065)	2.92796710
39	regulation of cilium movement (GO:0003352)	2.92638595
40	behavioral response to ethanol (GO:0048149)	2.87790741
41	protein K11-linked deubiquitination (GO:0035871)	2.87253570
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85451319
43	negative regulation of mast cell activation (GO:0033004)	2.82413173
44	aromatic amino acid family catabolic process (GO:0009074)	2.79040852
45	mannosylation (GO:0097502)	2.78839861
46	neural tube formation (GO:0001841)	2.77594884
47	gamma-aminobutyric acid transport (GO:0015812)	2.74455528
48	adult feeding behavior (GO:0008343)	2.74322985
49	cornea development in camera-type eye (GO:0061303)	2.74297971
50	serotonin metabolic process (GO:0042428)	2.74006278
51	neuronal action potential (GO:0019228)	2.71021147
52	axoneme assembly (GO:0035082)	2.70708026
53	reflex (GO:0060004)	2.70498903
54	cytochrome complex assembly (GO:0017004)	2.70128901
55	inner ear receptor stereocilium organization (GO:0060122)	2.70046523
56	cilium organization (GO:0044782)	2.70016936
57	regulation of action potential (GO:0098900)	2.69824273
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.68599987
59	multicellular organism reproduction (GO:0032504)	2.67315987
60	photoreceptor cell maintenance (GO:0045494)	2.67189027
61	replication fork processing (GO:0031297)	2.66970323
62	cilium morphogenesis (GO:0060271)	2.66724979
63	synaptic transmission, cholinergic (GO:0007271)	2.65900103
64	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.64933383
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63710420
66	reciprocal meiotic recombination (GO:0007131)	2.63408899
67	reciprocal DNA recombination (GO:0035825)	2.63408899
68	regulation of glucokinase activity (GO:0033131)	2.62819626
69	regulation of hexokinase activity (GO:1903299)	2.62819626
70	piRNA metabolic process (GO:0034587)	2.62795711
71	C4-dicarboxylate transport (GO:0015740)	2.61194970
72	cilium assembly (GO:0042384)	2.60873031
73	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.58038693
74	photoreceptor cell development (GO:0042461)	2.54335579
75	rhodopsin mediated signaling pathway (GO:0016056)	2.54001611
76	cilium movement (GO:0003341)	2.53583645
77	sulfate transmembrane transport (GO:1902358)	2.53528634
78	benzene-containing compound metabolic process (GO:0042537)	2.52801460
79	neuron fate determination (GO:0048664)	2.52317924
80	protein polyglutamylation (GO:0018095)	2.50581930
81	somite development (GO:0061053)	2.49936963
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46303472
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45380527
84	S-adenosylmethionine metabolic process (GO:0046500)	2.44336944
85	ubiquinone biosynthetic process (GO:0006744)	2.43803584
86	retinal cone cell development (GO:0046549)	2.43443198
87	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.42567980
88	renal tubule morphogenesis (GO:0061333)	2.41715565
89	amino acid salvage (GO:0043102)	2.40324992
90	L-methionine salvage (GO:0071267)	2.40324992
91	L-methionine biosynthetic process (GO:0071265)	2.40324992
92	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.40000191
93	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.39864004
94	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.39864004
95	startle response (GO:0001964)	2.38986982
96	GPI anchor metabolic process (GO:0006505)	2.37163898
97	adaptation of signaling pathway (GO:0023058)	2.36230597
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.35999510
99	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.35638951
100	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.35638951

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60283011
2	VDR_22108803_ChIP-Seq_LS180_Human	3.46995449
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.35024742
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03095547
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65827010
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53596270
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52457611
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41440970
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23253038
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14785035
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14298453
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.12465945
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06669026
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00699934
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99169632
16	EWS_26573619_Chip-Seq_HEK293_Human	1.98911241
17	P300_19829295_ChIP-Seq_ESCs_Human	1.96617778
18	FUS_26573619_Chip-Seq_HEK293_Human	1.95046274
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.83392003
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77853365
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77335011
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75644244
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.67356254
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65651064
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63950688
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.60368516
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56742482
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54558015
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52747360
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.52747360
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51578285
32	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51212222
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50675501
34	STAT3_23295773_ChIP-Seq_U87_Human	1.45889480
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44623944
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44088746
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42252117
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42035015
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41985463
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41879022
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.39787598
42	AR_25329375_ChIP-Seq_VCAP_Human	1.39359196
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39106679
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38385822
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37275802
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35949525
47	TCF4_23295773_ChIP-Seq_U87_Human	1.35817537
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34950700
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34950700
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.34591616
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33056692
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33056692
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31399858
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31399858
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31311919
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29915440
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29171492
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28813431
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.28312524
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27169657
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26978580
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26714699
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26142044
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25985442
65	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.24816557
66	NCOR_22424771_ChIP-Seq_293T_Human	1.24509939
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24265445
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21153727
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20819997
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20066617
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18379107
72	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18244871
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16966026
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16587205
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15332824
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14217510
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13018693
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12783669
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12558808
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11308179
81	AR_20517297_ChIP-Seq_VCAP_Human	1.11170017
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09803799
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08387232
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08037398
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.07021901
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02853291
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02413716
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01326248
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00804787
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00299174
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.00255070
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.99652589
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99646768
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99639795
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98150669
96	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98082865
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97400578
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97212117
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96282350
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96051622

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.87289279
2	MP0003195_calcinosis	2.77511200
3	MP0003787_abnormal_imprinting	2.59451395
4	MP0001968_abnormal_touch/_nociception	2.58536496
5	MP0005646_abnormal_pituitary_gland	2.58287250
6	MP0008877_abnormal_DNA_methylation	2.53136373
7	MP0005551_abnormal_eye_electrophysiolog	2.43905012
8	MP0006292_abnormal_olfactory_placode	2.41509820
9	MP0002736_abnormal_nociception_after	2.37784368
10	MP0003880_abnormal_central_pattern	2.11581869
11	MP0008875_abnormal_xenobiotic_pharmacok	2.08976745
12	MP0002102_abnormal_ear_morphology	2.03159536
13	MP0008872_abnormal_physiological_respon	2.01838813
14	MP0009046_muscle_twitch	2.00093121
15	MP0006276_abnormal_autonomic_nervous	1.95105596
16	MP0006072_abnormal_retinal_apoptosis	1.94393418
17	MP0001986_abnormal_taste_sensitivity	1.90893708
18	MP0004885_abnormal_endolymph	1.81811918
19	MP0000569_abnormal_digit_pigmentation	1.79485864
20	MP0002837_dystrophic_cardiac_calcinosis	1.79318088
21	MP0009745_abnormal_behavioral_response	1.78912517
22	MP0003011_delayed_dark_adaptation	1.77947720
23	MP0005253_abnormal_eye_physiology	1.76798354
24	MP0002272_abnormal_nervous_system	1.76749419
25	MP0002876_abnormal_thyroid_physiology	1.74127684
26	MP0004147_increased_porphyrin_level	1.74110132
27	MP0002638_abnormal_pupillary_reflex	1.73814857
28	MP0002938_white_spotting	1.69477257
29	MP0005084_abnormal_gallbladder_morpholo	1.65755812
30	MP0002653_abnormal_ependyma_morphology	1.62899785
31	MP0001486_abnormal_startle_reflex	1.60954455
32	MP0004142_abnormal_muscle_tone	1.58200618
33	MP0001501_abnormal_sleep_pattern	1.55373807
34	MP0004133_heterotaxia	1.50335612
35	MP0000631_abnormal_neuroendocrine_gland	1.48132024
36	MP0003122_maternal_imprinting	1.45308676
37	MP0001984_abnormal_olfaction	1.43613114
38	MP0002160_abnormal_reproductive_system	1.41745429
39	MP0002557_abnormal_social/conspecific_i	1.41361209
40	MP0000372_irregular_coat_pigmentation	1.39629536
41	MP0005645_abnormal_hypothalamus_physiol	1.37648570
42	MP0002572_abnormal_emotion/affect_behav	1.37434531
43	MP0005174_abnormal_tail_pigmentation	1.35211777
44	MP0002928_abnormal_bile_duct	1.34729860
45	MP0002064_seizures	1.33866985
46	MP0002735_abnormal_chemical_nociception	1.33345723
47	MP0001485_abnormal_pinna_reflex	1.33326326
48	MP0000427_abnormal_hair_cycle	1.32663343
49	MP0003121_genomic_imprinting	1.32596359
50	MP0005085_abnormal_gallbladder_physiolo	1.32515079
51	MP0004043_abnormal_pH_regulation	1.29685135
52	MP0005389_reproductive_system_phenotype	1.23921430
53	MP0001970_abnormal_pain_threshold	1.21186410
54	MP0004742_abnormal_vestibular_system	1.19855311
55	MP0003252_abnormal_bile_duct	1.19279120
56	MP0001529_abnormal_vocalization	1.18366094
57	MP0002733_abnormal_thermal_nociception	1.15196570
58	MP0002063_abnormal_learning/memory/cond	1.11019330
59	MP0002234_abnormal_pharynx_morphology	1.10010165
60	MP0002138_abnormal_hepatobiliary_system	1.09400560
61	MP0001919_abnormal_reproductive_system	1.08582210
62	MP0005386_behavior/neurological_phenoty	1.07254047
63	MP0004924_abnormal_behavior	1.07254047
64	MP0002734_abnormal_mechanical_nocicepti	1.06761670
65	MP0003646_muscle_fatigue	1.06653020
66	MP0010329_abnormal_lipoprotein_level	1.06430832
67	MP0003635_abnormal_synaptic_transmissio	1.05992675
68	MP0008995_early_reproductive_senescence	1.04419081
69	MP0005195_abnormal_posterior_eye	1.03879097
70	MP0005410_abnormal_fertilization	1.01129054
71	MP0002067_abnormal_sensory_capabilities	1.00108237
72	MP0001905_abnormal_dopamine_level	0.99223347
73	MP0002095_abnormal_skin_pigmentation	0.99083514
74	MP0001502_abnormal_circadian_rhythm	0.97609318
75	MP0000026_abnormal_inner_ear	0.96060771
76	MP0010386_abnormal_urinary_bladder	0.95907802
77	MP0008789_abnormal_olfactory_epithelium	0.93187232
78	MP0003119_abnormal_digestive_system	0.90694737
79	MP0009780_abnormal_chondrocyte_physiolo	0.90652970
80	MP0003698_abnormal_male_reproductive	0.90377368
81	MP0005379_endocrine/exocrine_gland_phen	0.89480618
82	MP0008058_abnormal_DNA_repair	0.89211457
83	MP0002752_abnormal_somatic_nervous	0.88367965
84	MP0001764_abnormal_homeostasis	0.87438448
85	MP0000778_abnormal_nervous_system	0.86666053
86	MP0002229_neurodegeneration	0.86537881
87	MP0005365_abnormal_bile_salt	0.86513750
88	MP0001963_abnormal_hearing_physiology	0.86203527
89	MP0001324_abnormal_eye_pigmentation	0.85035366
90	MP0004145_abnormal_muscle_electrophysio	0.83706439
91	MP0000230_abnormal_systemic_arterial	0.83412685
92	MP0003283_abnormal_digestive_organ	0.82977674
93	MP0001929_abnormal_gametogenesis	0.82135606
94	MP0005075_abnormal_melanosome_morpholog	0.82105611
95	MP0005423_abnormal_somatic_nervous	0.79800071
96	MP0005360_urolithiasis	0.78009942
97	MP0002210_abnormal_sex_determination	0.77404406
98	MP0000015_abnormal_ear_pigmentation	0.76956745
99	MP0002909_abnormal_adrenal_gland	0.75289294
100	MP0003718_maternal_effect	0.75137795

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57165512
2	Pancreatic fibrosis (HP:0100732)	4.35283441
3	True hermaphroditism (HP:0010459)	4.34315601
4	Abnormality of midbrain morphology (HP:0002418)	3.88794256
5	Molar tooth sign on MRI (HP:0002419)	3.88794256
6	Type II lissencephaly (HP:0007260)	3.66028638
7	Congenital stationary night blindness (HP:0007642)	3.62583093
8	Nephronophthisis (HP:0000090)	3.45925015
9	Medial flaring of the eyebrow (HP:0010747)	3.30524045
10	Abnormality of the renal cortex (HP:0011035)	3.27519606
11	Attenuation of retinal blood vessels (HP:0007843)	3.17451356
12	Abnormality of the renal medulla (HP:0100957)	3.10762910
13	Pendular nystagmus (HP:0012043)	3.07330781
14	Abolished electroretinogram (ERG) (HP:0000550)	2.92920770
15	Cystic liver disease (HP:0006706)	2.86758369
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.84616984
17	Cerebellar dysplasia (HP:0007033)	2.73308824
18	Hyperventilation (HP:0002883)	2.69556238
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64021883
20	Gait imbalance (HP:0002141)	2.59474339
21	Decreased central vision (HP:0007663)	2.55873973
22	Renal cortical cysts (HP:0000803)	2.55691786
23	Abnormal drinking behavior (HP:0030082)	2.54537753
24	Polydipsia (HP:0001959)	2.54537753
25	Congenital primary aphakia (HP:0007707)	2.50932453
26	Acute necrotizing encephalopathy (HP:0006965)	2.49939952
27	Tubular atrophy (HP:0000092)	2.49875684
28	Lissencephaly (HP:0001339)	2.49296388
29	Sclerocornea (HP:0000647)	2.46885292
30	Chronic hepatic failure (HP:0100626)	2.43579250
31	Mitochondrial inheritance (HP:0001427)	2.43470810
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42327646
33	Increased corneal curvature (HP:0100692)	2.40647758
34	Keratoconus (HP:0000563)	2.40647758
35	Male pseudohermaphroditism (HP:0000037)	2.39164172
36	Nephrogenic diabetes insipidus (HP:0009806)	2.37384732
37	Increased CSF lactate (HP:0002490)	2.33530218
38	Congenital, generalized hypertrichosis (HP:0004540)	2.33226072
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32798803
40	Abnormality of alanine metabolism (HP:0010916)	2.32798803
41	Hyperalaninemia (HP:0003348)	2.32798803
42	Large for gestational age (HP:0001520)	2.30400077
43	Anencephaly (HP:0002323)	2.25091898
44	Progressive macrocephaly (HP:0004481)	2.24029302
45	Congenital hepatic fibrosis (HP:0002612)	2.24011197
46	Acute encephalopathy (HP:0006846)	2.22547707
47	Bile duct proliferation (HP:0001408)	2.18131567
48	Abnormal biliary tract physiology (HP:0012439)	2.18131567
49	Optic disc pallor (HP:0000543)	2.17887660
50	Progressive cerebellar ataxia (HP:0002073)	2.16464975
51	Optic nerve hypoplasia (HP:0000609)	2.15961120
52	Genital tract atresia (HP:0001827)	2.13292219
53	Hypothermia (HP:0002045)	2.13033389
54	Gaze-evoked nystagmus (HP:0000640)	2.12338865
55	Postaxial foot polydactyly (HP:0001830)	2.10182394
56	Polyuria (HP:0000103)	2.09164345
57	Furrowed tongue (HP:0000221)	2.05842315
58	Focal motor seizures (HP:0011153)	2.02828426
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02133255
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01930863
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.01675005
62	Vaginal atresia (HP:0000148)	2.00343842
63	Rib fusion (HP:0000902)	1.99104361
64	Pachygyria (HP:0001302)	1.98999006
65	Thyroid-stimulating hormone excess (HP:0002925)	1.98984307
66	Concave nail (HP:0001598)	1.98753035
67	Hepatocellular necrosis (HP:0001404)	1.96825380
68	Hyperglycinemia (HP:0002154)	1.94865074
69	Hyperglycinuria (HP:0003108)	1.94835308
70	Bony spicule pigmentary retinopathy (HP:0007737)	1.94344967
71	Chorioretinal atrophy (HP:0000533)	1.93706731
72	Hepatic necrosis (HP:0002605)	1.93521620
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91811289
74	Focal seizures (HP:0007359)	1.91801979
75	Genetic anticipation (HP:0003743)	1.91154436
76	3-Methylglutaconic aciduria (HP:0003535)	1.91146349
77	Ketoacidosis (HP:0001993)	1.88598820
78	Poor coordination (HP:0002370)	1.88583984
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87680296
80	Ketosis (HP:0001946)	1.85924814
81	Asplenia (HP:0001746)	1.85899839
82	Abnormality of the pons (HP:0007361)	1.85726419
83	Hypoplasia of the pons (HP:0012110)	1.84960035
84	Dialeptic seizures (HP:0011146)	1.82254008
85	Retinal dysplasia (HP:0007973)	1.81432688
86	Inability to walk (HP:0002540)	1.81423025
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.80705832
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80705832
89	Abnormality of DNA repair (HP:0003254)	1.79757466
90	Hemiparesis (HP:0001269)	1.79617977
91	Constricted visual fields (HP:0001133)	1.79013305
92	Postaxial hand polydactyly (HP:0001162)	1.76893299
93	Methylmalonic acidemia (HP:0002912)	1.76300782
94	Disproportionate short-trunk short stature (HP:0003521)	1.75663648
95	Abnormality of the renal collecting system (HP:0004742)	1.75351934
96	Broad-based gait (HP:0002136)	1.75254207
97	Abnormal urine output (HP:0012590)	1.73190907
98	Lipid accumulation in hepatocytes (HP:0006561)	1.71305607
99	Severe muscular hypotonia (HP:0006829)	1.70814416
100	Colon cancer (HP:0003003)	1.70051670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.28438682
2	ADRBK2	2.94518823
3	GRK1	2.70503490
4	WNK4	2.62759302
5	PINK1	2.54008361
6	BMPR1B	2.52952973
7	MAP4K2	2.51342699
8	INSRR	2.42411878
9	WNK3	2.33880137
10	NUAK1	2.33450996
11	ZAK	2.18550282
12	CASK	2.10695792
13	TLK1	1.97705986
14	TAOK3	1.80859906
15	ACVR1B	1.78722786
16	MARK1	1.74010596
17	STK39	1.70559843
18	MAPK13	1.70410660
19	OXSR1	1.65285237
20	TNIK	1.64617371
21	PAK3	1.62422922
22	TRIM28	1.38309887
23	MAP3K4	1.29081866
24	PNCK	1.26717756
25	EPHA4	1.25600580
26	MAP3K9	1.24662320
27	STK16	1.21204685
28	DAPK2	1.20502046
29	VRK2	1.16078855
30	VRK1	1.08539253
31	FER	1.06688119
32	CAMKK2	1.06531415
33	PRKCG	1.06091537
34	TXK	1.05424751
35	MKNK2	1.03392031
36	ADRBK1	1.03217577
37	PRKCE	1.02848836
38	DYRK2	0.97781378
39	NTRK2	0.96643083
40	PLK2	0.92483909
41	MAPK15	0.86463035
42	AKT3	0.85879647
43	NTRK3	0.84639151
44	FGFR2	0.82231573
45	PHKG2	0.76353866
46	PHKG1	0.76353866
47	MST4	0.75459243
48	TIE1	0.75037979
49	TGFBR1	0.74994322
50	MUSK	0.73610815
51	MAP2K6	0.70507239
52	STK38L	0.70484418
53	CAMK1	0.69014282
54	CSNK1G2	0.67293643
55	MAP2K7	0.65898833
56	CSNK1G1	0.65748675
57	CDK19	0.65291856
58	PIK3CA	0.63340856
59	NME1	0.61401634
60	PRKCI	0.59457590
61	PRKCQ	0.55915635
62	CAMK2A	0.55127259
63	PRKCZ	0.53893192
64	PTK2B	0.53627317
65	STK11	0.53570215
66	CHUK	0.53138164
67	CSNK1A1	0.52758239
68	NLK	0.52743500
69	PRKACA	0.52141764
70	IRAK1	0.51783341
71	CSNK1G3	0.50949686
72	PLK3	0.50929612
73	BCR	0.50367079
74	EIF2AK3	0.50296929
75	TNK2	0.50210187
76	SGK2	0.49333256
77	BCKDK	0.47039249
78	RPS6KA5	0.46912129
79	ERBB3	0.44971523
80	IKBKB	0.44575371
81	PKN1	0.42875240
82	ERBB2	0.42599803
83	PIK3CG	0.41844272
84	MKNK1	0.41822848
85	MAPKAPK3	0.40874831
86	WNK1	0.40212203
87	TEC	0.39930515
88	PRKCA	0.39669181
89	MAP2K2	0.39379587
90	CSNK1A1L	0.38713056
91	MAPKAPK5	0.38565386
92	GRK5	0.37770428
93	CSNK1D	0.36842463
94	PLK4	0.36791688
95	PRKG1	0.36395030
96	OBSCN	0.36376445
97	SGK494	0.35662466
98	SGK223	0.35662466
99	DYRK1A	0.34653548
100	CSNK1E	0.34551852

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.73635793
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.65234798
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59902115
4	Phototransduction_Homo sapiens_hsa04744	2.56199762
5	Butanoate metabolism_Homo sapiens_hsa00650	2.50915809
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.47353926
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44076380
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.25658406
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24881500
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23065457
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.00583945
12	Parkinsons disease_Homo sapiens_hsa05012	1.96806361
13	Protein export_Homo sapiens_hsa03060	1.94168982
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.90515698
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88699425
16	Nicotine addiction_Homo sapiens_hsa05033	1.87451752
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.80411349
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76224890
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.73899932
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.70402327
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.63217040
22	RNA polymerase_Homo sapiens_hsa03020	1.57865248
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56457345
24	Caffeine metabolism_Homo sapiens_hsa00232	1.53002660
25	Homologous recombination_Homo sapiens_hsa03440	1.47995320
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.47596444
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.47417113
28	Propanoate metabolism_Homo sapiens_hsa00640	1.47312202
29	Basal transcription factors_Homo sapiens_hsa03022	1.39126905
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.37573931
31	One carbon pool by folate_Homo sapiens_hsa00670	1.37428662
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36189135
33	Taste transduction_Homo sapiens_hsa04742	1.35624562
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35618090
35	Huntingtons disease_Homo sapiens_hsa05016	1.32444252
36	Peroxisome_Homo sapiens_hsa04146	1.30763792
37	ABC transporters_Homo sapiens_hsa02010	1.30018549
38	Olfactory transduction_Homo sapiens_hsa04740	1.25608280
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25014855
40	Alzheimers disease_Homo sapiens_hsa05010	1.20544162
41	Morphine addiction_Homo sapiens_hsa05032	1.18187280
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16912561
43	Insulin secretion_Homo sapiens_hsa04911	1.14614509
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10733569
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10619322
46	Retinol metabolism_Homo sapiens_hsa00830	1.09059425
47	Fat digestion and absorption_Homo sapiens_hsa04975	1.01130649
48	GABAergic synapse_Homo sapiens_hsa04727	1.00516472
49	Histidine metabolism_Homo sapiens_hsa00340	0.99842130
50	RNA degradation_Homo sapiens_hsa03018	0.94515318
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92732957
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92064727
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89992078
54	Circadian entrainment_Homo sapiens_hsa04713	0.89835221
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84921827
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83112988
57	Serotonergic synapse_Homo sapiens_hsa04726	0.82746584
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.81907567
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81045473
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81004624
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80461947
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75902994
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75180791
64	Mineral absorption_Homo sapiens_hsa04978	0.74033415
65	Ribosome_Homo sapiens_hsa03010	0.73921594
66	Fatty acid degradation_Homo sapiens_hsa00071	0.73338246
67	Sulfur metabolism_Homo sapiens_hsa00920	0.69065477
68	Salivary secretion_Homo sapiens_hsa04970	0.67569003
69	Metabolic pathways_Homo sapiens_hsa01100	0.67566286
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66885337
71	Proteasome_Homo sapiens_hsa03050	0.66681851
72	Regulation of autophagy_Homo sapiens_hsa04140	0.66293149
73	Cocaine addiction_Homo sapiens_hsa05030	0.61667725
74	Purine metabolism_Homo sapiens_hsa00230	0.59603974
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58778459
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56497693
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56412637
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.56243877
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53194608
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52987558
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.52733547
82	Fatty acid elongation_Homo sapiens_hsa00062	0.52222333
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50783677
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50617643
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.50361633
86	Sulfur relay system_Homo sapiens_hsa04122	0.49070483
87	Amphetamine addiction_Homo sapiens_hsa05031	0.46248677
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.44343293
89	Circadian rhythm_Homo sapiens_hsa04710	0.39791563
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37139269
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.36783014
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35571695
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.34812356
94	Asthma_Homo sapiens_hsa05310	0.34733500
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34499215
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.34109586
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33837089
98	Long-term depression_Homo sapiens_hsa04730	0.31539010
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30311933
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.29486333

C1ORF64

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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