ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K36 demethylation (GO:0070544)	5.52726652
2	peptidyl-lysine dimethylation (GO:0018027)	5.13474161
3	histone H3-K9 demethylation (GO:0033169)	4.94882162
4	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.94436481
5	sperm motility (GO:0030317)	4.84786783
6	fusion of sperm to egg plasma membrane (GO:0007342)	4.65441949
7	definitive hemopoiesis (GO:0060216)	4.47983624
8	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.30567410
9	acrosome reaction (GO:0007340)	4.30467457
10	insulin-like growth factor receptor signaling pathway (GO:0048009)	4.28046420
11	histone lysine demethylation (GO:0070076)	4.25057963
12	histone demethylation (GO:0016577)	3.97943353
13	cellular zinc ion homeostasis (GO:0006882)	3.90499283
14	stress granule assembly (GO:0034063)	3.78016255
15	sperm capacitation (GO:0048240)	3.76482225
16	nucleosome disassembly (GO:0006337)	3.71530066
17	protein-DNA complex disassembly (GO:0032986)	3.71530066
18	receptor recycling (GO:0001881)	3.61011114
19	iron ion import (GO:0097286)	3.59175228
20	protein demethylation (GO:0006482)	3.54753955
21	protein dealkylation (GO:0008214)	3.54753955
22	cranial nerve morphogenesis (GO:0021602)	3.53802043
23	coenzyme catabolic process (GO:0009109)	3.46438603
24	zinc ion homeostasis (GO:0055069)	3.44282339
25	carnitine shuttle (GO:0006853)	3.41361349
26	face development (GO:0060324)	3.40947945
27	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.40744113
28	plasma membrane fusion (GO:0045026)	3.37983892
29	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.36630017
30	multicellular organism reproduction (GO:0032504)	3.33626374
31	motile cilium assembly (GO:0044458)	3.33125195
32	cilium or flagellum-dependent cell motility (GO:0001539)	3.31531109
33	regulation of ARF GTPase activity (GO:0032312)	3.31095642
34	establishment of protein localization to Golgi (GO:0072600)	3.28147207
35	nuclear pore complex assembly (GO:0051292)	3.27316828
36	protein targeting to Golgi (GO:0000042)	3.20255815
37	TOR signaling (GO:0031929)	3.14862246
38	regulation of autophagic vacuole assembly (GO:2000785)	3.14268419
39	COPII vesicle coating (GO:0048208)	3.14222373
40	spermatid development (GO:0007286)	3.02411009
41	spermatid nucleus differentiation (GO:0007289)	2.99291212
42	carnitine transmembrane transport (GO:1902603)	2.97891389
43	carnitine transport (GO:0015879)	2.94643356
44	amino-acid betaine transport (GO:0015838)	2.94643356
45	reproduction (GO:0000003)	2.92746766
46	protein retention in ER lumen (GO:0006621)	2.91503369
47	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.90679503
48	positive regulation of glycolytic process (GO:0045821)	2.89605039
49	myofibril assembly (GO:0030239)	2.86051752
50	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.82864200
51	positive regulation of CREB transcription factor activity (GO:0032793)	2.81972510
52	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.81740740
53	positive regulation of catecholamine secretion (GO:0033605)	2.80548321
54	biotin metabolic process (GO:0006768)	2.77545752
55	negative regulation of erythrocyte differentiation (GO:0045647)	2.76837357
56	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.76413946
57	regulation of histone H3-K27 methylation (GO:0061085)	2.76177534
58	negative regulation of JNK cascade (GO:0046329)	2.68822879
59	centriole assembly (GO:0098534)	2.68302064
60	COPI coating of Golgi vesicle (GO:0048205)	2.67147478
61	Golgi transport vesicle coating (GO:0048200)	2.67147478
62	thyroid gland development (GO:0030878)	2.66629503
63	diacylglycerol metabolic process (GO:0046339)	2.65369199
64	regulation of vacuole organization (GO:0044088)	2.62902076
65	cardiac myofibril assembly (GO:0055003)	2.62256466
66	regulation of Rab GTPase activity (GO:0032313)	2.61995616
67	positive regulation of Rab GTPase activity (GO:0032851)	2.61995616
68	response to muscle activity (GO:0014850)	2.61904833
69	single fertilization (GO:0007338)	2.61025461
70	cytoplasmic mRNA processing body assembly (GO:0033962)	2.60086326
71	receptor catabolic process (GO:0032801)	2.59647083
72	coronary vasculature morphogenesis (GO:0060977)	2.59147574
73	histone lysine methylation (GO:0034968)	2.58952054
74	phosphatidylethanolamine metabolic process (GO:0046337)	2.56754938
75	quaternary ammonium group transport (GO:0015697)	2.55472342
76	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.53961608
77	nucleus organization (GO:0006997)	2.53452025
78	Golgi to endosome transport (GO:0006895)	2.52989924
79	androgen biosynthetic process (GO:0006702)	2.50023909
80	sperm-egg recognition (GO:0035036)	2.49936133
81	melanin metabolic process (GO:0006582)	2.49462846
82	regulation of ARF protein signal transduction (GO:0032012)	2.48478948
83	cardiac muscle hypertrophy (GO:0003300)	2.46687346
84	striated muscle hypertrophy (GO:0014897)	2.46161135
85	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.45616580
86	muscle hypertrophy in response to stress (GO:0003299)	2.45616580
87	cardiac muscle adaptation (GO:0014887)	2.45616580
88	binding of sperm to zona pellucida (GO:0007339)	2.45477615
89	fatty acid transmembrane transport (GO:1902001)	2.44822398
90	axonemal dynein complex assembly (GO:0070286)	2.44406212
91	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.40897693
92	histone H3-K9 methylation (GO:0051567)	2.40544618
93	negative regulation of stress-activated MAPK cascade (GO:0032873)	2.39912908
94	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	2.39912908
95	protein localization to synapse (GO:0035418)	2.39889362
96	melanin biosynthetic process (GO:0042438)	2.38926205
97	sexual reproduction (GO:0019953)	2.38383429
98	histone H3-K9 modification (GO:0061647)	2.38125372
99	regulation of nucleobase-containing compound transport (GO:0032239)	2.36672520
100	ribosome assembly (GO:0042255)	2.35569692

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.71648914
2	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.62415614
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.60605535
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.24943221
5	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.56873660
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.35386823
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.30586716
8	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.26735658
9	KDM2B_26808549_Chip-Seq_DND41_Human	2.25556158
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.21654892
11	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.18998815
12	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.10685331
13	SMC4_20622854_ChIP-Seq_HELA_Human	2.06580082
14	PKCTHETA_26484144_Chip-Seq_BREAST_Human	2.03589470
15	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.03185910
16	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.00817402
17	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.99443248
18	MYC_22102868_ChIP-Seq_BL_Human	1.95779992
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.92099658
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.84206065
21	TCF7_22412390_ChIP-Seq_EML_Mouse	1.83167259
22	CHD1_26751641_Chip-Seq_LNCaP_Human	1.81368853
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.80706793
24	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.78054608
25	E2F7_22180533_ChIP-Seq_HELA_Human	1.77061271
26	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.71217975
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.66614490
28	SPI1_23127762_ChIP-Seq_K562_Human	1.65468758
29	AHR_22903824_ChIP-Seq_MCF-7_Human	1.65144883
30	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.63193000
31	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.62620660
32	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60482886
33	CREB1_26743006_Chip-Seq_LNCaP_Human	1.60290103
34	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.59089354
35	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.56790189
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.55026873
37	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.52119729
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.48410585
39	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.47972107
40	SCL_19346495_ChIP-Seq_HPC-7_Human	1.46684722
41	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46242940
42	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.42344494
43	ZNF263_19887448_ChIP-Seq_K562_Human	1.41720634
44	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.41071265
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40965874
46	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40059891
47	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.36316400
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.35211442
49	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.33427175
50	MYB_26560356_Chip-Seq_TH1_Human	1.33147485
51	KDM2B_26808549_Chip-Seq_K562_Human	1.32412544
52	MAF_26560356_Chip-Seq_TH2_Human	1.32228692
53	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.31349595
54	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.28861365
55	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.28030161
56	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.27406170
57	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.24584717
58	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.24280660
59	CTCF_27219007_Chip-Seq_Bcells_Human	1.23864996
60	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.23737367
61	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.23219283
62	UTX_26944678_Chip-Seq_JUKART_Human	1.22925858
63	RAC3_21632823_ChIP-Seq_H3396_Human	1.21830067
64	VDR_24763502_ChIP-Seq_THP-1_Human	1.20436807
65	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.20243797
66	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.19675897
67	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.19663884
68	RACK7_27058665_Chip-Seq_MCF-7_Human	1.16946160
69	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.15668981
70	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.13860307
71	KDM5A_27292631_Chip-Seq_BREAST_Human	1.11825239
72	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.11639254
73	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.11377868
74	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10729334
75	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.10108587
76	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.08053313
77	GATA2_19941826_ChIP-Seq_K562_Human	1.07186561
78	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.06313161
79	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.04479624
80	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04271328
81	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.03640625
82	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.03451007
83	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02790095
84	TP63_22573176_ChIP-Seq_HFKS_Human	1.02303792
85	MITF_21258399_ChIP-Seq_MELANOMA_Human	1.01402904
86	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.00956279
87	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.00072272
88	ERA_21632823_ChIP-Seq_H3396_Human	0.98909645
89	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.98746855
90	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.98438445
91	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.98081279
92	GATA6_25053715_ChIP-Seq_YYC3_Human	0.97718188
93	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.97108261
94	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.96593590
95	RXR_22108803_ChIP-Seq_LS180_Human	0.95953843
96	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.95782177
97	GATA1_22025678_ChIP-Seq_K562_Human	0.94673549
98	P68_20966046_ChIP-Seq_HELA_Human	0.94099702
99	MAF_26560356_Chip-Seq_TH1_Human	0.93476848
100	GATA1_19941826_ChIP-Seq_K562_Human	0.92967612

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	7.89320192
2	MP0005410_abnormal_fertilization	3.78493585
3	MP0005451_abnormal_body_composition	3.42136997
4	MP0002009_preneoplasia	3.03442991
5	MP0004233_abnormal_muscle_weight	2.76904473
6	MP0008057_abnormal_DNA_replication	2.67400353
7	MP0002132_abnormal_respiratory_system	2.56210925
8	MP0005409_darkened_coat_color	2.55169500
9	MP0002249_abnormal_larynx_morphology	2.40297963
10	MP0004381_abnormal_hair_follicle	2.36976276
11	MP0003123_paternal_imprinting	2.18322772
12	MP0003315_abnormal_perineum_morphology	2.15831066
13	MP0004084_abnormal_cardiac_muscle	1.98380781
14	MP0003172_abnormal_lysosome_physiology	1.94671638
15	MP0004036_abnormal_muscle_relaxation	1.93013458
16	MP0003763_abnormal_thymus_physiology	1.74144368
17	MP0002166_altered_tumor_susceptibility	1.73216854
18	MP0008004_abnormal_stomach_pH	1.72423847
19	MP0003698_abnormal_male_reproductive	1.72145687
20	MP0005058_abnormal_lysosome_morphology	1.60961562
21	MP0004264_abnormal_extraembryonic_tissu	1.55074933
22	MP0003868_abnormal_feces_composition	1.54758639
23	MP0001929_abnormal_gametogenesis	1.53377728
24	MP0005670_abnormal_white_adipose	1.51603454
25	MP0002108_abnormal_muscle_morphology	1.49457873
26	MP0009697_abnormal_copulation	1.48108048
27	MP0005408_hypopigmentation	1.47414103
28	MP0005248_abnormal_Harderian_gland	1.43611170
29	MP0000747_muscle_weakness	1.42414473
30	MP0005360_urolithiasis	1.40599955
31	MP0005666_abnormal_adipose_tissue	1.40362598
32	MP0009780_abnormal_chondrocyte_physiolo	1.39195057
33	MP0002638_abnormal_pupillary_reflex	1.38384783
34	MP0001661_extended_life_span	1.35985224
35	MP0005394_taste/olfaction_phenotype	1.31574154
36	MP0005499_abnormal_olfactory_system	1.31574154
37	MP0000749_muscle_degeneration	1.29687169
38	MP0009115_abnormal_fat_cell	1.29526558
39	MP0002160_abnormal_reproductive_system	1.29418304
40	MP0005377_hearing/vestibular/ear_phenot	1.28964803
41	MP0003878_abnormal_ear_physiology	1.28964803
42	MP0002269_muscular_atrophy	1.24089734
43	MP0000015_abnormal_ear_pigmentation	1.19543080
44	MP0001270_distended_abdomen	1.17665258
45	MP0004858_abnormal_nervous_system	1.16030958
46	MP0003656_abnormal_erythrocyte_physiolo	1.07260774
47	MP0002396_abnormal_hematopoietic_system	1.07049802
48	MP0000003_abnormal_adipose_tissue	1.04429661
49	MP0005375_adipose_tissue_phenotype	1.03565544
50	MP0003045_fibrosis	1.02716128
51	MP0000759_abnormal_skeletal_muscle	1.00251091
52	MP0003136_yellow_coat_color	0.99067038
53	MP0003879_abnormal_hair_cell	0.97137977
54	MP0008007_abnormal_cellular_replicative	0.96144233
55	MP0003385_abnormal_body_wall	0.95932298
56	MP0004087_abnormal_muscle_fiber	0.95840638
57	MP0005085_abnormal_gallbladder_physiolo	0.93809437
58	MP0002161_abnormal_fertility/fecundity	0.91042947
59	MP0003183_abnormal_peptide_metabolism	0.90028773
60	MP0002970_abnormal_white_adipose	0.86394481
61	MP0004085_abnormal_heartbeat	0.86111299
62	MP0002971_abnormal_brown_adipose	0.85478568
63	MP0005220_abnormal_exocrine_pancreas	0.84842873
64	MP0010329_abnormal_lipoprotein_level	0.82928669
65	MP0010630_abnormal_cardiac_muscle	0.82608797
66	MP0001502_abnormal_circadian_rhythm	0.82288333
67	MP0003122_maternal_imprinting	0.81283742
68	MP0003191_abnormal_cellular_cholesterol	0.81276662
69	MP0006138_congestive_heart_failure	0.80669073
70	MP0004134_abnormal_chest_morphology	0.79701845
71	MP0000372_irregular_coat_pigmentation	0.79143560
72	MP0004808_abnormal_hematopoietic_stem	0.78209939
73	MP0000681_abnormal_thyroid_gland	0.76837546
74	MP0005397_hematopoietic_system_phenotyp	0.75215063
75	MP0001545_abnormal_hematopoietic_system	0.75215063
76	MP0001944_abnormal_pancreas_morphology	0.75023538
77	MP0002127_abnormal_cardiovascular_syste	0.74814673
78	MP0001984_abnormal_olfaction	0.73818884
79	MP0000733_abnormal_muscle_development	0.73583524
80	MP0001849_ear_inflammation	0.71797986
81	MP0001764_abnormal_homeostasis	0.71524498
82	MP0004272_abnormal_basement_membrane	0.70585990
83	MP0000371_diluted_coat_color	0.70120870
84	MP0002078_abnormal_glucose_homeostasis	0.69575807
85	MP0001188_hyperpigmentation	0.68177563
86	MP0001664_abnormal_digestion	0.67133215
87	MP0008961_abnormal_basal_metabolism	0.65630918
88	MP0008789_abnormal_olfactory_epithelium	0.64183765
89	MP0001145_abnormal_male_reproductive	0.63550342
90	MP0002089_abnormal_postnatal_growth/wei	0.62557488
91	MP0004145_abnormal_muscle_electrophysio	0.61865858
92	MP0000703_abnormal_thymus_morphology	0.61702045
93	MP0002184_abnormal_innervation	0.60782534
94	MP0005187_abnormal_penis_morphology	0.60758521
95	MP0001666_abnormal_nutrient_absorption	0.60665940
96	MP0000609_abnormal_liver_physiology	0.60590445
97	MP0003077_abnormal_cell_cycle	0.59080350
98	MP0002229_neurodegeneration	0.58945709
99	MP0008438_abnormal_cutaneous_collagen	0.56500005
100	MP0003121_genomic_imprinting	0.55906897

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	4.26095391
2	Abnormality of the columella (HP:0009929)	3.79656416
3	Menstrual irregularities (HP:0000858)	3.74081643
4	Resting tremor (HP:0002322)	3.48528255
5	Abnormality of the intrinsic pathway (HP:0010989)	3.34501797
6	Reduced antithrombin III activity (HP:0001976)	3.15630264
7	Thoracic kyphosis (HP:0002942)	3.15523437
8	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.03060172
9	Renovascular hypertension (HP:0100817)	2.97807944
10	Exercise-induced myalgia (HP:0003738)	2.97406262
11	Sparse lateral eyebrow (HP:0005338)	2.96702983
12	Colitis (HP:0002583)	2.94072472
13	Acute hepatic failure (HP:0006554)	2.90901609
14	Abnormality of the thoracic spine (HP:0100711)	2.88008028
15	Truncal obesity (HP:0001956)	2.85424975
16	Abnormality of the fingertips (HP:0001211)	2.83236220
17	Hyporeflexia of lower limbs (HP:0002600)	2.81524211
18	Tubulointerstitial nephritis (HP:0001970)	2.77397785
19	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.64143749
20	Germ cell neoplasia (HP:0100728)	2.62999774
21	Self-mutilation (HP:0000742)	2.54424875
22	Abnormality of the ischium (HP:0003174)	2.54075834
23	Asymmetric septal hypertrophy (HP:0001670)	2.52092968
24	Prolonged partial thromboplastin time (HP:0003645)	2.39418489
25	Right ventricular cardiomyopathy (HP:0011663)	2.38371962
26	Postural instability (HP:0002172)	2.35873163
27	Heterotopia (HP:0002282)	2.33667989
28	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.31487966
29	Inflammation of the large intestine (HP:0002037)	2.30725962
30	Hypoplastic ischia (HP:0003175)	2.30324910
31	Dysmetric saccades (HP:0000641)	2.29363524
32	Bell-shaped thorax (HP:0001591)	2.26343832
33	Flat acetabular roof (HP:0003180)	2.23641159
34	Cutaneous melanoma (HP:0012056)	2.22760053
35	Termporal pattern (HP:0011008)	2.19669663
36	Insidious onset (HP:0003587)	2.19669663
37	Gastrointestinal inflammation (HP:0004386)	2.18035546
38	Joint hemorrhage (HP:0005261)	2.14900997
39	Obstructive sleep apnea (HP:0002870)	2.11316449
40	Hyperkalemia (HP:0002153)	2.06590026
41	Deep palmar crease (HP:0006191)	2.04939766
42	Hyperacusis (HP:0010780)	2.03637630
43	Gingival bleeding (HP:0000225)	2.02729276
44	Rhabdomyolysis (HP:0003201)	2.00875823
45	Bilateral sensorineural hearing impairment (HP:0008619)	1.98938448
46	Acute myeloid leukemia (HP:0004808)	1.97506357
47	Asymmetry of the thorax (HP:0001555)	1.97269671
48	Myoglobinuria (HP:0002913)	1.96233663
49	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.94785161
50	Hypoalphalipoproteinemia (HP:0003233)	1.94375364
51	Testicular neoplasm (HP:0010788)	1.92398785
52	Precocious puberty (HP:0000826)	1.90865954
53	Sudden death (HP:0001699)	1.90765618
54	Anteriorly placed anus (HP:0001545)	1.90698142
55	Obsessive-compulsive behavior (HP:0000722)	1.88850951
56	Hypercholesterolemia (HP:0003124)	1.87226783
57	Ankyloglossia (HP:0010296)	1.84212027
58	Hypolipoproteinemia (HP:0010981)	1.83623634
59	Abnormality of the pubic bones (HP:0003172)	1.83447096
60	Blue irides (HP:0000635)	1.83144935
61	Enlarged kidneys (HP:0000105)	1.82696701
62	Fatigue (HP:0012378)	1.81976339
63	Abnormality of the common coagulation pathway (HP:0010990)	1.79643645
64	Epiphyseal dysplasia (HP:0002656)	1.79460151
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78723310
66	Absent/shortened dynein arms (HP:0200106)	1.78723310
67	Hypoplasia of the thymus (HP:0000778)	1.77481954
68	Tapered finger (HP:0001182)	1.77133788
69	Lower limb hyperreflexia (HP:0002395)	1.76742053
70	Broad nasal tip (HP:0000455)	1.76319858
71	Capillary hemangiomas (HP:0005306)	1.76106348
72	Sensory axonal neuropathy (HP:0003390)	1.74602564
73	Hepatitis (HP:0012115)	1.74546199
74	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.74331556
75	Severe short stature (HP:0003510)	1.73321783
76	Flared iliac wings (HP:0002869)	1.72104225
77	Ventricular fibrillation (HP:0001663)	1.71563037
78	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.67275076
79	Abnormal tarsal ossification (HP:0008369)	1.66986997
80	Poikiloderma (HP:0001029)	1.66457850
81	Hemorrhage of the eye (HP:0011885)	1.65762966
82	Hypobetalipoproteinemia (HP:0003563)	1.65060568
83	Calf muscle hypertrophy (HP:0008981)	1.64734311
84	Acute lymphatic leukemia (HP:0006721)	1.64655095
85	Urinary urgency (HP:0000012)	1.63619789
86	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.63146397
87	Hypoparathyroidism (HP:0000829)	1.62052671
88	Macroorchidism (HP:0000053)	1.59060175
89	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.57948010
90	Infertility (HP:0000789)	1.57912224
91	Open mouth (HP:0000194)	1.57457985
92	Seborrheic dermatitis (HP:0001051)	1.57209016
93	Difficulty running (HP:0009046)	1.57036075
94	Abnormality of the lumbar spine (HP:0100712)	1.56702109
95	Underdeveloped nasal alae (HP:0000430)	1.55248203
96	Ketoacidosis (HP:0001993)	1.55056904
97	Distal lower limb amyotrophy (HP:0008944)	1.54808263
98	Prominent nose (HP:0000448)	1.54762659
99	Acanthocytosis (HP:0001927)	1.52444342
100	Truncal ataxia (HP:0002078)	1.50453443

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.27494126
2	ICK	3.64056962
3	AKT3	3.62399126
4	CDK12	3.39765926
5	MARK3	3.18047358
6	TRIB3	3.09907627
7	PRKD3	2.93488378
8	EEF2K	2.71310840
9	LATS1	2.25597209
10	PKN2	2.01019902
11	OBSCN	1.93159192
12	FGFR4	1.84955747
13	BRD4	1.84643724
14	CAMK1G	1.78123272
15	MAP3K10	1.73290454
16	SIK2	1.68485561
17	TNK2	1.65390995
18	CDK3	1.60482230
19	CAMK1D	1.58557702
20	PLK4	1.55206707
21	FGFR3	1.54044647
22	PRPF4B	1.46423853
23	CSNK1A1L	1.45378069
24	RET	1.34588903
25	MAP2K7	1.34455582
26	SIK1	1.31131172
27	MAP3K2	1.30438976
28	NEK2	1.27743061
29	SGK223	1.22769575
30	SGK494	1.22769575
31	SCYL2	1.20152018
32	STK38	1.18003690
33	MTOR	1.17142858
34	MAPK11	1.16699382
35	NME2	1.10289381
36	SGK2	1.09494628
37	RIPK1	1.06292292
38	MAP3K13	1.05220673
39	CSNK1G3	1.03054012
40	PDPK1	1.02965542
41	WNK1	1.00859170
42	BLK	0.96118317
43	MARK2	0.94160960
44	PDK1	0.93810556
45	DDR2	0.93164041
46	KSR2	0.92124981
47	CAMKK1	0.91324784
48	INSRR	0.90595285
49	SGK3	0.89757473
50	STK38L	0.87983274
51	LMTK2	0.87053032
52	RPS6KB1	0.86731679
53	NLK	0.84827248
54	EPHB1	0.81732933
55	MAP3K1	0.81416305
56	TESK1	0.76241825
57	LATS2	0.75316203
58	CSNK1G1	0.74713579
59	MAPK12	0.72967002
60	SIK3	0.71813240
61	PRKAA1	0.70975875
62	ZAP70	0.67904137
63	FGFR2	0.66973614
64	PIK3CG	0.66151264
65	CDK7	0.65094913
66	CSNK1G2	0.60698086
67	ERN1	0.60544971
68	MST1R	0.55593824
69	BTK	0.55506285
70	IRAK2	0.54491576
71	MAP3K7	0.53509945
72	PRKAA2	0.51832066
73	CDC42BPA	0.49214665
74	EPHA3	0.49177770
75	RPS6KB2	0.47610812
76	CAMK4	0.47221962
77	PASK	0.46562851
78	EIF2AK1	0.40842322
79	ATM	0.40008399
80	HIPK2	0.38672354
81	EIF2AK3	0.38622447
82	GRK6	0.37295262
83	MAPK10	0.36656382
84	SYK	0.36254466
85	GSK3B	0.34953732
86	TRPM7	0.34791908
87	NEK6	0.33557482
88	PDGFRA	0.30892667
89	CDK2	0.29851842
90	ATR	0.29592849
91	SGK1	0.27565274
92	TYRO3	0.27482248
93	PHKG2	0.27315560
94	PHKG1	0.27315560
95	MAPK1	0.26161647
96	MAP3K6	0.24765224
97	NEK9	0.24009382
98	BRSK1	0.24000186
99	MYLK	0.23465647
100	FRK	0.22764775

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	2.37200841
2	Non-small cell lung cancer_Homo sapiens_hsa05223	2.13329517
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.11956011
4	Endometrial cancer_Homo sapiens_hsa05213	2.06172828
5	mTOR signaling pathway_Homo sapiens_hsa04150	1.85166874
6	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.80864974
7	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.80832863
8	Acute myeloid leukemia_Homo sapiens_hsa05221	1.78750479
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.76514645
10	Glucagon signaling pathway_Homo sapiens_hsa04922	1.70958914
11	Lysine degradation_Homo sapiens_hsa00310	1.69506974
12	Circadian rhythm_Homo sapiens_hsa04710	1.56859027
13	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.56310017
14	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.40539008
15	Insulin signaling pathway_Homo sapiens_hsa04910	1.40086860
16	Renin secretion_Homo sapiens_hsa04924	1.39254783
17	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.31338131
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.31036594
19	Insulin resistance_Homo sapiens_hsa04931	1.28763161
20	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.28425252
21	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.28232582
22	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.27426687
23	Glioma_Homo sapiens_hsa05214	1.26592133
24	Butanoate metabolism_Homo sapiens_hsa00650	1.25822572
25	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.25478636
26	Long-term potentiation_Homo sapiens_hsa04720	1.24457229
27	Prostate cancer_Homo sapiens_hsa05215	1.24066924
28	Choline metabolism in cancer_Homo sapiens_hsa05231	1.21638008
29	Complement and coagulation cascades_Homo sapiens_hsa04610	1.19506459
30	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.18139424
31	Type II diabetes mellitus_Homo sapiens_hsa04930	1.17862256
32	Other glycan degradation_Homo sapiens_hsa00511	1.16133183
33	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.14304957
34	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.10567513
35	Gap junction_Homo sapiens_hsa04540	1.10353914
36	Estrogen signaling pathway_Homo sapiens_hsa04915	1.09662661
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.05684411
38	Thyroid cancer_Homo sapiens_hsa05216	1.04545087
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04094257
40	Pancreatic cancer_Homo sapiens_hsa05212	1.02579194
41	ABC transporters_Homo sapiens_hsa02010	1.00568724
42	VEGF signaling pathway_Homo sapiens_hsa04370	0.95819045
43	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.93254612
44	Tyrosine metabolism_Homo sapiens_hsa00350	0.92565624
45	ErbB signaling pathway_Homo sapiens_hsa04012	0.91557264
46	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.91291722
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.90584033
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89981962
49	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87307488
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86992655
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86922847
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.86389096
53	AMPK signaling pathway_Homo sapiens_hsa04152	0.86308118
54	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.85618182
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.84149631
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79035277
57	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.77862674
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.77429595
59	Cholinergic synapse_Homo sapiens_hsa04725	0.77224653
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.76635792
61	Salivary secretion_Homo sapiens_hsa04970	0.76078486
62	FoxO signaling pathway_Homo sapiens_hsa04068	0.74772541
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.74467215
64	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.72798330
65	Colorectal cancer_Homo sapiens_hsa05210	0.72414495
66	Apoptosis_Homo sapiens_hsa04210	0.71985385
67	GnRH signaling pathway_Homo sapiens_hsa04912	0.71335533
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70638972
69	Prolactin signaling pathway_Homo sapiens_hsa04917	0.67692727
70	Alcoholism_Homo sapiens_hsa05034	0.67346797
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66704690
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66575161
73	Gastric acid secretion_Homo sapiens_hsa04971	0.66419986
74	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.65259057
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.65074408
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64435989
77	Hepatitis B_Homo sapiens_hsa05161	0.63738781
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63349782
79	Platelet activation_Homo sapiens_hsa04611	0.63296391
80	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.62979601
81	Melanogenesis_Homo sapiens_hsa04916	0.62543268
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61264650
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.60549284
84	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.60192110
85	Bile secretion_Homo sapiens_hsa04976	0.59870215
86	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57149615
87	Renal cell carcinoma_Homo sapiens_hsa05211	0.56976123
88	Pentose phosphate pathway_Homo sapiens_hsa00030	0.56229649
89	Amphetamine addiction_Homo sapiens_hsa05031	0.53958762
90	Circadian entrainment_Homo sapiens_hsa04713	0.53466782
91	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.53123865
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.52403123
93	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.51871914
94	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.50481614
95	Insulin secretion_Homo sapiens_hsa04911	0.47137805
96	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.45926860
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44623304
98	Fatty acid degradation_Homo sapiens_hsa00071	0.44076944
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43535241
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.43461320

C1QTNF3-AMACR

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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