ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.19234556
2	DNA packaging (GO:0006323)	8.80348416
3	protein targeting to Golgi (GO:0000042)	8.68737490
4	sperm capacitation (GO:0048240)	8.67696071
5	microtubule depolymerization (GO:0007019)	8.32754017
6	plasma membrane fusion (GO:0045026)	8.30099434
7	establishment of protein localization to Golgi (GO:0072600)	8.30080673
8	retrograde transport, vesicle recycling within Golgi (GO:0000301)	8.13690879
9	protein polyglutamylation (GO:0018095)	7.62928490
10	microtubule polymerization or depolymerization (GO:0031109)	7.54951064
11	spermatid development (GO:0007286)	7.52310888
12	single strand break repair (GO:0000012)	7.30308020
13	rRNA methylation (GO:0031167)	7.24213558
14	spermatid nucleus differentiation (GO:0007289)	7.20054601
15	sperm-egg recognition (GO:0035036)	6.93376607
16	response to pheromone (GO:0019236)	6.77949013
17	centriole replication (GO:0007099)	6.68467560
18	spermatogenesis (GO:0007283)	6.44306896
19	multicellular organism reproduction (GO:0032504)	6.43369079
20	male gamete generation (GO:0048232)	6.42026408
21	calcium ion-dependent exocytosis (GO:0017156)	6.36691210
22	binding of sperm to zona pellucida (GO:0007339)	6.31140142
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.25835423
24	protein localization to Golgi apparatus (GO:0034067)	6.22039885
25	reproduction (GO:0000003)	6.13406172
26	sexual reproduction (GO:0019953)	6.11612612
27	axonemal dynein complex assembly (GO:0070286)	5.99989422
28	rRNA modification (GO:0000154)	5.99384130
29	negative regulation of inclusion body assembly (GO:0090084)	5.89392185
30	centriole assembly (GO:0098534)	5.89226807
31	gamete generation (GO:0007276)	5.89188897
32	seminiferous tubule development (GO:0072520)	5.88927685
33	phosphatidylethanolamine metabolic process (GO:0046337)	5.78732520
34	regulation of centriole replication (GO:0046599)	5.76091126
35	microtubule severing (GO:0051013)	5.74669899
36	cell-cell recognition (GO:0009988)	5.68322252
37	single fertilization (GO:0007338)	5.10923235
38	glomerular visceral epithelial cell development (GO:0072015)	5.00644170
39	RNA destabilization (GO:0050779)	5.00490178
40	regulation of Rab GTPase activity (GO:0032313)	4.97362445
41	positive regulation of Rab GTPase activity (GO:0032851)	4.97362445
42	motile cilium assembly (GO:0044458)	4.91689850
43	regulation of cilium movement (GO:0003352)	4.89713542
44	cilium or flagellum-dependent cell motility (GO:0001539)	4.88206996
45	multicellular organismal reproductive process (GO:0048609)	4.71381497
46	glomerular epithelial cell development (GO:0072310)	4.69366861
47	microtubule nucleation (GO:0007020)	4.58435248
48	fertilization (GO:0009566)	4.48755334
49	cell wall macromolecule catabolic process (GO:0016998)	4.47269611
50	nucleus organization (GO:0006997)	4.36485172
51	germ cell development (GO:0007281)	4.35508037
52	multicellular organismal movement (GO:0050879)	4.31657276
53	musculoskeletal movement (GO:0050881)	4.31657276
54	cell wall macromolecule metabolic process (GO:0044036)	4.28637044
55	epithelial cilium movement (GO:0003351)	4.21343918
56	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.20556754
57	nuclear pore complex assembly (GO:0051292)	4.19913212
58	regulation of inclusion body assembly (GO:0090083)	4.17827600
59	cellular ketone body metabolic process (GO:0046950)	4.13521118
60	regulation of transcription involved in cell fate commitment (GO:0060850)	4.11700802
61	chromatin silencing (GO:0006342)	4.02834049
62	glycerol ether metabolic process (GO:0006662)	3.84693014
63	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.79399478
64	cilium movement (GO:0003341)	3.72671906
65	ketone body metabolic process (GO:1902224)	3.70831110
66	ether metabolic process (GO:0018904)	3.53175069
67	membrane protein intracellular domain proteolysis (GO:0031293)	3.51763899
68	intra-Golgi vesicle-mediated transport (GO:0006891)	3.41407390
69	protein depolymerization (GO:0051261)	3.38214312
70	negative regulation of Rho protein signal transduction (GO:0035024)	3.23232768
71	Golgi to endosome transport (GO:0006895)	3.21396413
72	organic cation transport (GO:0015695)	3.20402422
73	histone H3-K9 demethylation (GO:0033169)	3.19707630
74	pore complex assembly (GO:0046931)	3.16385059
75	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.15551624
76	receptor recycling (GO:0001881)	3.14654799
77	regulation of microtubule-based movement (GO:0060632)	3.13479242
78	nuclear pore organization (GO:0006999)	3.13059481
79	regulation of interleukin-13 production (GO:0032656)	3.11638174
80	homeostasis of number of cells within a tissue (GO:0048873)	3.06111987
81	cerebral cortex neuron differentiation (GO:0021895)	3.02307099
82	coenzyme catabolic process (GO:0009109)	3.00259084
83	protein-DNA complex disassembly (GO:0032986)	2.99409203
84	nucleosome disassembly (GO:0006337)	2.99409203
85	vesicle transport along microtubule (GO:0047496)	2.99397484
86	RNA localization (GO:0006403)	2.97661345
87	cellular response to pH (GO:0071467)	2.96950258
88	ventricular system development (GO:0021591)	2.96499143
89	multicellular organismal development (GO:0007275)	2.95703190
90	regulation of T-helper 2 cell differentiation (GO:0045628)	2.93210951
91	polyamine biosynthetic process (GO:0006596)	2.92909640
92	mitotic G1 DNA damage checkpoint (GO:0031571)	2.88086512
93	response to acidic pH (GO:0010447)	2.85656089
94	centrosome duplication (GO:0051298)	2.84682061
95	regulation of ARF GTPase activity (GO:0032312)	2.80854542
96	cell recognition (GO:0008037)	2.78836757
97	DNA conformation change (GO:0071103)	2.78647998
98	sperm motility (GO:0030317)	11.8614813
99	acrosome reaction (GO:0007340)	11.1226563
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.9326959

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.43407849
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.91234800
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.76533403
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44654364
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.44654364
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.24219320
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.19817907
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.19817907
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.18595614
10	FUS_26573619_Chip-Seq_HEK293_Human	2.05157279
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.04681809
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00509597
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98319340
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90977979
15	RAC3_21632823_ChIP-Seq_H3396_Human	1.88131649
16	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.87086541
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.83011645
18	ERA_21632823_ChIP-Seq_H3396_Human	1.72320480
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.65803561
20	CTCF_27219007_Chip-Seq_Bcells_Human	1.65686857
21	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.61676140
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.61212695
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60213161
24	SMC4_20622854_ChIP-Seq_HELA_Human	1.57851396
25	MYC_19829295_ChIP-Seq_ESCs_Human	1.54761104
26	NANOG_20526341_ChIP-Seq_ESCs_Human	1.53554189
27	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.51777580
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.51003604
29	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.50980977
30	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.50795357
31	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.49498974
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.48229693
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.44928746
34	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.44650541
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43480732
36	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.42840003
37	RBPJ_21746931_ChIP-Seq_IB4_Human	1.41432796
38	TP63_22573176_ChIP-Seq_HFKS_Human	1.40699965
39	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40516934
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.39641484
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39284239
42	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.39221713
43	P68_20966046_ChIP-Seq_HELA_Human	1.38248106
44	BCOR_27268052_Chip-Seq_Bcells_Human	1.36248232
45	ETV1_20927104_ChIP-Seq_GIST48_Human	1.35521837
46	TP53_18474530_ChIP-ChIP_U2OS_Human	1.34969171
47	LXR_22292898_ChIP-Seq_THP-1_Human	1.34055411
48	CTCF_20526341_ChIP-Seq_ESCs_Human	1.33668051
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33378781
50	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31863873
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31298923
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31025983
53	E2F1_20622854_ChIP-Seq_HELA_Human	1.30789243
54	AR_25329375_ChIP-Seq_VCAP_Human	1.29981827
55	NFYB_21822215_ChIP-Seq_K562_Human	1.29431384
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.28032316
57	PHF8_20622854_ChIP-Seq_HELA_Human	1.28017648
58	TBL1_22424771_ChIP-Seq_293T_Human	1.27186880
59	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.24397895
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23555007
61	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23413180
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21667924
63	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.19841329
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.19702384
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19624555
66	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.18841515
67	PHF8_20622853_ChIP-Seq_HELA_Human	1.18398908
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17659818
69	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.14714095
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13746751
71	P300_19829295_ChIP-Seq_ESCs_Human	1.13726936
72	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.13720651
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13400567
74	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.12394776
75	P300_27268052_Chip-Seq_Bcells_Human	1.12058054
76	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.10801629
77	RUNX_20019798_ChIP-Seq_JUKART_Human	1.10494607
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09553612
79	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.08657624
80	SA1_27219007_Chip-Seq_Bcells_Human	1.08140957
81	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08083910
82	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07716586
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06041613
84	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05839889
85	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05231256
86	NFYA_21822215_ChIP-Seq_K562_Human	1.04446999
87	STAT3_23295773_ChIP-Seq_U87_Human	1.03891757
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03140318
89	KLF5_25053715_ChIP-Seq_YYC3_Human	1.02649012
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02403503
91	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00879474
92	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00559060
93	KLF4_19829295_ChIP-Seq_ESCs_Human	0.99715538
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.99130347
95	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.98475711
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98466944
97	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97996145
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.96929298
99	GF1_26923725_Chip-Seq_HPCs_Mouse	0.96357775
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.96148458

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	6.00372468
2	MP0003878_abnormal_ear_physiology	6.00372468
3	MP0005670_abnormal_white_adipose	4.87404509
4	MP0003698_abnormal_male_reproductive	4.24426724
5	MP0001348_abnormal_lacrimal_gland	3.82863677
6	MP0001929_abnormal_gametogenesis	3.69514729
7	MP0005451_abnormal_body_composition	2.46742258
8	MP0002161_abnormal_fertility/fecundity	2.35028678
9	MP0003646_muscle_fatigue	2.29284943
10	MP0005410_abnormal_fertilization	11.6400642
11	MP0000678_abnormal_parathyroid_gland	1.97979180
12	MP0003718_maternal_effect	1.89274962
13	MP0001485_abnormal_pinna_reflex	1.86126048
14	MP0005379_endocrine/exocrine_gland_phen	1.85144419
15	MP0003879_abnormal_hair_cell	1.83738527
16	MP0005423_abnormal_somatic_nervous	1.80934716
17	MP0003011_delayed_dark_adaptation	1.76516753
18	MP0001486_abnormal_startle_reflex	1.75410473
19	MP0002132_abnormal_respiratory_system	1.69271425
20	MP0005310_abnormal_salivary_gland	1.67079024
21	MP0004859_abnormal_synaptic_plasticity	1.66626945
22	MP0002210_abnormal_sex_determination	1.60645023
23	MP0004742_abnormal_vestibular_system	1.38023033
24	MP0001145_abnormal_male_reproductive	1.30432064
25	MP0002282_abnormal_trachea_morphology	1.29754778
26	MP0004510_myositis	1.25087624
27	MP0002249_abnormal_larynx_morphology	1.22323133
28	MP0000653_abnormal_sex_gland	1.21786975
29	MP0001963_abnormal_hearing_physiology	1.19938902
30	MP0005666_abnormal_adipose_tissue	1.15239717
31	MP0001765_abnormal_ion_homeostasis	1.13178951
32	MP0009115_abnormal_fat_cell	1.10539745
33	MP0000534_abnormal_ureter_morphology	1.08239702
34	MP0005248_abnormal_Harderian_gland	1.06165994
35	MP0009053_abnormal_anal_canal	1.03180798
36	MP0002822_catalepsy	1.00935809
37	MP0002234_abnormal_pharynx_morphology	0.98790439
38	MP0002127_abnormal_cardiovascular_syste	0.98073682
39	MP0004233_abnormal_muscle_weight	0.96368040
40	MP0000026_abnormal_inner_ear	0.92129993
41	MP0002735_abnormal_chemical_nociception	0.89040715
42	MP0002138_abnormal_hepatobiliary_system	0.88268683
43	MP0008569_lethality_at_weaning	0.87047783
44	MP0001984_abnormal_olfaction	0.85287372
45	MP0005375_adipose_tissue_phenotype	0.84889474
46	MP0002229_neurodegeneration	0.84610352
47	MP0000955_abnormal_spinal_cord	0.84541301
48	MP0005395_other_phenotype	0.84459229
49	MP0005167_abnormal_blood-brain_barrier	0.80300263
50	MP0005551_abnormal_eye_electrophysiolog	0.79869147
51	MP0004036_abnormal_muscle_relaxation	0.79327317
52	MP0005083_abnormal_biliary_tract	0.79293460
53	MP0002067_abnormal_sensory_capabilities	0.78109094
54	MP0005253_abnormal_eye_physiology	0.75672727
55	MP0009697_abnormal_copulation	0.75669037
56	MP0001968_abnormal_touch/_nociception	0.73776510
57	MP0004084_abnormal_cardiac_muscle	0.73328143
58	MP0005408_hypopigmentation	0.70347286
59	MP0004085_abnormal_heartbeat	0.69006394
60	MP0000681_abnormal_thyroid_gland	0.61973865
61	MP0002572_abnormal_emotion/affect_behav	0.61812845
62	MP0002557_abnormal_social/conspecific_i	0.61371681
63	MP0000003_abnormal_adipose_tissue	0.61116924
64	MP0003329_amyloid_beta_deposits	0.60526520
65	MP0002733_abnormal_thermal_nociception	0.60136935
66	MP0005623_abnormal_meninges_morphology	0.59804930
67	MP0008877_abnormal_DNA_methylation	0.56879447
68	MP0005636_abnormal_mineral_homeostasis	0.56404105
69	MP0005535_abnormal_body_temperature	0.55185049
70	MP0003137_abnormal_impulse_conducting	0.53079378
71	MP0010329_abnormal_lipoprotein_level	0.52183707
72	MP0001440_abnormal_grooming_behavior	0.50409782
73	MP0004484_altered_response_of	0.49433102
74	MP0000230_abnormal_systemic_arterial	0.48070044
75	MP0002269_muscular_atrophy	0.47630876
76	MP0001666_abnormal_nutrient_absorption	0.46642395
77	MP0001905_abnormal_dopamine_level	0.45372475
78	MP0003077_abnormal_cell_cycle	0.43297587
79	MP0005397_hematopoietic_system_phenotyp	0.42820286
80	MP0001545_abnormal_hematopoietic_system	0.42820286
81	MP0003631_nervous_system_phenotype	0.42432917
82	MP0008995_early_reproductive_senescence	0.42386588
83	MP0008961_abnormal_basal_metabolism	0.42330850
84	MP0002272_abnormal_nervous_system	0.42182202
85	MP0003172_abnormal_lysosome_physiology	0.42081383
86	MP0002734_abnormal_mechanical_nocicepti	0.42065611
87	MP0001879_abnormal_lymphatic_vessel	0.40974010
88	MP0003635_abnormal_synaptic_transmissio	0.39365087
89	MP0004782_abnormal_surfactant_physiolog	0.39220372
90	MP0000249_abnormal_blood_vessel	0.38113587
91	MP0009745_abnormal_behavioral_response	0.37830964
92	MP0001501_abnormal_sleep_pattern	0.37337376
93	MP0001970_abnormal_pain_threshold	0.37225475
94	MP0000049_abnormal_middle_ear	0.35852217
95	MP0005332_abnormal_amino_acid	0.35651420
96	MP0003633_abnormal_nervous_system	0.35382944
97	MP0001270_distended_abdomen	0.33999696
98	MP0005595_abnormal_vascular_smooth	0.33432091
99	MP0003091_abnormal_cell_migration	0.33382483
100	MP0000516_abnormal_urinary_system	0.33112974

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.16999652
2	Asymmetric septal hypertrophy (HP:0001670)	6.69289976
3	Tubulointerstitial nephritis (HP:0001970)	6.59871421
4	Chronic hepatic failure (HP:0100626)	6.02257694
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.99236480
6	Absent/shortened dynein arms (HP:0200106)	5.99236480
7	Resting tremor (HP:0002322)	4.75492980
8	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.72149016
9	Cone-rod dystrophy (HP:0000548)	4.65932355
10	Male infertility (HP:0003251)	4.60644369
11	Hyperkalemia (HP:0002153)	4.51764930
12	Nasal polyposis (HP:0100582)	4.49379110
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.43092545
14	Abnormal ciliary motility (HP:0012262)	4.40899411
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.32446178
16	Bony spicule pigmentary retinopathy (HP:0007737)	4.26348995
17	Attenuation of retinal blood vessels (HP:0007843)	4.17234234
18	Hypoalphalipoproteinemia (HP:0003233)	4.14633582
19	Abnormal respiratory epithelium morphology (HP:0012253)	4.02676380
20	Abnormal respiratory motile cilium morphology (HP:0005938)	4.02676380
21	Abnormality of macular pigmentation (HP:0008002)	4.02078683
22	Infertility (HP:0000789)	4.01544946
23	Menstrual irregularities (HP:0000858)	4.00520116
24	Progressive sensorineural hearing impairment (HP:0000408)	3.96194758
25	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.87283500
26	Abnormality of the nasal mucosa (HP:0000433)	3.70575358
27	Bell-shaped thorax (HP:0001591)	3.69767358
28	Hypoplasia of the thymus (HP:0000778)	3.68207360
29	Renovascular hypertension (HP:0100817)	3.58841877
30	Potter facies (HP:0002009)	3.53681372
31	Facial shape deformation (HP:0011334)	3.53681372
32	Amelogenesis imperfecta (HP:0000705)	3.42013435
33	Postural instability (HP:0002172)	3.33562449
34	Impulsivity (HP:0100710)	3.29002805
35	Truncal obesity (HP:0001956)	3.27974176
36	Abnormality of dental color (HP:0011073)	3.27817691
37	Enlarged epiphyses (HP:0010580)	3.18355317
38	Insulin-resistant diabetes mellitus (HP:0000831)	3.17910358
39	Progressive cerebellar ataxia (HP:0002073)	3.11718995
40	Stage 5 chronic kidney disease (HP:0003774)	3.05784767
41	Portal hypertension (HP:0001409)	3.03347615
42	Tubulointerstitial abnormality (HP:0001969)	3.00984651
43	Hypoplastic ischia (HP:0003175)	2.99683393
44	Abnormality of the hepatic vasculature (HP:0006707)	2.77930663
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.74539726
46	Abnormality of the ischium (HP:0003174)	2.73489586
47	Abnormal spermatogenesis (HP:0008669)	2.73226036
48	Progressive hearing impairment (HP:0001730)	2.64629152
49	Abnormality of the costochondral junction (HP:0000919)	2.60564070
50	Focal segmental glomerulosclerosis (HP:0000097)	2.59397175
51	Increased purine levels (HP:0004368)	2.58386961
52	Hyperuricemia (HP:0002149)	2.58386961
53	Rhinitis (HP:0012384)	2.57785559
54	Ventricular tachycardia (HP:0004756)	2.55853640
55	Intellectual disability, moderate (HP:0002342)	2.54428404
56	Subcapsular cataract (HP:0000523)	2.48220989
57	Abnormal urine output (HP:0012590)	2.41354746
58	Abnormality of potassium homeostasis (HP:0011042)	2.40974229
59	Nephronophthisis (HP:0000090)	2.40750660
60	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.35135256
61	Myokymia (HP:0002411)	2.32099347
62	Azoospermia (HP:0000027)	2.22673066
63	Chronic bronchitis (HP:0004469)	2.22585956
64	Abnormality of the aortic arch (HP:0012303)	2.19773781
65	Generalized aminoaciduria (HP:0002909)	2.19136177
66	Osteomalacia (HP:0002749)	2.19088962
67	Polydipsia (HP:0001959)	2.15777861
68	Abnormal drinking behavior (HP:0030082)	2.15777861
69	Unilateral renal agenesis (HP:0000122)	2.14719201
70	Glomerulosclerosis (HP:0000096)	2.11576315
71	Abnormality of the renal medulla (HP:0100957)	2.08412734
72	Hypolipoproteinemia (HP:0010981)	2.08346318
73	Abnormality of renal excretion (HP:0011036)	2.06076398
74	Flattened epiphyses (HP:0003071)	2.04065833
75	Recurrent pneumonia (HP:0006532)	1.98511929
76	Bradycardia (HP:0001662)	1.97844973
77	Hypophosphatemic rickets (HP:0004912)	1.96528773
78	Sandal gap (HP:0001852)	1.94824066
79	Congenital malformation of the right heart (HP:0011723)	1.93348000
80	Double outlet right ventricle (HP:0001719)	1.93348000
81	Insulin resistance (HP:0000855)	1.90967083
82	Hyponatremia (HP:0002902)	1.88791683
83	Widely patent fontanelles and sutures (HP:0004492)	1.86988350
84	Polyuria (HP:0000103)	1.86351941
85	Bronchiectasis (HP:0002110)	1.85047840
86	Renal dysplasia (HP:0000110)	1.82580598
87	Gingivitis (HP:0000230)	1.82036899
88	Obsessive-compulsive behavior (HP:0000722)	1.81108781
89	Upper limb muscle weakness (HP:0003484)	1.78352910
90	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.74381958
91	Abnormality of purine metabolism (HP:0004352)	1.74347749
92	Hypoalbuminemia (HP:0003073)	1.74097633
93	Abnormal albumin level (HP:0012116)	1.74097633
94	Abnormality of the parathyroid morphology (HP:0011766)	1.73534685
95	Acanthosis nigricans (HP:0000956)	1.73017948
96	Epiphyseal dysplasia (HP:0002656)	1.66256504
97	Neoplasm of the heart (HP:0100544)	1.64777273
98	Recurrent corneal erosions (HP:0000495)	1.64445753
99	Abnormality of femoral epiphyses (HP:0006499)	1.63706263
100	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.63706263

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	9.64124315
2	TESK1	4.73060740
3	INSRR	4.57935833
4	BRD4	4.42406316
5	PLK2	3.69744592
6	DDR2	3.67846857
7	PNCK	3.08614201
8	CAMK1G	2.60179219
9	STK38	2.56640442
10	PIK3CG	2.55331575
11	MAP4K2	2.41800285
12	PRKD3	2.13986183
13	STK38L	1.88671009
14	TYRO3	1.85153829
15	CDK12	1.74290884
16	MAPK15	1.66516063
17	PDK1	1.60385719
18	PDPK1	1.59982578
19	NEK6	1.58651427
20	WNK1	1.49969848
21	MST1R	1.41190003
22	DYRK1B	1.30524471
23	PTK2B	1.21857034
24	CAMK1D	1.08747589
25	KSR2	1.06937898
26	CDK7	0.99406933
27	AKT3	0.93847587
28	SIK2	0.88524828
29	MAP3K11	0.75344737
30	LATS2	0.74641452
31	TIE1	0.73368608
32	MAP3K9	0.71251374
33	PRKG2	0.70870188
34	MARK1	0.70195067
35	BRAF	0.65509496
36	UHMK1	0.60748922
37	CAMK1	0.60596677
38	PRKAA2	0.57567984
39	PRKG1	0.56412978
40	RPS6KA2	0.56238828
41	MAP3K2	0.52201647
42	NTRK3	0.51859188
43	CDK3	0.50328363
44	MAP2K2	0.48560115
45	SGK494	0.45443117
46	SGK223	0.45443117
47	MARK2	0.43486564
48	RPS6KA1	0.42320457
49	BRSK1	0.41463960
50	LATS1	0.40814641
51	MAP3K1	0.40227375
52	CAMK4	0.39193922
53	CDK2	0.39132629
54	MAPK1	0.38737981
55	GSK3B	0.38697596
56	ROCK1	0.37581081
57	CDK1	0.37304981
58	MTOR	0.36900932
59	RIPK4	0.36880118
60	JAK3	0.36323271
61	MAP3K8	0.33107152
62	ICK	0.29764847
63	MAPK8	0.29177090
64	SGK1	0.28830903
65	MAPK10	0.26719832
66	ARAF	0.25933329
67	PRKCZ	0.25771207
68	PRKCG	0.24743706
69	BLK	0.24576518
70	MAP3K7	0.22926374
71	RPS6KL1	0.22514014
72	RPS6KC1	0.22514014
73	MAPK11	0.22144936
74	PRKCB	0.20460412
75	MUSK	0.20163644
76	MAPK14	0.19581542
77	CHEK1	0.19329402
78	SGK2	0.19126740
79	MAP3K4	0.18431511
80	WNK4	0.18303676
81	CDK4	0.17112649
82	RPS6KA6	0.16264686
83	STK39	0.14749855
84	MET	0.14195503
85	MAP3K13	0.13040552
86	AKT1	0.13026603
87	SGK3	0.12984158
88	RIPK1	0.12349929
89	TESK2	0.11411964
90	PRKAA1	0.09630827
91	PKN1	0.08769268
92	PRKACB	0.08168534
93	MAP2K1	0.08013336
94	NEK2	0.07612837
95	OBSCN	0.06782894
96	MAPK9	0.06655377
97	PRKACA	0.05311738
98	RPS6KA3	0.04886288
99	CAMK2A	0.03911186
100	BRSK2	0.03854741

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.75199211
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.86889060
3	Olfactory transduction_Homo sapiens_hsa04740	3.72610549
4	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.72545105
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.19187606
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.99852748
7	Butanoate metabolism_Homo sapiens_hsa00650	1.84285978
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.79230596
9	RNA transport_Homo sapiens_hsa03013	1.74246317
10	Fatty acid degradation_Homo sapiens_hsa00071	1.70209950
11	Type II diabetes mellitus_Homo sapiens_hsa04930	1.67968350
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.67613407
13	Fatty acid metabolism_Homo sapiens_hsa01212	1.65213546
14	Taste transduction_Homo sapiens_hsa04742	1.61860051
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.55351400
16	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.37387458
17	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.28822674
18	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.23216386
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.21038589
20	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.20154334
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18470211
22	Endocytosis_Homo sapiens_hsa04144	1.09546999
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.09190042
24	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.07846511
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.07687730
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.05255690
27	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.03933707
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.02356380
29	VEGF signaling pathway_Homo sapiens_hsa04370	1.02231161
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.01806806
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.01039552
32	Viral myocarditis_Homo sapiens_hsa05416	0.99912684
33	Salivary secretion_Homo sapiens_hsa04970	0.99525736
34	Calcium signaling pathway_Homo sapiens_hsa04020	0.96196043
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.93511558
36	cAMP signaling pathway_Homo sapiens_hsa04024	0.93494267
37	Morphine addiction_Homo sapiens_hsa05032	0.92261535
38	ABC transporters_Homo sapiens_hsa02010	0.90554806
39	Allograft rejection_Homo sapiens_hsa05330	0.90238377
40	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89918353
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88571984
42	Influenza A_Homo sapiens_hsa05164	0.87019804
43	Glutamatergic synapse_Homo sapiens_hsa04724	0.87012068
44	Long-term potentiation_Homo sapiens_hsa04720	0.85119472
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83591472
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82064663
47	Nicotine addiction_Homo sapiens_hsa05033	0.81276524
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.78935116
49	Oocyte meiosis_Homo sapiens_hsa04114	0.77169130
50	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76865509
51	Phototransduction_Homo sapiens_hsa04744	0.76585590
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.76553996
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75359504
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.75257209
55	Circadian entrainment_Homo sapiens_hsa04713	0.75050742
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70792170
57	Renin secretion_Homo sapiens_hsa04924	0.69883175
58	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.68719115
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.66932353
60	Gastric acid secretion_Homo sapiens_hsa04971	0.66568206
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65365925
62	Renin-angiotensin system_Homo sapiens_hsa04614	0.62579839
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62425668
64	Acute myeloid leukemia_Homo sapiens_hsa05221	0.61953823
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.60449365
66	Bile secretion_Homo sapiens_hsa04976	0.59579742
67	Pancreatic secretion_Homo sapiens_hsa04972	0.58239669
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.55234161
69	MAPK signaling pathway_Homo sapiens_hsa04010	0.54043667
70	Insulin secretion_Homo sapiens_hsa04911	0.53892457
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.52040232
72	Cholinergic synapse_Homo sapiens_hsa04725	0.51863752
73	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.51189165
74	Serotonergic synapse_Homo sapiens_hsa04726	0.50789733
75	GABAergic synapse_Homo sapiens_hsa04727	0.48223714
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.46953498
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46688165
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45559171
79	Amphetamine addiction_Homo sapiens_hsa05031	0.45358909
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42779999
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42724943
82	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.41621602
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39599489
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39144700
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.37595675
86	Prolactin signaling pathway_Homo sapiens_hsa04917	0.35706063
87	Tight junction_Homo sapiens_hsa04530	0.34969669
88	Choline metabolism in cancer_Homo sapiens_hsa05231	0.34314801
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33666678
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.33538641
91	Carbon metabolism_Homo sapiens_hsa01200	0.33495885
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33457516
93	Adherens junction_Homo sapiens_hsa04520	0.33428677
94	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.31661817
95	Retinol metabolism_Homo sapiens_hsa00830	0.30475034
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29914384
97	Non-small cell lung cancer_Homo sapiens_hsa05223	0.29774585
98	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28761388
99	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26714372
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.24930975

C21ORF140

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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