C1QTNF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.71079796
2cardiac myofibril assembly (GO:0055003)6.15176935
3fatty acid transmembrane transport (GO:1902001)6.02625886
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.84339615
5plasma membrane repair (GO:0001778)5.72982538
6myofibril assembly (GO:0030239)5.68636194
7actin-myosin filament sliding (GO:0033275)5.59726952
8muscle filament sliding (GO:0030049)5.59726952
9tricarboxylic acid cycle (GO:0006099)5.55898188
10carnitine shuttle (GO:0006853)5.54326973
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.40181711
12regulation of skeletal muscle contraction (GO:0014819)5.22218055
13regulation of sequestering of triglyceride (GO:0010889)5.19953316
14negative regulation of potassium ion transmembrane transport (GO:1901380)5.12628436
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.98117339
16regulation of relaxation of muscle (GO:1901077)4.92241502
17regulation of actin filament-based movement (GO:1903115)4.91544408
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.86751577
19heart trabecula formation (GO:0060347)4.83328994
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.81737414
21cardiac muscle contraction (GO:0060048)4.75917916
22actin-mediated cell contraction (GO:0070252)4.59120509
23regulation of acyl-CoA biosynthetic process (GO:0050812)4.38858221
24cardiac muscle cell development (GO:0055013)4.38819600
25cilium or flagellum-dependent cell motility (GO:0001539)4.34953227
26actomyosin structure organization (GO:0031032)4.30990680
27cellular ketone body metabolic process (GO:0046950)4.24182123
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.21016777
29carnitine transmembrane transport (GO:1902603)4.20639075
30low-density lipoprotein particle clearance (GO:0034383)4.20322851
31cardiac cell development (GO:0055006)4.18673721
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.16103120
33cardiac muscle tissue morphogenesis (GO:0055008)4.11696509
34sarcoplasmic reticulum calcium ion transport (GO:0070296)4.08421258
35regulation of cell communication by electrical coupling (GO:0010649)4.04472419
36vascular endothelial growth factor signaling pathway (GO:0038084)4.04056046
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.01524442
38ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.96186984
39glomerular filtration (GO:0003094)3.95925391
40ventricular cardiac muscle cell action potential (GO:0086005)3.93413836
41regulation of coenzyme metabolic process (GO:0051196)3.93378169
42regulation of cofactor metabolic process (GO:0051193)3.93378169
43response to pheromone (GO:0019236)3.92424748
44creatine metabolic process (GO:0006600)3.91614746
45striated muscle contraction (GO:0006941)3.91085941
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.86377932
47amino-acid betaine transport (GO:0015838)3.83450907
48carnitine transport (GO:0015879)3.83450907
49cardiac muscle hypertrophy (GO:0003300)3.82823149
50ketone body metabolic process (GO:1902224)3.80611505
51NADH metabolic process (GO:0006734)3.78011215
52regulation of fatty acid oxidation (GO:0046320)3.76004885
53muscle tissue morphogenesis (GO:0060415)3.75123111
54striated muscle hypertrophy (GO:0014897)3.72232710
55adult heart development (GO:0007512)3.72026990
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.70944728
57fatty acid beta-oxidation (GO:0006635)3.67641508
58regulation of striated muscle contraction (GO:0006942)3.66781029
59regulation of the force of heart contraction (GO:0002026)3.66487906
60behavioral response to nicotine (GO:0035095)3.65619266
61regulation of sarcomere organization (GO:0060297)3.65400897
622-oxoglutarate metabolic process (GO:0006103)3.64929104
63regulation of cardiac muscle cell contraction (GO:0086004)3.61467307
64actin filament-based movement (GO:0030048)3.55650195
65replication fork processing (GO:0031297)3.52195575
66heart contraction (GO:0060047)3.51425447
67heart process (GO:0003015)3.51425447
68regulation of membrane repolarization (GO:0060306)3.50393911
69renal filtration (GO:0097205)3.50350197
70negative regulation of potassium ion transport (GO:0043267)3.49732568
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48232129
72indole-containing compound catabolic process (GO:0042436)3.46228205
73indolalkylamine catabolic process (GO:0046218)3.46228205
74tryptophan catabolic process (GO:0006569)3.46228205
75hindbrain development (GO:0030902)3.45684403
76platelet dense granule organization (GO:0060155)3.41787544
77lymph vessel development (GO:0001945)3.41045622
78signal peptide processing (GO:0006465)3.39581214
79cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.39179937
80synapsis (GO:0007129)3.36636205
81response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.34257221
82positive regulation of lipid storage (GO:0010884)3.33728303
83indolalkylamine metabolic process (GO:0006586)3.32403434
84inositol phosphate catabolic process (GO:0071545)3.30916857
85axoneme assembly (GO:0035082)3.30860927
86regulation of sulfur metabolic process (GO:0042762)3.29398779
87transcytosis (GO:0045056)3.29091885
88seminiferous tubule development (GO:0072520)3.28579650
89presynaptic membrane assembly (GO:0097105)3.28141479
90muscle hypertrophy (GO:0014896)3.26785413
91regulation of cholesterol storage (GO:0010885)3.26582935
92gas transport (GO:0015669)3.23534196
93regulation of p38MAPK cascade (GO:1900744)3.23479629
94positive regulation of fatty acid oxidation (GO:0046321)3.20704622
95photoreceptor cell maintenance (GO:0045494)3.19552799
96kynurenine metabolic process (GO:0070189)3.18011716
97biotin metabolic process (GO:0006768)3.17193934
98glycerophospholipid catabolic process (GO:0046475)3.16958314
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14472598
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14177626
101cell communication involved in cardiac conduction (GO:0086065)3.10641371
102detection of light stimulus involved in visual perception (GO:0050908)3.09711029
103detection of light stimulus involved in sensory perception (GO:0050962)3.09711029
104reflex (GO:0060004)3.09483519
105proline transport (GO:0015824)3.08823063
106brown fat cell differentiation (GO:0050873)3.07680248
107ovulation from ovarian follicle (GO:0001542)3.04615115
108succinate metabolic process (GO:0006105)3.04578493
109lipid particle organization (GO:0034389)3.04020679
110skeletal muscle contraction (GO:0003009)3.02185413
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.01554723
112L-fucose catabolic process (GO:0042355)3.00297009
113fucose catabolic process (GO:0019317)3.00297009
114L-fucose metabolic process (GO:0042354)3.00297009
115respiratory chain complex IV assembly (GO:0008535)3.00153485
116regulation of cardiac muscle contraction (GO:0055117)2.99838442
117fatty acid catabolic process (GO:0009062)2.98840608
118protein K11-linked deubiquitination (GO:0035871)2.98543640
119fatty acid oxidation (GO:0019395)2.98383765
120respiratory electron transport chain (GO:0022904)2.98060895
121epithelial cilium movement (GO:0003351)2.97954506
122valine metabolic process (GO:0006573)2.97878799
123polyol catabolic process (GO:0046174)2.97769711
124negative regulation of nitric-oxide synthase activity (GO:0051001)2.97602130
125cardiac muscle cell action potential involved in contraction (GO:0086002)2.97435349
126protein prenylation (GO:0018342)2.97250766
127prenylation (GO:0097354)2.97250766
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96273556
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96015040
130negative regulation of translation, ncRNA-mediated (GO:0040033)2.96015040
131regulation of translation, ncRNA-mediated (GO:0045974)2.96015040
132muscle contraction (GO:0006936)2.95970693
133intracellular lipid transport (GO:0032365)2.94645610
134tryptophan metabolic process (GO:0006568)2.94465306
135cardiac muscle cell action potential (GO:0086001)2.94194563
136trabecula formation (GO:0060343)2.93670640
137tricarboxylic acid metabolic process (GO:0072350)2.92766134
138lipid oxidation (GO:0034440)2.91756572
139oxaloacetate metabolic process (GO:0006107)2.90834771
140retinal cone cell development (GO:0046549)2.90244290
141electron transport chain (GO:0022900)2.89274399
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87702295
143cytochrome complex assembly (GO:0017004)2.83887749
144neural tube formation (GO:0001841)2.83615521
145neuronal action potential (GO:0019228)2.81548243
146DNA double-strand break processing (GO:0000729)2.78485002
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77569586
148protein complex biogenesis (GO:0070271)2.74820006
149nonmotile primary cilium assembly (GO:0035058)2.71697989
150cilium organization (GO:0044782)2.71443038
151cornea development in camera-type eye (GO:0061303)2.71032095
152dopamine transport (GO:0015872)2.70867240
153auditory receptor cell stereocilium organization (GO:0060088)2.70474765
154cilium assembly (GO:0042384)2.70105233
155cilium morphogenesis (GO:0060271)2.68792256
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.68540719
157presynaptic membrane organization (GO:0097090)2.67787764
158cellular response to ATP (GO:0071318)2.66764992
159intraciliary transport (GO:0042073)2.64595811
160centriole replication (GO:0007099)2.64413187
161somatic hypermutation of immunoglobulin genes (GO:0016446)2.62486628
162somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62486628
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61498160
164thyroid hormone metabolic process (GO:0042403)2.61491408
165piRNA metabolic process (GO:0034587)2.60958576
166water-soluble vitamin biosynthetic process (GO:0042364)2.60390688
167indole-containing compound metabolic process (GO:0042430)2.60015877
168phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59919992
169inositol phosphate dephosphorylation (GO:0046855)2.59919992
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.59866137
171protein-cofactor linkage (GO:0018065)2.57939750
172inner ear receptor stereocilium organization (GO:0060122)2.55825792
173alanine transport (GO:0032328)2.54713117
174protein localization to cilium (GO:0061512)2.54511925
175double-strand break repair via homologous recombination (GO:0000724)2.52456589
176recombinational repair (GO:0000725)2.51434839
177insulin secretion (GO:0030073)2.50697496
178positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.50121756
179DNA deamination (GO:0045006)2.50078877
180righting reflex (GO:0060013)2.49487014
181protein polyglutamylation (GO:0018095)2.47713292
182rhodopsin mediated signaling pathway (GO:0016056)2.47339734
183single strand break repair (GO:0000012)2.47040294
184positive regulation of cAMP-mediated signaling (GO:0043950)2.46707285
185peptidyl-histidine modification (GO:0018202)2.46521138
186startle response (GO:0001964)2.46001104
187mitochondrial respiratory chain complex I assembly (GO:0032981)2.45614999
188NADH dehydrogenase complex assembly (GO:0010257)2.45614999
189mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45614999
190mitochondrial respiratory chain complex assembly (GO:0033108)2.45156517
191ubiquinone biosynthetic process (GO:0006744)2.43407940
192regulation of cilium movement (GO:0003352)2.42404097
193regulation of hexokinase activity (GO:1903299)2.41464602
194regulation of glucokinase activity (GO:0033131)2.41464602
195neuronal action potential propagation (GO:0019227)2.41370546
196aromatic amino acid family catabolic process (GO:0009074)2.41130908
197cellular response to sterol (GO:0036315)2.40051411
198cilium movement (GO:0003341)2.39378874
199C4-dicarboxylate transport (GO:0015740)2.37541143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.54472781
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.14331605
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.06710855
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.55506067
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.47361497
6GBX2_23144817_ChIP-Seq_PC3_Human3.35099955
7ZNF274_21170338_ChIP-Seq_K562_Hela3.34991520
8CLOCK_20551151_ChIP-Seq_293T_Human3.11371222
9* TBX20_22328084_ChIP-Seq_HEART_Mouse3.07584602
10* TBX20_22080862_ChIP-Seq_HEART_Mouse3.07584602
11IGF1R_20145208_ChIP-Seq_DFB_Human3.02551607
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00951907
13VDR_22108803_ChIP-Seq_LS180_Human2.97850713
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83564381
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71702028
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70498459
17GATA1_22025678_ChIP-Seq_K562_Human2.67332354
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.64194501
19ZNF263_19887448_ChIP-Seq_K562_Human2.61088311
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.55867591
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53038218
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32007079
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27984393
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27711632
25ESR1_20079471_ChIP-ChIP_T-47D_Human2.25974924
26EZH2_22144423_ChIP-Seq_EOC_Human2.25235067
27FUS_26573619_Chip-Seq_HEK293_Human2.24237283
28TAF15_26573619_Chip-Seq_HEK293_Human2.23364899
29GATA2_21666600_ChIP-Seq_HMVEC_Human2.22421166
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14497632
31* P300_19829295_ChIP-Seq_ESCs_Human2.10853845
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09507529
33ER_23166858_ChIP-Seq_MCF-7_Human2.09077125
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08828389
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07984064
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.99920712
37EWS_26573619_Chip-Seq_HEK293_Human1.97995630
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93666835
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.93265867
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93005719
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86995451
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.84173805
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82748545
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81795539
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80079832
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79970707
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.79117715
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77498275
49SMAD4_21799915_ChIP-Seq_A2780_Human1.74802124
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.65926567
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.63664958
52STAT3_23295773_ChIP-Seq_U87_Human1.63127565
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62474106
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61352392
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.60890960
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.60876059
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60469982
58* AR_25329375_ChIP-Seq_VCAP_Human1.60342593
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60278491
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59406341
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58466942
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57163352
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56940483
64CBP_20019798_ChIP-Seq_JUKART_Human1.53993816
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53993816
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52434947
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51596339
68TCF4_23295773_ChIP-Seq_U87_Human1.49790550
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49012362
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48760825
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47803640
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45984062
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44988911
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.42197043
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42030176
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41774936
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41419162
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41315079
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.36782045
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.35749620
81NANOG_19829295_ChIP-Seq_ESCs_Human1.35093055
82SOX2_19829295_ChIP-Seq_ESCs_Human1.35093055
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34879258
84TCF4_22108803_ChIP-Seq_LS180_Human1.34691936
85TP53_22573176_ChIP-Seq_HFKS_Human1.33828032
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33118387
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33071474
88RUNX2_22187159_ChIP-Seq_PCA_Human1.31630199
89GATA4_21415370_ChIP-Seq_HL-1_Mouse1.30946735
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.29363504
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.29030193
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28701801
93IRF1_19129219_ChIP-ChIP_H3396_Human1.28564821
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28233291
95GATA1_19941826_ChIP-Seq_K562_Human1.27686143
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26654035
97* CJUN_26792858_Chip-Seq_BT549_Human1.26189516
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.25994056
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24635937
100RNF2_27304074_Chip-Seq_NSC_Mouse1.23296734
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22621312
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22593984
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22593984
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21882032
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.21882032
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21593465
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21449130
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19929234
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18978937
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18835092
111AR_21572438_ChIP-Seq_LNCaP_Human1.18353426
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18154176
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17887539
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15886377
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15880297
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.15654779
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.15112872
118HTT_18923047_ChIP-ChIP_STHdh_Human1.14604996
119KDM2B_26808549_Chip-Seq_DND41_Human1.14514297
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13836531
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.13250732
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13060149
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12905844
124MYC_18940864_ChIP-ChIP_HL60_Human1.11251414
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10867944
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.09970492
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.09181434
128CDX2_22108803_ChIP-Seq_LS180_Human1.08818908
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.08147517
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07948483
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07316555
132STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07167667
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06289698
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05971130
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05903948
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.05596087
137P53_22387025_ChIP-Seq_ESCs_Mouse1.05552448
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05326432
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05264615
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05153976
141RUNX1_27514584_Chip-Seq_MCF-7_Human1.04348069
142REST_21632747_ChIP-Seq_MESCs_Mouse1.03667734
143RACK7_27058665_Chip-Seq_MCF-7_Human1.03205121
144HOXB7_26014856_ChIP-Seq_BT474_Human1.02333762
145TP63_17297297_ChIP-ChIP_HaCaT_Human1.01628681
146* NCOR_22424771_ChIP-Seq_293T_Human1.01483086
147GATA3_21878914_ChIP-Seq_MCF-7_Human1.00806188
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00229860
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98566921
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.98442841
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.98177130
152AR_20517297_ChIP-Seq_VCAP_Human0.98046086
153* TAL1_26923725_Chip-Seq_HPCs_Mouse0.96811647
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95971242
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95801285
156* LXR_22292898_ChIP-Seq_THP-1_Human0.95750802
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95603925
158DROSHA_22980978_ChIP-Seq_HELA_Human0.95517506
159KDM2B_26808549_Chip-Seq_K562_Human0.95487577
160GATA2_19941826_ChIP-Seq_K562_Human0.92743623
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92689988
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91325533
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91129854
164TP63_22573176_ChIP-Seq_HFKS_Human0.90882488
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.89509063
166* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89084863
167SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88354782
168FOXA2_19822575_ChIP-Seq_HepG2_Human0.88166474
169ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86211177
170STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85839125
171ISL1_27105846_Chip-Seq_CPCs_Mouse0.85635723
172ATF3_27146783_Chip-Seq_COLON_Human0.85256833
173JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83748641
174* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83123152
175CTCF_27219007_Chip-Seq_Bcells_Human0.81854401
176BCAT_22108803_ChIP-Seq_LS180_Human0.81706377
177* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81489260
178TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80749235
179CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80594815
180* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80207380
181NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79440948
182KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78821800
183SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78708284
184SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78620583
185PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78231603
186WT1_19549856_ChIP-ChIP_CCG9911_Human0.78055745
187WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77883043
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76476574
189P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76028521
190ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75572217
191SPI1_20517297_ChIP-Seq_HL60_Human0.74337443
192SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74333448
193SMAD4_21741376_ChIP-Seq_HESCs_Human0.74300634
194SMAD3_21741376_ChIP-Seq_HESCs_Human0.74162952
195* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74000796
196NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73155586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.59196238
2MP0003646_muscle_fatigue4.61405755
3MP0004084_abnormal_cardiac_muscle4.59396632
4MP0000751_myopathy4.58971715
5MP0004215_abnormal_myocardial_fiber4.23147312
6MP0004130_abnormal_muscle_cell3.61927816
7MP0004036_abnormal_muscle_relaxation3.60542716
8MP0000749_muscle_degeneration3.33608549
9MP0005670_abnormal_white_adipose3.33440461
10MP0005330_cardiomyopathy3.26722168
11MP0003195_calcinosis2.80268293
12MP0000750_abnormal_muscle_regeneration2.79807409
13MP0004087_abnormal_muscle_fiber2.77365944
14MP0003828_pulmonary_edema2.65988348
15MP0010368_abnormal_lymphatic_system2.61926717
16MP0005551_abnormal_eye_electrophysiolog2.55085980
17MP0005666_abnormal_adipose_tissue2.54718720
18MP0002972_abnormal_cardiac_muscle2.53958298
19MP0005620_abnormal_muscle_contractility2.44159274
20MP0008775_abnormal_heart_ventricle2.43112012
21MP0001986_abnormal_taste_sensitivity2.40376722
22MP0005385_cardiovascular_system_phenoty2.38507779
23MP0001544_abnormal_cardiovascular_syste2.38507779
24MP0006072_abnormal_retinal_apoptosis2.38256630
25MP0006138_congestive_heart_failure2.31793325
26MP0005646_abnormal_pituitary_gland2.31412957
27MP0004484_altered_response_of2.25031809
28MP0008877_abnormal_DNA_methylation2.22072622
29MP0001968_abnormal_touch/_nociception2.21449100
30MP0010630_abnormal_cardiac_muscle2.21407830
31MP0002106_abnormal_muscle_physiology2.20687928
32MP0004185_abnormal_adipocyte_glucose2.20206251
33MP0002638_abnormal_pupillary_reflex2.13553644
34MP0004145_abnormal_muscle_electrophysio2.13087478
35MP0001501_abnormal_sleep_pattern2.08232661
36MP0003950_abnormal_plasma_membrane2.07312486
37MP0001879_abnormal_lymphatic_vessel2.03237786
38MP0005253_abnormal_eye_physiology2.02454812
39MP0002102_abnormal_ear_morphology2.01858211
40MP0003787_abnormal_imprinting1.96599182
41MP0002876_abnormal_thyroid_physiology1.94609667
42MP0003011_delayed_dark_adaptation1.92817578
43MP0005645_abnormal_hypothalamus_physiol1.92221117
44MP0000759_abnormal_skeletal_muscle1.91289764
45MP0002269_muscular_atrophy1.90666089
46MP0000427_abnormal_hair_cycle1.90378505
47MP0002332_abnormal_exercise_endurance1.88668476
48MP0003137_abnormal_impulse_conducting1.86451452
49MP0005375_adipose_tissue_phenotype1.82838923
50MP0003724_increased_susceptibility_to1.82780587
51MP0000343_altered_response_to1.81518914
52MP0005369_muscle_phenotype1.78187537
53MP0004272_abnormal_basement_membrane1.76275282
54MP0003880_abnormal_central_pattern1.70285532
55MP0005187_abnormal_penis_morphology1.69538332
56MP0004085_abnormal_heartbeat1.68927869
57MP0009046_muscle_twitch1.68303023
58MP0002736_abnormal_nociception_after1.67669318
59MP0000747_muscle_weakness1.67082051
60MP0005167_abnormal_blood-brain_barrier1.65334522
61MP0003136_yellow_coat_color1.61961545
62MP0009745_abnormal_behavioral_response1.61836645
63MP0008872_abnormal_physiological_respon1.61678659
64MP0000372_irregular_coat_pigmentation1.60961031
65MP0005379_endocrine/exocrine_gland_phen1.58928976
66MP0005084_abnormal_gallbladder_morpholo1.56632963
67MP0004885_abnormal_endolymph1.52801813
68MP0001486_abnormal_startle_reflex1.51207029
69MP0000013_abnormal_adipose_tissue1.50154048
70MP0003705_abnormal_hypodermis_morpholog1.49701989
71MP0006276_abnormal_autonomic_nervous1.47723329
72MP0002272_abnormal_nervous_system1.46947725
73MP0006036_abnormal_mitochondrial_physio1.46710663
74MP0008058_abnormal_DNA_repair1.46292067
75MP0004147_increased_porphyrin_level1.44073150
76MP0003221_abnormal_cardiomyocyte_apopto1.43347673
77MP0004133_heterotaxia1.39814241
78MP0002127_abnormal_cardiovascular_syste1.38993428
79MP0004043_abnormal_pH_regulation1.37420346
80MP0005085_abnormal_gallbladder_physiolo1.33154560
81MP0002735_abnormal_chemical_nociception1.32978800
82MP0001919_abnormal_reproductive_system1.32391869
83MP0002163_abnormal_gland_morphology1.32101093
84MP0005389_reproductive_system_phenotype1.31972369
85MP0001764_abnormal_homeostasis1.29375894
86MP0003279_aneurysm1.29147328
87MP0004924_abnormal_behavior1.27695779
88MP0005386_behavior/neurological_phenoty1.27695779
89MP0008438_abnormal_cutaneous_collagen1.26012160
90MP0002254_reproductive_system_inflammat1.24461407
91MP0000003_abnormal_adipose_tissue1.24093425
92MP0000569_abnormal_digit_pigmentation1.23684763
93MP0002693_abnormal_pancreas_physiology1.21451812
94MP0002971_abnormal_brown_adipose1.21157259
95MP0000631_abnormal_neuroendocrine_gland1.18903081
96MP0002160_abnormal_reproductive_system1.17224419
97MP0005165_increased_susceptibility_to1.16002775
98MP0004510_myositis1.15953567
99MP0004233_abnormal_muscle_weight1.15384649
100MP0002064_seizures1.14602473
101MP0003121_genomic_imprinting1.13683820
102MP0002572_abnormal_emotion/affect_behav1.10162589
103MP0008995_early_reproductive_senescence1.10132949
104MP0002557_abnormal_social/conspecific_i1.09753505
105MP0003718_maternal_effect1.08905629
106MP0010386_abnormal_urinary_bladder1.08373969
107MP0002938_white_spotting1.08115604
108MP0004142_abnormal_muscle_tone1.05029591
109MP0000266_abnormal_heart_morphology1.04549732
110MP0001485_abnormal_pinna_reflex1.04434003
111MP0002090_abnormal_vision1.04240464
112MP0003566_abnormal_cell_adhesion1.03977267
113MP0001970_abnormal_pain_threshold1.01671192
114MP0001984_abnormal_olfaction1.00786505
115MP0002139_abnormal_hepatobiliary_system0.99941704
116MP0002108_abnormal_muscle_morphology0.99484631
117MP0003868_abnormal_feces_composition0.96952485
118MP0003698_abnormal_male_reproductive0.96644177
119MP0000538_abnormal_urinary_bladder0.96437359
120MP0001529_abnormal_vocalization0.95972508
121MP0008875_abnormal_xenobiotic_pharmacok0.95906646
122MP0003191_abnormal_cellular_cholesterol0.95400331
123MP0005332_abnormal_amino_acid0.95084656
124MP0000516_abnormal_urinary_system0.95031776
125MP0005367_renal/urinary_system_phenotyp0.95031776
126MP0005365_abnormal_bile_salt0.95002948
127MP0002733_abnormal_thermal_nociception0.94839535
128MP0002067_abnormal_sensory_capabilities0.94282195
129MP0001944_abnormal_pancreas_morphology0.92213325
130MP0002128_abnormal_blood_circulation0.90750281
131MP0000733_abnormal_muscle_development0.89232328
132MP0005410_abnormal_fertilization0.89101765
133MP0001929_abnormal_gametogenesis0.89056495
134MP0005275_abnormal_skin_tensile0.88423629
135MP0002734_abnormal_mechanical_nocicepti0.87548640
136MP0005448_abnormal_energy_balance0.86647608
137MP0005220_abnormal_exocrine_pancreas0.86594162
138MP0003122_maternal_imprinting0.86252764
139MP0004742_abnormal_vestibular_system0.85502314
140MP0000767_abnormal_smooth_muscle0.85279562
141MP0000230_abnormal_systemic_arterial0.84400232
142MP0009278_abnormal_bone_marrow0.84247437
143MP0002653_abnormal_ependyma_morphology0.83982154
144MP0009115_abnormal_fat_cell0.83345081
145MP0009780_abnormal_chondrocyte_physiolo0.77840660
146MP0008961_abnormal_basal_metabolism0.76644344
147MP0003045_fibrosis0.76169186
148MP0005623_abnormal_meninges_morphology0.74396392
149MP0005266_abnormal_metabolism0.71853555
150MP0005334_abnormal_fat_pad0.71331389
151MP0000249_abnormal_blood_vessel0.70753054
152MP0010329_abnormal_lipoprotein_level0.67424963
153MP0005535_abnormal_body_temperature0.65615190
154MP0005319_abnormal_enzyme/_coenzyme0.64892070
155MP0002925_abnormal_cardiovascular_devel0.64442008
156MP0002118_abnormal_lipid_homeostasis0.64367012
157MP0005595_abnormal_vascular_smooth0.63830462
158MP0002078_abnormal_glucose_homeostasis0.63714418
159MP0002909_abnormal_adrenal_gland0.62378554
160MP0001614_abnormal_blood_vessel0.61791114
161MP0001851_eye_inflammation0.61573694
162MP0003567_abnormal_fetal_cardiomyocyte0.60754907
163MP0002295_abnormal_pulmonary_circulatio0.59099893
164MP0002970_abnormal_white_adipose0.55058161
165MP0003303_peritoneal_inflammation0.52917028
166MP0001958_emphysema0.50934733
167MP0003300_gastrointestinal_ulcer0.50422442
168MP0001853_heart_inflammation0.49523713
169MP0006035_abnormal_mitochondrial_morpho0.48113653
170MP0002133_abnormal_respiratory_system0.48069105
171MP0005388_respiratory_system_phenotype0.48069105
172MP0003690_abnormal_glial_cell0.44893634
173MP0003091_abnormal_cell_migration0.43802235
174MP0001784_abnormal_fluid_regulation0.42015622
175MP0002234_abnormal_pharynx_morphology0.41718510
176MP0003948_abnormal_gas_homeostasis0.41173851
177MP0001727_abnormal_embryo_implantation0.38552074
178MP0000609_abnormal_liver_physiology0.37522034
179MP0005452_abnormal_adipose_tissue0.36650912
180MP0002166_altered_tumor_susceptibility0.35096546

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.46528423
2Muscle fiber splitting (HP:0003555)6.21531363
3Ventricular tachycardia (HP:0004756)6.05552679
4Exercise-induced myalgia (HP:0003738)5.83480285
5Calf muscle hypertrophy (HP:0008981)5.76347735
6Muscle hypertrophy of the lower extremities (HP:0008968)5.45246969
7Hyporeflexia of lower limbs (HP:0002600)5.41970368
8Exercise-induced muscle cramps (HP:0003710)5.37857639
9Atrial fibrillation (HP:0005110)5.16257746
10Increased connective tissue (HP:0009025)5.08677681
11Myoglobinuria (HP:0002913)5.00914309
12Difficulty running (HP:0009046)4.85361716
13Primary atrial arrhythmia (HP:0001692)4.80064001
14Lipoatrophy (HP:0100578)4.75993942
15Supraventricular arrhythmia (HP:0005115)4.66890110
16Supraventricular tachycardia (HP:0004755)4.62576835
17Abnormality of the calf musculature (HP:0001430)4.53353425
18Right ventricular cardiomyopathy (HP:0011663)4.32093549
19True hermaphroditism (HP:0010459)4.11344346
20Pancreatic cysts (HP:0001737)4.11066983
21EMG: myopathic abnormalities (HP:0003458)4.09156906
22Pancreatic fibrosis (HP:0100732)4.04166804
23Palpitations (HP:0001962)3.99072511
24Rhabdomyolysis (HP:0003201)3.94610315
25Bundle branch block (HP:0011710)3.91590912
26Subaortic stenosis (HP:0001682)3.87157451
27Abnormality of the left ventricular outflow tract (HP:0011103)3.87157451
28Myotonia (HP:0002486)3.85918080
29Dilated cardiomyopathy (HP:0001644)3.78508945
30Prolonged QT interval (HP:0001657)3.70659749
31Asymmetric septal hypertrophy (HP:0001670)3.59864964
32Syncope (HP:0001279)3.54071528
33Abnormality of midbrain morphology (HP:0002418)3.50950193
34Molar tooth sign on MRI (HP:0002419)3.50950193
35Hyperventilation (HP:0002883)3.50636529
36Difficulty climbing stairs (HP:0003551)3.39656368
37Nephronophthisis (HP:0000090)3.33471046
38Attenuation of retinal blood vessels (HP:0007843)3.30841163
39Increased variability in muscle fiber diameter (HP:0003557)3.30555762
40Heart block (HP:0012722)3.26236244
41Intestinal atresia (HP:0011100)3.21288898
42Muscle fiber inclusion bodies (HP:0100299)3.18983988
43Type 1 muscle fiber predominance (HP:0003803)3.18630596
44Muscle stiffness (HP:0003552)3.18213053
45Renal cortical cysts (HP:0000803)3.14063303
46Abnormality of skeletal muscle fiber size (HP:0012084)3.12758420
47Abnormal atrioventricular conduction (HP:0005150)3.12711088
48Atrioventricular block (HP:0001678)3.12176013
49Congenital stationary night blindness (HP:0007642)3.11045039
50Abnormality of the renal cortex (HP:0011035)3.10850698
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.09172653
52Ventricular arrhythmia (HP:0004308)3.08929572
53Medial flaring of the eyebrow (HP:0010747)2.92962641
54Type II lissencephaly (HP:0007260)2.87455076
55Areflexia of lower limbs (HP:0002522)2.86639306
56Abnormality of the renal medulla (HP:0100957)2.85983151
57Chronic hepatic failure (HP:0100626)2.83840664
58Distal lower limb muscle weakness (HP:0009053)2.82491490
59Enlarged penis (HP:0000040)2.78886792
60Hypoglycemic coma (HP:0001325)2.76888403
61Ketoacidosis (HP:0001993)2.76243239
62Gaze-evoked nystagmus (HP:0000640)2.75784691
63Cystic liver disease (HP:0006706)2.66501036
64Hepatic necrosis (HP:0002605)2.61614037
65Congenital sensorineural hearing impairment (HP:0008527)2.59511802
66Abnormal EKG (HP:0003115)2.55464460
67Nemaline bodies (HP:0003798)2.55046575
68Abolished electroretinogram (ERG) (HP:0000550)2.54306717
69Polycythemia (HP:0001901)2.53702400
70Abnormality of fatty-acid metabolism (HP:0004359)2.51638170
71Neck muscle weakness (HP:0000467)2.51334771
72Facial diplegia (HP:0001349)2.50753305
73Broad metatarsal (HP:0001783)2.48121289
74Ventricular fibrillation (HP:0001663)2.46962428
75Hypothermia (HP:0002045)2.44669539
76Decreased central vision (HP:0007663)2.42793516
77Testicular atrophy (HP:0000029)2.41746641
78Broad-based gait (HP:0002136)2.41482878
79Abnormal respiratory epithelium morphology (HP:0012253)2.39550902
80Abnormal respiratory motile cilium morphology (HP:0005938)2.39550902
81Dicarboxylic aciduria (HP:0003215)2.39455467
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39455467
83Increased muscle lipid content (HP:0009058)2.37527162
84Abnormal mitochondria in muscle tissue (HP:0008316)2.36495679
85Clumsiness (HP:0002312)2.34213760
86Muscular dystrophy (HP:0003560)2.33419098
87Hemiparesis (HP:0001269)2.32956009
88Gait imbalance (HP:0002141)2.31611072
89Sclerocornea (HP:0000647)2.31450980
90Abnormal rod and cone electroretinograms (HP:0008323)2.30662116
91Male pseudohermaphroditism (HP:0000037)2.28355857
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.28298098
93Acute necrotizing encephalopathy (HP:0006965)2.27751045
94Abnormal drinking behavior (HP:0030082)2.24667735
95Polydipsia (HP:0001959)2.24667735
96Limb-girdle muscle atrophy (HP:0003797)2.24635129
97Conjunctival hamartoma (HP:0100780)2.24527310
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.24454815
99Protruding tongue (HP:0010808)2.23192446
100Cerebellar dysplasia (HP:0007033)2.22694045
101Congenital primary aphakia (HP:0007707)2.21860670
102Spinal rigidity (HP:0003306)2.21737850
103Methylmalonic acidemia (HP:0002912)2.20251903
104Hypoplastic ischia (HP:0003175)2.16553746
105Left ventricular hypertrophy (HP:0001712)2.15660951
106Furrowed tongue (HP:0000221)2.15117211
107Ketosis (HP:0001946)2.11854888
108Acute encephalopathy (HP:0006846)2.10187693
109Oligomenorrhea (HP:0000876)2.09846763
110Bony spicule pigmentary retinopathy (HP:0007737)2.09430140
111Palmoplantar keratoderma (HP:0000982)2.09081026
112Hyperglycinuria (HP:0003108)2.09034652
113Insulin-resistant diabetes mellitus (HP:0000831)2.07461309
114Hepatocellular necrosis (HP:0001404)2.07382524
115Congenital hepatic fibrosis (HP:0002612)2.07355576
116Fair hair (HP:0002286)2.05587596
117Lymphangioma (HP:0100764)2.05513240
118Cerebral edema (HP:0002181)2.03409414
119Chronic otitis media (HP:0000389)2.02332245
120Hyperinsulinemic hypoglycemia (HP:0000825)2.02265845
121Increased CSF lactate (HP:0002490)2.01174058
122Generalized muscle weakness (HP:0003324)2.00549007
123Hypoalphalipoproteinemia (HP:0003233)2.00501903
124Acanthosis nigricans (HP:0000956)1.99767751
125Abnormality of the ischium (HP:0003174)1.98861820
126Volvulus (HP:0002580)1.98588089
127Pendular nystagmus (HP:0012043)1.98159752
128Reduced subcutaneous adipose tissue (HP:0003758)1.97445203
129Progressive cerebellar ataxia (HP:0002073)1.97232345
130Bone cyst (HP:0012062)1.97009848
131Toxemia of pregnancy (HP:0100603)1.96801617
132Absent speech (HP:0001344)1.95949935
133Large for gestational age (HP:0001520)1.95286165
134Genital tract atresia (HP:0001827)1.95133664
135Anencephaly (HP:0002323)1.95005469
136Abnormality of vitamin B metabolism (HP:0004340)1.93973635
137Distal lower limb amyotrophy (HP:0008944)1.93775601
138Mildly elevated creatine phosphokinase (HP:0008180)1.93193384
139Inability to walk (HP:0002540)1.92965217
140Nephrogenic diabetes insipidus (HP:0009806)1.92437552
141Progressive macrocephaly (HP:0004481)1.92009629
142Colon cancer (HP:0003003)1.91005800
143Cerebral aneurysm (HP:0004944)1.90991332
144EMG: neuropathic changes (HP:0003445)1.90293395
145Proximal amyotrophy (HP:0007126)1.90035265
146Pancreatic islet-cell hyperplasia (HP:0004510)1.89889323
147Increased corneal curvature (HP:0100692)1.89300954
148Keratoconus (HP:0000563)1.89300954
149Cerebral hemorrhage (HP:0001342)1.89231070
150Round ear (HP:0100830)1.88706330
151Gowers sign (HP:0003391)1.87998107
152Abnormality of the labia minora (HP:0012880)1.87595670
153Tubulointerstitial nephritis (HP:0001970)1.86638436
154Congestive heart failure (HP:0001635)1.86602820
155Optic nerve hypoplasia (HP:0000609)1.86592451
156Hamartoma of the eye (HP:0010568)1.85907383
157Mitochondrial inheritance (HP:0001427)1.85497863
158Focal motor seizures (HP:0011153)1.82563902
159Rimmed vacuoles (HP:0003805)1.82315459
160Abnormal biliary tract physiology (HP:0012439)1.81785380
161Bile duct proliferation (HP:0001408)1.81785380
162Exercise intolerance (HP:0003546)1.81572101
163Abnormality of macular pigmentation (HP:0008002)1.81357641
164Methylmalonic aciduria (HP:0012120)1.81252764
165Vaginal atresia (HP:0000148)1.80921559
166Scapular winging (HP:0003691)1.80021958
167Abnormality of alanine metabolism (HP:0010916)1.79801640
168Hyperalaninemia (HP:0003348)1.79801640
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79801640
170Gonadotropin excess (HP:0000837)1.79286373
171Proximal tubulopathy (HP:0000114)1.79248425
172Gastrointestinal atresia (HP:0002589)1.78960112
173Postaxial foot polydactyly (HP:0001830)1.77283242
1743-Methylglutaconic aciduria (HP:0003535)1.77137007
175Hyperglycemia (HP:0003074)1.76960152
176Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76679429
177Febrile seizures (HP:0002373)1.76514090
178Hypoalbuminemia (HP:0003073)1.74974100
179Abnormal albumin level (HP:0012116)1.74974100
180Lissencephaly (HP:0001339)1.72780903
181Postaxial hand polydactyly (HP:0001162)1.71251979
182Preaxial hand polydactyly (HP:0001177)1.70855888
183Polyuria (HP:0000103)1.69679867
184Lipid accumulation in hepatocytes (HP:0006561)1.67123252
185Severe muscular hypotonia (HP:0006829)1.65960285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.80620645
2TIE15.53947952
3TTN5.42653025
4OBSCN3.75557281
5PHKG13.27066248
6PHKG23.27066248
7CASK3.18323771
8TRIB33.17336362
9PDK33.09430406
10PDK43.09430406
11WNK32.98367861
12MYLK2.87744887
13LMTK22.83709180
14BMPR1B2.58330440
15MAP4K22.58117631
16BCKDK2.55813469
17RIPK12.54572809
18KDR2.53266450
19PDK22.47360085
20PKN22.44099688
21DMPK2.42202513
22ADRBK22.28861494
23GRK12.26610547
24ACVR1B2.24709573
25TGFBR21.92448327
26STK391.87545471
27MAPK131.76598982
28PIK3CA1.69990615
29OXSR11.62797621
30PINK11.60926318
31MAP2K31.51149533
32TRIM281.39609844
33MAP3K31.38140140
34NUAK11.36787816
35TAOK31.34699211
36PNCK1.34100978
37PRKD11.27152363
38MAP3K41.23954187
39TNIK1.23444936
40MARK11.23409745
41EIF2AK31.22879718
42PTK2B1.22716359
43CAMK1D1.22000761
44MAPK121.20997286
45MKNK21.20228675
46NEK11.18702073
47BRSK21.17167084
48MUSK1.14610266
49STK31.13853865
50PRKAA21.13260795
51SIK11.05340779
52EPHB11.04197574
53PDGFRA0.98586042
54NTRK30.96445685
55ERN10.95820084
56MAP3K70.95104704
57TGFBR10.91720821
58DYRK20.90946858
59MST40.90569924
60GRK70.89236484
61TLK10.88886686
62MAPKAPK30.88770614
63MARK30.88030867
64EPHB20.87918794
65PLK40.87411601
66WEE10.87257408
67ILK0.86578056
68CAMK1G0.85280937
69DAPK20.84699899
70NLK0.84665220
71INSRR0.84660626
72PRKAA10.84595002
73TNK20.83931147
74MAP2K70.83402379
75PAK30.83058431
76CSNK1G10.82567389
77TRPM70.77532059
78FER0.76822214
79PLK20.76721764
80STK240.76138056
81ADRBK10.75848943
82FGFR20.74827248
83PRKCG0.73226266
84PTK60.71449536
85EPHA40.71159525
86FGFR40.70207218
87ERBB30.69135791
88CAMK2D0.68997057
89FGFR30.68975947
90VRK10.68682307
91PRKD30.68226415
92CSNK1G30.67915315
93CAMK40.67835301
94CSNK1G20.65165586
95PRKCH0.64561677
96PRKG20.62726345
97JAK10.60545549
98ROCK10.60511420
99SGK20.60253081
100AKT30.55579375
101PDPK10.55561327
102PRKCQ0.51322223
103JAK20.46847399
104CDC42BPA0.45722165
105MKNK10.45635022
106TEC0.45546318
107NME10.45075062
108FLT30.44978803
109MAP2K60.44278622
110CSNK1A1L0.44044174
111ATM0.43385630
112BCR0.43136435
113PLK30.42366003
114PRKG10.42242000
115PDK10.42080598
116PKN10.42073019
117CCNB10.41139018
118PIK3CG0.40805792
119DYRK30.40712687
120NEK90.40606983
121LATS10.40036130
122MAP3K50.39928120
123CSNK1A10.39557234
124ZAK0.38584093
125PRKACB0.37974770
126CDK30.37847139
127MAP3K60.37631233
128IRAK10.37493257
129CAMK10.36322249
130TBK10.36153336
131RET0.35880416
132PRKACG0.35297507
133MAPK70.34830705
134MTOR0.34554681
135MAP3K10.34296607
136GSK3A0.34143338
137GRK50.33721049
138CSK0.33101033
139STK40.32180567
140EPHA30.32012274
141RPS6KL10.31351564
142RPS6KC10.31351564
143RPS6KA50.31199266
144STK380.31155164
145SGK4940.30779970
146SGK2230.30779970
147CAMKK20.30164009
148ROCK20.29994895
149DAPK30.29786238
150AKT20.29096810
151RPS6KB10.28919995
152PLK10.28803788
153STK38L0.28324141
154MAP2K10.27942405
155LRRK20.27633531
156PDGFRB0.27250436
157MAPK40.26947908
158RPS6KA60.26882554
159PRKCE0.26578270
160WNK10.26572358
161CAMK2A0.26564075
162WNK40.26482924
163PRKACA0.25562555
164MAP2K40.24146413
165ICK0.23599149
166LATS20.23135556

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.42288981
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.78609657
3Propanoate metabolism_Homo sapiens_hsa006403.67464033
4Dilated cardiomyopathy_Homo sapiens_hsa054143.04000261
5Fatty acid degradation_Homo sapiens_hsa000712.99094381
6Cardiac muscle contraction_Homo sapiens_hsa042602.96282818
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.90610291
8Phototransduction_Homo sapiens_hsa047442.70673443
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.68934146
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61850215
11Fatty acid metabolism_Homo sapiens_hsa012122.54750852
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30555256
13PPAR signaling pathway_Homo sapiens_hsa033202.28663182
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23354735
15Parkinsons disease_Homo sapiens_hsa050122.20561885
16Carbon metabolism_Homo sapiens_hsa012002.18247271
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08690128
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06462374
19Oxidative phosphorylation_Homo sapiens_hsa001902.04149557
20Linoleic acid metabolism_Homo sapiens_hsa005911.93398240
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92020902
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.87054755
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86603280
24Pyruvate metabolism_Homo sapiens_hsa006201.82225802
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78802392
26Homologous recombination_Homo sapiens_hsa034401.77097556
27Protein export_Homo sapiens_hsa030601.76340993
28Fanconi anemia pathway_Homo sapiens_hsa034601.74065084
29Alzheimers disease_Homo sapiens_hsa050101.68783147
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.63303867
31Fatty acid biosynthesis_Homo sapiens_hsa000611.60865590
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58281206
33Selenocompound metabolism_Homo sapiens_hsa004501.52878049
34RNA polymerase_Homo sapiens_hsa030201.51648978
35Viral myocarditis_Homo sapiens_hsa054161.47980372
36Insulin resistance_Homo sapiens_hsa049311.46480455
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44584329
38Butanoate metabolism_Homo sapiens_hsa006501.42114736
39Insulin secretion_Homo sapiens_hsa049111.41691635
40Non-homologous end-joining_Homo sapiens_hsa034501.37275171
41Olfactory transduction_Homo sapiens_hsa047401.35348922
42Nicotine addiction_Homo sapiens_hsa050331.34739238
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34430324
44Ether lipid metabolism_Homo sapiens_hsa005651.33119715
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27395750
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27042660
47Huntingtons disease_Homo sapiens_hsa050161.25316971
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.23711274
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.20980139
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20808134
51Fatty acid elongation_Homo sapiens_hsa000621.18355420
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18236562
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16900207
54Circadian entrainment_Homo sapiens_hsa047131.12949570
55Focal adhesion_Homo sapiens_hsa045101.12306989
56ECM-receptor interaction_Homo sapiens_hsa045121.11430747
57AMPK signaling pathway_Homo sapiens_hsa041521.11221159
58Taste transduction_Homo sapiens_hsa047421.09884399
59Basal transcription factors_Homo sapiens_hsa030221.06769956
60Insulin signaling pathway_Homo sapiens_hsa049101.06422430
61Glucagon signaling pathway_Homo sapiens_hsa049221.06394320
62Chemical carcinogenesis_Homo sapiens_hsa052041.06268468
63Arginine biosynthesis_Homo sapiens_hsa002201.05930608
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05796232
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05462449
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03479640
67Regulation of autophagy_Homo sapiens_hsa041401.02830813
68One carbon pool by folate_Homo sapiens_hsa006701.01492076
69RNA degradation_Homo sapiens_hsa030180.99735120
70Retinol metabolism_Homo sapiens_hsa008300.99439074
71Starch and sucrose metabolism_Homo sapiens_hsa005000.95828019
72Histidine metabolism_Homo sapiens_hsa003400.95185969
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94842168
74Caffeine metabolism_Homo sapiens_hsa002320.93690092
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92913798
76Renin secretion_Homo sapiens_hsa049240.90760171
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90570221
78Fat digestion and absorption_Homo sapiens_hsa049750.88420460
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88349132
80beta-Alanine metabolism_Homo sapiens_hsa004100.87692714
81Arachidonic acid metabolism_Homo sapiens_hsa005900.84034442
82Salivary secretion_Homo sapiens_hsa049700.84004000
83Serotonergic synapse_Homo sapiens_hsa047260.83871516
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81897711
85GABAergic synapse_Homo sapiens_hsa047270.81745684
86Mineral absorption_Homo sapiens_hsa049780.81272543
87Glycerolipid metabolism_Homo sapiens_hsa005610.80664932
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79809903
89Morphine addiction_Homo sapiens_hsa050320.77910599
90Purine metabolism_Homo sapiens_hsa002300.77876077
91Tryptophan metabolism_Homo sapiens_hsa003800.77036455
92HIF-1 signaling pathway_Homo sapiens_hsa040660.74689631
93Biosynthesis of amino acids_Homo sapiens_hsa012300.73298437
94Adherens junction_Homo sapiens_hsa045200.71992222
95Metabolic pathways_Homo sapiens_hsa011000.71806907
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.71502839
97Glutamatergic synapse_Homo sapiens_hsa047240.69154957
98Tight junction_Homo sapiens_hsa045300.68195307
99Lysine degradation_Homo sapiens_hsa003100.68017561
100Dorso-ventral axis formation_Homo sapiens_hsa043200.66942177
101Malaria_Homo sapiens_hsa051440.66233943
102Peroxisome_Homo sapiens_hsa041460.65811864
103Oxytocin signaling pathway_Homo sapiens_hsa049210.65366818
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.64020257
105Calcium signaling pathway_Homo sapiens_hsa040200.62356654
106Type II diabetes mellitus_Homo sapiens_hsa049300.61912475
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60860204
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60702724
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58184671
110Amphetamine addiction_Homo sapiens_hsa050310.57642651
111Steroid biosynthesis_Homo sapiens_hsa001000.56414463
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55753650
113Amoebiasis_Homo sapiens_hsa051460.53860249
114Sphingolipid metabolism_Homo sapiens_hsa006000.52612577
115Galactose metabolism_Homo sapiens_hsa000520.52340601
116Bile secretion_Homo sapiens_hsa049760.49021744
117Collecting duct acid secretion_Homo sapiens_hsa049660.46086030
118cAMP signaling pathway_Homo sapiens_hsa040240.45574683
119Arginine and proline metabolism_Homo sapiens_hsa003300.45502768
120Hedgehog signaling pathway_Homo sapiens_hsa043400.45434335
121Dopaminergic synapse_Homo sapiens_hsa047280.45009977
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44967257
123Glutathione metabolism_Homo sapiens_hsa004800.44594633
124Platelet activation_Homo sapiens_hsa046110.43872022
125VEGF signaling pathway_Homo sapiens_hsa043700.43156675
126Gastric acid secretion_Homo sapiens_hsa049710.40797839
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.40367924
128Phenylalanine metabolism_Homo sapiens_hsa003600.39987822
129Circadian rhythm_Homo sapiens_hsa047100.39342893
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38204558
131Folate biosynthesis_Homo sapiens_hsa007900.37950755
132Toxoplasmosis_Homo sapiens_hsa051450.36890850
133Small cell lung cancer_Homo sapiens_hsa052220.35669761
134Proteoglycans in cancer_Homo sapiens_hsa052050.34569221
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34335818
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33899353
137Notch signaling pathway_Homo sapiens_hsa043300.33035041
138Renal cell carcinoma_Homo sapiens_hsa052110.32003006
139Fructose and mannose metabolism_Homo sapiens_hsa000510.30301006
140Ovarian steroidogenesis_Homo sapiens_hsa049130.29843929
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28252284
142Rap1 signaling pathway_Homo sapiens_hsa040150.27960018
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26254860
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25112825
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23696491
146Protein digestion and absorption_Homo sapiens_hsa049740.20547960
147Estrogen signaling pathway_Homo sapiens_hsa049150.20095224
148Nitrogen metabolism_Homo sapiens_hsa009100.18942246
149ABC transporters_Homo sapiens_hsa020100.18596427
150Gap junction_Homo sapiens_hsa045400.18508885
151African trypanosomiasis_Homo sapiens_hsa051430.15890288
152mTOR signaling pathway_Homo sapiens_hsa041500.14016540
153FoxO signaling pathway_Homo sapiens_hsa040680.13995084
154GnRH signaling pathway_Homo sapiens_hsa049120.11955068
155Tyrosine metabolism_Homo sapiens_hsa003500.11379288
156Pancreatic secretion_Homo sapiens_hsa049720.10748458
157Osteoclast differentiation_Homo sapiens_hsa043800.09732377
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.09218398

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »