ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine ribonucleoside catabolic process (GO:0046133)	9.26049947
2	DNA deamination (GO:0045006)	7.44740281
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.85859822
4	negative regulation by host of viral transcription (GO:0043922)	5.22675515
5	pyrimidine nucleoside catabolic process (GO:0046135)	4.99066382
6	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	4.87749145
7	regulation of activation of Janus kinase activity (GO:0010533)	4.64748249
8	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.49127718
9	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.33125393
10	UMP biosynthetic process (GO:0006222)	4.33125393
11	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.33125393
12	UMP metabolic process (GO:0046049)	4.33125393
13	modulation by host of symbiont transcription (GO:0052472)	4.29887736
14	modulation by host of viral transcription (GO:0043921)	4.29887736
15	negative regulation of T cell apoptotic process (GO:0070233)	4.26860510
16	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	4.17985820
17	pyrimidine ribonucleoside metabolic process (GO:0046131)	4.13229033
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.99855044
19	opioid receptor signaling pathway (GO:0038003)	3.95947751
20	positive regulation of T cell apoptotic process (GO:0070234)	3.93357311
21	eosinophil chemotaxis (GO:0048245)	3.87582068
22	purine deoxyribonucleotide catabolic process (GO:0009155)	3.74289334
23	positive regulation of gamma-delta T cell activation (GO:0046645)	3.65125447
24	nucleotide salvage (GO:0043173)	3.63520991
25	negative regulation of viral genome replication (GO:0045071)	3.62718571
26	pyrimidine nucleotide catabolic process (GO:0006244)	3.56973536
27	pyrimidine-containing compound salvage (GO:0008655)	3.56584956
28	pyrimidine nucleoside salvage (GO:0043097)	3.56584956
29	mitochondrion transport along microtubule (GO:0047497)	3.55878239
30	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.55878239
31	response to gravity (GO:0009629)	3.54807487
32	positive regulation of granulocyte differentiation (GO:0030854)	3.53395459
33	negative regulation of telomere maintenance (GO:0032205)	3.50591441
34	deoxyribonucleotide catabolic process (GO:0009264)	3.48143048
35	eosinophil migration (GO:0072677)	3.45938060
36	pyrimidine-containing compound catabolic process (GO:0072529)	3.45347727
37	pyrimidine nucleoside metabolic process (GO:0006213)	3.35293899
38	negative regulation of organelle assembly (GO:1902116)	3.32735483
39	regulation of T cell apoptotic process (GO:0070232)	3.32487056
40	activation of MAPKKK activity (GO:0000185)	3.31629251
41	regulation of macrophage chemotaxis (GO:0010758)	3.26864154
42	DNA double-strand break processing (GO:0000729)	3.24659055
43	cell migration involved in gastrulation (GO:0042074)	3.21865056
44	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.20771271
45	deoxyribose phosphate catabolic process (GO:0046386)	3.19834484
46	arginine metabolic process (GO:0006525)	3.19488166
47	positive regulation of translational initiation (GO:0045948)	3.17223815
48	ribosomal small subunit assembly (GO:0000028)	3.16147513
49	exocrine pancreas development (GO:0031017)	3.15715334
50	macrophage chemotaxis (GO:0048246)	3.11535712
51	chaperone-mediated protein transport (GO:0072321)	3.11331803
52	NIK/NF-kappaB signaling (GO:0038061)	3.10822906
53	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.09884927
54	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.09884927
55	negative regulation of muscle hypertrophy (GO:0014741)	3.03900243
56	rRNA catabolic process (GO:0016075)	2.97584672
57	regulation of chronic inflammatory response (GO:0002676)	2.96685255
58	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.95400025
59	piRNA metabolic process (GO:0034587)	2.95306330
60	mast cell activation involved in immune response (GO:0002279)	2.90378856
61	mast cell degranulation (GO:0043303)	2.90378856
62	nitrogen cycle metabolic process (GO:0071941)	2.90365271
63	establishment of mitochondrion localization (GO:0051654)	2.90185404
64	negative regulation of viral transcription (GO:0032897)	2.89456122
65	negative regulation of DNA biosynthetic process (GO:2000279)	2.89315808
66	striated muscle atrophy (GO:0014891)	2.86444936
67	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.86200421
68	positive regulation of B cell differentiation (GO:0045579)	2.79372165
69	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.79191782
70	cytolysis (GO:0019835)	2.78719822
71	regulation of gamma-delta T cell activation (GO:0046643)	2.78280249
72	cellular zinc ion homeostasis (GO:0006882)	2.76016517
73	ncRNA 3-end processing (GO:0043628)	2.74762056
74	nucleoside salvage (GO:0043174)	2.73750046
75	skeletal muscle adaptation (GO:0043501)	2.72167142
76	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.71434795
77	neutrophil activation (GO:0042119)	2.69942710
78	lymphoid progenitor cell differentiation (GO:0002320)	2.68573867
79	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.66729923
80	positive regulation of monocyte chemotaxis (GO:0090026)	2.65806374
81	myelin assembly (GO:0032288)	2.60426139
82	regulation of viral genome replication (GO:0045069)	2.60028292
83	UV protection (GO:0009650)	2.58066459
84	positive regulation of interleukin-8 secretion (GO:2000484)	2.57209682
85	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.57129652
86	positive regulation of protein homooligomerization (GO:0032464)	2.55763929
87	regulation of T cell chemotaxis (GO:0010819)	2.55086610
88	positive regulation of T cell chemotaxis (GO:0010820)	2.55086610
89	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.54108199
90	DNA demethylation (GO:0080111)	2.53834644
91	urea cycle (GO:0000050)	2.52190300
92	negative regulation of viral process (GO:0048525)	2.51017017
93	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.50132285
94	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.50132285
95	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.49169570
96	muscle atrophy (GO:0014889)	2.48500133
97	DNA dealkylation (GO:0035510)	2.48025251
98	cytidine metabolic process (GO:0046087)	10.2739755
99	cytidine catabolic process (GO:0006216)	10.2739755
100	cytidine deamination (GO:0009972)	10.2739755

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.47903050
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.45859025
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.35000799
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.98722022
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.59047466
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.38943987
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.83301485
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.72302955
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.49604550
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48996202
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16697229
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.04880082
13	CIITA_25753668_ChIP-Seq_RAJI_Human	1.99361696
14	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.94671784
15	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.94516872
16	VDR_22108803_ChIP-Seq_LS180_Human	1.88918322
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87625546
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83083064
19	BCL6_27268052_Chip-Seq_Bcells_Human	1.78301974
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.77854840
21	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.76864486
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72677072
23	MYB_26560356_Chip-Seq_TH2_Human	1.72154841
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72092659
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.69521365
26	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.65986499
27	MAF_26560356_Chip-Seq_TH2_Human	1.63338579
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62415378
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.53937993
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53332520
31	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52729070
32	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.51621041
33	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.46992485
34	UTX_26944678_Chip-Seq_JUKART_Human	1.46944048
35	HTT_18923047_ChIP-ChIP_STHdh_Human	1.43794601
36	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.41827490
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39899568
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.37743804
39	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.35270087
40	BCOR_27268052_Chip-Seq_Bcells_Human	1.34500856
41	P300_27268052_Chip-Seq_Bcells_Human	1.33169479
42	SA1_27219007_Chip-Seq_Bcells_Human	1.32006167
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29900483
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28909849
45	PHF8_20622854_ChIP-Seq_HELA_Human	1.27694920
46	ERA_21632823_ChIP-Seq_H3396_Human	1.27460568
47	CTCF_20526341_ChIP-Seq_ESCs_Human	1.27098803
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.26301685
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.24741723
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.24303417
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23336530
52	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.22638613
53	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.20989734
54	ZNF263_19887448_ChIP-Seq_K562_Human	1.20280026
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20166421
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.17828106
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.17564545
58	RUNX_20019798_ChIP-Seq_JUKART_Human	1.16010297
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14513858
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13585492
61	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12106895
62	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.11870326
63	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10232610
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10061844
65	MYB_26560356_Chip-Seq_TH1_Human	1.09915306
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09742567
67	RAC3_21632823_ChIP-Seq_H3396_Human	1.09150882
68	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.07030631
69	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.05735939
70	GATA3_27048872_Chip-Seq_THYMUS_Human	1.05124425
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04862965
72	CTCF_21964334_Chip-Seq_Bcells_Human	1.04650717
73	P68_20966046_ChIP-Seq_HELA_Human	1.01517817
74	CBP_21632823_ChIP-Seq_H3396_Human	1.00950784
75	MAF_26560356_Chip-Seq_TH1_Human	1.00651630
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.00168979
77	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00079747
78	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.99780128
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99101083
80	TP53_22573176_ChIP-Seq_HFKS_Human	0.98683838
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97629889
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97274307
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97274307
84	PHF8_20622853_ChIP-Seq_HELA_Human	0.97088148
85	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.96790863
86	GATA3_26560356_Chip-Seq_TH2_Human	0.96279293
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.96250312
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.96189265
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95690225
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94852933
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94781249
92	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94441872
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94312440
94	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.93983595
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92740686
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90907760
97	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.90410636
98	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.90288638
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90096899
100	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89906460

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002909_abnormal_adrenal_gland	4.17870909
2	MP0003646_muscle_fatigue	3.54196809
3	MP0001873_stomach_inflammation	3.37923389
4	MP0005671_abnormal_response_to	3.29240405
5	MP0003763_abnormal_thymus_physiology	3.25518429
6	MP0000383_abnormal_hair_follicle	3.21527025
7	MP0001188_hyperpigmentation	2.97568497
8	MP0003786_premature_aging	2.66434353
9	MP0003787_abnormal_imprinting	2.62294126
10	MP0004133_heterotaxia	2.57229447
11	MP0002837_dystrophic_cardiac_calcinosis	2.47931663
12	MP0004147_increased_porphyrin_level	2.28051172
13	MP0002396_abnormal_hematopoietic_system	2.23252812
14	MP0008007_abnormal_cellular_replicative	1.97195748
15	MP0010678_abnormal_skin_adnexa	1.84670047
16	MP0004145_abnormal_muscle_electrophysio	1.76337498
17	MP0008872_abnormal_physiological_respon	1.74803910
18	MP0001919_abnormal_reproductive_system	1.73676979
19	MP0002277_abnormal_respiratory_mucosa	1.71556319
20	MP0001835_abnormal_antigen_presentation	1.70763610
21	MP0008058_abnormal_DNA_repair	1.70329159
22	MP0004043_abnormal_pH_regulation	1.67403236
23	MP0008875_abnormal_xenobiotic_pharmacok	1.66364808
24	MP0003693_abnormal_embryo_hatching	1.63866768
25	MP0002102_abnormal_ear_morphology	1.62884022
26	MP0001800_abnormal_humoral_immune	1.62127414
27	MP0002398_abnormal_bone_marrow	1.57849211
28	MP0002420_abnormal_adaptive_immunity	1.51470331
29	MP0002723_abnormal_immune_serum	1.50043283
30	MP0002405_respiratory_system_inflammati	1.46705642
31	MP0001986_abnormal_taste_sensitivity	1.44189671
32	MP0002735_abnormal_chemical_nociception	1.43622972
33	MP0005000_abnormal_immune_tolerance	1.42749343
34	MP0008057_abnormal_DNA_replication	1.42344890
35	MP0000716_abnormal_immune_system	1.40518683
36	MP0001819_abnormal_immune_cell	1.37942651
37	MP0000703_abnormal_thymus_morphology	1.35943376
38	MP0009785_altered_susceptibility_to	1.35870030
39	MP0000569_abnormal_digit_pigmentation	1.35249986
40	MP0002933_joint_inflammation	1.31563691
41	MP0001968_abnormal_touch/_nociception	1.28541429
42	MP0009333_abnormal_splenocyte_physiolog	1.27202501
43	MP0003959_abnormal_lean_body	1.26128837
44	MP0002736_abnormal_nociception_after	1.21218149
45	MP0005075_abnormal_melanosome_morpholog	1.20511259
46	MP0001501_abnormal_sleep_pattern	1.19882111
47	MP0008877_abnormal_DNA_methylation	1.18472539
48	MP0002722_abnormal_immune_system	1.17952705
49	MP0001243_abnormal_dermal_layer	1.17859109
50	MP0003806_abnormal_nucleotide_metabolis	1.17443272
51	MP0005409_darkened_coat_color	1.17030234
52	MP0002148_abnormal_hypersensitivity_rea	1.16975411
53	MP0004036_abnormal_muscle_relaxation	1.13943108
54	MP0000733_abnormal_muscle_development	1.12878399
55	MP0002095_abnormal_skin_pigmentation	1.11944708
56	MP0002429_abnormal_blood_cell	1.10928640
57	MP0002006_tumorigenesis	1.06270660
58	MP0000689_abnormal_spleen_morphology	1.02551937
59	MP0002452_abnormal_antigen_presenting	1.00432923
60	MP0005025_abnormal_response_to	0.99866056
61	MP0000230_abnormal_systemic_arterial	0.98668826
62	MP0000013_abnormal_adipose_tissue	0.98583065
63	MP0006276_abnormal_autonomic_nervous	0.98308313
64	MP0003941_abnormal_skin_development	0.97153709
65	MP0005266_abnormal_metabolism	0.95262046
66	MP0005389_reproductive_system_phenotype	0.92872412
67	MP0005076_abnormal_cell_differentiation	0.90600717
68	MP0003718_maternal_effect	0.88647156
69	MP0009379_abnormal_foot_pigmentation	0.88599877
70	MP0002166_altered_tumor_susceptibility	0.88482727
71	MP0002098_abnormal_vibrissa_morphology	0.86379801
72	MP0001191_abnormal_skin_condition	0.82981784
73	MP0005551_abnormal_eye_electrophysiolog	0.80349205
74	MP0004142_abnormal_muscle_tone	0.79292704
75	MP0005387_immune_system_phenotype	0.78738402
76	MP0001790_abnormal_immune_system	0.78738402
77	MP0002075_abnormal_coat/hair_pigmentati	0.77653561
78	MP0002019_abnormal_tumor_incidence	0.76694300
79	MP0002138_abnormal_hepatobiliary_system	0.75955233
80	MP0002733_abnormal_thermal_nociception	0.74934781
81	MP0002136_abnormal_kidney_physiology	0.74927605
82	MP0000367_abnormal_coat/_hair	0.73547986
83	MP0003866_abnormal_defecation	0.73427595
84	MP0002269_muscular_atrophy	0.73160969
85	MP0005464_abnormal_platelet_physiology	0.72980438
86	MP0001119_abnormal_female_reproductive	0.70983689
87	MP0002083_premature_death	0.70269455
88	MP0000685_abnormal_immune_system	0.70241431
89	MP0000566_synostosis	0.68995167
90	MP0010771_integument_phenotype	0.68695060
91	MP0002693_abnormal_pancreas_physiology	0.68360557
92	MP0002938_white_spotting	0.67914040
93	MP0005501_abnormal_skin_physiology	0.67840282
94	MP0001348_abnormal_lacrimal_gland	0.67450626
95	MP0010094_abnormal_chromosome_stability	0.67070154
96	MP0009643_abnormal_urine_homeostasis	0.66081239
97	MP0000678_abnormal_parathyroid_gland	0.65642062
98	MP0000427_abnormal_hair_cycle	0.65096222
99	MP0008961_abnormal_basal_metabolism	0.63268531
100	MP0004924_abnormal_behavior	0.62941200

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	6.03973283
2	Aplastic anemia (HP:0001915)	6.02324081
3	Retinal dysplasia (HP:0007973)	3.75585265
4	IgG deficiency (HP:0004315)	3.67135111
5	Neoplasm of head and neck (HP:0012288)	3.65661412
6	Esophageal neoplasm (HP:0100751)	3.65661412
7	Confusion (HP:0001289)	3.57479607
8	Cutaneous melanoma (HP:0012056)	3.56506511
9	Anomalous pulmonary venous return (HP:0010772)	3.42664095
10	Fibular aplasia (HP:0002990)	3.38056867
11	IgM deficiency (HP:0002850)	3.24833737
12	Elevated erythrocyte sedimentation rate (HP:0003565)	2.89641561
13	Abnormality of the pulmonary veins (HP:0011718)	2.88810489
14	Abnormality of midbrain morphology (HP:0002418)	2.88597538
15	Molar tooth sign on MRI (HP:0002419)	2.88597538
16	Flat occiput (HP:0005469)	2.82994141
17	Abnormal number of erythroid precursors (HP:0012131)	2.81122803
18	Long clavicles (HP:0000890)	2.76910197
19	Abnormality of the intervertebral disk (HP:0005108)	2.70071417
20	Hypoproteinemia (HP:0003075)	2.69485980
21	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.65410527
22	Patellar aplasia (HP:0006443)	2.63543274
23	Hepatocellular necrosis (HP:0001404)	2.62809341
24	Decreased subcutaneous fat (HP:0001002)	2.56132386
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.55320964
26	Abnormality of alanine metabolism (HP:0010916)	2.55320964
27	Hyperalaninemia (HP:0003348)	2.55320964
28	Obstructive sleep apnea (HP:0002870)	2.52553491
29	Abnormal drinking behavior (HP:0030082)	2.48977485
30	Polydipsia (HP:0001959)	2.48977485
31	Aplasia/Hypoplasia of the patella (HP:0006498)	2.46050325
32	Type II lissencephaly (HP:0007260)	2.40405361
33	Palpebral edema (HP:0100540)	2.39340382
34	Cerebral palsy (HP:0100021)	2.38669713
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.38231812
36	Mitochondrial inheritance (HP:0001427)	2.35044203
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.34947761
38	Cerebellar dysplasia (HP:0007033)	2.28182476
39	Encephalitis (HP:0002383)	2.27579681
40	Increased intramyocellular lipid droplets (HP:0012240)	2.27271535
41	Radial bowing (HP:0002986)	2.24194254
42	Abnormal number of incisors (HP:0011064)	2.22647460
43	Congenital stationary night blindness (HP:0007642)	2.22624642
44	Acute necrotizing encephalopathy (HP:0006965)	2.22524799
45	Gastrointestinal stroma tumor (HP:0100723)	2.20820063
46	Hypoplasia of the thymus (HP:0000778)	2.18917044
47	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.16067376
48	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.13742027
49	Abnormality of the renal cortex (HP:0011035)	2.13317526
50	Abnormality of subcutaneous fat tissue (HP:0001001)	2.12949046
51	Hypoplasia of the radius (HP:0002984)	2.12387498
52	Flat capital femoral epiphysis (HP:0003370)	2.11153385
53	Acute lymphatic leukemia (HP:0006721)	2.08648686
54	Unilateral renal agenesis (HP:0000122)	2.08354443
55	Polyuria (HP:0000103)	2.07309715
56	Preauricular skin tag (HP:0000384)	2.07051859
57	Abnormality of the incisor (HP:0000676)	2.04963782
58	Intestinal fistula (HP:0100819)	2.02185107
59	Large eyes (HP:0001090)	2.00726877
60	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.94946802
61	Hepatic necrosis (HP:0002605)	1.91999342
62	Acute myeloid leukemia (HP:0004808)	1.91350821
63	Abnormality of the columella (HP:0009929)	1.91327147
64	Increased CSF lactate (HP:0002490)	1.89986257
65	Long eyelashes (HP:0000527)	1.89954637
66	Abnormality of incisor morphology (HP:0011063)	1.89573746
67	Aplasia involving forearm bones (HP:0009822)	1.87944178
68	Absent forearm bone (HP:0003953)	1.87944178
69	Vertebral fusion (HP:0002948)	1.87635443
70	Entropion (HP:0000621)	1.87490208
71	Orchitis (HP:0100796)	1.84823194
72	Methylmalonic aciduria (HP:0012120)	1.83906861
73	Cerebral hypomyelination (HP:0006808)	1.82612186
74	Myositis (HP:0100614)	1.82333500
75	Ulnar deviation of the wrist (HP:0003049)	1.82197849
76	Skin tags (HP:0010609)	1.81260420
77	Respiratory distress (HP:0002098)	1.80491350
78	Increased muscle lipid content (HP:0009058)	1.80432498
79	Abolished electroretinogram (ERG) (HP:0000550)	1.78794251
80	Retrobulbar optic neuritis (HP:0100654)	1.77965213
81	Optic neuritis (HP:0100653)	1.77965213
82	Thick eyebrow (HP:0000574)	1.77501366
83	Broad-based gait (HP:0002136)	1.75892648
84	Increased serum lactate (HP:0002151)	1.75461938
85	Fused cervical vertebrae (HP:0002949)	1.75203421
86	Poikiloderma (HP:0001029)	1.75038619
87	Autoimmune thrombocytopenia (HP:0001973)	1.74965533
88	Fair hair (HP:0002286)	1.73606459
89	Abnormality of the pons (HP:0007361)	1.73400661
90	Keratoconjunctivitis sicca (HP:0001097)	1.72064977
91	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.70542381
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.70542381
93	Abnormality of dental color (HP:0011073)	1.70539819
94	Action tremor (HP:0002345)	1.67798003
95	Progressive macrocephaly (HP:0004481)	1.65541173
96	Supernumerary bones of the axial skeleton (HP:0009144)	1.65419821
97	Humeroradial synostosis (HP:0003041)	1.65204461
98	Synostosis involving the elbow (HP:0003938)	1.65204461
99	Nephronophthisis (HP:0000090)	1.63517964
100	Pancytopenia (HP:0001876)	1.62938219

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.86030098
2	TESK2	3.88949923
3	KDR	3.44904056
4	INSRR	3.35884031
5	MAP4K1	3.14987669
6	CCNB1	2.90594023
7	BCKDK	2.59463370
8	FLT3	2.38888576
9	DAPK2	2.30424716
10	ACVR1B	2.21757156
11	TXK	2.19169380
12	MAP3K11	2.03670100
13	CSF1R	1.83712905
14	KIT	1.80401856
15	STK38L	1.76689172
16	SCYL2	1.70257952
17	WNK4	1.64323056
18	VRK2	1.56954194
19	CAMK1D	1.47990358
20	NUAK1	1.44732754
21	MAP3K9	1.39513677
22	SYK	1.37617049
23	GRK1	1.33141189
24	PBK	1.31055427
25	PRKCI	1.26023535
26	LIMK1	1.23195811
27	TESK1	1.18992153
28	TYRO3	1.18357805
29	PRKCH	1.17115802
30	VRK1	1.17095102
31	ATR	1.15483837
32	NME1	1.13084559
33	TAF1	1.12946332
34	MAP3K6	1.11770236
35	TNK2	1.09845042
36	LCK	1.04707257
37	DAPK1	0.97653191
38	FES	0.95200341
39	ADRBK2	0.95044055
40	CSK	0.93609498
41	AURKA	0.93139279
42	RIPK4	0.91933008
43	ITK	0.91601315
44	PRKD2	0.90332769
45	STK38	0.89619384
46	ARAF	0.88561808
47	ERN1	0.88153129
48	MELK	0.87612849
49	BMX	0.86348355
50	NME2	0.85666936
51	BRSK2	0.84779899
52	ILK	0.83763200
53	CDK19	0.83545321
54	BTK	0.81431584
55	PIM2	0.81219106
56	FGFR1	0.79631828
57	MAPK11	0.78886449
58	OXSR1	0.70854242
59	ZAP70	0.70124739
60	CHEK2	0.69534911
61	NLK	0.67577663
62	PAK1	0.67538520
63	PDGFRB	0.67161614
64	NTRK3	0.65729799
65	STK39	0.64589830
66	IKBKE	0.64368341
67	ADRBK1	0.62322935
68	HIPK2	0.61813545
69	OBSCN	0.60859750
70	BRSK1	0.57884080
71	PRKCG	0.56879777
72	PHKG2	0.56597931
73	PHKG1	0.56597931
74	CAMKK2	0.55100272
75	CAMK1G	0.51897736
76	GRK6	0.51606708
77	CHEK1	0.51093353
78	MAPK13	0.51043992
79	BMPR1B	0.50375254
80	NEK2	0.48834689
81	GRK7	0.46078538
82	NTRK2	0.42633834
83	MAPK9	0.41909805
84	TEC	0.38898741
85	PRKCD	0.38876506
86	MUSK	0.37668503
87	FYN	0.36582475
88	CDK11A	0.36364857
89	CSNK2A1	0.36346393
90	ABL2	0.35999606
91	PIK3CG	0.35989537
92	RPS6KA5	0.34682255
93	INSR	0.33875976
94	TIE1	0.32621176
95	GSK3B	0.32393709
96	MAPK15	0.32134318
97	PRKACA	0.31702678
98	PRKCA	0.30847876
99	PRKD1	0.30409327
100	CSNK1G3	0.29293533

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.00477955
2	Ribosome_Homo sapiens_hsa03010	3.45611196
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.93140011
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.92843717
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.77857808
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68857355
7	Regulation of autophagy_Homo sapiens_hsa04140	2.62710641
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.56139049
9	Proteasome_Homo sapiens_hsa03050	2.53355124
10	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.45589333
11	Homologous recombination_Homo sapiens_hsa03440	2.38212519
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.11283206
13	Parkinsons disease_Homo sapiens_hsa05012	2.01466045
14	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.98317987
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.92590697
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78356469
17	Base excision repair_Homo sapiens_hsa03410	1.72547576
18	DNA replication_Homo sapiens_hsa03030	1.71930480
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.70929443
20	RNA polymerase_Homo sapiens_hsa03020	1.65749993
21	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.63640311
22	Phototransduction_Homo sapiens_hsa04744	1.62848988
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56972905
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.53222853
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.51301836
26	Huntingtons disease_Homo sapiens_hsa05016	1.51174738
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48849943
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48317341
29	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.43275413
30	Alzheimers disease_Homo sapiens_hsa05010	1.42870951
31	Spliceosome_Homo sapiens_hsa03040	1.40588406
32	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.33854873
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.31571187
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.27973473
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23152138
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.22479091
37	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.19386445
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.18322740
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17733364
40	Basal transcription factors_Homo sapiens_hsa03022	1.13753158
41	One carbon pool by folate_Homo sapiens_hsa00670	1.12553513
42	Purine metabolism_Homo sapiens_hsa00230	1.11075421
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.09981686
44	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.08898512
45	Alcoholism_Homo sapiens_hsa05034	1.02520501
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.99575685
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94163571
48	Lysine degradation_Homo sapiens_hsa00310	0.91390838
49	Protein export_Homo sapiens_hsa03060	0.91078722
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90894440
51	Allograft rejection_Homo sapiens_hsa05330	0.89815741
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.89392420
53	Caffeine metabolism_Homo sapiens_hsa00232	0.86251710
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.85768840
55	Measles_Homo sapiens_hsa05162	0.78011772
56	Sulfur relay system_Homo sapiens_hsa04122	0.77664117
57	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77252170
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75582841
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74711239
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67955223
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67126729
62	RNA transport_Homo sapiens_hsa03013	0.62595089
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60306722
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57656880
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57183460
66	Peroxisome_Homo sapiens_hsa04146	0.56588087
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56300079
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54145701
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53152847
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50395347
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45823415
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45565169
73	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.45557543
74	Cell cycle_Homo sapiens_hsa04110	0.44378200
75	RNA degradation_Homo sapiens_hsa03018	0.44314240
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42300277
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.41402079
78	Herpes simplex infection_Homo sapiens_hsa05168	0.41373187
79	Prion diseases_Homo sapiens_hsa05020	0.39822421
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38388546
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37231472
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.33500179
83	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.31945503
84	p53 signaling pathway_Homo sapiens_hsa04115	0.31853953
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.31718716
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31260379
87	Metabolic pathways_Homo sapiens_hsa01100	0.30670666
88	Morphine addiction_Homo sapiens_hsa05032	0.30255681
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.29832401
90	Olfactory transduction_Homo sapiens_hsa04740	0.28821067
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25844074
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23050788
93	ABC transporters_Homo sapiens_hsa02010	0.22840760
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.22405822
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22392801
96	Taste transduction_Homo sapiens_hsa04742	0.21506829
97	Cholinergic synapse_Homo sapiens_hsa04725	0.21427135
98	Shigellosis_Homo sapiens_hsa05131	0.19215740
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.19064745
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18630514

C1QBPP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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