C1orf74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.24785898
2desmosome organization (GO:0002934)4.67147194
3maturation of 5.8S rRNA (GO:0000460)4.59847529
4keratinocyte proliferation (GO:0043616)4.40392100
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32119962
6negative regulation of cell killing (GO:0031342)3.90132380
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90132380
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84871470
9antigen processing and presentation via MHC class Ib (GO:0002475)3.59874429
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58350603
11antigen processing and presentation of endogenous antigen (GO:0019883)3.56276831
12regulation of B cell receptor signaling pathway (GO:0050855)3.40329878
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.40095844
14positive regulation of gamma-delta T cell activation (GO:0046645)3.33825172
15establishment of skin barrier (GO:0061436)3.17709012
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16476898
17negative regulation of T cell mediated immunity (GO:0002710)3.06476154
18cell-substrate junction assembly (GO:0007044)2.97166951
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96776967
20positive regulation of keratinocyte differentiation (GO:0045618)2.92572117
21regulation of water loss via skin (GO:0033561)2.91235130
22regulation of isotype switching to IgG isotypes (GO:0048302)2.89085093
23positive regulation of epidermal cell differentiation (GO:0045606)2.86807095
24hair cycle (GO:0042633)2.86687315
25molting cycle (GO:0042303)2.86687315
26keratinocyte development (GO:0003334)2.83636958
27cellular response to interleukin-15 (GO:0071350)2.83415155
28T-helper 1 type immune response (GO:0042088)2.80530791
29positive regulation of epidermis development (GO:0045684)2.80379319
30positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73672988
31tolerance induction (GO:0002507)2.71785070
32response to interleukin-15 (GO:0070672)2.69532514
33regulation of alpha-beta T cell proliferation (GO:0046640)2.67881287
34type I interferon signaling pathway (GO:0060337)2.66257474
35cellular response to type I interferon (GO:0071357)2.66257474
36positive regulation of B cell differentiation (GO:0045579)2.65770516
37negative T cell selection (GO:0043383)2.64675960
38DNA deamination (GO:0045006)2.63650352
39response to type I interferon (GO:0034340)2.63204110
40regulation of hair follicle development (GO:0051797)2.61400182
41positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61385388
42nuclear pore complex assembly (GO:0051292)2.61295155
43regulation of hypersensitivity (GO:0002883)2.60784705
44negative thymic T cell selection (GO:0045060)2.58207755
45positive regulation of hair follicle development (GO:0051798)2.56285170
46positive regulation of hair cycle (GO:0042635)2.56285170
47rRNA methylation (GO:0031167)2.53542392
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53106627
49leukocyte aggregation (GO:0070486)2.52461514
50positive regulation of isotype switching (GO:0045830)2.52361834
51regulation of gamma-delta T cell differentiation (GO:0045586)2.52022247
52macrophage activation involved in immune response (GO:0002281)2.51861512
53regulation of interferon-beta biosynthetic process (GO:0045357)2.50773581
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.49975839
55immunoglobulin mediated immune response (GO:0016064)2.49827052
56regulation of translational termination (GO:0006449)2.48282813
57negative regulation of keratinocyte proliferation (GO:0010839)2.47378140
58modulation by symbiont of host immune response (GO:0052553)2.46585841
59positive regulation by symbiont of host defense response (GO:0052509)2.46585841
60modulation by symbiont of host defense response (GO:0052031)2.46585841
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46585841
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46585841
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.46585841
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45571015
65activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.45268597
66B cell mediated immunity (GO:0019724)2.43955990
67ribosome assembly (GO:0042255)2.43440309
68regulation of T cell mediated cytotoxicity (GO:0001914)2.42787597
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.42026648
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41588799
71regulation of gamma-delta T cell activation (GO:0046643)2.41462359
72interferon-gamma secretion (GO:0072643)2.39844813
73keratinization (GO:0031424)2.39475549
74negative regulation of B cell proliferation (GO:0030889)2.39024290
75negative regulation of protein oligomerization (GO:0032460)2.34819267
76detection of bacterium (GO:0016045)2.34225178
77regulation of regulatory T cell differentiation (GO:0045589)2.33936797
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33378502
79pore complex assembly (GO:0046931)2.32517843
80nucleotide transmembrane transport (GO:1901679)2.31965088
81necroptotic process (GO:0070266)2.31529405
82neutrophil activation involved in immune response (GO:0002283)2.31214430
83detection of other organism (GO:0098543)2.28874907
84regulation of T cell receptor signaling pathway (GO:0050856)2.28194895
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.28033634
86positive regulation of T cell mediated immunity (GO:0002711)2.27396792
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.26105312
88rRNA modification (GO:0000154)2.26092828
89regulation of T cell mediated immunity (GO:0002709)2.24293588
90regulation of B cell differentiation (GO:0045577)2.24236246
91negative regulation of execution phase of apoptosis (GO:1900118)2.23797137
92DNA catabolic process, exonucleolytic (GO:0000738)2.23020352
93interferon-gamma-mediated signaling pathway (GO:0060333)2.21073574
94positive regulation of interferon-beta production (GO:0032728)2.18521228
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.18296773
96negative regulation of ligase activity (GO:0051352)2.18296773
97nuclear pore organization (GO:0006999)2.16659369
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.15921121
99thymic T cell selection (GO:0045061)2.15632531
100negative regulation of leukocyte mediated immunity (GO:0002704)2.14525392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.94171987
2E2F7_22180533_ChIP-Seq_HELA_Human4.46822817
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93334888
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.77969827
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.66637250
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57851530
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53343947
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.33267860
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32429356
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30440742
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30204127
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29694790
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12350160
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.11063090
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02462489
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01709573
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94821084
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94742602
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92664410
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.89363205
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85653093
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.82926172
23VDR_23849224_ChIP-Seq_CD4+_Human1.78225928
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77590234
25MYB_26560356_Chip-Seq_TH2_Human1.76888387
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73765042
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72680699
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.72269550
29* SPI1_23547873_ChIP-Seq_NB4_Human1.67489828
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66985932
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65846687
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65846687
33DCP1A_22483619_ChIP-Seq_HELA_Human1.65702574
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63109048
35FOXP3_21729870_ChIP-Seq_TREG_Human1.62383011
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62218360
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60247168
38MYB_26560356_Chip-Seq_TH1_Human1.58904813
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58511006
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57594060
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56103643
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.54837520
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54522292
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.51576175
45* MAF_26560356_Chip-Seq_TH1_Human1.51288841
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47994695
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47059978
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45648612
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44576018
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43979279
51* ELK1_19687146_ChIP-ChIP_HELA_Human1.43053793
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39347638
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38182535
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37871952
55MYC_22102868_ChIP-Seq_BL_Human1.32340062
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29513648
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29372201
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28454824
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27195528
60CIITA_25753668_ChIP-Seq_RAJI_Human1.25652643
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24155957
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22655803
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22511316
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20295980
65FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20184377
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20156643
67TFEB_21752829_ChIP-Seq_HELA_Human1.19958646
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19858257
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18416800
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17423701
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17362628
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16923524
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14343488
74MAF_26560356_Chip-Seq_TH2_Human1.13507434
75UTX_26944678_Chip-Seq_JUKART_Human1.13009039
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11329636
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.10475837
78KDM5A_27292631_Chip-Seq_BREAST_Human1.08520025
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.08414605
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06981455
81* GABP_19822575_ChIP-Seq_HepG2_Human1.06887581
82* XRN2_22483619_ChIP-Seq_HELA_Human1.04204308
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02509884
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02375178
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.01400097
86* GATA3_26560356_Chip-Seq_TH2_Human1.01016921
87IRF8_27001747_Chip-Seq_BMDM_Mouse0.98888723
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.97808332
89RUNX_20019798_ChIP-Seq_JUKART_Human0.97789632
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95059188
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93898169
92RUNX1_22412390_ChIP-Seq_EML_Mouse0.93831311
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93661806
94* ATF3_27146783_Chip-Seq_COLON_Human0.93160918
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92955689
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92558174
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92277305
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92256736
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92152389
100VDR_24763502_ChIP-Seq_THP-1_Human0.91837396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.84179721
2MP0003941_abnormal_skin_development3.23445507
3MP0010234_abnormal_vibrissa_follicle2.90158074
4MP0003763_abnormal_thymus_physiology2.82144745
5MP0004381_abnormal_hair_follicle2.78563293
6MP0003693_abnormal_embryo_hatching2.62503603
7MP0001216_abnormal_epidermal_layer2.39704876
8MP0002796_impaired_skin_barrier2.32534375
9MP0005671_abnormal_response_to2.30846069
10MP0006082_CNS_inflammation2.25120655
11MP0002166_altered_tumor_susceptibility2.19220063
12MP0008260_abnormal_autophagy2.14919296
13MP0002254_reproductive_system_inflammat2.12059911
14MP0001835_abnormal_antigen_presentation2.03649904
15MP0003453_abnormal_keratinocyte_physiol2.02382622
16MP0003300_gastrointestinal_ulcer1.98103680
17MP0001800_abnormal_humoral_immune1.93899824
18MP0002006_tumorigenesis1.92512848
19MP0009333_abnormal_splenocyte_physiolog1.88615688
20MP0002060_abnormal_skin_morphology1.87704005
21MP0009785_altered_susceptibility_to1.85067674
22MP0005000_abnormal_immune_tolerance1.82009164
23MP0000685_abnormal_immune_system1.81726459
24MP0004947_skin_inflammation1.78902132
25MP0004957_abnormal_blastocyst_morpholog1.78048249
26MP0010094_abnormal_chromosome_stability1.77344974
27MP0010678_abnormal_skin_adnexa1.72071363
28MP0000467_abnormal_esophagus_morphology1.70134397
29MP0002396_abnormal_hematopoietic_system1.69635877
30MP0002452_abnormal_antigen_presenting1.68857118
31MP0002723_abnormal_immune_serum1.68612840
32MP0003436_decreased_susceptibility_to1.65783005
33MP0002420_abnormal_adaptive_immunity1.63919562
34MP0001819_abnormal_immune_cell1.63429780
35MP0005501_abnormal_skin_physiology1.63317659
36MP0003786_premature_aging1.57813920
37MP0000762_abnormal_tongue_morphology1.57477731
38MP0001873_stomach_inflammation1.55248299
39MP0005025_abnormal_response_to1.52628111
40MP0001790_abnormal_immune_system1.50208960
41MP0005387_immune_system_phenotype1.50208960
42MP0003806_abnormal_nucleotide_metabolis1.48365562
43MP0004264_abnormal_extraembryonic_tissu1.47107794
44MP0003566_abnormal_cell_adhesion1.46027722
45MP0002398_abnormal_bone_marrow1.46007999
46MP0005451_abnormal_body_composition1.43994796
47MP0000377_abnormal_hair_follicle1.42237573
48MP0010155_abnormal_intestine_physiology1.41402638
49MP0000858_altered_metastatic_potential1.40401222
50MP0000703_abnormal_thymus_morphology1.38269288
51MP0002419_abnormal_innate_immunity1.38149644
52MP0003191_abnormal_cellular_cholesterol1.37241282
53MP0008058_abnormal_DNA_repair1.37211456
54MP0000716_abnormal_immune_system1.36490127
55MP0002098_abnormal_vibrissa_morphology1.32967617
56MP0005075_abnormal_melanosome_morpholog1.31890922
57MP0003111_abnormal_nucleus_morphology1.31439889
58MP0000383_abnormal_hair_follicle1.30150973
59MP0002009_preneoplasia1.28777716
60MP0000427_abnormal_hair_cycle1.25780739
61MP0002722_abnormal_immune_system1.25777361
62MP0003724_increased_susceptibility_to1.25676887
63MP0002148_abnormal_hypersensitivity_rea1.24430568
64MP0001849_ear_inflammation1.24389451
65MP0000689_abnormal_spleen_morphology1.20179172
66MP0002405_respiratory_system_inflammati1.17671013
67MP0002429_abnormal_blood_cell1.16042813
68MP0010771_integument_phenotype1.15480780
69MP0005023_abnormal_wound_healing1.13683800
70MP0008007_abnormal_cellular_replicative1.12702275
71MP0002234_abnormal_pharynx_morphology1.12220853
72MP0001845_abnormal_inflammatory_respons1.11050649
73MP0001851_eye_inflammation1.10818055
74MP0010352_gastrointestinal_tract_polyps1.09989831
75MP0002019_abnormal_tumor_incidence1.09856828
76MP0003077_abnormal_cell_cycle1.07399413
77MP0003183_abnormal_peptide_metabolism1.06209226
78MP0009931_abnormal_skin_appearance1.04167447
79MP0000465_gastrointestinal_hemorrhage1.02542297
80MP0001191_abnormal_skin_condition1.00446342
81MP0003315_abnormal_perineum_morphology0.97703113
82MP0000490_abnormal_crypts_of0.97393895
83MP0000678_abnormal_parathyroid_gland0.96474420
84MP0003866_abnormal_defecation0.96176609
85MP0008932_abnormal_embryonic_tissue0.95999677
86MP0001919_abnormal_reproductive_system0.95266934
87MP0005310_abnormal_salivary_gland0.92900256
88MP0002132_abnormal_respiratory_system0.92079494
89MP0002277_abnormal_respiratory_mucosa0.91257096
90MP0001348_abnormal_lacrimal_gland0.88354521
91MP0008877_abnormal_DNA_methylation0.87129481
92MP0003718_maternal_effect0.86908586
93MP0003448_altered_tumor_morphology0.85531626
94MP0000367_abnormal_coat/_hair0.83291287
95MP0008469_abnormal_protein_level0.82779944
96MP0005083_abnormal_biliary_tract0.81758468
97MP0006035_abnormal_mitochondrial_morpho0.81427690
98MP0000350_abnormal_cell_proliferation0.81292825
99MP0005275_abnormal_skin_tensile0.79654305
100MP0005464_abnormal_platelet_physiology0.78611364

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.17419232
2Milia (HP:0001056)7.02921891
3Fragile nails (HP:0001808)6.57642666
4Abnormality of nail color (HP:0100643)6.51538218
5Plantar hyperkeratosis (HP:0007556)6.44867127
6Thick nail (HP:0001805)4.77272121
7Oral leukoplakia (HP:0002745)4.71505354
8Alopecia of scalp (HP:0002293)4.59743752
9Palmoplantar hyperkeratosis (HP:0000972)4.57062653
10Palmar hyperkeratosis (HP:0010765)4.36623640
11Amniotic constriction ring (HP:0009775)4.20524705
12Abnormality of placental membranes (HP:0011409)4.20524705
13Nail dystrophy (HP:0008404)4.04759949
14Atrophic scars (HP:0001075)3.99366966
15Ridged nail (HP:0001807)3.86927125
16Abnormal blistering of the skin (HP:0008066)3.62802969
17Pustule (HP:0200039)3.54206233
18Recurrent bacterial skin infections (HP:0005406)3.28530573
19Sparse eyelashes (HP:0000653)3.02563258
20Pili torti (HP:0003777)3.01436711
21Sparse scalp hair (HP:0002209)2.96572311
22Lip pit (HP:0100267)2.93245620
23Dry hair (HP:0011359)2.91521153
24Popliteal pterygium (HP:0009756)2.91470045
25Hypoplasia of dental enamel (HP:0006297)2.82288845
26Recurrent cutaneous fungal infections (HP:0011370)2.81461918
27Chronic mucocutaneous candidiasis (HP:0002728)2.81461918
28Cheilitis (HP:0100825)2.80080798
29Autoimmune hemolytic anemia (HP:0001890)2.78380738
30Recurrent fungal infections (HP:0002841)2.65824046
31Abnormality of T cell physiology (HP:0011840)2.62893271
32T lymphocytopenia (HP:0005403)2.61967804
33Ankyloglossia (HP:0010296)2.61400495
34Increased IgE level (HP:0003212)2.59707248
35Right ventricular cardiomyopathy (HP:0011663)2.59609004
36Abnormality of T cells (HP:0002843)2.59160181
37Abnormality of T cell number (HP:0011839)2.57444146
38Increased IgM level (HP:0003496)2.54589685
39Skin ulcer (HP:0200042)2.53820940
40Recurrent skin infections (HP:0001581)2.50802668
41Abnormal hair laboratory examination (HP:0003328)2.48508369
42Recurrent viral infections (HP:0004429)2.47808768
43Recurrent abscess formation (HP:0002722)2.39646227
44Urticaria (HP:0001025)2.37802884
45Selective tooth agenesis (HP:0001592)2.36641470
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.35027375
47Aplasia cutis congenita (HP:0001057)2.33526610
48Premature loss of primary teeth (HP:0006323)2.32001178
49Parakeratosis (HP:0001036)2.30444003
50IgG deficiency (HP:0004315)2.26905051
51Hyperhidrosis (HP:0000975)2.25674054
52Stomatitis (HP:0010280)2.25209607
53Abnormality of oral frenula (HP:0000190)2.22796945
54Aplastic anemia (HP:0001915)2.22792992
55Squamous cell carcinoma (HP:0002860)2.20721972
56Woolly hair (HP:0002224)2.20662648
57Abnormality of the preputium (HP:0100587)2.18522554
58Poikiloderma (HP:0001029)2.16052418
59Hypotrichosis (HP:0001006)2.14982301
60Pterygium (HP:0001059)2.12324185
61Panhypogammaglobulinemia (HP:0003139)2.12291562
62Congenital ichthyosiform erythroderma (HP:0007431)2.08208343
63Carious teeth (HP:0000670)2.06985040
64Inflammation of the large intestine (HP:0002037)2.05003423
65Eczematoid dermatitis (HP:0000976)2.02400606
66Abnormality of the salivary glands (HP:0010286)2.01565720
67Chronic diarrhea (HP:0002028)2.01301497
68Hypoplastic labia majora (HP:0000059)1.99790131
69IgM deficiency (HP:0002850)1.99685115
70Anonychia (HP:0001798)1.97854014
71Death in infancy (HP:0001522)1.97745210
72Gastrointestinal inflammation (HP:0004386)1.95668365
73Periodontitis (HP:0000704)1.94901826
74Lymphoma (HP:0002665)1.91809640
75Abnormality of macrophages (HP:0004311)1.89261288
76Abnormality of the fingernails (HP:0001231)1.89155512
77Erythema (HP:0010783)1.87967905
78Severe combined immunodeficiency (HP:0004430)1.87195209
79Elevated erythrocyte sedimentation rate (HP:0003565)1.87127891
80Keratoconjunctivitis (HP:0001096)1.86124624
81Ectropion (HP:0000656)1.84373293
82Combined immunodeficiency (HP:0005387)1.80243608
83Abnormality of the labia majora (HP:0012881)1.79390040
84Skin rash (HP:0000988)1.79311806
85Lymphopenia (HP:0001888)1.78451599
86Abnormality of the axillary hair (HP:0100134)1.77848916
87Abnormality of secondary sexual hair (HP:0009888)1.77848916
88Flat occiput (HP:0005469)1.76555341
89Multifactorial inheritance (HP:0001426)1.75118281
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.73546949
91Palmoplantar keratoderma (HP:0000982)1.73401763
92Verrucae (HP:0200043)1.72276041
93Papilloma (HP:0012740)1.72276041
94IgA deficiency (HP:0002720)1.72169330
95Agammaglobulinemia (HP:0004432)1.69317731
96Abnormality of the neuromuscular junction (HP:0003398)1.66454860
97Fatigable weakness (HP:0003473)1.66454860
98Chromsome breakage (HP:0040012)1.66402037
99Abnormality of B cell number (HP:0010975)1.65812072
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64959538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.43213832
2BUB12.88161705
3MAP3K132.82181715
4MAP3K22.60139567
5PASK2.48364131
6FGR2.38866924
7EIF2AK12.37223071
8STK242.27155537
9TLK12.14958120
10MAP3K142.05139552
11STK102.01140025
12MAP4K11.99988108
13MST1R1.99614487
14ZAK1.98216696
15MET1.97094745
16ITK1.84643147
17GRK61.78288376
18JAK31.68469917
19EIF2AK31.58008207
20PIM21.54694731
21CSK1.52632017
22MAP3K31.45598065
23NUAK11.45269166
24ARAF1.44662256
25BLK1.40079790
26CSF1R1.37195458
27JAK11.34800598
28SMG11.34111976
29TYK21.32735948
30TXK1.32143754
31IRAK41.31502362
32TESK21.30496114
33IKBKB1.26340926
34NME21.26248554
35FES1.22157517
36TAF11.19924870
37LATS11.16577835
38NLK1.16437167
39RIPK41.14723426
40BRSK21.14242181
41TGFBR21.11748771
42BTK1.10074613
43TTK1.08860049
44SCYL21.08244959
45PAK41.06720875
46ERN11.02362816
47SRPK10.99774806
48EPHA20.96264918
49SYK0.94973748
50EPHB10.94576211
51PBK0.94057573
52RAF10.91909203
53STK160.89582696
54EIF2AK20.88475896
55IKBKE0.88440088
56PIM10.88298428
57MAP3K90.88273372
58ZAP700.86631581
59TSSK60.86195948
60NME10.84056865
61BMPR20.81770982
62CDK40.78586890
63TBK10.78355867
64LYN0.78013298
65STK30.77211911
66PLK40.76777251
67HCK0.76747165
68STK38L0.75133877
69VRK20.73205338
70TRIM280.72242795
71KSR20.70751695
72RPS6KB20.67337049
73LCK0.67238558
74VRK10.67220726
75TAOK30.67097237
76BRD40.66328712
77TEC0.64068590
78MAP3K10.63987853
79MAP3K80.60648536
80FLT30.59588287
81NEK90.59501446
82PTK2B0.59395289
83JAK20.55863031
84SIK30.55794132
85MAP2K30.55750531
86CDC70.55517185
87MAP3K100.53788817
88MAP3K120.53690619
89CDK60.48401260
90RPS6KA40.47927814
91TRPM70.47759157
92PLK10.47475136
93PRKCI0.47215984
94GRK70.43232247
95ERBB30.41897770
96BRAF0.41703883
97TNK20.39839967
98BRSK10.38471522
99MAP2K20.36396590
100AURKA0.35926133

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.25382158
2Proteasome_Homo sapiens_hsa030503.19776348
3DNA replication_Homo sapiens_hsa030302.50617774
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47887362
5Mismatch repair_Homo sapiens_hsa034302.31785696
6Graft-versus-host disease_Homo sapiens_hsa053322.05247774
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04706565
8Allograft rejection_Homo sapiens_hsa053302.01425807
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96576691
10Antigen processing and presentation_Homo sapiens_hsa046121.91228839
11Measles_Homo sapiens_hsa051621.90040637
12Autoimmune thyroid disease_Homo sapiens_hsa053201.89752675
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85991087
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85591033
15Non-homologous end-joining_Homo sapiens_hsa034501.80928466
16p53 signaling pathway_Homo sapiens_hsa041151.80081648
17Herpes simplex infection_Homo sapiens_hsa051681.71922966
18Homologous recombination_Homo sapiens_hsa034401.69881760
19Small cell lung cancer_Homo sapiens_hsa052221.69509581
20B cell receptor signaling pathway_Homo sapiens_hsa046621.65684708
21Toxoplasmosis_Homo sapiens_hsa051451.64367697
22T cell receptor signaling pathway_Homo sapiens_hsa046601.58608934
23Cell cycle_Homo sapiens_hsa041101.56367811
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.55798046
25Nucleotide excision repair_Homo sapiens_hsa034201.54198212
26Type I diabetes mellitus_Homo sapiens_hsa049401.50661544
27Fanconi anemia pathway_Homo sapiens_hsa034601.50519715
28Base excision repair_Homo sapiens_hsa034101.47455639
29Leishmaniasis_Homo sapiens_hsa051401.46625047
30Epstein-Barr virus infection_Homo sapiens_hsa051691.37614175
31RNA polymerase_Homo sapiens_hsa030201.37354906
32Shigellosis_Homo sapiens_hsa051311.35045546
33One carbon pool by folate_Homo sapiens_hsa006701.34406435
34Hematopoietic cell lineage_Homo sapiens_hsa046401.33123474
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32719704
36Viral myocarditis_Homo sapiens_hsa054161.32654068
37RNA transport_Homo sapiens_hsa030131.27249312
38Asthma_Homo sapiens_hsa053101.23577974
39Influenza A_Homo sapiens_hsa051641.20893115
40Legionellosis_Homo sapiens_hsa051341.20808884
41RNA degradation_Homo sapiens_hsa030181.20470395
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19823317
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.15539503
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13971690
45Tuberculosis_Homo sapiens_hsa051521.12934073
46Viral carcinogenesis_Homo sapiens_hsa052031.12628798
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.06516475
48Osteoclast differentiation_Homo sapiens_hsa043801.06155426
49Apoptosis_Homo sapiens_hsa042101.04539236
50Pyrimidine metabolism_Homo sapiens_hsa002401.01913033
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01092132
52Spliceosome_Homo sapiens_hsa030400.99335223
53Ribosome_Homo sapiens_hsa030100.96944334
54Basal transcription factors_Homo sapiens_hsa030220.96726961
55Hepatitis B_Homo sapiens_hsa051610.95514110
56Acute myeloid leukemia_Homo sapiens_hsa052210.92245011
57Pancreatic cancer_Homo sapiens_hsa052120.90348157
58Non-small cell lung cancer_Homo sapiens_hsa052230.90102705
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87399972
60Thyroid cancer_Homo sapiens_hsa052160.86424160
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84209699
62Chronic myeloid leukemia_Homo sapiens_hsa052200.82346567
63Hepatitis C_Homo sapiens_hsa051600.80953643
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77622024
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77178119
66Malaria_Homo sapiens_hsa051440.77142408
67Systemic lupus erythematosus_Homo sapiens_hsa053220.76048483
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75069934
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69833928
70N-Glycan biosynthesis_Homo sapiens_hsa005100.69710488
71Fatty acid elongation_Homo sapiens_hsa000620.69465222
72TNF signaling pathway_Homo sapiens_hsa046680.65180989
73Sphingolipid metabolism_Homo sapiens_hsa006000.64933884
74HTLV-I infection_Homo sapiens_hsa051660.63636910
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.61239958
76Pentose phosphate pathway_Homo sapiens_hsa000300.57021522
77Chemokine signaling pathway_Homo sapiens_hsa040620.55207293
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52625625
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51234097
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50671324
81Protein export_Homo sapiens_hsa030600.46278450
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44001769
83Prostate cancer_Homo sapiens_hsa052150.43076917
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42212986
85Oxidative phosphorylation_Homo sapiens_hsa001900.41344321
86Parkinsons disease_Homo sapiens_hsa050120.40841583
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39376726
88Galactose metabolism_Homo sapiens_hsa000520.38920589
89Steroid biosynthesis_Homo sapiens_hsa001000.38138324
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37453896
91Renal cell carcinoma_Homo sapiens_hsa052110.36295287
92Salmonella infection_Homo sapiens_hsa051320.35778110
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34098631
94Endocytosis_Homo sapiens_hsa041440.33060519
95Bladder cancer_Homo sapiens_hsa052190.32773285
96Purine metabolism_Homo sapiens_hsa002300.31638704
97Sulfur metabolism_Homo sapiens_hsa009200.31623015
98Rheumatoid arthritis_Homo sapiens_hsa053230.30221076
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.29761385
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28778249

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »