ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	4.44913133
2	response to peptidoglycan (GO:0032494)	4.02260705
3	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.79234906
4	protein maturation by protein folding (GO:0022417)	3.77840142
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.72263457
6	neutrophil activation involved in immune response (GO:0002283)	3.65222898
7	nucleobase-containing small molecule interconversion (GO:0015949)	3.30266170
8	viral transcription (GO:0019083)	3.28877123
9	regulation of superoxide anion generation (GO:0032928)	3.17525168
10	pentose-phosphate shunt (GO:0006098)	3.10034735
11	pinocytosis (GO:0006907)	3.08910509
12	GDP-mannose metabolic process (GO:0019673)	3.01746613
13	negative regulation of interleukin-12 production (GO:0032695)	3.00865357
14	translational termination (GO:0006415)	3.00398645
15	pentose metabolic process (GO:0019321)	2.95642954
16	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.93998682
17	ribosomal large subunit biogenesis (GO:0042273)	2.90856321
18	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.87837269
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.87021232
20	protein targeting to ER (GO:0045047)	2.85197848
21	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.78454928
22	cotranslational protein targeting to membrane (GO:0006613)	2.78195955
23	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.77488887
24	deoxyribose phosphate biosynthetic process (GO:0046385)	2.76331578
25	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.76331578
26	positive regulation by symbiont of host defense response (GO:0052509)	2.76164873
27	modulation by symbiont of host defense response (GO:0052031)	2.76164873
28	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.76164873
29	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.76164873
30	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.76164873
31	modulation by symbiont of host immune response (GO:0052553)	2.76164873
32	maturation of SSU-rRNA (GO:0030490)	2.76109788
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.75730649
34	protein localization to endoplasmic reticulum (GO:0070972)	2.74351128
35	pyrimidine-containing compound salvage (GO:0008655)	2.74305508
36	pyrimidine nucleoside salvage (GO:0043097)	2.74305508
37	respiratory burst (GO:0045730)	2.72099079
38	translational elongation (GO:0006414)	2.72049278
39	immunoglobulin mediated immune response (GO:0016064)	2.72034884
40	Golgi transport vesicle coating (GO:0048200)	2.71972773
41	COPI coating of Golgi vesicle (GO:0048205)	2.71972773
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.71624683
43	glycosphingolipid catabolic process (GO:0046479)	2.71567249
44	NADPH regeneration (GO:0006740)	2.69669984
45	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.68620961
46	NIK/NF-kappaB signaling (GO:0038061)	2.68246831
47	viral life cycle (GO:0019058)	2.68150257
48	daunorubicin metabolic process (GO:0044597)	2.64252747
49	polyketide metabolic process (GO:0030638)	2.64252747
50	doxorubicin metabolic process (GO:0044598)	2.64252747
51	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.64018048
52	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.63179570
53	detection of other organism (GO:0098543)	2.57001683
54	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.55291865
55	ribosomal small subunit assembly (GO:0000028)	2.54742932
56	glycolipid catabolic process (GO:0019377)	2.50730883
57	protein localization to endosome (GO:0036010)	2.49928605
58	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.49650864
59	detection of bacterium (GO:0016045)	2.49518870
60	ribonucleoprotein complex biogenesis (GO:0022613)	2.49358769
61	regulation of mast cell degranulation (GO:0043304)	2.47932023
62	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.47281798
63	glucose catabolic process (GO:0006007)	2.46491899
64	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	2.43134552
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.43093773
66	regulation of necrotic cell death (GO:0010939)	2.33775797
67	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.32106128
68	deoxyribonucleotide biosynthetic process (GO:0009263)	2.31258403
69	cellular protein complex disassembly (GO:0043624)	2.31253560
70	regulation of leukocyte degranulation (GO:0043300)	2.30819391
71	translational initiation (GO:0006413)	2.29407410
72	deoxyribose phosphate catabolic process (GO:0046386)	2.29073966
73	cellular response to arsenic-containing substance (GO:0071243)	2.28414305
74	mitochondrial calcium ion transport (GO:0006851)	2.27705062
75	B cell mediated immunity (GO:0019724)	2.26229450
76	granulocyte activation (GO:0036230)	2.25754100
77	deoxyribonucleotide catabolic process (GO:0009264)	2.25657979
78	guanosine-containing compound biosynthetic process (GO:1901070)	2.24945889
79	aminoglycoside antibiotic metabolic process (GO:0030647)	2.24446385
80	regulation of early endosome to late endosome transport (GO:2000641)	2.24322475
81	nucleotide salvage (GO:0043173)	2.23523175
82	protein retention in ER lumen (GO:0006621)	2.21193893
83	glucose 6-phosphate metabolic process (GO:0051156)	2.20566382
84	regulation of myeloid leukocyte mediated immunity (GO:0002886)	2.19565091
85	proteasome assembly (GO:0043248)	2.19120026
86	oligosaccharide catabolic process (GO:0009313)	2.18792494
87	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.18600660
88	myeloid dendritic cell differentiation (GO:0043011)	2.17516032
89	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	2.16613507
90	formation of translation preinitiation complex (GO:0001731)	2.16345231
91	detection of external biotic stimulus (GO:0098581)	2.16278103
92	nucleoside salvage (GO:0043174)	2.16063524
93	positive regulation of leukocyte degranulation (GO:0043302)	2.15818916
94	amino sugar catabolic process (GO:0046348)	2.15700658
95	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.15172031
96	myeloid cell homeostasis (GO:0002262)	2.14866560
97	regulation of translational termination (GO:0006449)	2.12782233
98	translation (GO:0006412)	2.12625043
99	positive regulation of monocyte chemotaxis (GO:0090026)	2.12156692
100	macrophage activation involved in immune response (GO:0002281)	2.12132491

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.18221044
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.82200787
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.82144487
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.59008927
5	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.50927401
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.41347678
7	VDR_21846776_ChIP-Seq_THP-1_Human	2.39664012
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.36967141
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.20436331
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.15685210
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.03678971
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.03215677
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.02112658
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02072167
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.92823698
16	MYC_22102868_ChIP-Seq_BL_Human	1.78004348
17	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.75339617
18	LXR_22292898_ChIP-Seq_THP-1_Human	1.67960350
19	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.67620083
20	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.66768840
21	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66324423
22	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.65856045
23	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.65381516
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.63276469
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.59213480
26	XRN2_22483619_ChIP-Seq_HELA_Human	1.59091768
27	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.58349040
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.56327475
29	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54786799
30	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.53716652
31	SPI1_23547873_ChIP-Seq_NB4_Human	1.53555275
32	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.51326620
33	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50071222
34	VDR_24763502_ChIP-Seq_THP-1_Human	1.48130229
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.47154168
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46794143
37	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.46057920
38	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.44638754
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.44260094
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44218798
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.42415955
42	RACK7_27058665_Chip-Seq_MCF-7_Human	1.41689445
43	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.40937365
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.40827563
45	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.40057404
46	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.40035010
47	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39963763
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39046350
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.38989758
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38633713
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.38388392
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.38107181
53	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.37828243
54	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.35355230
55	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35102478
56	* GABP_19822575_ChIP-Seq_HepG2_Human	1.34884531
57	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.32490575
58	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.31752093
59	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.31053686
60	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.29366635
61	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.27739858
62	TFEB_21752829_ChIP-Seq_HELA_Human	1.25803003
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25100510
64	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.24272501
65	MAF_26560356_Chip-Seq_TH1_Human	1.24248698
66	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.24200647
67	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.23295883
68	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.22721941
69	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.21246531
70	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.20745936
71	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.19933531
72	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.19624045
73	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.19024205
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.18046569
75	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.14262459
76	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.13525855
77	ATF3_27146783_Chip-Seq_COLON_Human	1.13254120
78	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.13191153
79	UTX_26944678_Chip-Seq_JUKART_Human	1.12471658
80	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12027505
81	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11066939
82	MAF_26560356_Chip-Seq_TH2_Human	1.10827868
83	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.10557737
84	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.10465557
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.10253703
86	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.07442471
87	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.06714297
88	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.06374552
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05982484
90	BCL6_27268052_Chip-Seq_Bcells_Human	1.05352680
91	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.04725152
92	* P68_20966046_ChIP-Seq_HELA_Human	1.04584308
93	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.04314014
94	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03044289
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.02789043
96	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.02637205
97	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.01621921
98	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.01602383
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.00982850
100	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00470312

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	3.66799071
2	MP0003806_abnormal_nucleotide_metabolis	3.18965723
3	MP0005058_abnormal_lysosome_morphology	3.12992290
4	MP0003436_decreased_susceptibility_to	2.85501849
5	MP0003191_abnormal_cellular_cholesterol	2.80081405
6	MP0009840_abnormal_foam_cell	2.79964756
7	MP0002877_abnormal_melanocyte_morpholog	2.52746976
8	MP0008260_abnormal_autophagy	2.40255852
9	MP0001835_abnormal_antigen_presentation	2.30794028
10	MP0009333_abnormal_splenocyte_physiolog	2.25166675
11	MP0003303_peritoneal_inflammation	2.20125505
12	MP0009785_altered_susceptibility_to	2.17788922
13	MP0002148_abnormal_hypersensitivity_rea	2.15480576
14	MP0002419_abnormal_innate_immunity	2.11219652
15	MP0000858_altered_metastatic_potential	2.06994082
16	MP0005025_abnormal_response_to	2.00449089
17	MP0005464_abnormal_platelet_physiology	1.99616795
18	MP0006082_CNS_inflammation	1.96243647
19	MP0010234_abnormal_vibrissa_follicle	1.87032185
20	MP0004185_abnormal_adipocyte_glucose	1.77360390
21	MP0005000_abnormal_immune_tolerance	1.76517928
22	MP0000685_abnormal_immune_system	1.72444948
23	MP0002139_abnormal_hepatobiliary_system	1.71789929
24	MP0009379_abnormal_foot_pigmentation	1.69791682
25	MP0003724_increased_susceptibility_to	1.65371209
26	MP0000343_altered_response_to	1.64863456
27	MP0001853_heart_inflammation	1.63278012
28	MP0000490_abnormal_crypts_of	1.63193977
29	MP0003453_abnormal_keratinocyte_physiol	1.62895041
30	MP0002452_abnormal_antigen_presenting	1.62522989
31	MP0002723_abnormal_immune_serum	1.55142072
32	MP0003186_abnormal_redox_activity	1.54610109
33	MP0002796_impaired_skin_barrier	1.53609766
34	MP0001790_abnormal_immune_system	1.53285199
35	MP0005387_immune_system_phenotype	1.53285199
36	MP0001819_abnormal_immune_cell	1.53098763
37	MP0002420_abnormal_adaptive_immunity	1.53007912
38	MP0003172_abnormal_lysosome_physiology	1.52730419
39	MP0004947_skin_inflammation	1.51217152
40	MP0005671_abnormal_response_to	1.51089582
41	MP0003693_abnormal_embryo_hatching	1.45989420
42	MP0003075_altered_response_to	1.43889182
43	MP0008469_abnormal_protein_level	1.43269257
44	MP0009764_decreased_sensitivity_to	1.42144228
45	MP0001800_abnormal_humoral_immune	1.41848702
46	MP0001845_abnormal_inflammatory_respons	1.40073036
47	MP0010155_abnormal_intestine_physiology	1.35739525
48	MP0001533_abnormal_skeleton_physiology	1.34607568
49	MP0004957_abnormal_blastocyst_morpholog	1.32798290
50	MP0004233_abnormal_muscle_weight	1.31390539
51	MP0004858_abnormal_nervous_system	1.30840753
52	MP0003705_abnormal_hypodermis_morpholog	1.30816711
53	MP0005501_abnormal_skin_physiology	1.29788089
54	MP0006036_abnormal_mitochondrial_physio	1.23025272
55	MP0005319_abnormal_enzyme/_coenzyme	1.22495524
56	MP0002132_abnormal_respiratory_system	1.20002339
57	MP0003300_gastrointestinal_ulcer	1.19534546
58	MP0000716_abnormal_immune_system	1.17823522
59	MP0002398_abnormal_bone_marrow	1.16696652
60	MP0005360_urolithiasis	1.14531905
61	MP0002429_abnormal_blood_cell	1.13934281
62	MP0009278_abnormal_bone_marrow	1.10010050
63	MP0003566_abnormal_cell_adhesion	1.08813336
64	MP0000604_amyloidosis	1.08332838
65	MP0003123_paternal_imprinting	1.06070265
66	MP0004264_abnormal_extraembryonic_tissu	1.06036619
67	MP0003448_altered_tumor_morphology	1.05841682
68	MP0002405_respiratory_system_inflammati	1.05038270
69	MP0002998_abnormal_bone_remodeling	1.04549514
70	MP0001545_abnormal_hematopoietic_system	1.04297701
71	MP0005397_hematopoietic_system_phenotyp	1.04297701
72	MP0002722_abnormal_immune_system	1.03463697
73	MP0003828_pulmonary_edema	1.01027638
74	MP0003763_abnormal_thymus_physiology	1.00236851
75	MP0005166_decreased_susceptibility_to	0.97626892
76	MP0000609_abnormal_liver_physiology	0.96995847
77	MP0003111_abnormal_nucleus_morphology	0.95576429
78	MP0000689_abnormal_spleen_morphology	0.95530542
79	MP0000678_abnormal_parathyroid_gland	0.95500431
80	MP0004510_myositis	0.94427665
81	MP0001216_abnormal_epidermal_layer	0.92116148
82	MP0003656_abnormal_erythrocyte_physiolo	0.91928957
83	MP0003221_abnormal_cardiomyocyte_apopto	0.91706478
84	MP0008007_abnormal_cellular_replicative	0.90943949
85	MP0000465_gastrointestinal_hemorrhage	0.89809275
86	MP0005666_abnormal_adipose_tissue	0.88517725
87	MP0009763_increased_sensitivity_to	0.87882717
88	MP0005365_abnormal_bile_salt	0.87012882
89	MP0005023_abnormal_wound_healing	0.85656395
90	MP0005165_increased_susceptibility_to	0.85350544
91	MP0000750_abnormal_muscle_regeneration	0.85315953
92	MP0001873_stomach_inflammation	0.83565336
93	MP0000313_abnormal_cell_death	0.83493159
94	MP0001727_abnormal_embryo_implantation	0.82774913
95	MP0003077_abnormal_cell_cycle	0.82147397
96	MP0005584_abnormal_enzyme/coenzyme_acti	0.81498864
97	MP0008932_abnormal_embryonic_tissue	0.81441619
98	MP0001849_ear_inflammation	0.81278214
99	MP0003866_abnormal_defecation	0.80079762
100	MP0008875_abnormal_xenobiotic_pharmacok	0.79960744

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of liposaccharide metabolism (HP:0010968)	4.17863707
2	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.17863707
3	Abnormality of glycolipid metabolism (HP:0010969)	4.17863707
4	Abnormality of macrophages (HP:0004311)	3.98990223
5	Eczematoid dermatitis (HP:0000976)	3.41080475
6	Recurrent abscess formation (HP:0002722)	3.34011472
7	Recurrent bacterial skin infections (HP:0005406)	3.29639003
8	Chronic obstructive pulmonary disease (HP:0006510)	3.15210647
9	Obstructive lung disease (HP:0006536)	3.15210647
10	Increased serum ferritin (HP:0003281)	3.00037968
11	Vertebral compression fractures (HP:0002953)	2.91789935
12	Increased cerebral lipofuscin (HP:0011813)	2.84385055
13	Ragged-red muscle fibers (HP:0003200)	2.82672362
14	Recurrent gram-negative bacterial infections (HP:0005420)	2.80029546
15	Vacuolated lymphocytes (HP:0001922)	2.79534548
16	Petechiae (HP:0000967)	2.67512920
17	Hepatosplenomegaly (HP:0001433)	2.67072710
18	Purpura (HP:0000979)	2.52830717
19	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.50301340
20	Achilles tendon contracture (HP:0001771)	2.47619820
21	Progressive neurologic deterioration (HP:0002344)	2.47156581
22	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.46834135
23	Rough bone trabeculation (HP:0100670)	2.44917829
24	Increased muscle lipid content (HP:0009058)	2.44315515
25	Abnormality of the Achilles tendon (HP:0005109)	2.42221205
26	Systemic lupus erythematosus (HP:0002725)	2.41709295
27	Increased intramyocellular lipid droplets (HP:0012240)	2.36949076
28	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.36482345
29	Increased IgM level (HP:0003496)	2.34216577
30	Loss of speech (HP:0002371)	2.34048637
31	Urticaria (HP:0001025)	2.33156072
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31718854
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31718854
34	Mediastinal lymphadenopathy (HP:0100721)	2.29557876
35	Progressive muscle weakness (HP:0003323)	2.26880455
36	Microretrognathia (HP:0000308)	2.25674612
37	Axonal loss (HP:0003447)	2.25668614
38	Abnormality of iron homeostasis (HP:0011031)	2.25624555
39	Multiple enchondromatosis (HP:0005701)	2.24794753
40	Amyloidosis (HP:0011034)	2.22740957
41	Dysostosis multiplex (HP:0000943)	2.19593173
42	Hypertensive crisis (HP:0100735)	2.19506542
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.19357784
44	Upper motor neuron abnormality (HP:0002127)	2.18497010
45	Myositis (HP:0100614)	2.18222822
46	Renal Fanconi syndrome (HP:0001994)	2.16405127
47	Elevated erythrocyte sedimentation rate (HP:0003565)	2.15936575
48	Prolonged neonatal jaundice (HP:0006579)	2.14533562
49	Distal lower limb muscle weakness (HP:0009053)	2.13488907
50	Hypokinesia (HP:0002375)	2.11856608
51	Abnormal trabecular bone morphology (HP:0100671)	2.08151077
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07030719
53	Trismus (HP:0000211)	2.00158347
54	Deep venous thrombosis (HP:0002625)	1.98149525
55	Orchitis (HP:0100796)	1.97539702
56	Cellulitis (HP:0100658)	1.97236945
57	Recurrent skin infections (HP:0001581)	1.96328308
58	Thrombocytosis (HP:0001894)	1.94926633
59	Microvesicular hepatic steatosis (HP:0001414)	1.94889123
60	Bone pain (HP:0002653)	1.94020481
61	Pallor (HP:0000980)	1.93139562
62	Acute necrotizing encephalopathy (HP:0006965)	1.90917193
63	Rhabdomyolysis (HP:0003201)	1.88009630
64	Stomatitis (HP:0010280)	1.86875948
65	Myocardial infarction (HP:0001658)	1.85070992
66	Generalized aminoaciduria (HP:0002909)	1.84779187
67	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.84485204
68	Gingivitis (HP:0000230)	1.84193083
69	Abnormality of the distal phalanges of the toes (HP:0010182)	1.83154124
70	Distal lower limb amyotrophy (HP:0008944)	1.82898222
71	Meningitis (HP:0001287)	1.80808604
72	Personality changes (HP:0000751)	1.80345023
73	Macrocytic anemia (HP:0001972)	1.80145137
74	Hyperparathyroidism (HP:0000843)	1.79827305
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.79496694
76	Abnormality of cells of the erythroid lineage (HP:0012130)	1.77115064
77	Mitochondrial inheritance (HP:0001427)	1.76335321
78	Acute hepatic failure (HP:0006554)	1.76049402
79	Autoimmune thrombocytopenia (HP:0001973)	1.74726180
80	Pathologic fracture (HP:0002756)	1.73777001
81	Hypertriglyceridemia (HP:0002155)	1.73618848
82	Polygenic inheritance (HP:0010982)	1.73512980
83	Aplastic anemia (HP:0001915)	1.73063712
84	Nausea (HP:0002018)	1.71973218
85	Malnutrition (HP:0004395)	1.71587930
86	Neoplasm of head and neck (HP:0012288)	1.71433855
87	Esophageal neoplasm (HP:0100751)	1.71433855
88	Recurrent viral infections (HP:0004429)	1.69969715
89	Respiratory difficulties (HP:0002880)	1.68137847
90	Fasciculations (HP:0002380)	1.67510385
91	Abnormality of transition element cation homeostasis (HP:0011030)	1.67462246
92	Recurrent fungal infections (HP:0002841)	1.66865906
93	Lipid accumulation in hepatocytes (HP:0006561)	1.64976974
94	Nail dystrophy (HP:0008404)	1.64832452
95	Abnormality of polysaccharide metabolism (HP:0011012)	1.63235595
96	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.63235595
97	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.63235595
98	Hepatocellular necrosis (HP:0001404)	1.63090550
99	Episodic fever (HP:0001954)	1.62628719
100	Gastrointestinal infarctions (HP:0005244)	1.62553957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.87468564
2	IRAK3	3.96462329
3	TESK2	3.25456749
4	ERN1	3.02188994
5	SMG1	2.28503886
6	MAP2K3	2.15147393
7	SCYL2	2.08522655
8	MAP3K11	2.08298348
9	ARAF	2.08286603
10	TESK1	2.06378060
11	EPHA2	2.05275221
12	TRIB3	2.03050888
13	IRAK4	1.88070744
14	PRPF4B	1.84145772
15	TAOK2	1.80267906
16	MST1R	1.62184359
17	ABL2	1.59736209
18	TYK2	1.59352681
19	RIPK4	1.59229077
20	PAK4	1.58956052
21	TBK1	1.48667514
22	MAP3K3	1.45484549
23	PIM2	1.43923457
24	BUB1	1.42651206
25	SIK1	1.33399948
26	MAP3K12	1.32028563
27	MAP4K1	1.25586850
28	BCKDK	1.23960714
29	KDR	1.23951254
30	EIF2AK1	1.23279306
31	STK16	1.22122704
32	VRK2	1.18522610
33	TAOK1	1.16457685
34	ZAP70	1.15043189
35	BLK	1.14604998
36	LIMK1	1.11212983
37	LRRK2	1.09493646
38	PBK	1.08504080
39	MAP3K1	1.07986578
40	CSK	1.07022943
41	IRAK2	1.05150782
42	GRK6	1.04214025
43	MOS	0.99009898
44	ICK	0.97955790
45	MAP3K13	0.95034944
46	ILK	0.92851749
47	MAP3K14	0.92118444
48	MAP3K8	0.91164699
49	TTN	0.90152746
50	PDK2	0.88480288
51	BRAF	0.88346168
52	SIK3	0.85849686
53	KSR2	0.84911814
54	RPS6KA4	0.84881845
55	BMPR2	0.84781078
56	PTK6	0.78180850
57	PRKG2	0.77111741
58	MATK	0.74125525
59	IKBKB	0.72465226
60	PDPK1	0.71127947
61	CSF1R	0.69485915
62	RPS6KB2	0.67577234
63	JAK3	0.64740318
64	AURKA	0.64415794
65	CDK7	0.62314458
66	MAPK11	0.60510241
67	TGFBR2	0.59415935
68	MAP3K6	0.57743255
69	STK10	0.53481147
70	BTK	0.52727006
71	PTK2	0.51493162
72	PAK1	0.49973960
73	MARK3	0.49946666
74	SRPK1	0.49918979
75	CDK19	0.49347053
76	MAP3K9	0.49310932
77	BMX	0.45936268
78	IKBKE	0.44694369
79	NEK1	0.42815068
80	RAF1	0.42372930
81	ERBB4	0.41678930
82	CDK4	0.40270565
83	EPHB1	0.40119762
84	MAPKAPK2	0.39627816
85	CDC7	0.39385227
86	HCK	0.39293021
87	PRKCI	0.39002640
88	FGR	0.37829012
89	PDK1	0.37621981
90	PKN2	0.36856781
91	DAPK1	0.36655905
92	CDK8	0.35167697
93	LYN	0.33021833
94	LATS2	0.31717214
95	AURKB	0.30550324
96	PRKCD	0.30283970
97	LMTK2	0.29983338
98	IRAK1	0.29826128
99	CLK1	0.29366802
100	FES	0.28735142

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.12462747
2	Proteasome_Homo sapiens_hsa03050	2.66791259
3	Other glycan degradation_Homo sapiens_hsa00511	2.48216556
4	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.31633516
5	DNA replication_Homo sapiens_hsa03030	2.02028405
6	Pentose phosphate pathway_Homo sapiens_hsa00030	1.92621414
7	Sulfur relay system_Homo sapiens_hsa04122	1.91795065
8	Lysosome_Homo sapiens_hsa04142	1.83592071
9	Galactose metabolism_Homo sapiens_hsa00052	1.80801106
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68309278
11	Leishmaniasis_Homo sapiens_hsa05140	1.67391396
12	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.66951061
13	Sulfur metabolism_Homo sapiens_hsa00920	1.61261156
14	Folate biosynthesis_Homo sapiens_hsa00790	1.56623175
15	Shigellosis_Homo sapiens_hsa05131	1.54819121
16	Osteoclast differentiation_Homo sapiens_hsa04380	1.52526780
17	Salmonella infection_Homo sapiens_hsa05132	1.51826617
18	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.51599904
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.51060276
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49509570
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.46423378
22	Bladder cancer_Homo sapiens_hsa05219	1.41240903
23	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.41125885
24	Base excision repair_Homo sapiens_hsa03410	1.40562464
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.39452930
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38117679
27	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.37009987
28	Tuberculosis_Homo sapiens_hsa05152	1.31081557
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.29165071
30	Parkinsons disease_Homo sapiens_hsa05012	1.27926325
31	Vibrio cholerae infection_Homo sapiens_hsa05110	1.26068121
32	Legionellosis_Homo sapiens_hsa05134	1.23181435
33	Phagosome_Homo sapiens_hsa04145	1.23171648
34	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.15615060
35	Glutathione metabolism_Homo sapiens_hsa00480	1.13006050
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11467559
37	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.10505354
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.10295251
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.08539943
40	Carbon metabolism_Homo sapiens_hsa01200	1.07896030
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.04320150
42	Acute myeloid leukemia_Homo sapiens_hsa05221	1.04226268
43	Allograft rejection_Homo sapiens_hsa05330	1.03847600
44	Apoptosis_Homo sapiens_hsa04210	1.01523608
45	Herpes simplex infection_Homo sapiens_hsa05168	1.00377022
46	Pertussis_Homo sapiens_hsa05133	0.99457731
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.98607607
48	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.98366085
49	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.96868023
50	Influenza A_Homo sapiens_hsa05164	0.96089903
51	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.95623623
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93441391
53	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.93151035
54	Spliceosome_Homo sapiens_hsa03040	0.92910950
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.91600545
56	Viral myocarditis_Homo sapiens_hsa05416	0.91245791
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.91201675
58	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.90352729
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89314032
60	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.88476764
61	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.88176097
62	Malaria_Homo sapiens_hsa05144	0.86388398
63	Pancreatic cancer_Homo sapiens_hsa05212	0.85513006
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.85495425
65	Asthma_Homo sapiens_hsa05310	0.85172533
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.84474339
67	Alzheimers disease_Homo sapiens_hsa05010	0.83724448
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.83434379
69	Toxoplasmosis_Homo sapiens_hsa05145	0.83147317
70	Mismatch repair_Homo sapiens_hsa03430	0.82823537
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81442843
72	Huntingtons disease_Homo sapiens_hsa05016	0.77796397
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.77228017
74	Prion diseases_Homo sapiens_hsa05020	0.75337023
75	Measles_Homo sapiens_hsa05162	0.75238435
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74498627
77	TNF signaling pathway_Homo sapiens_hsa04668	0.74136849
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73009675
79	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.72535453
80	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.71329358
81	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.70210777
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69939733
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67572274
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67273226
85	Hepatitis B_Homo sapiens_hsa05161	0.67131161
86	Non-small cell lung cancer_Homo sapiens_hsa05223	0.64091844
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.63498339
88	VEGF signaling pathway_Homo sapiens_hsa04370	0.63437718
89	Hepatitis C_Homo sapiens_hsa05160	0.63409288
90	Viral carcinogenesis_Homo sapiens_hsa05203	0.61430135
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58440156
92	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.55670779
93	Thyroid cancer_Homo sapiens_hsa05216	0.55208359
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51810649
95	Endocytosis_Homo sapiens_hsa04144	0.50807274
96	RNA polymerase_Homo sapiens_hsa03020	0.49181694
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.47642029
98	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.47404860
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.45596241
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42955662

C20ORF24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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