C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.97875586
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97875586
3L-phenylalanine metabolic process (GO:0006558)6.64152554
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64152554
5aromatic amino acid family catabolic process (GO:0009074)6.32647533
6complement activation, alternative pathway (GO:0006957)5.90897682
7tryptophan catabolic process (GO:0006569)5.78727930
8indole-containing compound catabolic process (GO:0042436)5.78727930
9indolalkylamine catabolic process (GO:0046218)5.78727930
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.77113264
11kynurenine metabolic process (GO:0070189)5.54920678
12* regulation of protein activation cascade (GO:2000257)5.53024127
13bile acid biosynthetic process (GO:0006699)5.52273130
14tryptophan metabolic process (GO:0006568)5.45740223
15glyoxylate metabolic process (GO:0046487)5.36152781
16urea metabolic process (GO:0019627)5.30854510
17urea cycle (GO:0000050)5.30854510
18alpha-linolenic acid metabolic process (GO:0036109)5.30249931
19sulfur amino acid catabolic process (GO:0000098)5.27555290
20* regulation of complement activation (GO:0030449)5.25508121
21epoxygenase P450 pathway (GO:0019373)5.21470416
22negative regulation of fibrinolysis (GO:0051918)5.17863794
23peptidyl-glutamic acid carboxylation (GO:0017187)5.15709008
24protein carboxylation (GO:0018214)5.15709008
25cysteine metabolic process (GO:0006534)5.13941931
26high-density lipoprotein particle remodeling (GO:0034375)5.06742712
27exogenous drug catabolic process (GO:0042738)5.04797635
28regulation of fibrinolysis (GO:0051917)5.02672798
29tyrosine metabolic process (GO:0006570)5.00743011
30nitrogen cycle metabolic process (GO:0071941)4.91063614
31regulation of plasminogen activation (GO:0010755)4.88565792
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81532321
33homocysteine metabolic process (GO:0050667)4.81339312
34serine family amino acid catabolic process (GO:0009071)4.78923030
35aromatic amino acid family metabolic process (GO:0009072)4.74869331
36bile acid metabolic process (GO:0008206)4.74459302
37acute-phase response (GO:0006953)4.67531446
38protein-lipid complex assembly (GO:0065005)4.66827934
39regulation of triglyceride catabolic process (GO:0010896)4.62041031
40intestinal cholesterol absorption (GO:0030299)4.61707595
41reverse cholesterol transport (GO:0043691)4.58326454
42plasma lipoprotein particle clearance (GO:0034381)4.48296341
43acylglycerol homeostasis (GO:0055090)4.48265383
44triglyceride homeostasis (GO:0070328)4.48265383
45negative regulation of hemostasis (GO:1900047)4.47555122
46negative regulation of blood coagulation (GO:0030195)4.47555122
47plasma lipoprotein particle remodeling (GO:0034369)4.44184401
48protein-lipid complex remodeling (GO:0034368)4.44184401
49macromolecular complex remodeling (GO:0034367)4.44184401
50omega-hydroxylase P450 pathway (GO:0097267)4.42741323
51regulation of cholesterol esterification (GO:0010872)4.38263752
52protein-lipid complex subunit organization (GO:0071825)4.36255446
53amino-acid betaine metabolic process (GO:0006577)4.35849811
54alpha-amino acid catabolic process (GO:1901606)4.32213008
55lysine metabolic process (GO:0006553)4.31721130
56lysine catabolic process (GO:0006554)4.31721130
57phospholipid efflux (GO:0033700)4.25698039
58* regulation of humoral immune response (GO:0002920)4.19308780
59negative regulation of complement activation (GO:0045916)4.16047201
60cellular glucuronidation (GO:0052695)4.14103520
61bile acid and bile salt transport (GO:0015721)4.13700402
62negative regulation of coagulation (GO:0050819)4.13519626
63positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.10835201
64positive regulation of blood coagulation (GO:0030194)4.10043640
65positive regulation of hemostasis (GO:1900048)4.10043640
66indolalkylamine metabolic process (GO:0006586)4.08285153
67amine catabolic process (GO:0009310)4.02296943
68cellular biogenic amine catabolic process (GO:0042402)4.02296943
69negative regulation of cholesterol transport (GO:0032375)4.01808644
70negative regulation of sterol transport (GO:0032372)4.01808644
71coenzyme catabolic process (GO:0009109)4.01554246
72cellular amino acid catabolic process (GO:0009063)4.01540394
73negative regulation of protein activation cascade (GO:2000258)4.01484980
74opsonization (GO:0008228)3.96085489
75cholesterol efflux (GO:0033344)3.94486244
76glycine metabolic process (GO:0006544)3.94306386
77benzene-containing compound metabolic process (GO:0042537)3.94065791
78ethanol oxidation (GO:0006069)3.93298147
79cellular ketone body metabolic process (GO:0046950)3.90630950
80fibrinolysis (GO:0042730)3.90461815
81positive regulation of fatty acid biosynthetic process (GO:0045723)3.88923973
82negative regulation of wound healing (GO:0061045)3.88741725
83imidazole-containing compound metabolic process (GO:0052803)3.88463889
84serine family amino acid metabolic process (GO:0009069)3.85449600
85lipoprotein metabolic process (GO:0042157)3.85406057
86positive regulation of coagulation (GO:0050820)3.84101352
87phospholipid homeostasis (GO:0055091)3.82548764
88* complement activation (GO:0006956)3.81647551
89plasma lipoprotein particle assembly (GO:0034377)3.79111250
90cellular modified amino acid catabolic process (GO:0042219)3.78589607
91cytolysis (GO:0019835)3.76867534
92glutamate metabolic process (GO:0006536)3.76634792
93regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.75330766
94* regulation of apoptotic cell clearance (GO:2000425)3.75111302
95* protein activation cascade (GO:0072376)3.71225556
96glucuronate metabolic process (GO:0019585)3.71128186
97uronic acid metabolic process (GO:0006063)3.71128186
98* complement activation, classical pathway (GO:0006958)3.70347032
99ethanol metabolic process (GO:0006067)3.70180116
100low-density lipoprotein particle remodeling (GO:0034374)3.69756579
101blood coagulation, intrinsic pathway (GO:0007597)3.68554752
102ketone body metabolic process (GO:1902224)3.66938649
103positive regulation of lipid catabolic process (GO:0050996)3.66571000
104short-chain fatty acid metabolic process (GO:0046459)3.65793137
105drug metabolic process (GO:0017144)3.65578206
106acetyl-CoA metabolic process (GO:0006084)3.64746776
107arginine metabolic process (GO:0006525)3.62489666
108cholesterol homeostasis (GO:0042632)3.60801233
109intestinal absorption (GO:0050892)3.58976657
110aldehyde catabolic process (GO:0046185)3.58901076
111drug catabolic process (GO:0042737)3.58822473
112organic acid catabolic process (GO:0016054)3.58136418
113carboxylic acid catabolic process (GO:0046395)3.58136418
114serine family amino acid biosynthetic process (GO:0009070)3.57592088
115positive regulation of triglyceride lipase activity (GO:0061365)3.56451781
116positive regulation of lipoprotein lipase activity (GO:0051006)3.56451781
117sterol homeostasis (GO:0055092)3.55086706
118fat-soluble vitamin biosynthetic process (GO:0042362)3.55035121
119negative regulation of lipase activity (GO:0060192)3.54782790
120valine metabolic process (GO:0006573)3.54752476
121dicarboxylic acid biosynthetic process (GO:0043650)3.54001125
122regulation of bile acid biosynthetic process (GO:0070857)3.52493011
123acute inflammatory response (GO:0002526)3.51956291
124positive regulation of fatty acid beta-oxidation (GO:0032000)3.49656842
125very-low-density lipoprotein particle assembly (GO:0034379)3.49596742
126plasma lipoprotein particle organization (GO:0071827)3.48449408
127cofactor catabolic process (GO:0051187)3.47269299
128cholesterol transport (GO:0030301)3.41342927
129sterol transport (GO:0015918)3.41342927
130negative regulation of humoral immune response (GO:0002921)3.32997816
131regulation of cholesterol homeostasis (GO:2000188)3.26955545
132positive regulation of extracellular matrix organization (GO:1903055)3.09906181
133* regulation of acute inflammatory response (GO:0002673)3.08752706
134diacylglycerol metabolic process (GO:0046339)3.06727251
135positive regulation of steroid metabolic process (GO:0045940)3.03768808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.86279058
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73280761
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.65440000
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.20085632
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.94743860
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03032956
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.73169807
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.82597662
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67719310
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45374465
11CLOCK_20551151_ChIP-Seq_293T_Human2.16346284
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09706744
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1018953
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92614911
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87240176
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.79161407
17GATA1_22025678_ChIP-Seq_K562_Human1.68861741
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52793966
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.52530306
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48967755
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.40558316
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39102239
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39082594
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.38179801
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35678955
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33303032
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32817076
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31132555
29* HTT_18923047_ChIP-ChIP_STHdh_Human1.30652084
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27572478
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21549048
32* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13920074
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12860606
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08146828
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02506302
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98750804
37ESR1_21235772_ChIP-Seq_MCF-7_Human0.97251793
38* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97216511
39* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97209588
40ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95109819
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94692178
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94350454
43ESR2_21235772_ChIP-Seq_MCF-7_Human0.92556968
44GATA4_25053715_ChIP-Seq_YYC3_Human0.91816713
45* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90923316
46VDR_24787735_ChIP-Seq_THP-1_Human0.90901352
47GATA1_19941827_ChIP-Seq_MEL_Mouse0.88451183
48NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88331562
49SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88061171
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87848687
51TCF4_18268006_ChIP-ChIP_LS174T_Human0.87270641
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84948306
53DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83168091
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82818594
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81811519
56TRIM28_21343339_ChIP-Seq_HEK293_Human0.81334177
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81301163
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81301163
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80399792
60KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78781341
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78408081
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78322379
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76865747
64PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76314404
65TP63_17297297_ChIP-ChIP_HaCaT_Human0.75868843
66* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75377208
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74935794
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74862033
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74841295
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73851784
71RAC3_21632823_ChIP-Seq_H3396_Human0.73833763
72PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71918186
73BCOR_27268052_Chip-Seq_Bcells_Human0.71539355
74STAT4_19710469_ChIP-ChIP_TH1__Mouse0.71376763
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71008355
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70256384
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69273081
78BCL6_27268052_Chip-Seq_Bcells_Human0.68951577
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66569953
80FOXO3_23340844_ChIP-Seq_DLD1_Human0.66398248
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.65972652
82* RARA_24833708_ChIP-Seq_LIVER_Mouse0.65295739
83EGR1_19032775_ChIP-ChIP_M12_Human0.65271383
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64717077
85CEBPB_22108803_ChIP-Seq_LS180_Human0.64624286
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64434734
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64385242
88SOX2_21211035_ChIP-Seq_LN229_Human0.64106785
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63363866
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.60858933
91* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.60795156
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60534111
93SA1_27219007_Chip-Seq_Bcells_Human0.60139829
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.60043157
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.59377508
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58880196
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58444127
98SOX2_20726797_ChIP-Seq_SW620_Human0.57963059
99STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.57937887
100STAT1_17558387_ChIP-Seq_HELA_Human0.56858255
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.56673100
102AR_20517297_ChIP-Seq_VCAP_Human0.56156447
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.55413332
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55084145
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54690408
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54387369
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52802102
108MYC_19915707_ChIP-ChIP_AK7_Human0.52239241
109BCAT_22108803_ChIP-Seq_LS180_Human0.50974239
110ZNF263_19887448_ChIP-Seq_K562_Human0.50540167
111CBP_21632823_ChIP-Seq_H3396_Human0.47497618
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.47451360
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.47168386
114GATA1_19941826_ChIP-Seq_K562_Human0.46959718
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.46136828
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.45907826
117LXR_22292898_ChIP-Seq_THP-1_Human0.45677968
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.45665647
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.45642102
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45501354
121GATA2_19941826_ChIP-Seq_K562_Human0.45038917
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44678024
123P53_21459846_ChIP-Seq_SAOS-2_Human0.44603054
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43747713
125CDX2_22108803_ChIP-Seq_LS180_Human0.43457870
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42821440
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.42417869
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.42320468
129CJUN_26792858_Chip-Seq_BT549_Human0.42046028
130GATA6_25053715_ChIP-Seq_YYC3_Human0.41448771
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.41004093
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.40664496
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.40664496
134TAF2_19829295_ChIP-Seq_ESCs_Human0.40652612
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40488650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.65443527
2MP0005360_urolithiasis7.16152634
3MP0005085_abnormal_gallbladder_physiolo5.87221541
4MP0005365_abnormal_bile_salt5.79580508
5MP0008875_abnormal_xenobiotic_pharmacok4.67444709
6MP0010329_abnormal_lipoprotein_level3.69892065
7MP0003252_abnormal_bile_duct3.67170177
8MP0003806_abnormal_nucleotide_metabolis3.61937430
9MP0009840_abnormal_foam_cell3.04565455
10MP0003191_abnormal_cellular_cholesterol2.74816181
11MP0005332_abnormal_amino_acid2.68614085
12MP0005083_abnormal_biliary_tract2.60940239
13MP0003195_calcinosis2.57186789
14MP0001666_abnormal_nutrient_absorption2.42897915
15MP0004019_abnormal_vitamin_homeostasis2.24935363
16MP0000609_abnormal_liver_physiology2.18260116
17MP0002118_abnormal_lipid_homeostasis2.15984694
18MP0002138_abnormal_hepatobiliary_system1.92832451
19MP0003172_abnormal_lysosome_physiology1.83367076
20MP0002254_reproductive_system_inflammat1.82605942
21MP0005319_abnormal_enzyme/_coenzyme1.79934659
22MP0005670_abnormal_white_adipose1.79825982
23MP0001764_abnormal_homeostasis1.64869470
24MP0003868_abnormal_feces_composition1.58712670
25MP0005584_abnormal_enzyme/coenzyme_acti1.52894180
26MP0003303_peritoneal_inflammation1.52621988
27MP0003186_abnormal_redox_activity1.50333567
28MP0009785_altered_susceptibility_to1.49998226
29MP0003705_abnormal_hypodermis_morpholog1.42364361
30MP0009643_abnormal_urine_homeostasis1.38587788
31MP0009697_abnormal_copulation1.38191506
32MP0003122_maternal_imprinting1.31898705
33MP0005167_abnormal_blood-brain_barrier1.31164317
34MP0003011_delayed_dark_adaptation1.30848866
35MP0008438_abnormal_cutaneous_collagen1.29088390
36MP0005408_hypopigmentation1.27447857
37MP0005647_abnormal_sex_gland1.25542466
38MP0002876_abnormal_thyroid_physiology1.21794795
39MP0009764_decreased_sensitivity_to1.16701234
40MP0000598_abnormal_liver_morphology1.15580233
41MP0004130_abnormal_muscle_cell1.13545802
42MP0006054_spinal_hemorrhage1.10175539
43MP0005451_abnormal_body_composition1.09974737
44MP0010368_abnormal_lymphatic_system1.07471402
45MP0005025_abnormal_response_to1.07334043
46MP0003656_abnormal_erythrocyte_physiolo1.06783412
47MP0000604_amyloidosis1.05682909
48MP0009763_increased_sensitivity_to1.04547858
49MP0003183_abnormal_peptide_metabolism1.04206037
50MP0002419_abnormal_innate_immunity1.02325815
51MP0000685_abnormal_immune_system1.01178731
52MP0005636_abnormal_mineral_homeostasis0.99004305
53MP0001661_extended_life_span0.97996868
54MP0001533_abnormal_skeleton_physiology0.97675637
55MP0005666_abnormal_adipose_tissue0.96573355
56MP0003879_abnormal_hair_cell0.96121853
57MP0002971_abnormal_brown_adipose0.95776446
58MP0008469_abnormal_protein_level0.95635513
59MP0001915_intracranial_hemorrhage0.94918453
60MP0005387_immune_system_phenotype0.94443211
61MP0001790_abnormal_immune_system0.94443211
62MP0005334_abnormal_fat_pad0.93010762
63MP0002148_abnormal_hypersensitivity_rea0.91651631
64MP0010155_abnormal_intestine_physiology0.90950004
65MP0003724_increased_susceptibility_to0.88807731
66MP0009642_abnormal_blood_homeostasis0.86334598
67MP0002089_abnormal_postnatal_growth/wei0.84774140
68MP0001756_abnormal_urination0.78897906
69MP0002933_joint_inflammation0.78817942
70MP0003690_abnormal_glial_cell0.78481767
71MP0005376_homeostasis/metabolism_phenot0.77968655
72MP0002078_abnormal_glucose_homeostasis0.76974273
73MP0001835_abnormal_antigen_presentation0.74274489
74MP0005535_abnormal_body_temperature0.73065012
75MP0009765_abnormal_xenobiotic_induced0.71085056
76MP0000920_abnormal_myelination0.70365561
77MP0002998_abnormal_bone_remodeling0.68525838
78MP0005275_abnormal_skin_tensile0.68312553
79MP0006036_abnormal_mitochondrial_physio0.68022088
80MP0004381_abnormal_hair_follicle0.66974512
81MP0005084_abnormal_gallbladder_morpholo0.66887635
82MP0009115_abnormal_fat_cell0.66483115
83MP0003300_gastrointestinal_ulcer0.65476920
84MP0002837_dystrophic_cardiac_calcinosis0.64219687
85MP0002060_abnormal_skin_morphology0.63874448
86MP0004782_abnormal_surfactant_physiolog0.63713555
87MP0000566_synostosis0.63322229
88MP0005220_abnormal_exocrine_pancreas0.63205942
89MP0002136_abnormal_kidney_physiology0.62610969
90MP0005448_abnormal_energy_balance0.62025205
91MP0005000_abnormal_immune_tolerance0.61466386
92MP0005058_abnormal_lysosome_morphology0.61400273
93MP0000858_altered_metastatic_potential0.60513548
94MP0009333_abnormal_splenocyte_physiolog0.60150876
95MP0003436_decreased_susceptibility_to0.60014650
96MP0000639_abnormal_adrenal_gland0.58332377
97MP0005164_abnormal_response_to0.58219550
98MP0005464_abnormal_platelet_physiology0.57606250
99MP0005257_abnormal_intraocular_pressure0.57187524
100MP0000343_altered_response_to0.56044486
101MP0004185_abnormal_adipocyte_glucose0.55986398
102MP0001800_abnormal_humoral_immune0.55915795
103MP0005409_darkened_coat_color0.54266245
104MP0005671_abnormal_response_to0.52689711
105MP0001853_heart_inflammation0.51962593
106MP0004883_abnormal_blood_vessel0.51803669
107MP0002723_abnormal_immune_serum0.51639201
108MP0001881_abnormal_mammary_gland0.50823180
109MP0009053_abnormal_anal_canal0.50528172
110MP0000249_abnormal_blood_vessel0.49219109
111MP0002796_impaired_skin_barrier0.48808895
112MP0005395_other_phenotype0.48706242
113MP0005248_abnormal_Harderian_gland0.47682163
114MP0003632_abnormal_nervous_system0.47196478
115MP0002970_abnormal_white_adipose0.46801930
116MP0005375_adipose_tissue_phenotype0.46797811
117MP0005266_abnormal_metabolism0.45029119
118MP0002168_other_aberrant_phenotype0.44913790
119MP0003638_abnormal_response/metabolism_0.43291374
120MP0003953_abnormal_hormone_level0.43255235
121MP0009384_cardiac_valve_regurgitation0.43014910
122MP0002295_abnormal_pulmonary_circulatio0.41654006
123MP0003075_altered_response_to0.41549410
124MP0006082_CNS_inflammation0.40428983
125MP0005166_decreased_susceptibility_to0.40385279
126MP0000230_abnormal_systemic_arterial0.39784795
127MP0001243_abnormal_dermal_layer0.38754792
128MP0003329_amyloid_beta_deposits0.37624266
129MP0000371_diluted_coat_color0.36998850
130MP0001845_abnormal_inflammatory_respons0.36950886
131MP0002928_abnormal_bile_duct0.36637532
132MP0005023_abnormal_wound_healing0.35593256
133MP0001324_abnormal_eye_pigmentation0.34848308
134MP0002132_abnormal_respiratory_system0.34717392
135MP0008873_increased_physiological_sensi0.33716051

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.05203193
2Intrahepatic cholestasis (HP:0001406)6.88739578
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.74090288
4Complement deficiency (HP:0004431)6.27415521
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.18721597
6Prolonged partial thromboplastin time (HP:0003645)6.15186981
7Xanthomatosis (HP:0000991)6.13001766
8Hypobetalipoproteinemia (HP:0003563)5.62854150
9Hyperlipoproteinemia (HP:0010980)5.28066473
10Joint hemorrhage (HP:0005261)4.65067700
11Abnormality of complement system (HP:0005339)4.60071132
12Hypolipoproteinemia (HP:0010981)4.57672155
13Epidermoid cyst (HP:0200040)4.49727258
14Hyperammonemia (HP:0001987)4.42224282
15Hyperglycinemia (HP:0002154)4.40474836
16Abnormality of the common coagulation pathway (HP:0010990)4.40469001
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38229271
18Hyperglycinuria (HP:0003108)4.31471230
19Hypoalphalipoproteinemia (HP:0003233)4.31182781
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25646918
21Abnormality of serine family amino acid metabolism (HP:0010894)4.11528564
22Abnormality of glycine metabolism (HP:0010895)4.11528564
23Ketosis (HP:0001946)4.04972029
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.95458541
25Fat malabsorption (HP:0002630)3.90280764
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.82824572
27Abnormality of methionine metabolism (HP:0010901)3.79440991
28Abnormality of the intrinsic pathway (HP:0010989)3.69916198
29Hypoglycemic coma (HP:0001325)3.69624929
30Conjugated hyperbilirubinemia (HP:0002908)3.62592769
31Hypercholesterolemia (HP:0003124)3.50496476
32Abnormality of pyrimidine metabolism (HP:0004353)3.48978856
33Abnormality of fatty-acid metabolism (HP:0004359)3.34028858
34Myocardial infarction (HP:0001658)3.27258372
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22654817
36Hyperbilirubinemia (HP:0002904)3.07304829
37Spontaneous abortion (HP:0005268)3.07216027
38Abnormality of nucleobase metabolism (HP:0010932)3.05618656
39Hepatocellular carcinoma (HP:0001402)3.01699382
40Abnormality of serum amino acid levels (HP:0003112)2.94037578
41Steatorrhea (HP:0002570)2.93824722
42Ketoacidosis (HP:0001993)2.91986379
43Abnormality of purine metabolism (HP:0004352)2.83938557
44Skin nodule (HP:0200036)2.82996094
45Delayed CNS myelination (HP:0002188)2.80065055
46* Systemic lupus erythematosus (HP:0002725)2.76317281
47* Purpura (HP:0000979)2.75167599
48Recurrent gram-negative bacterial infections (HP:0005420)2.70150347
49Glomerulonephritis (HP:0000099)2.67825098
50Vacuolated lymphocytes (HP:0001922)2.67352801
51Mucopolysacchariduria (HP:0008155)2.61261458
52Urinary glycosaminoglycan excretion (HP:0003541)2.61261458
53Metabolic acidosis (HP:0001942)2.58664536
54Vascular calcification (HP:0004934)2.57380097
55Amyloidosis (HP:0011034)2.57047157
56Pulmonary embolism (HP:0002204)2.56810415
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56523935
58Abnormality of polysaccharide metabolism (HP:0011012)2.56523935
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56523935
60Hypochromic microcytic anemia (HP:0004840)2.54266737
61Abnormality of glycolipid metabolism (HP:0010969)2.52435337
62Abnormality of liposaccharide metabolism (HP:0010968)2.52435337
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.52435337
64Dysostosis multiplex (HP:0000943)2.48153507
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47029865
66Dicarboxylic aciduria (HP:0003215)2.47029865
67Lethargy (HP:0001254)2.45740821
68Hydroxyprolinuria (HP:0003080)2.43599346
69Abnormality of proline metabolism (HP:0010907)2.43599346
70Mitral stenosis (HP:0001718)2.41382016
71Gout (HP:0001997)2.41195800
72Cardiovascular calcification (HP:0011915)2.38654894
73Spastic diplegia (HP:0001264)2.38114649
74Gingival bleeding (HP:0000225)2.37889979
75Hypoglycemic seizures (HP:0002173)2.35072386
76Hemorrhage of the eye (HP:0011885)2.34856914
77Pancreatitis (HP:0001733)2.34230618
78Esophageal varix (HP:0002040)2.29453227
79Acanthocytosis (HP:0001927)2.28546857
80Orchitis (HP:0100796)2.27442433
81Abnormal gallbladder morphology (HP:0012437)2.23400573
82Increased serum ferritin (HP:0003281)2.23348603
83Abnormal cartilage morphology (HP:0002763)2.21676328
84Hypertriglyceridemia (HP:0002155)2.19828931
85Neonatal onset (HP:0003623)2.19125654
86Optic neuritis (HP:0100653)2.18918956
87Retrobulbar optic neuritis (HP:0100654)2.18918956
88Generalized aminoaciduria (HP:0002909)2.18341196
89Cholelithiasis (HP:0001081)2.17165404
90Malnutrition (HP:0004395)2.16963784
91Irritability (HP:0000737)2.14774331
92Gangrene (HP:0100758)2.14456666
93Hypophosphatemic rickets (HP:0004912)2.14398830
94Nephritis (HP:0000123)2.13471520
95Cerebral edema (HP:0002181)2.12764550
96Enlarged kidneys (HP:0000105)2.09514762
97Menorrhagia (HP:0000132)2.08227823
98Sensorimotor neuropathy (HP:0007141)2.05942297
99Vomiting (HP:0002013)2.05645295
100Abnormal gallbladder physiology (HP:0012438)2.04520372
101Cholecystitis (HP:0001082)2.04520372
102Thrombophlebitis (HP:0004418)2.03549579
103Joint swelling (HP:0001386)2.03448194
104Arthropathy (HP:0003040)2.01826783
105Epistaxis (HP:0000421)1.98830228
106Brushfield spots (HP:0001088)1.97960003
107Potter facies (HP:0002009)1.96695724
108Facial shape deformation (HP:0011334)1.96695724
109Opisthotonus (HP:0002179)1.92440860
110Osteomalacia (HP:0002749)1.90114385
111Nausea (HP:0002018)1.89430403
112Myositis (HP:0100614)1.88629316
113Abnormality of iron homeostasis (HP:0011031)1.88259848
114Proximal tubulopathy (HP:0000114)1.87507771
115Retinal atrophy (HP:0001105)1.87493145
116Abnormality of transition element cation homeostasis (HP:0011030)1.87155083
117Increased cerebral lipofuscin (HP:0011813)1.86943593
118Widely patent fontanelles and sutures (HP:0004492)1.85271127
119Renal cortical cysts (HP:0000803)1.84551888
120Alkalosis (HP:0001948)1.83367828
121Late onset (HP:0003584)1.82251303
122Abnormality of the gallbladder (HP:0005264)1.82134771
123Abnormality of the lumbar spine (HP:0100712)1.81895384
124Rickets (HP:0002748)1.81362102
125Abnormality of carpal bone ossification (HP:0006257)1.81341335
126Hyperuricemia (HP:0002149)1.79609494
127Increased purine levels (HP:0004368)1.79609494
128Abnormal enzyme/coenzyme activity (HP:0012379)1.78856753
129Elevated hepatic transaminases (HP:0002910)1.77979118
130Hyperglycemia (HP:0003074)1.77000847
131Abnormal tarsal ossification (HP:0008369)1.74389062
132Metaphyseal irregularity (HP:0003025)1.71160116
133Abnormality of the Achilles tendon (HP:0005109)1.70258972
134Hypophosphatemia (HP:0002148)1.69973227
135Gastrointestinal infarctions (HP:0005244)1.65624451
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.64906833
137Abnormality of macrophages (HP:0004311)1.61804362
138Poikilocytosis (HP:0004447)1.59829504
139Peritonitis (HP:0002586)1.58136509
140Flat acetabular roof (HP:0003180)1.57314558
141Neurofibrillary tangles (HP:0002185)1.56607123
142Pigmentary retinal degeneration (HP:0001146)1.55085766
143Elevated alkaline phosphatase (HP:0003155)1.54618110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.90850278
2ERN14.46554030
3FGFR44.23471807
4SIK14.16165793
5MST1R3.94580592
6INSRR2.64968295
7TAOK32.57089583
8TRIB32.40237628
9ERBB42.28280643
10DDR22.23862229
11ICK2.20882874
12BLK1.97622388
13WNK41.97026594
14LATS11.88693586
15TYK21.82781115
16ACVR1B1.79036517
17MAPK111.69566748
18EPHA31.66272450
19TGFBR21.65388801
20CAMK1D1.64022178
21TIE11.61873952
22MATK1.59394209
23MET1.58900089
24PKN21.56341736
25PIK3CG1.52789179
26FRK1.51575289
27CDC42BPA1.51118065
28FGFR21.51088840
29TYRO31.50958647
30NEK91.49534382
31FLT31.46466963
32PTK61.40022466
33ABL21.39046923
34MAP2K41.38340980
35IRAK31.37300356
36MAP3K141.35113354
37FGR1.26677512
38JAK11.26434009
39PRKAA21.25370421
40GRK71.23305982
41MAP3K31.22138371
42MAP2K31.21117077
43TBK11.20765327
44JAK21.19941851
45EPHB11.18948484
46ZAP701.10081269
47FGFR31.09544601
48KDR1.05640692
49STK38L1.03964915
50MAP3K11.00820983
51ADRBK21.00433646
52PDK10.92154707
53SIK20.91792808
54MAPKAPK30.90430825
55RIPK10.90383828
56MYLK0.90344104
57MAP4K10.89336357
58CAMKK20.85582098
59PINK10.85259400
60GSK3A0.84962908
61DAPK20.84439020
62IKBKE0.83426580
63MAP3K70.82394090
64CDK60.81669135
65MAPK120.81477241
66CAMK1G0.80805883
67MAPK40.79855578
68BMX0.79594391
69TXK0.74845633
70ERBB20.74181053
71PDGFRA0.73406270
72MAP3K100.69276602
73CSK0.69076444
74PRKCZ0.67307529
75EPHB20.67195068
76MAP3K20.67072282
77LYN0.65784418
78PRKAA10.64622122
79SGK30.64132931
80SYK0.63147963
81PRKACG0.61671648
82PIM20.61454646
83WNK10.60857744
84TAOK10.59767575
85LCK0.58191390
86PDK30.56886024
87PDK40.56886024
88IGF1R0.56875353
89MAP3K60.54634777
90RIPK40.53630174
91MAPK150.53123954
92SGK20.52950889
93IRAK10.52495699
94PDPK10.51327751
95JAK30.50656253
96MAP2K10.50654024
97MAP3K50.50619036
98PRKG20.50301500
99CDK120.50177081
100PDK20.48575177
101CAMK2G0.46803782
102PTK20.46250976
103SRC0.46096491
104STK30.45732769
105FER0.45009302
106MAPK70.44407316
107IRAK40.44052141
108AKT30.43717389
109MAP2K60.43687019
110SGK10.41259017
111GRK10.40830816
112DYRK1B0.40702085
113GRK60.40275326
114ITK0.39174447
115PIK3CA0.36594803
116SGK2230.35934035
117SGK4940.35934035
118MAP2K20.35434475
119CSNK1G10.35368016
120MAP3K110.35033601
121PRKG10.33509540
122NUAK10.32546648
123CSF1R0.32509226
124ABL10.32283293
125MTOR0.31594964
126NLK0.31192332
127EPHA20.30478364
128MAP3K130.30158193
129PDGFRB0.29924618
130KIT0.29516150
131PRPF4B0.29195470
132CHUK0.29118454
133CDK40.29066307
134FGFR10.28828304
135TAOK20.28723672
136RET0.26292388
137EGFR0.26273206
138IKBKB0.25989106
139MAPK30.25466297

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32473797
2Nitrogen metabolism_Homo sapiens_hsa009103.51805458
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17457857
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04995999
5Arginine biosynthesis_Homo sapiens_hsa002202.89231559
6* Complement and coagulation cascades_Homo sapiens_hsa046102.86770327
7Tryptophan metabolism_Homo sapiens_hsa003802.67055533
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56111474
9Fatty acid degradation_Homo sapiens_hsa000712.50974678
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48629212
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47429057
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46523769
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27016032
14PPAR signaling pathway_Homo sapiens_hsa033202.12766598
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11579116
16Peroxisome_Homo sapiens_hsa041462.10095037
17Propanoate metabolism_Homo sapiens_hsa006402.09446929
18Butanoate metabolism_Homo sapiens_hsa006502.01099776
19Caffeine metabolism_Homo sapiens_hsa002321.98190816
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.96973386
21Chemical carcinogenesis_Homo sapiens_hsa052041.90614129
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90613337
23Histidine metabolism_Homo sapiens_hsa003401.90149693
24Other glycan degradation_Homo sapiens_hsa005111.88844312
25Fatty acid metabolism_Homo sapiens_hsa012121.88191921
26* Staphylococcus aureus infection_Homo sapiens_hsa051501.86020336
27beta-Alanine metabolism_Homo sapiens_hsa004101.78527544
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.67630691
29Retinol metabolism_Homo sapiens_hsa008301.66648516
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66560938
31Tyrosine metabolism_Homo sapiens_hsa003501.64863638
32Phenylalanine metabolism_Homo sapiens_hsa003601.63653413
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55451408
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52749828
35Selenocompound metabolism_Homo sapiens_hsa004501.48651140
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39993353
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39305695
38Bile secretion_Homo sapiens_hsa049761.38005786
39Pyruvate metabolism_Homo sapiens_hsa006201.36956160
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31466756
41Sulfur metabolism_Homo sapiens_hsa009201.31423000
42Fat digestion and absorption_Homo sapiens_hsa049751.28475808
43ABC transporters_Homo sapiens_hsa020101.24041233
44Fatty acid elongation_Homo sapiens_hsa000621.23065328
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16222889
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.16135306
47* Pertussis_Homo sapiens_hsa051331.14408454
48Folate biosynthesis_Homo sapiens_hsa007901.13546549
49Carbon metabolism_Homo sapiens_hsa012001.12135773
50Biosynthesis of amino acids_Homo sapiens_hsa012301.08479832
51Vitamin B6 metabolism_Homo sapiens_hsa007501.08348320
52Steroid biosynthesis_Homo sapiens_hsa001001.07671143
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.00777677
54Vitamin digestion and absorption_Homo sapiens_hsa049770.97467198
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94723791
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94563820
57Arginine and proline metabolism_Homo sapiens_hsa003300.92381941
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85745424
59Glycerolipid metabolism_Homo sapiens_hsa005610.84956247
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.84383298
61Sulfur relay system_Homo sapiens_hsa041220.82060428
62Fatty acid biosynthesis_Homo sapiens_hsa000610.81923931
63Glutathione metabolism_Homo sapiens_hsa004800.80551019
64Lysine degradation_Homo sapiens_hsa003100.76219381
65Asthma_Homo sapiens_hsa053100.69835954
66Mineral absorption_Homo sapiens_hsa049780.68034790
67Pentose phosphate pathway_Homo sapiens_hsa000300.64464553
68One carbon pool by folate_Homo sapiens_hsa006700.64422376
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63364575
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52599702
71Allograft rejection_Homo sapiens_hsa053300.51090405
72Metabolic pathways_Homo sapiens_hsa011000.46128255
73Prion diseases_Homo sapiens_hsa050200.45862008
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41948030
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.41422755
76Leishmaniasis_Homo sapiens_hsa051400.40813552
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40371452
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.38179171
79Autoimmune thyroid disease_Homo sapiens_hsa053200.37227114
80Graft-versus-host disease_Homo sapiens_hsa053320.35519413
81Linoleic acid metabolism_Homo sapiens_hsa005910.34744374
82Sphingolipid metabolism_Homo sapiens_hsa006000.33425082
83Insulin resistance_Homo sapiens_hsa049310.31647600
84Galactose metabolism_Homo sapiens_hsa000520.29030430
85Type I diabetes mellitus_Homo sapiens_hsa049400.27824058
86Fructose and mannose metabolism_Homo sapiens_hsa000510.27322086
87Rheumatoid arthritis_Homo sapiens_hsa053230.27089521
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26380569
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.24644838
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.23033533
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20200688
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.19259001
93Tuberculosis_Homo sapiens_hsa051520.18742022
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18016769
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17386009
96Antigen processing and presentation_Homo sapiens_hsa046120.15866961
97Phagosome_Homo sapiens_hsa041450.15738351
98Ether lipid metabolism_Homo sapiens_hsa005650.15321417
99Osteoclast differentiation_Homo sapiens_hsa043800.14468526
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.14176081
101AMPK signaling pathway_Homo sapiens_hsa041520.12245569
102Arachidonic acid metabolism_Homo sapiens_hsa005900.11525191
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08902124
104Glucagon signaling pathway_Homo sapiens_hsa049220.07060355
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03303727
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2029228
107ECM-receptor interaction_Homo sapiens_hsa04512-0.1993376
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1969795
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1852397
110Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1592224
111Malaria_Homo sapiens_hsa05144-0.1431589
112Protein digestion and absorption_Homo sapiens_hsa04974-0.1211187
113Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1203448
114African trypanosomiasis_Homo sapiens_hsa05143-0.1066361
115Renin-angiotensin system_Homo sapiens_hsa04614-0.0994533
116Hepatitis C_Homo sapiens_hsa05160-0.0985837
117Amoebiasis_Homo sapiens_hsa05146-0.0981835
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0856254
119Regulation of autophagy_Homo sapiens_hsa04140-0.0772547
120Insulin signaling pathway_Homo sapiens_hsa04910-0.0557604
121Lysosome_Homo sapiens_hsa04142-0.0542209
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0444217
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0110915

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