C1QA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)6.51621361
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.21889932
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.21889932
4modulation by symbiont of host immune response (GO:0052553)6.21889932
5positive regulation by symbiont of host defense response (GO:0052509)6.21889932
6modulation by symbiont of host defense response (GO:0052031)6.21889932
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.21889932
8negative regulation of granulocyte differentiation (GO:0030853)6.00298238
9positive regulation of chemokine secretion (GO:0090197)5.94927167
10regulation of interferon-beta biosynthetic process (GO:0045357)5.83596479
11macrophage activation involved in immune response (GO:0002281)5.65993267
12mannose metabolic process (GO:0006013)5.41357774
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83691504
14apoptotic cell clearance (GO:0043277)4.64002475
15complement activation, alternative pathway (GO:0006957)4.44635965
16macrophage activation (GO:0042116)4.44612298
17regulation of chemokine secretion (GO:0090196)4.36057575
18regulation of apoptotic cell clearance (GO:2000425)4.27140722
19keratan sulfate catabolic process (GO:0042340)4.25907071
20amino sugar catabolic process (GO:0046348)4.20826813
21cellular response to thyroid hormone stimulus (GO:0097067)4.20241810
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.14788777
23regulation of macrophage chemotaxis (GO:0010758)4.12513685
24positive regulation of interferon-alpha production (GO:0032727)4.11698221
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.00653994
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.98471429
27adhesion of symbiont to host cell (GO:0044650)3.94546111
28virion attachment to host cell (GO:0019062)3.94546111
29positive regulation of antigen processing and presentation (GO:0002579)3.89569940
30negative regulation of cell killing (GO:0031342)3.87004468
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87004468
32regulation of interferon-alpha production (GO:0032647)3.86402860
33regulation of B cell receptor signaling pathway (GO:0050855)3.86222848
34T-helper 1 type immune response (GO:0042088)3.84215409
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78035850
36response to host immune response (GO:0052572)3.78035850
37myeloid dendritic cell differentiation (GO:0043011)3.68773932
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68654001
39response to host (GO:0075136)3.68654001
40response to host defenses (GO:0052200)3.68654001
41cellular extravasation (GO:0045123)3.61165540
42N-acetylneuraminate metabolic process (GO:0006054)3.59747951
43hyaluronan catabolic process (GO:0030214)3.56614363
44NIK/NF-kappaB signaling (GO:0038061)3.53583685
45negative regulation of nitric oxide biosynthetic process (GO:0045019)3.49825635
46adhesion of symbiont to host (GO:0044406)3.48467533
47germinal center formation (GO:0002467)3.45366724
48regulation of cytokine secretion involved in immune response (GO:0002739)3.44742152
49barbed-end actin filament capping (GO:0051016)3.43710559
50membrane lipid catabolic process (GO:0046466)3.43064153
51monocyte chemotaxis (GO:0002548)3.41935936
52eosinophil chemotaxis (GO:0048245)3.41569743
53negative regulation of interleukin-6 production (GO:0032715)3.41508516
54regulation of integrin activation (GO:0033623)3.39880372
55sphingolipid catabolic process (GO:0030149)3.37622502
56I-kappaB phosphorylation (GO:0007252)3.37509825
57immunoglobulin mediated immune response (GO:0016064)3.37484751
58interferon-gamma-mediated signaling pathway (GO:0060333)3.35920140
59positive regulation of chemokine biosynthetic process (GO:0045080)3.35647202
60lipoxygenase pathway (GO:0019372)3.33403097
61regulation of vitamin D biosynthetic process (GO:0060556)3.33358830
62response to thyroid hormone (GO:0097066)3.33173353
63response to peptidoglycan (GO:0032494)3.32485568
64myeloid dendritic cell activation (GO:0001773)3.28506977
65negative regulation of macrophage differentiation (GO:0045650)3.28463424
66glycosphingolipid catabolic process (GO:0046479)3.27794539
67* complement activation (GO:0006956)3.26082048
68regulation of antigen processing and presentation (GO:0002577)3.23427991
69detection of molecule of bacterial origin (GO:0032490)3.23142246
70respiratory burst (GO:0045730)3.18284666
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17225793
72regulation of podosome assembly (GO:0071801)3.16297327
73negative regulation of cytokine production involved in immune response (GO:0002719)3.15219466
74positive regulation of gamma-delta T cell activation (GO:0046645)3.14664148
75neutrophil activation involved in immune response (GO:0002283)3.12646556
76positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.12539280
77regulation of mononuclear cell migration (GO:0071675)3.10614518
78myeloid cell activation involved in immune response (GO:0002275)3.08118660
79adenosine receptor signaling pathway (GO:0001973)3.07857311
80eosinophil migration (GO:0072677)3.07686975
81negative regulation of interleukin-12 production (GO:0032695)3.07460471
82positive regulation of mast cell activation involved in immune response (GO:0033008)3.06895507
83positive regulation of mast cell degranulation (GO:0043306)3.06895507
84positive regulation of heat generation (GO:0031652)3.04231927
85B cell mediated immunity (GO:0019724)3.03533775
86dendritic cell differentiation (GO:0097028)3.02213191
87positive regulation of leukocyte degranulation (GO:0043302)3.01990937
88G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.01593326
89positive regulation of cellular amide metabolic process (GO:0034250)3.00667887
90positive regulation of monocyte chemotaxis (GO:0090026)2.99639797
91positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.96258174
92positive regulation of B cell differentiation (GO:0045579)2.95895554
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.95014463
94granulocyte activation (GO:0036230)2.94579074
95regulation of complement activation (GO:0030449)2.92624247
96regulation of cholesterol storage (GO:0010885)2.92424375
97regulation of phagocytosis (GO:0050764)2.92063502
98regulation of chemokine biosynthetic process (GO:0045073)2.91870951
99angiotensin maturation (GO:0002003)2.91352843
100glycolipid catabolic process (GO:0019377)2.91343434
101oligosaccharide catabolic process (GO:0009313)2.90619504
102regulation of membrane protein ectodomain proteolysis (GO:0051043)2.89270025
103hydrogen peroxide biosynthetic process (GO:0050665)2.87433273
104regulation of vitamin metabolic process (GO:0030656)2.87241900
105endothelial cell chemotaxis (GO:0035767)2.85245990
106pinocytosis (GO:0006907)2.85051420
107response to muramyl dipeptide (GO:0032495)2.83939035
108regulation of T-helper 1 cell differentiation (GO:0045625)2.82457785
109adaptation of signaling pathway (GO:0023058)2.82450734
110regulation of fever generation (GO:0031620)2.82114061
111cellular response to interferon-gamma (GO:0071346)2.82021230
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81042556
113production of molecular mediator involved in inflammatory response (GO:0002532)2.80903273
114regulation of mast cell activation involved in immune response (GO:0033006)2.80852674
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.80842512
116regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79185344
117* complement activation, classical pathway (GO:0006958)2.79130143
118positive regulation of phagocytosis (GO:0050766)2.78555190
119macrophage differentiation (GO:0030225)2.77842640
120response to protozoan (GO:0001562)2.77696841
121regulation of protein activation cascade (GO:2000257)2.77664790
122chondroitin sulfate catabolic process (GO:0030207)2.76557846
123positive regulation of mast cell activation (GO:0033005)2.76385193
124negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76103286
125regulation of inflammatory response to antigenic stimulus (GO:0002861)2.75667314
126detection of external biotic stimulus (GO:0098581)2.75381092
127positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.75187745
128defense response to protozoan (GO:0042832)2.74744046
129low-density lipoprotein particle clearance (GO:0034383)2.74469507
130negative regulation of bone resorption (GO:0045779)2.74188818
131regulation of leukocyte degranulation (GO:0043300)2.74122139
132fat-soluble vitamin biosynthetic process (GO:0042362)2.73857146
133pathway-restricted SMAD protein phosphorylation (GO:0060389)2.72198248
134positive regulation of cholesterol efflux (GO:0010875)2.70458719
135response to cholesterol (GO:0070723)2.68873582
136regulation of granulocyte differentiation (GO:0030852)2.68683094
137cellular response to lipopolysaccharide (GO:0071222)2.68424671
138detection of other organism (GO:0098543)2.68372594
139regulation of monocyte chemotaxis (GO:0090025)2.68199881
140response to interferon-gamma (GO:0034341)2.68031385
141type I interferon signaling pathway (GO:0060337)2.67530896
142cellular response to type I interferon (GO:0071357)2.67530896
143response to laminar fluid shear stress (GO:0034616)2.66320098
144protein carboxylation (GO:0018214)2.64407858
145peptidyl-glutamic acid carboxylation (GO:0017187)2.64407858
146positive regulation of Rap GTPase activity (GO:0032854)2.63482394
147negative regulation of erythrocyte differentiation (GO:0045647)2.62395476
148negative regulation of tissue remodeling (GO:0034104)2.62151380
149phagocytosis, engulfment (GO:0006911)2.61326004
150regulation of interleukin-8 biosynthetic process (GO:0045414)2.59910641
151positive regulation of interferon-beta production (GO:0032728)2.59640282
152ruffle organization (GO:0031529)2.59524821
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58170287
154lymphocyte chemotaxis (GO:0048247)2.57359459
155purinergic receptor signaling pathway (GO:0035587)2.57176747
156antigen processing and presentation of endogenous antigen (GO:0019883)2.55749714
157ceramide catabolic process (GO:0046514)2.55659962
158regulation of mast cell degranulation (GO:0043304)2.50713905
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50221165
160lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49499096
161cyclooxygenase pathway (GO:0019371)2.47785852
162leukotriene metabolic process (GO:0006691)2.47479336
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45659408
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45659408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.17385693
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.94094766
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.20435277
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90144746
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.60724780
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.36040667
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13085199
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.86897226
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76893670
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74828558
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67433523
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46766540
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36746698
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32686425
15SCL_19346495_ChIP-Seq_HPC-7_Human2.28642029
16SPI1_23127762_ChIP-Seq_K562_Human2.26414253
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.15931568
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10348800
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.05697919
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03220469
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01856518
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01010530
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89976195
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84431526
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83783435
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77307119
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76740713
28VDR_24763502_ChIP-Seq_THP-1_Human1.73498538
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70812897
30VDR_24787735_ChIP-Seq_THP-1_Human1.69428821
31VDR_21846776_ChIP-Seq_THP-1_Human1.66675297
32RUNX_20019798_ChIP-Seq_JUKART_Human1.65789627
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63105222
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61589809
35TCF7_22412390_ChIP-Seq_EML_Mouse1.61430462
36* LXR_22292898_ChIP-Seq_THP-1_Human1.55912732
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54368855
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53208099
39* SPI1_23547873_ChIP-Seq_NB4_Human1.51296326
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50894416
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.48260537
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48192442
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47665809
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47537629
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47111093
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46380778
47CLOCK_20551151_ChIP-Seq_293T_Human1.44356581
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.43368504
49PU_27001747_Chip-Seq_BMDM_Mouse1.37663073
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.37565659
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36280419
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35590885
53GATA1_19941826_ChIP-Seq_K562_Human1.35256384
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34648244
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34340583
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31327929
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29242616
58MAF_26560356_Chip-Seq_TH1_Human1.29207007
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28766201
60* KDM2B_26808549_Chip-Seq_DND41_Human1.25870132
61STAT1_20625510_ChIP-Seq_HELA_Human1.25043005
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24819230
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.23417324
64GATA2_19941826_ChIP-Seq_K562_Human1.21471770
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21023362
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.21022355
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.18622558
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18435086
69BCL6_27268052_Chip-Seq_Bcells_Human1.17278833
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17276881
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17232359
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16075290
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15038189
74BCOR_27268052_Chip-Seq_Bcells_Human1.14552524
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12623983
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11175951
77GATA1_22025678_ChIP-Seq_K562_Human1.11142875
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09109235
79* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09060229
80TFEB_21752829_ChIP-Seq_HELA_Human1.08356027
81SPI1_20517297_ChIP-Seq_HL60_Human1.08230892
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07563677
83MYC_22102868_ChIP-Seq_BL_Human1.07207210
84* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05684371
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.05667717
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05639297
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04127385
88* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03771556
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02743401
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01148539
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.00705200
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00704857
93EGR1_19032775_ChIP-ChIP_M12_Human1.00677819
94MYB_26560356_Chip-Seq_TH2_Human1.00321027
95RACK7_27058665_Chip-Seq_MCF-7_Human1.00276834
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97909236
97* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97859394
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96468633
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96446713
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95720423
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95445279
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95397499
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95150555
104UTX_26944678_Chip-Seq_JUKART_Human0.94429100
105MAF_26560356_Chip-Seq_TH2_Human0.92798234
106* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92386139
107STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91267989
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90871060
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88999032
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87959735
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87016410
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86545608
113GATA3_27048872_Chip-Seq_THYMUS_Human0.85005036
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84772492
115MYB_26560356_Chip-Seq_TH1_Human0.84319250
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84279096
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84267680
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82829202
119KDM2B_26808549_Chip-Seq_K562_Human0.82199073
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80785103
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.80568023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.17494749
2MP0003191_abnormal_cellular_cholesterol4.53554998
3MP0009840_abnormal_foam_cell3.95281529
4MP0006082_CNS_inflammation3.59004998
5MP0003172_abnormal_lysosome_physiology3.22647828
6MP0003303_peritoneal_inflammation3.11774849
7MP0001835_abnormal_antigen_presentation2.96968490
8MP0003436_decreased_susceptibility_to2.89300305
9MP0002419_abnormal_innate_immunity2.63785984
10MP0003690_abnormal_glial_cell2.59616305
11MP0003075_altered_response_to2.59141672
12MP0005464_abnormal_platelet_physiology2.33073618
13MP0008438_abnormal_cutaneous_collagen2.31602051
14MP0001533_abnormal_skeleton_physiology2.20008255
15MP0003724_increased_susceptibility_to2.19598832
16MP0002148_abnormal_hypersensitivity_rea2.17183238
17MP0003300_gastrointestinal_ulcer2.12855667
18MP0003806_abnormal_nucleotide_metabolis2.03079316
19MP0001790_abnormal_immune_system1.98666980
20MP0005387_immune_system_phenotype1.98666980
21* MP0005000_abnormal_immune_tolerance1.96906940
22MP0000343_altered_response_to1.94787799
23* MP0005025_abnormal_response_to1.90044167
24MP0002452_abnormal_antigen_presenting1.89563854
25MP0005671_abnormal_response_to1.82809711
26MP0000604_amyloidosis1.82042114
27MP0004510_myositis1.76968931
28MP0000685_abnormal_immune_system1.75757115
29MP0001800_abnormal_humoral_immune1.75014452
30MP0003705_abnormal_hypodermis_morpholog1.70819793
31MP0002723_abnormal_immune_serum1.64715868
32MP0005670_abnormal_white_adipose1.56710480
33MP0008469_abnormal_protein_level1.56348002
34MP0003183_abnormal_peptide_metabolism1.55138834
35MP0005166_decreased_susceptibility_to1.54547080
36MP0006054_spinal_hemorrhage1.50714189
37MP0003566_abnormal_cell_adhesion1.47980199
38MP0001819_abnormal_immune_cell1.47840341
39MP0003453_abnormal_keratinocyte_physiol1.47633325
40MP0008004_abnormal_stomach_pH1.46577292
41MP0003329_amyloid_beta_deposits1.46389307
42MP0002420_abnormal_adaptive_immunity1.45754583
43MP0005167_abnormal_blood-brain_barrier1.45168086
44MP0009785_altered_susceptibility_to1.45070903
45MP0001851_eye_inflammation1.44416658
46MP0005451_abnormal_body_composition1.43767361
47MP0004947_skin_inflammation1.37459971
48* MP0001845_abnormal_inflammatory_respons1.36949492
49MP0000858_altered_metastatic_potential1.35822465
50MP0009333_abnormal_splenocyte_physiolog1.34451467
51MP0002998_abnormal_bone_remodeling1.34075430
52MP0004185_abnormal_adipocyte_glucose1.33947355
53MP0003252_abnormal_bile_duct1.31826598
54MP0002405_respiratory_system_inflammati1.28484909
55MP0009278_abnormal_bone_marrow1.26344931
56MP0000465_gastrointestinal_hemorrhage1.23695652
57MP0000249_abnormal_blood_vessel1.23239552
58MP0002138_abnormal_hepatobiliary_system1.19261080
59MP0002166_altered_tumor_susceptibility1.17275220
60MP0010329_abnormal_lipoprotein_level1.16626434
61MP0004130_abnormal_muscle_cell1.16485781
62MP0000767_abnormal_smooth_muscle1.13044197
63MP0001915_intracranial_hemorrhage1.11621794
64MP0002254_reproductive_system_inflammat1.11236481
65MP0000609_abnormal_liver_physiology1.10762757
66MP0003045_fibrosis1.10101739
67MP0002090_abnormal_vision1.09092067
68MP0003279_aneurysm1.09072427
69MP0005085_abnormal_gallbladder_physiolo1.08317451
70MP0001853_heart_inflammation1.07466877
71MP0000689_abnormal_spleen_morphology1.07284081
72MP0005023_abnormal_wound_healing1.05151767
73MP0005310_abnormal_salivary_gland1.03329638
74MP0000716_abnormal_immune_system1.02842266
75MP0001542_abnormal_bone_strength1.01964625
76MP0005390_skeleton_phenotype1.01692134
77MP0004883_abnormal_blood_vessel1.01392747
78MP0009763_increased_sensitivity_to1.00896171
79MP0003195_calcinosis0.97002806
80MP0008260_abnormal_autophagy0.96791330
81MP0005666_abnormal_adipose_tissue0.96663492
82MP0003448_altered_tumor_morphology0.95525389
83MP0005165_increased_susceptibility_to0.95262672
84MP0001663_abnormal_digestive_system0.94185766
85MP0002139_abnormal_hepatobiliary_system0.92490075
86MP0005360_urolithiasis0.89859326
87MP0005365_abnormal_bile_salt0.87964437
88MP0002928_abnormal_bile_duct0.87955832
89MP0003634_abnormal_glial_cell0.85901202
90MP0002933_joint_inflammation0.84605233
91MP0008873_increased_physiological_sensi0.83897984
92MP0002118_abnormal_lipid_homeostasis0.83708589
93MP0010155_abnormal_intestine_physiology0.82198566
94MP0009764_decreased_sensitivity_to0.80917905
95MP0005595_abnormal_vascular_smooth0.80170131
96MP0005584_abnormal_enzyme/coenzyme_acti0.79931779
97MP0002429_abnormal_blood_cell0.79713664
98MP0002837_dystrophic_cardiac_calcinosis0.79640809
99MP0003795_abnormal_bone_structure0.78690238
100MP0002722_abnormal_immune_system0.78631339
101MP0010368_abnormal_lymphatic_system0.77814626
102MP0002398_abnormal_bone_marrow0.77740534
103MP0003828_pulmonary_edema0.76565431
104MP0000920_abnormal_myelination0.76329050
105MP0005397_hematopoietic_system_phenotyp0.76036223
106MP0001545_abnormal_hematopoietic_system0.76036223
107MP0010307_abnormal_tumor_latency0.75167580
108MP0005164_abnormal_response_to0.74982598
109MP0003638_abnormal_response/metabolism_0.72982460
110MP0002277_abnormal_respiratory_mucosa0.72723988
111MP0009643_abnormal_urine_homeostasis0.72549825
112MP0002909_abnormal_adrenal_gland0.72521117
113MP0003633_abnormal_nervous_system0.72060524
114MP0002332_abnormal_exercise_endurance0.71400386
115MP0000598_abnormal_liver_morphology0.70717253
116MP0003656_abnormal_erythrocyte_physiolo0.70677122
117MP0004019_abnormal_vitamin_homeostasis0.70431393
118MP0005647_abnormal_sex_gland0.70384377
119MP0001873_stomach_inflammation0.68797789
120MP0003091_abnormal_cell_migration0.68021438
121MP0003879_abnormal_hair_cell0.67325814
122MP0002006_tumorigenesis0.66405861
123MP0008874_decreased_physiological_sensi0.65213183
124MP0003186_abnormal_redox_activity0.64651289
125MP0004858_abnormal_nervous_system0.63904169
126MP0005319_abnormal_enzyme/_coenzyme0.63573023
127MP0005381_digestive/alimentary_phenotyp0.61595040

Predicted human phenotypes

RankGene SetZ-score
1* Glomerulonephritis (HP:0000099)7.39574483
2* Complement deficiency (HP:0004431)6.52243676
3* Abnormality of complement system (HP:0005339)5.73827583
4Abnormality of glycolipid metabolism (HP:0010969)5.69101975
5Abnormality of liposaccharide metabolism (HP:0010968)5.69101975
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.69101975
7Dysostosis multiplex (HP:0000943)5.66278269
8Increased cerebral lipofuscin (HP:0011813)5.22739156
9Vacuolated lymphocytes (HP:0001922)4.72371691
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.72265773
11Recurrent abscess formation (HP:0002722)4.56159340
12Mucopolysacchariduria (HP:0008155)4.43289883
13Urinary glycosaminoglycan excretion (HP:0003541)4.43289883
14Cerebral aneurysm (HP:0004944)4.31343778
15Abnormality of mucopolysaccharide metabolism (HP:0011020)4.15769012
16Abnormality of polysaccharide metabolism (HP:0011012)4.15769012
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.15769012
18Recurrent bacterial skin infections (HP:0005406)4.15277777
19* Nephritis (HP:0000123)4.01355755
20Recurrent gram-negative bacterial infections (HP:0005420)3.96736823
21Eczematoid dermatitis (HP:0000976)3.89976275
22Arterial tortuosity (HP:0005116)3.89930452
23Nuclear cataract (HP:0100018)3.77011286
24Mutism (HP:0002300)3.72266737
25Axonal loss (HP:0003447)3.60724439
26Retinal atrophy (HP:0001105)3.49544351
27Asymmetric septal hypertrophy (HP:0001670)3.48072219
28Vascular tortuosity (HP:0004948)3.40830745
29Disinhibition (HP:0000734)3.37665896
30Hematochezia (HP:0002573)3.17130856
31Loss of speech (HP:0002371)3.07778968
32Purpura (HP:0000979)3.05324641
33Spondylolisthesis (HP:0003302)2.83380866
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81340109
35Orchitis (HP:0100796)2.77298816
36Cerebral inclusion bodies (HP:0100314)2.77022752
37Abnormality of macrophages (HP:0004311)2.75954534
38Increased serum ferritin (HP:0003281)2.65924976
39Personality changes (HP:0000751)2.65924912
40Aortic aneurysm (HP:0004942)2.64840838
41Upper motor neuron abnormality (HP:0002127)2.62796447
42Neuronal loss in central nervous system (HP:0002529)2.61007106
43Progressive neurologic deterioration (HP:0002344)2.60284091
44Malnutrition (HP:0004395)2.56626729
45Myocardial infarction (HP:0001658)2.54579452
46Striae distensae (HP:0001065)2.53946098
47J-shaped sella turcica (HP:0002680)2.53258285
48Thoracic kyphosis (HP:0002942)2.51365031
49Stomatitis (HP:0010280)2.50434053
50Pathologic fracture (HP:0002756)2.50404409
51Joint stiffness (HP:0001387)2.49230311
52Colitis (HP:0002583)2.47965867
53Amyloidosis (HP:0011034)2.47567553
54Retrobulbar optic neuritis (HP:0100654)2.46569926
55Optic neuritis (HP:0100653)2.46569926
56Disproportionate tall stature (HP:0001519)2.45809224
57Agnosia (HP:0010524)2.38643516
58Aortic dissection (HP:0002647)2.38546913
59Spontaneous hematomas (HP:0007420)2.35055709
60Metaphyseal irregularity (HP:0003025)2.34746959
61Recurrent skin infections (HP:0001581)2.32513077
62Abnormality of the lumbar spine (HP:0100712)2.31741081
63Pustule (HP:0200039)2.28726505
64Prolonged neonatal jaundice (HP:0006579)2.27596244
65Hepatosplenomegaly (HP:0001433)2.27317403
66Conjunctival telangiectasia (HP:0000524)2.23174729
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22786004
68Petechiae (HP:0000967)2.22505866
69Polygenic inheritance (HP:0010982)2.21362196
70Abnormality of iron homeostasis (HP:0011031)2.19194205
71Cardiomegaly (HP:0001640)2.17843649
72Gingivitis (HP:0000230)2.17550037
73Pulmonary infiltrates (HP:0002113)2.15957374
74Deep venous thrombosis (HP:0002625)2.15390775
75Ovoid vertebral bodies (HP:0003300)2.13298054
76Apathy (HP:0000741)2.07498698
77Joint hemorrhage (HP:0005261)2.03981663
78Bone pain (HP:0002653)2.03567256
79Supranuclear gaze palsy (HP:0000605)2.01861728
80Neurofibrillary tangles (HP:0002185)2.01615213
81Hemoptysis (HP:0002105)2.00294261
82* Systemic lupus erythematosus (HP:0002725)10.0015186
83Urethral obstruction (HP:0000796)1.99825061
84Diminished motivation (HP:0000745)1.99211759
85Vertebral compression fractures (HP:0002953)1.98147935
86Elevated erythrocyte sedimentation rate (HP:0003565)1.95173428
87Memory impairment (HP:0002354)1.95138497
88Inflammation of the large intestine (HP:0002037)1.92414871
89Shallow orbits (HP:0000586)1.91637980
90Peripheral demyelination (HP:0011096)1.91042044
91Mitral valve prolapse (HP:0001634)1.90333018
92Increased CSF protein (HP:0002922)1.89464814
93Polyneuropathy (HP:0001271)1.89444445
94Nausea (HP:0002018)1.87515068
95Osteolytic defects of the hand bones (HP:0009699)1.86270215
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.86270215
97Interstitial pulmonary disease (HP:0006530)1.86090114
98Progressive visual loss (HP:0000529)1.85730630
99Thick nail (HP:0001805)1.84773410
100Dementia (HP:0000726)1.83657984
101Deformed sella turcica (HP:0002681)1.83601893
102Xanthomatosis (HP:0000991)1.81888761
103Periodontitis (HP:0000704)1.81880953
104Myositis (HP:0100614)1.81564320
105Bone cyst (HP:0012062)1.81505097
106Vasculitis (HP:0002633)1.80498322
107Abnormality of the thoracic spine (HP:0100711)1.79357537
108Restrictive lung disease (HP:0002091)1.78874799
109Mediastinal lymphadenopathy (HP:0100721)1.78825229
110Gastrointestinal inflammation (HP:0004386)1.78063625
111Basal ganglia calcification (HP:0002135)1.76250503
112Peritonitis (HP:0002586)1.75977511
113Meningitis (HP:0001287)1.73895814
114Abnormality of transition element cation homeostasis (HP:0011030)1.73869823
115Abnormality of the nasal mucosa (HP:0000433)1.73236163
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73094383
117Abnormality of the periventricular white matter (HP:0002518)1.73091023
118Autoimmune thrombocytopenia (HP:0001973)1.73077694
119Recurrent fungal infections (HP:0002841)1.72251508
120Cellulitis (HP:0100658)1.72193510
121Coarse hair (HP:0002208)1.71356442
122Obstructive lung disease (HP:0006536)1.71185556
123Chronic obstructive pulmonary disease (HP:0006510)1.71185556
124Abnormality of the basal ganglia (HP:0002134)1.70764138
125Orthostatic hypotension (HP:0001278)1.70665782
126Cervical subluxation (HP:0003308)1.69792860
127Global brain atrophy (HP:0002283)1.69729299
128Mitral stenosis (HP:0001718)1.69550633
129Mucosal telangiectasiae (HP:0100579)1.68206399
130Keratoconjunctivitis sicca (HP:0001097)1.67825953
131Inappropriate behavior (HP:0000719)1.67428434
132Gastrointestinal stroma tumor (HP:0100723)1.67363246
133Hand muscle atrophy (HP:0009130)1.67001485
134Impaired platelet aggregation (HP:0003540)1.66482236
135Abnormal platelet function (HP:0011869)1.66482236
136Acrocyanosis (HP:0001063)1.66235135
137Urticaria (HP:0001025)1.62797614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.51233023
2NME24.51156745
3BLK3.71068035
4MAPK153.30556017
5ERN13.25071407
6CAMK1D3.08881199
7TYK23.08814595
8CSF1R2.99817362
9DDR22.69923714
10GRK72.61478722
11TAOK22.36957150
12CAMK1G2.31456980
13TRIB32.29787237
14MST1R2.25514195
15TBK12.15830504
16ACVR1B2.08365000
17RIPK42.05314344
18TAOK12.01883243
19PAK41.90235324
20PKN21.86721053
21EPHB11.83690574
22IRAK41.81211673
23PIM21.80419728
24MAP4K11.75650859
25JAK11.68796556
26ABL21.67805296
27RIPK11.58984074
28CAMKK21.56458425
29CDC42BPA1.50943291
30IRAK31.47929461
31PRPF4B1.45954663
32CSK1.41426776
33ZAP701.40228880
34MAP2K31.35794892
35FES1.34821794
36KIT1.34102480
37TESK11.33669405
38PTK61.32657930
39HCK1.31802234
40CAMKK11.30149242
41TSSK61.30025521
42MATK1.19440389
43STK101.16868681
44MAP3K141.15998774
45JAK21.14669888
46TESK21.07027719
47EPHB21.05718355
48SCYL21.01006300
49NEK90.96556640
50CLK10.93072682
51MAPK120.92091325
52FGR0.91525759
53CHUK0.90884577
54TGFBR10.90444069
55TTN0.89657645
56TAOK30.86174198
57IKBKB0.85795064
58IKBKE0.81554595
59LCK0.81222919
60MOS0.80986346
61MAP3K130.80383394
62DAPK20.77646775
63LYN0.76945229
64MAP2K60.75183645
65SYK0.72968392
66MAP3K50.72642325
67BMX0.71629259
68MAP3K30.69934840
69IGF1R0.67998449
70BMPR20.67165708
71FGFR40.66143019
72PIK3CG0.65629602
73MET0.65245599
74BTK0.63858601
75PDPK10.62520053
76PAK20.62254776
77SIK30.61035037
78PDK10.60501502
79PDGFRA0.59749964
80CDK60.59379243
81PRKG20.57760078
82TYRO30.57391628
83IRAK20.56775575
84ITK0.56669090
85TNK20.56462797
86ARAF0.55868127
87EEF2K0.55863377
88CAMK40.55672333
89EGFR0.54726620
90MAPKAPK30.52406056
91SIK20.51728764
92GSK3A0.49109708
93IRAK10.48685483
94MAPKAPK20.48440999
95MAP3K90.48096350
96GRK50.47695436
97PRKCH0.47051190
98ICK0.46424318
99MAP3K110.46286183
100JAK30.45338887
101MAP3K100.44381023
102LRRK20.43403673
103RPS6KA20.43271377
104LIMK10.42687744
105RET0.42658489
106TXK0.42329769
107MARK30.42325984
108EPHA30.41465745
109DAPK30.40687105
110RPS6KA40.40366244
111SIK10.38905733
112ABL10.38283973
113ADRBK20.38117495
114PIM10.38049216
115FGFR30.37698815
116MAPK70.37335342
117MAP3K10.36467184
118KSR20.35888118
119FYN0.35360704
120PTK2B0.34987236
121PRKD10.34666858
122PRKCD0.34112612
123PRKAA20.33710304
124GRK60.32372786
125PDK20.31583734
126INSR0.31501368
127RPS6KA60.31104164
128MARK20.30611732
129MAP3K60.28584099
130RPS6KL10.28395340
131RPS6KC10.28395340
132MAPK40.28250760

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051506.03110296
2Other glycan degradation_Homo sapiens_hsa005114.89909814
3Glycosaminoglycan degradation_Homo sapiens_hsa005314.79445224
4Lysosome_Homo sapiens_hsa041423.27318968
5Asthma_Homo sapiens_hsa053103.02727533
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.80673321
7* Complement and coagulation cascades_Homo sapiens_hsa046102.80574736
8Allograft rejection_Homo sapiens_hsa053302.70270826
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47022733
10* Pertussis_Homo sapiens_hsa051332.32537636
11Graft-versus-host disease_Homo sapiens_hsa053322.30494829
12Autoimmune thyroid disease_Homo sapiens_hsa053202.29204787
13Osteoclast differentiation_Homo sapiens_hsa043802.26766107
14Leishmaniasis_Homo sapiens_hsa051402.18374426
15Nitrogen metabolism_Homo sapiens_hsa009102.09692123
16* Prion diseases_Homo sapiens_hsa050201.91202010
17Type I diabetes mellitus_Homo sapiens_hsa049401.81123983
18* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64244837
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56950125
20Tuberculosis_Homo sapiens_hsa051521.52638029
21Antigen processing and presentation_Homo sapiens_hsa046121.51993817
22B cell receptor signaling pathway_Homo sapiens_hsa046621.49374365
23Legionellosis_Homo sapiens_hsa051341.41762606
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35843141
25Malaria_Homo sapiens_hsa051441.28957454
26Phagosome_Homo sapiens_hsa041451.26735450
27Collecting duct acid secretion_Homo sapiens_hsa049661.24367611
28Toxoplasmosis_Homo sapiens_hsa051451.23300499
29Caffeine metabolism_Homo sapiens_hsa002321.22414895
30Chemokine signaling pathway_Homo sapiens_hsa040621.07455835
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04241729
32ABC transporters_Homo sapiens_hsa020100.94810051
33Salmonella infection_Homo sapiens_hsa051320.93115069
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92605431
35Primary bile acid biosynthesis_Homo sapiens_hsa001200.87040249
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83600050
37Endocytosis_Homo sapiens_hsa041440.82645509
38Amoebiasis_Homo sapiens_hsa051460.81039081
39Measles_Homo sapiens_hsa051620.80904161
40Hematopoietic cell lineage_Homo sapiens_hsa046400.80638327
41Influenza A_Homo sapiens_hsa051640.80095624
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.79916362
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79507290
44Platelet activation_Homo sapiens_hsa046110.78820334
45Vibrio cholerae infection_Homo sapiens_hsa051100.78801182
46Sulfur metabolism_Homo sapiens_hsa009200.78422576
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78100007
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75973026
49Bladder cancer_Homo sapiens_hsa052190.75756939
50Rheumatoid arthritis_Homo sapiens_hsa053230.75501912
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75195933
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73899814
53Galactose metabolism_Homo sapiens_hsa000520.72723831
54Pancreatic cancer_Homo sapiens_hsa052120.71873321
55PPAR signaling pathway_Homo sapiens_hsa033200.70976219
56Chronic myeloid leukemia_Homo sapiens_hsa052200.69702759
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68142074
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67930330
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65395098
60Arginine biosynthesis_Homo sapiens_hsa002200.64742241
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64486565
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64279125
63Arachidonic acid metabolism_Homo sapiens_hsa005900.62973846
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.60605232
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57430654
66Apoptosis_Homo sapiens_hsa042100.57199040
67Shigellosis_Homo sapiens_hsa051310.55978075
68Fructose and mannose metabolism_Homo sapiens_hsa000510.51578358
69Renal cell carcinoma_Homo sapiens_hsa052110.51204582
70Primary immunodeficiency_Homo sapiens_hsa053400.51176433
71TNF signaling pathway_Homo sapiens_hsa046680.50248081
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.49951935
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49268216
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49025199
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.46403913
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.46239751
77Insulin resistance_Homo sapiens_hsa049310.44402044
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44249976
79Epstein-Barr virus infection_Homo sapiens_hsa051690.44197565
80Acute myeloid leukemia_Homo sapiens_hsa052210.43111446
81Hepatitis B_Homo sapiens_hsa051610.42677327
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42600281
83* Systemic lupus erythematosus_Homo sapiens_hsa053220.41694792
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41660311
85Fatty acid degradation_Homo sapiens_hsa000710.40218948
86Notch signaling pathway_Homo sapiens_hsa043300.40174139
87Glutathione metabolism_Homo sapiens_hsa004800.38824722
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.38817545
89Tryptophan metabolism_Homo sapiens_hsa003800.37073636
90Synaptic vesicle cycle_Homo sapiens_hsa047210.36965142
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36844196
92Adherens junction_Homo sapiens_hsa045200.35242790
93Hepatitis C_Homo sapiens_hsa051600.33922539
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33368099
95Type II diabetes mellitus_Homo sapiens_hsa049300.33279550
96Focal adhesion_Homo sapiens_hsa045100.33064401
97Proteoglycans in cancer_Homo sapiens_hsa052050.32819057
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.32501649
99Rap1 signaling pathway_Homo sapiens_hsa040150.31423587
100Colorectal cancer_Homo sapiens_hsa052100.31039808
101Starch and sucrose metabolism_Homo sapiens_hsa005000.30954822
102Bile secretion_Homo sapiens_hsa049760.30323111
103Histidine metabolism_Homo sapiens_hsa003400.30063184
104Estrogen signaling pathway_Homo sapiens_hsa049150.29543060
105VEGF signaling pathway_Homo sapiens_hsa043700.29440666
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26984386
107Viral myocarditis_Homo sapiens_hsa054160.26487990
108African trypanosomiasis_Homo sapiens_hsa051430.25212960
109HTLV-I infection_Homo sapiens_hsa051660.24110638
110Fatty acid metabolism_Homo sapiens_hsa012120.24068806
111N-Glycan biosynthesis_Homo sapiens_hsa005100.22645858
112Sphingolipid metabolism_Homo sapiens_hsa006000.22411609
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.22181387
114MAPK signaling pathway_Homo sapiens_hsa040100.21783014
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21121908
116Herpes simplex infection_Homo sapiens_hsa051680.20313909
117Prolactin signaling pathway_Homo sapiens_hsa049170.19701313
118T cell receptor signaling pathway_Homo sapiens_hsa046600.19196709
119Renin-angiotensin system_Homo sapiens_hsa046140.18491213
120HIF-1 signaling pathway_Homo sapiens_hsa040660.18043626
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17640535
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17562655
123Mineral absorption_Homo sapiens_hsa049780.17505533
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17471521
125Vitamin digestion and absorption_Homo sapiens_hsa049770.14589747
126Ether lipid metabolism_Homo sapiens_hsa005650.14342667
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13112159
128GnRH signaling pathway_Homo sapiens_hsa049120.10580110

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »