C1QTNF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)9.26506985
2extracellular fibril organization (GO:0043206)7.13753450
3dermatan sulfate biosynthetic process (GO:0030208)6.82452455
4bone trabecula formation (GO:0060346)6.50027850
5dermatan sulfate metabolic process (GO:0030205)6.37257899
6* protein heterotrimerization (GO:0070208)6.34365705
7fibril organization (GO:0097435)6.21957215
8collagen fibril organization (GO:0030199)6.00522802
9behavioral response to nicotine (GO:0035095)5.43887441
10keratan sulfate catabolic process (GO:0042340)5.39712048
11blood vessel maturation (GO:0001955)5.16383578
12sequestering of extracellular ligand from receptor (GO:0035581)4.84886153
13chondroitin sulfate catabolic process (GO:0030207)4.67286462
14collagen metabolic process (GO:0032963)4.61472703
15collagen catabolic process (GO:0030574)4.53814957
16water-soluble vitamin biosynthetic process (GO:0042364)4.45282623
17DNA deamination (GO:0045006)4.36764563
18multicellular organismal macromolecule metabolic process (GO:0044259)4.36296630
19protein retention in ER lumen (GO:0006621)4.29041472
20multicellular organismal catabolic process (GO:0044243)4.21731545
21multicellular organismal metabolic process (GO:0044236)4.13371925
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.95318623
23lymph vessel development (GO:0001945)3.89999367
24trabecula formation (GO:0060343)3.85626536
25extracellular matrix disassembly (GO:0022617)3.78569456
26glomerular basement membrane development (GO:0032836)3.77646064
27endothelial cell morphogenesis (GO:0001886)3.73796377
28piRNA metabolic process (GO:0034587)3.69360732
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.67329145
30endodermal cell differentiation (GO:0035987)3.64639957
31chondroitin sulfate biosynthetic process (GO:0030206)3.64395606
32positive regulation of osteoblast proliferation (GO:0033690)3.63322297
33cell migration involved in heart development (GO:0060973)3.57575411
34cell proliferation involved in kidney development (GO:0072111)3.56472608
35extracellular matrix assembly (GO:0085029)3.55939360
36fucose catabolic process (GO:0019317)3.51657125
37L-fucose metabolic process (GO:0042354)3.51657125
38L-fucose catabolic process (GO:0042355)3.51657125
39axoneme assembly (GO:0035082)3.50531544
40response to pheromone (GO:0019236)3.49358633
41basement membrane organization (GO:0071711)3.41781258
42platelet dense granule organization (GO:0060155)3.40812467
43extracellular matrix organization (GO:0030198)3.39580416
44extracellular structure organization (GO:0043062)3.38330282
45ubiquinone biosynthetic process (GO:0006744)3.35687082
46adaptation of signaling pathway (GO:0023058)3.35648654
47chondrocyte proliferation (GO:0035988)3.35262434
48cranial suture morphogenesis (GO:0060363)3.33940010
49negative regulation of complement activation (GO:0045916)3.33631704
50craniofacial suture morphogenesis (GO:0097094)3.32820156
51endothelial cell proliferation (GO:0001935)3.31239390
52venous blood vessel morphogenesis (GO:0048845)3.30374371
53endocardial cushion morphogenesis (GO:0003203)3.29536288
54retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29163798
55detection of light stimulus involved in sensory perception (GO:0050962)3.29095101
56detection of light stimulus involved in visual perception (GO:0050908)3.29095101
57negative regulation of fatty acid transport (GO:2000192)3.28435732
58protein polyglutamylation (GO:0018095)3.27927128
59peripheral nervous system axon ensheathment (GO:0032292)3.27910941
60myelination in peripheral nervous system (GO:0022011)3.27910941
61sulfur compound catabolic process (GO:0044273)3.23887578
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23734645
63skin morphogenesis (GO:0043589)3.22467188
64atrioventricular valve morphogenesis (GO:0003181)3.20774116
65tachykinin receptor signaling pathway (GO:0007217)3.20443249
66glomerulus development (GO:0032835)3.18333615
67regulation of hexokinase activity (GO:1903299)3.17889732
68regulation of glucokinase activity (GO:0033131)3.17889732
69outer ear morphogenesis (GO:0042473)3.15855508
70DNA methylation involved in gamete generation (GO:0043046)3.12078406
71extracellular regulation of signal transduction (GO:1900115)3.11957655
72extracellular negative regulation of signal transduction (GO:1900116)3.11957655
73mesenchyme morphogenesis (GO:0072132)3.09830160
74ubiquinone metabolic process (GO:0006743)3.05115950
75auditory receptor cell differentiation (GO:0042491)3.03945303
76indolalkylamine metabolic process (GO:0006586)3.02330350
77peptide cross-linking (GO:0018149)3.02305279
78retinal cone cell development (GO:0046549)3.00808735
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99487665
80axon extension involved in axon guidance (GO:0048846)2.98892349
81neuron projection extension involved in neuron projection guidance (GO:1902284)2.98892349
82metanephric mesenchyme development (GO:0072075)2.98806808
83glycosaminoglycan catabolic process (GO:0006027)2.93949817
84nonmotile primary cilium assembly (GO:0035058)2.93560621
85behavioral response to ethanol (GO:0048149)2.93502381
86regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.91845233
87synaptic transmission, cholinergic (GO:0007271)2.91155348
88vitamin A metabolic process (GO:0006776)2.90979344
89regulation of cilium movement (GO:0003352)2.90796019
90vascular endothelial growth factor signaling pathway (GO:0038084)2.90305224
91negative regulation of protein activation cascade (GO:2000258)2.85046006
92negative regulation of telomere maintenance (GO:0032205)2.84928615
93cornea development in camera-type eye (GO:0061303)2.84180468
94regulation of action potential (GO:0098900)2.81960826
95respiratory chain complex IV assembly (GO:0008535)2.81043221
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80605891
97protein complex biogenesis (GO:0070271)2.80474098
98preassembly of GPI anchor in ER membrane (GO:0016254)2.80262079
99positive regulation of endothelial cell differentiation (GO:0045603)2.79701616
100head development (GO:0060322)2.79614080
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78519662
102smooth muscle tissue development (GO:0048745)2.78201109
103camera-type eye morphogenesis (GO:0048593)2.77785484
104cellular ketone body metabolic process (GO:0046950)2.77094231
105arginine catabolic process (GO:0006527)2.76988863
106regulation of endothelial cell differentiation (GO:0045601)2.74838011
107virion attachment to host cell (GO:0019062)2.74694720
108adhesion of symbiont to host cell (GO:0044650)2.74694720
109L-methionine salvage (GO:0071267)2.74670974
110L-methionine biosynthetic process (GO:0071265)2.74670974
111amino acid salvage (GO:0043102)2.74670974
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74043518
113cilium morphogenesis (GO:0060271)2.73318950
114protein targeting to plasma membrane (GO:0072661)2.73258894
115glomerular filtration (GO:0003094)2.72514025
116aminoglycan catabolic process (GO:0006026)2.71577043
117kidney mesenchyme development (GO:0072074)2.70600955
118regulation of SMAD protein import into nucleus (GO:0060390)2.69948725
119positive regulation of glomerulus development (GO:0090193)2.69692393
120negative regulation of chondrocyte differentiation (GO:0032331)2.69489907
121cytidine deamination (GO:0009972)2.69193727
122cytidine metabolic process (GO:0046087)2.69193727
123cytidine catabolic process (GO:0006216)2.69193727
124cell proliferation involved in metanephros development (GO:0072203)2.66595045
125kynurenine metabolic process (GO:0070189)2.66495519
126wound healing, spreading of epidermal cells (GO:0035313)2.65460270
127regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64765071
128plasma membrane repair (GO:0001778)2.64643187
129barbed-end actin filament capping (GO:0051016)2.64567108
130face morphogenesis (GO:0060325)2.64115477
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63854254
132protein localization to cilium (GO:0061512)2.62596312
133nucleotide-sugar biosynthetic process (GO:0009226)2.61984166
134cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61968620
135negative regulation of systemic arterial blood pressure (GO:0003085)2.61965154
136glycosphingolipid biosynthetic process (GO:0006688)2.61904842
137negative regulation of cardiac muscle tissue growth (GO:0055022)2.61372482
138negative regulation of heart growth (GO:0061117)2.61372482
139inositol phosphate catabolic process (GO:0071545)2.61358036
140type B pancreatic cell proliferation (GO:0044342)2.60832373
141negative regulation of nitric-oxide synthase activity (GO:0051001)2.59941348
142positive regulation of epithelial to mesenchymal transition (GO:0010718)2.59351511
143primary amino compound metabolic process (GO:1901160)2.58816384
144negative regulation of mast cell activation (GO:0033004)2.58514085
145regulation of striated muscle cell apoptotic process (GO:0010662)2.58022725
146quinone biosynthetic process (GO:1901663)2.57949378
147mitochondrial respiratory chain complex I assembly (GO:0032981)2.56301586
148NADH dehydrogenase complex assembly (GO:0010257)2.56301586
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56301586
150stress fiber assembly (GO:0043149)2.56254265
151regulation of macrophage cytokine production (GO:0010935)2.55837230
152positive regulation of metanephros development (GO:0072216)2.55252900
153adhesion of symbiont to host (GO:0044406)2.54528034
154heart trabecula formation (GO:0060347)2.54521224
155regulation of neurotransmitter uptake (GO:0051580)2.54061366
156* protein trimerization (GO:0070206)2.53980676
157ketone body metabolic process (GO:1902224)2.53458311
158negative regulation of catenin import into nucleus (GO:0035414)2.53177373
159negative regulation of cartilage development (GO:0061037)2.53168694
160negative regulation of BMP signaling pathway (GO:0030514)2.52433011
161photoreceptor cell development (GO:0042461)2.52113641
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.51976751
163sulfation (GO:0051923)2.51766861
164mitochondrial respiratory chain complex assembly (GO:0033108)2.51629124
165regulation of glomerulus development (GO:0090192)2.51114492
166cellular response to amino acid stimulus (GO:0071230)2.50956179
167regulation of metanephros development (GO:0072215)2.50376219
168postsynaptic membrane organization (GO:0001941)2.50306453
169indole-containing compound catabolic process (GO:0042436)2.50290389
170indolalkylamine catabolic process (GO:0046218)2.50290389
171tryptophan catabolic process (GO:0006569)2.50290389
172mannosylation (GO:0097502)2.49177912
173photoreceptor cell maintenance (GO:0045494)2.48503438
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47745854
175protein K6-linked ubiquitination (GO:0085020)2.47426032
176glycerophospholipid catabolic process (GO:0046475)2.45764724
177arginine metabolic process (GO:0006525)2.45746713
178rhodopsin mediated signaling pathway (GO:0016056)2.45656548
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.43465528
180regulation of meiosis I (GO:0060631)2.42365081
181adenosine metabolic process (GO:0046085)2.41506407
182GPI anchor metabolic process (GO:0006505)2.40239373
183S-adenosylmethionine metabolic process (GO:0046500)2.39588731
184startle response (GO:0001964)2.38192335
185pyrimidine nucleobase catabolic process (GO:0006208)2.37578689
186cytochrome complex assembly (GO:0017004)2.37412028
187indole-containing compound metabolic process (GO:0042430)2.35195399
188inner ear receptor stereocilium organization (GO:0060122)2.34890264
189C4-dicarboxylate transport (GO:0015740)2.34139640
190metallo-sulfur cluster assembly (GO:0031163)2.33954753
191iron-sulfur cluster assembly (GO:0016226)2.33954753
192amine catabolic process (GO:0009310)2.33935287
193cellular biogenic amine catabolic process (GO:0042402)2.33935287
194phosphatidylinositol acyl-chain remodeling (GO:0036149)2.33141086
195G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.33110099
196membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32861144
197visual perception (GO:0007601)2.31382024
198cardiac right ventricle morphogenesis (GO:0003215)2.31293135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.54139419
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.86214764
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.18799280
4ZNF274_21170338_ChIP-Seq_K562_Hela3.96022204
5EZH2_22144423_ChIP-Seq_EOC_Human3.38260563
6VDR_22108803_ChIP-Seq_LS180_Human3.20232087
7CLOCK_20551151_ChIP-Seq_293T_Human3.06878237
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.88876157
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.87082614
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.83751515
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62584118
12GBX2_23144817_ChIP-Seq_PC3_Human2.61113630
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.50485838
14CJUN_26792858_Chip-Seq_BT549_Human2.45621356
15CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.32323800
16AR_21572438_ChIP-Seq_LNCaP_Human2.26726029
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.26704254
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22668207
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.21267922
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.20405388
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.18066783
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16774025
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11405420
24IGF1R_20145208_ChIP-Seq_DFB_Human2.11328913
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04696161
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.04447625
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96521059
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96051846
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91758992
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.89366347
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88577173
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88577173
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87302369
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86609984
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85950855
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84046075
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83643225
38P300_19829295_ChIP-Seq_ESCs_Human1.82151352
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.78648926
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74634638
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74355427
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72178002
43FUS_26573619_Chip-Seq_HEK293_Human1.69594675
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66901587
45EWS_26573619_Chip-Seq_HEK293_Human1.66040054
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65315602
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.64678420
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64414475
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.64343736
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.64058995
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59324105
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59029687
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58038115
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57070334
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54282439
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54282439
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53920506
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.52693214
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52445702
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49942498
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48767012
62BRD4_25478319_ChIP-Seq_HGPS_Human1.46206869
63ER_23166858_ChIP-Seq_MCF-7_Human1.45500610
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44997342
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43762632
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.43026386
67TP53_22573176_ChIP-Seq_HFKS_Human1.42092306
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41938360
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.41523960
70SMAD4_21799915_ChIP-Seq_A2780_Human1.40494247
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40128060
72CBP_20019798_ChIP-Seq_JUKART_Human1.40128060
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38980273
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.38841907
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38147136
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37746311
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.37735353
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37070528
79IRF1_19129219_ChIP-ChIP_H3396_Human1.36739764
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36293886
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35827116
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35525970
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35495082
84TP53_18474530_ChIP-ChIP_U2OS_Human1.35223751
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34124508
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33422139
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32977325
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32693158
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.32213020
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32171786
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.32151996
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31972828
93TCF4_22108803_ChIP-Seq_LS180_Human1.29664755
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.29206070
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27952492
96* NANOG_19829295_ChIP-Seq_ESCs_Human1.27180682
97* SOX2_19829295_ChIP-Seq_ESCs_Human1.27180682
98STAT3_23295773_ChIP-Seq_U87_Human1.27111007
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26913153
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26590347
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.26210433
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25824855
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25068106
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.24087313
105TCF4_23295773_ChIP-Seq_U87_Human1.24084457
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23607269
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.23370843
108SOX2_20726797_ChIP-Seq_SW620_Human1.23287477
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.22264530
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.22045974
111AR_25329375_ChIP-Seq_VCAP_Human1.21410063
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20219575
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20166511
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20069934
115TAF15_26573619_Chip-Seq_HEK293_Human1.19217552
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19073682
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.18896514
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.18832018
119REST_21632747_ChIP-Seq_MESCs_Mouse1.18288703
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17203876
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17116777
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17030982
123NCOR_22424771_ChIP-Seq_293T_Human1.17023629
124RNF2_27304074_Chip-Seq_NSC_Mouse1.16543192
125EST1_17652178_ChIP-ChIP_JURKAT_Human1.15807281
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15307195
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15307195
128TBX20_22080862_ChIP-Seq_HEART_Mouse1.14521135
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.14521135
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.14492029
131AR_20517297_ChIP-Seq_VCAP_Human1.14480886
132SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14459513
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14378228
134SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13114000
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12093128
136RUNX2_22187159_ChIP-Seq_PCA_Human1.11986906
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11026474
138FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10434666
139FOXA1_25329375_ChIP-Seq_VCAP_Human1.10434666
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10195421
141DROSHA_22980978_ChIP-Seq_HELA_Human1.10182301
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09666979
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09066635
144HOXB7_26014856_ChIP-Seq_BT474_Human1.09010650
145MYC_18940864_ChIP-ChIP_HL60_Human1.08660650
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08438547
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07448609
148RNF2_27304074_Chip-Seq_ESCs_Mouse1.06246580
149* CRX_20693478_ChIP-Seq_RETINA_Mouse1.06068610
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05774301
151SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05300632
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05036771
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04185101
154RING1B_27294783_Chip-Seq_ESCs_Mouse1.04059352
155SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03533414
156CDX2_22108803_ChIP-Seq_LS180_Human1.02187781
157FOXH1_21741376_ChIP-Seq_EPCs_Human1.02154546
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01491779
159SA1_22415368_ChIP-Seq_MEFs_Mouse1.00884235
160MYC_19829295_ChIP-Seq_ESCs_Human1.00008678
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99525952
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99064231
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.99061053
164LXR_22158963_ChIP-Seq_LIVER_Mouse0.98523450
165TAF2_19829295_ChIP-Seq_ESCs_Human0.97976815
166PRDM14_20953172_ChIP-Seq_ESCs_Human0.97839455
167SRF_21415370_ChIP-Seq_HL-1_Mouse0.97769474
168TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97160927
169BCAT_22108803_ChIP-Seq_LS180_Human0.95893774
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95805040
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94612695
172JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93823138
173NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93555443
174UBF1/2_26484160_Chip-Seq_HMECs_Human0.93365440
175KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92315518
176ERG_21242973_ChIP-ChIP_JURKAT_Human0.91111713
177TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90438816
178ISL1_27105846_Chip-Seq_CPCs_Mouse0.84874006
179WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84510003
180LXR_22292898_ChIP-Seq_THP-1_Human0.84019305
181PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83591444
182TP53_16413492_ChIP-PET_HCT116_Human0.83428177
183KDM2B_26808549_Chip-Seq_K562_Human0.83139310
184SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81768129
185SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81768129
186ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80773721
187STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80543396
188PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80119835
189* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80050607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.16214730
2MP0005503_abnormal_tendon_morphology8.15301033
3MP0005275_abnormal_skin_tensile6.50647431
4MP0001958_emphysema3.78471166
5MP0003279_aneurysm3.35167569
6MP0002102_abnormal_ear_morphology3.32915750
7MP0003705_abnormal_hypodermis_morpholog3.08604473
8MP0004272_abnormal_basement_membrane2.98110486
9MP0010368_abnormal_lymphatic_system2.94079960
10MP0008877_abnormal_DNA_methylation2.82437526
11MP0006054_spinal_hemorrhage2.58564373
12MP0005508_abnormal_skeleton_morphology2.46618145
13MP0005551_abnormal_eye_electrophysiolog2.39072373
14MP0002108_abnormal_muscle_morphology2.37366881
15MP0003283_abnormal_digestive_organ2.25192905
16MP0002876_abnormal_thyroid_physiology2.21763048
17MP0002060_abnormal_skin_morphology2.14943852
18MP0006292_abnormal_olfactory_placode2.10427677
19MP0003787_abnormal_imprinting2.02961877
20MP0002653_abnormal_ependyma_morphology1.97202256
21MP0000751_myopathy1.96875201
22MP0006072_abnormal_retinal_apoptosis1.96172510
23MP0004133_heterotaxia1.95565281
24MP0003136_yellow_coat_color1.92256035
25MP0001879_abnormal_lymphatic_vessel1.89527101
26MP0002295_abnormal_pulmonary_circulatio1.88375641
27MP0001243_abnormal_dermal_layer1.79403463
28MP0001542_abnormal_bone_strength1.76844494
29MP0002163_abnormal_gland_morphology1.72226051
30MP0002837_dystrophic_cardiac_calcinosis1.68247157
31MP0000427_abnormal_hair_cycle1.68024837
32MP0000372_irregular_coat_pigmentation1.66591516
33MP0004043_abnormal_pH_regulation1.64872899
34MP0001968_abnormal_touch/_nociception1.63512591
35MP0009384_cardiac_valve_regurgitation1.59772429
36MP0004885_abnormal_endolymph1.56594593
37MP0005253_abnormal_eye_physiology1.52224965
38MP0005023_abnormal_wound_healing1.51610511
39MP0006276_abnormal_autonomic_nervous1.51252237
40MP0005646_abnormal_pituitary_gland1.51228854
41MP0002938_white_spotting1.49087884
42MP0005257_abnormal_intraocular_pressure1.48268642
43MP0004142_abnormal_muscle_tone1.46161228
44MP0002736_abnormal_nociception_after1.41178866
45MP0003950_abnormal_plasma_membrane1.37489676
46MP0009250_abnormal_appendicular_skeleto1.37283480
47MP0001501_abnormal_sleep_pattern1.35222745
48MP0003195_calcinosis1.35107936
49MP0008872_abnormal_physiological_respon1.34464495
50MP0001986_abnormal_taste_sensitivity1.32974651
51MP0005390_skeleton_phenotype1.32930072
52MP0009046_muscle_twitch1.32841784
53MP0002160_abnormal_reproductive_system1.31746801
54MP0002638_abnormal_pupillary_reflex1.31402547
55MP0005623_abnormal_meninges_morphology1.31126025
56MP0000767_abnormal_smooth_muscle1.31070140
57MP0002234_abnormal_pharynx_morphology1.29109761
58MP0003880_abnormal_central_pattern1.27449623
59MP0005595_abnormal_vascular_smooth1.24862418
60MP0005379_endocrine/exocrine_gland_phen1.23883187
61MP0001984_abnormal_olfaction1.23593980
62MP0002272_abnormal_nervous_system1.23234522
63MP0009745_abnormal_behavioral_response1.22728348
64MP0003566_abnormal_cell_adhesion1.21168391
65MP0000631_abnormal_neuroendocrine_gland1.18793434
66MP0004484_altered_response_of1.17756058
67MP0005423_abnormal_somatic_nervous1.17485059
68MP0002282_abnormal_trachea_morphology1.16865736
69MP0008789_abnormal_olfactory_epithelium1.16372666
70MP0002735_abnormal_chemical_nociception1.16177382
71MP0008875_abnormal_xenobiotic_pharmacok1.16120678
72MP0003115_abnormal_respiratory_system1.15533159
73MP0003385_abnormal_body_wall1.15107204
74MP0003121_genomic_imprinting1.13572739
75MP0000343_altered_response_to1.11158257
76MP0002249_abnormal_larynx_morphology1.11000808
77MP0000749_muscle_degeneration1.10773028
78MP0004883_abnormal_blood_vessel1.10066454
79MP0001970_abnormal_pain_threshold1.09767594
80MP0000569_abnormal_digit_pigmentation1.09546006
81MP0005389_reproductive_system_phenotype1.09507418
82MP0002933_joint_inflammation1.09099151
83MP0003137_abnormal_impulse_conducting1.08519360
84MP0002572_abnormal_emotion/affect_behav1.08336878
85MP0000026_abnormal_inner_ear1.05067918
86MP0000733_abnormal_muscle_development1.04520133
87MP0000534_abnormal_ureter_morphology1.02992534
88MP0004084_abnormal_cardiac_muscle1.02678925
89MP0003942_abnormal_urinary_system1.02264650
90MP0002896_abnormal_bone_mineralization1.01623816
91MP0004134_abnormal_chest_morphology1.01405575
92MP0002734_abnormal_mechanical_nocicepti1.00920374
93MP0002733_abnormal_thermal_nociception1.00387770
94MP0003806_abnormal_nucleotide_metabolis0.99599465
95MP0010030_abnormal_orbit_morphology0.99035977
96MP0000163_abnormal_cartilage_morphology0.97646089
97MP0006138_congestive_heart_failure0.96436641
98MP0000013_abnormal_adipose_tissue0.96295401
99MP0005195_abnormal_posterior_eye0.96160610
100MP0005369_muscle_phenotype0.95100522
101MP0005645_abnormal_hypothalamus_physiol0.94972413
102MP0005164_abnormal_response_to0.94836159
103MP0002115_abnormal_skeleton_extremities0.92831617
104MP0002909_abnormal_adrenal_gland0.92608112
105MP0001485_abnormal_pinna_reflex0.91201574
106MP0000003_abnormal_adipose_tissue0.90675996
107MP0005330_cardiomyopathy0.90401777
108MP0002557_abnormal_social/conspecific_i0.89609581
109MP0003122_maternal_imprinting0.88724003
110MP0005165_increased_susceptibility_to0.88419257
111MP0004742_abnormal_vestibular_system0.88405182
112MP0002998_abnormal_bone_remodeling0.88391328
113MP0010386_abnormal_urinary_bladder0.88107607
114MP0005388_respiratory_system_phenotype0.87220754
115MP0002133_abnormal_respiratory_system0.87220754
116MP0002751_abnormal_autonomic_nervous0.87015112
117MP0002128_abnormal_blood_circulation0.86181043
118MP0001486_abnormal_startle_reflex0.85789552
119MP0000750_abnormal_muscle_regeneration0.85243865
120MP0001963_abnormal_hearing_physiology0.83934702
121MP0002932_abnormal_joint_morphology0.83645780
122MP0002752_abnormal_somatic_nervous0.82869456
123MP0005620_abnormal_muscle_contractility0.82841678
124MP0003938_abnormal_ear_development0.82406237
125MP0000778_abnormal_nervous_system0.80826430
126MP0008775_abnormal_heart_ventricle0.79763778
127MP0003646_muscle_fatigue0.79601639
128MP0004087_abnormal_muscle_fiber0.79319439
129MP0002233_abnormal_nose_morphology0.78906805
130MP0001175_abnormal_lung_morphology0.77761067
131MP0005385_cardiovascular_system_phenoty0.77314729
132MP0001544_abnormal_cardiovascular_syste0.77314729
133MP0000759_abnormal_skeletal_muscle0.77001766
134MP0002113_abnormal_skeleton_development0.76638323
135MP0001299_abnormal_eye_distance/0.76459916
136MP0000613_abnormal_salivary_gland0.76092220
137MP0004233_abnormal_muscle_weight0.75547076
138MP0005171_absent_coat_pigmentation0.75025903
139MP0002254_reproductive_system_inflammat0.74656672
140MP0002064_seizures0.74290382
141MP0003252_abnormal_bile_duct0.74053046
142MP0002063_abnormal_learning/memory/cond0.73919512
143MP0001905_abnormal_dopamine_level0.73738724
144MP0002972_abnormal_cardiac_muscle0.73181777
145MP0003795_abnormal_bone_structure0.72903667
146MP0003635_abnormal_synaptic_transmissio0.72891885
147MP0002067_abnormal_sensory_capabilities0.72163187
148MP0002090_abnormal_vision0.71552427
149MP0001533_abnormal_skeleton_physiology0.70401686
150MP0000049_abnormal_middle_ear0.69021251
151MP0001177_atelectasis0.68256327
152MP0000249_abnormal_blood_vessel0.67391296
153MP0004036_abnormal_muscle_relaxation0.66363065
154MP0003724_increased_susceptibility_to0.65354742
155MP0003448_altered_tumor_morphology0.61826666
156MP0000428_abnormal_craniofacial_morphol0.61516993
157MP0000230_abnormal_systemic_arterial0.61081212
158MP0001614_abnormal_blood_vessel0.60650138
159MP0000747_muscle_weakness0.58814190
160MP0003828_pulmonary_edema0.57250917
161MP0010630_abnormal_cardiac_muscle0.56701799
162MP0002109_abnormal_limb_morphology0.56696363
163MP0010771_integument_phenotype0.56394200
164MP0005084_abnormal_gallbladder_morpholo0.54599378
165MP0003091_abnormal_cell_migration0.53912035
166MP0003011_delayed_dark_adaptation0.53717083
167MP0009053_abnormal_anal_canal0.52700356
168MP0004215_abnormal_myocardial_fiber0.52027361
169MP0004145_abnormal_muscle_electrophysio0.50950795
170MP0002106_abnormal_muscle_physiology0.50805834
171MP0000266_abnormal_heart_morphology0.49427324
172MP0004085_abnormal_heartbeat0.49138131
173MP0005375_adipose_tissue_phenotype0.48587652

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.63254966
2Premature rupture of membranes (HP:0001788)7.05266079
3Broad metatarsal (HP:0001783)6.12261500
4Ankle contracture (HP:0006466)5.44025106
5Shallow orbits (HP:0000586)5.03509377
6Vertebral compression fractures (HP:0002953)4.70211999
7Aortic dissection (HP:0002647)4.62319660
8Soft skin (HP:0000977)4.42912714
9Wrist flexion contracture (HP:0001239)4.39892572
10Cervical subluxation (HP:0003308)4.31767850
11Cerebral aneurysm (HP:0004944)4.29946952
12Dilatation of the ascending aorta (HP:0005111)4.26226654
13Bladder diverticulum (HP:0000015)4.10258685
14Biconcave vertebral bodies (HP:0004586)4.07718845
15Aortic aneurysm (HP:0004942)4.05596010
16Pancreatic cysts (HP:0001737)4.00552565
17Atrophic scars (HP:0001075)3.93660987
18Pancreatic fibrosis (HP:0100732)3.88789138
19Type 1 muscle fiber predominance (HP:0003803)3.88693870
20Fragile skin (HP:0001030)3.85071062
21Follicular hyperkeratosis (HP:0007502)3.83597089
22Molar tooth sign on MRI (HP:0002419)3.74867671
23Abnormality of midbrain morphology (HP:0002418)3.74867671
24Congenital stationary night blindness (HP:0007642)3.69842039
25Abnormality of dentin (HP:0010299)3.67908185
26Chronic hepatic failure (HP:0100626)3.58465170
27Spinal rigidity (HP:0003306)3.56876945
28Increased connective tissue (HP:0009025)3.50974989
29Blue sclerae (HP:0000592)3.48715882
30Wormian bones (HP:0002645)3.41342405
31Keratoconus (HP:0000563)3.34788517
32Increased corneal curvature (HP:0100692)3.34788517
33True hermaphroditism (HP:0010459)3.31949413
34Mitral valve prolapse (HP:0001634)3.19088632
35Pulmonary artery stenosis (HP:0004415)3.14345457
36Nephronophthisis (HP:0000090)3.13880881
37Type II lissencephaly (HP:0007260)2.97561400
38Peritonitis (HP:0002586)2.97335441
39Acute necrotizing encephalopathy (HP:0006965)2.95283962
40Increased variability in muscle fiber diameter (HP:0003557)2.94536599
41Hyperextensible skin (HP:0000974)2.93895268
42Medial flaring of the eyebrow (HP:0010747)2.90884277
43Neonatal short-limb short stature (HP:0008921)2.88167446
44Vascular tortuosity (HP:0004948)2.82345911
45Round ear (HP:0100830)2.81244607
46Nonimmune hydrops fetalis (HP:0001790)2.80705455
47Thin bony cortex (HP:0002753)2.80338704
48Cystic liver disease (HP:0006706)2.79992187
49Abnormal delivery (HP:0001787)2.75114418
50Distal arthrogryposis (HP:0005684)2.73141624
51Attenuation of retinal blood vessels (HP:0007843)2.72767698
52Occipital encephalocele (HP:0002085)2.71834207
53Mitochondrial inheritance (HP:0001427)2.69256286
54Abnormality of skeletal muscle fiber size (HP:0012084)2.69225252
55Genu recurvatum (HP:0002816)2.69100162
56Pendular nystagmus (HP:0012043)2.67149018
57Abnormality of the renal medulla (HP:0100957)2.65002465
58Cerebellar dysplasia (HP:0007033)2.62847117
59Progressive macrocephaly (HP:0004481)2.61304117
60Slender build (HP:0001533)2.59980656
61Hyperventilation (HP:0002883)2.59504131
62Mildly elevated creatine phosphokinase (HP:0008180)2.54647499
63Overgrowth (HP:0001548)2.54530820
64Abnormality of the labia minora (HP:0012880)2.53872981
65Camptodactyly of toe (HP:0001836)2.52973703
66Joint laxity (HP:0001388)2.52750179
67Mitral stenosis (HP:0001718)2.52632627
68Sclerocornea (HP:0000647)2.51185193
69Mitral regurgitation (HP:0001653)2.50243913
70Methylmalonic acidemia (HP:0002912)2.49769058
71Acute encephalopathy (HP:0006846)2.48037959
72Abnormal rod and cone electroretinograms (HP:0008323)2.47733190
73Abnormal mitochondria in muscle tissue (HP:0008316)2.47209246
74Gait imbalance (HP:0002141)2.46559501
75Type 2 muscle fiber atrophy (HP:0003554)2.44924006
76Alopecia of scalp (HP:0002293)2.44077028
77Bowel diverticulosis (HP:0005222)2.42339962
78Wide anterior fontanel (HP:0000260)2.41692583
79Narrow nasal bridge (HP:0000446)2.40754044
80Abnormality of the acetabulum (HP:0003170)2.40547223
81Congenital primary aphakia (HP:0007707)2.38221901
82Bell-shaped thorax (HP:0001591)2.36953271
83Beaking of vertebral bodies (HP:0004568)2.36860033
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.36418093
85Aneurysm (HP:0002617)2.34675645
86Spondylolisthesis (HP:0003302)2.33707710
87Aortic valve stenosis (HP:0001650)2.32717469
88Absent speech (HP:0001344)2.32354642
89Tubular atrophy (HP:0000092)2.32033634
90Abnormality of alanine metabolism (HP:0010916)2.31257956
91Hyperalaninemia (HP:0003348)2.31257956
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31257956
93Hip contracture (HP:0003273)2.30146896
94Large for gestational age (HP:0001520)2.29753569
95Striae distensae (HP:0001065)2.29387660
96Increased CSF lactate (HP:0002490)2.27442174
97Delayed closure of the anterior fontanelle (HP:0001476)2.26099500
98Abnormal drinking behavior (HP:0030082)2.25818589
99Polydipsia (HP:0001959)2.25818589
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.25103065
101Osteolytic defects of the hand bones (HP:0009699)2.25103065
102Abnormality of the renal cortex (HP:0011035)2.24720023
103Inability to walk (HP:0002540)2.21134596
104Anencephaly (HP:0002323)2.20883699
105Progressive inability to walk (HP:0002505)2.20406890
106Osteopenia (HP:0000938)2.20349188
107Hemiparesis (HP:0001269)2.19464398
108Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18581552
109Muscle fiber splitting (HP:0003555)2.17566765
110Rib fusion (HP:0000902)2.17294704
111Generalized amyotrophy (HP:0003700)2.17008612
112Nephrogenic diabetes insipidus (HP:0009806)2.16832843
113Abnormal biliary tract physiology (HP:0012439)2.14906482
114Bile duct proliferation (HP:0001408)2.14906482
115Severe muscular hypotonia (HP:0006829)2.14768844
116Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14453908
117Disproportionate short-trunk short stature (HP:0003521)2.13593888
118Ectopia lentis (HP:0001083)2.13291232
119Redundant skin (HP:0001582)2.13230340
120Broad-based gait (HP:0002136)2.12439072
121Arterial tortuosity (HP:0005116)2.11933959
122Lipid accumulation in hepatocytes (HP:0006561)2.10100064
123Methylmalonic aciduria (HP:0012120)2.09905765
124Right ventricular cardiomyopathy (HP:0011663)2.09755677
125Carpal bone hypoplasia (HP:0001498)2.09238235
126Coronal craniosynostosis (HP:0004440)2.08547195
127Gingival overgrowth (HP:0000212)2.06542891
128Optic disc pallor (HP:0000543)2.06353333
129Flat cornea (HP:0007720)2.05538363
130Joint stiffness (HP:0001387)2.05003841
131Decreased central vision (HP:0007663)2.04531663
132Delayed cranial suture closure (HP:0000270)2.04181988
133Limited hip movement (HP:0008800)2.02729691
134Ulnar deviation of the wrist (HP:0003049)2.02597382
135Tarsal synostosis (HP:0008368)2.01998650
136Inguinal hernia (HP:0000023)2.01239143
137Disproportionate tall stature (HP:0001519)2.00351651
138Short hallux (HP:0010109)2.00317639
139Genital tract atresia (HP:0001827)1.98578897
140Increased hepatocellular lipid droplets (HP:0006565)1.96774168
141Lipoatrophy (HP:0100578)1.95654515
142Calf muscle hypertrophy (HP:0008981)1.95488759
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.95302211
144Abnormality of the pons (HP:0007361)1.94734827
145Chorioretinal atrophy (HP:0000533)1.94177231
146Hypoplasia of the pons (HP:0012110)1.93899723
147Polyuria (HP:0000103)1.93099516
148Retinal dysplasia (HP:0007973)1.93062264
149Adrenal hypoplasia (HP:0000835)1.92696254
150Congenital, generalized hypertrichosis (HP:0004540)1.91467134
151Absent phalangeal crease (HP:0006109)1.91461076
152Venous insufficiency (HP:0005293)1.89347761
153Neoplasm of head and neck (HP:0012288)1.89085523
154Esophageal neoplasm (HP:0100751)1.89085523
155Fetal akinesia sequence (HP:0001989)1.88470039
156Muscle fiber atrophy (HP:0100295)1.87858620
157Elbow flexion contracture (HP:0002987)1.87736790
158Renal Fanconi syndrome (HP:0001994)1.87003769
159Vaginal atresia (HP:0000148)1.86438029
160Venous abnormality (HP:0002624)1.86105519
161Joint contractures involving the joints of the feet (HP:0100492)1.85958083
162Flexion contracture of toe (HP:0005830)1.85958083
163Abnormality of the calf musculature (HP:0001430)1.85489475
164Subacute progressive viral hepatitis (HP:0006572)1.84705930
165Broad ribs (HP:0000885)1.83249664
166Irregular vertebral endplates (HP:0003301)1.83072734
167Breech presentation (HP:0001623)1.81762533
168Aplasia of the musculature (HP:0100854)1.80588235
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.79817522
170Short tibia (HP:0005736)1.79808117
171Hyperglycinemia (HP:0002154)1.79713981
172Aortic regurgitation (HP:0001659)1.79549115
173Thin skin (HP:0000963)1.78654698
174Systemic lupus erythematosus (HP:0002725)1.78033197
175Anterior segment dysgenesis (HP:0007700)1.77904298
176Synostosis involving bones of the lower limbs (HP:0009138)1.77817087
177Synostosis involving bones of the feet (HP:0009140)1.77817087
178Optic nerve hypoplasia (HP:0000609)1.76755286
179Aplasia/Hypoplasia of the hallux (HP:0008362)1.76713206
180Limb dystonia (HP:0002451)1.76589454
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75746476
182Gastrointestinal infarctions (HP:0005244)1.75595448
183Abolished electroretinogram (ERG) (HP:0000550)1.73880728
184Postaxial hand polydactyly (HP:0001162)1.73046610
185Knee flexion contracture (HP:0006380)1.72515312
1863-Methylglutaconic aciduria (HP:0003535)1.71207373
187Lissencephaly (HP:0001339)1.70309453
188Furrowed tongue (HP:0000221)1.69782524
189Mesangial abnormality (HP:0001966)1.69608920
190Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68978724
191Left ventricular hypertrophy (HP:0001712)1.68845522
192Small hand (HP:0200055)1.68787954
193Congenital hepatic fibrosis (HP:0002612)1.68426425
194Hypoproteinemia (HP:0003075)1.67702144
195Prolonged QT interval (HP:0001657)1.67245889
196Bulbous nose (HP:0000414)1.66729344
197Corneal dystrophy (HP:0001131)1.64082757
198Skin nodule (HP:0200036)1.63692880
199Osteoarthritis (HP:0002758)1.61877347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L3.67371860
2TRIB33.39192874
3TGFBR23.30728665
4MYLK3.26536006
5ADRBK23.05800344
6PDGFRA3.00664694
7STK242.89549137
8EPHB22.87617577
9TTN2.82722735
10MAP4K22.78726118
11TIE12.78023765
12LATS22.75948265
13GRK12.68285149
14WNK42.68284015
15DDR22.65238848
16ERN12.38393734
17TLK12.29711767
18PTK62.23965855
19ERBB32.20048955
20DMPK1.97812869
21FER1.97650744
22PIM21.93759327
23WNK31.87322063
24PKN21.86838462
25INSRR1.84590095
26CASK1.80567721
27ILK1.73677682
28BMPR1B1.70520019
29NME11.68959618
30MAP3K41.64575493
31VRK21.60024667
32PTK2B1.57147927
33MUSK1.50483850
34STK391.50179525
35STK161.46089322
36MAPK131.44928452
37MAPKAPK31.34985119
38TRPM71.32314986
39BCKDK1.30576565
40TESK11.29244789
41TRIM281.28456165
42PAK31.26234920
43CSNK1G21.22663335
44NME21.21733034
45CAMKK21.21633526
46ROCK11.21427357
47PAK21.21379130
48DYRK21.20285420
49ZAK1.19479762
50PHKG11.19174100
51PHKG21.19174100
52MARK11.15857168
53DAPK21.14805544
54PIK3CA1.14319268
55BMPR21.13286495
56CSNK1G11.12182607
57CSNK1G31.11963536
58MET1.11426729
59DAPK31.08842202
60EPHA31.06448159
61LIMK11.05921647
62ARAF1.04265568
63VRK11.03102167
64ACVR1B1.00282368
65LMTK20.99779840
66LATS10.98824425
67STK30.95920744
68MAP2K20.95441724
69NEK90.94100153
70SIK10.93208315
71KDR0.92995720
72NTRK20.92794756
73MST1R0.92604184
74TXK0.92507334
75TAOK30.92449688
76MST40.92395933
77PRKCG0.92258737
78GRK50.92200459
79PRKCH0.91651507
80CSNK1A1L0.91243134
81BMX0.91197148
82MAP2K70.88707936
83PIK3CG0.88682946
84BCR0.88428127
85TAF10.88399225
86MAP2K10.88058883
87OXSR10.87652648
88ROCK20.86787039
89FRK0.84892596
90PRKD10.83756296
91MAP3K70.83306670
92PTK20.82102220
93PDK20.76438592
94NUAK10.74641217
95NTRK10.72961300
96CCNB10.72489758
97MAP3K30.71074946
98PDGFRB0.70850734
99PRKD20.68044622
100ABL20.67295186
101PAK40.66215909
102MAP3K120.64195453
103MOS0.63658292
104PLK20.63575692
105PINK10.63273316
106FGFR40.62936885
107PDK40.62083453
108PDK30.62083453
109LRRK20.60767933
110MAPK70.60765112
111TEC0.59871614
112CAMK2A0.59067164
113NTRK30.59052686
114CDC42BPA0.57989670
115GRK70.56948996
116TNIK0.56356489
117PRKACA0.56233070
118RAF10.51527000
119TGFBR10.50326319
120OBSCN0.49872487
121PRKAA20.49057036
122EPHB10.48979797
123KIT0.48583216
124CAMK10.47557608
125EIF2AK30.47328310
126PRKCQ0.47028425
127MAPK150.46694927
128TAOK20.46516502
129PRKD30.45951817
130RPS6KA50.45648605
131PRKCE0.45486098
132CSNK1A10.45382993
133PRKCA0.43740971
134PRKCI0.43430103
135ITK0.42985351
136RPS6KA40.42447370
137BRSK20.41535543
138RIPK10.41223496
139PAK10.40806322
140AKT20.39734430
141PAK60.39644039
142PRKAA10.38963058
143MINK10.38724552
144PLK30.38423470
145STK380.38301862
146PRKG10.38213728
147BUB10.37322189
148CSNK1D0.36162463
149PKN10.34866775
150CAMKK10.34405483
151FGFR10.33761806
152STK110.33311139
153IKBKB0.32680051
154MAPK120.32074959
155SRC0.31510731
156MAP3K10.31336625
157INSR0.30483146
158GSK3A0.29736550
159MAPKAPK20.29601383
160JAK30.29152845
161ADRBK10.27656050
162MAP3K50.27471981
163PRPF4B0.25779423
164CAMK2D0.25314437

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.21605855
2Phototransduction_Homo sapiens_hsa047443.06265033
3Focal adhesion_Homo sapiens_hsa045102.88747772
4Protein digestion and absorption_Homo sapiens_hsa049742.87936670
5Oxidative phosphorylation_Homo sapiens_hsa001902.74093207
6Protein export_Homo sapiens_hsa030602.68809908
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.65672683
8Dilated cardiomyopathy_Homo sapiens_hsa054142.55703875
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.54062559
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46471889
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.36320181
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35365507
13Amoebiasis_Homo sapiens_hsa051462.32949709
14Linoleic acid metabolism_Homo sapiens_hsa005912.19144507
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15870899
16Parkinsons disease_Homo sapiens_hsa050122.10565189
17TGF-beta signaling pathway_Homo sapiens_hsa043502.10226026
18Nitrogen metabolism_Homo sapiens_hsa009102.09074821
19Malaria_Homo sapiens_hsa051442.08685993
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99403959
21Proteoglycans in cancer_Homo sapiens_hsa052051.85940383
22Selenocompound metabolism_Homo sapiens_hsa004501.73116169
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72538634
24Ether lipid metabolism_Homo sapiens_hsa005651.69890636
25RNA polymerase_Homo sapiens_hsa030201.60291667
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55465737
27Complement and coagulation cascades_Homo sapiens_hsa046101.52370845
28Homologous recombination_Homo sapiens_hsa034401.51072732
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.48653444
30Nicotine addiction_Homo sapiens_hsa050331.47002493
31Huntingtons disease_Homo sapiens_hsa050161.46879202
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45858545
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44732304
34Basal transcription factors_Homo sapiens_hsa030221.43866205
35Fanconi anemia pathway_Homo sapiens_hsa034601.41863223
36Starch and sucrose metabolism_Homo sapiens_hsa005001.41505667
37Hedgehog signaling pathway_Homo sapiens_hsa043401.37721266
38Basal cell carcinoma_Homo sapiens_hsa052171.35767030
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35392559
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31788735
41Caffeine metabolism_Homo sapiens_hsa002321.28932472
42Bladder cancer_Homo sapiens_hsa052191.27756497
43Viral myocarditis_Homo sapiens_hsa054161.27324635
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.21144093
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18959119
46Small cell lung cancer_Homo sapiens_hsa052221.18501138
47Sulfur metabolism_Homo sapiens_hsa009201.17931319
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.14993705
49Olfactory transduction_Homo sapiens_hsa047401.13730208
50One carbon pool by folate_Homo sapiens_hsa006701.12895191
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12872071
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.12711962
53Glutathione metabolism_Homo sapiens_hsa004801.09645921
54Sulfur relay system_Homo sapiens_hsa041221.09595932
55Hippo signaling pathway_Homo sapiens_hsa043901.08915125
56Fatty acid degradation_Homo sapiens_hsa000711.07780148
57Taste transduction_Homo sapiens_hsa047421.05903213
58Arachidonic acid metabolism_Homo sapiens_hsa005901.04946745
59Pathways in cancer_Homo sapiens_hsa052001.04663677
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.04337737
61Insulin secretion_Homo sapiens_hsa049111.04293651
62Peroxisome_Homo sapiens_hsa041460.99731455
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.98952459
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96596533
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95145381
66TNF signaling pathway_Homo sapiens_hsa046680.95012498
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94421507
68Cardiac muscle contraction_Homo sapiens_hsa042600.93389531
69Proteasome_Homo sapiens_hsa030500.93362719
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93242406
71Arginine and proline metabolism_Homo sapiens_hsa003300.91701749
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91460773
73PPAR signaling pathway_Homo sapiens_hsa033200.90878935
74Regulation of autophagy_Homo sapiens_hsa041400.90873630
75Galactose metabolism_Homo sapiens_hsa000520.89693133
76Morphine addiction_Homo sapiens_hsa050320.89515566
77Chronic myeloid leukemia_Homo sapiens_hsa052200.88823754
78Collecting duct acid secretion_Homo sapiens_hsa049660.87473624
79Adherens junction_Homo sapiens_hsa045200.87155053
80Prion diseases_Homo sapiens_hsa050200.86846724
81Toxoplasmosis_Homo sapiens_hsa051450.85051222
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83551050
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83503956
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80278151
85Primary immunodeficiency_Homo sapiens_hsa053400.78131701
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77512069
87Rap1 signaling pathway_Homo sapiens_hsa040150.77127470
88Melanoma_Homo sapiens_hsa052180.76898135
89Chemical carcinogenesis_Homo sapiens_hsa052040.76189955
90ABC transporters_Homo sapiens_hsa020100.74049035
91MicroRNAs in cancer_Homo sapiens_hsa052060.73777411
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73648522
93RNA degradation_Homo sapiens_hsa030180.72214379
94Fatty acid metabolism_Homo sapiens_hsa012120.71686220
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71062416
96Steroid biosynthesis_Homo sapiens_hsa001000.71020326
97Prostate cancer_Homo sapiens_hsa052150.70876375
98Propanoate metabolism_Homo sapiens_hsa006400.70504029
99Gap junction_Homo sapiens_hsa045400.70500016
100Metabolic pathways_Homo sapiens_hsa011000.70333976
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69152917
102Insulin resistance_Homo sapiens_hsa049310.68815782
103beta-Alanine metabolism_Homo sapiens_hsa004100.68480357
104Platelet activation_Homo sapiens_hsa046110.67406427
105Thyroid hormone synthesis_Homo sapiens_hsa049180.67288945
106Fat digestion and absorption_Homo sapiens_hsa049750.65808488
107Folate biosynthesis_Homo sapiens_hsa007900.65737661
108Ras signaling pathway_Homo sapiens_hsa040140.65500865
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65383490
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65360660
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.65274416
112Ovarian steroidogenesis_Homo sapiens_hsa049130.62982359
113Calcium signaling pathway_Homo sapiens_hsa040200.62968418
114Tryptophan metabolism_Homo sapiens_hsa003800.62536194
115Circadian rhythm_Homo sapiens_hsa047100.62495253
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61521117
117Cocaine addiction_Homo sapiens_hsa050300.61465362
118Retinol metabolism_Homo sapiens_hsa008300.60971403
119Butanoate metabolism_Homo sapiens_hsa006500.60467889
120Renin-angiotensin system_Homo sapiens_hsa046140.58880448
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58876212
122Purine metabolism_Homo sapiens_hsa002300.58855554
123Rheumatoid arthritis_Homo sapiens_hsa053230.57244179
124Serotonergic synapse_Homo sapiens_hsa047260.56952149
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56451859
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56386743
127Mineral absorption_Homo sapiens_hsa049780.56046164
128Salivary secretion_Homo sapiens_hsa049700.55589594
129Phagosome_Homo sapiens_hsa041450.52754399
130Glioma_Homo sapiens_hsa052140.52222598
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51345578
132Pyrimidine metabolism_Homo sapiens_hsa002400.50251116
133GABAergic synapse_Homo sapiens_hsa047270.50157139
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49855587
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48830653
136Melanogenesis_Homo sapiens_hsa049160.48362316
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47950688
138Glutamatergic synapse_Homo sapiens_hsa047240.47920213
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47792903
140Circadian entrainment_Homo sapiens_hsa047130.47658066
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.47085330
142Pertussis_Homo sapiens_hsa051330.46858923
143Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46594444
144Histidine metabolism_Homo sapiens_hsa003400.46319151
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45831831
146Apoptosis_Homo sapiens_hsa042100.45691431
147Sphingolipid metabolism_Homo sapiens_hsa006000.44793759
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.44264627
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43751047
150Estrogen signaling pathway_Homo sapiens_hsa049150.43740172
151GnRH signaling pathway_Homo sapiens_hsa049120.43110183
152Dorso-ventral axis formation_Homo sapiens_hsa043200.42524697
153Tight junction_Homo sapiens_hsa045300.41694452
154Vibrio cholerae infection_Homo sapiens_hsa051100.41118853
155Pancreatic cancer_Homo sapiens_hsa052120.41035088
156Fructose and mannose metabolism_Homo sapiens_hsa000510.40842539
157Fatty acid elongation_Homo sapiens_hsa000620.40099053
158Axon guidance_Homo sapiens_hsa043600.39666493
159Wnt signaling pathway_Homo sapiens_hsa043100.39179260
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38490851
161Nucleotide excision repair_Homo sapiens_hsa034200.38216623
162Vitamin B6 metabolism_Homo sapiens_hsa007500.37819506
163Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37260134
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35677416
165Alzheimers disease_Homo sapiens_hsa050100.34948677
166Renin secretion_Homo sapiens_hsa049240.34770264
167Shigellosis_Homo sapiens_hsa051310.33989004

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