ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water homeostasis (GO:0030104)	9.00198382
2	peptide cross-linking (GO:0018149)	8.72831253
3	hair cycle (GO:0042633)	8.59201577
4	molting cycle (GO:0042303)	8.59201577
5	epidermal cell differentiation (GO:0009913)	8.51715686
6	long-chain fatty acid biosynthetic process (GO:0042759)	8.22283939
7	epidermis development (GO:0008544)	7.44939748
8	linoleic acid metabolic process (GO:0043651)	7.14091486
9	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.84935121
10	lipoxygenase pathway (GO:0019372)	6.63402183
11	intermediate filament organization (GO:0045109)	6.44300289
12	skin morphogenesis (GO:0043589)	6.18687178
13	keratinocyte development (GO:0003334)	5.98898521
14	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.78470945
15	detection of bacterium (GO:0016045)	5.73737017
16	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.71267285
17	gap junction assembly (GO:0016264)	5.57337963
18	detection of other organism (GO:0098543)	5.24592107
19	lateral sprouting from an epithelium (GO:0060601)	4.86286482
20	intermediate filament cytoskeleton organization (GO:0045104)	4.83615268
21	polarized epithelial cell differentiation (GO:0030859)	4.74206870
22	intermediate filament-based process (GO:0045103)	4.68241135
23	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.59309465
24	hemidesmosome assembly (GO:0031581)	4.56044285
25	establishment of planar polarity (GO:0001736)	4.47547591
26	establishment of tissue polarity (GO:0007164)	4.47547591
27	regulation of natural killer cell differentiation (GO:0032823)	4.45482857
28	epithelial cell differentiation involved in prostate gland development (GO:0060742)	4.40765286
29	fatty acid elongation (GO:0030497)	4.40404999
30	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.36047595
31	phosphatidylcholine acyl-chain remodeling (GO:0036151)	4.10860146
32	negative regulation of interferon-gamma production (GO:0032689)	3.98780547
33	regulation of keratinocyte differentiation (GO:0045616)	3.75984035
34	hair follicle morphogenesis (GO:0031069)	3.64761041
35	epithelium development (GO:0060429)	3.64275177
36	surfactant homeostasis (GO:0043129)	3.57940374
37	ceramide biosynthetic process (GO:0046513)	3.54786974
38	phosphatidylserine metabolic process (GO:0006658)	3.44097416
39	ectoderm development (GO:0007398)	3.37139838
40	intestinal epithelial cell development (GO:0060576)	3.23334555
41	negative regulation of keratinocyte proliferation (GO:0010839)	3.22456970
42	chemical homeostasis within a tissue (GO:0048875)	3.21372048
43	one-carbon compound transport (GO:0019755)	3.19676874
44	phospholipid catabolic process (GO:0009395)	3.16676219
45	regulation of glomerular filtration (GO:0003093)	3.12735370
46	endothelium development (GO:0003158)	3.08457204
47	eyelid development in camera-type eye (GO:0061029)	3.06005873
48	polyol transport (GO:0015791)	3.05536236
49	regulation of keratinocyte proliferation (GO:0010837)	3.03607944
50	keratinization (GO:0031424)	24.1123429
51	negative regulation of heart growth (GO:0061117)	2.96734822
52	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.96734822
53	molting cycle process (GO:0022404)	2.95511423
54	hair cycle process (GO:0022405)	2.95511423
55	detection of external biotic stimulus (GO:0098581)	2.92684280
56	positive regulation of epidermal cell differentiation (GO:0045606)	2.82931401
57	regulation of cholesterol homeostasis (GO:2000188)	2.80954544
58	alditol phosphate metabolic process (GO:0052646)	2.80359097
59	regulation of epidermis development (GO:0045682)	2.80028350
60	regulation of neuron projection regeneration (GO:0070570)	2.78941513
61	regulation of axon regeneration (GO:0048679)	2.78941513
62	regulation of epidermal cell differentiation (GO:0045604)	2.72597567
63	skeletal muscle tissue regeneration (GO:0043403)	2.69623123
64	phospholipid efflux (GO:0033700)	2.64104469
65	positive regulation of cholesterol efflux (GO:0010875)	2.63799448
66	positive regulation of epidermis development (GO:0045684)	2.62826472
67	ventricular cardiac muscle cell action potential (GO:0086005)	2.56189397
68	sphingolipid biosynthetic process (GO:0030148)	2.54665711
69	epithelial cell maturation (GO:0002070)	2.54412657
70	regulation of tight junction assembly (GO:2000810)	2.52943497
71	fibrinolysis (GO:0042730)	2.52076499
72	epithelial cell proliferation (GO:0050673)	2.49812241
73	detection of biotic stimulus (GO:0009595)	2.48153068
74	negative regulation of epidermal cell differentiation (GO:0045605)	2.46526529
75	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.45363675
76	adenine nucleotide transport (GO:0051503)	2.41601674
77	purine ribonucleotide transport (GO:0015868)	2.40174885
78	hair follicle development (GO:0001942)	2.40012465
79	cellular component disassembly involved in execution phase of apoptosis (GO:0006921)	2.38380339
80	retinol metabolic process (GO:0042572)	2.38148396
81	phosphatidylglycerol metabolic process (GO:0046471)	2.37952761
82	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.37646303
83	positive regulation of keratinocyte differentiation (GO:0045618)	2.37101056
84	skin development (GO:0043588)	2.36413308
85	renal system process involved in regulation of blood volume (GO:0001977)	2.36165226
86	positive regulation of monocyte chemotaxis (GO:0090026)	2.35910221
87	genitalia morphogenesis (GO:0035112)	2.33119030
88	unsaturated fatty acid biosynthetic process (GO:0006636)	2.32680765
89	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.32098139
90	imidazole-containing compound metabolic process (GO:0052803)	2.31414966
91	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.30935833
92	epithelial cell differentiation (GO:0030855)	2.30616467
93	regulation of heart rate by cardiac conduction (GO:0086091)	2.29494029
94	positive regulation of cholesterol transport (GO:0032376)	2.29008823
95	establishment of skin barrier (GO:0061436)	19.9971331
96	regulation of water loss via skin (GO:0033561)	17.0919762
97	desmosome organization (GO:0002934)	13.9238377
98	keratinocyte differentiation (GO:0030216)	11.0906594
99	multicellular organismal water homeostasis (GO:0050891)	10.8173200
100	keratinocyte proliferation (GO:0043616)	10.1414888

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.94196342
2	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.92181405
3	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.61230451
4	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.47684631
5	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.21400358
6	* TP63_23658742_ChIP-Seq_EP156T_Human	2.20854314
7	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.16951832
8	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.05490003
9	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.05490003
10	RXR_22108803_ChIP-Seq_LS180_Human	2.04699282
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00301141
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.8321437
13	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.89287481
14	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.82018673
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.69076409
16	* TP63_22573176_ChIP-Seq_HFKS_Human	1.66450103
17	EGR1_19032775_ChIP-ChIP_M12_Human	1.66228977
18	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.56043906
19	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.51380614
20	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.48938658
21	ZNF263_19887448_ChIP-Seq_K562_Human	1.32246069
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.31651743
23	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28739200
24	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.28450406
25	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.25948588
26	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.24746868
27	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.22877475
28	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.14074916
29	CJUN_26792858_Chip-Seq_BT549_Human	1.13808454
30	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.12137667
31	* KLF5_25053715_ChIP-Seq_YYC3_Human	1.09428643
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.08794397
33	SOX2_20726797_ChIP-Seq_SW620_Human	1.08391600
34	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07079299
35	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06301044
36	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06301044
37	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.06158067
38	ERG_20517297_ChIP-Seq_VCAP_Human	1.05589023
39	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.05284831
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03509392
41	TP53_18474530_ChIP-ChIP_U2OS_Human	1.03297578
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02778693
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.01927690
44	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.01433201
45	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.98542510
46	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97817477
47	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97807470
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96917311
49	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.96629855
50	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.93002733
51	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92835547
52	* CTCF_27219007_Chip-Seq_Bcells_Human	0.90426348
53	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.90277291
54	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86913248
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85886756
56	ATF3_27146783_Chip-Seq_COLON_Human	0.85016373
57	GATA4_25053715_ChIP-Seq_YYC3_Human	0.83496522
58	TCF4_22108803_ChIP-Seq_LS180_Human	0.80798615
59	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.79092661
60	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.78523687
61	RBPJ_21746931_ChIP-Seq_IB4_Human	0.77654632
62	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.77159890
63	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.77047663
64	TAF2_19829295_ChIP-Seq_ESCs_Human	0.76507740
65	* P53_21459846_ChIP-Seq_SAOS-2_Human	0.76090715
66	GATA6_25053715_ChIP-Seq_YYC3_Human	0.75265512
67	CDX2_22108803_ChIP-Seq_LS180_Human	0.75188323
68	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.74096534
69	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.74068355
70	RACK7_27058665_Chip-Seq_MCF-7_Human	0.73307268
71	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.72226962
72	CLOCK_20551151_ChIP-Seq_293T_Human	0.71895241
73	BCOR_27268052_Chip-Seq_Bcells_Human	0.71414016
74	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.71002015
75	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.70155154
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.70067122
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.68655488
78	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.68552115
79	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.67033626
80	TP53_16413492_ChIP-PET_HCT116_Human	0.66946983
81	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.66900247
82	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.66793748
83	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.66503399
84	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.65663757
85	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.65571731
86	SMC4_20622854_ChIP-Seq_HELA_Human	0.65477462
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.64217763
88	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.63404534
89	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.63183837
90	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.63157219
91	CEBPB_22108803_ChIP-Seq_LS180_Human	0.62857117
92	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.62670016
93	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.62670016
94	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.62263308
95	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.60990271
96	GATA1_22025678_ChIP-Seq_K562_Human	0.60513127
97	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.60059134
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.59937287
99	AR_25329375_ChIP-Seq_VCAP_Human	0.59239707
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.59180405

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	9.73867917
2	MP0005275_abnormal_skin_tensile	7.50865225
3	MP0009379_abnormal_foot_pigmentation	5.70782241
4	MP0005501_abnormal_skin_physiology	5.34055972
5	MP0010234_abnormal_vibrissa_follicle	4.43197231
6	MP0000579_abnormal_nail_morphology	4.23317119
7	MP0001216_abnormal_epidermal_layer	3.23222945
8	MP0001188_hyperpigmentation	3.10678570
9	MP0003453_abnormal_keratinocyte_physiol	3.03712141
10	MP0003941_abnormal_skin_development	2.90243722
11	MP0004381_abnormal_hair_follicle	2.76531227
12	MP0010771_integument_phenotype	2.75737327
13	MP0004947_skin_inflammation	2.74309972
14	MP0000566_synostosis	2.53606247
15	MP0010678_abnormal_skin_adnexa	2.52590551
16	MP0002060_abnormal_skin_morphology	2.51127662
17	MP0000383_abnormal_hair_follicle	2.46038989
18	MP0002098_abnormal_vibrissa_morphology	2.20573677
19	MP0000647_abnormal_sebaceous_gland	2.20402025
20	MP0000377_abnormal_hair_follicle	2.18787990
21	MP0002095_abnormal_skin_pigmentation	2.00717699
22	MP0003705_abnormal_hypodermis_morpholog	1.93808284
23	MP0003191_abnormal_cellular_cholesterol	1.74651724
24	MP0000015_abnormal_ear_pigmentation	1.73847540
25	MP0009931_abnormal_skin_appearance	1.72467399
26	MP0005409_darkened_coat_color	1.70337608
27	MP0005174_abnormal_tail_pigmentation	1.69342505
28	MP0004782_abnormal_surfactant_physiolog	1.69328595
29	MP0003011_delayed_dark_adaptation	1.53251564
30	MP0004885_abnormal_endolymph	1.52601101
31	MP0000467_abnormal_esophagus_morphology	1.51863158
32	MP0001191_abnormal_skin_condition	1.50400721
33	MP0003878_abnormal_ear_physiology	1.46942765
34	MP0005377_hearing/vestibular/ear_phenot	1.46942765
35	MP0000427_abnormal_hair_cycle	1.41076517
36	MP0000367_abnormal_coat/_hair	1.34227681
37	MP0000465_gastrointestinal_hemorrhage	1.18136705
38	MP0003566_abnormal_cell_adhesion	1.12435091
39	MP0001243_abnormal_dermal_layer	0.94157519
40	MP0010352_gastrointestinal_tract_polyps	0.93277449
41	MP0000762_abnormal_tongue_morphology	0.90863593
42	MP0002009_preneoplasia	0.89245786
43	MP0001784_abnormal_fluid_regulation	0.87378453
44	MP0002177_abnormal_outer_ear	0.83914439
45	MP0009384_cardiac_valve_regurgitation	0.83634143
46	MP0001851_eye_inflammation	0.80184604
47	MP0004264_abnormal_extraembryonic_tissu	0.78325531
48	MP0001984_abnormal_olfaction	0.76599141
49	MP0005023_abnormal_wound_healing	0.73405408
50	MP0009053_abnormal_anal_canal	0.73332729
51	MP0005075_abnormal_melanosome_morpholog	0.65236066
52	MP0009780_abnormal_chondrocyte_physiolo	0.60046392
53	MP0010030_abnormal_orbit_morphology	0.56379361
54	MP0003763_abnormal_thymus_physiology	0.51401055
55	MP0001853_heart_inflammation	0.47882282
56	MP0000428_abnormal_craniofacial_morphol	0.47358587
57	MP0001340_abnormal_eyelid_morphology	0.45828103
58	MP0008789_abnormal_olfactory_epithelium	0.45469183
59	MP0005503_abnormal_tendon_morphology	0.45108817
60	MP0002877_abnormal_melanocyte_morpholog	0.44962413
61	MP0003279_aneurysm	0.44412516
62	MP0002234_abnormal_pharynx_morphology	0.42254622
63	MP0003638_abnormal_response/metabolism_	0.39064593
64	MP0001542_abnormal_bone_strength	0.38911275
65	MP0005499_abnormal_olfactory_system	0.36599173
66	MP0005394_taste/olfaction_phenotype	0.36599173
67	MP0004185_abnormal_adipocyte_glucose	0.36066938
68	MP0000462_abnormal_digestive_system	0.34565656
69	MP0000627_abnormal_mammary_gland	0.34161126
70	MP0002111_abnormal_tail_morphology	0.33101563
71	MP0002233_abnormal_nose_morphology	0.32882173
72	MP0002282_abnormal_trachea_morphology	0.28595583
73	MP0009672_abnormal_birth_weight	0.26849085
74	MP0002133_abnormal_respiratory_system	0.26283739
75	MP0005388_respiratory_system_phenotype	0.26283739
76	MP0008004_abnormal_stomach_pH	0.26072797
77	MP0003950_abnormal_plasma_membrane	0.26069188
78	MP0001186_pigmentation_phenotype	0.25574747
79	MP0009333_abnormal_splenocyte_physiolog	0.24221613
80	MP0002138_abnormal_hepatobiliary_system	0.23874102
81	MP0000750_abnormal_muscle_regeneration	0.22537743
82	MP0003300_gastrointestinal_ulcer	0.22219077
83	MP0005508_abnormal_skeleton_morphology	0.21558016
84	MP0001177_atelectasis	0.21464540
85	MP0005197_abnormal_uvea_morphology	0.21369154
86	MP0002166_altered_tumor_susceptibility	0.20317367
87	MP0003315_abnormal_perineum_morphology	0.19824332
88	MP0002006_tumorigenesis	0.19714796
89	MP0001299_abnormal_eye_distance/	0.19510638
90	MP0008438_abnormal_cutaneous_collagen	0.19256176
91	MP0005647_abnormal_sex_gland	0.19255511
92	MP0003755_abnormal_palate_morphology	0.19154921
93	MP0004197_abnormal_fetal_growth/weight/	0.18601792
94	MP0005171_absent_coat_pigmentation	0.18208426
95	MP0000432_abnormal_head_morphology	0.17269330
96	MP0000685_abnormal_immune_system	0.16057783
97	MP0005193_abnormal_anterior_eye	0.15909109
98	MP0008569_lethality_at_weaning	0.15736938
99	MP0005076_abnormal_cell_differentiation	0.14086433
100	MP0003828_pulmonary_edema	0.13259003

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.23972181
2	Abnormality of nail color (HP:0100643)	8.70994610
3	Erythroderma (HP:0001019)	8.05524916
4	Palmoplantar hyperkeratosis (HP:0000972)	7.82127800
5	Congenital ichthyosiform erythroderma (HP:0007431)	7.64070695
6	Palmar hyperkeratosis (HP:0010765)	7.48204120
7	Hypotrichosis (HP:0001006)	7.20839616
8	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.98436138
9	Erythema (HP:0010783)	6.41076568
10	Plantar hyperkeratosis (HP:0007556)	6.39478957
11	Abnormality of the axillary hair (HP:0100134)	6.31149554
12	Abnormality of secondary sexual hair (HP:0009888)	6.31149554
13	Onycholysis (HP:0001806)	6.16008900
14	Alopecia of scalp (HP:0002293)	6.05710918
15	Conjunctival hamartoma (HP:0100780)	5.56418248
16	Thick nail (HP:0001805)	5.47385420
17	Corneal erosion (HP:0200020)	5.15280404
18	Woolly hair (HP:0002224)	4.82056867
19	Parakeratosis (HP:0001036)	4.75844046
20	Palmoplantar keratoderma (HP:0000982)	4.33042543
21	Fragile nails (HP:0001808)	4.24516400
22	Right ventricular cardiomyopathy (HP:0011663)	4.20143985
23	Gangrene (HP:0100758)	4.04575680
24	Hypohidrosis (HP:0000966)	3.74906921
25	Hamartoma of the eye (HP:0010568)	3.71465560
26	Oral leukoplakia (HP:0002745)	3.71046737
27	Ectropion (HP:0000656)	3.56120961
28	Absent eyelashes (HP:0000561)	3.55537754
29	Abnormal blistering of the skin (HP:0008066)	3.41590383
30	Lip pit (HP:0100267)	3.37516944
31	Sparse eyelashes (HP:0000653)	3.36599404
32	Selective tooth agenesis (HP:0001592)	3.27853931
33	Aplasia involving bones of the upper limbs (HP:0009823)	3.26438296
34	Aplasia of the phalanges of the hand (HP:0009802)	3.26438296
35	Aplasia involving bones of the extremities (HP:0009825)	3.26438296
36	Abnormality of the salivary glands (HP:0010286)	3.24190007
37	Nail dystrophy (HP:0008404)	3.16927967
38	Sparse scalp hair (HP:0002209)	3.13600025
39	Eczematoid dermatitis (HP:0000976)	3.06285217
40	Absent hair (HP:0002298)	2.93185841
41	Abnormal hair laboratory examination (HP:0003328)	2.89813855
42	Pili torti (HP:0003777)	2.82529948
43	Slow-growing hair (HP:0002217)	2.81957221
44	Abnormality of hair growth rate (HP:0011363)	2.81957221
45	Pruritus (HP:0000989)	2.77752764
46	Abnormality of the dental root (HP:0006486)	2.72128892
47	Taurodontia (HP:0000679)	2.72128892
48	Abnormality of permanent molar morphology (HP:0011071)	2.72128892
49	Dry hair (HP:0011359)	2.68326837
50	Hypoplastic labia majora (HP:0000059)	2.63885210
51	Abnormality of molar morphology (HP:0011070)	2.56347981
52	Abnormality of molar (HP:0011077)	2.56347981
53	Split foot (HP:0001839)	2.48366981
54	Nasolacrimal duct obstruction (HP:0000579)	2.44792711
55	Abnormality of the dental pulp (HP:0006479)	2.42122242
56	Abnormality of the labia majora (HP:0012881)	2.40116540
57	Hypergammaglobulinemia (HP:0010702)	2.30120745
58	Melanocytic nevus (HP:0000995)	2.29052413
59	Hamartoma (HP:0010566)	2.23169372
60	Blepharitis (HP:0000498)	2.21222406
61	Lack of skin elasticity (HP:0100679)	2.20857473
62	Conical tooth (HP:0000698)	2.13751310
63	Xerostomia (HP:0000217)	2.11402328
64	Natal tooth (HP:0000695)	2.10231243
65	Curly hair (HP:0002212)	2.08831124
66	Milia (HP:0001056)	2.08422345
67	Septate vagina (HP:0001153)	2.08280850
68	Duplicated collecting system (HP:0000081)	2.06060749
69	Follicular hyperkeratosis (HP:0007502)	2.05991144
70	Depressed nasal tip (HP:0000437)	2.01870323
71	Furrowed tongue (HP:0000221)	1.96055629
72	Abnormality of the lacrimal duct (HP:0011481)	1.96017959
73	Short middle phalanx of the 5th finger (HP:0004220)	1.95699852
74	Ridged nail (HP:0001807)	1.90311980
75	Oligodontia (HP:0000677)	1.86211757
76	Hyperhidrosis (HP:0000975)	1.84424231
77	Advanced eruption of teeth (HP:0006288)	1.83873905
78	Brittle hair (HP:0002299)	1.80943092
79	Long nose (HP:0003189)	1.80302357
80	Abnormality of the nasolacrimal system (HP:0000614)	1.77524069
81	Abnormality of the renal collecting system (HP:0004742)	1.75162012
82	Acanthosis nigricans (HP:0000956)	1.68956129
83	Laryngomalacia (HP:0001601)	1.67125527
84	Fine hair (HP:0002213)	1.64314671
85	Dry skin (HP:0000958)	1.63934454
86	Neonatal death (HP:0003811)	1.63305941
87	Pustule (HP:0200039)	1.62918331
88	Dehydration (HP:0001944)	1.62727518
89	Recurrent corneal erosions (HP:0000495)	1.62629002
90	Skin ulcer (HP:0200042)	1.61699433
91	Breast hypoplasia (HP:0003187)	1.61499255
92	Amniotic constriction ring (HP:0009775)	1.56842349
93	Abnormality of placental membranes (HP:0011409)	1.56842349
94	Tetraparesis (HP:0002273)	1.53961371
95	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.53316278
96	Labial hypoplasia (HP:0000066)	1.53106203
97	Autoamputation (HP:0001218)	1.51912386
98	Ventricular tachycardia (HP:0004756)	1.51754529
99	Non-midline cleft lip (HP:0100335)	1.50899017
100	Anonychia (HP:0001798)	1.48464842

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK24	7.17999602
2	TGFBR1	5.71285696
3	EEF2K	4.33900444
4	MAP3K6	3.66592165
5	MAPKAPK3	3.64372942
6	FGFR1	3.33009023
7	MAPK7	2.80705528
8	FER	2.70722110
9	MAPK12	2.67421158
10	MAP3K2	2.35112489
11	FGFR3	2.11253008
12	TRPM7	1.95406599
13	SGK494	1.92942242
14	SGK223	1.92942242
15	PIK3CG	1.86700988
16	STK3	1.81640258
17	MAP3K3	1.81202102
18	FGFR2	1.75506047
19	MAPKAPK5	1.58761443
20	FRK	1.53304616
21	RIPK1	1.37117120
22	MAP3K9	1.26206476
23	KIT	1.24834130
24	LATS1	1.23660629
25	ERN1	1.21606893
26	EPHA3	1.20694610
27	RPS6KB2	1.20674467
28	NLK	1.15933101
29	RPS6KB1	1.09682329
30	MST1R	1.09669822
31	MAP2K6	1.04349563
32	DMPK	1.01894948
33	EPHA2	1.00567577
34	TGFBR2	0.97581334
35	PRKCE	0.93979413
36	MAP3K1	0.93921342
37	MAP3K7	0.93855673
38	IKBKB	0.93774236
39	IRAK1	0.84066893
40	SGK2	0.84011524
41	GRK6	0.78762129
42	MET	0.73492259
43	EPHB1	0.72887123
44	MARK2	0.69668689
45	MAPKAPK2	0.68259157
46	BRD4	0.65415003
47	ADRBK1	0.65245586
48	PRPF4B	0.64691455
49	TAOK3	0.64189488
50	LRRK2	0.63192900
51	MOS	0.63080014
52	PRKAA2	0.62663725
53	ICK	0.60839702
54	TAF1	0.60772703
55	MINK1	0.60665094
56	MAP2K4	0.60612829
57	GSK3A	0.59795570
58	GRK7	0.59287522
59	SGK3	0.58474586
60	PTK2	0.57469293
61	WNK1	0.55771339
62	SGK1	0.55180385
63	CDK12	0.54761840
64	AKT3	0.51343486
65	STK38L	0.51127143
66	BRSK2	0.48873642
67	MTOR	0.44929673
68	LATS2	0.44877790
69	STK10	0.38488575
70	MAPK9	0.34371954
71	CDK3	0.33563609
72	ILK	0.31768090
73	MST4	0.31731346
74	SIK1	0.30811234
75	IGF1R	0.30715208
76	BCR	0.30281729
77	PRKD2	0.29806624
78	IRAK2	0.29159636
79	PRKCG	0.27615329
80	EPHA4	0.26759854
81	TAOK1	0.26501533
82	PBK	0.24844420
83	RPS6KA2	0.23897721
84	RET	0.23469963
85	ABL1	0.22249153
86	PDGFRA	0.21389787
87	FGFR4	0.19685206
88	CDK6	0.19574346
89	CSNK1D	0.18601100
90	TESK1	0.18568525
91	HIPK2	0.18237943
92	STK11	0.16357484
93	PKN1	0.15503294
94	MAPK8	0.14379677
95	CHUK	0.13918302
96	ITK	0.13882322
97	ERBB3	0.13823148
98	PDGFRB	0.13418586
99	JAK3	0.12726166
100	GRK5	0.11762366

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	6.43211978
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.97086991
3	Ether lipid metabolism_Homo sapiens_hsa00565	3.66087170
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.35601130
5	Histidine metabolism_Homo sapiens_hsa00340	2.96735717
6	Sphingolipid metabolism_Homo sapiens_hsa00600	2.62226232
7	Circadian rhythm_Homo sapiens_hsa04710	2.24114923
8	GnRH signaling pathway_Homo sapiens_hsa04912	2.12970590
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.93607717
10	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.88371269
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.82586044
12	Fatty acid elongation_Homo sapiens_hsa00062	1.80716472
13	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.80669387
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.79756518
15	Phototransduction_Homo sapiens_hsa04744	1.71132939
16	Long-term depression_Homo sapiens_hsa04730	1.67683879
17	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.58346264
18	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.57132536
19	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.50710024
20	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.46793065
21	Serotonergic synapse_Homo sapiens_hsa04726	1.41808376
22	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.35675014
23	Choline metabolism in cancer_Homo sapiens_hsa05231	1.35570609
24	Renin secretion_Homo sapiens_hsa04924	1.34059748
25	Ras signaling pathway_Homo sapiens_hsa04014	1.20884546
26	Amoebiasis_Homo sapiens_hsa05146	1.18063344
27	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.06725801
28	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.01309894
29	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.94618408
30	Platelet activation_Homo sapiens_hsa04611	0.93087420
31	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.88669330
32	Retinol metabolism_Homo sapiens_hsa00830	0.88228926
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87532797
34	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86347885
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.86149135
36	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.82316322
37	MicroRNAs in cancer_Homo sapiens_hsa05206	0.82035397
38	Melanogenesis_Homo sapiens_hsa04916	0.79348979
39	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.78863384
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78300838
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.77262654
42	ABC transporters_Homo sapiens_hsa02010	0.76964088
43	Adherens junction_Homo sapiens_hsa04520	0.76156993
44	ECM-receptor interaction_Homo sapiens_hsa04512	0.74806609
45	p53 signaling pathway_Homo sapiens_hsa04115	0.71961461
46	Thyroid cancer_Homo sapiens_hsa05216	0.71039733
47	Glioma_Homo sapiens_hsa05214	0.69508575
48	Pertussis_Homo sapiens_hsa05133	0.68408841
49	Long-term potentiation_Homo sapiens_hsa04720	0.66239694
50	Acute myeloid leukemia_Homo sapiens_hsa05221	0.65178945
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.63613779
52	Gastric acid secretion_Homo sapiens_hsa04971	0.62852219
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62711566
54	Pancreatic secretion_Homo sapiens_hsa04972	0.58710879
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.58315117
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57958354
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55423377
58	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53978656
59	Notch signaling pathway_Homo sapiens_hsa04330	0.52017247
60	Salivary secretion_Homo sapiens_hsa04970	0.51335868
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50223782
62	MAPK signaling pathway_Homo sapiens_hsa04010	0.49983384
63	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.48807724
64	Tuberculosis_Homo sapiens_hsa05152	0.48553195
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.48117897
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.46748061
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46345787
68	Estrogen signaling pathway_Homo sapiens_hsa04915	0.46171593
69	Tight junction_Homo sapiens_hsa04530	0.45845868
70	Endocytosis_Homo sapiens_hsa04144	0.45634204
71	Renal cell carcinoma_Homo sapiens_hsa05211	0.44660850
72	Proteoglycans in cancer_Homo sapiens_hsa05205	0.43740930
73	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.39861888
74	Hepatitis C_Homo sapiens_hsa05160	0.39478437
75	Bladder cancer_Homo sapiens_hsa05219	0.39263932
76	Circadian entrainment_Homo sapiens_hsa04713	0.38872501
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37017762
78	Axon guidance_Homo sapiens_hsa04360	0.36237101
79	Insulin signaling pathway_Homo sapiens_hsa04910	0.35581646
80	Pancreatic cancer_Homo sapiens_hsa05212	0.35273818
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.34995473
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34741324
83	Gap junction_Homo sapiens_hsa04540	0.34434921
84	Pathways in cancer_Homo sapiens_hsa05200	0.34050372
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.33462239
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32625588
87	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.31435413
88	Toxoplasmosis_Homo sapiens_hsa05145	0.30753962
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29327411
90	Arginine biosynthesis_Homo sapiens_hsa00220	0.27933875
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.27853759
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.27697956
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.26743981
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.24454074
95	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.24396963
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.23852476
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.23618403
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.22925919
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22818921
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22653817

C1ORF68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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