ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.35313695
2	primary alcohol catabolic process (GO:0034310)	7.96709076
3	regulation of cilium movement (GO:0003352)	7.77117409
4	vitamin transmembrane transport (GO:0035461)	7.04795781
5	left/right axis specification (GO:0070986)	6.86611074
6	ventricular system development (GO:0021591)	6.71604141
7	ethanol metabolic process (GO:0006067)	6.63312341
8	microtubule bundle formation (GO:0001578)	6.44704420
9	diterpenoid biosynthetic process (GO:0016102)	6.29388365
10	intraciliary transport (GO:0042073)	6.20845130
11	cilium organization (GO:0044782)	5.85441648
12	cilium assembly (GO:0042384)	5.68770953
13	tolerance induction (GO:0002507)	5.60475302
14	pyrimidine-containing compound transmembrane transport (GO:0072531)	5.50398034
15	response to xenobiotic stimulus (GO:0009410)	5.47860893
16	one-carbon compound transport (GO:0019755)	5.34753429
17	lung epithelium development (GO:0060428)	5.27577021
18	centriole assembly (GO:0098534)	5.16470591
19	ethanol oxidation (GO:0006069)	5.00693875
20	establishment of apical/basal cell polarity (GO:0035089)	4.98407537
21	negative regulation of T cell differentiation in thymus (GO:0033085)	4.95925388
22	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.86597267
23	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.85708322
24	negative regulation of B cell mediated immunity (GO:0002713)	4.85708322
25	protein localization to cilium (GO:0061512)	4.83748435
26	glomerular epithelial cell development (GO:0072310)	4.82561850
27	sperm capacitation (GO:0048240)	4.76335121
28	regulation of interleukin-5 production (GO:0032674)	4.66089747
29	negative regulation of humoral immune response (GO:0002921)	4.63371891
30	microtubule-based movement (GO:0007018)	4.60805504
31	regulation of microtubule-based movement (GO:0060632)	4.51932430
32	cellular component assembly involved in morphogenesis (GO:0010927)	4.50608952
33	regulation of germinal center formation (GO:0002634)	4.49698685
34	positive regulation of tolerance induction (GO:0002645)	4.49399928
35	terpenoid biosynthetic process (GO:0016114)	4.37814298
36	establishment of monopolar cell polarity (GO:0061162)	4.30967243
37	establishment or maintenance of monopolar cell polarity (GO:0061339)	4.30967243
38	regulation of interleukin-13 production (GO:0032656)	4.29180998
39	retinoic acid metabolic process (GO:0042573)	4.25179535
40	cell projection assembly (GO:0030031)	4.17533388
41	cilium morphogenesis (GO:0060271)	4.09490507
42	nucleoside diphosphate phosphorylation (GO:0006165)	3.92870817
43	cytoplasmic microtubule organization (GO:0031122)	3.85586446
44	negative regulation of inclusion body assembly (GO:0090084)	3.76627738
45	microtubule depolymerization (GO:0007019)	3.64218661
46	exogenous drug catabolic process (GO:0042738)	3.55203376
47	primary alcohol metabolic process (GO:0034308)	3.50059229
48	microtubule polymerization or depolymerization (GO:0031109)	3.46533823
49	establishment of tissue polarity (GO:0007164)	3.43644211
50	establishment of planar polarity (GO:0001736)	3.43644211
51	regulation of tolerance induction (GO:0002643)	3.39578018
52	retinol metabolic process (GO:0042572)	3.38338063
53	lateral ventricle development (GO:0021670)	3.33958767
54	O-glycan processing (GO:0016266)	3.30113542
55	glutathione derivative biosynthetic process (GO:1901687)	3.23534230
56	glutathione derivative metabolic process (GO:1901685)	3.23534230
57	hydrogen peroxide biosynthetic process (GO:0050665)	3.18009027
58	positive regulation of smoothened signaling pathway (GO:0045880)	3.13400608
59	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.08106350
60	aldehyde catabolic process (GO:0046185)	3.07353289
61	multicellular organismal water homeostasis (GO:0050891)	3.06743997
62	regulation of microtubule depolymerization (GO:0031114)	3.04879333
63	axonemal dynein complex assembly (GO:0070286)	22.2246259
64	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.96783916
65	reactive oxygen species biosynthetic process (GO:1903409)	2.82791608
66	carnitine metabolic process (GO:0009437)	2.82749303
67	progesterone metabolic process (GO:0042448)	2.82712327
68	lateral sprouting from an epithelium (GO:0060601)	2.81117445
69	apical protein localization (GO:0045176)	2.80608727
70	hydrogen peroxide catabolic process (GO:0042744)	2.78546184
71	sperm motility (GO:0030317)	2.77084420
72	hypotonic response (GO:0006971)	2.74783334
73	determination of left/right symmetry (GO:0007368)	2.73625175
74	drug catabolic process (GO:0042737)	2.71589980
75	microtubule-based process (GO:0007017)	2.71338380
76	oligosaccharide biosynthetic process (GO:0009312)	2.67644061
77	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.65832539
78	regulation of response to osmotic stress (GO:0047484)	2.64991989
79	excretion (GO:0007588)	2.64965128
80	centriole replication (GO:0007099)	2.64495956
81	regulation of autophagic vacuole assembly (GO:2000785)	2.63172721
82	determination of bilateral symmetry (GO:0009855)	2.62813436
83	water homeostasis (GO:0030104)	2.60989931
84	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.59436477
85	phosphatidylcholine biosynthetic process (GO:0006656)	2.58685854
86	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	2.57884982
87	specification of symmetry (GO:0009799)	2.57301534
88	smoothened signaling pathway (GO:0007224)	2.54021692
89	organelle assembly (GO:0070925)	2.51220932
90	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.50497024
91	iron ion import (GO:0097286)	2.47138589
92	polyol transport (GO:0015791)	2.46564134
93	negative regulation of microtubule depolymerization (GO:0007026)	2.46229772
94	sodium ion homeostasis (GO:0055078)	2.45290740
95	cilium or flagellum-dependent cell motility (GO:0001539)	18.0078593
96	cilium movement (GO:0003341)	15.7052606
97	motile cilium assembly (GO:0044458)	15.1388195
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.1610566
99	epithelial cilium movement (GO:0003351)	13.5866115
100	axoneme assembly (GO:0035082)	10.1403001

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.14814101
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.78640941
3	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.57891679
4	DROSHA_22980978_ChIP-Seq_HELA_Human	3.35019964
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.21768052
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.87959550
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.47171522
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.38232656
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.21973699
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.10746356
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.08457420
12	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.04154903
13	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.03339427
14	AHR_22903824_ChIP-Seq_MCF-7_Human	1.93852030
15	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.93507849
16	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.92547931
17	STAT1_20625510_ChIP-Seq_HELA_Human	1.89421597
18	* SMC4_20622854_ChIP-Seq_HELA_Human	1.82780521
19	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.63980413
20	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.63401167
21	TP63_23658742_ChIP-Seq_EP156T_Human	1.63203218
22	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.62388848
23	KLF5_25053715_ChIP-Seq_YYC3_Human	1.60608460
24	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.59898994
25	TP63_22573176_ChIP-Seq_HFKS_Human	1.58333160
26	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57525633
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57290723
28	SOX2_20726797_ChIP-Seq_SW620_Human	1.57188038
29	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.55114812
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55082832
31	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.52844170
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.52785896
33	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.51879225
34	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.51652969
35	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.48759956
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48644071
37	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.48114902
38	GATA1_19941826_ChIP-Seq_K562_Human	1.43927388
39	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.42077686
40	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.41414550
41	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.41351694
42	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.41031104
43	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.39862613
44	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33590638
45	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.33534360
46	RACK7_27058665_Chip-Seq_MCF-7_Human	1.27780665
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26834997
48	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.24642615
49	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.24103476
50	TP53_18474530_ChIP-ChIP_U2OS_Human	1.23489266
51	VDR_22108803_ChIP-Seq_LS180_Human	1.22529360
52	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.21224171
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.21189750
54	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.20766330
55	PHF8_20622853_ChIP-Seq_HELA_Human	1.20477294
56	CTCF_27219007_Chip-Seq_Bcells_Human	1.20474435
57	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.17777292
58	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.17671209
59	CREB1_26743006_Chip-Seq_LNCaP_Human	1.17580761
60	* SMRT_27268052_Chip-Seq_Bcells_Human	1.17177858
61	GATA4_25053715_ChIP-Seq_YYC3_Human	1.16895678
62	* P68_20966046_ChIP-Seq_HELA_Human	1.12826444
63	RBPJ_21746931_ChIP-Seq_IB4_Human	1.10763847
64	PHF8_20622854_ChIP-Seq_HELA_Human	1.10651241
65	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.09192659
66	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.08445382
67	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.07859496
68	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.06738720
69	ZNF263_19887448_ChIP-Seq_K562_Human	1.06271982
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05971416
71	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.05882483
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.05704418
73	* CDX2_20551321_ChIP-Seq_CACO-2_Human	1.05698857
74	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.05636356
75	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.03251505
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02908306
77	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02541731
78	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01383972
79	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.98924890
80	P300_27268052_Chip-Seq_Bcells_Human	0.98722388
81	CEBPB_22108803_ChIP-Seq_LS180_Human	0.98092974
82	LXR_22292898_ChIP-Seq_THP-1_Human	0.97803630
83	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.97709688
84	NFYA_21822215_ChIP-Seq_K562_Human	0.95563412
85	GATA2_19941826_ChIP-Seq_K562_Human	0.94607390
86	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.92196708
87	SOX2_21211035_ChIP-Seq_LN229_Human	0.92146082
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90317282
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89671659
90	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.89277769
91	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.88783304
92	E2F1_20622854_ChIP-Seq_HELA_Human	0.88600928
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.86562955
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86300698
95	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.86005106
96	NFYB_21822215_ChIP-Seq_K562_Human	0.85963373
97	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.84685068
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.83863425
99	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83334649
100	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.83301148

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	7.37780888
2	MP0002653_abnormal_ependyma_morphology	6.27642477
3	MP0002132_abnormal_respiratory_system	5.88247687
4	MP0004043_abnormal_pH_regulation	4.06271391
5	MP0002277_abnormal_respiratory_mucosa	3.98103542
6	MP0001984_abnormal_olfaction	3.97736732
7	MP0009780_abnormal_chondrocyte_physiolo	3.97607374
8	MP0005623_abnormal_meninges_morphology	3.47456046
9	MP0004133_heterotaxia	3.47196317
10	MP0008789_abnormal_olfactory_epithelium	3.25210142
11	MP0000566_synostosis	2.72015378
12	MP0000383_abnormal_hair_follicle	2.24573340
13	MP0004019_abnormal_vitamin_homeostasis	2.17089435
14	MP0005499_abnormal_olfactory_system	2.12248745
15	MP0005394_taste/olfaction_phenotype	2.12248745
16	MP0003878_abnormal_ear_physiology	2.11753213
17	MP0005377_hearing/vestibular/ear_phenot	2.11753213
18	MP0002168_other_aberrant_phenotype	2.08640946
19	MP0003656_abnormal_erythrocyte_physiolo	2.05963926
20	MP0010678_abnormal_skin_adnexa	2.05906177
21	MP0002282_abnormal_trachea_morphology	1.96465996
22	MP0005083_abnormal_biliary_tract	1.96445359
23	MP0001765_abnormal_ion_homeostasis	1.83186788
24	MP0002160_abnormal_reproductive_system	1.76945156
25	MP0010234_abnormal_vibrissa_follicle	1.70645818
26	MP0000678_abnormal_parathyroid_gland	1.69898980
27	MP0001346_abnormal_lacrimal_gland	1.55793978
28	MP0002909_abnormal_adrenal_gland	1.53855253
29	MP0005165_increased_susceptibility_to	1.47790890
30	MP0010155_abnormal_intestine_physiology	1.39428166
31	MP0009379_abnormal_foot_pigmentation	1.35157323
32	MP0000465_gastrointestinal_hemorrhage	1.31521029
33	MP0005395_other_phenotype	1.30766761
34	MP0002249_abnormal_larynx_morphology	1.30196777
35	MP0005248_abnormal_Harderian_gland	1.26056931
36	MP0005636_abnormal_mineral_homeostasis	1.24717487
37	MP0003303_peritoneal_inflammation	1.17738472
38	MP0004264_abnormal_extraembryonic_tissu	1.06594590
39	MP0010030_abnormal_orbit_morphology	1.00453709
40	MP0001849_ear_inflammation	0.99938388
41	MP0005164_abnormal_response_to	0.99542706
42	MP0002233_abnormal_nose_morphology	0.97769732
43	MP0002734_abnormal_mechanical_nocicepti	0.97343920
44	MP0002876_abnormal_thyroid_physiology	0.95784370
45	MP0005408_hypopigmentation	0.95245434
46	MP0000681_abnormal_thyroid_gland	0.95109111
47	MP0004883_abnormal_blood_vessel	0.89613200
48	MP0009643_abnormal_urine_homeostasis	0.89283911
49	MP0003453_abnormal_keratinocyte_physiol	0.85955361
50	MP0005365_abnormal_bile_salt	0.85143997
51	MP0002136_abnormal_kidney_physiology	0.83436915
52	MP0005389_reproductive_system_phenotype	0.79100801
53	MP0002098_abnormal_vibrissa_morphology	0.77711544
54	MP0002638_abnormal_pupillary_reflex	0.77006517
55	MP0002735_abnormal_chemical_nociception	0.76715088
56	MP0000858_altered_metastatic_potential	0.75073326
57	MP0003075_altered_response_to	0.74152278
58	MP0002405_respiratory_system_inflammati	0.73573997
59	MP0002139_abnormal_hepatobiliary_system	0.73425331
60	MP0001485_abnormal_pinna_reflex	0.70891809
61	MP0009765_abnormal_xenobiotic_induced	0.70285572
62	MP0005310_abnormal_salivary_gland	0.69403376
63	MP0005220_abnormal_exocrine_pancreas	0.69212506
64	MP0000467_abnormal_esophagus_morphology	0.68392322
65	MP0001929_abnormal_gametogenesis	0.68121488
66	MP0005085_abnormal_gallbladder_physiolo	0.66763566
67	MP0009763_increased_sensitivity_to	0.64691396
68	MP0003866_abnormal_defecation	0.62441624
69	MP0003698_abnormal_male_reproductive	0.61757334
70	MP0006082_CNS_inflammation	0.61416872
71	MP0005409_darkened_coat_color	0.60635123
72	MP0005503_abnormal_tendon_morphology	0.57760568
73	MP0009703_decreased_birth_body	0.56424631
74	MP0001270_distended_abdomen	0.56213268
75	MP0005023_abnormal_wound_healing	0.55731500
76	MP0005387_immune_system_phenotype	0.53021654
77	MP0001790_abnormal_immune_system	0.53021654
78	MP0001293_anophthalmia	0.53004482
79	MP0002133_abnormal_respiratory_system	0.51907789
80	MP0005388_respiratory_system_phenotype	0.51907789
81	MP0002896_abnormal_bone_mineralization	0.51280258
82	MP0001663_abnormal_digestive_system	0.50876780
83	MP0003806_abnormal_nucleotide_metabolis	0.49500200
84	MP0003136_yellow_coat_color	0.49431401
85	MP0001664_abnormal_digestion	0.47490321
86	MP0005166_decreased_susceptibility_to	0.46994290
87	MP0001944_abnormal_pancreas_morphology	0.46507522
88	MP0009046_muscle_twitch	0.45786487
89	MP0001324_abnormal_eye_pigmentation	0.44374170
90	MP0002116_abnormal_craniofacial_bone	0.44224039
91	MP0000026_abnormal_inner_ear	0.43877974
92	MP0001502_abnormal_circadian_rhythm	0.43511552
93	MP0001666_abnormal_nutrient_absorption	0.41755275
94	MP0001299_abnormal_eye_distance/	0.41567960
95	MP0003191_abnormal_cellular_cholesterol	0.41197657
96	MP0003950_abnormal_plasma_membrane	0.41181773
97	MP0006036_abnormal_mitochondrial_physio	0.41107060
98	MP0002135_abnormal_kidney_morphology	0.40144436
99	MP0002084_abnormal_developmental_patter	0.39692624
100	MP0001879_abnormal_lymphatic_vessel	0.38216021

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	8.12974294
2	Bronchiectasis (HP:0002110)	7.55135229
3	Nasal polyposis (HP:0100582)	6.96018449
4	Abnormality of the nasal mucosa (HP:0000433)	5.80889910
5	Recurrent sinusitis (HP:0011108)	4.48537833
6	Bronchitis (HP:0012387)	4.46686628
7	Infertility (HP:0000789)	4.30810606
8	Chronic sinusitis (HP:0011109)	4.16603253
9	Male infertility (HP:0003251)	4.02923318
10	Recurrent otitis media (HP:0000403)	3.98448354
11	Occipital encephalocele (HP:0002085)	3.54004531
12	Pancreatic fibrosis (HP:0100732)	3.28549239
13	True hermaphroditism (HP:0010459)	3.23301921
14	Hyperactive renin-angiotensin system (HP:0000841)	3.13804268
15	Chronic otitis media (HP:0000389)	3.13050355
16	Atelectasis (HP:0100750)	3.10932225
17	Cystic liver disease (HP:0006706)	2.73531477
18	Abnormality of midbrain morphology (HP:0002418)	2.62568477
19	Molar tooth sign on MRI (HP:0002419)	2.62568477
20	Pancreatic cysts (HP:0001737)	2.61292688
21	Nephronophthisis (HP:0000090)	2.53444384
22	Postaxial foot polydactyly (HP:0001830)	2.32149404
23	Chronic hepatic failure (HP:0100626)	2.27729183
24	Tubulointerstitial nephritis (HP:0001970)	2.08496070
25	Bell-shaped thorax (HP:0001591)	2.06161040
26	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.6736546
27	Abnormal respiratory motile cilium morphology (HP:0005938)	11.3478195
28	Abnormal respiratory epithelium morphology (HP:0012253)	11.3478195
29	Abnormal respiratory motile cilium physiology (HP:0012261)	11.1383540
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.9371378
31	Absent/shortened dynein arms (HP:0200106)	10.9371378
32	Abnormal ciliary motility (HP:0012262)	10.8401631
33	Rhinitis (HP:0012384)	10.3452406
34	Abnormality of the renal medulla (HP:0100957)	1.95843780
35	Absent frontal sinuses (HP:0002688)	1.95500442
36	Recurrent bronchitis (HP:0002837)	1.94863857
37	Congenital hepatic fibrosis (HP:0002612)	1.93091231
38	Renal salt wasting (HP:0000127)	1.90049164
39	Anencephaly (HP:0002323)	1.89062470
40	Decreased circulating renin level (HP:0003351)	1.85021946
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84539469
42	Male pseudohermaphroditism (HP:0000037)	1.81016516
43	Asplenia (HP:0001746)	1.70664585
44	Medial flaring of the eyebrow (HP:0010747)	1.69747348
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69536182
46	Hyperkalemia (HP:0002153)	1.66785083
47	Nephropathy (HP:0000112)	1.61716666
48	Congenital primary aphakia (HP:0007707)	1.59240239
49	Oculomotor apraxia (HP:0000657)	1.57970452
50	Furrowed tongue (HP:0000221)	1.57795461
51	Gait imbalance (HP:0002141)	1.55940943
52	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.54223783
53	Sclerocornea (HP:0000647)	1.53489295
54	Hyperaldosteronism (HP:0000859)	1.53073166
55	Tubular atrophy (HP:0000092)	1.51569858
56	Postaxial hand polydactyly (HP:0001162)	1.44705014
57	Abnormality of chloride homeostasis (HP:0011422)	1.40130747
58	Abnormality of renin-angiotensin system (HP:0000847)	1.38863361
59	Nephrogenic diabetes insipidus (HP:0009806)	1.37227758
60	Abnormality of the distal phalanges of the toes (HP:0010182)	1.32176617
61	Hand muscle atrophy (HP:0009130)	1.29450809
62	Hypokalemic alkalosis (HP:0001949)	1.27494514
63	Glucose intolerance (HP:0000833)	1.27076565
64	Median cleft lip (HP:0000161)	1.26050936
65	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.23686012
66	Short thorax (HP:0010306)	1.23563771
67	Abnormality of the frontal sinuses (HP:0002687)	1.22264142
68	Short nail (HP:0001799)	1.21535837
69	Abnormality of the dental root (HP:0006486)	1.20427416
70	Taurodontia (HP:0000679)	1.20427416
71	Abnormality of permanent molar morphology (HP:0011071)	1.20427416
72	Preaxial hand polydactyly (HP:0001177)	1.19990678
73	Hyponatremia (HP:0002902)	1.19940701
74	Bifid scrotum (HP:0000048)	1.19693649
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.15592765
76	Fetal akinesia sequence (HP:0001989)	1.14546669
77	Tubulointerstitial abnormality (HP:0001969)	1.14253515
78	Obstructive sleep apnea (HP:0002870)	1.12972064
79	Cone-rod dystrophy (HP:0000548)	1.12163957
80	Abnormality of molar (HP:0011077)	1.10815510
81	Abnormality of molar morphology (HP:0011070)	1.10815510
82	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.10342490
83	Stage 5 chronic kidney disease (HP:0003774)	1.08508881
84	Poor coordination (HP:0002370)	1.07800141
85	Decreased central vision (HP:0007663)	1.07013521
86	Abnormality of the dental pulp (HP:0006479)	1.06398751
87	Muscle fiber splitting (HP:0003555)	1.05838559
88	Popliteal pterygium (HP:0009756)	1.05700278
89	Aplasia of the musculature (HP:0100854)	1.05005241
90	Flat acetabular roof (HP:0003180)	1.04838902
91	Short femoral neck (HP:0100864)	1.04759245
92	Vaginal atresia (HP:0000148)	1.04588693
93	Genital tract atresia (HP:0001827)	1.03482189
94	Lip pit (HP:0100267)	1.01006328
95	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.00431473
96	Spinal muscular atrophy (HP:0007269)	0.98786452
97	Limb-girdle muscle atrophy (HP:0003797)	0.96295811
98	Abnormality of dentin (HP:0010299)	0.95476111
99	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	0.94412936
100	Carpal bone hypoplasia (HP:0001498)	0.94082227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.77006934
2	EPHA2	5.10444504
3	SMG1	2.47527020
4	MAPKAPK3	2.43372493
5	NME1	2.29008761
6	MAP3K2	2.15043599
7	STK24	2.04492867
8	MAPK15	11.8312777
9	EEF2K	1.87894553
10	TTK	1.87468506
11	MAP3K3	1.77371610
12	CSK	1.60338234
13	PTK2B	1.35162587
14	BCR	1.32273778
15	LRRK2	1.31833658
16	EPHB1	1.28192759
17	STK10	1.25498380
18	NEK6	1.17282323
19	MST1R	1.15676995
20	RIPK4	1.10269819
21	TESK1	1.08902682
22	TRPM7	1.02033274
23	PNCK	0.97639403
24	TBK1	0.96318811
25	MAP3K7	0.95678665
26	MARK2	0.93423997
27	TLK1	0.91314352
28	EPHA3	0.83979071
29	PRKCI	0.82403031
30	ICK	0.80547291
31	MAP3K12	0.78698915
32	TRIB3	0.74539529
33	CAMKK1	0.71297927
34	STK38	0.70307800
35	ERBB3	0.70251050
36	ERBB2	0.63843638
37	RIPK1	0.58027575
38	GRK6	0.55533796
39	BRSK2	0.51447598
40	CAMK2G	0.48984807
41	RPS6KB2	0.46945004
42	STK16	0.46703342
43	PRKCD	0.46590927
44	AURKA	0.45306057
45	PRKCQ	0.44864395
46	PBK	0.43649359
47	PAK4	0.42585193
48	HIPK2	0.41549109
49	PDPK1	0.40712565
50	TAOK1	0.40271401
51	DYRK1B	0.39818011
52	SGK1	0.38918770
53	TSSK6	0.37599684
54	PRKAA2	0.37528247
55	NLK	0.35492504
56	CDC42BPA	0.33586230
57	IRAK1	0.33436595
58	ROCK2	0.30150731
59	MAP3K4	0.29635828
60	FGFR3	0.29611096
61	ZAP70	0.27338875
62	FER	0.25984649
63	CDK6	0.25567932
64	MAP2K4	0.24808411
65	PTK6	0.24002279
66	LATS1	0.23832674
67	MAPKAPK5	0.22777338
68	AKT2	0.22711234
69	LMTK2	0.22576851
70	MAP2K2	0.22327611
71	ABL1	0.22101416
72	MYLK	0.21939189
73	TYK2	0.21027951
74	STK38L	0.20565815
75	ROCK1	0.19361186
76	NEK9	0.19192640
77	MET	0.19137448
78	FYN	0.18887243
79	PRKCA	0.18321855
80	PRKACA	0.18100218
81	PAK1	0.17728967
82	RPS6KA2	0.16794882
83	PLK1	0.16321422
84	SRC	0.16082818
85	ADRBK1	0.14816690
86	MAP2K7	0.14077038
87	MATK	0.14015081
88	ILK	0.14001742
89	PIM2	0.13854004
90	DYRK1A	0.13588733
91	EGFR	0.12707607
92	PASK	0.12349152
93	RET	0.12141581
94	MAP3K6	0.10300418
95	BMPR2	0.09024780
96	MAP3K8	0.08789859
97	PRKDC	0.08743968
98	OXSR1	0.08726778
99	ABL2	0.08124744
100	INSRR	0.07949604

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.88086936
2	Phenylalanine metabolism_Homo sapiens_hsa00360	5.28703589
3	Histidine metabolism_Homo sapiens_hsa00340	4.81845222
4	Chemical carcinogenesis_Homo sapiens_hsa05204	4.69642357
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.40209800
6	Tyrosine metabolism_Homo sapiens_hsa00350	4.12705671
7	beta-Alanine metabolism_Homo sapiens_hsa00410	3.11785427
8	Glutathione metabolism_Homo sapiens_hsa00480	2.82042472
9	Huntingtons disease_Homo sapiens_hsa05016	2.61465396
10	Retinol metabolism_Homo sapiens_hsa00830	2.35662640
11	Caffeine metabolism_Homo sapiens_hsa00232	2.31500147
12	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.88601247
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.82390651
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.81327086
15	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.70127937
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.65734972
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65299162
18	Sphingolipid metabolism_Homo sapiens_hsa00600	1.62762089
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.57225810
20	Tight junction_Homo sapiens_hsa04530	1.43956504
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39228600
22	Fatty acid degradation_Homo sapiens_hsa00071	1.29172971
23	ABC transporters_Homo sapiens_hsa02010	1.15240407
24	Peroxisome_Homo sapiens_hsa04146	1.05205456
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95996169
26	Salivary secretion_Homo sapiens_hsa04970	0.95753950
27	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.94895253
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90063659
29	Circadian rhythm_Homo sapiens_hsa04710	0.83461902
30	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.82811750
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81926510
32	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.80994477
33	Hepatitis C_Homo sapiens_hsa05160	0.77363087
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76799728
35	Notch signaling pathway_Homo sapiens_hsa04330	0.75980833
36	Choline metabolism in cancer_Homo sapiens_hsa05231	0.67145681
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65484135
38	Adherens junction_Homo sapiens_hsa04520	0.62043336
39	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.54938309
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52732116
41	Complement and coagulation cascades_Homo sapiens_hsa04610	0.52206383
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51293535
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50691432
44	Taste transduction_Homo sapiens_hsa04742	0.49034098
45	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48514948
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46338137
47	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.44903145
48	PPAR signaling pathway_Homo sapiens_hsa03320	0.41461818
49	Olfactory transduction_Homo sapiens_hsa04740	0.40599334
50	Amoebiasis_Homo sapiens_hsa05146	0.39808948
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35354526
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34912391
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34547480
54	Lysosome_Homo sapiens_hsa04142	0.34079883
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.33051837
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32611571
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32429697
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.29982149
59	Cocaine addiction_Homo sapiens_hsa05030	0.27031722
60	Metabolic pathways_Homo sapiens_hsa01100	0.25469326
61	Allograft rejection_Homo sapiens_hsa05330	0.24912433
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.24658996
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24487319
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.24163001
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.23572439
66	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.23004177
67	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.22917818
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.22286264
69	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.21341903
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20668982
71	Insulin resistance_Homo sapiens_hsa04931	0.19804768
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.19508084
73	Phagosome_Homo sapiens_hsa04145	0.17558249
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.17343728
75	Antigen processing and presentation_Homo sapiens_hsa04612	0.16802102
76	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.16125741
77	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.15643415
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.15240364
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.15215880
80	Endocytosis_Homo sapiens_hsa04144	0.14876074
81	Asthma_Homo sapiens_hsa05310	0.13221352
82	Pancreatic secretion_Homo sapiens_hsa04972	0.12604879
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.12542170
84	Amphetamine addiction_Homo sapiens_hsa05031	0.11607484
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.10730993
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.10180857
87	Prostate cancer_Homo sapiens_hsa05215	0.10179958
88	Bile secretion_Homo sapiens_hsa04976	0.09967759
89	Serotonergic synapse_Homo sapiens_hsa04726	0.09738199
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.09535556
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.09512141
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.08242592
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.08220226
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.08038696
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.07806462
96	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.07755338
97	Nicotine addiction_Homo sapiens_hsa05033	0.07324653
98	Phototransduction_Homo sapiens_hsa04744	0.06242111
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.03370797
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.02954763

C20ORF85

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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