C1QC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.24456696
2positive regulation by organism of defense response of other organism involved in symbiotic interact7.24456696
3modulation by symbiont of host immune response (GO:0052553)7.24456696
4positive regulation by symbiont of host defense response (GO:0052509)7.24456696
5modulation by symbiont of host defense response (GO:0052031)7.24456696
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.24456696
7microglial cell activation (GO:0001774)6.66210036
8regulation of interferon-beta biosynthetic process (GO:0045357)6.50687727
9macrophage activation involved in immune response (GO:0002281)6.05910704
10positive regulation of chemokine secretion (GO:0090197)5.03310504
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02779623
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.89538394
13mannose metabolic process (GO:0006013)4.82529967
14positive regulation of interferon-alpha production (GO:0032727)4.80891910
15macrophage activation (GO:0042116)4.74139874
16regulation of interferon-alpha production (GO:0032647)4.55316521
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.47488221
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.46536331
19response to host immune response (GO:0052572)4.46536331
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.24483012
21response to host (GO:0075136)4.24483012
22response to host defenses (GO:0052200)4.24483012
23positive regulation of antigen processing and presentation (GO:0002579)4.19001819
24virion attachment to host cell (GO:0019062)4.18675924
25adhesion of symbiont to host cell (GO:0044650)4.18675924
26apoptotic cell clearance (GO:0043277)4.17209463
27regulation of B cell receptor signaling pathway (GO:0050855)4.09908468
28neutrophil activation involved in immune response (GO:0002283)4.04627153
29regulation of macrophage chemotaxis (GO:0010758)4.01357451
30cellular response to thyroid hormone stimulus (GO:0097067)4.01011863
31immunoglobulin mediated immune response (GO:0016064)3.96539931
32response to peptidoglycan (GO:0032494)3.90768200
33amino sugar catabolic process (GO:0046348)3.88624249
34keratan sulfate catabolic process (GO:0042340)3.83049583
35adhesion of symbiont to host (GO:0044406)3.76609262
36cellular extravasation (GO:0045123)3.72575259
37G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.71841604
38T-helper 1 type immune response (GO:0042088)3.70409492
39I-kappaB phosphorylation (GO:0007252)3.69353162
40negative regulation of cell killing (GO:0031342)3.69055077
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69055077
42regulation of chemokine secretion (GO:0090196)3.65306476
43regulation of mononuclear cell migration (GO:0071675)3.64343140
44hyaluronan catabolic process (GO:0030214)3.61841278
45respiratory burst (GO:0045730)3.58846445
46complement activation, alternative pathway (GO:0006957)3.54413918
47myeloid cell activation involved in immune response (GO:0002275)3.53788815
48regulation of apoptotic cell clearance (GO:2000425)3.52466699
49positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52161577
50regulation of antigen processing and presentation (GO:0002577)3.50725280
51pinocytosis (GO:0006907)3.47477945
52negative regulation of interleukin-6 production (GO:0032715)3.44332579
53positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.42921424
54regulation of vitamin D biosynthetic process (GO:0060556)3.40046607
55germinal center formation (GO:0002467)3.38546445
56adenosine receptor signaling pathway (GO:0001973)3.34654103
57N-acetylneuraminate metabolic process (GO:0006054)3.34520301
58barbed-end actin filament capping (GO:0051016)3.34246441
59positive regulation of chemokine biosynthetic process (GO:0045080)3.33920770
60detection of molecule of bacterial origin (GO:0032490)3.31738514
61regulation of interleukin-8 biosynthetic process (GO:0045414)3.31397314
62interferon-gamma-mediated signaling pathway (GO:0060333)3.27282404
63glycosphingolipid catabolic process (GO:0046479)3.24400949
64regulation of cytokine secretion involved in immune response (GO:0002739)3.23750342
65myeloid dendritic cell differentiation (GO:0043011)3.21850999
66monocyte chemotaxis (GO:0002548)3.17265895
67response to thyroid hormone (GO:0097066)3.17110840
68membrane lipid catabolic process (GO:0046466)3.16897628
69negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15409303
70response to muramyl dipeptide (GO:0032495)3.13655243
71positive regulation of cellular amide metabolic process (GO:0034250)3.13403178
72regulation of integrin activation (GO:0033623)3.12726402
73positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.12534664
74positive regulation of interferon-beta production (GO:0032728)3.11242771
75lipoxygenase pathway (GO:0019372)3.10367749
76eosinophil chemotaxis (GO:0048245)3.09462503
77positive regulation of B cell differentiation (GO:0045579)3.08937714
78positive regulation of gamma-delta T cell activation (GO:0046645)3.07279944
79sphingolipid catabolic process (GO:0030149)3.06644538
80NIK/NF-kappaB signaling (GO:0038061)3.06271260
81negative regulation of interleukin-12 production (GO:0032695)3.05830400
82regulation of podosome assembly (GO:0071801)3.05003208
83regulation of vitamin metabolic process (GO:0030656)3.03924039
84positive regulation of heat generation (GO:0031652)3.02791093
85production of molecular mediator involved in inflammatory response (GO:0002532)3.02647057
86negative regulation of cytokine production involved in immune response (GO:0002719)3.02151787
87negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01393567
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99204563
89angiotensin maturation (GO:0002003)2.97998376
90regulation of cholesterol storage (GO:0010885)2.94690794
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93075146
92negative regulation of erythrocyte differentiation (GO:0045647)2.92553914
93lymphocyte chemotaxis (GO:0048247)2.91126352
94myeloid dendritic cell activation (GO:0001773)2.88834496
95regulation of chemokine biosynthetic process (GO:0045073)2.88326541
96regulation of fever generation (GO:0031620)2.88070117
97regulation of phagocytosis (GO:0050764)2.87974190
98glycolipid catabolic process (GO:0019377)2.87142532
99phagocytosis, engulfment (GO:0006911)2.86248660
100positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85744171
101G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.85358089
102regulation of mast cell degranulation (GO:0043304)2.84377351
103regulation of membrane protein ectodomain proteolysis (GO:0051043)2.83881351
104purinergic nucleotide receptor signaling pathway (GO:0035590)2.83419235
105fat-soluble vitamin biosynthetic process (GO:0042362)2.82515934
106detection of external biotic stimulus (GO:0098581)2.82283443
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81608894
108eosinophil migration (GO:0072677)2.81071073
109regulation of hypersensitivity (GO:0002883)2.77576898
110positive regulation of phagocytosis (GO:0050766)2.77260728
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76781413
112detection of other organism (GO:0098543)2.76431318
113positive regulation of cholesterol efflux (GO:0010875)2.74842597
114regulation of T-helper 1 cell differentiation (GO:0045625)2.72681837
115positive regulation of monocyte chemotaxis (GO:0090026)2.72286398
116dendritic cell differentiation (GO:0097028)2.71932212
117myeloid leukocyte activation (GO:0002274)2.71929375
118granulocyte activation (GO:0036230)2.71536414
119response to laminar fluid shear stress (GO:0034616)2.71025695
120positive regulation of mast cell activation (GO:0033005)2.70657819
121cellular response to interferon-gamma (GO:0071346)2.69973422
122hydrogen peroxide biosynthetic process (GO:0050665)2.67835115
123regulation of mast cell activation involved in immune response (GO:0033006)2.67750956
124regulation of interferon-gamma biosynthetic process (GO:0045072)2.67335778
125regulation of inflammatory response to antigenic stimulus (GO:0002861)2.67119646
126* complement activation (GO:0006956)2.64821424
127B cell mediated immunity (GO:0019724)2.64404695
128positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60545352
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60209371
130neutrophil activation (GO:0042119)2.60004613
131positive regulation of chemokine production (GO:0032722)2.59585480
132detection of bacterium (GO:0016045)2.59111556
133cellular response to type I interferon (GO:0071357)2.59086283
134type I interferon signaling pathway (GO:0060337)2.59086283
135low-density lipoprotein particle clearance (GO:0034383)2.57852767
136neutrophil chemotaxis (GO:0030593)2.56792092
137positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.56611823
138adaptation of signaling pathway (GO:0023058)2.55587240
139oligosaccharide catabolic process (GO:0009313)2.53833170
140macrophage differentiation (GO:0030225)2.53830149
141leukotriene metabolic process (GO:0006691)2.53374910
142regulation of leukocyte degranulation (GO:0043300)2.53215491
143ceramide catabolic process (GO:0046514)2.52565236
144positive regulation of lymphocyte migration (GO:2000403)2.52132385
145response to cholesterol (GO:0070723)2.49574287
146neutrophil migration (GO:1990266)2.49102761
147purinergic receptor signaling pathway (GO:0035587)2.48568394
148positive regulation of leukocyte degranulation (GO:0043302)2.48437489
149negative regulation of interleukin-17 production (GO:0032700)2.48143776
150pathway-restricted SMAD protein phosphorylation (GO:0060389)2.47734705
151positive regulation of mast cell degranulation (GO:0043306)2.46237914
152positive regulation of mast cell activation involved in immune response (GO:0033008)2.46237914
153negative regulation of bone resorption (GO:0045779)2.46068513
154adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.46033623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.03134839
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.39337489
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.71507539
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.31106560
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.27606095
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52983203
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.20066595
8* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.15102825
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77805910
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75441785
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70140334
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.49934670
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36792946
14SCL_19346495_ChIP-Seq_HPC-7_Human2.32173524
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31596748
16SPI1_23127762_ChIP-Seq_K562_Human2.29514450
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23069958
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20239580
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13241658
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06964209
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04701152
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02015582
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.01096125
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92862352
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89113683
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87697882
27VDR_24787735_ChIP-Seq_THP-1_Human1.85558779
28VDR_24763502_ChIP-Seq_THP-1_Human1.83658728
29* SPI1_23547873_ChIP-Seq_NB4_Human1.76213486
30VDR_21846776_ChIP-Seq_THP-1_Human1.75799213
31RUNX_20019798_ChIP-Seq_JUKART_Human1.74447589
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72975790
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.71332379
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.70395498
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64619546
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62977504
37PU_27001747_Chip-Seq_BMDM_Mouse1.59315489
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59140948
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56559383
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.54280472
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54076419
42TCF7_22412390_ChIP-Seq_EML_Mouse1.52126998
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48641810
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46570598
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44326669
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43761466
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41899330
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.41663955
49LXR_22292898_ChIP-Seq_THP-1_Human1.41084303
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40032626
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.39465493
52MAF_26560356_Chip-Seq_TH1_Human1.36901349
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35937714
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33820231
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32688788
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29381810
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.28947667
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28347377
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28332316
60GATA1_19941826_ChIP-Seq_K562_Human1.27832248
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26720035
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23060832
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23010500
64KDM2B_26808549_Chip-Seq_DND41_Human1.22819550
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19740297
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19560817
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.17691746
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17606095
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17482180
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16679141
71MYB_26560356_Chip-Seq_TH2_Human1.14942488
72GATA2_19941826_ChIP-Seq_K562_Human1.13725906
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12646567
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10215587
75STAT1_20625510_ChIP-Seq_HELA_Human1.09277425
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09140282
77EGR1_19032775_ChIP-ChIP_M12_Human1.08142866
78KDM2B_26808549_Chip-Seq_K562_Human1.08079283
79SPI1_20517297_ChIP-Seq_HL60_Human1.07261786
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07032669
81CLOCK_20551151_ChIP-Seq_293T_Human1.05774712
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05389496
83BCL6_27268052_Chip-Seq_Bcells_Human1.04789626
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04120652
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02406457
86BCOR_27268052_Chip-Seq_Bcells_Human1.02166203
87RACK7_27058665_Chip-Seq_MCF-7_Human1.02113632
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01534985
89MYC_22102868_ChIP-Seq_BL_Human1.00837180
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00802320
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99020600
92UTX_26944678_Chip-Seq_JUKART_Human0.98714738
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98339633
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.96594929
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95706075
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94973201
97MYB_26560356_Chip-Seq_TH1_Human0.94633621
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.94633186
99GATA1_22025678_ChIP-Seq_K562_Human0.94131475
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93788546
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93488383
102* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89908843
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89726022
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89111780
105GATA3_27048872_Chip-Seq_THYMUS_Human0.89059433
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89008032
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87898355
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87315750
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.86525285
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.85869450
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84632439
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83672984
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80964657
114GATA3_26560356_Chip-Seq_TH2_Human0.80207351
115CJUN_26792858_Chip-Seq_BT549_Human0.74434759
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.74400874
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74389750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.24897688
2MP0003191_abnormal_cellular_cholesterol4.06590494
3MP0009840_abnormal_foam_cell3.94906919
4MP0006082_CNS_inflammation3.88309296
5MP0003303_peritoneal_inflammation3.39228382
6MP0003172_abnormal_lysosome_physiology3.34765792
7MP0001835_abnormal_antigen_presentation3.32788287
8MP0003436_decreased_susceptibility_to3.16469298
9MP0002139_abnormal_hepatobiliary_system2.93564267
10MP0002419_abnormal_innate_immunity2.85690519
11MP0003690_abnormal_glial_cell2.60910961
12MP0002148_abnormal_hypersensitivity_rea2.47825643
13MP0003075_altered_response_to2.41037355
14MP0005000_abnormal_immune_tolerance2.37928997
15MP0005464_abnormal_platelet_physiology2.35194205
16MP0001533_abnormal_skeleton_physiology2.23106779
17MP0001790_abnormal_immune_system2.22770504
18MP0005387_immune_system_phenotype2.22770504
19MP0003724_increased_susceptibility_to2.20166458
20MP0005025_abnormal_response_to2.20072167
21MP0002452_abnormal_antigen_presenting2.12277995
22MP0003300_gastrointestinal_ulcer2.09392953
23MP0008438_abnormal_cutaneous_collagen2.06231723
24MP0004510_myositis1.99302704
25MP0001800_abnormal_humoral_immune1.97246071
26MP0000343_altered_response_to1.95713723
27MP0005671_abnormal_response_to1.93765825
28MP0000604_amyloidosis1.88460603
29MP0000685_abnormal_immune_system1.87484795
30MP0002723_abnormal_immune_serum1.85889327
31MP0009785_altered_susceptibility_to1.78370713
32MP0001819_abnormal_immune_cell1.65780581
33MP0002420_abnormal_adaptive_immunity1.63916949
34MP0008469_abnormal_protein_level1.63016508
35MP0003705_abnormal_hypodermis_morpholog1.60776976
36MP0005451_abnormal_body_composition1.54958306
37MP0001845_abnormal_inflammatory_respons1.54057673
38MP0003329_amyloid_beta_deposits1.51285632
39MP0005166_decreased_susceptibility_to1.50943376
40MP0002405_respiratory_system_inflammati1.47938636
41MP0003183_abnormal_peptide_metabolism1.47449234
42MP0001851_eye_inflammation1.47261048
43MP0004947_skin_inflammation1.44611715
44MP0002998_abnormal_bone_remodeling1.41685787
45MP0003453_abnormal_keratinocyte_physiol1.41270189
46MP0003566_abnormal_cell_adhesion1.37962599
47MP0009278_abnormal_bone_marrow1.36180777
48MP0003806_abnormal_nucleotide_metabolis1.35354670
49MP0005167_abnormal_blood-brain_barrier1.33353172
50MP0009333_abnormal_splenocyte_physiolog1.31955290
51MP0005365_abnormal_bile_salt1.28514669
52MP0008004_abnormal_stomach_pH1.27039497
53MP0000465_gastrointestinal_hemorrhage1.26265869
54MP0001853_heart_inflammation1.24924540
55MP0005310_abnormal_salivary_gland1.22444489
56MP0000689_abnormal_spleen_morphology1.19796741
57MP0005670_abnormal_white_adipose1.18009382
58MP0003448_altered_tumor_morphology1.17483829
59MP0000716_abnormal_immune_system1.16841370
60MP0000249_abnormal_blood_vessel1.14118553
61MP0006054_spinal_hemorrhage1.10669536
62MP0002090_abnormal_vision1.10414042
63MP0002166_altered_tumor_susceptibility1.05619374
64MP0004185_abnormal_adipocyte_glucose1.05133774
65MP0000767_abnormal_smooth_muscle1.04741117
66MP0002254_reproductive_system_inflammat1.03880392
67MP0005390_skeleton_phenotype1.03855166
68MP0001542_abnormal_bone_strength1.03665006
69MP0003195_calcinosis1.03159206
70MP0009764_decreased_sensitivity_to1.00772844
71MP0001915_intracranial_hemorrhage0.99738198
72MP0000609_abnormal_liver_physiology0.99734414
73MP0004130_abnormal_muscle_cell0.99662178
74MP0010155_abnormal_intestine_physiology0.98918057
75MP0003279_aneurysm0.97657206
76MP0009763_increased_sensitivity_to0.97512277
77MP0004883_abnormal_blood_vessel0.94089300
78MP0002398_abnormal_bone_marrow0.94071962
79MP0003252_abnormal_bile_duct0.93199962
80MP0002429_abnormal_blood_cell0.92191178
81MP0010329_abnormal_lipoprotein_level0.91425294
82MP0005023_abnormal_wound_healing0.90899925
83MP0008260_abnormal_autophagy0.90585831
84MP0002933_joint_inflammation0.90005402
85MP0002722_abnormal_immune_system0.89837905
86MP0003828_pulmonary_edema0.87954382
87MP0001663_abnormal_digestive_system0.86870956
88MP0005165_increased_susceptibility_to0.86074666
89MP0003045_fibrosis0.85659244
90MP0005595_abnormal_vascular_smooth0.84980278
91MP0001545_abnormal_hematopoietic_system0.84545522
92MP0005397_hematopoietic_system_phenotyp0.84545522
93MP0005360_urolithiasis0.82388503
94MP0000920_abnormal_myelination0.81608719
95MP0005164_abnormal_response_to0.81050097
96MP0004019_abnormal_vitamin_homeostasis0.80845639
97MP0003656_abnormal_erythrocyte_physiolo0.79870710
98MP0002136_abnormal_kidney_physiology0.77103056
99MP0008873_increased_physiological_sensi0.76729899
100MP0003879_abnormal_hair_cell0.75970799
101MP0000569_abnormal_digit_pigmentation0.74606791
102MP0002332_abnormal_exercise_endurance0.72668638
103MP0005584_abnormal_enzyme/coenzyme_acti0.70818211
104MP0005647_abnormal_sex_gland0.69823731
105MP0003091_abnormal_cell_migration0.69245439
106MP0002138_abnormal_hepatobiliary_system0.68459395
107MP0008874_decreased_physiological_sensi0.68304682
108MP0003634_abnormal_glial_cell0.67679314
109MP0000598_abnormal_liver_morphology0.66216587
110MP0005257_abnormal_intraocular_pressure0.66180253
111MP0002928_abnormal_bile_duct0.65980936
112MP0003633_abnormal_nervous_system0.65701752
113MP0002135_abnormal_kidney_morphology0.65557925
114MP0005666_abnormal_adipose_tissue0.65521536
115MP0003795_abnormal_bone_structure0.65087428
116MP0002006_tumorigenesis0.64803547
117MP0002118_abnormal_lipid_homeostasis0.64719636
118MP0000858_altered_metastatic_potential0.64553233
119MP0004782_abnormal_surfactant_physiolog0.63111006
120MP0001849_ear_inflammation0.62517841
121MP0002896_abnormal_bone_mineralization0.60284613
122MP0002971_abnormal_brown_adipose0.59995946
123MP0005319_abnormal_enzyme/_coenzyme0.58125162

Predicted human phenotypes

RankGene SetZ-score
1* Systemic lupus erythematosus (HP:0002725)9.63408739
2* Glomerulonephritis (HP:0000099)6.97669994
3* Complement deficiency (HP:0004431)5.86597161
4Increased cerebral lipofuscin (HP:0011813)5.85297840
5Abnormality of glycolipid metabolism (HP:0010969)5.78779116
6Abnormality of liposaccharide metabolism (HP:0010968)5.78779116
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.78779116
8Dysostosis multiplex (HP:0000943)5.57101085
9Increased neuronal autofluorescent lipopigment (HP:0002074)5.19205831
10Recurrent abscess formation (HP:0002722)5.18581662
11* Abnormality of complement system (HP:0005339)5.18373478
12Vacuolated lymphocytes (HP:0001922)5.17104746
13Recurrent bacterial skin infections (HP:0005406)4.63448529
14Eczematoid dermatitis (HP:0000976)4.42403697
15Mucopolysacchariduria (HP:0008155)4.31502216
16Urinary glycosaminoglycan excretion (HP:0003541)4.31502216
17Recurrent gram-negative bacterial infections (HP:0005420)4.30992274
18Axonal loss (HP:0003447)4.10605664
19Disinhibition (HP:0000734)4.08223270
20Abnormality of mucopolysaccharide metabolism (HP:0011020)4.06878913
21Abnormality of polysaccharide metabolism (HP:0011012)4.06878913
22Abnormality of glycosaminoglycan metabolism (HP:0004371)4.06878913
23* Nephritis (HP:0000123)3.79861065
24Cerebral aneurysm (HP:0004944)3.62231819
25Mutism (HP:0002300)3.62029830
26Nuclear cataract (HP:0100018)3.55181633
27Arterial tortuosity (HP:0005116)3.42213586
28Abnormality of macrophages (HP:0004311)3.37520690
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.35294190
30Retinal atrophy (HP:0001105)3.27625132
31Loss of speech (HP:0002371)3.25166198
32Asymmetric septal hypertrophy (HP:0001670)3.23597062
33Hematochezia (HP:0002573)3.12981366
34Upper motor neuron abnormality (HP:0002127)3.01524841
35Agnosia (HP:0010524)2.99955139
36Vascular tortuosity (HP:0004948)2.98801224
37Cerebral inclusion bodies (HP:0100314)2.67789767
38Neuronal loss in central nervous system (HP:0002529)2.66302220
39Pathologic fracture (HP:0002756)2.65068710
40Recurrent skin infections (HP:0001581)2.64198114
41Myocardial infarction (HP:0001658)2.62020876
42J-shaped sella turcica (HP:0002680)2.60195673
43Progressive neurologic deterioration (HP:0002344)2.59866513
44Spondylolisthesis (HP:0003302)2.59401198
45Hepatosplenomegaly (HP:0001433)2.56984946
46Thoracic kyphosis (HP:0002942)2.56898892
47Optic neuritis (HP:0100653)2.55641154
48Retrobulbar optic neuritis (HP:0100654)2.55641154
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55314503
50Malnutrition (HP:0004395)2.53443998
51Spontaneous hematomas (HP:0007420)2.53407736
52Colitis (HP:0002583)2.48674916
53Gingivitis (HP:0000230)2.46139414
54Pustule (HP:0200039)2.45092360
55Increased serum ferritin (HP:0003281)2.42363513
56Amyloidosis (HP:0011034)2.41337999
57Abnormality of the lumbar spine (HP:0100712)2.40149368
58Mediastinal lymphadenopathy (HP:0100721)2.31713221
59Elevated erythrocyte sedimentation rate (HP:0003565)2.31117327
60Disproportionate tall stature (HP:0001519)2.29486720
61Myositis (HP:0100614)2.28287495
62Joint stiffness (HP:0001387)2.26509351
63Apathy (HP:0000741)2.25743930
64Aortic aneurysm (HP:0004942)2.21012795
65Diminished motivation (HP:0000745)2.19867265
66Basal ganglia calcification (HP:0002135)2.19823069
67Stomatitis (HP:0010280)2.18313565
68Pulmonary infiltrates (HP:0002113)2.17512218
69Striae distensae (HP:0001065)2.16518846
70Thick nail (HP:0001805)2.15757607
71Chronic obstructive pulmonary disease (HP:0006510)2.15720024
72Obstructive lung disease (HP:0006536)2.15720024
73Peripheral demyelination (HP:0011096)2.14496215
74Metaphyseal irregularity (HP:0003025)2.12541400
75Autoimmune thrombocytopenia (HP:0001973)2.11579729
76Hemoptysis (HP:0002105)2.11088870
77Inappropriate behavior (HP:0000719)2.10047521
78Abnormality of iron homeostasis (HP:0011031)2.07787859
79Neurofibrillary tangles (HP:0002185)2.05537460
80Abnormality of the nasal mucosa (HP:0000433)2.04853966
81Vertebral compression fractures (HP:0002953)2.03643852
82Prolonged neonatal jaundice (HP:0006579)2.03399962
83Inflammation of the large intestine (HP:0002037)2.03018611
84Joint hemorrhage (HP:0005261)2.02540727
85Petechiae (HP:0000967)2.02437822
86Aortic dissection (HP:0002647)2.01707359
87Polygenic inheritance (HP:0010982)2.00763736
88Ovoid vertebral bodies (HP:0003300)1.99603383
89Cardiomegaly (HP:0001640)1.98876773
90Increased CSF protein (HP:0002922)1.97565521
91Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96241553
92Progressive visual loss (HP:0000529)1.94322481
93Cellulitis (HP:0100658)1.93966680
94Recurrent fungal infections (HP:0002841)1.93329412
95Orchitis (HP:0100796)1.93077224
96Interstitial pulmonary disease (HP:0006530)1.91906457
97Supranuclear gaze palsy (HP:0000605)1.91547229
98Memory impairment (HP:0002354)1.91338087
99Periodontitis (HP:0000704)1.89945114
100Dementia (HP:0000726)1.88362531
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.87877439
102Osteolytic defects of the hand bones (HP:0009699)1.87877439
103Vasculitis (HP:0002633)1.86914824
104Gastrointestinal inflammation (HP:0004386)1.86822562
105Bone pain (HP:0002653)1.86137408
106Urethral obstruction (HP:0000796)1.85385446
107Abnormality of the periventricular white matter (HP:0002518)1.85349257
108Deformed sella turcica (HP:0002681)1.85052050
109Polyneuropathy (HP:0001271)1.84654756
110Xanthomatosis (HP:0000991)1.83410732
111Abnormality of the thoracic spine (HP:0100711)1.82307157
112Keratoconjunctivitis sicca (HP:0001097)1.79350657
113Restrictive lung disease (HP:0002091)1.78275825
114Recurrent viral infections (HP:0004429)1.77351690
115Nausea (HP:0002018)1.76436182
116Personality changes (HP:0000751)1.75758371
117Meningitis (HP:0001287)1.75216251
118Conjunctival telangiectasia (HP:0000524)1.73422950
119Gastrointestinal stroma tumor (HP:0100723)1.72264313
120Deep venous thrombosis (HP:0002625)1.72049681
121Urticaria (HP:0001025)1.70643827
122Global brain atrophy (HP:0002283)1.69271402
123Premature loss of primary teeth (HP:0006323)1.69039939
124Purpura (HP:0000979)1.68781462
125Pulmonary embolism (HP:0002204)1.68087983
126Thin bony cortex (HP:0002753)1.65257795
127Peritonitis (HP:0002586)1.65121822
128Bone cyst (HP:0012062)1.63533863
129Arterial thrombosis (HP:0004420)1.63165992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.05249209
2BLK4.40975255
3ERN13.24548190
4TYK23.23848143
5NME23.10049008
6CSF1R2.89996380
7CAMK1D2.80707089
8DDR22.78570842
9GRK72.66627736
10MAPK152.56322071
11TBK12.51836113
12RIPK42.45929664
13IRAK42.20650597
14CAMK1G2.06725769
15TRIB32.03961492
16TAOK22.01277325
17MAP4K12.00266010
18PRPF4B1.92427467
19ACVR1B1.84396001
20IRAK31.83510491
21KIT1.80676952
22CDC42BPA1.76155878
23EPHB11.75996284
24PKN21.75675508
25PAK41.74777893
26JAK11.71801467
27TAOK11.68060693
28MAP3K141.54224354
29ZAP701.53146336
30MST1R1.52443768
31MAP2K31.47634171
32PIM21.47327987
33FES1.45392722
34CAMKK21.44824883
35HCK1.42696022
36ABL21.41970783
37CSK1.40593341
38RIPK11.38443055
39STK101.35851357
40TESK11.23264919
41CAMKK11.20221572
42NEK91.19438332
43IKBKB1.18853222
44JAK21.17340331
45PTK61.16084351
46MATK1.15115569
47SCYL21.10509321
48CLK11.08239265
49IKBKE1.07397142
50FGR1.04306001
51EPHB20.95626836
52LCK0.95027723
53SYK0.94784128
54MOS0.94762544
55TESK20.94752390
56LYN0.94341370
57TAOK30.92078895
58TSSK60.90933678
59MAP3K30.89418521
60MAP3K130.88419344
61PDGFRA0.87075386
62MAPK120.85296393
63EPHA30.81532745
64TTN0.80006437
65BTK0.77007913
66SIK20.72717069
67BMX0.69793370
68TGFBR10.69474159
69BMPR20.68672036
70TYRO30.68343856
71TXK0.68146075
72CDK60.67019751
73PRKG20.64372779
74JAK30.64345590
75MAP3K100.64063443
76MAP2K60.63787429
77EGFR0.63751574
78IRAK10.63395171
79PDK20.62933576
80DAPK20.62447818
81IGF1R0.62027462
82MAP3K110.61671314
83ITK0.59650627
84ICK0.59392048
85MAP3K50.59066902
86IRAK20.56895708
87FGFR40.56648462
88TNK20.55597334
89PDK10.55472953
90PAK20.53651819
91PDPK10.53586273
92MARK30.53156942
93PIK3CG0.52852156
94MAPKAPK20.51551846
95RPS6KA40.50039893
96CAMK40.48395172
97ARAF0.47140880
98GSK3A0.46383627
99GRK50.44369803
100PRKCD0.43033803
101EEF2K0.42987131
102ADRBK20.42889324
103FYN0.41686497
104LRRK20.41521168
105GRK60.41055432
106RPS6KA20.39362451
107SIK30.39344448
108LIMK10.39242049
109MARK20.39114187
110MAP3K90.37947645
111FGFR30.37523513
112PDGFRB0.36730412
113ABL10.36714886
114PRKCH0.36058038
115CHUK0.35801984
116PRKAA20.35547833
117HIPK20.33104491
118MAP3K10.33015019
119PTK2B0.32653960
120RPS6KA60.32596928
121MAPK70.32279404
122MAPKAPK30.32027585
123MAPK40.31899944
124DMPK0.30494857
125LATS20.30448005
126RET0.29904054
127INSR0.29532120
128SIK10.29480259
129TEC0.29001286
130PRKD10.28601671
131PIM10.27948993
132DAPK30.27537790
133RPS6KL10.27340965
134RPS6KC10.27340965
135MET0.25789560

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051505.89489348
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.74089362
3Other glycan degradation_Homo sapiens_hsa005114.60245441
4Lysosome_Homo sapiens_hsa041423.44447003
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.63552214
6Leishmaniasis_Homo sapiens_hsa051402.54257795
7* Complement and coagulation cascades_Homo sapiens_hsa046102.53731703
8Osteoclast differentiation_Homo sapiens_hsa043802.49071113
9* Pertussis_Homo sapiens_hsa051332.43309812
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39028624
11Autoimmune thyroid disease_Homo sapiens_hsa053202.16220344
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94984805
13Tuberculosis_Homo sapiens_hsa051521.81447931
14* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72578177
15Type I diabetes mellitus_Homo sapiens_hsa049401.71319203
16* Prion diseases_Homo sapiens_hsa050201.66858173
17B cell receptor signaling pathway_Homo sapiens_hsa046621.66545914
18Legionellosis_Homo sapiens_hsa051341.56189709
19Malaria_Homo sapiens_hsa051441.56037033
20Antigen processing and presentation_Homo sapiens_hsa046121.55259250
21Phagosome_Homo sapiens_hsa041451.51828663
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50570607
23Nitrogen metabolism_Homo sapiens_hsa009101.49005906
24Toxoplasmosis_Homo sapiens_hsa051451.35237963
25Caffeine metabolism_Homo sapiens_hsa002321.26993819
26Chemokine signaling pathway_Homo sapiens_hsa040621.15852352
27Salmonella infection_Homo sapiens_hsa051321.12934744
28Rheumatoid arthritis_Homo sapiens_hsa053231.08822590
29Measles_Homo sapiens_hsa051621.08140624
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07014016
31Collecting duct acid secretion_Homo sapiens_hsa049661.04908749
32Influenza A_Homo sapiens_hsa051641.01103208
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98715540
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97835847
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.97388279
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93764966
37Hematopoietic cell lineage_Homo sapiens_hsa046400.93144593
38Amoebiasis_Homo sapiens_hsa051460.85811214
39Leukocyte transendothelial migration_Homo sapiens_hsa046700.84216081
40Endocytosis_Homo sapiens_hsa041440.83967408
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81561751
42Platelet activation_Homo sapiens_hsa046110.78385198
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77723654
44Shigellosis_Homo sapiens_hsa051310.77627390
45Galactose metabolism_Homo sapiens_hsa000520.76702745
46Apoptosis_Homo sapiens_hsa042100.76070440
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74718664
48Pancreatic cancer_Homo sapiens_hsa052120.74202139
49Chronic myeloid leukemia_Homo sapiens_hsa052200.73737506
50ABC transporters_Homo sapiens_hsa020100.73036843
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72901061
52TNF signaling pathway_Homo sapiens_hsa046680.71380306
53Vibrio cholerae infection_Homo sapiens_hsa051100.71085874
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.67568803
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66796763
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66396007
57Sulfur metabolism_Homo sapiens_hsa009200.65327561
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63176363
59Bladder cancer_Homo sapiens_hsa052190.62360844
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.60861433
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.60656343
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59728632
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58925618
64Hepatitis B_Homo sapiens_hsa051610.57833919
65Fructose and mannose metabolism_Homo sapiens_hsa000510.57480531
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.54035368
67Arachidonic acid metabolism_Homo sapiens_hsa005900.52108451
68PPAR signaling pathway_Homo sapiens_hsa033200.50457683
69Hepatitis C_Homo sapiens_hsa051600.48880541
70Renal cell carcinoma_Homo sapiens_hsa052110.48868385
71Acute myeloid leukemia_Homo sapiens_hsa052210.48279646
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47661573
73African trypanosomiasis_Homo sapiens_hsa051430.46309263
74Arginine biosynthesis_Homo sapiens_hsa002200.45715908
75Tryptophan metabolism_Homo sapiens_hsa003800.45373103
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.44690009
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44290308
78Sphingolipid metabolism_Homo sapiens_hsa006000.44088412
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.43878209
80Herpes simplex infection_Homo sapiens_hsa051680.43461206
81Notch signaling pathway_Homo sapiens_hsa043300.41544629
82Viral myocarditis_Homo sapiens_hsa054160.41453190
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39826124
84Primary immunodeficiency_Homo sapiens_hsa053400.38305981
85* Systemic lupus erythematosus_Homo sapiens_hsa053220.37583272
86Asthma_Homo sapiens_hsa053100.36591218
87Insulin resistance_Homo sapiens_hsa049310.34104393
88Proteoglycans in cancer_Homo sapiens_hsa052050.33822015
89Mineral absorption_Homo sapiens_hsa049780.33248326
90T cell receptor signaling pathway_Homo sapiens_hsa046600.33237327
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31898101
92Colorectal cancer_Homo sapiens_hsa052100.31627774
93VEGF signaling pathway_Homo sapiens_hsa043700.31274944
94Epstein-Barr virus infection_Homo sapiens_hsa051690.29687476
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.29437059
96Adherens junction_Homo sapiens_hsa045200.28736757
97Type II diabetes mellitus_Homo sapiens_hsa049300.28271848
98Glutathione metabolism_Homo sapiens_hsa004800.28247299
99Graft-versus-host disease_Homo sapiens_hsa053320.27399476
100Rap1 signaling pathway_Homo sapiens_hsa040150.27379584
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27300537
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26694563
103Focal adhesion_Homo sapiens_hsa045100.26277845
104HIF-1 signaling pathway_Homo sapiens_hsa040660.26151423
105Synaptic vesicle cycle_Homo sapiens_hsa047210.24867126
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.24141969
107Renin-angiotensin system_Homo sapiens_hsa046140.22869142
108GnRH signaling pathway_Homo sapiens_hsa049120.22853939
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22518057
110Vitamin digestion and absorption_Homo sapiens_hsa049770.22134956
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21555463
112Ether lipid metabolism_Homo sapiens_hsa005650.20886986
113Prolactin signaling pathway_Homo sapiens_hsa049170.20813146
114MAPK signaling pathway_Homo sapiens_hsa040100.20313792
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20284460
116Allograft rejection_Homo sapiens_hsa053300.19970448
117HTLV-I infection_Homo sapiens_hsa051660.19244925
118Starch and sucrose metabolism_Homo sapiens_hsa005000.19056788
119Histidine metabolism_Homo sapiens_hsa003400.16254586
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15989643
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15871525

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »