ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.19802347
2	regulation of cilium movement (GO:0003352)	8.38039529
3	primary alcohol catabolic process (GO:0034310)	7.33952962
4	left/right axis specification (GO:0070986)	7.32776004
5	ventricular system development (GO:0021591)	7.08138716
6	microtubule bundle formation (GO:0001578)	6.63077462
7	vitamin transmembrane transport (GO:0035461)	6.58524820
8	intraciliary transport (GO:0042073)	6.19535139
9	ethanol metabolic process (GO:0006067)	6.09058075
10	cilium organization (GO:0044782)	6.04400623
11	diterpenoid biosynthetic process (GO:0016102)	5.83435085
12	cilium assembly (GO:0042384)	5.81329306
13	response to xenobiotic stimulus (GO:0009410)	5.52883855
14	tolerance induction (GO:0002507)	5.15831036
15	centriole assembly (GO:0098534)	5.04966352
16	pyrimidine-containing compound transmembrane transport (GO:0072531)	5.04500421
17	one-carbon compound transport (GO:0019755)	4.86574974
18	regulation of microtubule-based movement (GO:0060632)	4.83578668
19	regulation of interleukin-5 production (GO:0032674)	4.82153787
20	protein localization to cilium (GO:0061512)	4.80368223
21	microtubule-based movement (GO:0007018)	4.78960599
22	cellular component assembly involved in morphogenesis (GO:0010927)	4.67844423
23	lung epithelium development (GO:0060428)	4.67119993
24	negative regulation of T cell differentiation in thymus (GO:0033085)	4.54953451
25	ethanol oxidation (GO:0006069)	4.54703223
26	negative regulation of B cell mediated immunity (GO:0002713)	4.48022383
27	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.48022383
28	sperm capacitation (GO:0048240)	4.47815795
29	establishment of apical/basal cell polarity (GO:0035089)	4.39226652
30	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.38757132
31	negative regulation of humoral immune response (GO:0002921)	4.37656072
32	glomerular epithelial cell development (GO:0072310)	4.34958589
33	regulation of interleukin-13 production (GO:0032656)	4.31777167
34	cell projection assembly (GO:0030031)	4.27714131
35	cilium morphogenesis (GO:0060271)	4.20420991
36	positive regulation of tolerance induction (GO:0002645)	4.12417702
37	microtubule depolymerization (GO:0007019)	4.11870140
38	regulation of germinal center formation (GO:0002634)	4.09318052
39	terpenoid biosynthetic process (GO:0016114)	3.97647191
40	retinoic acid metabolic process (GO:0042573)	3.96985804
41	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.81738568
42	establishment of monopolar cell polarity (GO:0061162)	3.81738568
43	lateral ventricle development (GO:0021670)	3.80142889
44	nucleoside diphosphate phosphorylation (GO:0006165)	3.79261518
45	microtubule polymerization or depolymerization (GO:0031109)	3.73397333
46	cytoplasmic microtubule organization (GO:0031122)	3.70800032
47	negative regulation of inclusion body assembly (GO:0090084)	3.46640249
48	exogenous drug catabolic process (GO:0042738)	3.43362157
49	retinal rod cell development (GO:0046548)	3.35836557
50	establishment of planar polarity (GO:0001736)	3.29212878
51	establishment of tissue polarity (GO:0007164)	3.29212878
52	O-glycan processing (GO:0016266)	3.25413495
53	primary alcohol metabolic process (GO:0034308)	3.16984294
54	glutathione derivative metabolic process (GO:1901685)	3.13518655
55	glutathione derivative biosynthetic process (GO:1901687)	3.13518655
56	regulation of tolerance induction (GO:0002643)	3.08682282
57	retinol metabolic process (GO:0042572)	3.05115738
58	positive regulation of smoothened signaling pathway (GO:0045880)	3.00755567
59	axonemal dynein complex assembly (GO:0070286)	21.9061385
60	hydrogen peroxide biosynthetic process (GO:0050665)	2.98373352
61	determination of left/right symmetry (GO:0007368)	2.96092180
62	sperm motility (GO:0030317)	2.94675023
63	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.89065497
64	centriole replication (GO:0007099)	2.85350387
65	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.85146656
66	determination of bilateral symmetry (GO:0009855)	2.83343056
67	lateral sprouting from an epithelium (GO:0060601)	2.81871565
68	aldehyde catabolic process (GO:0046185)	2.80813441
69	microtubule-based process (GO:0007017)	2.80018706
70	multicellular organismal water homeostasis (GO:0050891)	2.79988909
71	specification of symmetry (GO:0009799)	2.76650355
72	carnitine metabolic process (GO:0009437)	2.75588000
73	drug catabolic process (GO:0042737)	2.73738491
74	regulation of microtubule depolymerization (GO:0031114)	2.72770543
75	retinal cone cell development (GO:0046549)	2.65329762
76	apical protein localization (GO:0045176)	2.63923881
77	reactive oxygen species biosynthetic process (GO:1903409)	2.63823146
78	excretion (GO:0007588)	2.61386379
79	hypotonic response (GO:0006971)	2.58839813
80	progesterone metabolic process (GO:0042448)	2.57395413
81	smoothened signaling pathway (GO:0007224)	2.56628838
82	organelle assembly (GO:0070925)	2.56628004
83	phosphatidylcholine biosynthetic process (GO:0006656)	2.51867830
84	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.50530983
85	photoreceptor cell maintenance (GO:0045494)	2.49550577
86	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.47480089
87	regulation of response to osmotic stress (GO:0047484)	2.47137651
88	hydrogen peroxide catabolic process (GO:0042744)	2.46223154
89	heart looping (GO:0001947)	2.43929138
90	regulation of autophagic vacuole assembly (GO:2000785)	2.42904770
91	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.42127395
92	water homeostasis (GO:0030104)	2.39559929
93	sodium ion homeostasis (GO:0055078)	2.36312377
94	protein O-linked glycosylation (GO:0006493)	2.33850063
95	cilium or flagellum-dependent cell motility (GO:0001539)	19.2798357
96	cilium movement (GO:0003341)	16.2828017
97	motile cilium assembly (GO:0044458)	15.2577091
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.1698848
99	epithelial cilium movement (GO:0003351)	13.7115867
100	axoneme assembly (GO:0035082)	10.7508681

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.02566267
2	DROSHA_22980978_ChIP-Seq_HELA_Human	3.46389955
3	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.43302017
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.10533857
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.90775647
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.75728214
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.54728847
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.29572928
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.10687769
10	AHR_22903824_ChIP-Seq_MCF-7_Human	1.93445414
11	STAT1_20625510_ChIP-Seq_HELA_Human	1.81787737
12	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.81189680
13	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.77229924
14	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.74954380
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.73152058
16	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.72497953
17	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.71543341
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.70308692
19	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.68558537
20	VDR_22108803_ChIP-Seq_LS180_Human	1.66886902
21	TP63_23658742_ChIP-Seq_EP156T_Human	1.66117571
22	SMC4_20622854_ChIP-Seq_HELA_Human	1.65409062
23	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62783831
24	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.54809825
25	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.54465477
26	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.52694465
27	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.52173156
28	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51660824
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.47807454
30	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.46888650
31	KLF5_25053715_ChIP-Seq_YYC3_Human	1.46146583
32	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.41816792
33	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.41373939
34	TP63_22573176_ChIP-Seq_HFKS_Human	1.41365489
35	GATA1_19941826_ChIP-Seq_K562_Human	1.41337131
36	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.40456594
37	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.37647227
38	SMRT_27268052_Chip-Seq_Bcells_Human	1.37551765
39	SOX2_20726797_ChIP-Seq_SW620_Human	1.36271469
40	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.33883737
41	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.33309946
42	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.32624147
43	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.32376723
44	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30856662
45	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28919942
46	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27634405
47	* PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.24503946
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23097548
49	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20860042
50	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.20531928
51	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20504190
52	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19237541
53	GATA4_25053715_ChIP-Seq_YYC3_Human	1.18829461
54	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.18586109
55	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.18027581
56	* PHF8_20622853_ChIP-Seq_HELA_Human	1.16233826
57	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15759431
58	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.11913407
59	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.11806478
60	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.11311085
61	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.10825168
62	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07224495
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05996887
64	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05639115
65	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05375111
66	CEBPB_22108803_ChIP-Seq_LS180_Human	1.05013741
67	CTCF_27219007_Chip-Seq_Bcells_Human	1.04978141
68	GATA2_19941826_ChIP-Seq_K562_Human	1.03191666
69	* CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.02908192
70	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.02192331
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01688963
72	* NFYA_21822215_ChIP-Seq_K562_Human	1.00176863
73	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.99748370
74	P68_20966046_ChIP-Seq_HELA_Human	0.99251974
75	* SMAD4_21799915_ChIP-Seq_A2780_Human	0.99016460
76	* GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98071097
77	P300_27268052_Chip-Seq_Bcells_Human	0.94898879
78	TP53_16413492_ChIP-PET_HCT116_Human	0.94060764
79	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94010330
80	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.92862791
81	PHF8_20622854_ChIP-Seq_HELA_Human	0.92675851
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92220853
83	* NFYB_21822215_ChIP-Seq_K562_Human	0.90906425
84	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90355241
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89928782
86	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.88622743
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.88350995
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.88209488
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88096407
90	CREB1_26743006_Chip-Seq_LNCaP_Human	0.87924990
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87887213
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.87800485
93	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.87575084
94	* TBL1_22424771_ChIP-Seq_293T_Human	0.87294909
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87199032
96	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.87128342
97	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86701786
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86106480
99	AR_20517297_ChIP-Seq_VCAP_Human	0.85871732
100	SOX2_21211035_ChIP-Seq_LN229_Human	0.84695695

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	7.18459973
2	MP0008875_abnormal_xenobiotic_pharmacok	7.16740291
3	MP0002132_abnormal_respiratory_system	5.76922201
4	MP0002277_abnormal_respiratory_mucosa	4.07691117
5	MP0005623_abnormal_meninges_morphology	3.97447339
6	MP0001984_abnormal_olfaction	3.85139036
7	MP0004043_abnormal_pH_regulation	3.76197390
8	MP0009780_abnormal_chondrocyte_physiolo	3.53990982
9	MP0004133_heterotaxia	3.29821395
10	MP0008789_abnormal_olfactory_epithelium	2.99927709
11	MP0000383_abnormal_hair_follicle	2.41589741
12	MP0000566_synostosis	2.31729905
13	MP0005377_hearing/vestibular/ear_phenot	2.20873445
14	MP0003878_abnormal_ear_physiology	2.20873445
15	MP0005083_abnormal_biliary_tract	2.12120678
16	MP0002168_other_aberrant_phenotype	2.09569928
17	MP0010678_abnormal_skin_adnexa	2.04727351
18	MP0002282_abnormal_trachea_morphology	1.98538001
19	MP0004019_abnormal_vitamin_homeostasis	1.93613118
20	MP0003656_abnormal_erythrocyte_physiolo	1.91811355
21	MP0001765_abnormal_ion_homeostasis	1.89258457
22	MP0005394_taste/olfaction_phenotype	1.86643655
23	MP0005499_abnormal_olfactory_system	1.86643655
24	MP0002160_abnormal_reproductive_system	1.79422173
25	MP0001346_abnormal_lacrimal_gland	1.77488562
26	MP0000678_abnormal_parathyroid_gland	1.67755025
27	MP0000465_gastrointestinal_hemorrhage	1.45915109
28	MP0005165_increased_susceptibility_to	1.39724223
29	MP0002909_abnormal_adrenal_gland	1.37823665
30	MP0010155_abnormal_intestine_physiology	1.36290433
31	MP0005395_other_phenotype	1.32146961
32	MP0005636_abnormal_mineral_homeostasis	1.27518137
33	MP0002249_abnormal_larynx_morphology	1.22921092
34	MP0005248_abnormal_Harderian_gland	1.21842161
35	MP0003303_peritoneal_inflammation	1.12298060
36	MP0002876_abnormal_thyroid_physiology	1.08919538
37	MP0009379_abnormal_foot_pigmentation	1.03232617
38	MP0002735_abnormal_chemical_nociception	0.97907637
39	MP0010234_abnormal_vibrissa_follicle	0.97480604
40	MP0002734_abnormal_mechanical_nocicepti	0.96932568
41	MP0005365_abnormal_bile_salt	0.93568382
42	MP0009643_abnormal_urine_homeostasis	0.92693285
43	MP0001485_abnormal_pinna_reflex	0.91943285
44	MP0000681_abnormal_thyroid_gland	0.88873709
45	MP0005085_abnormal_gallbladder_physiolo	0.88817590
46	MP0002233_abnormal_nose_morphology	0.88045135
47	MP0003136_yellow_coat_color	0.85477478
48	MP0002136_abnormal_kidney_physiology	0.85223384
49	MP0005164_abnormal_response_to	0.84331722
50	MP0010030_abnormal_orbit_morphology	0.82703937
51	MP0008004_abnormal_stomach_pH	0.82213385
52	MP0005389_reproductive_system_phenotype	0.80001922
53	MP0004883_abnormal_blood_vessel	0.78655851
54	MP0005464_abnormal_platelet_physiology	0.77322324
55	MP0002638_abnormal_pupillary_reflex	0.77187702
56	MP0009765_abnormal_xenobiotic_induced	0.75428494
57	MP0003698_abnormal_male_reproductive	0.73163443
58	MP0004264_abnormal_extraembryonic_tissu	0.72467725
59	MP0009046_muscle_twitch	0.71996284
60	MP0001879_abnormal_lymphatic_vessel	0.71517686
61	MP0001929_abnormal_gametogenesis	0.70875965
62	MP0005310_abnormal_salivary_gland	0.70660245
63	MP0001849_ear_inflammation	0.70410819
64	MP0002405_respiratory_system_inflammati	0.70106654
65	MP0003453_abnormal_keratinocyte_physiol	0.69302157
66	MP0005220_abnormal_exocrine_pancreas	0.67578435
67	MP0002098_abnormal_vibrissa_morphology	0.66691873
68	MP0009763_increased_sensitivity_to	0.65919107
69	MP0003866_abnormal_defecation	0.65785323
70	MP0005408_hypopigmentation	0.62367833
71	MP0005646_abnormal_pituitary_gland	0.60742916
72	MP0005387_immune_system_phenotype	0.59650775
73	MP0001790_abnormal_immune_system	0.59650775
74	MP0005253_abnormal_eye_physiology	0.59169586
75	MP0000858_altered_metastatic_potential	0.57552003
76	MP0001663_abnormal_digestive_system	0.56598471
77	MP0003045_fibrosis	0.56143187
78	MP0003075_altered_response_to	0.55953998
79	MP0000026_abnormal_inner_ear	0.55815694
80	MP0005503_abnormal_tendon_morphology	0.55455137
81	MP0006082_CNS_inflammation	0.54449134
82	MP0001324_abnormal_eye_pigmentation	0.53801354
83	MP0001664_abnormal_digestion	0.53674621
84	MP0003890_abnormal_embryonic-extraembry	0.53458251
85	MP0008872_abnormal_physiological_respon	0.53117703
86	MP0000467_abnormal_esophagus_morphology	0.50804951
87	MP0002139_abnormal_hepatobiliary_system	0.50103994
88	MP0005551_abnormal_eye_electrophysiolog	0.49405707
89	MP0005388_respiratory_system_phenotype	0.48504821
90	MP0002133_abnormal_respiratory_system	0.48504821
91	MP0001293_anophthalmia	0.48213995
92	MP0001970_abnormal_pain_threshold	0.47967707
93	MP0005409_darkened_coat_color	0.47682614
94	MP0002135_abnormal_kidney_morphology	0.45502822
95	MP0001270_distended_abdomen	0.44841875
96	MP0005023_abnormal_wound_healing	0.44536386
97	MP0001944_abnormal_pancreas_morphology	0.43052665
98	MP0002229_neurodegeneration	0.42539462
99	MP0002116_abnormal_craniofacial_bone	0.42190210
100	MP0001502_abnormal_circadian_rhythm	0.41854746

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	7.98174656
2	Bronchiectasis (HP:0002110)	7.48524595
3	Nasal polyposis (HP:0100582)	6.80912370
4	Abnormality of the nasal mucosa (HP:0000433)	5.66140144
5	Bronchitis (HP:0012387)	4.53037215
6	Recurrent sinusitis (HP:0011108)	4.51297502
7	Infertility (HP:0000789)	4.24276866
8	Chronic sinusitis (HP:0011109)	4.08429337
9	Recurrent otitis media (HP:0000403)	3.95326052
10	Male infertility (HP:0003251)	3.89648935
11	Occipital encephalocele (HP:0002085)	3.52287618
12	Pancreatic fibrosis (HP:0100732)	3.38724306
13	True hermaphroditism (HP:0010459)	3.23137927
14	Hyperactive renin-angiotensin system (HP:0000841)	3.06534788
15	Chronic otitis media (HP:0000389)	3.00432264
16	Atelectasis (HP:0100750)	2.96941892
17	Cystic liver disease (HP:0006706)	2.77380319
18	Abnormality of midbrain morphology (HP:0002418)	2.74465444
19	Molar tooth sign on MRI (HP:0002419)	2.74465444
20	Pancreatic cysts (HP:0001737)	2.74125774
21	Chronic hepatic failure (HP:0100626)	2.70650376
22	Nephronophthisis (HP:0000090)	2.65957045
23	Tubulointerstitial nephritis (HP:0001970)	2.35302183
24	Postaxial foot polydactyly (HP:0001830)	2.33245375
25	Recurrent bronchitis (HP:0002837)	2.15755225
26	Abnormality of the renal medulla (HP:0100957)	2.09061199
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5344623
28	Abnormal respiratory motile cilium morphology (HP:0005938)	11.3059099
29	Abnormal respiratory epithelium morphology (HP:0012253)	11.3059099
30	Absent/shortened dynein arms (HP:0200106)	11.2075221
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	11.2075221
32	Abnormal respiratory motile cilium physiology (HP:0012261)	11.1165134
33	Abnormal ciliary motility (HP:0012262)	10.9684064
34	Rhinitis (HP:0012384)	10.1177555
35	Bell-shaped thorax (HP:0001591)	1.99906278
36	Congenital hepatic fibrosis (HP:0002612)	1.99646423
37	Decreased circulating renin level (HP:0003351)	1.94538314
38	Anencephaly (HP:0002323)	1.89230180
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86664469
40	Renal salt wasting (HP:0000127)	1.84505633
41	Male pseudohermaphroditism (HP:0000037)	1.83355685
42	Absent frontal sinuses (HP:0002688)	1.81506662
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79194102
44	Medial flaring of the eyebrow (HP:0010747)	1.76869354
45	Hyperkalemia (HP:0002153)	1.67511137
46	Tubular atrophy (HP:0000092)	1.67011708
47	Asplenia (HP:0001746)	1.66334373
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.64811959
49	Congenital primary aphakia (HP:0007707)	1.64460154
50	Nephropathy (HP:0000112)	1.63631973
51	Gait imbalance (HP:0002141)	1.61419056
52	Oculomotor apraxia (HP:0000657)	1.57496249
53	Furrowed tongue (HP:0000221)	1.56709512
54	Sclerocornea (HP:0000647)	1.53818762
55	Hyperaldosteronism (HP:0000859)	1.53417664
56	Postaxial hand polydactyly (HP:0001162)	1.46267172
57	Nephrogenic diabetes insipidus (HP:0009806)	1.42110766
58	Abnormality of renin-angiotensin system (HP:0000847)	1.39752391
59	Abnormality of chloride homeostasis (HP:0011422)	1.37002213
60	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.36888393
61	Hypokalemic alkalosis (HP:0001949)	1.32115088
62	Median cleft lip (HP:0000161)	1.31678622
63	Tubulointerstitial abnormality (HP:0001969)	1.29918149
64	Cone-rod dystrophy (HP:0000548)	1.27127027
65	Short thorax (HP:0010306)	1.22972123
66	Preaxial hand polydactyly (HP:0001177)	1.21846796
67	Abnormality of the dental root (HP:0006486)	1.15887406
68	Taurodontia (HP:0000679)	1.15887406
69	Abnormality of permanent molar morphology (HP:0011071)	1.15887406
70	Hyponatremia (HP:0002902)	1.14198113
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.14077612
72	Abnormality of the distal phalanges of the toes (HP:0010182)	1.13900743
73	Glucose intolerance (HP:0000833)	1.13087148
74	Decreased central vision (HP:0007663)	1.12646889
75	Stage 5 chronic kidney disease (HP:0003774)	1.12234206
76	Poor coordination (HP:0002370)	1.12110719
77	Fetal akinesia sequence (HP:0001989)	1.11920620
78	Genital tract atresia (HP:0001827)	1.11883574
79	Vaginal atresia (HP:0000148)	1.11508563
80	Bifid scrotum (HP:0000048)	1.11477076
81	Hand muscle atrophy (HP:0009130)	1.10609217
82	Abnormality of the frontal sinuses (HP:0002687)	1.10344265
83	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.08856569
84	Short nail (HP:0001799)	1.07821375
85	Abnormality of molar morphology (HP:0011070)	1.05763995
86	Abnormality of molar (HP:0011077)	1.05763995
87	Abnormality of the dental pulp (HP:0006479)	1.05399527
88	Lip pit (HP:0100267)	1.03785941
89	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.01449534
90	Abnormal drinking behavior (HP:0030082)	0.99452365
91	Polydipsia (HP:0001959)	0.99452365
92	Muscle fiber splitting (HP:0003555)	0.98987839
93	Popliteal pterygium (HP:0009756)	0.98758241
94	Aplasia of the musculature (HP:0100854)	0.98130900
95	Retinitis pigmentosa (HP:0000510)	0.96965291
96	Supernumerary spleens (HP:0009799)	0.96695153
97	Short femoral neck (HP:0100864)	0.96335133
98	Obstructive sleep apnea (HP:0002870)	0.94963508
99	Purpura (HP:0000979)	0.92941129
100	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	0.92601558

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	6.34521122
2	EPHA2	4.74746078
3	MAPKAPK3	2.24793227
4	MAP3K2	2.11725423
5	NME1	2.05797324
6	STK24	2.04259948
7	MAPK15	11.3614256
8	TTK	1.73779875
9	SMG1	1.68099782
10	PTK2B	1.67953435
11	MAP3K3	1.65353039
12	EEF2K	1.63841256
13	BCR	1.63095295
14	CSK	1.58121588
15	RIPK4	1.56798286
16	STK10	1.28870080
17	LRRK2	1.25674053
18	EPHB1	1.20204152
19	PNCK	1.16777677
20	MST1R	1.16025756
21	MAP3K7	1.07490406
22	NEK6	1.06512077
23	TLK1	1.01131970
24	TRPM7	0.99837610
25	EPHA3	0.92900155
26	MARK2	0.91807906
27	ERBB2	0.89569842
28	STK38	0.87200219
29	STK16	0.84995347
30	CAMKK1	0.84361919
31	LATS1	0.80853648
32	PRKCI	0.79671527
33	TBK1	0.78208153
34	TESK1	0.78042179
35	STK38L	0.75492690
36	BRSK2	0.75275854
37	IRAK1	0.62402815
38	NLK	0.56961725
39	MAP3K12	0.56807967
40	PDPK1	0.55562527
41	GRK6	0.54702780
42	ERBB3	0.54690397
43	MYLK	0.54033240
44	ICK	0.53446904
45	PRKCQ	0.52316849
46	TAOK1	0.50283716
47	PRKAA2	0.50006336
48	PRKCD	0.47652073
49	CAMK2G	0.45748598
50	FER	0.43026644
51	AURKA	0.42949670
52	ZAP70	0.41100750
53	HIPK2	0.39858464
54	TYK2	0.38804901
55	SGK1	0.36560100
56	DYRK1B	0.35721620
57	CAMKK2	0.34366883
58	TRIB3	0.34306879
59	LMTK2	0.32852157
60	CDC42BPA	0.32247408
61	ADRBK1	0.31036780
62	INSRR	0.30361910
63	FRK	0.28056503
64	FYN	0.26452141
65	ABL1	0.24140451
66	PRKACA	0.23270270
67	RPS6KB2	0.22785085
68	PRKCA	0.22571524
69	ROCK2	0.22553109
70	RIPK1	0.22107736
71	PAK1	0.21055402
72	TEC	0.20755488
73	OXSR1	0.20584274
74	MAP2K2	0.20387439
75	ROCK1	0.20130933
76	FGFR3	0.19304970
77	BTK	0.19087069
78	PDK1	0.19051483
79	BLK	0.18614443
80	RPS6KA2	0.18403555
81	STK3	0.18308745
82	AKT2	0.17807473
83	PBK	0.17510925
84	MET	0.16871029
85	SGK2	0.16683024
86	ILK	0.16639538
87	GRK1	0.15933905
88	DYRK1A	0.15781888
89	MATK	0.15622728
90	EGFR	0.15296336
91	SRC	0.15289917
92	MAP3K4	0.14576890
93	MAP2K1	0.14408031
94	NEK9	0.14003812
95	BMPR2	0.13975202
96	SGK223	0.13004677
97	SGK494	0.13004677
98	CAMK2A	0.12625039
99	STK11	0.12284880
100	MAPKAPK5	0.11906403

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.62846988
2	Phenylalanine metabolism_Homo sapiens_hsa00360	4.81797676
3	Chemical carcinogenesis_Homo sapiens_hsa05204	4.56963598
4	Histidine metabolism_Homo sapiens_hsa00340	4.52543521
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.39216432
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.82499012
7	beta-Alanine metabolism_Homo sapiens_hsa00410	2.97999681
8	Huntingtons disease_Homo sapiens_hsa05016	2.65264331
9	Glutathione metabolism_Homo sapiens_hsa00480	2.59951526
10	Retinol metabolism_Homo sapiens_hsa00830	2.32838925
11	Caffeine metabolism_Homo sapiens_hsa00232	2.32088410
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.97809917
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97661501
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87079639
15	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.87026282
16	Sphingolipid metabolism_Homo sapiens_hsa00600	1.84859302
17	ABC transporters_Homo sapiens_hsa02010	1.55113951
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.51179743
19	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.51116377
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.51017288
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.44133298
22	Tight junction_Homo sapiens_hsa04530	1.33707495
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17445375
24	Fatty acid degradation_Homo sapiens_hsa00071	1.17005002
25	Salivary secretion_Homo sapiens_hsa04970	1.05782269
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.98674943
27	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.98326646
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93227505
29	Circadian rhythm_Homo sapiens_hsa04710	0.92835770
30	Peroxisome_Homo sapiens_hsa04146	0.92185660
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.87909639
32	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82279115
33	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.80527541
34	Notch signaling pathway_Homo sapiens_hsa04330	0.75063054
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.73842148
36	Choline metabolism in cancer_Homo sapiens_hsa05231	0.72221867
37	Adherens junction_Homo sapiens_hsa04520	0.71993036
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70220571
39	Taste transduction_Homo sapiens_hsa04742	0.64191145
40	Olfactory transduction_Homo sapiens_hsa04740	0.63988651
41	Hepatitis C_Homo sapiens_hsa05160	0.63897643
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61751408
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58315707
44	Complement and coagulation cascades_Homo sapiens_hsa04610	0.57183701
45	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.56133052
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55880922
47	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.55492946
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52041148
49	Phototransduction_Homo sapiens_hsa04744	0.43093123
50	PPAR signaling pathway_Homo sapiens_hsa03320	0.41160421
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41114303
52	Serotonergic synapse_Homo sapiens_hsa04726	0.38961433
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37261637
54	Pancreatic secretion_Homo sapiens_hsa04972	0.35655600
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35334808
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.33267420
57	Amoebiasis_Homo sapiens_hsa05146	0.31884055
58	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.31807210
59	Nicotine addiction_Homo sapiens_hsa05033	0.31283978
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.30926951
61	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29896113
62	Allograft rejection_Homo sapiens_hsa05330	0.28618973
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28539719
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27714554
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27672601
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.26136712
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.26099490
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.26037309
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.25827372
70	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.24897429
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24665833
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.23679981
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.22876868
74	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.22748511
75	Asthma_Homo sapiens_hsa05310	0.22216339
76	Lysosome_Homo sapiens_hsa04142	0.21676055
77	Metabolic pathways_Homo sapiens_hsa01100	0.21336521
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.20906378
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.20557276
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.19581388
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19515126
82	Bile secretion_Homo sapiens_hsa04976	0.19401449
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18998260
84	Cocaine addiction_Homo sapiens_hsa05030	0.18756791
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.18745999
86	Phagosome_Homo sapiens_hsa04145	0.18218691
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.17911717
88	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.15880435
89	Insulin resistance_Homo sapiens_hsa04931	0.15368014
90	Endocytosis_Homo sapiens_hsa04144	0.14916579
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.12959751
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.11315744
93	Amphetamine addiction_Homo sapiens_hsa05031	0.10985617
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.10196630
95	ECM-receptor interaction_Homo sapiens_hsa04512	0.10118092
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.10116619
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.09666848
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.08979385
99	Gastric acid secretion_Homo sapiens_hsa04971	0.08413729
100	Nitrogen metabolism_Homo sapiens_hsa00910	0.07611845

C1ORF87

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »