C20ORF173

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.55710963
2sperm capacitation (GO:0048240)9.27914387
3response to pheromone (GO:0019236)9.25159612
4DNA packaging (GO:0006323)9.18315268
5single strand break repair (GO:0000012)8.61282376
6plasma membrane fusion (GO:0045026)8.41311006
7spermatid nucleus differentiation (GO:0007289)8.32706331
8microtubule depolymerization (GO:0007019)8.12366082
9spermatid development (GO:0007286)8.04064585
10sperm-egg recognition (GO:0035036)7.42946194
11rRNA methylation (GO:0031167)7.20594642
12sexual reproduction (GO:0019953)7.05990998
13multicellular organism reproduction (GO:0032504)6.99564288
14binding of sperm to zona pellucida (GO:0007339)6.86346028
15protein targeting to Golgi (GO:0000042)6.79211329
16protein polyglutamylation (GO:0018095)6.77786874
17reproduction (GO:0000003)6.76788455
18microtubule polymerization or depolymerization (GO:0031109)6.75244155
19calcium ion-dependent exocytosis (GO:0017156)6.64857434
20negative regulation of inclusion body assembly (GO:0090084)6.55128725
21establishment of protein localization to Golgi (GO:0072600)6.53506749
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.39271332
23retrograde transport, vesicle recycling within Golgi (GO:0000301)6.37633177
24spermatogenesis (GO:0007283)6.14539015
25male gamete generation (GO:0048232)6.12469415
26cell-cell recognition (GO:0009988)6.10284969
27axonemal dynein complex assembly (GO:0070286)6.08862081
28rRNA modification (GO:0000154)6.06375577
29phosphatidylethanolamine metabolic process (GO:0046337)5.92459983
30microtubule severing (GO:0051013)5.63817712
31cellular ketone body metabolic process (GO:0046950)5.63089593
32gamete generation (GO:0007276)5.60692332
33centriole replication (GO:0007099)5.46013912
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33375135
35positive regulation of Rab GTPase activity (GO:0032851)5.25507593
36regulation of Rab GTPase activity (GO:0032313)5.25507593
37regulation of cilium movement (GO:0003352)5.05536643
38single fertilization (GO:0007338)4.98956084
39chromatin silencing (GO:0006342)4.98178245
40ketone body metabolic process (GO:1902224)4.96275784
41motile cilium assembly (GO:0044458)4.92916165
42protein localization to Golgi apparatus (GO:0034067)4.90986232
43cilium or flagellum-dependent cell motility (GO:0001539)4.87458063
44centriole assembly (GO:0098534)4.85150878
45RNA destabilization (GO:0050779)4.70721356
46regulation of centriole replication (GO:0046599)4.69849243
47regulation of inclusion body assembly (GO:0090083)4.62139231
48germ cell development (GO:0007281)4.58874905
49regulation of transcription involved in cell fate commitment (GO:0060850)4.53596814
50multicellular organismal reproductive process (GO:0048609)4.48371710
51cell wall macromolecule catabolic process (GO:0016998)4.39383083
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.36025563
53seminiferous tubule development (GO:0072520)4.34237334
54cell wall macromolecule metabolic process (GO:0044036)4.23873084
55nucleus organization (GO:0006997)4.20699998
56fertilization (GO:0009566)4.15473172
57musculoskeletal movement (GO:0050881)4.03459082
58multicellular organismal movement (GO:0050879)4.03459082
59epithelial cilium movement (GO:0003351)3.96242797
60coenzyme catabolic process (GO:0009109)3.92514264
61glycerol ether metabolic process (GO:0006662)3.84147050
62negative regulation of Rho protein signal transduction (GO:0035024)3.73338472
63ether metabolic process (GO:0018904)3.53993200
64cilium movement (GO:0003341)3.51126073
65glomerular visceral epithelial cell development (GO:0072015)3.51052639
66organic cation transport (GO:0015695)3.44013153
67negative regulation of gene expression, epigenetic (GO:0045814)3.40810954
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38130328
69glomerular epithelial cell development (GO:0072310)3.36912170
70regulation of microtubule-based movement (GO:0060632)3.33137611
71nucleosome disassembly (GO:0006337)3.29623503
72protein-DNA complex disassembly (GO:0032986)3.29623503
73peptidyl-threonine dephosphorylation (GO:0035970)3.28788187
74microtubule nucleation (GO:0007020)3.20561916
75response to acidic pH (GO:0010447)3.20365550
76cerebral cortex neuron differentiation (GO:0021895)3.19724816
77regulation of interleukin-13 production (GO:0032656)3.17957468
78histone H3-K9 demethylation (GO:0033169)3.11744806
79cellular response to pH (GO:0071467)3.06111905
80regulation of T-helper 2 cell differentiation (GO:0045628)3.05719576
81protein depolymerization (GO:0051261)3.05549159
82polyamine biosynthetic process (GO:0006596)3.05142549
83homeostasis of number of cells within a tissue (GO:0048873)3.03667633
84multicellular organismal development (GO:0007275)3.00217525
85DNA conformation change (GO:0071103)2.98109351
86mesenchymal cell differentiation involved in renal system development (GO:2001012)2.97364933
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.97364933
88membrane protein intracellular domain proteolysis (GO:0031293)2.96967384
89cell recognition (GO:0008037)2.95136635
90cell differentiation involved in metanephros development (GO:0072202)2.87218035
91cranial nerve morphogenesis (GO:0021602)2.83164052
92NAD biosynthetic process (GO:0009435)2.82689070
93receptor recycling (GO:0001881)2.73704727
94regulation of ARF GTPase activity (GO:0032312)2.73176040
95metanephric tubule development (GO:0072170)2.71966617
96metanephric nephron tubule development (GO:0072234)2.71966617
97regulation of phosphoprotein phosphatase activity (GO:0043666)2.69952804
98acrosome reaction (GO:0007340)12.2350316
99sperm motility (GO:0030317)11.7866016
100fusion of sperm to egg plasma membrane (GO:0007342)11.0692113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.39945282
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09924580
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61644414
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34592859
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.34592859
6CBP_20019798_ChIP-Seq_JUKART_Human2.15154947
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.15154947
8EZH2_22144423_ChIP-Seq_EOC_Human2.10737128
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08619982
10CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99047106
11* ELF1_20517297_ChIP-Seq_JURKAT_Human1.95440563
12FUS_26573619_Chip-Seq_HEK293_Human1.95422703
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.95233802
14DROSHA_22980978_ChIP-Seq_HELA_Human1.93487306
15* ERA_21632823_ChIP-Seq_H3396_Human1.92314116
16EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.85606626
17* RAC3_21632823_ChIP-Seq_H3396_Human1.79448081
18CTCF_27219007_Chip-Seq_Bcells_Human1.78687033
19WDR5_24793694_ChIP-Seq_LNCAP_Human1.76847246
20* NANOG_20526341_ChIP-Seq_ESCs_Human1.72756242
21* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.72030654
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70548194
23* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68940986
24TAF2_19829295_ChIP-Seq_ESCs_Human1.67362123
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66408647
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66034594
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65965735
28* BCL6_27268052_Chip-Seq_Bcells_Human1.63674683
29SMC4_20622854_ChIP-Seq_HELA_Human1.62888719
30MYC_19829295_ChIP-Seq_ESCs_Human1.62380728
31BCOR_27268052_Chip-Seq_Bcells_Human1.61345506
32* E2F1_20622854_ChIP-Seq_HELA_Human1.60030345
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.59668383
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59657418
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.59619106
36ER_23166858_ChIP-Seq_MCF-7_Human1.58784402
37PHF8_20622854_ChIP-Seq_HELA_Human1.58597040
38* P68_20966046_ChIP-Seq_HELA_Human1.55036548
39OCT4_20526341_ChIP-Seq_ESCs_Human1.50826123
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50182321
41TP63_22573176_ChIP-Seq_HFKS_Human1.47568446
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47192481
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.46236955
44* CTCF_20526341_ChIP-Seq_ESCs_Human1.45266579
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43283887
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.43209326
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39835284
48AR_25329375_ChIP-Seq_VCAP_Human1.39435421
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39014580
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34870694
51TAF15_26573619_Chip-Seq_HEK293_Human1.33800124
52* LXR_22292898_ChIP-Seq_THP-1_Human1.32659250
53ERG_20517297_ChIP-Seq_VCAP_Human1.32575515
54TP53_18474530_ChIP-ChIP_U2OS_Human1.32457817
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31543681
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30795715
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.29327086
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.29127238
59* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28474812
60RBPJ_21746931_ChIP-Seq_IB4_Human1.26645228
61* P300_27268052_Chip-Seq_Bcells_Human1.25462416
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24742049
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.23625544
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21942723
65ETV1_20927104_ChIP-Seq_GIST48_Human1.21571656
66P53_21459846_ChIP-Seq_SAOS-2_Human1.21405158
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21034659
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20557598
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20388200
70CEBPB_22108803_ChIP-Seq_LS180_Human1.19560809
71* GATA3_21878914_ChIP-Seq_MCF-7_Human1.19496388
72P300_19829295_ChIP-Seq_ESCs_Human1.18807914
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17283748
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.15537494
75SA1_27219007_Chip-Seq_Bcells_Human1.15042525
76RUNX_20019798_ChIP-Seq_JUKART_Human1.13287706
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13018327
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12715232
79NFYB_21822215_ChIP-Seq_K562_Human1.12634203
80TBL1_22424771_ChIP-Seq_293T_Human1.12284750
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.11792769
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11513474
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.09796280
84SMRT_27268052_Chip-Seq_Bcells_Human1.09591941
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08099187
86ZNF274_21170338_ChIP-Seq_K562_Hela1.06399871
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06305272
88PHF8_20622853_ChIP-Seq_HELA_Human1.05956395
89AR_21572438_ChIP-Seq_LNCaP_Human1.05819310
90RUNX2_22187159_ChIP-Seq_PCA_Human1.03469809
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.01625983
92SOX2_19829295_ChIP-Seq_ESCs_Human0.99175376
93NANOG_19829295_ChIP-Seq_ESCs_Human0.99175376
94HOXB7_26014856_ChIP-Seq_BT474_Human0.99004357
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98506762
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.97843536
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.97567426
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97417482
99SMAD4_21799915_ChIP-Seq_A2780_Human0.96784447
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96506097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.06967937
2MP0005377_hearing/vestibular/ear_phenot5.06967937
3MP0003698_abnormal_male_reproductive4.40740264
4MP0005670_abnormal_white_adipose4.37999385
5MP0001348_abnormal_lacrimal_gland3.87168724
6MP0001929_abnormal_gametogenesis3.78851357
7MP0002161_abnormal_fertility/fecundity2.43782382
8MP0000678_abnormal_parathyroid_gland2.41166154
9MP0003011_delayed_dark_adaptation2.35318067
10MP0003718_maternal_effect2.05621223
11MP0005379_endocrine/exocrine_gland_phen2.03290053
12MP0005423_abnormal_somatic_nervous2.01188736
13MP0005410_abnormal_fertilization12.3479779
14MP0002132_abnormal_respiratory_system1.92480709
15MP0003646_muscle_fatigue1.85207314
16MP0002210_abnormal_sex_determination1.67071593
17MP0004742_abnormal_vestibular_system1.61403932
18MP0001486_abnormal_startle_reflex1.61127657
19MP0001968_abnormal_touch/_nociception1.48735454
20MP0001485_abnormal_pinna_reflex1.44576472
21MP0002249_abnormal_larynx_morphology1.44418928
22MP0002234_abnormal_pharynx_morphology1.42108538
23MP0002735_abnormal_chemical_nociception1.41635613
24MP0001145_abnormal_male_reproductive1.33669868
25MP0002282_abnormal_trachea_morphology1.33013978
26MP0004859_abnormal_synaptic_plasticity1.31465873
27MP0009053_abnormal_anal_canal1.31042399
28MP0005310_abnormal_salivary_gland1.28798477
29MP0004510_myositis1.28684238
30MP0001765_abnormal_ion_homeostasis1.27505038
31MP0000653_abnormal_sex_gland1.25998812
32MP0003879_abnormal_hair_cell1.24913033
33MP0002138_abnormal_hepatobiliary_system1.10604106
34MP0000534_abnormal_ureter_morphology1.09994732
35MP0001963_abnormal_hearing_physiology1.06632924
36MP0002822_catalepsy1.06291188
37MP0005451_abnormal_body_composition0.98691242
38MP0002127_abnormal_cardiovascular_syste0.98568387
39MP0008877_abnormal_DNA_methylation0.98029110
40MP0005248_abnormal_Harderian_gland0.97554104
41MP0000026_abnormal_inner_ear0.94292198
42MP0008569_lethality_at_weaning0.92589188
43MP0005551_abnormal_eye_electrophysiolog0.92151648
44MP0002067_abnormal_sensory_capabilities0.91029981
45MP0002229_neurodegeneration0.88652568
46MP0005083_abnormal_biliary_tract0.88340993
47MP0005395_other_phenotype0.88111602
48MP0002733_abnormal_thermal_nociception0.82521991
49MP0000955_abnormal_spinal_cord0.78896764
50MP0005666_abnormal_adipose_tissue0.76049997
51MP0009115_abnormal_fat_cell0.75874647
52MP0002557_abnormal_social/conspecific_i0.75668087
53MP0005253_abnormal_eye_physiology0.74900219
54MP0004085_abnormal_heartbeat0.74449058
55MP0003880_abnormal_central_pattern0.74116512
56MP0002272_abnormal_nervous_system0.73691434
57MP0000003_abnormal_adipose_tissue0.73578708
58MP0005375_adipose_tissue_phenotype0.70266469
59MP0000681_abnormal_thyroid_gland0.69861738
60MP0002572_abnormal_emotion/affect_behav0.68910895
61MP0001905_abnormal_dopamine_level0.68326339
62MP0005367_renal/urinary_system_phenotyp0.64826077
63MP0000516_abnormal_urinary_system0.64826077
64MP0001440_abnormal_grooming_behavior0.64118993
65MP0009745_abnormal_behavioral_response0.63919865
66MP0001984_abnormal_olfaction0.63531594
67MP0001970_abnormal_pain_threshold0.63186703
68MP0003137_abnormal_impulse_conducting0.62071447
69MP0004484_altered_response_of0.61639911
70MP0009046_muscle_twitch0.61616883
71MP0005636_abnormal_mineral_homeostasis0.61476747
72MP0005167_abnormal_blood-brain_barrier0.59031528
73MP0000049_abnormal_middle_ear0.57670929
74MP0003635_abnormal_synaptic_transmissio0.55710672
75MP0002734_abnormal_mechanical_nocicepti0.55503910
76MP0009697_abnormal_copulation0.54370984
77MP0005535_abnormal_body_temperature0.54018430
78MP0001501_abnormal_sleep_pattern0.52961621
79MP0001879_abnormal_lymphatic_vessel0.50219492
80MP0004036_abnormal_muscle_relaxation0.49789438
81MP0004233_abnormal_muscle_weight0.49771376
82MP0008995_early_reproductive_senescence0.47126179
83MP0005084_abnormal_gallbladder_morpholo0.44677297
84MP0000470_abnormal_stomach_morphology0.44052366
85MP0008961_abnormal_basal_metabolism0.43901672
86MP0003077_abnormal_cell_cycle0.43347881
87MP0002928_abnormal_bile_duct0.41958120
88MP0005623_abnormal_meninges_morphology0.39864039
89MP0001666_abnormal_nutrient_absorption0.39583699
90MP0003699_abnormal_female_reproductive0.36859727
91MP0000230_abnormal_systemic_arterial0.36770201
92MP0003119_abnormal_digestive_system0.35639572
93MP0000566_synostosis0.34822845
94MP0003631_nervous_system_phenotype0.34696457
95MP0004270_analgesia0.33649052
96MP0002882_abnormal_neuron_morphology0.33639467
97MP0010329_abnormal_lipoprotein_level0.33317394
98MP0000249_abnormal_blood_vessel0.33266964
99MP0003172_abnormal_lysosome_physiology0.32775695
100MP0005391_vision/eye_phenotype0.32488015

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.45333319
2Absent/shortened dynein arms (HP:0200106)6.01509369
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.01509369
4Attenuation of retinal blood vessels (HP:0007843)5.59696728
5Asymmetric septal hypertrophy (HP:0001670)5.49170806
6Bony spicule pigmentary retinopathy (HP:0007737)5.42534082
7Tubulointerstitial nephritis (HP:0001970)4.68320045
8Abnormal ciliary motility (HP:0012262)4.55639706
9Chronic hepatic failure (HP:0100626)4.55107241
10Abnormal respiratory motile cilium physiology (HP:0012261)4.45583115
11Resting tremor (HP:0002322)4.37952214
12Abnormal respiratory epithelium morphology (HP:0012253)4.32330066
13Abnormal respiratory motile cilium morphology (HP:0005938)4.32330066
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.25930822
15Hyperkalemia (HP:0002153)4.25124172
16Infertility (HP:0000789)4.23880225
17Nasal polyposis (HP:0100582)4.23633087
18Male infertility (HP:0003251)4.20033710
19Bell-shaped thorax (HP:0001591)4.07845122
20Abnormal rod and cone electroretinograms (HP:0008323)4.00175456
21Abnormality of macular pigmentation (HP:0008002)3.94161431
22Potter facies (HP:0002009)3.82402267
23Facial shape deformation (HP:0011334)3.82402267
24Cone-rod dystrophy (HP:0000548)3.78771168
25Hypoplastic ischia (HP:0003175)3.78623312
26Enlarged epiphyses (HP:0010580)3.78154321
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.77498055
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.50641011
29Abnormality of the nasal mucosa (HP:0000433)3.44627443
30Abnormal spermatogenesis (HP:0008669)3.38699677
31Abnormality of the ischium (HP:0003174)3.35269788
32Azoospermia (HP:0000027)3.33802090
33Progressive cerebellar ataxia (HP:0002073)3.26241040
34Impulsivity (HP:0100710)3.21145027
35Hypoplasia of the thymus (HP:0000778)3.05873205
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.01237347
37Postural instability (HP:0002172)3.00113340
38Hypoalphalipoproteinemia (HP:0003233)2.89517095
39Progressive sensorineural hearing impairment (HP:0000408)2.87438602
40Abnormal urine output (HP:0012590)2.84669343
41Unilateral renal agenesis (HP:0000122)2.78844512
42Nephronophthisis (HP:0000090)2.66149151
43Stage 5 chronic kidney disease (HP:0003774)2.65815431
44Abnormality of dental color (HP:0011073)2.64603419
45Amelogenesis imperfecta (HP:0000705)2.63277195
46Congenital malformation of the right heart (HP:0011723)2.61879816
47Double outlet right ventricle (HP:0001719)2.61879816
48Abnormality of the costochondral junction (HP:0000919)2.59527916
49Rhinitis (HP:0012384)2.57344824
50Truncal obesity (HP:0001956)2.56062195
51Generalized aminoaciduria (HP:0002909)2.53738113
52Abnormality of the aortic arch (HP:0012303)2.53312661
53Abnormality of potassium homeostasis (HP:0011042)2.48640958
54Abnormal drinking behavior (HP:0030082)2.47631292
55Polydipsia (HP:0001959)2.47631292
56Abnormality of renal excretion (HP:0011036)2.42937535
57Myokymia (HP:0002411)2.41638962
58Renal dysplasia (HP:0000110)2.40230985
59Portal hypertension (HP:0001409)2.38963104
60Menstrual irregularities (HP:0000858)2.37465716
61Insulin-resistant diabetes mellitus (HP:0000831)2.35531766
62Abnormality of the hepatic vasculature (HP:0006707)2.32426032
63Polyuria (HP:0000103)2.29745244
64Abnormality of the renal medulla (HP:0100957)2.24309463
65Horizontal nystagmus (HP:0000666)2.24058499
66Widely patent fontanelles and sutures (HP:0004492)2.22630255
67Renovascular hypertension (HP:0100817)2.22196860
68Tubulointerstitial abnormality (HP:0001969)2.21074983
69Atonic seizures (HP:0010819)2.20901250
70Decreased central vision (HP:0007663)2.18901054
71Renal Fanconi syndrome (HP:0001994)2.12431194
72Ventricular tachycardia (HP:0004756)2.12272456
73Epiphyseal dysplasia (HP:0002656)2.07174642
74Flattened epiphyses (HP:0003071)2.05519990
75Hyponatremia (HP:0002902)2.05198183
76Hypophosphatemic rickets (HP:0004912)2.02193747
77Abnormality of the parathyroid morphology (HP:0011766)2.01674750
78Bronchiectasis (HP:0002110)1.98635659
79Abnormality of the epiphysis of the femoral head (HP:0010574)1.95847382
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93423375
81Absent epiphyses (HP:0010577)1.93423375
82Osteomalacia (HP:0002749)1.92327399
83Abnormality of the pubic bones (HP:0003172)1.90220971
84Chronic bronchitis (HP:0004469)1.87724380
85Focal segmental glomerulosclerosis (HP:0000097)1.87487473
86Intellectual disability, moderate (HP:0002342)1.84196624
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84052794
88Tetany (HP:0001281)1.83396152
89Abnormality of femoral epiphyses (HP:0006499)1.81553724
90Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.81553724
91Bradycardia (HP:0001662)1.81295829
92Spastic paraparesis (HP:0002313)1.80277787
93Sensory axonal neuropathy (HP:0003390)1.79593527
94Photophobia (HP:0000613)1.79368196
95Optic nerve hypoplasia (HP:0000609)1.77979227
96Abnormal albumin level (HP:0012116)1.77157198
97Hypoalbuminemia (HP:0003073)1.77157198
98Progressive hearing impairment (HP:0001730)1.77153252
99Amblyopia (HP:0000646)1.77115683
100Flat capital femoral epiphysis (HP:0003370)1.76961396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.59364897
2TESK15.83634265
3DDR24.70580062
4INSRR3.92973465
5MAP4K23.58728964
6BRD43.24178566
7PLK23.20402699
8STK383.14961036
9PNCK2.80690096
10MAPK152.78043085
11CAMK1G2.24004479
12PRKD32.19549937
13STK38L2.14183033
14WNK11.91180327
15PIK3CG1.81832262
16MST1R1.66455148
17PDPK11.66035468
18PDK11.61249658
19DYRK1B1.40797115
20MAP3K91.39385856
21CDK121.38226715
22NEK61.24703384
23CDK71.20715317
24PTK2B1.16420084
25KSR21.03681581
26LATS20.94179537
27PRKG20.89634041
28SIK20.85116160
29AKT30.84751522
30CAMK1D0.83605014
31TYRO30.79748059
32MAP3K110.79085823
33BRAF0.76950200
34UHMK10.75364330
35PRKG10.74990721
36RPS6KA20.67515003
37MUSK0.67284167
38WNK40.66943719
39PRKAA20.65068819
40RPS6KA10.55991452
41MAP2K20.54859466
42CDK30.54827682
43ARAF0.54514986
44CAMK10.53290478
45ROCK10.49128687
46MAP3K80.47863579
47MAP3K20.47829597
48STK390.45881184
49NTRK30.44622079
50GSK3B0.44530223
51CDK20.41387950
52MAPK10.40737114
53PRKCG0.39938795
54CDK10.39657504
55LATS10.39639359
56SGK4940.39586694
57SGK2230.39586694
58MARK10.39133363
59MAP3K10.37779393
60MTOR0.37240620
61CDK40.36487357
62MAPK80.35783916
63TNIK0.35360273
64CAMK40.35342332
65RPS6KL10.35191047
66RPS6KC10.35191047
67TIE10.34302189
68RPS6KA60.33618212
69TESK20.32936064
70BMPR1B0.32262773
71MAP3K40.30625238
72BLK0.30187568
73PRKCZ0.28814297
74MARK20.28669055
75SGK10.28273036
76CHEK10.25936049
77FRK0.23995542
78PRKCB0.23698469
79MAPK140.23315737
80MAPK100.22542486
81MAPK110.20389213
82RIPK40.17519754
83BRSK10.16779284
84MET0.15735740
85PKN10.15188937
86OXSR10.14887417
87AKT10.14237221
88ADRBK20.13955462
89PRKACA0.12709691
90MAP3K130.12148796
91IKBKB0.10711749
92FER0.10388987
93PRKAA10.10351230
94CAMK2A0.10300532
95PRKACB0.10225743
96PRKCE0.09694333
97DYRK30.08877650
98JAK30.08627370
99SGK20.08101480
100PRKCA0.07122293

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.68182400
2Fatty acid biosynthesis_Homo sapiens_hsa000615.55810217
3Olfactory transduction_Homo sapiens_hsa047403.78981236
4Butanoate metabolism_Homo sapiens_hsa006502.53406309
5Taste transduction_Homo sapiens_hsa047422.09334909
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.09118315
7Type I diabetes mellitus_Homo sapiens_hsa049401.90095848
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89949369
9Allograft rejection_Homo sapiens_hsa053301.80074530
10Dorso-ventral axis formation_Homo sapiens_hsa043201.76945562
11Autoimmune thyroid disease_Homo sapiens_hsa053201.75353058
12Graft-versus-host disease_Homo sapiens_hsa053321.66876911
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58350479
14Antigen processing and presentation_Homo sapiens_hsa046121.57177081
15Type II diabetes mellitus_Homo sapiens_hsa049301.56504583
16Phenylalanine metabolism_Homo sapiens_hsa003601.43969817
17Fatty acid degradation_Homo sapiens_hsa000711.38714790
18RNA transport_Homo sapiens_hsa030131.30542018
19Phototransduction_Homo sapiens_hsa047441.27915981
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27620752
21Viral myocarditis_Homo sapiens_hsa054161.27302178
22Fatty acid metabolism_Homo sapiens_hsa012121.21768687
23Morphine addiction_Homo sapiens_hsa050321.21599095
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21135723
25Salivary secretion_Homo sapiens_hsa049701.19875628
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16239046
27Endocytosis_Homo sapiens_hsa041441.12267421
28Nicotine addiction_Homo sapiens_hsa050331.12258697
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08902034
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07276523
31Circadian entrainment_Homo sapiens_hsa047131.06127167
32Arginine and proline metabolism_Homo sapiens_hsa003301.05785989
33Calcium signaling pathway_Homo sapiens_hsa040201.05705418
34Inositol phosphate metabolism_Homo sapiens_hsa005621.05658545
35Cardiac muscle contraction_Homo sapiens_hsa042601.02869130
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.00468676
37Nitrogen metabolism_Homo sapiens_hsa009101.00409982
38Arginine biosynthesis_Homo sapiens_hsa002200.97139457
39Protein digestion and absorption_Homo sapiens_hsa049740.96807524
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93890088
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92823884
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92651811
43Glutamatergic synapse_Homo sapiens_hsa047240.91345315
44cAMP signaling pathway_Homo sapiens_hsa040240.85080937
45Synaptic vesicle cycle_Homo sapiens_hsa047210.84945752
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84197116
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82872060
48Estrogen signaling pathway_Homo sapiens_hsa049150.81544641
49Oocyte meiosis_Homo sapiens_hsa041140.78544827
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77434631
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76819297
52PPAR signaling pathway_Homo sapiens_hsa033200.75781048
53ABC transporters_Homo sapiens_hsa020100.75353542
54Influenza A_Homo sapiens_hsa051640.74626104
55Fat digestion and absorption_Homo sapiens_hsa049750.74386575
56GABAergic synapse_Homo sapiens_hsa047270.69938249
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.69285267
58Glycerolipid metabolism_Homo sapiens_hsa005610.68962480
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68687710
60Renin-angiotensin system_Homo sapiens_hsa046140.68591594
61Renin secretion_Homo sapiens_hsa049240.67321371
62Hedgehog signaling pathway_Homo sapiens_hsa043400.66827143
63Insulin secretion_Homo sapiens_hsa049110.66239621
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64539218
65Gastric acid secretion_Homo sapiens_hsa049710.64088166
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.62048160
67Serotonergic synapse_Homo sapiens_hsa047260.56882480
68Retinol metabolism_Homo sapiens_hsa008300.56304196
69Cholinergic synapse_Homo sapiens_hsa047250.56079543
70Long-term potentiation_Homo sapiens_hsa047200.55686555
71Tyrosine metabolism_Homo sapiens_hsa003500.55137809
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54555796
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.53969459
74VEGF signaling pathway_Homo sapiens_hsa043700.53480318
75Pancreatic secretion_Homo sapiens_hsa049720.52956437
76MAPK signaling pathway_Homo sapiens_hsa040100.47178899
77Bile secretion_Homo sapiens_hsa049760.45266719
78Long-term depression_Homo sapiens_hsa047300.41683701
79Basal transcription factors_Homo sapiens_hsa030220.40659051
80Purine metabolism_Homo sapiens_hsa002300.37766034
81Selenocompound metabolism_Homo sapiens_hsa004500.37614262
82Tight junction_Homo sapiens_hsa045300.33757423
83Oxytocin signaling pathway_Homo sapiens_hsa049210.32863934
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32776321
85Circadian rhythm_Homo sapiens_hsa047100.30850764
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30787724
87Huntingtons disease_Homo sapiens_hsa050160.27372598
88Acute myeloid leukemia_Homo sapiens_hsa052210.27283260
89Amphetamine addiction_Homo sapiens_hsa050310.27148844
90mRNA surveillance pathway_Homo sapiens_hsa030150.26495520
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.24691918
92Thyroid hormone synthesis_Homo sapiens_hsa049180.22299021
93Vitamin B6 metabolism_Homo sapiens_hsa007500.14371626
94Herpes simplex infection_Homo sapiens_hsa051680.14054063
95Cocaine addiction_Homo sapiens_hsa050300.14043356
96Sulfur relay system_Homo sapiens_hsa041220.13921654
97Fanconi anemia pathway_Homo sapiens_hsa034600.13371451
98Linoleic acid metabolism_Homo sapiens_hsa005910.11991890
99Viral carcinogenesis_Homo sapiens_hsa052030.11068363
100Choline metabolism in cancer_Homo sapiens_hsa052310.10542464

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