ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glycine transport (GO:0015816)	7.44512991
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.88460812
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.75477865
4	ATP synthesis coupled proton transport (GO:0015986)	5.75477865
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.74636547
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.59079617
7	NADH dehydrogenase complex assembly (GO:0010257)	5.59079617
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.59079617
9	protein complex biogenesis (GO:0070271)	5.38194449
10	oxidative phosphorylation (GO:0006119)	5.28963099
11	mitochondrial respiratory chain complex assembly (GO:0033108)	5.02175783
12	viral transcription (GO:0019083)	4.99949701
13	respiratory chain complex IV assembly (GO:0008535)	4.79247627
14	translational termination (GO:0006415)	4.72838174
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.68702181
16	GTP biosynthetic process (GO:0006183)	4.55705680
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.51117789
18	protein targeting to ER (GO:0045047)	4.41927688
19	cotranslational protein targeting to membrane (GO:0006613)	4.41780262
20	translational elongation (GO:0006414)	4.41142932
21	respiratory electron transport chain (GO:0022904)	4.36281961
22	electron transport chain (GO:0022900)	4.30429900
23	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.24885575
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.22786794
25	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.19748790
26	UTP biosynthetic process (GO:0006228)	4.18847218
27	protein localization to endoplasmic reticulum (GO:0070972)	4.17478817
28	ATP biosynthetic process (GO:0006754)	4.15152910
29	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.14185862
30	ribosomal small subunit biogenesis (GO:0042274)	4.10127238
31	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.98185850
32	L-phenylalanine catabolic process (GO:0006559)	3.98185850
33	cytochrome complex assembly (GO:0017004)	3.92991977
34	chaperone-mediated protein transport (GO:0072321)	3.92724800
35	protein targeting to mitochondrion (GO:0006626)	3.87443277
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.85193448
37	aldehyde catabolic process (GO:0046185)	3.83427479
38	UTP metabolic process (GO:0046051)	3.83374857
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.82165247
40	viral life cycle (GO:0019058)	3.77583888
41	dicarboxylic acid catabolic process (GO:0043649)	3.77152250
42	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.77070477
43	replicative senescence (GO:0090399)	3.76947053
44	guanosine-containing compound biosynthetic process (GO:1901070)	3.72631482
45	translation (GO:0006412)	3.70124570
46	cellular protein complex disassembly (GO:0043624)	3.59584368
47	peptidyl-arginine omega-N-methylation (GO:0035247)	3.59252286
48	establishment of protein localization to mitochondrion (GO:0072655)	3.55537347
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.54406798
50	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.54406798
51	ribosomal small subunit assembly (GO:0000028)	3.54397496
52	maturation of SSU-rRNA (GO:0030490)	3.53281462
53	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.51205214
54	translational initiation (GO:0006413)	3.49676665
55	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.49616055
56	L-phenylalanine metabolic process (GO:0006558)	3.49352176
57	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.49352176
58	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.48935288
59	pseudouridine synthesis (GO:0001522)	3.48898911
60	protein localization to mitochondrion (GO:0070585)	3.48869824
61	nucleoside triphosphate biosynthetic process (GO:0009142)	3.47819365
62	cellular component biogenesis (GO:0044085)	3.47083657
63	proteasome assembly (GO:0043248)	3.46509441
64	pyrimidine nucleotide catabolic process (GO:0006244)	3.41935415
65	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.38485336
66	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.31936824
67	ribosomal large subunit biogenesis (GO:0042273)	3.29925723
68	histone arginine methylation (GO:0034969)	3.28178787
69	deoxyribonucleotide catabolic process (GO:0009264)	3.27828289
70	cullin deneddylation (GO:0010388)	3.26112007
71	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.23607826
72	ATP hydrolysis coupled proton transport (GO:0015991)	3.23607826
73	hydrogen ion transmembrane transport (GO:1902600)	3.20855596
74	cellular response to zinc ion (GO:0071294)	3.16306834
75	CTP biosynthetic process (GO:0006241)	3.15505322
76	CTP metabolic process (GO:0046036)	3.15505322
77	mitochondrial transport (GO:0006839)	3.15322299
78	regulation of mitochondrial translation (GO:0070129)	3.14947103
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.13708290
80	base-excision repair, AP site formation (GO:0006285)	3.11880325
81	peptidyl-arginine N-methylation (GO:0035246)	3.10088120
82	peptidyl-arginine methylation (GO:0018216)	3.10088120
83	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.09717909
84	protein complex disassembly (GO:0043241)	3.08545088
85	ribonucleoprotein complex biogenesis (GO:0022613)	3.06381711
86	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.05778060
87	regulation of cardioblast proliferation (GO:0003264)	3.05778060
88	deoxyribose phosphate catabolic process (GO:0046386)	3.05712438
89	spliceosomal snRNP assembly (GO:0000387)	3.03906921
90	aerobic respiration (GO:0009060)	3.03138147
91	response to pheromone (GO:0019236)	3.02707052
92	platelet dense granule organization (GO:0060155)	3.01974875
93	protein targeting to membrane (GO:0006612)	3.00797374
94	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.99889035
95	negative regulation of ligase activity (GO:0051352)	2.99889035
96	neurotransmitter uptake (GO:0001504)	2.99239042
97	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.97326343
98	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.97326343
99	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.96674230
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.95994621

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.33244070
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.67730039
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.39968805
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.13358563
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.96305854
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.62818350
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.48675700
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17915660
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.11253218
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.10249257
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.03146750
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82659075
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.70622854
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.69503897
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68574890
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.61449121
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.56147413
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.47540869
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.36651823
20	TTF2_22483619_ChIP-Seq_HELA_Human	2.25676455
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.14598890
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.14448167
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13961772
24	GABP_19822575_ChIP-Seq_HepG2_Human	2.13911658
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.13752875
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09925968
27	VDR_23849224_ChIP-Seq_CD4+_Human	2.09226995
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.08071576
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.91439696
30	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.90554143
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.87435613
32	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.85020725
33	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.82872991
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.77505273
35	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.74750911
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71003294
37	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.66603800
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64870096
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.58709286
40	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.46063784
41	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.45104178
42	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.43253196
43	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.43131747
44	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.42904469
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41996964
46	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.41311414
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.39482331
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35954464
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.34346739
50	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34176551
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.33056263
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29004499
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.28644465
54	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.27350634
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22137864
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.19638871
57	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16707547
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16030099
59	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14555276
60	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.14443403
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13394324
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13012671
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11413177
64	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08813636
65	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.08560906
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07470867
67	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05988334
68	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04778539
69	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04758773
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03735538
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03460469
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.02997377
73	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00403886
74	ERA_21632823_ChIP-Seq_H3396_Human	1.00004329
75	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97920395
76	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.96875544
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95735358
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95587238
79	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95562843
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94880300
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93775190
82	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.91313367
83	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.90001802
84	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.89991292
85	NCOR_22424771_ChIP-Seq_293T_Human	0.89957931
86	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.89715548
87	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.89656390
88	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.88265175
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.87659763
90	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.87257294
91	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.86875616
92	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86793164
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86536609
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.84901043
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.82247762
96	TP53_22573176_ChIP-Seq_HFKS_Human	0.81994380
97	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81814724
98	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.81756498
99	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.81749131
100	TFEB_21752829_ChIP-Seq_HELA_Human	0.81630379

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001188_hyperpigmentation	5.19275061
2	MP0006072_abnormal_retinal_apoptosis	3.31593524
3	MP0006036_abnormal_mitochondrial_physio	3.24956673
4	MP0008007_abnormal_cellular_replicative	3.23471248
5	MP0003195_calcinosis	3.19494391
6	MP0004142_abnormal_muscle_tone	2.88301526
7	MP0003136_yellow_coat_color	2.72075914
8	MP0004147_increased_porphyrin_level	2.57857812
9	MP0003806_abnormal_nucleotide_metabolis	2.50795526
10	MP0005332_abnormal_amino_acid	2.30332525
11	MP0003693_abnormal_embryo_hatching	2.24311443
12	MP0003385_abnormal_body_wall	2.21767564
13	MP0003186_abnormal_redox_activity	2.12675329
14	MP0002234_abnormal_pharynx_morphology	1.99391338
15	MP0002837_dystrophic_cardiac_calcinosis	1.93343852
16	MP0002295_abnormal_pulmonary_circulatio	1.80218601
17	MP0003786_premature_aging	1.70253342
18	MP0000372_irregular_coat_pigmentation	1.66162369
19	MP0008932_abnormal_embryonic_tissue	1.64527193
20	MP0004885_abnormal_endolymph	1.63712626
21	MP0002090_abnormal_vision	1.60719684
22	MP0005253_abnormal_eye_physiology	1.60506945
23	MP0002132_abnormal_respiratory_system	1.56611882
24	MP0002163_abnormal_gland_morphology	1.55545864
25	MP0003077_abnormal_cell_cycle	1.55252408
26	MP0005503_abnormal_tendon_morphology	1.54316242
27	MP0000013_abnormal_adipose_tissue	1.53393634
28	MP0004133_heterotaxia	1.52304055
29	MP0001661_extended_life_span	1.51704298
30	MP0001324_abnormal_eye_pigmentation	1.50104426
31	MP0009046_muscle_twitch	1.46361815
32	MP0000750_abnormal_muscle_regeneration	1.44794361
33	MP0001764_abnormal_homeostasis	1.39635175
34	MP0002254_reproductive_system_inflammat	1.38016235
35	MP0005174_abnormal_tail_pigmentation	1.36766771
36	MP0002938_white_spotting	1.34046514
37	MP0002102_abnormal_ear_morphology	1.33693278
38	MP0002272_abnormal_nervous_system	1.33316622
39	MP0005367_renal/urinary_system_phenotyp	1.28798084
40	MP0000516_abnormal_urinary_system	1.28798084
41	MP0002822_catalepsy	1.28192874
42	MP0005187_abnormal_penis_morphology	1.27707637
43	MP0004145_abnormal_muscle_electrophysio	1.26208717
44	MP0005551_abnormal_eye_electrophysiolog	1.25909747
45	MP0001664_abnormal_digestion	1.25127116
46	MP0003011_delayed_dark_adaptation	1.21917996
47	MP0003123_paternal_imprinting	1.20233593
48	MP0003111_abnormal_nucleus_morphology	1.19050683
49	MP0005266_abnormal_metabolism	1.17017192
50	MP0000678_abnormal_parathyroid_gland	1.14749689
51	MP0008058_abnormal_DNA_repair	1.12907387
52	MP0003718_maternal_effect	1.12093803
53	MP0010234_abnormal_vibrissa_follicle	1.10462627
54	MP0000749_muscle_degeneration	1.08569103
55	MP0002095_abnormal_skin_pigmentation	1.07970540
56	MP0009250_abnormal_appendicular_skeleto	1.07309923
57	MP0002160_abnormal_reproductive_system	1.04569306
58	MP0004957_abnormal_blastocyst_morpholog	1.04237371
59	MP0005670_abnormal_white_adipose	1.03297942
60	MP0005220_abnormal_exocrine_pancreas	1.02984236
61	MP0008789_abnormal_olfactory_epithelium	1.00901112
62	MP0000015_abnormal_ear_pigmentation	1.00093323
63	MP0002734_abnormal_mechanical_nocicepti	0.99603795
64	MP0002653_abnormal_ependyma_morphology	0.96177473
65	MP0001486_abnormal_startle_reflex	0.95705992
66	MP0004043_abnormal_pH_regulation	0.95317181
67	MP0005646_abnormal_pituitary_gland	0.93251207
68	MP0001944_abnormal_pancreas_morphology	0.90767169
69	MP0004858_abnormal_nervous_system	0.88729549
70	MP0000049_abnormal_middle_ear	0.88581190
71	MP0001727_abnormal_embryo_implantation	0.88483510
72	MP0003121_genomic_imprinting	0.87727553
73	MP0006035_abnormal_mitochondrial_morpho	0.87699619
74	MP0000313_abnormal_cell_death	0.86668574
75	MP0009379_abnormal_foot_pigmentation	0.86228338
76	MP0003567_abnormal_fetal_cardiomyocyte	0.85362689
77	MP0010094_abnormal_chromosome_stability	0.85160035
78	MP0005330_cardiomyopathy	0.84820797
79	MP0000470_abnormal_stomach_morphology	0.83856935
80	MP0005636_abnormal_mineral_homeostasis	0.82342144
81	MP0005409_darkened_coat_color	0.81642671
82	MP0003942_abnormal_urinary_system	0.80277846
83	MP0005623_abnormal_meninges_morphology	0.80226957
84	MP0008875_abnormal_xenobiotic_pharmacok	0.80120211
85	MP0009053_abnormal_anal_canal	0.78911713
86	MP0002177_abnormal_outer_ear	0.77945367
87	MP0009745_abnormal_behavioral_response	0.77785191
88	MP0002751_abnormal_autonomic_nervous	0.76299696
89	MP0003646_muscle_fatigue	0.74871487
90	MP0000639_abnormal_adrenal_gland	0.74767321
91	MP0003137_abnormal_impulse_conducting	0.73539453
92	MP0005645_abnormal_hypothalamus_physiol	0.73414930
93	MP0003936_abnormal_reproductive_system	0.72796384
94	MP0001765_abnormal_ion_homeostasis	0.72676813
95	MP0000955_abnormal_spinal_cord	0.72364079
96	MP0001968_abnormal_touch/_nociception	0.71794353
97	MP0003283_abnormal_digestive_organ	0.71348218
98	MP0001881_abnormal_mammary_gland	0.70855392
99	MP0010368_abnormal_lymphatic_system	0.68418227
100	MP0001730_embryonic_growth_arrest	0.68255042

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal Fanconi syndrome (HP:0001994)	5.04052907
2	Acute necrotizing encephalopathy (HP:0006965)	4.92911713
3	Mitochondrial inheritance (HP:0001427)	4.86091935
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.54330558
5	Acute encephalopathy (HP:0006846)	4.52351685
6	Increased CSF lactate (HP:0002490)	4.20111061
7	Hepatocellular necrosis (HP:0001404)	4.16481258
8	Progressive macrocephaly (HP:0004481)	4.09645608
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.85070340
10	Congenital malformation of the right heart (HP:0011723)	3.79118107
11	Double outlet right ventricle (HP:0001719)	3.79118107
12	Hepatic necrosis (HP:0002605)	3.75621269
13	CNS hypomyelination (HP:0003429)	3.72279844
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.72130799
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.62381283
16	Cerebral edema (HP:0002181)	3.60677806
17	Increased hepatocellular lipid droplets (HP:0006565)	3.59145555
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54772717
19	Abnormality of magnesium homeostasis (HP:0004921)	3.45369997
20	Abnormal number of erythroid precursors (HP:0012131)	3.43452078
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.38618784
22	Lipid accumulation in hepatocytes (HP:0006561)	3.24802749
23	Neoplasm of the adrenal cortex (HP:0100641)	3.17225917
24	Lactic acidosis (HP:0003128)	3.11429939
25	Increased intramyocellular lipid droplets (HP:0012240)	3.09699484
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.02439289
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.02439289
28	Abnormality of renal resorption (HP:0011038)	3.01220798
29	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.01200203
30	3-Methylglutaconic aciduria (HP:0003535)	2.91244630
31	Respiratory failure (HP:0002878)	2.86166749
32	Macrocytic anemia (HP:0001972)	2.84821275
33	Exertional dyspnea (HP:0002875)	2.74302476
34	Concave nail (HP:0001598)	2.70197446
35	Increased serum lactate (HP:0002151)	2.68731308
36	Generalized aminoaciduria (HP:0002909)	2.67938306
37	Increased muscle lipid content (HP:0009058)	2.65346079
38	Truncus arteriosus (HP:0001660)	2.63235622
39	Hypomagnesemia (HP:0002917)	2.62097195
40	Unilateral renal agenesis (HP:0000122)	2.56884414
41	Hyperammonemia (HP:0001987)	2.52921166
42	Exercise intolerance (HP:0003546)	2.51464804
43	Pancreatic islet-cell hyperplasia (HP:0004510)	2.49189058
44	Reticulocytopenia (HP:0001896)	2.47845658
45	True hermaphroditism (HP:0010459)	2.47381483
46	Lethargy (HP:0001254)	2.38356948
47	Neoplasm of the adrenal gland (HP:0100631)	2.37651559
48	Pancreatic fibrosis (HP:0100732)	2.36291686
49	Increased circulating renin level (HP:0000848)	2.30073026
50	Sclerocornea (HP:0000647)	2.29543186
51	Nephrogenic diabetes insipidus (HP:0009806)	2.28689722
52	Respiratory difficulties (HP:0002880)	2.27183621
53	Congenital stationary night blindness (HP:0007642)	2.26675806
54	Hypokinesia (HP:0002375)	2.22625866
55	Type I transferrin isoform profile (HP:0003642)	2.20064705
56	Hypoplastic left heart (HP:0004383)	2.19326305
57	Congenital primary aphakia (HP:0007707)	2.19241824
58	Arthropathy (HP:0003040)	2.18285322
59	Gait imbalance (HP:0002141)	2.15494508
60	Tetany (HP:0001281)	2.14730139
61	Paralysis (HP:0003470)	2.14547729
62	Severe global developmental delay (HP:0011344)	2.12657730
63	Pancreatic cysts (HP:0001737)	2.11809348
64	Optic disc pallor (HP:0000543)	2.09962983
65	Prolonged neonatal jaundice (HP:0006579)	2.08969069
66	Leukodystrophy (HP:0002415)	2.08885285
67	Hyperglycinemia (HP:0002154)	2.08851375
68	Occipital encephalocele (HP:0002085)	2.08687671
69	Hepatocellular carcinoma (HP:0001402)	2.08065982
70	Abnormal protein glycosylation (HP:0012346)	2.06263650
71	Abnormal glycosylation (HP:0012345)	2.06263650
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06263650
73	Abnormal protein N-linked glycosylation (HP:0012347)	2.06263650
74	Glycosuria (HP:0003076)	2.05664853
75	Abnormality of urine glucose concentration (HP:0011016)	2.05664853
76	Hyperphosphaturia (HP:0003109)	2.05634229
77	Type II lissencephaly (HP:0007260)	2.03043491
78	Pigmentary retinal degeneration (HP:0001146)	2.01960801
79	Ileus (HP:0002595)	2.01128623
80	Wrist flexion contracture (HP:0001239)	2.01059170
81	Medial flaring of the eyebrow (HP:0010747)	2.00647139
82	Death in infancy (HP:0001522)	1.98114622
83	Hyperthyroidism (HP:0000836)	1.97030859
84	Muscle stiffness (HP:0003552)	1.95796495
85	Abnormality of the pulmonary veins (HP:0011718)	1.94158964
86	X-linked dominant inheritance (HP:0001423)	1.93145273
87	Left ventricular hypertrophy (HP:0001712)	1.90675808
88	Emotional lability (HP:0000712)	1.88691584
89	Prostate neoplasm (HP:0100787)	1.88523082
90	Flat capital femoral epiphysis (HP:0003370)	1.86274344
91	Transposition of the great arteries (HP:0001669)	1.85050517
92	Abnormal connection of the cardiac segments (HP:0011545)	1.85050517
93	Abnormal ventriculo-arterial connection (HP:0011563)	1.85050517
94	Large for gestational age (HP:0001520)	1.84529588
95	Microretrognathia (HP:0000308)	1.84266398
96	Nausea (HP:0002018)	1.83664622
97	Attenuation of retinal blood vessels (HP:0007843)	1.83619815
98	Squamous cell carcinoma (HP:0002860)	1.81398078
99	Intestinal atresia (HP:0011100)	1.81354256
100	Melanoma (HP:0002861)	1.81337238

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	7.47196653
2	TAF1	4.29305065
3	ZAK	3.82195991
4	SMG1	3.58069689
5	BUB1	3.24404959
6	BCKDK	3.11149814
7	NME2	3.10277856
8	ARAF	2.63214444
9	WNK4	2.62841779
10	STK16	2.33512491
11	CSNK1G3	2.19337523
12	NUAK1	2.15749739
13	BRAF	2.04033605
14	CSNK1A1L	2.01837429
15	CSNK1G1	1.99651182
16	VRK1	1.90304560
17	NME1	1.82506032
18	CSNK1G2	1.80489185
19	DYRK2	1.76934979
20	MAP4K2	1.41272120
21	PRKD3	1.41234714
22	MAP3K9	1.38980135
23	CAMK1D	1.33161265
24	TNIK	1.29653083
25	PLK3	1.26448881
26	TTK	1.25611674
27	MAP3K11	1.25425751
28	CDK19	1.22668897
29	DAPK1	1.15933762
30	MAP3K12	1.15831115
31	DYRK1A	1.12856323
32	AKT3	1.07573949
33	CHEK2	1.02506142
34	ABL2	1.01391593
35	MAPKAPK5	1.01054539
36	MAP3K4	0.94046452
37	HIPK2	0.90690871
38	MATK	0.87985622
39	CAMK1G	0.86677240
40	ADRBK2	0.82983504
41	STK39	0.82464521
42	CAMK1	0.81430790
43	MAP2K2	0.78303252
44	GRK5	0.76748862
45	LIMK1	0.75161584
46	GRK1	0.69394370
47	AURKA	0.68598513
48	CAMKK2	0.67696022
49	KIT	0.67134573
50	ATR	0.66088373
51	MAP3K13	0.65411272
52	MAP3K8	0.65399705
53	MOS	0.62430791
54	MINK1	0.61586027
55	WNK3	0.59315899
56	PHKG1	0.55407106
57	PHKG2	0.55407106
58	TESK2	0.55136878
59	CSNK2A2	0.53803954
60	DYRK3	0.53547110
61	CSNK1A1	0.53366610
62	MAP2K4	0.51160179
63	PRKCG	0.50595487
64	PAK1	0.49606040
65	STK4	0.49413418
66	IRAK3	0.49174977
67	PBK	0.48601035
68	EIF2AK1	0.44930830
69	PRKCI	0.44834829
70	TLK1	0.44034899
71	MAP2K7	0.43867564
72	NEK2	0.42886445
73	PRKG2	0.37902129
74	AURKB	0.37657535
75	DAPK3	0.36779008
76	CSNK2A1	0.36598308
77	RPS6KA4	0.34575715
78	PLK4	0.33190311
79	PASK	0.32397430
80	PLK1	0.32374263
81	EPHA3	0.32370157
82	STK11	0.32105282
83	ILK	0.32096353
84	SRPK1	0.32018130
85	ALK	0.31956164
86	AKT2	0.31649330
87	CAMK2G	0.31431433
88	RPS6KA5	0.31364845
89	BRSK2	0.31314426
90	CAMKK1	0.28907015
91	CDK11A	0.27452471
92	CAMK2D	0.26150775
93	OXSR1	0.25982856
94	MUSK	0.24940448
95	CSNK1E	0.24218394
96	BRSK1	0.24053144
97	PIM2	0.22316496
98	CDK15	0.21253122
99	OBSCN	0.20056895
100	WEE1	0.18999154

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.82651205
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.44915070
3	Proteasome_Homo sapiens_hsa03050	3.89522573
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.63875828
5	Parkinsons disease_Homo sapiens_hsa05012	3.62269727
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.72120764
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.70343309
8	Huntingtons disease_Homo sapiens_hsa05016	2.61974014
9	Alzheimers disease_Homo sapiens_hsa05010	2.51984974
10	Sulfur relay system_Homo sapiens_hsa04122	2.50500211
11	Protein export_Homo sapiens_hsa03060	2.16276051
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.05347289
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.95168797
14	Sulfur metabolism_Homo sapiens_hsa00920	1.93666828
15	Glutathione metabolism_Homo sapiens_hsa00480	1.91587309
16	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.86519904
17	One carbon pool by folate_Homo sapiens_hsa00670	1.78357803
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.76460130
19	DNA replication_Homo sapiens_hsa03030	1.75426056
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.67093943
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62392493
22	Mismatch repair_Homo sapiens_hsa03430	1.61124380
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49121189
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.47746317
25	RNA polymerase_Homo sapiens_hsa03020	1.47711388
26	Fatty acid elongation_Homo sapiens_hsa00062	1.46657931
27	Folate biosynthesis_Homo sapiens_hsa00790	1.45896324
28	Base excision repair_Homo sapiens_hsa03410	1.43175980
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32918685
30	Homologous recombination_Homo sapiens_hsa03440	1.25292218
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20827157
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.20777530
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14904153
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.14288462
35	Propanoate metabolism_Homo sapiens_hsa00640	1.10015681
36	p53 signaling pathway_Homo sapiens_hsa04115	1.09673647
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08511586
38	Purine metabolism_Homo sapiens_hsa00230	1.07342439
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04276849
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03151111
41	Metabolic pathways_Homo sapiens_hsa01100	1.01020559
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00725431
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99311988
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98895134
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98497802
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98178518
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.97453052
48	RNA transport_Homo sapiens_hsa03013	0.80593395
49	Spliceosome_Homo sapiens_hsa03040	0.80353007
50	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76385248
51	Peroxisome_Homo sapiens_hsa04146	0.73704301
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.72900942
53	Pentose phosphate pathway_Homo sapiens_hsa00030	0.71798993
54	GABAergic synapse_Homo sapiens_hsa04727	0.70651553
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66086257
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62464002
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59311977
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.59233275
59	Regulation of autophagy_Homo sapiens_hsa04140	0.57397911
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55009037
61	Basal transcription factors_Homo sapiens_hsa03022	0.53494102
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53434776
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52598553
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51930848
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51065408
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.50792279
67	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50779068
68	RNA degradation_Homo sapiens_hsa03018	0.50393445
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49989346
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49399074
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49264867
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49022381
73	Carbon metabolism_Homo sapiens_hsa01200	0.47732105
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.46714773
75	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46223949
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46010584
77	Butanoate metabolism_Homo sapiens_hsa00650	0.43839934
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42405865
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41834113
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40117679
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.38988721
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36070984
83	Fatty acid degradation_Homo sapiens_hsa00071	0.35907868
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35602600
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.35596798
86	Cell cycle_Homo sapiens_hsa04110	0.33733875
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.31550326
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30494604
89	Nicotine addiction_Homo sapiens_hsa05033	0.29281056
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.25306121
91	Histidine metabolism_Homo sapiens_hsa00340	0.23698241
92	Mineral absorption_Homo sapiens_hsa04978	0.21481322
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20613460
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.19380788
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.18293882
96	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.16434594
97	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.15327861
98	Caffeine metabolism_Homo sapiens_hsa00232	0.09787718
99	Phototransduction_Homo sapiens_hsa04744	0.09270705
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.07585040

C1QTNF9B-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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