ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA packaging (GO:0006323)	9.77240582
2	sperm capacitation (GO:0048240)	9.43951636
3	single strand break repair (GO:0000012)	8.76394014
4	plasma membrane fusion (GO:0045026)	8.75136999
5	spermatid nucleus differentiation (GO:0007289)	8.72549348
6	microtubule depolymerization (GO:0007019)	8.50396805
7	spermatid development (GO:0007286)	8.12686902
8	sperm-egg recognition (GO:0035036)	7.82560574
9	sexual reproduction (GO:0019953)	7.54386769
10	binding of sperm to zona pellucida (GO:0007339)	7.48572906
11	rRNA methylation (GO:0031167)	7.06211184
12	multicellular organism reproduction (GO:0032504)	7.03244949
13	negative regulation of inclusion body assembly (GO:0090084)	7.00701873
14	reproduction (GO:0000003)	6.92549526
15	microtubule polymerization or depolymerization (GO:0031109)	6.77770551
16	calcium ion-dependent exocytosis (GO:0017156)	6.74962108
17	cell-cell recognition (GO:0009988)	6.42552428
18	protein polyglutamylation (GO:0018095)	6.36051472
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	6.16346201
20	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.13713069
21	axonemal dynein complex assembly (GO:0070286)	6.10679111
22	spermatogenesis (GO:0007283)	6.09043809
23	cellular ketone body metabolic process (GO:0046950)	6.07816645
24	male gamete generation (GO:0048232)	6.06930145
25	rRNA modification (GO:0000154)	5.96293285
26	protein targeting to Golgi (GO:0000042)	5.90894615
27	establishment of protein localization to Golgi (GO:0072600)	5.66036157
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.65239570
29	microtubule severing (GO:0051013)	5.60840598
30	gamete generation (GO:0007276)	5.53997046
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.48432935
32	ketone body metabolic process (GO:1902224)	5.36254156
33	positive regulation of Rab GTPase activity (GO:0032851)	5.15794508
34	regulation of Rab GTPase activity (GO:0032313)	5.15794508
35	chromatin silencing (GO:0006342)	5.12474199
36	regulation of inclusion body assembly (GO:0090083)	4.99539769
37	centriole replication (GO:0007099)	4.99306702
38	motile cilium assembly (GO:0044458)	4.94195337
39	regulation of cilium movement (GO:0003352)	4.90987989
40	single fertilization (GO:0007338)	4.85141108
41	germ cell development (GO:0007281)	4.58406722
42	regulation of transcription involved in cell fate commitment (GO:0060850)	4.52429946
43	coenzyme catabolic process (GO:0009109)	4.45987353
44	multicellular organismal reproductive process (GO:0048609)	4.44887258
45	centriole assembly (GO:0098534)	4.44620334
46	cell wall macromolecule catabolic process (GO:0016998)	4.43722787
47	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.38575823
48	RNA destabilization (GO:0050779)	4.31795422
49	protein localization to Golgi apparatus (GO:0034067)	4.23699667
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.19350330
51	cell wall macromolecule metabolic process (GO:0044036)	4.18420208
52	nucleus organization (GO:0006997)	4.18294361
53	negative regulation of Rho protein signal transduction (GO:0035024)	4.11995445
54	glycerol ether metabolic process (GO:0006662)	4.10346274
55	regulation of centriole replication (GO:0046599)	4.07564783
56	fertilization (GO:0009566)	3.92435146
57	ether metabolic process (GO:0018904)	3.78445779
58	epithelial cilium movement (GO:0003351)	3.57612284
59	seminiferous tubule development (GO:0072520)	3.56775504
60	protein-DNA complex disassembly (GO:0032986)	3.55319044
61	nucleosome disassembly (GO:0006337)	3.55319044
62	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.54365713
63	negative regulation of gene expression, epigenetic (GO:0045814)	3.50581116
64	organic cation transport (GO:0015695)	3.45207263
65	polyamine biosynthetic process (GO:0006596)	3.44303366
66	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.43936886
67	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.43936886
68	musculoskeletal movement (GO:0050881)	3.42005216
69	multicellular organismal movement (GO:0050879)	3.42005216
70	response to acidic pH (GO:0010447)	3.38392826
71	regulation of microtubule-based movement (GO:0060632)	3.37305650
72	peptidyl-threonine dephosphorylation (GO:0035970)	3.34914896
73	cranial nerve morphogenesis (GO:0021602)	3.30947888
74	regulation of somitogenesis (GO:0014807)	3.30297933
75	histone H3-K9 demethylation (GO:0033169)	3.29399944
76	cell differentiation involved in metanephros development (GO:0072202)	3.28384965
77	regulation of interleukin-13 production (GO:0032656)	3.27840614
78	cerebral cortex neuron differentiation (GO:0021895)	3.27329591
79	regulation of T-helper 2 cell differentiation (GO:0045628)	3.24555478
80	protein depolymerization (GO:0051261)	3.22410870
81	glomerular visceral epithelial cell development (GO:0072015)	3.22185598
82	DNA conformation change (GO:0071103)	3.15970128
83	cellular response to pH (GO:0071467)	3.15650785
84	cilium movement (GO:0003341)	3.15125345
85	glomerular epithelial cell development (GO:0072310)	3.13907775
86	NAD biosynthetic process (GO:0009435)	3.09534820
87	peptidyl-proline hydroxylation (GO:0019511)	3.07155198
88	cell recognition (GO:0008037)	3.06619379
89	homeostasis of number of cells within a tissue (GO:0048873)	3.05847851
90	membrane protein intracellular domain proteolysis (GO:0031293)	3.04609386
91	multicellular organismal development (GO:0007275)	2.96163562
92	tooth mineralization (GO:0034505)	2.91799688
93	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.89848028
94	metanephric mesenchyme development (GO:0072075)	2.83775691
95	negative regulation of histone methylation (GO:0031061)	2.81799873
96	acrosome reaction (GO:0007340)	12.6797183
97	sperm motility (GO:0030317)	11.5809648
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.5332099
99	response to pheromone (GO:0019236)	10.4563942
100	chromosome condensation (GO:0030261)	10.2530011

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.12321688
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.04623599
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.85869932
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34482886
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.34482886
6	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.33375710
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.19941610
8	ERA_21632823_ChIP-Seq_H3396_Human	2.13191705
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.11016588
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.11016588
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09484062
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.08142607
13	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.00021350
14	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.98456355
15	RAC3_21632823_ChIP-Seq_H3396_Human	1.97748133
16	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.93524500
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.93076380
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89827808
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.89684518
20	BCL6_27268052_Chip-Seq_Bcells_Human	1.84174300
21	E2F1_20622854_ChIP-Seq_HELA_Human	1.82318020
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.79861446
23	SMC4_20622854_ChIP-Seq_HELA_Human	1.78661351
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.74526971
25	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.73137223
26	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.70157394
27	P68_20966046_ChIP-Seq_HELA_Human	1.69354155
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.69055542
29	FUS_26573619_Chip-Seq_HEK293_Human	1.68138428
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67911507
31	PHF8_20622854_ChIP-Seq_HELA_Human	1.67161507
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66852747
33	CTCF_20526341_ChIP-Seq_ESCs_Human	1.64536661
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63524065
35	LXR_22292898_ChIP-Seq_THP-1_Human	1.62885896
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.62775825
37	TP63_22573176_ChIP-Seq_HFKS_Human	1.61247167
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.56117627
39	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.54904291
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.54723851
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.49930590
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.49067446
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.47236308
44	TP53_18474530_ChIP-ChIP_U2OS_Human	1.46026054
45	P300_27268052_Chip-Seq_Bcells_Human	1.45054577
46	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.44277281
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43337051
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42806869
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.39185579
50	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.34464624
51	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34085266
52	RBPJ_21746931_ChIP-Seq_IB4_Human	1.33571404
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33476181
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32413652
55	AR_25329375_ChIP-Seq_VCAP_Human	1.32260445
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32037080
57	EZH2_22144423_ChIP-Seq_EOC_Human	1.31785485
58	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30926652
59	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.30538786
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30185765
61	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.29622934
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.26868829
63	SA1_27219007_Chip-Seq_Bcells_Human	1.26291677
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.26284354
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.24559889
66	CEBPB_22108803_ChIP-Seq_LS180_Human	1.24253264
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23331091
68	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.22695054
69	RUNX_20019798_ChIP-Seq_JUKART_Human	1.22207204
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18435718
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.16997137
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16533025
73	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.16154618
74	NFYB_21822215_ChIP-Seq_K562_Human	1.15213530
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14718384
76	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.14454174
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13679451
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.13528852
79	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12812913
80	TBL1_22424771_ChIP-Seq_293T_Human	1.11740231
81	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11082913
82	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.11078240
83	SMRT_27268052_Chip-Seq_Bcells_Human	1.10980394
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10782596
85	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.10483178
86	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09857977
87	PHF8_20622853_ChIP-Seq_HELA_Human	1.09164852
88	P300_19829295_ChIP-Seq_ESCs_Human	1.07153295
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05920592
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04990067
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04524670
92	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.02068240
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99318482
94	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.99193012
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.98957844
96	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98534521
97	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98376065
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98245746
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98245746
100	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98229207

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.90038225
2	MP0003878_abnormal_ear_physiology	4.90038225
3	MP0005670_abnormal_white_adipose	4.52642506
4	MP0003698_abnormal_male_reproductive	4.45721753
5	MP0001348_abnormal_lacrimal_gland	3.89204565
6	MP0001929_abnormal_gametogenesis	3.82276651
7	MP0000678_abnormal_parathyroid_gland	3.07312097
8	MP0002161_abnormal_fertility/fecundity	2.50813384
9	MP0003011_delayed_dark_adaptation	2.50039706
10	MP0002132_abnormal_respiratory_system	2.33017746
11	MP0003718_maternal_effect	2.29186737
12	MP0005410_abnormal_fertilization	12.7687350
13	MP0002234_abnormal_pharynx_morphology	1.96444469
14	MP0002249_abnormal_larynx_morphology	1.82547146
15	MP0003646_muscle_fatigue	1.82230029
16	MP0005379_endocrine/exocrine_gland_phen	1.81661166
17	MP0005423_abnormal_somatic_nervous	1.68284436
18	MP0004510_myositis	1.63447028
19	MP0009053_abnormal_anal_canal	1.63190674
20	MP0002210_abnormal_sex_determination	1.56749300
21	MP0002282_abnormal_trachea_morphology	1.50510074
22	MP0001145_abnormal_male_reproductive	1.32723828
23	MP0001486_abnormal_startle_reflex	1.29135934
24	MP0000534_abnormal_ureter_morphology	1.28853139
25	MP0005310_abnormal_salivary_gland	1.26019847
26	MP0000653_abnormal_sex_gland	1.24665074
27	MP0001485_abnormal_pinna_reflex	1.23043447
28	MP0002127_abnormal_cardiovascular_syste	1.20255667
29	MP0005248_abnormal_Harderian_gland	1.19801649
30	MP0002735_abnormal_chemical_nociception	1.17254019
31	MP0001765_abnormal_ion_homeostasis	1.16564225
32	MP0001968_abnormal_touch/_nociception	1.12146930
33	MP0004742_abnormal_vestibular_system	1.11770500
34	MP0000681_abnormal_thyroid_gland	1.08162840
35	MP0004859_abnormal_synaptic_plasticity	1.07070917
36	MP0005395_other_phenotype	1.06345783
37	MP0002138_abnormal_hepatobiliary_system	1.05272647
38	MP0001963_abnormal_hearing_physiology	0.97716977
39	MP0000049_abnormal_middle_ear	0.95512369
40	MP0000026_abnormal_inner_ear	0.93480936
41	MP0002822_catalepsy	0.92652032
42	MP0003879_abnormal_hair_cell	0.87770365
43	MP0000516_abnormal_urinary_system	0.84088257
44	MP0005367_renal/urinary_system_phenotyp	0.84088257
45	MP0001879_abnormal_lymphatic_vessel	0.80414516
46	MP0002229_neurodegeneration	0.79991524
47	MP0000955_abnormal_spinal_cord	0.79886338
48	MP0005623_abnormal_meninges_morphology	0.79166528
49	MP0005451_abnormal_body_composition	0.78688759
50	MP0002733_abnormal_thermal_nociception	0.74751478
51	MP0005083_abnormal_biliary_tract	0.74708341
52	MP0004085_abnormal_heartbeat	0.70715236
53	MP0005666_abnormal_adipose_tissue	0.68576348
54	MP0009115_abnormal_fat_cell	0.68263399
55	MP0005375_adipose_tissue_phenotype	0.66958161
56	MP0004233_abnormal_muscle_weight	0.65794179
57	MP0000003_abnormal_adipose_tissue	0.65750152
58	MP0005636_abnormal_mineral_homeostasis	0.64913310
59	MP0002067_abnormal_sensory_capabilities	0.63692812
60	MP0009697_abnormal_copulation	0.63569771
61	MP0008569_lethality_at_weaning	0.63237163
62	MP0005551_abnormal_eye_electrophysiolog	0.58703018
63	MP0004484_altered_response_of	0.58446121
64	MP0003077_abnormal_cell_cycle	0.55719832
65	MP0002557_abnormal_social/conspecific_i	0.55038319
66	MP0001905_abnormal_dopamine_level	0.54724504
67	MP0001666_abnormal_nutrient_absorption	0.53740229
68	MP0008877_abnormal_DNA_methylation	0.53311674
69	MP0001970_abnormal_pain_threshold	0.48010642
70	MP0005167_abnormal_blood-brain_barrier	0.47616235
71	MP0003119_abnormal_digestive_system	0.46714525
72	MP0000249_abnormal_blood_vessel	0.46634853
73	MP0005253_abnormal_eye_physiology	0.45964465
74	MP0002653_abnormal_ependyma_morphology	0.45854012
75	MP0006292_abnormal_olfactory_placode	0.45695137
76	MP0002572_abnormal_emotion/affect_behav	0.44676145
77	MP0000613_abnormal_salivary_gland	0.44066315
78	MP0003137_abnormal_impulse_conducting	0.43187734
79	MP0004036_abnormal_muscle_relaxation	0.41889739
80	MP0003699_abnormal_female_reproductive	0.41765747
81	MP0008995_early_reproductive_senescence	0.41373305
82	MP0008961_abnormal_basal_metabolism	0.41354923
83	MP0003936_abnormal_reproductive_system	0.41157859
84	MP0005535_abnormal_body_temperature	0.40641875
85	MP0000566_synostosis	0.39014204
86	MP0000470_abnormal_stomach_morphology	0.38936010
87	MP0000467_abnormal_esophagus_morphology	0.38511619
88	MP0002272_abnormal_nervous_system	0.37754958
89	MP0002734_abnormal_mechanical_nocicepti	0.35929943
90	MP0003942_abnormal_urinary_system	0.35853775
91	MP0005408_hypopigmentation	0.35178709
92	MP0003091_abnormal_cell_migration	0.34497091
93	MP0003880_abnormal_central_pattern	0.33758103
94	MP0001440_abnormal_grooming_behavior	0.32388929
95	MP0002928_abnormal_bile_duct	0.30377923
96	MP0009745_abnormal_behavioral_response	0.30141885
97	MP0005166_decreased_susceptibility_to	0.29776748
98	MP0003172_abnormal_lysosome_physiology	0.29733175
99	MP0005084_abnormal_gallbladder_morpholo	0.29570612
100	MP0005647_abnormal_sex_gland	0.28844217

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.02509537
2	Absent/shortened dynein arms (HP:0200106)	5.92192953
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.92192953
4	Asymmetric septal hypertrophy (HP:0001670)	5.33489730
5	Attenuation of retinal blood vessels (HP:0007843)	5.27247216
6	Bony spicule pigmentary retinopathy (HP:0007737)	5.26267742
7	Resting tremor (HP:0002322)	4.71336614
8	Bell-shaped thorax (HP:0001591)	4.64451954
9	Abnormal ciliary motility (HP:0012262)	4.55806968
10	Abnormal respiratory motile cilium physiology (HP:0012261)	4.46459833
11	Abnormal rod and cone electroretinograms (HP:0008323)	4.37340173
12	Nasal polyposis (HP:0100582)	4.36647306
13	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.30391544
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.29560683
15	Abnormal respiratory motile cilium morphology (HP:0005938)	4.29560683
16	Hypoplastic ischia (HP:0003175)	4.28679674
17	Infertility (HP:0000789)	4.19185923
18	Tubulointerstitial nephritis (HP:0001970)	4.08598131
19	Male infertility (HP:0003251)	4.06175350
20	Hyperkalemia (HP:0002153)	4.01817277
21	Facial shape deformation (HP:0011334)	4.00753735
22	Potter facies (HP:0002009)	4.00753735
23	Abnormality of macular pigmentation (HP:0008002)	3.93256367
24	Enlarged epiphyses (HP:0010580)	3.89621140
25	Azoospermia (HP:0000027)	3.82134027
26	Abnormality of the ischium (HP:0003174)	3.81790642
27	Unilateral renal agenesis (HP:0000122)	3.75171870
28	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.71263802
29	Abnormal spermatogenesis (HP:0008669)	3.67440022
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.61437507
31	Chronic hepatic failure (HP:0100626)	3.56582639
32	Abnormality of the nasal mucosa (HP:0000433)	3.55822295
33	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.46050784
34	Cone-rod dystrophy (HP:0000548)	3.28864343
35	Congenital malformation of the right heart (HP:0011723)	3.22115101
36	Double outlet right ventricle (HP:0001719)	3.22115101
37	Impulsivity (HP:0100710)	3.10980255
38	Hypoplasia of the thymus (HP:0000778)	2.99525596
39	Abnormality of the aortic arch (HP:0012303)	2.99005891
40	Renal dysplasia (HP:0000110)	2.84902581
41	Postural instability (HP:0002172)	2.82890289
42	Generalized aminoaciduria (HP:0002909)	2.78770522
43	Abnormal urine output (HP:0012590)	2.76957676
44	Progressive sensorineural hearing impairment (HP:0000408)	2.75781627
45	Rhinitis (HP:0012384)	2.54641383
46	Stage 5 chronic kidney disease (HP:0003774)	2.53606834
47	Hypoalphalipoproteinemia (HP:0003233)	2.49537182
48	Abnormality of the parathyroid morphology (HP:0011766)	2.48288081
49	Absent epiphyses (HP:0010577)	2.46590222
50	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.46590222
51	Ventricular tachycardia (HP:0004756)	2.46540396
52	Hyperthyroidism (HP:0000836)	2.43806300
53	Abnormality of potassium homeostasis (HP:0011042)	2.43288691
54	Abnormality of the costochondral junction (HP:0000919)	2.42042963
55	Flattened epiphyses (HP:0003071)	2.39256694
56	Epiphyseal dysplasia (HP:0002656)	2.38858876
57	Abnormality of renal excretion (HP:0011036)	2.37944671
58	Nephronophthisis (HP:0000090)	2.34540610
59	Amelogenesis imperfecta (HP:0000705)	2.33134490
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.31258577
61	Abnormality of dental color (HP:0011073)	2.24658261
62	Truncal obesity (HP:0001956)	2.20944203
63	Tetany (HP:0001281)	2.19715007
64	Spastic paraparesis (HP:0002313)	2.18767317
65	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.18715591
66	Progressive cerebellar ataxia (HP:0002073)	2.18046126
67	Polyuria (HP:0000103)	2.16512929
68	Polydipsia (HP:0001959)	2.16187335
69	Abnormal drinking behavior (HP:0030082)	2.16187335
70	Hypoparathyroidism (HP:0000829)	2.15078363
71	Hyponatremia (HP:0002902)	2.12646632
72	Insulin-resistant diabetes mellitus (HP:0000831)	2.11722012
73	Atelectasis (HP:0100750)	2.09810866
74	Abnormality of the pubic bones (HP:0003172)	2.09282251
75	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.04663874
76	Abnormality of femoral epiphyses (HP:0006499)	2.04663874
77	Abnormal ventriculo-arterial connection (HP:0011563)	2.02357707
78	Transposition of the great arteries (HP:0001669)	2.02357707
79	Abnormal connection of the cardiac segments (HP:0011545)	2.02357707
80	Sensory axonal neuropathy (HP:0003390)	2.02299758
81	Osteomalacia (HP:0002749)	2.02296580
82	Portal hypertension (HP:0001409)	2.01615923
83	Focal segmental glomerulosclerosis (HP:0000097)	1.97743752
84	Abnormality of the renal medulla (HP:0100957)	1.96248508
85	Renovascular hypertension (HP:0100817)	1.95644544
86	Bowel incontinence (HP:0002607)	1.95236203
87	Bronchiectasis (HP:0002110)	1.93873790
88	Abnormality of the femoral head (HP:0003368)	1.93704705
89	Widely patent fontanelles and sutures (HP:0004492)	1.92939700
90	Flat capital femoral epiphysis (HP:0003370)	1.92532670
91	Bradycardia (HP:0001662)	1.91044932
92	Recurrent corneal erosions (HP:0000495)	1.90280137
93	Tubulointerstitial abnormality (HP:0001969)	1.89020645
94	Decreased central vision (HP:0007663)	1.86017359
95	Short ribs (HP:0000773)	1.84829863
96	Abnormality of the hepatic vasculature (HP:0006707)	1.83090116
97	Amblyopia (HP:0000646)	1.82847977
98	Menstrual irregularities (HP:0000858)	1.82316407
99	Abnormal large intestine physiology (HP:0012700)	1.82235922
100	Hypophosphatemic rickets (HP:0004912)	1.82200786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.13567935
2	TESK1	6.92593103
3	DDR2	5.51792752
4	MAP4K2	4.07106293
5	INSRR	3.82756148
6	STK38	3.23114509
7	PLK2	2.94896883
8	BRD4	2.72938005
9	PNCK	2.50807438
10	MAPK15	2.38691082
11	PRKD3	2.16526293
12	STK38L	2.15192428
13	MST1R	2.10273181
14	CAMK1G	1.98805074
15	WNK1	1.91823409
16	PDPK1	1.62755755
17	PIK3CG	1.57173612
18	CDK7	1.46283041
19	PDK1	1.44405338
20	DYRK1B	1.30315986
21	CDK12	1.24943174
22	KSR2	1.22820020
23	MAP3K9	1.19804050
24	LATS2	1.14227009
25	PTK2B	1.11240645
26	NEK6	1.06638445
27	UHMK1	0.86259795
28	BRAF	0.75380116
29	PRKG2	0.73973552
30	CAMK1D	0.73284474
31	MAP3K2	0.72033948
32	RPS6KA2	0.70405382
33	MAP3K8	0.70024211
34	PRKAA2	0.69887639
35	MAP3K11	0.69653750
36	AKT3	0.69053061
37	MAP2K2	0.67927933
38	PRKG1	0.61625647
39	RPS6KA1	0.60550596
40	ROCK1	0.55890800
41	LATS1	0.55448768
42	WNK4	0.54897908
43	CDK4	0.52714878
44	CAMK1	0.51331309
45	MET	0.49614556
46	MUSK	0.47954743
47	SIK2	0.47909892
48	ARAF	0.47807803
49	TESK2	0.46136667
50	CDK3	0.44830341
51	GSK3B	0.43340871
52	CDK2	0.41574140
53	STK39	0.40379186
54	CDK1	0.40051242
55	MAPK1	0.38191270
56	MTOR	0.37123231
57	MAP3K1	0.36379411
58	RPS6KC1	0.35696554
59	RPS6KL1	0.35696554
60	BRSK1	0.33803768
61	BMPR1B	0.33679637
62	CAMK4	0.33514024
63	MAPK8	0.33126208
64	RPS6KA6	0.32181388
65	TYRO3	0.31969591
66	CHEK1	0.30413659
67	PRKCG	0.29985038
68	MARK1	0.28524394
69	SGK223	0.28054027
70	SGK494	0.28054027
71	PRKCZ	0.27639998
72	NTRK3	0.22455790
73	MAPK14	0.21698010
74	ABL2	0.21387971
75	MAPK10	0.19866922
76	SGK1	0.19307571
77	PRKCB	0.18030020
78	MAPK11	0.17135475
79	FER	0.17115252
80	MARK2	0.16238281
81	AKT1	0.15584027
82	TIE1	0.15246278
83	BLK	0.13661285
84	PKN1	0.12605182
85	IKBKB	0.09717453
86	DYRK3	0.09116447
87	OXSR1	0.08091859
88	CHUK	0.06348177
89	PRKACB	0.05852123
90	AURKA	0.05760732
91	PRKACA	0.05446494
92	MAPK9	0.05445278
93	CAMK2A	0.05154334
94	MAP2K1	0.04591443
95	PINK1	0.04539890
96	PAK2	0.04383493
97	MAP3K7	0.04317928
98	ROCK2	0.03995736
99	MAP3K4	0.03351885
100	PRKAA1	0.02811190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.83709606
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.62464974
3	Olfactory transduction_Homo sapiens_hsa04740	3.68434229
4	Butanoate metabolism_Homo sapiens_hsa00650	2.85673704
5	Allograft rejection_Homo sapiens_hsa05330	2.28214557
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.22436420
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17900529
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.08795388
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.03357247
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.92728028
11	Phenylalanine metabolism_Homo sapiens_hsa00360	1.84869251
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.67459721
13	Viral myocarditis_Homo sapiens_hsa05416	1.67449868
14	Taste transduction_Homo sapiens_hsa04742	1.64933160
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.63678283
16	Type II diabetes mellitus_Homo sapiens_hsa04930	1.52326797
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.49545936
18	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45879071
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.43876738
20	Fatty acid degradation_Homo sapiens_hsa00071	1.42699410
21	RNA transport_Homo sapiens_hsa03013	1.37469750
22	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.37202880
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.30306614
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.29463026
25	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.26690467
26	Endocytosis_Homo sapiens_hsa04144	1.23800846
27	Protein digestion and absorption_Homo sapiens_hsa04974	1.06661635
28	Arginine biosynthesis_Homo sapiens_hsa00220	0.99824672
29	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.98888511
30	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97921345
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97847942
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96299377
33	Salivary secretion_Homo sapiens_hsa04970	0.93858739
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87988269
35	Influenza A_Homo sapiens_hsa05164	0.87630549
36	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84771970
37	Phototransduction_Homo sapiens_hsa04744	0.84503773
38	Oocyte meiosis_Homo sapiens_hsa04114	0.83919680
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.83256273
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.77491931
41	PPAR signaling pathway_Homo sapiens_hsa03320	0.74988797
42	cAMP signaling pathway_Homo sapiens_hsa04024	0.74756553
43	Renin-angiotensin system_Homo sapiens_hsa04614	0.74180234
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.72929894
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70344810
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.69904544
47	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.66717677
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.66670041
49	Morphine addiction_Homo sapiens_hsa05032	0.64799034
50	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63591795
51	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58164847
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55786360
53	Retinol metabolism_Homo sapiens_hsa00830	0.54581831
54	Purine metabolism_Homo sapiens_hsa00230	0.54012046
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51319827
56	ABC transporters_Homo sapiens_hsa02010	0.50099925
57	Circadian entrainment_Homo sapiens_hsa04713	0.50039163
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48515484
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45657967
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43868512
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.42629622
62	Nicotine addiction_Homo sapiens_hsa05033	0.41515424
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.41452719
64	VEGF signaling pathway_Homo sapiens_hsa04370	0.41118011
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.40855705
66	Tight junction_Homo sapiens_hsa04530	0.39676371
67	Bile secretion_Homo sapiens_hsa04976	0.39372240
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38676781
69	Renin secretion_Homo sapiens_hsa04924	0.38309105
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38081297
71	Viral carcinogenesis_Homo sapiens_hsa05203	0.37446491
72	Insulin secretion_Homo sapiens_hsa04911	0.34837941
73	Gastric acid secretion_Homo sapiens_hsa04971	0.34765417
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33209877
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33127443
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.32698427
77	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31353491
78	Basal transcription factors_Homo sapiens_hsa03022	0.29381450
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27940174
80	ECM-receptor interaction_Homo sapiens_hsa04512	0.27624505
81	Herpes simplex infection_Homo sapiens_hsa05168	0.26476961
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26387841
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.26067244
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24272182
85	Legionellosis_Homo sapiens_hsa05134	0.22087136
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.19894315
87	Huntingtons disease_Homo sapiens_hsa05016	0.19528555
88	Cholinergic synapse_Homo sapiens_hsa04725	0.19343449
89	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.17944259
90	Pancreatic secretion_Homo sapiens_hsa04972	0.17828946
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.17705556
92	Toxoplasmosis_Homo sapiens_hsa05145	0.17331713
93	Serotonergic synapse_Homo sapiens_hsa04726	0.15981392
94	Prolactin signaling pathway_Homo sapiens_hsa04917	0.15509987
95	Fanconi anemia pathway_Homo sapiens_hsa03460	0.14530571
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.13787500
97	Adherens junction_Homo sapiens_hsa04520	0.13611538
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.13262857
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.13189240
100	Metabolic pathways_Homo sapiens_hsa01100	0.13176629

C20ORF141

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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