ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.59313788
2	acrosome reaction (GO:0007340)	9.23990226
3	sperm capacitation (GO:0048240)	8.18519656
4	plasma membrane fusion (GO:0045026)	7.74193646
5	negative regulation of inclusion body assembly (GO:0090084)	6.89163254
6	spermatid development (GO:0007286)	6.34435497
7	spermatid nucleus differentiation (GO:0007289)	6.32460188
8	chromosome condensation (GO:0030261)	6.23454796
9	opioid receptor signaling pathway (GO:0038003)	6.09392697
10	response to pheromone (GO:0019236)	6.00220818
11	DNA packaging (GO:0006323)	5.94549023
12	microtubule depolymerization (GO:0007019)	5.91363171
13	centriole replication (GO:0007099)	5.83548730
14	regulation of inclusion body assembly (GO:0090083)	5.76406690
15	protein polyglutamylation (GO:0018095)	5.62063825
16	sexual reproduction (GO:0019953)	5.55587882
17	protein targeting to Golgi (GO:0000042)	5.48070331
18	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.44312121
19	calcium ion-dependent exocytosis (GO:0017156)	5.43374056
20	sperm-egg recognition (GO:0035036)	5.39511859
21	multicellular organism reproduction (GO:0032504)	5.36548302
22	reproduction (GO:0000003)	5.22024401
23	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.21194373
24	establishment of protein localization to Golgi (GO:0072600)	5.13472833
25	microtubule polymerization or depolymerization (GO:0031109)	5.10730305
26	multicellular organismal movement (GO:0050879)	5.04597563
27	musculoskeletal movement (GO:0050881)	5.04597563
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.03685623
29	regulation of transcription involved in cell fate commitment (GO:0060850)	4.99397858
30	spermatogenesis (GO:0007283)	4.85213311
31	centriole assembly (GO:0098534)	4.83758586
32	male gamete generation (GO:0048232)	4.83394444
33	axonemal dynein complex assembly (GO:0070286)	4.76649209
34	single strand break repair (GO:0000012)	4.70836068
35	binding of sperm to zona pellucida (GO:0007339)	4.70023573
36	regulation of cilium movement (GO:0003352)	4.65784930
37	regulation of centriole replication (GO:0046599)	4.58887032
38	rRNA methylation (GO:0031167)	4.56074903
39	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	4.48687769
40	cell-cell recognition (GO:0009988)	4.42030569
41	gamete generation (GO:0007276)	4.40443676
42	microtubule severing (GO:0051013)	4.35668411
43	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.30249061
44	positive regulation of Rab GTPase activity (GO:0032851)	4.17741018
45	regulation of Rab GTPase activity (GO:0032313)	4.17741018
46	cerebellar granule cell differentiation (GO:0021707)	3.90600260
47	cilium or flagellum-dependent cell motility (GO:0001539)	3.85794936
48	C4-dicarboxylate transport (GO:0015740)	3.82370813
49	protein localization to Golgi apparatus (GO:0034067)	3.79542202
50	cellular ketone body metabolic process (GO:0046950)	3.76468251
51	single fertilization (GO:0007338)	3.75929305
52	sodium ion export (GO:0071436)	3.72493043
53	motile cilium assembly (GO:0044458)	3.71142701
54	multicellular organismal reproductive process (GO:0048609)	3.54149651
55	seminiferous tubule development (GO:0072520)	3.50835367
56	epithelial cilium movement (GO:0003351)	3.47640311
57	peptidyl-threonine dephosphorylation (GO:0035970)	3.44789492
58	regulation of microtubule-based movement (GO:0060632)	3.42152641
59	chaperone-mediated protein complex assembly (GO:0051131)	3.34870310
60	rRNA modification (GO:0000154)	3.34280200
61	germ cell development (GO:0007281)	3.34074257
62	metanephric nephron tubule development (GO:0072234)	3.31444084
63	metanephric tubule development (GO:0072170)	3.31444084
64	glomerular visceral epithelial cell development (GO:0072015)	3.29873086
65	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.29623854
66	ketone body metabolic process (GO:1902224)	3.25105803
67	peptide catabolic process (GO:0043171)	3.17266532
68	RNA destabilization (GO:0050779)	3.10781938
69	glomerular epithelial cell development (GO:0072310)	3.09454569
70	fertilization (GO:0009566)	3.08271345
71	neurotransmitter catabolic process (GO:0042135)	3.08219110
72	organic cation transport (GO:0015695)	3.05842383
73	short-term memory (GO:0007614)	3.04179708
74	cilium movement (GO:0003341)	3.03446616
75	phosphatidylcholine biosynthetic process (GO:0006656)	3.02687753
76	metanephric nephron epithelium development (GO:0072243)	3.02500525
77	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.01837773
78	cell wall macromolecule metabolic process (GO:0044036)	2.96395585
79	coenzyme catabolic process (GO:0009109)	2.91989927
80	nucleus organization (GO:0006997)	2.91555090
81	cerebral cortex neuron differentiation (GO:0021895)	2.90863992
82	negative regulation of Rho protein signal transduction (GO:0035024)	2.90431491
83	cell wall macromolecule catabolic process (GO:0016998)	2.89307621
84	neurofilament cytoskeleton organization (GO:0060052)	2.87974547
85	Golgi to endosome transport (GO:0006895)	2.83393670
86	regulation of guanylate cyclase activity (GO:0031282)	2.83283355
87	regulation of cGMP biosynthetic process (GO:0030826)	2.78734940
88	myelin maintenance (GO:0043217)	2.78453066
89	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.76281396
90	cellular response to pH (GO:0071467)	2.75993579
91	positive regulation of guanylate cyclase activity (GO:0031284)	2.75411089
92	membrane protein intracellular domain proteolysis (GO:0031293)	2.74189482
93	positive regulation of cGMP biosynthetic process (GO:0030828)	2.73671422
94	metanephric epithelium development (GO:0072207)	2.73069595
95	regulation of interleukin-13 production (GO:0032656)	2.72974126
96	collecting duct development (GO:0072044)	2.71899765
97	positive regulation of endothelial cell differentiation (GO:0045603)	2.71413753
98	cellular sodium ion homeostasis (GO:0006883)	2.68634687
99	chromatin silencing (GO:0006342)	2.67585971
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.1893264

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.84456757
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.95979489
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.59479596
4	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.47985418
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29986901
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.07766827
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.03779640
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96296025
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94584916
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.94584916
11	AR_21572438_ChIP-Seq_LNCaP_Human	1.93334751
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92698437
13	FUS_26573619_Chip-Seq_HEK293_Human	1.92601320
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.85473388
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.69271560
16	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.66193402
17	CBP_20019798_ChIP-Seq_JUKART_Human	1.65022327
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65022327
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.58531541
20	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.57115833
21	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.57045396
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55597072
23	RAC3_21632823_ChIP-Seq_H3396_Human	1.54407665
24	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.49658102
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.49630620
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47504910
27	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47049700
28	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.42892120
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42871816
30	AR_25329375_ChIP-Seq_VCAP_Human	1.42273768
31	ERA_21632823_ChIP-Seq_H3396_Human	1.41130986
32	VDR_22108803_ChIP-Seq_LS180_Human	1.40221191
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39647000
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.39002986
35	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.38953078
36	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38610684
37	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.38427065
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.38182477
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.36561717
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.36547339
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32559148
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31538865
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30924557
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30553671
45	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.30181796
46	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.30103448
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.28127420
48	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.27658493
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26331416
50	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.25260221
51	TP53_18474530_ChIP-ChIP_U2OS_Human	1.23194768
52	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.23188657
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22934574
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.22539102
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21423146
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21085686
57	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.19961357
58	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19445605
59	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.19381549
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.18863880
61	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18204104
62	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.18072453
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17173913
64	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.16733334
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.15922818
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.15590306
67	SMC4_20622854_ChIP-Seq_HELA_Human	1.15145571
68	P300_19829295_ChIP-Seq_ESCs_Human	1.14601239
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.14387579
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.14338838
71	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13903474
72	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.13291523
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.13291523
74	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.12600921
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12134438
76	RUNX_20019798_ChIP-Seq_JUKART_Human	1.11424547
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.11351541
78	GATA1_19941826_ChIP-Seq_K562_Human	1.11149787
79	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.10843393
80	LXR_22292898_ChIP-Seq_THP-1_Human	1.10325917
81	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10010310
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09437093
83	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09233489
84	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.09033551
85	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.05345279
86	E2F1_20622854_ChIP-Seq_HELA_Human	1.04278626
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03937415
88	STAT3_23295773_ChIP-Seq_U87_Human	1.03541415
89	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.02392033
90	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02386014
91	TP63_22573176_ChIP-Seq_HFKS_Human	1.01855647
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01268756
93	RXR_22108803_ChIP-Seq_LS180_Human	0.97734613
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97659829
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97659829
96	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.97625228
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97407567
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97299202
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97000315
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96569705

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.97498171
2	MP0003878_abnormal_ear_physiology	4.50229075
3	MP0005377_hearing/vestibular/ear_phenot	4.50229075
4	MP0005670_abnormal_white_adipose	3.55687563
5	MP0004742_abnormal_vestibular_system	3.30096772
6	MP0003698_abnormal_male_reproductive	3.26675020
7	MP0003011_delayed_dark_adaptation	3.06789558
8	MP0001929_abnormal_gametogenesis	2.77627763
9	MP0001485_abnormal_pinna_reflex	2.60557895
10	MP0003879_abnormal_hair_cell	2.30687577
11	MP0008569_lethality_at_weaning	2.22030985
12	MP0001486_abnormal_startle_reflex	2.10464359
13	MP0005423_abnormal_somatic_nervous	1.96629327
14	MP0002272_abnormal_nervous_system	1.92368406
15	MP0004270_analgesia	1.91376136
16	MP0002822_catalepsy	1.87222839
17	MP0002161_abnormal_fertility/fecundity	1.84492241
18	MP0000566_synostosis	1.83107300
19	MP0009046_muscle_twitch	1.82454233
20	MP0001440_abnormal_grooming_behavior	1.77700605
21	MP0000534_abnormal_ureter_morphology	1.75811812
22	MP0003646_muscle_fatigue	1.68098778
23	MP0004859_abnormal_synaptic_plasticity	1.62785759
24	MP0002067_abnormal_sensory_capabilities	1.58212167
25	MP0001984_abnormal_olfaction	1.48602432
26	MP0001348_abnormal_lacrimal_gland	1.45955938
27	MP0001968_abnormal_touch/_nociception	1.45011875
28	MP0003635_abnormal_synaptic_transmissio	1.42663888
29	MP0009745_abnormal_behavioral_response	1.35299206
30	MP0002064_seizures	1.35190278
31	MP0010329_abnormal_lipoprotein_level	1.35154470
32	MP0004484_altered_response_of	1.31649392
33	MP0001963_abnormal_hearing_physiology	1.31260608
34	MP0000678_abnormal_parathyroid_gland	1.31079008
35	MP0009115_abnormal_fat_cell	1.28652917
36	MP0005666_abnormal_adipose_tissue	1.26654071
37	MP0002735_abnormal_chemical_nociception	1.24597960
38	MP0005551_abnormal_eye_electrophysiolog	1.21620534
39	MP0001765_abnormal_ion_homeostasis	1.20746119
40	MP0002210_abnormal_sex_determination	1.17754603
41	MP0003880_abnormal_central_pattern	1.17627708
42	MP0002127_abnormal_cardiovascular_syste	1.16884273
43	MP0005365_abnormal_bile_salt	1.16463880
44	MP0000026_abnormal_inner_ear	1.14721499
45	MP0005448_abnormal_energy_balance	1.10824536
46	MP0005451_abnormal_body_composition	1.09036734
47	MP0002572_abnormal_emotion/affect_behav	1.06751194
48	MP0002734_abnormal_mechanical_nocicepti	1.06730838
49	MP0001529_abnormal_vocalization	1.05961966
50	MP0005253_abnormal_eye_physiology	1.05351079
51	MP0002132_abnormal_respiratory_system	1.04124803
52	MP0002229_neurodegeneration	1.03079862
53	MP0000955_abnormal_spinal_cord	1.02276418
54	MP0004085_abnormal_heartbeat	0.99961498
55	MP0003718_maternal_effect	0.99744310
56	MP0010386_abnormal_urinary_bladder	0.99703916
57	MP0001501_abnormal_sleep_pattern	0.97421452
58	MP0009697_abnormal_copulation	0.96752402
59	MP0008874_decreased_physiological_sensi	0.93658073
60	MP0005409_darkened_coat_color	0.93412401
61	MP0005085_abnormal_gallbladder_physiolo	0.93119306
62	MP0003122_maternal_imprinting	0.91149201
63	MP0001666_abnormal_nutrient_absorption	0.91119805
64	MP0002557_abnormal_social/conspecific_i	0.90537322
65	MP0000653_abnormal_sex_gland	0.89584253
66	MP0005332_abnormal_amino_acid	0.89543675
67	MP0003137_abnormal_impulse_conducting	0.88942925
68	MP0005379_endocrine/exocrine_gland_phen	0.88608354
69	MP0002249_abnormal_larynx_morphology	0.88514421
70	MP0008875_abnormal_xenobiotic_pharmacok	0.87680719
71	MP0005375_adipose_tissue_phenotype	0.87001254
72	MP0005636_abnormal_mineral_homeostasis	0.86654551
73	MP0001145_abnormal_male_reproductive	0.86583144
74	MP0002063_abnormal_learning/memory/cond	0.86155393
75	MP0004019_abnormal_vitamin_homeostasis	0.84750047
76	MP0000003_abnormal_adipose_tissue	0.84088331
77	MP0003633_abnormal_nervous_system	0.80975966
78	MP0003631_nervous_system_phenotype	0.79663763
79	MP0003329_amyloid_beta_deposits	0.79225184
80	MP0004036_abnormal_muscle_relaxation	0.78884801
81	MP0003632_abnormal_nervous_system	0.76937098
82	MP0002971_abnormal_brown_adipose	0.71988005
83	MP0001270_distended_abdomen	0.70574950
84	MP0008995_early_reproductive_senescence	0.69157813
85	MP0005167_abnormal_blood-brain_barrier	0.68611141
86	MP0002118_abnormal_lipid_homeostasis	0.65686247
87	MP0002736_abnormal_nociception_after	0.64538750
88	MP0005620_abnormal_muscle_contractility	0.63942810
89	MP0002882_abnormal_neuron_morphology	0.63758016
90	MP0002184_abnormal_innervation	0.63715506
91	MP0005535_abnormal_body_temperature	0.62372126
92	MP0002282_abnormal_trachea_morphology	0.61319111
93	MP0002638_abnormal_pupillary_reflex	0.60602028
94	MP0004510_myositis	0.59896363
95	MP0002139_abnormal_hepatobiliary_system	0.59456057
96	MP0002733_abnormal_thermal_nociception	0.58228630
97	MP0009379_abnormal_foot_pigmentation	0.57902016
98	MP0001970_abnormal_pain_threshold	0.57030483
99	MP0005310_abnormal_salivary_gland	0.56270655
100	MP0003959_abnormal_lean_body	0.55689903

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	5.44409517
2	Tubulointerstitial nephritis (HP:0001970)	5.11058511
3	Asymmetric septal hypertrophy (HP:0001670)	4.79475538
4	Bell-shaped thorax (HP:0001591)	4.33541098
5	Atonic seizures (HP:0010819)	4.22594025
6	Progressive cerebellar ataxia (HP:0002073)	4.04625839
7	Impulsivity (HP:0100710)	3.80425352
8	Congenital malformation of the right heart (HP:0011723)	3.70348296
9	Double outlet right ventricle (HP:0001719)	3.70348296
10	Horizontal nystagmus (HP:0000666)	3.67379152
11	Hyperkalemia (HP:0002153)	3.65099534
12	Action tremor (HP:0002345)	3.61073521
13	Facial shape deformation (HP:0011334)	3.55542032
14	Potter facies (HP:0002009)	3.55542032
15	Absent/shortened dynein arms (HP:0200106)	3.50377046
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.50377046
17	Attenuation of retinal blood vessels (HP:0007843)	3.45462208
18	Myokymia (HP:0002411)	3.44216015
19	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.37637098
20	Resting tremor (HP:0002322)	3.30634629
21	Infertility (HP:0000789)	3.28010429
22	Abnormal respiratory motile cilium physiology (HP:0012261)	3.23848363
23	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.23799765
24	Bony spicule pigmentary retinopathy (HP:0007737)	3.20731467
25	Postural instability (HP:0002172)	3.14785984
26	Hypoplasia of the thymus (HP:0000778)	3.09380153
27	Renal Fanconi syndrome (HP:0001994)	3.08948209
28	Scanning speech (HP:0002168)	3.08717150
29	Dysdiadochokinesis (HP:0002075)	3.07899439
30	Enlarged epiphyses (HP:0010580)	3.07803409
31	Febrile seizures (HP:0002373)	3.07421631
32	Abnormal ciliary motility (HP:0012262)	3.02710899
33	Male infertility (HP:0003251)	3.00971003
34	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.91914899
35	Hypoalphalipoproteinemia (HP:0003233)	2.88735367
36	Nasal polyposis (HP:0100582)	2.86189195
37	Epiphyseal dysplasia (HP:0002656)	2.83480167
38	Chronic hepatic failure (HP:0100626)	2.79147658
39	Cone-rod dystrophy (HP:0000548)	2.73594220
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.73549558
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.73549558
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.70146948
43	Generalized aminoaciduria (HP:0002909)	2.69121395
44	Exertional dyspnea (HP:0002875)	2.67672302
45	Spastic paraparesis (HP:0002313)	2.66064678
46	Abnormality of macular pigmentation (HP:0008002)	2.64847774
47	Dysmetric saccades (HP:0000641)	2.59394808
48	Absence seizures (HP:0002121)	2.54570680
49	Abnormality of the costochondral junction (HP:0000919)	2.50557801
50	Hypoplastic ischia (HP:0003175)	2.46259732
51	Abnormal urine output (HP:0012590)	2.45461518
52	Tubulointerstitial abnormality (HP:0001969)	2.42806059
53	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.40951589
54	Abnormality of urine glucose concentration (HP:0011016)	2.37667814
55	Glycosuria (HP:0003076)	2.37667814
56	Abnormality of the ischium (HP:0003174)	2.37348134
57	Abnormality of potassium homeostasis (HP:0011042)	2.37076735
58	Subcapsular cataract (HP:0000523)	2.36771830
59	Abnormality of the nasal mucosa (HP:0000433)	2.33321832
60	Progressive sensorineural hearing impairment (HP:0000408)	2.32051463
61	Abnormality of renal resorption (HP:0011038)	2.30958983
62	Widely patent fontanelles and sutures (HP:0004492)	2.30435205
63	Peripheral hypomyelination (HP:0007182)	2.28609311
64	Neoplasm of the heart (HP:0100544)	2.22120376
65	Intention tremor (HP:0002080)	2.16294034
66	Abnormal ventriculo-arterial connection (HP:0011563)	2.15761361
67	Transposition of the great arteries (HP:0001669)	2.15761361
68	Abnormal connection of the cardiac segments (HP:0011545)	2.15761361
69	Abnormality of renal excretion (HP:0011036)	2.09299388
70	Stage 5 chronic kidney disease (HP:0003774)	2.07863855
71	Abnormal spermatogenesis (HP:0008669)	2.07486606
72	Abnormal drinking behavior (HP:0030082)	2.07471668
73	Polydipsia (HP:0001959)	2.07471668
74	Confusion (HP:0001289)	2.06965732
75	Portal hypertension (HP:0001409)	2.04063984
76	Focal motor seizures (HP:0011153)	2.04042456
77	Azoospermia (HP:0000027)	2.03646212
78	Retinal dysplasia (HP:0007973)	2.03538802
79	Osteomalacia (HP:0002749)	2.01893620
80	Polar cataract (HP:0010696)	2.01362590
81	Type 2 muscle fiber atrophy (HP:0003554)	2.00186169
82	Rhinitis (HP:0012384)	2.00167170
83	Hemiparesis (HP:0001269)	2.00056714
84	Hypophosphatemic rickets (HP:0004912)	1.96113303
85	Epileptic encephalopathy (HP:0200134)	1.94918416
86	Hypoglycemic seizures (HP:0002173)	1.94515970
87	Muscle fiber atrophy (HP:0100295)	1.94447302
88	Abnormality of the pubic bones (HP:0003172)	1.93836408
89	Hypolipoproteinemia (HP:0010981)	1.93426139
90	Menstrual irregularities (HP:0000858)	1.91639093
91	Dysmetria (HP:0001310)	1.88902177
92	Abnormality of the hepatic vasculature (HP:0006707)	1.87008826
93	Abnormality of saccadic eye movements (HP:0000570)	1.86553184
94	Nephronophthisis (HP:0000090)	1.86213137
95	Abnormality of the vitreous humor (HP:0004327)	1.86011568
96	Increased circulating renin level (HP:0000848)	1.84872397
97	Abnormality of the parathyroid morphology (HP:0011766)	1.84509718
98	Dialeptic seizures (HP:0011146)	1.83525326
99	Truncal obesity (HP:0001956)	1.82829369
100	Decreased central vision (HP:0007663)	1.80032065

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.10769634
2	DDR2	5.38824866
3	TESK1	3.97044239
4	MAPK15	3.68542737
5	INSRR	3.08344586
6	PNCK	3.02632132
7	BRD4	2.64929307
8	MAP4K2	2.37473325
9	STK38	2.18959707
10	PLK2	2.11654308
11	MAP3K11	1.92581953
12	MAP3K2	1.76805037
13	PRKD3	1.75177833
14	RIPK4	1.68514938
15	STK38L	1.60175946
16	PDK1	1.58382827
17	TYRO3	1.48973923
18	WNK1	1.48062643
19	PDPK1	1.44809418
20	CASK	1.43607696
21	DYRK1B	1.42022910
22	CAMK1G	1.37360627
23	MST1R	1.31550697
24	CDK3	1.31036336
25	PIK3CG	1.23530917
26	MAP3K10	1.21164873
27	FGFR4	1.19163609
28	MAP3K1	1.12360571
29	NME1	1.11722071
30	KSR2	1.01240247
31	MARK1	0.96502432
32	AKT3	0.94346764
33	FGFR3	0.92424542
34	EPHB1	0.88970986
35	PRKG1	0.88390442
36	MAP2K2	0.85996475
37	ERN1	0.84241012
38	GRK5	0.83494019
39	TAF1	0.82519304
40	NEK6	0.80548857
41	EPHA3	0.79447556
42	CDK12	0.73954922
43	NTRK3	0.73763929
44	ACVR1B	0.73338944
45	PRKG2	0.71579404
46	STK39	0.70014230
47	MAP3K9	0.68340302
48	BRAF	0.67539326
49	WNK4	0.62342303
50	SGK494	0.61934912
51	SGK223	0.61934912
52	MAP3K4	0.59998102
53	LATS2	0.59885008
54	SIK2	0.58460592
55	RPS6KA1	0.57386840
56	DYRK3	0.54346821
57	SGK1	0.53140411
58	PRKCG	0.51314947
59	PRKAA2	0.50770626
60	RET	0.50282749
61	CAMK4	0.47615386
62	IRAK1	0.47562736
63	CDK7	0.44737734
64	CAMK1D	0.40503253
65	RPS6KA2	0.39415796
66	MAP3K12	0.38873102
67	PRKCZ	0.38702303
68	SGK2	0.38585394
69	PASK	0.38362165
70	ROCK1	0.38171868
71	MAPK10	0.37410256
72	OBSCN	0.37255434
73	CAMK2A	0.35756646
74	MTOR	0.35538439
75	CAMK1	0.35293346
76	MAPK1	0.35028445
77	PHKG2	0.34067273
78	PHKG1	0.34067273
79	PRKCB	0.33593674
80	GSK3B	0.32985762
81	MAPK8	0.32946997
82	OXSR1	0.31436063
83	MAP2K7	0.31093010
84	TIE1	0.29802654
85	RPS6KA3	0.29528218
86	PRKCE	0.29211173
87	BMPR2	0.28950179
88	PKN1	0.28512569
89	PDGFRA	0.26940318
90	SGK3	0.24032419
91	JAK2	0.23948871
92	EPHB2	0.23705745
93	NTRK2	0.23585972
94	PKN2	0.23377103
95	PRKACA	0.23288721
96	FGFR1	0.22637215
97	PRKAA1	0.22377430
98	MAP3K8	0.21697499
99	MAP2K4	0.20842449
100	CDK5	0.20369504

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.75051912
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.68902204
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.29782623
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.60752052
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.53908133
6	Olfactory transduction_Homo sapiens_hsa04740	2.24169572
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.22550725
8	GABAergic synapse_Homo sapiens_hsa04727	2.04833589
9	Morphine addiction_Homo sapiens_hsa05032	2.03420191
10	Nicotine addiction_Homo sapiens_hsa05033	1.93948498
11	Circadian entrainment_Homo sapiens_hsa04713	1.88471212
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.88223602
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.84257101
14	PPAR signaling pathway_Homo sapiens_hsa03320	1.81862841
15	Fatty acid degradation_Homo sapiens_hsa00071	1.72747574
16	Long-term depression_Homo sapiens_hsa04730	1.67328315
17	Taste transduction_Homo sapiens_hsa04742	1.67093392
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.58767604
19	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.55898909
20	Renin-angiotensin system_Homo sapiens_hsa04614	1.54980448
21	Butanoate metabolism_Homo sapiens_hsa00650	1.53846018
22	ABC transporters_Homo sapiens_hsa02010	1.50606635
23	Renin secretion_Homo sapiens_hsa04924	1.45716044
24	Gastric acid secretion_Homo sapiens_hsa04971	1.44407814
25	Salivary secretion_Homo sapiens_hsa04970	1.39392563
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.34343520
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27078914
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.26903768
29	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.25347927
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25185695
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.24545784
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.22285478
33	Long-term potentiation_Homo sapiens_hsa04720	1.19012968
34	Cholinergic synapse_Homo sapiens_hsa04725	1.18261234
35	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.17749814
36	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.12376705
37	Amphetamine addiction_Homo sapiens_hsa05031	1.12053039
38	Serotonergic synapse_Homo sapiens_hsa04726	1.11436390
39	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.05044490
40	Type II diabetes mellitus_Homo sapiens_hsa04930	1.04789869
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.01759678
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.01547356
43	Pancreatic secretion_Homo sapiens_hsa04972	1.00030341
44	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.99347803
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.98989970
46	Bile secretion_Homo sapiens_hsa04976	0.97397356
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96262775
48	Histidine metabolism_Homo sapiens_hsa00340	0.96064643
49	Estrogen signaling pathway_Homo sapiens_hsa04915	0.94808345
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94448751
51	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.94273933
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93346529
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84935574
54	Cocaine addiction_Homo sapiens_hsa05030	0.82140350
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81172329
56	Insulin secretion_Homo sapiens_hsa04911	0.80698090
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78951997
58	Mineral absorption_Homo sapiens_hsa04978	0.76668287
59	cAMP signaling pathway_Homo sapiens_hsa04024	0.74034476
60	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.73637304
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.71849808
62	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69114134
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68416655
64	African trypanosomiasis_Homo sapiens_hsa05143	0.67056283
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65703462
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.64331992
67	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61636618
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58612464
69	Retinol metabolism_Homo sapiens_hsa00830	0.58467509
70	Carbon metabolism_Homo sapiens_hsa01200	0.58132768
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.57664135
72	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.57618269
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57107371
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.55435330
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55082550
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52336957
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52139945
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51669432
79	Gap junction_Homo sapiens_hsa04540	0.48905720
80	Huntingtons disease_Homo sapiens_hsa05016	0.48563193
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48131035
82	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.48110897
83	Circadian rhythm_Homo sapiens_hsa04710	0.46429258
84	Tight junction_Homo sapiens_hsa04530	0.45516194
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.39890506
86	Prion diseases_Homo sapiens_hsa05020	0.35743501
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.32345498
88	Endocytosis_Homo sapiens_hsa04144	0.32319831
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.31248148
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30586598
91	Alzheimers disease_Homo sapiens_hsa05010	0.30372054
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30146166
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29026949
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.28418641
95	Glucagon signaling pathway_Homo sapiens_hsa04922	0.26580832
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.26052590
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25152112
98	Choline metabolism in cancer_Homo sapiens_hsa05231	0.23145964
99	ECM-receptor interaction_Homo sapiens_hsa04512	0.22846336
100	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.21113490

C20ORF202

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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