ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	4.70211640
2	protein maturation by protein folding (GO:0022417)	4.67189065
3	DNA unwinding involved in DNA replication (GO:0006268)	4.56314545
4	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.48276310
5	formation of translation preinitiation complex (GO:0001731)	4.31375895
6	DNA strand elongation involved in DNA replication (GO:0006271)	4.17000123
7	DNA strand elongation (GO:0022616)	4.09023469
8	peptidyl-arginine omega-N-methylation (GO:0035247)	3.97674051
9	viral transcription (GO:0019083)	3.95615143
10	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.94990068
11	nucleobase-containing small molecule interconversion (GO:0015949)	3.92969798
12	proline biosynthetic process (GO:0006561)	3.92704443
13	establishment of integrated proviral latency (GO:0075713)	3.91255069
14	ribosomal small subunit assembly (GO:0000028)	3.85348540
15	telomere maintenance via semi-conservative replication (GO:0032201)	3.82306452
16	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.80077058
17	pentose-phosphate shunt (GO:0006098)	3.74736103
18	pentose metabolic process (GO:0019321)	3.71824579
19	translational termination (GO:0006415)	3.71194874
20	GDP-mannose metabolic process (GO:0019673)	3.71036151
21	guanosine-containing compound biosynthetic process (GO:1901070)	3.66995250
22	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.62634501
23	regulation of mitochondrial translation (GO:0070129)	3.59529319
24	histone arginine methylation (GO:0034969)	3.58456198
25	translational elongation (GO:0006414)	3.57885739
26	establishment of viral latency (GO:0019043)	3.54933960
27	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.49514241
28	ribonucleoprotein complex biogenesis (GO:0022613)	3.48205471
29	NADPH regeneration (GO:0006740)	3.42061334
30	maturation of SSU-rRNA (GO:0030490)	3.41231089
31	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.37685881
32	ribosomal large subunit biogenesis (GO:0042273)	3.36113608
33	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.33575474
34	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.33238858
35	DNA replication initiation (GO:0006270)	3.31512211
36	UTP biosynthetic process (GO:0006228)	3.31230367
37	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.27367355
38	glucose catabolic process (GO:0006007)	3.27070610
39	ribosome biogenesis (GO:0042254)	3.21352699
40	protein targeting to ER (GO:0045047)	3.18643701
41	cotranslational protein targeting to membrane (GO:0006613)	3.16657642
42	ncRNA 3-end processing (GO:0043628)	3.15864918
43	viral life cycle (GO:0019058)	3.15844929
44	viral mRNA export from host cell nucleus (GO:0046784)	3.15744952
45	peptidyl-arginine N-methylation (GO:0035246)	3.15565935
46	peptidyl-arginine methylation (GO:0018216)	3.15565935
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.15405157
48	rRNA transcription (GO:0009303)	3.12572972
49	translational initiation (GO:0006413)	3.12287895
50	CTP metabolic process (GO:0046036)	3.10362079
51	CTP biosynthetic process (GO:0006241)	3.10362079
52	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.10270823
53	protein retention in ER lumen (GO:0006621)	3.09156984
54	regulation of translational fidelity (GO:0006450)	3.08445942
55	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.07867831
56	nuclear envelope reassembly (GO:0031468)	3.07654317
57	mitotic nuclear envelope reassembly (GO:0007084)	3.07654317
58	regulation of translational termination (GO:0006449)	3.07011135
59	protein localization to endoplasmic reticulum (GO:0070972)	3.04927029
60	protein targeting to mitochondrion (GO:0006626)	3.04327941
61	heterochromatin organization (GO:0070828)	3.02507968
62	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.00654409
63	telomere maintenance via recombination (GO:0000722)	2.97953955
64	L-serine metabolic process (GO:0006563)	2.97883616
65	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97833982
66	mitotic chromosome condensation (GO:0007076)	2.93548840
67	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.92356804
68	cellular protein complex disassembly (GO:0043624)	2.92157300
69	GTP biosynthetic process (GO:0006183)	2.91983688
70	UTP metabolic process (GO:0046051)	2.91224122
71	pseudouridine synthesis (GO:0001522)	2.90116637
72	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.90017111
73	negative regulation of ligase activity (GO:0051352)	2.87684356
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.87684356
75	translation (GO:0006412)	2.87612047
76	protein complex localization (GO:0031503)	2.85945574
77	heme biosynthetic process (GO:0006783)	2.85259290
78	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.84840149
79	chaperone-mediated protein transport (GO:0072321)	2.84572692
80	deoxyribose phosphate biosynthetic process (GO:0046385)	2.80565317
81	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.80565317
82	protein complex disassembly (GO:0043241)	2.80162862
83	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.80157746
84	cellular component biogenesis (GO:0044085)	2.79069328
85	GMP metabolic process (GO:0046037)	2.78878322
86	establishment of protein localization to mitochondrion (GO:0072655)	2.78725445
87	folic acid metabolic process (GO:0046655)	2.78649527
88	proteasome assembly (GO:0043248)	2.78040466
89	Golgi transport vesicle coating (GO:0048200)	2.77888684
90	COPI coating of Golgi vesicle (GO:0048205)	2.77888684
91	spliceosomal snRNP assembly (GO:0000387)	2.77688522
92	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.74417668
93	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.74003380
94	mitotic recombination (GO:0006312)	2.73502363
95	negative regulation of RNA splicing (GO:0033119)	2.71021141
96	UV protection (GO:0009650)	2.70025248
97	purine nucleobase biosynthetic process (GO:0009113)	2.69866405
98	mitochondrial fusion (GO:0008053)	2.69717305
99	IMP biosynthetic process (GO:0006188)	2.68489516
100	negative regulation of mRNA processing (GO:0050686)	2.68314882

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.12699589
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.97260711
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.40654660
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.24984908
5	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.70354579
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.59133024
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.46459538
8	VDR_21846776_ChIP-Seq_THP-1_Human	2.36188472
9	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.27226003
10	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.26317407
11	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.23135280
12	XRN2_22483619_ChIP-Seq_HELA_Human	2.17709254
13	MYC_22102868_ChIP-Seq_BL_Human	2.13701578
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.07056132
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.04693973
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.01746643
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96768018
18	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.94877000
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.94074575
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.94044940
21	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.93566858
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.91715403
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91577517
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.90011305
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82568341
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80710053
27	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.79936710
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.79932697
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.75244081
30	LXR_22292898_ChIP-Seq_THP-1_Human	1.75039499
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.74848755
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.72902312
33	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.67388668
34	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.64383747
35	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.62988346
36	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.55084202
37	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.52909400
38	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.49862665
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49590079
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49449717
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.49248878
42	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.47286167
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.46558426
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46025932
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44662204
46	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.42345606
47	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.39941651
48	RACK7_27058665_Chip-Seq_MCF-7_Human	1.36838396
49	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.36794944
50	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.35503796
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.35367593
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34381336
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33945032
54	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.33558292
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.31007637
56	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.29470207
57	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.29375589
58	* P68_20966046_ChIP-Seq_HELA_Human	1.29177320
59	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.29135142
60	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.25631321
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25624542
62	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.23199704
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.23098539
64	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23073884
65	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.22918422
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.21124970
67	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20526875
68	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.19714634
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17961684
70	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.16972279
71	* ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16268058
72	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.14577806
73	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.13538533
74	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.13356419
75	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12811215
76	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10980656
77	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.10870189
78	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.10278340
79	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.09582271
80	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.09141779
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.08168173
82	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.07806391
83	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.06598183
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05905759
85	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.04757810
86	VDR_24763502_ChIP-Seq_THP-1_Human	1.03361513
87	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.02622545
88	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02566785
89	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.02477964
90	TFEB_21752829_ChIP-Seq_HELA_Human	1.02332559
91	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.01885854
92	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.01882108
93	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00427581
94	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99628375
95	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.99251368
96	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.99195471
97	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.97598524
98	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.97063594
99	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.96798968
100	* BCL6_27268052_Chip-Seq_Bcells_Human	0.96774455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003111_abnormal_nucleus_morphology	3.58711249
2	MP0003693_abnormal_embryo_hatching	3.57744667
3	MP0010094_abnormal_chromosome_stability	3.23823648
4	MP0004957_abnormal_blastocyst_morpholog	3.22249712
5	MP0003806_abnormal_nucleotide_metabolis	3.06919512
6	MP0005058_abnormal_lysosome_morphology	2.93640854
7	MP0008260_abnormal_autophagy	2.91675963
8	MP0004185_abnormal_adipocyte_glucose	2.83688410
9	MP0003077_abnormal_cell_cycle	2.79643552
10	MP0002877_abnormal_melanocyte_morpholog	2.69217436
11	MP0008932_abnormal_embryonic_tissue	2.65692252
12	MP0003705_abnormal_hypodermis_morpholog	2.35105008
13	MP0000490_abnormal_crypts_of	2.32708657
14	MP0003123_paternal_imprinting	2.29327057
15	MP0009278_abnormal_bone_marrow	2.27284154
16	MP0009379_abnormal_foot_pigmentation	2.17394660
17	MP0008058_abnormal_DNA_repair	2.16268227
18	MP0005451_abnormal_body_composition	2.15629548
19	MP0003186_abnormal_redox_activity	2.05002910
20	MP0001730_embryonic_growth_arrest	1.95681025
21	MP0005501_abnormal_skin_physiology	1.88872937
22	MP0000350_abnormal_cell_proliferation	1.82867969
23	MP0003315_abnormal_perineum_morphology	1.80045426
24	MP0000678_abnormal_parathyroid_gland	1.76747415
25	MP0008007_abnormal_cellular_replicative	1.75798271
26	MP0006036_abnormal_mitochondrial_physio	1.72194595
27	MP0009333_abnormal_splenocyte_physiolog	1.69912070
28	MP0004233_abnormal_muscle_weight	1.69034540
29	MP0000313_abnormal_cell_death	1.68071894
30	MP0006035_abnormal_mitochondrial_morpho	1.68024771
31	MP0003786_premature_aging	1.64032942
32	MP0005083_abnormal_biliary_tract	1.63760879
33	MP0001849_ear_inflammation	1.58871501
34	MP0002080_prenatal_lethality	1.56977450
35	MP0000358_abnormal_cell_content/	1.56063441
36	MP0004858_abnormal_nervous_system	1.51652272
37	MP0002396_abnormal_hematopoietic_system	1.50393598
38	MP0010030_abnormal_orbit_morphology	1.49940575
39	MP0000858_altered_metastatic_potential	1.43272736
40	MP0002796_impaired_skin_barrier	1.42317217
41	MP0005666_abnormal_adipose_tissue	1.41553951
42	MP0005076_abnormal_cell_differentiation	1.37131011
43	MP0005670_abnormal_white_adipose	1.32997696
44	MP0005464_abnormal_platelet_physiology	1.31215396
45	MP0009672_abnormal_birth_weight	1.26700958
46	MP0005380_embryogenesis_phenotype	1.23487329
47	MP0001672_abnormal_embryogenesis/_devel	1.23487329
48	MP0002019_abnormal_tumor_incidence	1.21468473
49	MP0001697_abnormal_embryo_size	1.19283796
50	MP0003191_abnormal_cellular_cholesterol	1.15136772
51	MP0000537_abnormal_urethra_morphology	1.13751612
52	MP0002089_abnormal_postnatal_growth/wei	1.10397979
53	MP0004808_abnormal_hematopoietic_stem	1.07565451
54	MP0002163_abnormal_gland_morphology	1.06635070
55	MP0003984_embryonic_growth_retardation	1.04514780
56	MP0002085_abnormal_embryonic_tissue	1.03912910
57	MP0003172_abnormal_lysosome_physiology	1.02775068
58	MP0001545_abnormal_hematopoietic_system	1.01766309
59	MP0005397_hematopoietic_system_phenotyp	1.01766309
60	MP0005384_cellular_phenotype	0.99086335
61	MP0002088_abnormal_embryonic_growth/wei	0.95019418
62	MP0009053_abnormal_anal_canal	0.94666579
63	MP0005621_abnormal_cell_physiology	0.91294897
64	MP0005375_adipose_tissue_phenotype	0.91190834
65	MP0002249_abnormal_larynx_morphology	0.91156416
66	MP0002132_abnormal_respiratory_system	0.89263247
67	MP0002722_abnormal_immune_system	0.87706235
68	MP0001853_heart_inflammation	0.87615090
69	MP0000703_abnormal_thymus_morphology	0.87419356
70	MP0001727_abnormal_embryo_implantation	0.86987847
71	MP0001661_extended_life_span	0.86205318
72	MP0003436_decreased_susceptibility_to	0.84995336
73	MP0000750_abnormal_muscle_regeneration	0.84879127
74	MP0003566_abnormal_cell_adhesion	0.84835352
75	MP0003718_maternal_effect	0.84081965
76	MP0001529_abnormal_vocalization	0.82562341
77	MP0000343_altered_response_to	0.80976597
78	MP0002429_abnormal_blood_cell	0.80594748
79	MP0005165_increased_susceptibility_to	0.79145050
80	MP0000003_abnormal_adipose_tissue	0.78104972
81	MP0000681_abnormal_thyroid_gland	0.78075650
82	MP0003453_abnormal_keratinocyte_physiol	0.78017508
83	MP0005330_cardiomyopathy	0.77254940
84	MP0010307_abnormal_tumor_latency	0.77141366
85	MP0002086_abnormal_extraembryonic_tissu	0.76294177
86	MP0000747_muscle_weakness	0.76235581
87	MP0005075_abnormal_melanosome_morpholog	0.75985336
88	MP0002398_abnormal_bone_marrow	0.75312427
89	MP0000462_abnormal_digestive_system	0.74894002
90	MP0000015_abnormal_ear_pigmentation	0.74073894
91	MP0002060_abnormal_skin_morphology	0.73252239
92	MP0009931_abnormal_skin_appearance	0.70938321
93	MP0003075_altered_response_to	0.70694370
94	MP0001881_abnormal_mammary_gland	0.69310469
95	MP0005257_abnormal_intraocular_pressure	0.66480348
96	MP0002970_abnormal_white_adipose	0.66234063
97	MP0000689_abnormal_spleen_morphology	0.64396021
98	MP0001186_pigmentation_phenotype	0.64214082
99	MP0005381_digestive/alimentary_phenotyp	0.60911575
100	MP0002075_abnormal_coat/hair_pigmentati	0.60406697

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.58588406
2	Ragged-red muscle fibers (HP:0003200)	3.52561088
3	Progressive muscle weakness (HP:0003323)	3.45009783
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.43190885
5	Microvesicular hepatic steatosis (HP:0001414)	3.38204371
6	Abnormal number of erythroid precursors (HP:0012131)	3.25689536
7	Cholecystitis (HP:0001082)	3.24307851
8	Abnormal gallbladder physiology (HP:0012438)	3.24307851
9	Reticulocytopenia (HP:0001896)	3.02781183
10	Broad distal phalanx of finger (HP:0009836)	3.00904333
11	Achilles tendon contracture (HP:0001771)	2.91829673
12	Multiple enchondromatosis (HP:0005701)	2.89752559
13	Rough bone trabeculation (HP:0100670)	2.84896391
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.83237715
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.83237715
16	Trismus (HP:0000211)	2.80715776
17	Abnormality of glycolysis (HP:0004366)	2.72109177
18	Vertebral compression fractures (HP:0002953)	2.71491575
19	Testicular atrophy (HP:0000029)	2.65830929
20	Hepatocellular necrosis (HP:0001404)	2.63595517
21	Hyperacusis (HP:0010780)	2.61294237
22	Increased intramyocellular lipid droplets (HP:0012240)	2.57211892
23	Microretrognathia (HP:0000308)	2.52311299
24	Increased muscle lipid content (HP:0009058)	2.49761103
25	Selective tooth agenesis (HP:0001592)	2.46935177
26	Hypertensive crisis (HP:0100735)	2.45567006
27	Abnormality of the Achilles tendon (HP:0005109)	2.44424411
28	Insomnia (HP:0100785)	2.43759105
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.43034578
30	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.43033407
31	Abnormality of the umbilical cord (HP:0010881)	2.42545332
32	Upper motor neuron abnormality (HP:0002127)	2.38355429
33	Increased cerebral lipofuscin (HP:0011813)	2.37744221
34	Pallor (HP:0000980)	2.29885827
35	Abnormality of reticulocytes (HP:0004312)	2.28830249
36	Hepatosplenomegaly (HP:0001433)	2.28775857
37	Increased serum pyruvate (HP:0003542)	2.27792978
38	Petechiae (HP:0000967)	2.25575832
39	Hepatic necrosis (HP:0002605)	2.22392973
40	Short nail (HP:0001799)	2.20687750
41	Thoracic kyphosis (HP:0002942)	2.17678333
42	Mitochondrial inheritance (HP:0001427)	2.17195551
43	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.15446671
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14927436
45	Abnormal trabecular bone morphology (HP:0100671)	2.13780344
46	Renal Fanconi syndrome (HP:0001994)	2.10441618
47	Type I transferrin isoform profile (HP:0003642)	2.09233079
48	Abnormality of the fetal cardiovascular system (HP:0010948)	2.07977269
49	Abnormal umbilical cord blood vessels (HP:0011403)	2.07977269
50	Single umbilical artery (HP:0001195)	2.07977269
51	Increased serum lactate (HP:0002151)	2.06841859
52	Increased CSF lactate (HP:0002490)	2.04385900
53	Long palpebral fissure (HP:0000637)	2.03567783
54	Distal lower limb muscle weakness (HP:0009053)	2.03517293
55	Acute necrotizing encephalopathy (HP:0006965)	2.02926532
56	Macrocytic anemia (HP:0001972)	2.02788264
57	Myopathic facies (HP:0002058)	2.02240900
58	Abnormality of the thoracic spine (HP:0100711)	2.01191021
59	Obstructive lung disease (HP:0006536)	1.99271882
60	Chronic obstructive pulmonary disease (HP:0006510)	1.99271882
61	Exercise intolerance (HP:0003546)	1.97556425
62	Acute encephalopathy (HP:0006846)	1.96709816
63	Hypokinesia (HP:0002375)	1.95124959
64	Diaphragmatic weakness (HP:0009113)	1.94496190
65	Lactic acidosis (HP:0003128)	1.94204162
66	Reticulocytosis (HP:0001923)	1.93800860
67	Thrombocytosis (HP:0001894)	1.92368686
68	Respiratory difficulties (HP:0002880)	1.91203505
69	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.90528013
70	Cholelithiasis (HP:0001081)	1.88278706
71	Breast hypoplasia (HP:0003187)	1.87772797
72	Redundant skin (HP:0001582)	1.86750432
73	Increased serum ferritin (HP:0003281)	1.86148946
74	Reduced antithrombin III activity (HP:0001976)	1.85672459
75	Fasciculations (HP:0002380)	1.85458281
76	Opisthotonus (HP:0002179)	1.84333796
77	Spastic diplegia (HP:0001264)	1.83602622
78	Prolonged neonatal jaundice (HP:0006579)	1.83434284
79	Hyperthyroidism (HP:0000836)	1.83309454
80	Generalized amyotrophy (HP:0003700)	1.81304997
81	Distal lower limb amyotrophy (HP:0008944)	1.80722703
82	Increased hepatocellular lipid droplets (HP:0006565)	1.78794364
83	Abnormality of the gallbladder (HP:0005264)	1.77750267
84	Death in infancy (HP:0001522)	1.75871766
85	Truncus arteriosus (HP:0001660)	1.74708157
86	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.74265819
87	Septate vagina (HP:0001153)	1.74223393
88	Hypergonadotropic hypogonadism (HP:0000815)	1.72814692
89	Pancytopenia (HP:0001876)	1.72603497
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.71017965
91	Abnormal protein glycosylation (HP:0012346)	1.71017965
92	Abnormal glycosylation (HP:0012345)	1.71017965
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71017965
94	Polygenic inheritance (HP:0010982)	1.70322115
95	Progressive external ophthalmoplegia (HP:0000590)	1.70003288
96	Abnormality of liposaccharide metabolism (HP:0010968)	1.69437566
97	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.69437566
98	Abnormality of glycolipid metabolism (HP:0010969)	1.69437566
99	Stridor (HP:0010307)	1.68761729
100	Premature skin wrinkling (HP:0100678)	1.68126539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.88379289
2	VRK2	3.78058723
3	SMG1	3.36483025
4	BUB1	3.32427235
5	TRIB3	2.90164497
6	IRAK3	2.87020791
7	TESK2	2.85682032
8	NEK1	2.36860101
9	MAP3K11	2.23975794
10	TESK1	2.16167733
11	ARAF	2.12682045
12	PBK	2.02682816
13	SCYL2	1.84935069
14	TAOK2	1.84502346
15	PIM2	1.81564392
16	MAP2K3	1.79632495
17	BCKDK	1.74166475
18	CDC7	1.71492279
19	ICK	1.67482170
20	PRPF4B	1.65264356
21	ERN1	1.65191625
22	STK16	1.60343933
23	KDR	1.56060190
24	EPHA2	1.39096831
25	BRAF	1.38223214
26	PAK4	1.37776154
27	SIK1	1.32680230
28	AURKA	1.32071538
29	LIMK1	1.27330565
30	SRPK1	1.25743405
31	CDK7	1.21424955
32	ABL2	1.16624504
33	MAP3K10	1.15218208
34	EEF2K	1.13956109
35	MAP3K8	1.13823126
36	DAPK1	1.11372973
37	CDK8	1.10150944
38	EIF2AK1	1.01942321
39	RPS6KB2	1.00384297
40	TAOK1	0.97308089
41	IRAK2	0.96978644
42	ILK	0.95286620
43	CHEK2	0.93883498
44	TAF1	0.93301364
45	MAP2K2	0.85815407
46	TTK	0.85353511
47	CDK4	0.84908376
48	LRRK2	0.84125637
49	RPS6KA4	0.83498759
50	CDK19	0.82130895
51	MAP3K3	0.81389342
52	BRSK1	0.80574658
53	NME1	0.78048660
54	PRKD3	0.77974904
55	PAK1	0.74381702
56	VRK1	0.74055748
57	PKN2	0.73853624
58	LMTK2	0.73343851
59	CSNK1G3	0.71976685
60	PLK1	0.69745810
61	ATR	0.69141655
62	STK4	0.69108761
63	AURKB	0.68327976
64	PRKCI	0.60972013
65	STK10	0.59640224
66	BMX	0.57165360
67	PTK6	0.56124000
68	GRK6	0.55812414
69	TTN	0.55179942
70	DAPK3	0.53849020
71	CDK12	0.53598733
72	IRAK4	0.51881455
73	RPS6KA2	0.51485829
74	PTK2	0.51137481
75	RPS6KL1	0.50968455
76	RPS6KC1	0.50968455
77	CHEK1	0.50062608
78	CDK11A	0.47419900
79	CSNK1A1L	0.45746367
80	MST1R	0.45417099
81	ZAK	0.44852905
82	NEK2	0.43990782
83	AKT2	0.43489201
84	PDPK1	0.42395233
85	TBK1	0.41980511
86	CDK14	0.41445144
87	MAP3K1	0.40462172
88	MTOR	0.40107864
89	CDK15	0.39892383
90	MAPK11	0.37021722
91	DYRK3	0.36772284
92	PRKG2	0.35494057
93	CDK18	0.35252112
94	CSNK2A2	0.34868173
95	ALK	0.34732719
96	LATS2	0.33920877
97	CDK9	0.33804130
98	MAP2K7	0.33151509
99	CSNK1G1	0.32912425
100	RPS6KA1	0.31701672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.63413176
2	Ribosome_Homo sapiens_hsa03010	3.86106022
3	Base excision repair_Homo sapiens_hsa03410	3.37317132
4	Proteasome_Homo sapiens_hsa03050	3.10841172
5	Sulfur relay system_Homo sapiens_hsa04122	2.94612766
6	Mismatch repair_Homo sapiens_hsa03430	2.71727625
7	Pyrimidine metabolism_Homo sapiens_hsa00240	2.46770127
8	RNA polymerase_Homo sapiens_hsa03020	2.32264504
9	Pentose phosphate pathway_Homo sapiens_hsa00030	2.31406786
10	Spliceosome_Homo sapiens_hsa03040	2.24390989
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17189238
12	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.16741625
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.07430263
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.01132919
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.90507869
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.80639788
17	Parkinsons disease_Homo sapiens_hsa05012	1.71012013
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68866964
19	Carbon metabolism_Homo sapiens_hsa01200	1.63756348
20	RNA transport_Homo sapiens_hsa03013	1.61221256
21	Cell cycle_Homo sapiens_hsa04110	1.58032941
22	Homologous recombination_Homo sapiens_hsa03440	1.57116776
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.53705337
24	Galactose metabolism_Homo sapiens_hsa00052	1.52847270
25	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.52445206
26	Fatty acid elongation_Homo sapiens_hsa00062	1.42711520
27	One carbon pool by folate_Homo sapiens_hsa00670	1.40027168
28	Huntingtons disease_Homo sapiens_hsa05016	1.37276175
29	Folate biosynthesis_Homo sapiens_hsa00790	1.28698368
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.22937566
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21418692
32	Purine metabolism_Homo sapiens_hsa00230	1.13686208
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.12955443
34	Glutathione metabolism_Homo sapiens_hsa00480	1.09040176
35	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.08466864
36	Bladder cancer_Homo sapiens_hsa05219	1.07890455
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07550435
38	Other glycan degradation_Homo sapiens_hsa00511	1.05766968
39	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.04011051
40	Vibrio cholerae infection_Homo sapiens_hsa05110	1.03967661
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.00326906
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98644616
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98011682
44	Non-homologous end-joining_Homo sapiens_hsa03450	0.97602248
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94025059
46	Alzheimers disease_Homo sapiens_hsa05010	0.94008150
47	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.93175211
48	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.90245524
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89312584
50	Shigellosis_Homo sapiens_hsa05131	0.88173156
51	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.86594913
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84493523
53	Acute myeloid leukemia_Homo sapiens_hsa05221	0.82375586
54	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.79914651
55	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.77710505
56	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.75647957
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73208266
58	Thyroid cancer_Homo sapiens_hsa05216	0.68561218
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64630829
60	Non-small cell lung cancer_Homo sapiens_hsa05223	0.63755199
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61940595
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.61585904
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.61557085
64	Lysosome_Homo sapiens_hsa04142	0.58815442
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58474502
66	Pancreatic cancer_Homo sapiens_hsa05212	0.57756248
67	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.57698027
68	Notch signaling pathway_Homo sapiens_hsa04330	0.57048525
69	p53 signaling pathway_Homo sapiens_hsa04115	0.56193350
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.56059666
71	HTLV-I infection_Homo sapiens_hsa05166	0.55813807
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.54378371
73	Apoptosis_Homo sapiens_hsa04210	0.54330418
74	Viral carcinogenesis_Homo sapiens_hsa05203	0.53687600
75	Metabolic pathways_Homo sapiens_hsa01100	0.52692965
76	Herpes simplex infection_Homo sapiens_hsa05168	0.48245618
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47074527
78	Salmonella infection_Homo sapiens_hsa05132	0.43777561
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43541599
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40205227
81	VEGF signaling pathway_Homo sapiens_hsa04370	0.39647876
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34866063
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34158815
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33233611
85	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.33137949
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32495802
87	RNA degradation_Homo sapiens_hsa03018	0.31459005
88	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.30627964
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.29300172
90	Alcoholism_Homo sapiens_hsa05034	0.29178594
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.25850155
92	Colorectal cancer_Homo sapiens_hsa05210	0.25729881
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24570553
94	Hepatitis B_Homo sapiens_hsa05161	0.24136552
95	Endocytosis_Homo sapiens_hsa04144	0.22805494
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22033776
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.21635493
98	Oocyte meiosis_Homo sapiens_hsa04114	0.20866847
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20106840
100	Viral myocarditis_Homo sapiens_hsa05416	0.18736015

C20ORF27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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