ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.65540612
2	behavioral response to nicotine (GO:0035095)	5.64243642
3	rRNA methylation (GO:0031167)	5.32435022
4	sperm motility (GO:0030317)	5.13278719
5	acrosome reaction (GO:0007340)	4.89619692
6	detection of light stimulus involved in sensory perception (GO:0050962)	4.81019134
7	detection of light stimulus involved in visual perception (GO:0050908)	4.81019134
8	cellular ketone body metabolic process (GO:0046950)	4.78876759
9	rRNA modification (GO:0000154)	4.72927172
10	ketone body metabolic process (GO:1902224)	4.22007492
11	protein polyglutamylation (GO:0018095)	4.12772678
12	regulation of cilium movement (GO:0003352)	4.01481412
13	multicellular organism reproduction (GO:0032504)	3.97628184
14	nephron epithelium morphogenesis (GO:0072088)	3.89281004
15	nephron tubule morphogenesis (GO:0072078)	3.89281004
16	spermatid development (GO:0007286)	3.87048704
17	microtubule depolymerization (GO:0007019)	3.84460378
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.83473317
19	meiotic chromosome segregation (GO:0045132)	3.81113822
20	L-fucose catabolic process (GO:0042355)	3.74580235
21	fucose catabolic process (GO:0019317)	3.74580235
22	L-fucose metabolic process (GO:0042354)	3.74580235
23	cilium or flagellum-dependent cell motility (GO:0001539)	3.65404784
24	cellular response to ATP (GO:0071318)	3.58873846
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57733694
26	DNA deamination (GO:0045006)	3.51913926
27	single strand break repair (GO:0000012)	3.46534612
28	epithelial cilium movement (GO:0003351)	3.45348371
29	establishment of protein localization to Golgi (GO:0072600)	3.33220303
30	piRNA metabolic process (GO:0034587)	3.30905697
31	protein localization to Golgi apparatus (GO:0034067)	3.29139340
32	indolalkylamine metabolic process (GO:0006586)	3.27457563
33	nonmotile primary cilium assembly (GO:0035058)	3.23811856
34	motile cilium assembly (GO:0044458)	3.23072075
35	tryptophan catabolic process (GO:0006569)	3.21199825
36	indole-containing compound catabolic process (GO:0042436)	3.21199825
37	indolalkylamine catabolic process (GO:0046218)	3.21199825
38	spinal cord motor neuron differentiation (GO:0021522)	3.19382926
39	protein targeting to Golgi (GO:0000042)	3.14791376
40	DNA strand renaturation (GO:0000733)	3.12241582
41	fusion of sperm to egg plasma membrane (GO:0007342)	3.11492147
42	sperm-egg recognition (GO:0035036)	3.08091899
43	axonemal dynein complex assembly (GO:0070286)	3.07319882
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.06857388
45	microtubule polymerization or depolymerization (GO:0031109)	3.06156951
46	organic cation transport (GO:0015695)	3.03531768
47	centriole replication (GO:0007099)	3.02047515
48	tryptophan metabolic process (GO:0006568)	2.99830948
49	coenzyme catabolic process (GO:0009109)	2.98308912
50	reproduction (GO:0000003)	2.97958179
51	axoneme assembly (GO:0035082)	2.97901939
52	tRNA modification (GO:0006400)	2.97334852
53	cornea development in camera-type eye (GO:0061303)	2.94651257
54	male meiosis I (GO:0007141)	2.92262356
55	calcium ion-dependent exocytosis (GO:0017156)	2.91783327
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.91325154
57	phosphatidylethanolamine metabolic process (GO:0046337)	2.91142527
58	cilium movement (GO:0003341)	2.88030402
59	neuronal action potential (GO:0019228)	2.88008343
60	regulation of action potential (GO:0098900)	2.87180207
61	microtubule severing (GO:0051013)	2.86846326
62	RNA destabilization (GO:0050779)	2.86061061
63	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.84580910
64	regulation of microtubule-based movement (GO:0060632)	2.82458006
65	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80788216
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80788216
67	NADH dehydrogenase complex assembly (GO:0010257)	2.80788216
68	primary amino compound metabolic process (GO:1901160)	2.80474539
69	reciprocal meiotic recombination (GO:0007131)	2.80381733
70	reciprocal DNA recombination (GO:0035825)	2.80381733
71	sperm capacitation (GO:0048240)	2.77333678
72	kynurenine metabolic process (GO:0070189)	2.76424893
73	renal tubule morphogenesis (GO:0061333)	2.75356653
74	protein K11-linked deubiquitination (GO:0035871)	2.74719386
75	cilium organization (GO:0044782)	2.74469899
76	protein complex biogenesis (GO:0070271)	2.72426887
77	mannosylation (GO:0097502)	2.69502431
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.69410755
79	urinary tract smooth muscle contraction (GO:0014848)	2.69005665
80	male gamete generation (GO:0048232)	2.68901415
81	spermatogenesis (GO:0007283)	2.68665856
82	seminiferous tubule development (GO:0072520)	2.68573471
83	basic amino acid transport (GO:0015802)	2.67913565
84	DNA methylation involved in gamete generation (GO:0043046)	2.65568875
85	cilium assembly (GO:0042384)	2.65359918
86	photoreceptor cell development (GO:0042461)	2.65251189
87	centriole assembly (GO:0098534)	2.64781907
88	pseudouridine synthesis (GO:0001522)	2.61366667
89	regulation of centriole replication (GO:0046599)	2.61334433
90	protein-cofactor linkage (GO:0018065)	2.58450329
91	nucleotide transmembrane transport (GO:1901679)	2.57479925
92	respiratory chain complex IV assembly (GO:0008535)	2.57172561
93	negative regulation of cell aging (GO:0090344)	2.56913416
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56066734
95	cellular biogenic amine catabolic process (GO:0042402)	2.54648998
96	amine catabolic process (GO:0009310)	2.54648998
97	cell-cell recognition (GO:0009988)	2.54393192
98	sulfation (GO:0051923)	2.53885952
99	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53620966
100	positive regulation of mitochondrial fission (GO:0090141)	2.51785004

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45110595
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.39894693
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16020301
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.52556179
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42906275
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.28973102
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.18060915
8	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.15350512
9	FUS_26573619_Chip-Seq_HEK293_Human	2.10684725
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.04872147
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04441300
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.04097463
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98742344
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96418089
15	ERA_21632823_ChIP-Seq_H3396_Human	1.89204296
16	TP53_22573176_ChIP-Seq_HFKS_Human	1.77559614
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71139683
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71139683
19	EWS_26573619_Chip-Seq_HEK293_Human	1.70959866
20	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.70356268
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68504141
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.68504141
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60837721
24	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60015668
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.57608629
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57442567
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55597551
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.55445690
29	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.50893547
30	P300_19829295_ChIP-Seq_ESCs_Human	1.50481228
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.50348089
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49094775
33	MYC_19829295_ChIP-Seq_ESCs_Human	1.48166683
34	P53_21459846_ChIP-Seq_SAOS-2_Human	1.47757811
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.47600801
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44228681
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42971400
38	E2F1_20622854_ChIP-Seq_HELA_Human	1.42919620
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41216655
40	NCOR_22424771_ChIP-Seq_293T_Human	1.40610863
41	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.38987837
42	RAC3_21632823_ChIP-Seq_H3396_Human	1.37074632
43	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.36689657
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36125231
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35404348
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.34943508
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34599892
48	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32318521
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.30842982
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30548736
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30548736
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.29986883
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29555691
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.27649338
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26010511
56	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.24453358
57	STAT3_23295773_ChIP-Seq_U87_Human	1.23425101
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22893522
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.22558566
60	PHF8_20622854_ChIP-Seq_HELA_Human	1.22186452
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.21529376
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18853645
63	AR_25329375_ChIP-Seq_VCAP_Human	1.18756979
64	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18747701
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18331938
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18128140
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17514405
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17418503
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17418503
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.17146467
71	DROSHA_22980978_ChIP-Seq_HELA_Human	1.13896174
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.13851856
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.13837323
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13532293
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12929597
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10683177
77	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.10402880
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10283938
79	CTCF_27219007_Chip-Seq_Bcells_Human	1.10217336
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.08596976
81	TCF4_23295773_ChIP-Seq_U87_Human	1.08348755
82	AR_20517297_ChIP-Seq_VCAP_Human	1.06547638
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05785875
84	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05039589
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05025731
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04194231
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03910878
88	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03502461
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03196349
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02387171
91	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02354640
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02332742
93	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01555971
94	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01093851
95	ERG_20517297_ChIP-Seq_VCAP_Human	1.00695559
96	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99430145
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98835902
98	P68_20966046_ChIP-Seq_HELA_Human	0.97801796
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97647746
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96909190

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.65285397
2	MP0005174_abnormal_tail_pigmentation	3.21018758
3	MP0001986_abnormal_taste_sensitivity	3.18131927
4	MP0003136_yellow_coat_color	2.94801305
5	MP0005423_abnormal_somatic_nervous	2.92926544
6	MP0000569_abnormal_digit_pigmentation	2.91318186
7	MP0001968_abnormal_touch/_nociception	2.77700838
8	MP0005551_abnormal_eye_electrophysiolog	2.71107399
9	MP0006292_abnormal_olfactory_placode	2.48685389
10	MP0008877_abnormal_DNA_methylation	2.41512370
11	MP0005377_hearing/vestibular/ear_phenot	2.41182518
12	MP0003878_abnormal_ear_physiology	2.41182518
13	MP0005171_absent_coat_pigmentation	2.33556026
14	MP0002736_abnormal_nociception_after	2.12413034
15	MP0002837_dystrophic_cardiac_calcinosis	2.06176468
16	MP0002653_abnormal_ependyma_morphology	1.93169925
17	MP0002876_abnormal_thyroid_physiology	1.87894052
18	MP0002638_abnormal_pupillary_reflex	1.83354832
19	MP0005645_abnormal_hypothalamus_physiol	1.82261125
20	MP0003195_calcinosis	1.76541105
21	MP0003698_abnormal_male_reproductive	1.75045960
22	MP0003718_maternal_effect	1.71668762
23	MP0002102_abnormal_ear_morphology	1.69849582
24	MP0005253_abnormal_eye_physiology	1.67470166
25	MP0003646_muscle_fatigue	1.60505479
26	MP0005083_abnormal_biliary_tract	1.60419930
27	MP0008875_abnormal_xenobiotic_pharmacok	1.59363685
28	MP0001929_abnormal_gametogenesis	1.59310088
29	MP0005360_urolithiasis	1.58375593
30	MP0006072_abnormal_retinal_apoptosis	1.49197931
31	MP0001984_abnormal_olfaction	1.45406655
32	MP0003011_delayed_dark_adaptation	1.43912024
33	MP0000015_abnormal_ear_pigmentation	1.42280134
34	MP0001485_abnormal_pinna_reflex	1.40115446
35	MP0005379_endocrine/exocrine_gland_phen	1.39375939
36	MP0002928_abnormal_bile_duct	1.38133017
37	MP0000427_abnormal_hair_cycle	1.35633698
38	MP0009745_abnormal_behavioral_response	1.35255843
39	MP0006276_abnormal_autonomic_nervous	1.34828635
40	MP0002138_abnormal_hepatobiliary_system	1.33926362
41	MP0004043_abnormal_pH_regulation	1.32429472
42	MP0002160_abnormal_reproductive_system	1.31944288
43	MP0003787_abnormal_imprinting	1.31575327
44	MP0001486_abnormal_startle_reflex	1.30754776
45	MP0002272_abnormal_nervous_system	1.29934079
46	MP0005084_abnormal_gallbladder_morpholo	1.25696369
47	MP0004142_abnormal_muscle_tone	1.25273981
48	MP0002735_abnormal_chemical_nociception	1.22626616
49	MP0001970_abnormal_pain_threshold	1.21771792
50	MP0001529_abnormal_vocalization	1.20381843
51	MP0004885_abnormal_endolymph	1.19776521
52	MP0002938_white_spotting	1.19472726
53	MP0002572_abnormal_emotion/affect_behav	1.19064074
54	MP0000631_abnormal_neuroendocrine_gland	1.18726076
55	MP0004742_abnormal_vestibular_system	1.18122819
56	MP0005646_abnormal_pituitary_gland	1.16143261
57	MP0009046_muscle_twitch	1.15832158
58	MP0005670_abnormal_white_adipose	1.15676127
59	MP0001502_abnormal_circadian_rhythm	1.13296297
60	MP0001905_abnormal_dopamine_level	1.12988890
61	MP0005332_abnormal_amino_acid	1.12073106
62	MP0002210_abnormal_sex_determination	1.11804772
63	MP0002557_abnormal_social/conspecific_i	1.09162199
64	MP0001188_hyperpigmentation	1.06000747
65	MP0008789_abnormal_olfactory_epithelium	1.05853221
66	MP0008872_abnormal_physiological_respon	1.05608674
67	MP0005389_reproductive_system_phenotype	1.05114582
68	MP0001919_abnormal_reproductive_system	1.04823790
69	MP0002733_abnormal_thermal_nociception	1.04594909
70	MP0005386_behavior/neurological_phenoty	1.02867795
71	MP0004924_abnormal_behavior	1.02867795
72	MP0003137_abnormal_impulse_conducting	1.02847650
73	MP0002909_abnormal_adrenal_gland	1.02426304
74	MP0010386_abnormal_urinary_bladder	1.02097412
75	MP0004133_heterotaxia	1.01530578
76	MP0000026_abnormal_inner_ear	1.01411438
77	MP0004147_increased_porphyrin_level	1.00865342
78	MP0002095_abnormal_skin_pigmentation	0.98172826
79	MP0008995_early_reproductive_senescence	0.96401575
80	MP0001501_abnormal_sleep_pattern	0.95589183
81	MP0000372_irregular_coat_pigmentation	0.93596359
82	MP0005195_abnormal_posterior_eye	0.93015636
83	MP0001963_abnormal_hearing_physiology	0.92257752
84	MP0000538_abnormal_urinary_bladder	0.90577243
85	MP0001324_abnormal_eye_pigmentation	0.90431109
86	MP0002163_abnormal_gland_morphology	0.87846471
87	MP0002067_abnormal_sensory_capabilities	0.87005128
88	MP0001756_abnormal_urination	0.86551660
89	MP0000653_abnormal_sex_gland	0.85502107
90	MP0001145_abnormal_male_reproductive	0.85050500
91	MP0002229_neurodegeneration	0.82049924
92	MP0001765_abnormal_ion_homeostasis	0.81249555
93	MP0002161_abnormal_fertility/fecundity	0.80876887
94	MP0002064_seizures	0.79789792
95	MP0003635_abnormal_synaptic_transmissio	0.77144542
96	MP0002234_abnormal_pharynx_morphology	0.76829504
97	MP0004085_abnormal_heartbeat	0.76826944
98	MP0002063_abnormal_learning/memory/cond	0.76761270
99	MP0004215_abnormal_myocardial_fiber	0.76621610
100	MP0002254_reproductive_system_inflammat	0.74571564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	5.15088924
2	Congenital stationary night blindness (HP:0007642)	4.63387806
3	Bony spicule pigmentary retinopathy (HP:0007737)	4.10156836
4	Nephronophthisis (HP:0000090)	3.97239644
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.90279836
6	Absent/shortened dynein arms (HP:0200106)	3.90279836
7	Abnormality of midbrain morphology (HP:0002418)	3.64072661
8	Molar tooth sign on MRI (HP:0002419)	3.64072661
9	Abnormal drinking behavior (HP:0030082)	3.58174699
10	Polydipsia (HP:0001959)	3.58174699
11	Pancreatic cysts (HP:0001737)	3.51423088
12	Tubular atrophy (HP:0000092)	3.39156476
13	Abnormality of the renal medulla (HP:0100957)	3.31438887
14	Chronic hepatic failure (HP:0100626)	3.27187335
15	Pancreatic fibrosis (HP:0100732)	3.19704624
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.18378342
17	Decreased central vision (HP:0007663)	2.99596979
18	Pendular nystagmus (HP:0012043)	2.97399121
19	Hypoplasia of the pons (HP:0012110)	2.96685504
20	Polyuria (HP:0000103)	2.90110391
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87759562
22	Abnormality of alanine metabolism (HP:0010916)	2.87759562
23	Hyperalaninemia (HP:0003348)	2.87759562
24	Abnormality of the renal cortex (HP:0011035)	2.85459288
25	Rib fusion (HP:0000902)	2.84143027
26	True hermaphroditism (HP:0010459)	2.74103504
27	Abnormality of the pons (HP:0007361)	2.73902884
28	Medial flaring of the eyebrow (HP:0010747)	2.72591583
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.72571720
30	Severe visual impairment (HP:0001141)	2.62773292
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.61753868
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.61753868
33	Abnormal ciliary motility (HP:0012262)	2.58599665
34	Chorioretinal atrophy (HP:0000533)	2.57877406
35	Cerebellar dysplasia (HP:0007033)	2.57750976
36	Type II lissencephaly (HP:0007260)	2.55515174
37	Decreased circulating renin level (HP:0003351)	2.55197503
38	Hyperventilation (HP:0002883)	2.53253415
39	Abnormal urine output (HP:0012590)	2.51598369
40	Abolished electroretinogram (ERG) (HP:0000550)	2.31897649
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31299327
42	Patellar aplasia (HP:0006443)	2.31033083
43	Hypoalbuminemia (HP:0003073)	2.24408168
44	Abnormal albumin level (HP:0012116)	2.24408168
45	Abnormality of renal excretion (HP:0011036)	2.18593179
46	Absent thumb (HP:0009777)	2.17350553
47	Cystic liver disease (HP:0006706)	2.16715084
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.11803555
49	Congenital hepatic fibrosis (HP:0002612)	2.06805232
50	Progressive cerebellar ataxia (HP:0002073)	2.04018103
51	Gait imbalance (HP:0002141)	2.00989309
52	Gaze-evoked nystagmus (HP:0000640)	1.97428049
53	Abnormality of macular pigmentation (HP:0008002)	1.93388665
54	Increased CSF lactate (HP:0002490)	1.92414297
55	Methylmalonic aciduria (HP:0012120)	1.92094632
56	Congenital primary aphakia (HP:0007707)	1.91412625
57	Tachypnea (HP:0002789)	1.88730582
58	Enlarged epiphyses (HP:0010580)	1.87703378
59	Generalized aminoaciduria (HP:0002909)	1.87431294
60	Severe muscular hypotonia (HP:0006829)	1.86991129
61	Abnormality of the labia minora (HP:0012880)	1.85068847
62	Ketosis (HP:0001946)	1.84232847
63	Ketoacidosis (HP:0001993)	1.82990693
64	Rectal fistula (HP:0100590)	1.81729959
65	Rectovaginal fistula (HP:0000143)	1.81729959
66	Tubulointerstitial nephritis (HP:0001970)	1.81192593
67	Optic disc pallor (HP:0000543)	1.80174340
68	Abnormality of dental color (HP:0011073)	1.77476250
69	Mitochondrial inheritance (HP:0001427)	1.77318530
70	Lipid accumulation in hepatocytes (HP:0006561)	1.76274467
71	Inability to walk (HP:0002540)	1.76143600
72	Nephrogenic diabetes insipidus (HP:0009806)	1.76072087
73	Congenital sensorineural hearing impairment (HP:0008527)	1.73171769
74	Methylmalonic acidemia (HP:0002912)	1.72943517
75	Small hand (HP:0200055)	1.71418805
76	Progressive microcephaly (HP:0000253)	1.70765227
77	Anencephaly (HP:0002323)	1.69288971
78	Testicular atrophy (HP:0000029)	1.67492990
79	Azoospermia (HP:0000027)	1.66382907
80	Sclerocornea (HP:0000647)	1.66381218
81	Birth length less than 3rd percentile (HP:0003561)	1.64935862
82	Photophobia (HP:0000613)	1.64779533
83	Bilateral microphthalmos (HP:0007633)	1.64057793
84	Hepatic necrosis (HP:0002605)	1.63122279
85	Genital tract atresia (HP:0001827)	1.62872632
86	Failure to thrive in infancy (HP:0001531)	1.62284847
87	Renal cortical cysts (HP:0000803)	1.61985845
88	Mesangial abnormality (HP:0001966)	1.61783644
89	Neonatal respiratory distress (HP:0002643)	1.61697283
90	Glycosuria (HP:0003076)	1.61016525
91	Abnormality of urine glucose concentration (HP:0011016)	1.61016525
92	Protruding tongue (HP:0010808)	1.60943656
93	Keratoconus (HP:0000563)	1.60244178
94	Increased corneal curvature (HP:0100692)	1.60244178
95	Optic nerve hypoplasia (HP:0000609)	1.59341243
96	Abnormality of the nasal septum (HP:0000419)	1.59051146
97	Hepatocellular necrosis (HP:0001404)	1.58196388
98	Male pseudohermaphroditism (HP:0000037)	1.57853740
99	Squamous cell carcinoma (HP:0002860)	1.57772002
100	Vaginal atresia (HP:0000148)	1.57219800

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.73665761
2	WNK4	3.60897233
3	TLK1	3.58125673
4	ZAK	3.56544672
5	ADRBK2	3.22253322
6	PLK4	2.87879427
7	MAPK15	2.84410413
8	MAP4K2	2.58772973
9	BMPR1B	2.49533834
10	GRK1	2.29659962
11	INSRR	2.28336268
12	WNK3	1.93397759
13	PINK1	1.84976372
14	DAPK2	1.80665928
15	MAPK13	1.76952382
16	MAP3K4	1.70810482
17	TRIM28	1.70569023
18	NUAK1	1.67703794
19	STK39	1.41346227
20	TNIK	1.40018165
21	PDK2	1.38462491
22	ACVR1B	1.33466304
23	MUSK	1.28350651
24	OXSR1	1.27553974
25	CAMK1D	1.22772028
26	CASK	1.22225512
27	PNCK	1.20426181
28	BLK	1.12136654
29	MAP2K7	1.11640248
30	PLK2	1.09840250
31	CAMK1G	1.04081991
32	ADRBK1	1.03385382
33	TAOK3	1.01547703
34	VRK1	0.98708397
35	STK16	0.96995931
36	PHKG2	0.96474693
37	PHKG1	0.96474693
38	MARK1	0.96046897
39	AKT3	0.91980236
40	PTK2B	0.91916497
41	PRKCG	0.91150976
42	MAP2K6	0.89734295
43	MKNK2	0.89408043
44	PKN1	0.89095729
45	DYRK2	0.86869629
46	PRKD3	0.79055641
47	CAMKK2	0.78061846
48	RPS6KA5	0.77694605
49	TXK	0.74968614
50	WNK1	0.73266614
51	PAK3	0.71480076
52	CAMK1	0.70756085
53	MAP2K2	0.70258558
54	FGFR2	0.67245577
55	CCNB1	0.65329359
56	SIK2	0.64683592
57	TIE1	0.64381859
58	PRKCE	0.63348792
59	PRKAA1	0.61383634
60	CSNK1G3	0.58206160
61	PRKAA2	0.57700486
62	IKBKB	0.56570030
63	STK38L	0.55345904
64	CSNK1G2	0.55265897
65	ATR	0.53599942
66	PIK3CA	0.53309565
67	TAF1	0.53137022
68	CHEK2	0.52918319
69	NME1	0.52742832
70	RPS6KA6	0.50683836
71	CSNK1G1	0.49341130
72	CSNK1A1L	0.47815613
73	PRKCZ	0.47782384
74	PRKACA	0.47334520
75	STK11	0.45937861
76	CSNK1D	0.45439203
77	TGFBR1	0.45308805
78	BRSK2	0.44384268
79	STK38	0.43571649
80	IRAK1	0.43144847
81	CAMK4	0.42297318
82	GRK6	0.39891777
83	PRKCI	0.39725180
84	CAMK2A	0.39485182
85	NEK2	0.38509106
86	PLK1	0.37593302
87	PRKG1	0.36455727
88	NTRK3	0.36287834
89	MAP2K4	0.36134649
90	CDK3	0.35158610
91	EPHA3	0.35031735
92	MAPKAPK5	0.34725186
93	PIM2	0.34002013
94	PIK3CG	0.33541084
95	TSSK6	0.33370942
96	NTRK2	0.32363365
97	FLT3	0.31610597
98	CHUK	0.29722864
99	BCKDK	0.29212570
100	PRKCQ	0.28760373

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.11799260
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.07541203
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.01520962
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.99722798
5	Sulfur relay system_Homo sapiens_hsa04122	2.79899746
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.56645803
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.39963244
8	Butanoate metabolism_Homo sapiens_hsa00650	2.33982373
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33482400
10	Phototransduction_Homo sapiens_hsa04744	2.33294134
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27912182
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12215999
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.04787872
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99617476
15	Nicotine addiction_Homo sapiens_hsa05033	1.92153266
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.91628425
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.86901003
18	Olfactory transduction_Homo sapiens_hsa04740	1.81317573
19	Taste transduction_Homo sapiens_hsa04742	1.79367943
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73024670
21	Homologous recombination_Homo sapiens_hsa03440	1.69634821
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.62231760
23	Basal transcription factors_Homo sapiens_hsa03022	1.58312500
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.53497592
25	Parkinsons disease_Homo sapiens_hsa05012	1.47107604
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42709165
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.42130656
28	RNA polymerase_Homo sapiens_hsa03020	1.29481841
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22519176
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19053233
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18372004
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14894550
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.13591710
34	Propanoate metabolism_Homo sapiens_hsa00640	1.13473744
35	Huntingtons disease_Homo sapiens_hsa05016	1.13264078
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11638328
37	ABC transporters_Homo sapiens_hsa02010	1.07769094
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.06308344
39	Insulin secretion_Homo sapiens_hsa04911	1.01320142
40	Morphine addiction_Homo sapiens_hsa05032	1.00741250
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99785752
42	Peroxisome_Homo sapiens_hsa04146	0.97165373
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.95124937
44	One carbon pool by folate_Homo sapiens_hsa00670	0.91770474
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91335275
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89082275
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88051545
48	RNA degradation_Homo sapiens_hsa03018	0.85638826
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85531180
50	Alzheimers disease_Homo sapiens_hsa05010	0.85089793
51	Sulfur metabolism_Homo sapiens_hsa00920	0.84250229
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84055733
53	Retinol metabolism_Homo sapiens_hsa00830	0.83983382
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83315239
55	Mineral absorption_Homo sapiens_hsa04978	0.82136419
56	Fatty acid degradation_Homo sapiens_hsa00071	0.81313231
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78506839
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75271334
59	Purine metabolism_Homo sapiens_hsa00230	0.74907941
60	Protein export_Homo sapiens_hsa03060	0.73729483
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.72788768
62	Metabolic pathways_Homo sapiens_hsa01100	0.72394450
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70671376
64	Serotonergic synapse_Homo sapiens_hsa04726	0.69454668
65	Caffeine metabolism_Homo sapiens_hsa00232	0.66477573
66	Lysine degradation_Homo sapiens_hsa00310	0.65020184
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64988691
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64870217
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64215323
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64001258
71	Cocaine addiction_Homo sapiens_hsa05030	0.63022605
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61739212
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61723172
74	Circadian entrainment_Homo sapiens_hsa04713	0.61620967
75	Histidine metabolism_Homo sapiens_hsa00340	0.60928460
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.60639133
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60488746
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59731611
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55585444
80	GABAergic synapse_Homo sapiens_hsa04727	0.54211412
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.52567765
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52252645
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.51553228
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51424486
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.50914712
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50092643
87	RNA transport_Homo sapiens_hsa03013	0.49945148
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.48667264
89	Regulation of autophagy_Homo sapiens_hsa04140	0.42663691
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42613107
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42355076
92	Salivary secretion_Homo sapiens_hsa04970	0.42064690
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41889008
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41068959
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.39258754
96	Alcoholism_Homo sapiens_hsa05034	0.39134101
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37702151
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.34848134
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32636806
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.32610817

C20ORF144

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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