C21ORF33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a potential mitochondrial protein that is a member of the DJ-1/PfpI gene family. This protein is overexpressed in fetal Down syndrome brain. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxidative phosphorylation (GO:0006119)5.49487427
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.41152381
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.24031604
4ATP synthesis coupled proton transport (GO:0015986)5.24031604
5ribosomal small subunit biogenesis (GO:0042274)5.17752002
6viral transcription (GO:0019083)5.01782103
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.72752273
8translational termination (GO:0006415)4.66049123
9translational elongation (GO:0006414)4.36449059
10respiratory electron transport chain (GO:0022904)4.27118888
11protein complex biogenesis (GO:0070271)4.27040188
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.18397272
13electron transport chain (GO:0022900)4.16289618
14peptidyl-arginine omega-N-methylation (GO:0035247)4.13401472
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10376152
16mitochondrial respiratory chain complex assembly (GO:0033108)4.09194067
17protein targeting to mitochondrion (GO:0006626)4.05794633
18proline biosynthetic process (GO:0006561)4.04810205
19metallo-sulfur cluster assembly (GO:0031163)4.04639813
20iron-sulfur cluster assembly (GO:0016226)4.04639813
21regulation of mitochondrial translation (GO:0070129)4.03256683
22protein targeting to ER (GO:0045047)4.02923200
23maturation of SSU-rRNA (GO:0030490)4.00758321
24cotranslational protein targeting to membrane (GO:0006613)3.97476588
25branched-chain amino acid catabolic process (GO:0009083)3.97469574
26establishment of protein localization to mitochondrion (GO:0072655)3.84505584
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.84492221
28protein localization to endoplasmic reticulum (GO:0070972)3.84434597
29muscle cell fate commitment (GO:0042693)3.83242121
30ribosomal small subunit assembly (GO:0000028)3.83173435
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80493421
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.80493421
33NADH dehydrogenase complex assembly (GO:0010257)3.80493421
34chaperone-mediated protein transport (GO:0072321)3.73733064
35peptidyl-histidine modification (GO:0018202)3.72860988
36GTP biosynthetic process (GO:0006183)3.68093042
37viral life cycle (GO:0019058)3.68084217
38purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63279730
39histone arginine methylation (GO:0034969)3.62286416
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62031561
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.61426503
42ribosomal large subunit biogenesis (GO:0042273)3.60013513
43translation (GO:0006412)3.59490299
44ATP biosynthetic process (GO:0006754)3.59321280
45translational initiation (GO:0006413)3.57765305
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57258425
47guanosine-containing compound biosynthetic process (GO:1901070)3.57131725
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56968642
49UTP biosynthetic process (GO:0006228)3.55230990
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.52184211
51cellular protein complex disassembly (GO:0043624)3.47162701
52branched-chain amino acid metabolic process (GO:0009081)3.46220410
53protein localization to mitochondrion (GO:0070585)3.44068097
54ribonucleoside triphosphate biosynthetic process (GO:0009201)3.43676391
55heart contraction (GO:0060047)3.40882247
56heart process (GO:0003015)3.40882247
57peptidyl-arginine N-methylation (GO:0035246)3.39243505
58peptidyl-arginine methylation (GO:0018216)3.39243505
59cellular component biogenesis (GO:0044085)3.38705356
60NADH metabolic process (GO:0006734)3.35258478
61formation of translation preinitiation complex (GO:0001731)3.32761449
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.27839421
63termination of RNA polymerase III transcription (GO:0006386)3.27839421
64pseudouridine synthesis (GO:0001522)3.27251880
65ribonucleoprotein complex biogenesis (GO:0022613)3.25719667
66UTP metabolic process (GO:0046051)3.24785966
67proline metabolic process (GO:0006560)3.24316087
68mitochondrial transport (GO:0006839)3.20274933
69purine nucleoside monophosphate biosynthetic process (GO:0009127)3.18472021
70purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.18472021
71CTP metabolic process (GO:0046036)3.17104875
72CTP biosynthetic process (GO:0006241)3.17104875
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13139251
74pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.10648291
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.10444062
76nucleoside triphosphate biosynthetic process (GO:0009142)3.09691226
77pentose metabolic process (GO:0019321)3.06644412
78transcription from mitochondrial promoter (GO:0006390)3.06213531
79cytochrome complex assembly (GO:0017004)3.05324044
80protein complex disassembly (GO:0043241)3.04976466
81GDP-mannose metabolic process (GO:0019673)3.04229170
82telomere maintenance via semi-conservative replication (GO:0032201)3.01149279
83spliceosomal snRNP assembly (GO:0000387)2.98983946
84pyrimidine nucleotide catabolic process (GO:0006244)2.98644665
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97686175
86negative regulation of ligase activity (GO:0051352)2.97686175
87L-serine metabolic process (GO:0006563)2.97677354
88cullin deneddylation (GO:0010388)2.96709638
89valine metabolic process (GO:0006573)2.95791372
90base-excision repair, AP site formation (GO:0006285)2.95228563
91activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.94462478
92pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92676213
93regulation of translational fidelity (GO:0006450)2.91242434
94ribonucleoside monophosphate biosynthetic process (GO:0009156)2.90649355
95pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.90561573
96creatine metabolic process (GO:0006600)2.90505529
97respiratory chain complex IV assembly (GO:0008535)2.89806614
98macromolecular complex disassembly (GO:0032984)2.89456885
99DNA strand elongation involved in DNA replication (GO:0006271)2.88459461
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88273211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.64261330
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63470303
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54842639
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.19608501
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08795132
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00950541
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90231676
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.90228187
9THAP11_20581084_ChIP-Seq_MESCs_Mouse2.84049788
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.77875990
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68813330
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65508188
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64799042
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.64644936
15XRN2_22483619_ChIP-Seq_HELA_Human2.56070452
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55026022
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53209509
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24800715
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23986642
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.16900953
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06409429
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05055390
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98013619
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.97732206
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.89769501
26* GABP_19822575_ChIP-Seq_HepG2_Human1.89760526
27E2F7_22180533_ChIP-Seq_HELA_Human1.89667116
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88437765
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87628254
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.84630194
31VDR_23849224_ChIP-Seq_CD4+_Human1.80924354
32FOXP3_21729870_ChIP-Seq_TREG_Human1.79739562
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79568285
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78201253
35DCP1A_22483619_ChIP-Seq_HELA_Human1.77880915
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72508633
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.71299104
38VDR_21846776_ChIP-Seq_THP-1_Human1.70258119
39TTF2_22483619_ChIP-Seq_HELA_Human1.67646607
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65934507
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64701487
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.64148864
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60315480
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55624524
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52506463
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52241815
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51825898
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50967501
49CIITA_25753668_ChIP-Seq_RAJI_Human1.48111366
50* LXR_22292898_ChIP-Seq_THP-1_Human1.44041200
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43255301
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40476110
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38931414
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.38467524
55* MYC_22102868_ChIP-Seq_BL_Human1.36171571
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33693232
57KDM5A_27292631_Chip-Seq_BREAST_Human1.32670483
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31106033
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30798625
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30570574
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29821383
62CTCF_26484167_Chip-Seq_Bcells_Mouse1.29740587
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28783812
64FOXP1_21924763_ChIP-Seq_HESCs_Human1.28147181
65P68_20966046_ChIP-Seq_HELA_Human1.27043229
66* BCL6_27268052_Chip-Seq_Bcells_Human1.26893796
67ZNF263_19887448_ChIP-Seq_K562_Human1.24252515
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22754746
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18982783
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15084799
71* YY1_22570637_ChIP-Seq_MALME-3M_Human1.14987873
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13983200
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11836058
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11770619
75MAF_26560356_Chip-Seq_TH2_Human1.10299510
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.10048812
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09887527
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09453388
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08316191
80BCOR_27268052_Chip-Seq_Bcells_Human1.06611774
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06163269
82RARA_24833708_ChIP-Seq_LIVER_Mouse1.05899673
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05868260
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04366933
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02945206
86E2F1_20622854_ChIP-Seq_HELA_Human1.02771866
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02602480
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02396884
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02089624
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98965133
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98875967
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98166960
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97134271
94BP1_19119308_ChIP-ChIP_Hs578T_Human0.96739743
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96359945
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95471285
97CTCF_21964334_Chip-Seq_Bcells_Human0.94774771
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94743975
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93513733
100SA1_27219007_Chip-Seq_Bcells_Human0.92106770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006036_abnormal_mitochondrial_physio3.82180479
2MP0003806_abnormal_nucleotide_metabolis3.50769307
3MP0002837_dystrophic_cardiac_calcinosis3.13935032
4MP0001661_extended_life_span2.77609028
5MP0005451_abnormal_body_composition2.62365605
6MP0009333_abnormal_splenocyte_physiolog2.57344791
7MP0003693_abnormal_embryo_hatching2.56879079
8MP0008058_abnormal_DNA_repair2.49279934
9MP0002234_abnormal_pharynx_morphology2.31115921
10MP0006035_abnormal_mitochondrial_morpho2.30662758
11MP0003786_premature_aging2.29563989
12MP0004957_abnormal_blastocyst_morpholog2.19152531
13MP0002163_abnormal_gland_morphology2.10643060
14MP0010030_abnormal_orbit_morphology2.06788491
15MP0000749_muscle_degeneration2.06097614
16MP0003186_abnormal_redox_activity2.05168533
17MP0004036_abnormal_muscle_relaxation2.00367966
18MP0003111_abnormal_nucleus_morphology1.98858526
19MP0005330_cardiomyopathy1.96395695
20MP0000678_abnormal_parathyroid_gland1.95234027
21MP0010094_abnormal_chromosome_stability1.91706320
22MP0005332_abnormal_amino_acid1.87322452
23MP0001764_abnormal_homeostasis1.86722312
24MP0004145_abnormal_muscle_electrophysio1.82674863
25MP0005670_abnormal_white_adipose1.79886447
26MP0004084_abnormal_cardiac_muscle1.77229918
27MP0002822_catalepsy1.72186053
28MP0001346_abnormal_lacrimal_gland1.70213499
29MP0002249_abnormal_larynx_morphology1.68432852
30MP0008007_abnormal_cellular_replicative1.68095642
31MP0008932_abnormal_embryonic_tissue1.66273472
32MP0008260_abnormal_autophagy1.60219779
33MP0002132_abnormal_respiratory_system1.59740035
34MP0005671_abnormal_response_to1.57299927
35MP0000372_irregular_coat_pigmentation1.53356378
36MP0008875_abnormal_xenobiotic_pharmacok1.51879311
37MP0000685_abnormal_immune_system1.50532672
38MP0003077_abnormal_cell_cycle1.49139522
39MP0003646_muscle_fatigue1.48012987
40MP0002139_abnormal_hepatobiliary_system1.46893004
41MP0000751_myopathy1.43508944
42MP0000747_muscle_weakness1.41201692
43MP0003436_decreased_susceptibility_to1.40317869
44MP0002160_abnormal_reproductive_system1.39944025
45MP0000681_abnormal_thyroid_gland1.28720175
46MP0003137_abnormal_impulse_conducting1.28286208
47MP0008995_early_reproductive_senescence1.24734379
48MP0000759_abnormal_skeletal_muscle1.21557708
49MP0005058_abnormal_lysosome_morphology1.19525966
50MP0003315_abnormal_perineum_morphology1.15370497
51MP0001790_abnormal_immune_system1.14318654
52MP0005387_immune_system_phenotype1.14318654
53MP0004215_abnormal_myocardial_fiber1.10702413
54MP0000358_abnormal_cell_content/1.08486298
55MP0005365_abnormal_bile_salt1.08111362
56MP0000313_abnormal_cell_death1.07155121
57MP0004087_abnormal_muscle_fiber1.06143564
58MP0001835_abnormal_antigen_presentation1.05753055
59MP0002148_abnormal_hypersensitivity_rea1.02140909
60MP0009379_abnormal_foot_pigmentation1.00322961
61MP0003763_abnormal_thymus_physiology1.00184373
62MP0000750_abnormal_muscle_regeneration0.98007632
63MP0002723_abnormal_immune_serum0.94493038
64MP0004147_increased_porphyrin_level0.92285107
65MP0001800_abnormal_humoral_immune0.91821334
66MP0000703_abnormal_thymus_morphology0.89095041
67MP0009785_altered_susceptibility_to0.87595007
68MP0002876_abnormal_thyroid_physiology0.87166520
69MP0004185_abnormal_adipocyte_glucose0.85920946
70MP0002277_abnormal_respiratory_mucosa0.85244153
71MP0000733_abnormal_muscle_development0.85133934
72MP0002269_muscular_atrophy0.84267202
73MP0002106_abnormal_muscle_physiology0.83281253
74MP0005379_endocrine/exocrine_gland_phen0.82340241
75MP0005187_abnormal_penis_morphology0.81830537
76MP0000689_abnormal_spleen_morphology0.81646363
77MP0001919_abnormal_reproductive_system0.81003428
78MP0005000_abnormal_immune_tolerance0.79507712
79MP0001905_abnormal_dopamine_level0.78328921
80MP0002398_abnormal_bone_marrow0.78207131
81MP0002722_abnormal_immune_system0.78190404
82MP0000343_altered_response_to0.75038709
83MP0003011_delayed_dark_adaptation0.73945441
84MP0002933_joint_inflammation0.72989086
85MP0002429_abnormal_blood_cell0.72914381
86MP0009643_abnormal_urine_homeostasis0.72459826
87MP0005360_urolithiasis0.72155386
88MP0008789_abnormal_olfactory_epithelium0.71924252
89MP0005319_abnormal_enzyme/_coenzyme0.70779864
90MP0001544_abnormal_cardiovascular_syste0.70077387
91MP0005385_cardiovascular_system_phenoty0.70077387
92MP0005083_abnormal_biliary_tract0.69468941
93MP0002420_abnormal_adaptive_immunity0.69189671
94MP0005266_abnormal_metabolism0.69038829
95MP0005389_reproductive_system_phenotype0.68649113
96MP0001819_abnormal_immune_cell0.68423089
97MP0001730_embryonic_growth_arrest0.68342870
98MP0002452_abnormal_antigen_presenting0.68018708
99MP0005646_abnormal_pituitary_gland0.67325847
100MP0008775_abnormal_heart_ventricle0.66854721

Predicted human phenotypes

RankGene SetZ-score
1Increased intramyocellular lipid droplets (HP:0012240)5.01743460
2Abnormal mitochondria in muscle tissue (HP:0008316)4.88834634
3Increased muscle lipid content (HP:0009058)4.75189013
4Acute necrotizing encephalopathy (HP:0006965)4.54429335
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.37446875
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.37446875
7Acute encephalopathy (HP:0006846)4.30149696
8Mitochondrial inheritance (HP:0001427)4.28441914
9Increased CSF lactate (HP:0002490)3.93496627
10Renal Fanconi syndrome (HP:0001994)3.91872603
11Hepatic necrosis (HP:0002605)3.91181640
12Increased hepatocellular lipid droplets (HP:0006565)3.85909508
13Lipid accumulation in hepatocytes (HP:0006561)3.85160363
14Exercise intolerance (HP:0003546)3.75495265
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.66779076
16Hepatocellular necrosis (HP:0001404)3.60550475
17Progressive macrocephaly (HP:0004481)3.57491588
18Lactic acidosis (HP:0003128)3.55904979
193-Methylglutaconic aciduria (HP:0003535)3.37691229
20Increased serum lactate (HP:0002151)3.35054814
21Cerebral edema (HP:0002181)3.34643649
22Exercise-induced myalgia (HP:0003738)3.30214695
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.21319475
24Generalized aminoaciduria (HP:0002909)3.18237464
25Ragged-red muscle fibers (HP:0003200)3.06321940
26Abnormal number of erythroid precursors (HP:0012131)3.05064084
27Abnormality of cells of the erythroid lineage (HP:0012130)3.02154838
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91406239
29Abnormality of glycolysis (HP:0004366)2.86179779
30Muscle fiber atrophy (HP:0100295)2.80757695
31Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76890093
32Dicarboxylic aciduria (HP:0003215)2.76890093
33Respiratory difficulties (HP:0002880)2.76406582
34Abnormal gallbladder physiology (HP:0012438)2.66917303
35Cholecystitis (HP:0001082)2.66917303
36Increased serum pyruvate (HP:0003542)2.64804042
37Macrocytic anemia (HP:0001972)2.62999955
38Type 2 muscle fiber atrophy (HP:0003554)2.60035267
39Testicular atrophy (HP:0000029)2.59725378
40Double outlet right ventricle (HP:0001719)2.58240152
41Congenital malformation of the right heart (HP:0011723)2.58240152
42Abnormality of fatty-acid metabolism (HP:0004359)2.57898577
43Progressive muscle weakness (HP:0003323)2.56594053
44Respiratory failure (HP:0002878)2.56512989
45Reticulocytopenia (HP:0001896)2.53733875
46Abnormality of T cell physiology (HP:0011840)2.51699661
47Myoglobinuria (HP:0002913)2.49846954
48Rhabdomyolysis (HP:0003201)2.49212611
49Abnormal pupillary function (HP:0007686)2.45350359
50Hypertensive crisis (HP:0100735)2.44914300
51Type I transferrin isoform profile (HP:0003642)2.43084059
52Cholelithiasis (HP:0001081)2.38395775
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37956437
54Exertional dyspnea (HP:0002875)2.36538409
55Muscle fiber inclusion bodies (HP:0100299)2.35378927
56Nemaline bodies (HP:0003798)2.31772630
57Microretrognathia (HP:0000308)2.30278631
58Hyperthyroidism (HP:0000836)2.29835733
59Lethargy (HP:0001254)2.29148899
60Glycosuria (HP:0003076)2.28321661
61Abnormality of urine glucose concentration (HP:0011016)2.28321661
62Hypoplastic heart (HP:0001961)2.27838284
63Truncus arteriosus (HP:0001660)2.26196326
64Redundant skin (HP:0001582)2.23815928
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23423559
66Nausea (HP:0002018)2.22513313
67Hyperammonemia (HP:0001987)2.19297178
68Hypoplastic left heart (HP:0004383)2.15267839
69Myopathic facies (HP:0002058)2.12286579
70Microvesicular hepatic steatosis (HP:0001414)2.11434853
71Abnormal gallbladder morphology (HP:0012437)2.08396038
72Cerebral hypomyelination (HP:0006808)2.01503640
73Muscle stiffness (HP:0003552)2.01311130
74Emotional lability (HP:0000712)1.99089225
75Bulbar palsy (HP:0001283)1.98314213
76Esophageal neoplasm (HP:0100751)1.96973934
77Neoplasm of head and neck (HP:0012288)1.96973934
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93748660
79Abnormal protein N-linked glycosylation (HP:0012347)1.93748660
80Abnormal protein glycosylation (HP:0012346)1.93748660
81Abnormal glycosylation (HP:0012345)1.93748660
82Pallor (HP:0000980)1.92130628
83Reduced antithrombin III activity (HP:0001976)1.92011447
84Amniotic constriction ring (HP:0009775)1.89697912
85Abnormality of placental membranes (HP:0011409)1.89697912
86Metabolic acidosis (HP:0001942)1.88293403
87Ketosis (HP:0001946)1.87460284
88Methylmalonic aciduria (HP:0012120)1.84540540
89Abnormality of renal resorption (HP:0011038)1.84243288
90Seborrheic dermatitis (HP:0001051)1.81809395
91Gastrointestinal stroma tumor (HP:0100723)1.81551001
92Opisthotonus (HP:0002179)1.81293125
93Leukodystrophy (HP:0002415)1.80384890
94Pancytopenia (HP:0001876)1.79881154
95Cerebral palsy (HP:0100021)1.78521580
96Hypoglycemic coma (HP:0001325)1.77330410
97Delusions (HP:0000746)1.77100051
98Exercise-induced muscle cramps (HP:0003710)1.76993417
99Agammaglobulinemia (HP:0004432)1.75903449
100Abnormality of the anterior horn cell (HP:0006802)1.75628815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.27832774
2NME24.77926862
3STK163.90408237
4BCKDK3.70942982
5BUB13.70351217
6SMG13.40897216
7IRAK32.38316039
8TLK12.35507810
9VRK12.25952204
10TRIB32.22852638
11NEK12.18864437
12PRKD32.18364219
13ZAK1.88046855
14PDK21.81590464
15TAF11.79740770
16KDR1.63853525
17DAPK31.57011694
18MUSK1.56959995
19DAPK11.55559097
20EIF2AK11.46098746
21EEF2K1.37251310
22MAP2K21.36331318
23NME11.33793235
24ARAF1.33562174
25PIM21.31089000
26TESK21.30669735
27MAPKAPK51.18116026
28CSNK1G31.16263247
29ILK1.14231253
30GRK51.10700163
31GRK61.08278020
32TAOK31.07078377
33CDK81.05689662
34TAOK21.04836563
35MAP2K31.03772465
36RPS6KA51.01575072
37PHKG11.00946754
38PHKG21.00946754
39MAPKAPK30.99665618
40TBK10.98875976
41AURKA0.98599015
42OBSCN0.98014778
43CCNB10.94334210
44CDC70.93938280
45TNK20.90165919
46RIPK40.89788618
47CSNK1A1L0.86444035
48MAPK110.84322078
49ABL20.82494543
50IKBKB0.82123689
51MAPK120.79286110
52LRRK20.76798059
53PRPF4B0.75138551
54CSNK1G20.74293955
55CDK70.73685533
56MAP3K110.73543795
57CHEK20.72262277
58STK40.70664462
59NUAK10.69693395
60IRAK40.66338543
61PLK40.66206652
62NEK90.63741283
63TYK20.63300393
64CDK40.62842599
65IRAK20.62741645
66PRKCI0.61282399
67BRAF0.60846193
68ATR0.59869678
69CSNK1G10.57506491
70AKT20.56889841
71TTK0.53613539
72TXK0.51121859
73CSNK2A20.49568386
74CDC42BPA0.49297437
75CAMK1D0.48908501
76SRPK10.47924068
77CSNK2A10.46610990
78PLK30.46292130
79MAP4K10.44933011
80AURKB0.44400685
81BRSK10.41794870
82PAK10.39950713
83ICK0.38591305
84CHEK10.38473714
85EIF2AK20.37775598
86LIMK10.37337009
87FES0.36730731
88EIF2AK30.34421772
89MAPK40.33625359
90MAP3K100.32901173
91CDK90.32581392
92PIM10.31682498
93PLK10.29798653
94MAP3K80.29781714
95RPS6KL10.29657030
96RPS6KC10.29657030
97MAP2K10.27140039
98ADRBK20.26087049
99RPS6KA10.25698167
100PASK0.23581447

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38458214
2Sulfur relay system_Homo sapiens_hsa041224.06787457
3Oxidative phosphorylation_Homo sapiens_hsa001903.38109999
4Proteasome_Homo sapiens_hsa030503.14526179
5Parkinsons disease_Homo sapiens_hsa050123.09933309
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73710076
7DNA replication_Homo sapiens_hsa030302.73380837
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33191746
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32668157
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29819629
11Alzheimers disease_Homo sapiens_hsa050102.11101714
12Base excision repair_Homo sapiens_hsa034102.08789807
13RNA polymerase_Homo sapiens_hsa030202.07429539
14Mismatch repair_Homo sapiens_hsa034302.05717682
15Huntingtons disease_Homo sapiens_hsa050162.00284668
16Biosynthesis of amino acids_Homo sapiens_hsa012301.93046273
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91187395
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86655050
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.84339001
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77477980
21One carbon pool by folate_Homo sapiens_hsa006701.73474726
22Pyrimidine metabolism_Homo sapiens_hsa002401.67389414
23Sulfur metabolism_Homo sapiens_hsa009201.62669926
24Carbon metabolism_Homo sapiens_hsa012001.60218151
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.58215212
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55900867
27Homologous recombination_Homo sapiens_hsa034401.48383926
28Pyruvate metabolism_Homo sapiens_hsa006201.48018243
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47728773
30Spliceosome_Homo sapiens_hsa030401.46757076
31Cardiac muscle contraction_Homo sapiens_hsa042601.44868762
32Arginine and proline metabolism_Homo sapiens_hsa003301.36001054
33Propanoate metabolism_Homo sapiens_hsa006401.22438412
34Systemic lupus erythematosus_Homo sapiens_hsa053221.21763465
35Nucleotide excision repair_Homo sapiens_hsa034201.20020924
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18222858
37Fatty acid elongation_Homo sapiens_hsa000621.16303948
38Primary immunodeficiency_Homo sapiens_hsa053401.11606965
39Purine metabolism_Homo sapiens_hsa002301.10459186
40Caffeine metabolism_Homo sapiens_hsa002321.07893448
41Pentose phosphate pathway_Homo sapiens_hsa000301.07592133
42Fructose and mannose metabolism_Homo sapiens_hsa000511.06163205
43Vitamin B6 metabolism_Homo sapiens_hsa007501.05094969
44Phenylalanine metabolism_Homo sapiens_hsa003601.00863474
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99164603
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.97388965
47Autoimmune thyroid disease_Homo sapiens_hsa053200.92931429
48Fanconi anemia pathway_Homo sapiens_hsa034600.91124758
49Allograft rejection_Homo sapiens_hsa053300.89666985
50Peroxisome_Homo sapiens_hsa041460.87231518
51Galactose metabolism_Homo sapiens_hsa000520.84589269
52Asthma_Homo sapiens_hsa053100.82607029
53Metabolic pathways_Homo sapiens_hsa011000.79931211
54Glutathione metabolism_Homo sapiens_hsa004800.78289980
55Fatty acid degradation_Homo sapiens_hsa000710.77932419
56Non-homologous end-joining_Homo sapiens_hsa034500.75629234
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75345784
58Arginine biosynthesis_Homo sapiens_hsa002200.74349549
59RNA transport_Homo sapiens_hsa030130.73630423
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68463772
61Tyrosine metabolism_Homo sapiens_hsa003500.67255377
62Graft-versus-host disease_Homo sapiens_hsa053320.66230858
63Fatty acid metabolism_Homo sapiens_hsa012120.65990332
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64775273
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.64134277
66Other glycan degradation_Homo sapiens_hsa005110.62267878
67RNA degradation_Homo sapiens_hsa030180.60419462
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57245303
69Folate biosynthesis_Homo sapiens_hsa007900.55135102
70Tryptophan metabolism_Homo sapiens_hsa003800.54883090
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53473349
72Type I diabetes mellitus_Homo sapiens_hsa049400.53224524
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51540053
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.49911119
75Selenocompound metabolism_Homo sapiens_hsa004500.49885213
76Collecting duct acid secretion_Homo sapiens_hsa049660.47382290
77Epstein-Barr virus infection_Homo sapiens_hsa051690.45178487
78Antigen processing and presentation_Homo sapiens_hsa046120.42608531
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39040120
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38810643
81Rheumatoid arthritis_Homo sapiens_hsa053230.36878320
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35015364
83Herpes simplex infection_Homo sapiens_hsa051680.34625481
84Viral myocarditis_Homo sapiens_hsa054160.34492168
85beta-Alanine metabolism_Homo sapiens_hsa004100.34193240
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32618020
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31148898
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31069117
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30835298
90Butanoate metabolism_Homo sapiens_hsa006500.30331426
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28174562
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27160691
93Chemical carcinogenesis_Homo sapiens_hsa052040.25778589
94p53 signaling pathway_Homo sapiens_hsa041150.24559354
95Alcoholism_Homo sapiens_hsa050340.21609431
96Basal transcription factors_Homo sapiens_hsa030220.20612307
97Cell cycle_Homo sapiens_hsa041100.16643109
98Protein export_Homo sapiens_hsa030600.16605917
99N-Glycan biosynthesis_Homo sapiens_hsa005100.15426652
100Arachidonic acid metabolism_Homo sapiens_hsa005900.12808891

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