C1QL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drinking behavior (GO:0042756)6.10128112
2maturation of SSU-rRNA (GO:0030490)5.82690318
3cell migration in hindbrain (GO:0021535)5.78943893
4negative regulation of cell size (GO:0045792)5.53352376
5ribosomal small subunit biogenesis (GO:0042274)5.02110983
6postsynaptic membrane organization (GO:0001941)4.99004617
7acrosome reaction (GO:0007340)4.90148443
8N-acetylneuraminate metabolic process (GO:0006054)4.84751037
9viral transcription (GO:0019083)4.84269786
10translational termination (GO:0006415)4.76636588
11cranial nerve morphogenesis (GO:0021602)4.74057243
12detection of temperature stimulus involved in sensory perception (GO:0050961)4.73987368
13detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.73987368
14pyrimidine nucleobase catabolic process (GO:0006208)4.56596428
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54589997
16negative regulation of appetite (GO:0032099)4.42922405
17negative regulation of response to food (GO:0032096)4.42922405
18positive regulation of vascular permeability (GO:0043117)4.39081251
19protein neddylation (GO:0045116)4.36044636
20negative regulation of digestive system process (GO:0060457)4.35135019
21negative regulation of microtubule polymerization (GO:0031115)4.22263258
22peripheral nervous system neuron development (GO:0048935)4.20058239
23peptidyl-arginine omega-N-methylation (GO:0035247)4.18861700
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17178144
25ATP synthesis coupled proton transport (GO:0015986)4.17178144
26cell-cell junction maintenance (GO:0045217)3.97212720
27detection of temperature stimulus (GO:0016048)3.92516837
28translational elongation (GO:0006414)3.90633413
29cellular protein complex disassembly (GO:0043624)3.87722421
30peroxisome fission (GO:0016559)3.87477369
31neuronal action potential propagation (GO:0019227)3.87292776
32translational initiation (GO:0006413)3.84184603
33regulation of feeding behavior (GO:0060259)3.84029621
34lung-associated mesenchyme development (GO:0060484)3.82306410
35viral life cycle (GO:0019058)3.80564293
36ribosomal large subunit biogenesis (GO:0042273)3.75829185
37negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.69915309
38dendritic spine morphogenesis (GO:0060997)3.66343295
39negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.65545227
40peptidyl-arginine methylation (GO:0018216)3.65074518
41peptidyl-arginine N-methylation (GO:0035246)3.65074518
42DNA damage response, detection of DNA damage (GO:0042769)3.64697030
43negative regulation of necrotic cell death (GO:0060547)3.64273511
44retinal ganglion cell axon guidance (GO:0031290)3.62090010
45hemidesmosome assembly (GO:0031581)3.61886268
46regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.59144048
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57282635
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53265138
49regulation of response to food (GO:0032095)3.53140281
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52872139
51cotranslational protein targeting to membrane (GO:0006613)3.50538282
52protein targeting to ER (GO:0045047)3.49073978
53negative regulation of catenin import into nucleus (GO:0035414)3.48091913
54activation of protein kinase A activity (GO:0034199)3.46546756
55cochlea morphogenesis (GO:0090103)3.46356731
56nucleobase catabolic process (GO:0046113)3.42020289
57establishment of mitochondrion localization (GO:0051654)3.41539419
58mitochondrion transport along microtubule (GO:0047497)3.38877679
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.38877679
60kidney mesenchyme development (GO:0072074)3.36718044
61morphogenesis of an epithelial fold (GO:0060571)3.36389319
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35980874
63sperm motility (GO:0030317)3.31348960
64CDP-diacylglycerol metabolic process (GO:0046341)3.30846529
65protein complex disassembly (GO:0043241)3.28695447
66respiratory electron transport chain (GO:0022904)3.26885913
67protein localization to synapse (GO:0035418)3.23636389
68outer ear morphogenesis (GO:0042473)3.23535450
69protein localization to endoplasmic reticulum (GO:0070972)3.23349500
70positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.22290538
71regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.22290538
72alpha-linolenic acid metabolic process (GO:0036109)3.20577687
73amino sugar catabolic process (GO:0046348)3.19351903
74positive regulation of gastrulation (GO:2000543)3.19263552
75response to pain (GO:0048265)3.19184492
76planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17303689
77macromolecular complex disassembly (GO:0032984)3.16890757
78electron transport chain (GO:0022900)3.16187630
79microtubule depolymerization (GO:0007019)3.14828683
80metanephric mesenchyme development (GO:0072075)3.14648405
81axon extension (GO:0048675)3.14369608
82regulation of mesenchymal cell apoptotic process (GO:2001053)3.13481526
83skeletal muscle organ development (GO:0060538)3.07982261
84histone arginine methylation (GO:0034969)3.07276556
85presynaptic membrane assembly (GO:0097105)3.03272437
86regulation of mitochondrial translation (GO:0070129)3.02930766
87protein maturation by protein folding (GO:0022417)3.01969228
88axonal fasciculation (GO:0007413)3.01526159
89regulation of cellular amino acid metabolic process (GO:0006521)3.01362486
90urogenital system development (GO:0001655)2.99315390
91regulation of synapse structural plasticity (GO:0051823)2.98826400
92regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98552460
93mating behavior (GO:0007617)2.97810606
94neuron cell-cell adhesion (GO:0007158)2.96805230
95cell junction maintenance (GO:0034331)2.94506141
96regulation of respiratory system process (GO:0044065)2.93586568
97axonemal dynein complex assembly (GO:0070286)2.93429425
98pattern specification involved in kidney development (GO:0061004)2.92240641
99GTP biosynthetic process (GO:0006183)2.91324038
100membrane budding (GO:0006900)2.89402973
101dendritic spine organization (GO:0097061)2.88110765
102behavioral response to nicotine (GO:0035095)2.87952268
103embryonic viscerocranium morphogenesis (GO:0048703)2.85319096
104motor neuron axon guidance (GO:0008045)2.85129056
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83387219
106chromosome condensation (GO:0030261)2.82263570
107response to pheromone (GO:0019236)2.81861813
108GMP metabolic process (GO:0046037)2.81778656
109locomotory exploration behavior (GO:0035641)2.81155197
110negative regulation of cation channel activity (GO:2001258)2.80771764
111regulation of appetite (GO:0032098)2.80322869
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79770061
113UTP biosynthetic process (GO:0006228)2.79178988
114CDP-diacylglycerol biosynthetic process (GO:0016024)2.78826521
115cerebellar Purkinje cell layer development (GO:0021680)2.78692285
116protein-DNA complex disassembly (GO:0032986)2.78596074
117nucleosome disassembly (GO:0006337)2.78596074
118regulation of respiratory gaseous exchange (GO:0043576)2.77941702
119muscle cell fate commitment (GO:0042693)2.77677204
120presynaptic membrane organization (GO:0097090)2.76952767
121response to dietary excess (GO:0002021)2.76666362
122negative regulation of cell aging (GO:0090344)2.76482227
123calcium-mediated signaling using intracellular calcium source (GO:0035584)2.75981107
124positive regulation of synapse assembly (GO:0051965)2.73178869
125neuron recognition (GO:0008038)2.73006848
126fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72286385
127negative regulation of cell fate commitment (GO:0010454)2.72198699
128formation of translation preinitiation complex (GO:0001731)2.72076988
129cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71944072
130dicarboxylic acid catabolic process (GO:0043649)2.70942820
131neurofilament cytoskeleton organization (GO:0060052)2.70096955
132regulation of G0 to G1 transition (GO:0070316)2.69124020
133generation of neurons (GO:0048699)2.68135410
134translation (GO:0006412)2.67685391
135DNA packaging (GO:0006323)2.67485575
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.66208690
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65513142
138positive regulation of skeletal muscle tissue development (GO:0048643)2.65503767
139response to water (GO:0009415)2.64493947
140outflow tract septum morphogenesis (GO:0003148)2.64364107
141middle ear morphogenesis (GO:0042474)2.64254427
142RNA localization (GO:0006403)2.64120035
143axon regeneration (GO:0031103)2.63629945
144negative regulation of response to extracellular stimulus (GO:0032105)2.62804036
145negative regulation of response to nutrient levels (GO:0032108)2.62804036
146lymph vessel development (GO:0001945)2.62455767
147proteasome assembly (GO:0043248)2.62207863
148regulation of NFAT protein import into nucleus (GO:0051532)2.61888195
149respiratory system process (GO:0003016)2.60693704
150neuromuscular synaptic transmission (GO:0007274)2.60167310
151positive regulation of axonogenesis (GO:0050772)2.59966754
152exploration behavior (GO:0035640)2.58021721
153microtubule severing (GO:0051013)2.57756690
154neuron projection extension (GO:1990138)2.57601887
155regulation of protein kinase A signaling (GO:0010738)2.57379523
156central nervous system projection neuron axonogenesis (GO:0021952)2.56409432
157positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55791257
158microtubule polymerization or depolymerization (GO:0031109)2.54015126
159calcium ion-dependent exocytosis (GO:0017156)2.52990437
160fusion of sperm to egg plasma membrane (GO:0007342)2.52184022
161protein targeting to membrane (GO:0006612)2.51896678
162sperm capacitation (GO:0048240)2.51395366
163transcription elongation from RNA polymerase I promoter (GO:0006362)2.50278127
164centriole assembly (GO:0098534)2.50240603
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48186340
166cellular component maintenance (GO:0043954)2.47967252
167embryonic skeletal joint morphogenesis (GO:0060272)2.47772912
168arginine metabolic process (GO:0006525)2.47185257
169SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.46853165
170dorsal/ventral neural tube patterning (GO:0021904)2.46253438
171spermatid development (GO:0007286)2.46239609
172response to misfolded protein (GO:0051788)2.45875075
173regulation of cellular amine metabolic process (GO:0033238)2.45306729
174motile cilium assembly (GO:0044458)2.44700889
175DNA strand renaturation (GO:0000733)2.43895601
176spermatid nucleus differentiation (GO:0007289)2.41485691
177positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.41120769
178cellular response to ATP (GO:0071318)2.40984353
179spinal cord development (GO:0021510)2.40657515
180diaphragm development (GO:0060539)2.39867104
181regulation of cardioblast proliferation (GO:0003264)2.39616282
182regulation of secondary heart field cardioblast proliferation (GO:0003266)2.39616282
183dendrite morphogenesis (GO:0048813)2.39495222
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.35670686
185layer formation in cerebral cortex (GO:0021819)2.35285498
186auditory behavior (GO:0031223)2.34477535
187response to acidic pH (GO:0010447)2.33977284
188convergent extension (GO:0060026)2.33415885
189regulation of microtubule-based movement (GO:0060632)2.33217236
190GDP-mannose metabolic process (GO:0019673)2.33185675
191ionotropic glutamate receptor signaling pathway (GO:0035235)2.32800277
192camera-type eye morphogenesis (GO:0048593)2.32709627
193rRNA methylation (GO:0031167)2.32168997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58498831
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.29977167
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.00373070
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.87190808
5ZNF263_19887448_ChIP-Seq_K562_Human3.78235864
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.53925484
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.13252952
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.77863779
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.66847210
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59604939
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.59360427
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47534364
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37673424
14LXR_22292898_ChIP-Seq_THP-1_Human2.35304217
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28378978
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28378978
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24885079
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20737881
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20462886
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12138124
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10335954
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.10280414
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97880845
24* TET1_21451524_ChIP-Seq_MESCs_Mouse1.97194532
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94504668
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91913153
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89327493
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88118040
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86302151
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.86263780
31* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.85566472
32P68_20966046_ChIP-Seq_HELA_Human1.85353313
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.81725487
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.80569681
35* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80250152
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.79371832
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77821347
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77731953
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71118003
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.70728126
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.69861024
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69220348
43KDM2B_26808549_Chip-Seq_K562_Human1.68355973
44MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.64123679
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64047765
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61996196
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61759758
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61169372
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.60110831
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59318304
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.58691313
52TAF15_26573619_Chip-Seq_HEK293_Human1.58625036
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58409502
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58213396
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57127689
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56407091
57CTCF_27219007_Chip-Seq_Bcells_Human1.56287001
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54756387
59SMC4_20622854_ChIP-Seq_HELA_Human1.54266776
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.52533902
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.51492669
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48171945
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47828690
64REST_21632747_ChIP-Seq_MESCs_Mouse1.47057442
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46171854
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44854755
67TTF2_22483619_ChIP-Seq_HELA_Human1.44500662
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43290852
69* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41929170
70* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41356070
71* ELF1_20517297_ChIP-Seq_JURKAT_Human1.40366445
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39755398
73OCT4_18692474_ChIP-Seq_MEFs_Mouse1.38976851
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.37819707
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.37794518
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36891370
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35604529
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35403382
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.35003625
80* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34138533
81RACK7_27058665_Chip-Seq_MCF-7_Human1.33278475
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32441215
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.31022513
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30325591
85VDR_21846776_ChIP-Seq_THP-1_Human1.30295129
86* PHF8_20622854_ChIP-Seq_HELA_Human1.30293881
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29312404
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29204072
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27634713
90* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26877265
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26389345
92RNF2_27304074_Chip-Seq_NSC_Mouse1.26069870
93TP53_22127205_ChIP-Seq_IMR90_Human1.25907373
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25546944
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24927659
96* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24896334
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24158999
98* E2F1_20622854_ChIP-Seq_HELA_Human1.23845150
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23607512
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.23515773
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23464475
102* BCL6_27268052_Chip-Seq_Bcells_Human1.22476826
103NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22330921
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22038264
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21853419
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.21762975
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21402655
108AR_21572438_ChIP-Seq_LNCaP_Human1.21317374
109* RARA_24833708_ChIP-Seq_LIVER_Mouse1.20577920
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19457248
111CTCF_20526341_ChIP-Seq_ESCs_Human1.18572449
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18225918
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18034595
114CREB1_26743006_Chip-Seq_LNCaP_Human1.17670512
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14256637
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13610823
117KDM2B_26808549_Chip-Seq_DND41_Human1.13114600
118* BCOR_27268052_Chip-Seq_Bcells_Human1.12855768
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12104633
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11465516
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11066039
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11061824
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10865880
124* CTCF_21964334_Chip-Seq_Bcells_Human1.10428264
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09275096
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07770399
127MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07723269
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07321713
129XRN2_22483619_ChIP-Seq_HELA_Human1.07282279
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06787471
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06387016
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06157188
133IRF1_19129219_ChIP-ChIP_H3396_Human1.05610017
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05364096
135ERA_21632823_ChIP-Seq_H3396_Human1.05313972
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04731997
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04599017
138* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04397499
139SA1_27219007_Chip-Seq_Bcells_Human1.03939011
140GATA1_26923725_Chip-Seq_HPCs_Mouse1.03643411
141SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03639385
142TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01764871
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00336157
144BCAT_22108803_ChIP-Seq_LS180_Human0.96999082
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.96025626
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95252283
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94377219
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94103417
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91776423
150JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91271995
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89561885
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88908213
153MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86543609
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84446573
155POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83411006
156* TET1_21490601_ChIP-Seq_MESCs_Mouse0.83237388
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82594325
158UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80654964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception3.78530678
2MP0009379_abnormal_foot_pigmentation3.69018607
3MP0002102_abnormal_ear_morphology3.55690919
4MP0003136_yellow_coat_color3.09548128
5MP0002734_abnormal_mechanical_nocicepti3.01191500
6MP0005171_absent_coat_pigmentation2.95474267
7MP0001968_abnormal_touch/_nociception2.93475215
8MP0000537_abnormal_urethra_morphology2.87977328
9MP0003693_abnormal_embryo_hatching2.82335810
10MP0002184_abnormal_innervation2.74666053
11MP0006276_abnormal_autonomic_nervous2.59686618
12MP0002736_abnormal_nociception_after2.58994847
13MP0004270_analgesia2.56243409
14MP0000778_abnormal_nervous_system2.48231862
15MP0002733_abnormal_thermal_nociception2.44861326
16MP0004859_abnormal_synaptic_plasticity2.42846355
17MP0004145_abnormal_muscle_electrophysio2.36230038
18MP0002822_catalepsy2.35274276
19MP0001502_abnormal_circadian_rhythm2.33782018
20MP0008004_abnormal_stomach_pH2.33483410
21MP0001188_hyperpigmentation2.28107441
22MP0001970_abnormal_pain_threshold2.27899533
23MP0010030_abnormal_orbit_morphology2.20192132
24MP0005410_abnormal_fertilization2.19622816
25MP0001727_abnormal_embryo_implantation2.16790403
26MP0001486_abnormal_startle_reflex2.05777274
27MP0003880_abnormal_central_pattern2.03032470
28MP0002234_abnormal_pharynx_morphology1.98501100
29MP0004858_abnormal_nervous_system1.98277865
30MP0000049_abnormal_middle_ear1.92855329
31MP0002751_abnormal_autonomic_nervous1.89773880
32MP0002282_abnormal_trachea_morphology1.81087171
33MP0008932_abnormal_embryonic_tissue1.80998018
34MP0001348_abnormal_lacrimal_gland1.77000027
35MP0003938_abnormal_ear_development1.68024046
36MP0004019_abnormal_vitamin_homeostasis1.67727862
37MP0004883_abnormal_blood_vessel1.62509123
38MP0000955_abnormal_spinal_cord1.60671303
39MP0003315_abnormal_perineum_morphology1.57399449
40MP0005409_darkened_coat_color1.54908984
41MP0005423_abnormal_somatic_nervous1.51012046
42MP0003283_abnormal_digestive_organ1.51010907
43MP0004133_heterotaxia1.47783041
44MP0002752_abnormal_somatic_nervous1.45434534
45MP0003698_abnormal_male_reproductive1.45389445
46MP0003890_abnormal_embryonic-extraembry1.45146790
47MP0005174_abnormal_tail_pigmentation1.41284681
48MP0000566_synostosis1.37648946
49MP0008995_early_reproductive_senescence1.34901046
50MP0003011_delayed_dark_adaptation1.33573195
51MP0005623_abnormal_meninges_morphology1.33129963
52MP0001346_abnormal_lacrimal_gland1.32667178
53MP0001986_abnormal_taste_sensitivity1.32332744
54MP0003942_abnormal_urinary_system1.32280995
55MP0002067_abnormal_sensory_capabilities1.30797726
56MP0003635_abnormal_synaptic_transmissio1.30250089
57MP0008789_abnormal_olfactory_epithelium1.24414919
58MP0001299_abnormal_eye_distance/1.23514923
59MP0002557_abnormal_social/conspecific_i1.23230263
60MP0005394_taste/olfaction_phenotype1.21957447
61MP0005499_abnormal_olfactory_system1.21957447
62MP0003119_abnormal_digestive_system1.21209131
63MP0005083_abnormal_biliary_tract1.19643960
64MP0002882_abnormal_neuron_morphology1.18921363
65MP0000427_abnormal_hair_cycle1.18315515
66MP0002572_abnormal_emotion/affect_behav1.17698630
67MP0003121_genomic_imprinting1.17068268
68MP0005187_abnormal_penis_morphology1.16559183
69MP0001963_abnormal_hearing_physiology1.16070111
70MP0000751_myopathy1.14524381
71MP0002928_abnormal_bile_duct1.14276591
72MP0001929_abnormal_gametogenesis1.08245693
73MP0002697_abnormal_eye_size1.07687875
74MP0005360_urolithiasis1.07387556
75MP0003385_abnormal_body_wall1.07041268
76MP0004957_abnormal_blastocyst_morpholog1.06484626
77MP0003195_calcinosis1.05853645
78MP0002249_abnormal_larynx_morphology1.05660898
79MP0001849_ear_inflammation1.05284542
80MP0006292_abnormal_olfactory_placode1.02290710
81MP0009250_abnormal_appendicular_skeleto1.02217856
82MP0000003_abnormal_adipose_tissue1.00749874
83MP0003329_amyloid_beta_deposits1.00561853
84MP0002161_abnormal_fertility/fecundity1.00152471
85MP0008260_abnormal_autophagy0.99996784
86MP0002063_abnormal_learning/memory/cond0.99714566
87MP0000534_abnormal_ureter_morphology0.99397969
88MP0005257_abnormal_intraocular_pressure0.99134179
89MP0003755_abnormal_palate_morphology0.98391525
90MP0002638_abnormal_pupillary_reflex0.98214489
91MP0005377_hearing/vestibular/ear_phenot0.98213083
92MP0003878_abnormal_ear_physiology0.98213083
93MP0002064_seizures0.97985978
94MP0003861_abnormal_nervous_system0.97802687
95MP0002210_abnormal_sex_determination0.96850641
96MP0005085_abnormal_gallbladder_physiolo0.96460717
97MP0002081_perinatal_lethality0.95221949
98MP0000631_abnormal_neuroendocrine_gland0.94709043
99MP0003567_abnormal_fetal_cardiomyocyte0.93969915
100MP0001440_abnormal_grooming_behavior0.93340691
101MP0003868_abnormal_feces_composition0.91688546
102MP0000026_abnormal_inner_ear0.91357924
103MP0009745_abnormal_behavioral_response0.91293394
104MP0003634_abnormal_glial_cell0.90629011
105MP0008961_abnormal_basal_metabolism0.90337701
106MP0003077_abnormal_cell_cycle0.90180469
107MP0001984_abnormal_olfaction0.88985583
108MP0001529_abnormal_vocalization0.87748491
109MP0000762_abnormal_tongue_morphology0.86899245
110MP0001286_abnormal_eye_development0.86887473
111MP0000750_abnormal_muscle_regeneration0.86669983
112MP0004130_abnormal_muscle_cell0.86634712
113MP0002116_abnormal_craniofacial_bone0.85235640
114MP0003123_paternal_imprinting0.84817295
115MP0009053_abnormal_anal_canal0.84719391
116MP0004811_abnormal_neuron_physiology0.84492347
117MP0002066_abnormal_motor_capabilities/c0.84378631
118MP0004742_abnormal_vestibular_system0.84303883
119MP0000733_abnormal_muscle_development0.83946113
120MP0003718_maternal_effect0.83646195
121MP0002932_abnormal_joint_morphology0.82033329
122MP0002152_abnormal_brain_morphology0.81801258
123MP0003137_abnormal_impulse_conducting0.81770257
124MP0003111_abnormal_nucleus_morphology0.78886879
125MP0010770_preweaning_lethality0.78288565
126MP0002082_postnatal_lethality0.78288565
127MP0000747_muscle_weakness0.77043630
128MP0010769_abnormal_survival0.77030479
129MP0006072_abnormal_retinal_apoptosis0.76831411
130MP0004924_abnormal_behavior0.76485346
131MP0001270_distended_abdomen0.75739066
132MP0009780_abnormal_chondrocyte_physiolo0.75544959
133MP0002272_abnormal_nervous_system0.75374371
134MP0001730_embryonic_growth_arrest0.74239679
135MP0002127_abnormal_cardiovascular_syste0.73071650
136MP0001756_abnormal_urination0.71359222
137MP0006036_abnormal_mitochondrial_physio0.70297172
138MP0005451_abnormal_body_composition0.69358294
139MP0000428_abnormal_craniofacial_morphol0.68781590
140MP0000678_abnormal_parathyroid_gland0.67749040
141MP0001905_abnormal_dopamine_level0.67165713
142MP0005395_other_phenotype0.63067983
143MP0003937_abnormal_limbs/digits/tail_de0.62083923
144MP0003221_abnormal_cardiomyocyte_apopto0.61677935
145MP0002269_muscular_atrophy0.61605280
146MP0000538_abnormal_urinary_bladder0.61415041
147MP0003122_maternal_imprinting0.59259413
148MP0002069_abnormal_eating/drinking_beha0.58786064

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.44054450
2Myotonia (HP:0002486)4.01227623
3Ulnar bowing (HP:0003031)3.95188941
4Fragile nails (HP:0001808)3.89254904
5Rib fusion (HP:0000902)3.82467224
6Akinesia (HP:0002304)3.81301321
7Turricephaly (HP:0000262)3.79962677
8Multiple enchondromatosis (HP:0005701)3.54607454
9Down-sloping shoulders (HP:0200021)3.45750839
10Breast hypoplasia (HP:0003187)3.35772801
11Abnormality of secondary sexual hair (HP:0009888)3.33788444
12Abnormality of the axillary hair (HP:0100134)3.33788444
13Popliteal pterygium (HP:0009756)3.20411638
14Submucous cleft hard palate (HP:0000176)3.06767851
15Pterygium (HP:0001059)3.06654016
16Acute necrotizing encephalopathy (HP:0006965)3.00868803
17Short nail (HP:0001799)2.99871246
18Hypoplastic heart (HP:0001961)2.91346117
19Ventricular fibrillation (HP:0001663)2.89111813
20Conjugated hyperbilirubinemia (HP:0002908)2.86626664
21Bony spicule pigmentary retinopathy (HP:0007737)2.83991463
22Rough bone trabeculation (HP:0100670)2.80534414
23Progressive macrocephaly (HP:0004481)2.78850713
24Hypoplasia of the brainstem (HP:0002365)2.73558825
25Aplasia/Hypoplasia of the brainstem (HP:0007362)2.73558825
26Attenuation of retinal blood vessels (HP:0007843)2.72113773
27Cerebellar dysplasia (HP:0007033)2.71278821
28Cerebral hemorrhage (HP:0001342)2.69690610
29Congenital malformation of the right heart (HP:0011723)2.64988063
30Double outlet right ventricle (HP:0001719)2.64988063
31Septate vagina (HP:0001153)2.63035334
32Abnormality of the aortic arch (HP:0012303)2.61263820
33Renal Fanconi syndrome (HP:0001994)2.61134598
34Coronal craniosynostosis (HP:0004440)2.60010137
35Unilateral renal agenesis (HP:0000122)2.58676708
36Abnormality of placental membranes (HP:0011409)2.58335484
37Amniotic constriction ring (HP:0009775)2.58335484
38Exotropia (HP:0000577)2.55754710
39Poor suck (HP:0002033)2.53855955
40Ulnar claw (HP:0001178)2.53827665
41Termporal pattern (HP:0011008)2.52114012
42Insidious onset (HP:0003587)2.52114012
43Type II lissencephaly (HP:0007260)2.50329461
44Upper limb muscle weakness (HP:0003484)2.50298679
45Retinal dysplasia (HP:0007973)2.46569244
46Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.45179318
47Cerebral edema (HP:0002181)2.44921882
48Male infertility (HP:0003251)2.44156077
49Acute encephalopathy (HP:0006846)2.42256588
50Thin ribs (HP:0000883)2.39813503
51Congenital, generalized hypertrichosis (HP:0004540)2.37801244
52Abnormal respiratory epithelium morphology (HP:0012253)2.34504935
53Abnormal respiratory motile cilium morphology (HP:0005938)2.34504935
54Abnormality of cells of the erythroid lineage (HP:0012130)2.33078436
55Macrocytic anemia (HP:0001972)2.31833148
56Truncus arteriosus (HP:0001660)2.29324325
57Abnormal mitochondria in muscle tissue (HP:0008316)2.28557154
58Hypoplastic left heart (HP:0004383)2.24223113
59Fetal akinesia sequence (HP:0001989)2.24147877
60Mutism (HP:0002300)2.23625927
61Abnormality of pain sensation (HP:0010832)2.22811081
62Impaired pain sensation (HP:0007328)2.22811081
63Abnormal ventriculo-arterial connection (HP:0011563)2.22121558
64Transposition of the great arteries (HP:0001669)2.22121558
65Abnormal connection of the cardiac segments (HP:0011545)2.22121558
66Atrioventricular block (HP:0001678)2.19045696
67Abnormal trabecular bone morphology (HP:0100671)2.17825800
68Pheochromocytoma (HP:0002666)2.15805756
69Reticulocytopenia (HP:0001896)2.14744359
70Shawl scrotum (HP:0000049)2.14742775
71Cerebral hypomyelination (HP:0006808)2.14285153
72Bowed forearm bones (HP:0003956)2.12993440
73Bowing of the arm (HP:0006488)2.12993440
74Muscle stiffness (HP:0003552)2.10912685
75Amblyopia (HP:0000646)2.09526430
76Spinal cord compression (HP:0002176)2.09494287
77Hyperacusis (HP:0010780)2.08758624
78Atelectasis (HP:0100750)2.08463780
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06971279
80Hyperglycinuria (HP:0003108)2.06322347
81Severe visual impairment (HP:0001141)2.04518760
82Hyperglycinemia (HP:0002154)2.04332378
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03543820
84Muscle fiber splitting (HP:0003555)2.02349139
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02043144
86Mixed hearing impairment (HP:0000410)2.02036147
87Vaginal fistula (HP:0004320)2.00502454
88Testicular atrophy (HP:0000029)2.00402295
89Postural tremor (HP:0002174)2.00100730
90Foot dorsiflexor weakness (HP:0009027)1.98646799
91Lower limb asymmetry (HP:0100559)1.98372190
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.97892575
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97562659
94Annular pancreas (HP:0001734)1.96437592
95Diminished movement (HP:0002374)1.96153430
96Limb dystonia (HP:0002451)1.96085658
97Abnormal pupillary function (HP:0007686)1.95748774
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94166152
99Carpal bone hypoplasia (HP:0001498)1.92733523
100Aplasia/Hypoplasia of the patella (HP:0006498)1.92698076
101Mitochondrial inheritance (HP:0001427)1.92028352
102Broad distal phalanx of finger (HP:0009836)1.91465772
103Patellar aplasia (HP:0006443)1.91334171
104Hyperparathyroidism (HP:0000843)1.90765307
105Ankle clonus (HP:0011448)1.90171817
106Segmental peripheral demyelination/remyelination (HP:0003481)1.89965018
107Neuroblastic tumors (HP:0004376)1.89379781
108Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89379781
109Neuroblastoma (HP:0003006)1.89379781
110Primitive neuroectodermal tumor (HP:0030065)1.89379781
111Short palpebral fissure (HP:0012745)1.88822276
112Abnormality of the 4th metacarpal (HP:0010012)1.88377221
113Fused cervical vertebrae (HP:0002949)1.87317530
114Abnormal hemoglobin (HP:0011902)1.87134512
115Rectovaginal fistula (HP:0000143)1.86850020
116Rectal fistula (HP:0100590)1.86850020
117Aplasia of the musculature (HP:0100854)1.85512478
118Nasal speech (HP:0001611)1.85146358
119High anterior hairline (HP:0009890)1.84476978
120Lissencephaly (HP:0001339)1.83864589
121Increased hepatocellular lipid droplets (HP:0006565)1.83736869
122Neonatal onset (HP:0003623)1.83683375
123Congenital glaucoma (HP:0001087)1.82802912
124Restlessness (HP:0000711)1.82082195
125Abnormality of the distal phalanges of the toes (HP:0010182)1.81615173
126Pallor (HP:0000980)1.81357690
127Anterior segment dysgenesis (HP:0007700)1.80008601
128Short 1st metacarpal (HP:0010034)1.79910747
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79910747
130Buphthalmos (HP:0000557)1.78745798
131Abnormality of the foot musculature (HP:0001436)1.78328650
132Failure to thrive in infancy (HP:0001531)1.78064877
133Angiofibromas (HP:0010615)1.76859337
134Adenoma sebaceum (HP:0009720)1.76859337
135Meningocele (HP:0002435)1.76625561
136Renovascular hypertension (HP:0100817)1.76461233
137Delayed epiphyseal ossification (HP:0002663)1.76288706
138Asymmetric growth (HP:0100555)1.75478733
139Megalocornea (HP:0000485)1.75345309
140Hypomagnesemia (HP:0002917)1.75267870
141Neuroendocrine neoplasm (HP:0100634)1.75241264
142Intellectual disability, moderate (HP:0002342)1.74943073
143Hypercortisolism (HP:0001578)1.74751017
144Gout (HP:0001997)1.73948240
145Muscle fiber atrophy (HP:0100295)1.73856411
146Hypophosphatemic rickets (HP:0004912)1.73404164
147Chronic hepatic failure (HP:0100626)1.73359180
148Distal lower limb muscle weakness (HP:0009053)1.73309298
149Morphological abnormality of the middle ear (HP:0008609)1.72974306
150Action tremor (HP:0002345)1.72590057
151Hyperthyroidism (HP:0000836)1.72496156
152Obsessive-compulsive behavior (HP:0000722)1.72178928
153Abnormal cartilage morphology (HP:0002763)1.72160432
154Absent/shortened dynein arms (HP:0200106)1.71915743
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.71915743
156Polyphagia (HP:0002591)1.71878931
157Narrow nasal bridge (HP:0000446)1.71062538
158Agitation (HP:0000713)1.70923781
159Lipid accumulation in hepatocytes (HP:0006561)1.70505948
160Thin bony cortex (HP:0002753)1.70161272
161Spina bifida occulta (HP:0003298)1.69682417
162Morphological abnormality of the inner ear (HP:0011390)1.69674360
163Poikiloderma (HP:0001029)1.69614460
164Abnormalities of placenta or umbilical cord (HP:0001194)1.69433111
165Abnormality of magnesium homeostasis (HP:0004921)1.69390366
166Hypoventilation (HP:0002791)1.68688765
167Focal seizures (HP:0007359)1.68520082
168Optic nerve coloboma (HP:0000588)1.68375049
169Anteriorly placed anus (HP:0001545)1.67497960
170Preauricular pit (HP:0004467)1.65452861
171Periauricular skin pits (HP:0100277)1.65452861
172Abnormal number of erythroid precursors (HP:0012131)1.64631242
173Insomnia (HP:0100785)1.63141757
174Intestinal fistula (HP:0100819)1.62799213
175Facial hemangioma (HP:0000329)1.61907310
176Abnormal ciliary motility (HP:0012262)1.61699761
177Elfin facies (HP:0004428)1.61508131
178Enlarged epiphyses (HP:0010580)1.60494297
179Renal dysplasia (HP:0000110)1.58791887
180Torticollis (HP:0000473)1.58418615
181Polymicrogyria (HP:0002126)1.55131747
182Difficulty climbing stairs (HP:0003551)1.54887677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.47167375
2EPHB25.31106259
3MAPK134.29905035
4MARK13.34434672
5GRK53.33394659
6CASK3.32866942
7NME23.10016555
8NTRK33.08636807
9PNCK2.66980536
10NME12.51879174
11TNIK2.44425374
12PRKD32.38366780
13MAPK122.33791987
14WNK32.27682888
15VRK22.12237048
16BUB12.12172428
17TRIB31.90151034
18ICK1.85259428
19EPHA21.83233543
20TAF11.82187502
21LATS21.78867185
22TESK11.76516213
23ARAF1.72750253
24MUSK1.67757590
25TIE11.67356071
26PIM21.65874648
27MAP2K71.64825993
28FER1.60481166
29DAPK21.58859075
30AKT31.56942435
31DYRK21.53644656
32PLK41.52897674
33SIK21.48421883
34TSSK61.46622252
35SRPK11.44120916
36MST41.40518928
37MAP3K101.34950329
38MAPK111.33114603
39CDK141.26230638
40CSNK1A1L1.25481349
41SMG11.25100924
42WEE11.20982424
43MINK11.20014050
44DYRK1B1.17346257
45CSNK1G31.16271340
46UHMK11.16159908
47EPHB11.16098505
48BRSK11.15629552
49TYRO31.15429005
50MAPK41.13903775
51NTRK11.13622565
52MAP3K91.08452444
53LIMK11.03916343
54DDR21.01426125
55NLK1.01265161
56PAK30.97014660
57CSNK1G10.95608245
58PHKG20.93695643
59PHKG10.93695643
60NEK20.91744775
61CHEK20.90200653
62ALK0.88357852
63MAP3K20.85652377
64NTRK20.85105127
65PKN10.83886408
66DYRK30.83731958
67BCR0.83397343
68VRK10.79677830
69STK160.79197423
70MAP3K110.78286165
71CSNK1G20.77372903
72MAP2K40.77031425
73CAMK1G0.75184437
74RPS6KB20.73880744
75SIK10.73284511
76MAP2K20.72292120
77CDK80.71544645
78SGK2230.71118407
79SGK4940.71118407
80MTOR0.70564631
81KSR20.70564380
82LMTK20.70389949
83ADRBK10.68880994
84CSNK1E0.68502681
85ABL20.68332092
86STK390.68284152
87PAK60.68231756
88PRKCI0.66163441
89PRKCG0.66046958
90KSR10.63345927
91PAK20.61689668
92MARK20.60304601
93PAK10.59782956
94MST1R0.58753114
95CDK70.58485937
96ERBB20.58098884
97EEF2K0.57498868
98PDPK10.57236574
99AKT20.56763074
100CDK120.55784444
101IRAK30.55727379
102ILK0.55635976
103CDK11A0.55397483
104MAP3K40.55225758
105FES0.55219250
106RPS6KA20.53307668
107BRD40.53140742
108WNK40.52897817
109CAMK2G0.52675049
110STK380.51843370
111STK240.51805241
112CDK150.50362084
113RET0.49858111
114INSRR0.49507078
115AURKA0.49434687
116MATK0.48900954
117PRKACG0.47250931
118MAP2K10.47146390
119CDK180.46725694
120PDK20.45761742
121CAMK2A0.45423735
122CDK10.44729630
123CAMK1D0.44538958
124CAMK2B0.44413104
125PRKACA0.43889402
126CSNK2A20.43511849
127WNK10.43289862
128CDK20.41860239
129TTK0.41766540
130TLK10.41696902
131DAPK30.41447345
132CDC42BPA0.41002921
133ROCK10.40981589
134TESK20.40247477
135IRAK20.40065168
136CAMK10.39753154
137NEK10.39428692
138MAPK80.39339918
139NUAK10.38733560
140BRAF0.36931633
141PBK0.36805182
142CDK50.35855863
143MET0.35646292
144CSNK2A10.35187732
145MKNK10.34767113
146MAPKAPK50.34138523
147GSK3B0.33691426
148PKN20.33385913
149BCKDK0.31723048
150MAPK140.31622123
151CCNB10.30152198
152DYRK1A0.29913264
153MAPK90.29479007

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10673765
2Proteasome_Homo sapiens_hsa030504.75663014
3Oxidative phosphorylation_Homo sapiens_hsa001903.74811020
4Parkinsons disease_Homo sapiens_hsa050123.71704201
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.30501939
6Huntingtons disease_Homo sapiens_hsa050162.69962965
7Cardiac muscle contraction_Homo sapiens_hsa042602.69175088
8Alzheimers disease_Homo sapiens_hsa050102.46814615
9RNA polymerase_Homo sapiens_hsa030202.41233093
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28483799
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.26550703
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06217397
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04339423
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86381718
15Hedgehog signaling pathway_Homo sapiens_hsa043401.79052769
16Cocaine addiction_Homo sapiens_hsa050301.64471250
17Caffeine metabolism_Homo sapiens_hsa002321.61873838
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57417723
19Regulation of autophagy_Homo sapiens_hsa041401.53841863
20Alcoholism_Homo sapiens_hsa050341.52785450
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43888032
22Notch signaling pathway_Homo sapiens_hsa043301.40049852
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.39879332
24Phototransduction_Homo sapiens_hsa047441.38672320
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37800614
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35707751
27Fanconi anemia pathway_Homo sapiens_hsa034601.33355787
28Synaptic vesicle cycle_Homo sapiens_hsa047211.30005655
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28879453
30Vitamin B6 metabolism_Homo sapiens_hsa007501.27201236
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24430375
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22597928
33Spliceosome_Homo sapiens_hsa030401.20670776
34Butanoate metabolism_Homo sapiens_hsa006501.18403028
35Morphine addiction_Homo sapiens_hsa050321.14400748
36Fatty acid biosynthesis_Homo sapiens_hsa000611.14163429
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13281589
38Pyrimidine metabolism_Homo sapiens_hsa002401.12620651
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11156430
40Colorectal cancer_Homo sapiens_hsa052101.08807274
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.08114803
42Arginine biosynthesis_Homo sapiens_hsa002201.08038243
43Circadian entrainment_Homo sapiens_hsa047131.05064533
44RNA transport_Homo sapiens_hsa030131.01716811
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00489397
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98045420
47Collecting duct acid secretion_Homo sapiens_hsa049660.95580075
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94659455
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93372253
50Selenocompound metabolism_Homo sapiens_hsa004500.93341594
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92425155
52Axon guidance_Homo sapiens_hsa043600.92162665
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89909380
54Sulfur relay system_Homo sapiens_hsa041220.87949614
55Insulin signaling pathway_Homo sapiens_hsa049100.87144167
56Prion diseases_Homo sapiens_hsa050200.84710630
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84253562
58Vibrio cholerae infection_Homo sapiens_hsa051100.82707248
59Cell cycle_Homo sapiens_hsa041100.82071539
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79971331
61Fatty acid elongation_Homo sapiens_hsa000620.76423387
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76182728
63Fructose and mannose metabolism_Homo sapiens_hsa000510.74469364
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74322371
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.71460669
66mRNA surveillance pathway_Homo sapiens_hsa030150.70147538
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69796360
68Taste transduction_Homo sapiens_hsa047420.69614624
69Sphingolipid metabolism_Homo sapiens_hsa006000.69202747
70MAPK signaling pathway_Homo sapiens_hsa040100.68716137
71Pentose phosphate pathway_Homo sapiens_hsa000300.68387282
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.67985997
73Dilated cardiomyopathy_Homo sapiens_hsa054140.67796666
74Thyroid cancer_Homo sapiens_hsa052160.66199115
75Fat digestion and absorption_Homo sapiens_hsa049750.65825414
76AMPK signaling pathway_Homo sapiens_hsa041520.65488482
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.65481755
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65186655
79Base excision repair_Homo sapiens_hsa034100.63891356
80Arginine and proline metabolism_Homo sapiens_hsa003300.63494054
81Bile secretion_Homo sapiens_hsa049760.62961503
82Endometrial cancer_Homo sapiens_hsa052130.62505364
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62492302
84Type II diabetes mellitus_Homo sapiens_hsa049300.61851609
85Steroid biosynthesis_Homo sapiens_hsa001000.61269817
86Bladder cancer_Homo sapiens_hsa052190.60289360
87Complement and coagulation cascades_Homo sapiens_hsa046100.59839455
88Wnt signaling pathway_Homo sapiens_hsa043100.58263574
89Amphetamine addiction_Homo sapiens_hsa050310.57824186
90Basal transcription factors_Homo sapiens_hsa030220.56490776
91Hippo signaling pathway_Homo sapiens_hsa043900.56029259
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55924262
93Oocyte meiosis_Homo sapiens_hsa041140.54005155
94VEGF signaling pathway_Homo sapiens_hsa043700.53982484
95Chronic myeloid leukemia_Homo sapiens_hsa052200.53365667
96Carbon metabolism_Homo sapiens_hsa012000.53098128
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51760071
98Metabolic pathways_Homo sapiens_hsa011000.50836525
99Phenylalanine metabolism_Homo sapiens_hsa003600.50782670
100Melanogenesis_Homo sapiens_hsa049160.50446578
101Retinol metabolism_Homo sapiens_hsa008300.50318161
102Dorso-ventral axis formation_Homo sapiens_hsa043200.50181806
103Glycerolipid metabolism_Homo sapiens_hsa005610.49943378
104Glioma_Homo sapiens_hsa052140.49885832
105N-Glycan biosynthesis_Homo sapiens_hsa005100.49314138
106Biosynthesis of amino acids_Homo sapiens_hsa012300.49312330
107ErbB signaling pathway_Homo sapiens_hsa040120.49076464
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47440910
109Dopaminergic synapse_Homo sapiens_hsa047280.47328305
110mTOR signaling pathway_Homo sapiens_hsa041500.46609822
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46426989
112GABAergic synapse_Homo sapiens_hsa047270.45996328
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45810210
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45484761
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45324375
116Gap junction_Homo sapiens_hsa045400.44669231
117cAMP signaling pathway_Homo sapiens_hsa040240.44476308
118Non-small cell lung cancer_Homo sapiens_hsa052230.44381254
119Endocytosis_Homo sapiens_hsa041440.43891278
120Olfactory transduction_Homo sapiens_hsa047400.43290068
121Cholinergic synapse_Homo sapiens_hsa047250.43188103
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43113108
123Calcium signaling pathway_Homo sapiens_hsa040200.42761753
124TGF-beta signaling pathway_Homo sapiens_hsa043500.42734222
125Lysine degradation_Homo sapiens_hsa003100.42449159
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41172117
127Folate biosynthesis_Homo sapiens_hsa007900.40993967
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.39312201
129Insulin secretion_Homo sapiens_hsa049110.37532468
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37211912
131Glutamatergic synapse_Homo sapiens_hsa047240.36709850
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35600351
133Fatty acid metabolism_Homo sapiens_hsa012120.34904972
134Tryptophan metabolism_Homo sapiens_hsa003800.33936198
135Nitrogen metabolism_Homo sapiens_hsa009100.33698506
136Glutathione metabolism_Homo sapiens_hsa004800.29548619
137Estrogen signaling pathway_Homo sapiens_hsa049150.29544330
138Mineral absorption_Homo sapiens_hsa049780.29191514
139p53 signaling pathway_Homo sapiens_hsa041150.28996813
140Basal cell carcinoma_Homo sapiens_hsa052170.28885820
141Tight junction_Homo sapiens_hsa045300.27791157
142Circadian rhythm_Homo sapiens_hsa047100.26403224
143Vitamin digestion and absorption_Homo sapiens_hsa049770.26215122
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26068373
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.25833620
146beta-Alanine metabolism_Homo sapiens_hsa004100.25752101
147Nicotine addiction_Homo sapiens_hsa050330.25564867
148Nucleotide excision repair_Homo sapiens_hsa034200.25059436

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