ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	6.96135778
2	cilium movement (GO:0003341)	6.35149221
3	auditory behavior (GO:0031223)	5.59530588
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.56460082
5	presynaptic membrane assembly (GO:0097105)	5.56071792
6	postsynaptic membrane organization (GO:0001941)	5.32140812
7	axonemal dynein complex assembly (GO:0070286)	5.14678606
8	neuron cell-cell adhesion (GO:0007158)	4.89351184
9	mechanosensory behavior (GO:0007638)	4.87434832
10	intraciliary transport (GO:0042073)	4.79276945
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.76844652
12	presynaptic membrane organization (GO:0097090)	4.63609844
13	retinal ganglion cell axon guidance (GO:0031290)	4.41852983
14	cilium morphogenesis (GO:0060271)	4.25712594
15	axoneme assembly (GO:0035082)	4.18951217
16	nonmotile primary cilium assembly (GO:0035058)	4.17099147
17	response to auditory stimulus (GO:0010996)	4.13481932
18	pyrimidine nucleobase catabolic process (GO:0006208)	4.04208852
19	platelet dense granule organization (GO:0060155)	3.95557427
20	cilium organization (GO:0044782)	3.91324708
21	cilium assembly (GO:0042384)	3.86737132
22	C4-dicarboxylate transport (GO:0015740)	3.76851868
23	regulation of cilium movement (GO:0003352)	3.70160286
24	positive regulation of mitochondrial fission (GO:0090141)	3.56997195
25	negative regulation of axon guidance (GO:1902668)	3.54127460
26	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.50662093
27	vascular smooth muscle contraction (GO:0014829)	3.46498115
28	vitamin A metabolic process (GO:0006776)	3.40191316
29	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.35792594
30	axon extension involved in axon guidance (GO:0048846)	3.35792594
31	neurotransmitter uptake (GO:0001504)	3.33566198
32	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.33129083
33	ventricular system development (GO:0021591)	3.32422402
34	protein polyglutamylation (GO:0018095)	3.29224739
35	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.27730459
36	artery smooth muscle contraction (GO:0014824)	3.25196312
37	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.23273164
38	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.23273164
39	carnitine metabolic process (GO:0009437)	3.19860197
40	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.14918204
41	cullin deneddylation (GO:0010388)	3.09761677
42	nucleobase catabolic process (GO:0046113)	3.09492380
43	smoothened signaling pathway (GO:0007224)	3.07117722
44	vocalization behavior (GO:0071625)	3.06839583
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.05261757
46	negative regulation of axon extension (GO:0030517)	3.04512183
47	protein localization to cilium (GO:0061512)	3.01038953
48	cellular component assembly involved in morphogenesis (GO:0010927)	3.00898275
49	neurotransmitter-gated ion channel clustering (GO:0072578)	2.96639439
50	behavioral response to nicotine (GO:0035095)	2.90903677
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88364236
52	sequestering of actin monomers (GO:0042989)	2.85525270
53	motile cilium assembly (GO:0044458)	2.84899424
54	positive regulation of gastrulation (GO:2000543)	2.82619383
55	axonal fasciculation (GO:0007413)	2.80122468
56	head development (GO:0060322)	2.79895786
57	cholesterol biosynthetic process (GO:0006695)	2.77479042
58	regulation of axon guidance (GO:1902667)	2.74961568
59	cellular response to leptin stimulus (GO:0044320)	2.74943744
60	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.73689332
61	neuron fate determination (GO:0048664)	2.72963481
62	startle response (GO:0001964)	2.71283994
63	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.71272434
64	amino-acid betaine metabolic process (GO:0006577)	2.68088902
65	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.67717313
66	tonic smooth muscle contraction (GO:0014820)	2.65996366
67	limb development (GO:0060173)	2.65582934
68	appendage development (GO:0048736)	2.65582934
69	synapse assembly (GO:0007416)	2.65184193
70	olfactory bulb development (GO:0021772)	2.63710877
71	ubiquinone metabolic process (GO:0006743)	2.63458392
72	response to pheromone (GO:0019236)	2.60383449
73	cysteine metabolic process (GO:0006534)	2.60083924
74	protein deneddylation (GO:0000338)	2.59570429
75	short-term memory (GO:0007614)	2.59378077
76	glycosphingolipid biosynthetic process (GO:0006688)	2.57840426
77	telencephalon development (GO:0021537)	2.56436451
78	regulation of feeding behavior (GO:0060259)	2.56379022
79	nucleoside diphosphate phosphorylation (GO:0006165)	2.55452533
80	protein localization to synapse (GO:0035418)	2.55301400
81	regulation of collateral sprouting (GO:0048670)	2.53990215
82	regulation of cardiac muscle cell contraction (GO:0086004)	2.53865278
83	sterol biosynthetic process (GO:0016126)	2.52576755
84	positive regulation of synapse assembly (GO:0051965)	2.48625037
85	response to nitrosative stress (GO:0051409)	2.47855799
86	regulation of dopamine secretion (GO:0014059)	2.47545408
87	neuron recognition (GO:0008038)	2.47405651
88	regulation of development, heterochronic (GO:0040034)	2.47276632
89	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.46841736
90	GTP biosynthetic process (GO:0006183)	2.46704965
91	negative regulation of neurotransmitter transport (GO:0051589)	2.45266574
92	dendritic spine morphogenesis (GO:0060997)	2.44967943
93	regulation of timing of cell differentiation (GO:0048505)	2.44366872
94	negative regulation of membrane potential (GO:0045837)	2.42001262
95	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.41839411
96	behavioral response to cocaine (GO:0048148)	2.41781259
97	detection of light stimulus involved in sensory perception (GO:0050962)	2.40915053
98	detection of light stimulus involved in visual perception (GO:0050908)	2.40915053
99	microtubule-based movement (GO:0007018)	2.40721932
100	photoreceptor cell maintenance (GO:0045494)	2.40500181

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.56248616
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.55483979
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.25145946
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23093119
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.91857705
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.90646532
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.82192761
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76185806
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62678694
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.61227583
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59289638
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56960367
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36096475
14	P300_19829295_ChIP-Seq_ESCs_Human	2.28721929
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28220924
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.19502647
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.17888181
18	FUS_26573619_Chip-Seq_HEK293_Human	2.17217988
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.10782419
20	* EWS_26573619_Chip-Seq_HEK293_Human	2.08126398
21	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.01405342
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.88602384
23	VDR_22108803_ChIP-Seq_LS180_Human	1.88025802
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87884601
25	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.75968618
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.74332911
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74171273
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71566241
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60372964
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59443211
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58381554
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56711423
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55027837
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54881963
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54881963
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54679136
37	STAT3_23295773_ChIP-Seq_U87_Human	1.51888583
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49979976
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49818294
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.49725863
41	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.49395184
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.49224410
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49191763
44	AR_25329375_ChIP-Seq_VCAP_Human	1.48031171
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43747916
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.42612911
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42437061
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.41757766
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41757766
50	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39014750
51	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.38997887
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38614691
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.36487222
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33345608
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32747138
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32521517
57	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32244182
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.32234539
59	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.28983666
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27930662
61	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.27728053
62	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.27068344
63	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.25704893
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25145981
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24516332
66	* TCF4_23295773_ChIP-Seq_U87_Human	1.20101889
67	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17713667
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17116061
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17075573
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17023305
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15416854
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13943168
73	JUN_21703547_ChIP-Seq_K562_Human	1.12270265
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12229051
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.11931225
76	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.10275438
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10023323
78	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09683396
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08812685
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08790291
81	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08699989
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08484279
83	TP53_18474530_ChIP-ChIP_U2OS_Human	1.07739717
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06490660
85	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05555194
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05232781
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05232781
88	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.04586506
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04178777
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04090356
91	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02691940
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02637299
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02543712
94	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02308092
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.02040555
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01911758
97	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.01346530
98	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.01105777
99	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.00397848
100	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.00397848

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.74024440
2	MP0003011_delayed_dark_adaptation	3.36661575
3	MP0002653_abnormal_ependyma_morphology	3.36213961
4	MP0001984_abnormal_olfaction	3.32208837
5	MP0003880_abnormal_central_pattern	3.10797475
6	MP0000566_synostosis	2.89451818
7	MP0001529_abnormal_vocalization	2.84441083
8	MP0003122_maternal_imprinting	2.55029059
9	MP0002736_abnormal_nociception_after	2.41263124
10	MP0005171_absent_coat_pigmentation	2.36288728
11	MP0006276_abnormal_autonomic_nervous	2.30875717
12	MP0000778_abnormal_nervous_system	2.27568949
13	MP0005253_abnormal_eye_physiology	1.98264658
14	MP0005551_abnormal_eye_electrophysiolog	1.95605653
15	MP0001968_abnormal_touch/_nociception	1.93269530
16	MP0004133_heterotaxia	1.92124901
17	MP0006292_abnormal_olfactory_placode	1.87850292
18	MP0001486_abnormal_startle_reflex	1.86696185
19	MP0002638_abnormal_pupillary_reflex	1.85405961
20	MP0002938_white_spotting	1.85055770
21	MP0004859_abnormal_synaptic_plasticity	1.83747942
22	MP0005423_abnormal_somatic_nervous	1.80867595
23	MP0000569_abnormal_digit_pigmentation	1.74123272
24	MP0005394_taste/olfaction_phenotype	1.73673729
25	MP0005499_abnormal_olfactory_system	1.73673729
26	MP0009745_abnormal_behavioral_response	1.72291674
27	MP0004142_abnormal_muscle_tone	1.65032313
28	MP0002734_abnormal_mechanical_nocicepti	1.63994458
29	MP0008789_abnormal_olfactory_epithelium	1.62771165
30	MP0002102_abnormal_ear_morphology	1.60904309
31	MP0005248_abnormal_Harderian_gland	1.60727999
32	MP0006072_abnormal_retinal_apoptosis	1.59575539
33	MP0004270_analgesia	1.58970799
34	MP0002822_catalepsy	1.58903323
35	MP0002572_abnormal_emotion/affect_behav	1.55741839
36	MP0000026_abnormal_inner_ear	1.50573940
37	MP0000372_irregular_coat_pigmentation	1.49629220
38	MP0003121_genomic_imprinting	1.45695697
39	MP0003635_abnormal_synaptic_transmissio	1.45340943
40	MP0003890_abnormal_embryonic-extraembry	1.43932801
41	MP0002272_abnormal_nervous_system	1.41798080
42	MP0002064_seizures	1.40174429
43	MP0001293_anophthalmia	1.30983848
44	MP0002067_abnormal_sensory_capabilities	1.29790253
45	MP0002063_abnormal_learning/memory/cond	1.28825456
46	MP0001324_abnormal_eye_pigmentation	1.26730867
47	MP0001963_abnormal_hearing_physiology	1.26219653
48	MP0004885_abnormal_endolymph	1.25713818
49	MP0002557_abnormal_social/conspecific_i	1.23657484
50	MP0009697_abnormal_copulation	1.23037689
51	MP0000955_abnormal_spinal_cord	1.22998780
52	MP0001970_abnormal_pain_threshold	1.22099706
53	MP0002751_abnormal_autonomic_nervous	1.19129426
54	MP0001905_abnormal_dopamine_level	1.18775612
55	MP0000383_abnormal_hair_follicle	1.18348147
56	MP0001502_abnormal_circadian_rhythm	1.17810219
57	MP0001440_abnormal_grooming_behavior	1.16198786
58	MP0005391_vision/eye_phenotype	1.15158637
59	MP0001485_abnormal_pinna_reflex	1.14760823
60	MP0005187_abnormal_penis_morphology	1.13785754
61	MP0000631_abnormal_neuroendocrine_gland	1.13336088
62	MP0009046_muscle_twitch	1.13145632
63	MP0000647_abnormal_sebaceous_gland	1.12530946
64	MP0002928_abnormal_bile_duct	1.11316628
65	MP0002752_abnormal_somatic_nervous	1.07660937
66	MP0002882_abnormal_neuron_morphology	1.04897161
67	MP0000049_abnormal_middle_ear	1.04719453
68	MP0002233_abnormal_nose_morphology	1.03806985
69	MP0000534_abnormal_ureter_morphology	1.02591170
70	MP0002282_abnormal_trachea_morphology	1.01560465
71	MP0004019_abnormal_vitamin_homeostasis	0.99332225
72	MP0010030_abnormal_orbit_morphology	0.99306638
73	MP0004742_abnormal_vestibular_system	0.98874673
74	MP0005195_abnormal_posterior_eye	0.97842886
75	MP0002152_abnormal_brain_morphology	0.97804920
76	MP0003567_abnormal_fetal_cardiomyocyte	0.96011981
77	MP0002234_abnormal_pharynx_morphology	0.93718094
78	MP0002184_abnormal_innervation	0.93716099
79	MP0005167_abnormal_blood-brain_barrier	0.92767873
80	MP0003755_abnormal_palate_morphology	0.90732141
81	MP0003937_abnormal_limbs/digits/tail_de	0.90059120
82	MP0002733_abnormal_thermal_nociception	0.89743541
83	MP0002735_abnormal_chemical_nociception	0.89237213
84	MP0003633_abnormal_nervous_system	0.86293324
85	MP0001299_abnormal_eye_distance/	0.84701217
86	MP0002229_neurodegeneration	0.81348989
87	MP0003137_abnormal_impulse_conducting	0.81332089
88	MP0000538_abnormal_urinary_bladder	0.81323234
89	MP0003942_abnormal_urinary_system	0.80699815
90	MP0008877_abnormal_DNA_methylation	0.79561647
91	MP0005367_renal/urinary_system_phenotyp	0.79041664
92	MP0000516_abnormal_urinary_system	0.79041664
93	MP0002095_abnormal_skin_pigmentation	0.78986682
94	MP0003861_abnormal_nervous_system	0.78793531
95	MP0005386_behavior/neurological_phenoty	0.76707674
96	MP0004924_abnormal_behavior	0.76707674
97	MP0003631_nervous_system_phenotype	0.75959123
98	MP0000427_abnormal_hair_cycle	0.75188532
99	MP0002090_abnormal_vision	0.74163532
100	MP0008569_lethality_at_weaning	0.73676622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	5.00410368
2	Abnormal ciliary motility (HP:0012262)	4.46650589
3	Medial flaring of the eyebrow (HP:0010747)	4.40558708
4	Abnormal respiratory motile cilium physiology (HP:0012261)	4.39089392
5	Occipital encephalocele (HP:0002085)	4.33111417
6	Pancreatic fibrosis (HP:0100732)	4.31042414
7	Pancreatic cysts (HP:0001737)	4.18971838
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.14500817
9	Abnormality of midbrain morphology (HP:0002418)	4.08022693
10	Molar tooth sign on MRI (HP:0002419)	4.08022693
11	Hemiparesis (HP:0001269)	4.00968250
12	Gait imbalance (HP:0002141)	3.92746923
13	Congenital primary aphakia (HP:0007707)	3.82530196
14	Nephronophthisis (HP:0000090)	3.82213306
15	Abnormal respiratory epithelium morphology (HP:0012253)	3.80530682
16	Abnormal respiratory motile cilium morphology (HP:0005938)	3.80530682
17	Nephrogenic diabetes insipidus (HP:0009806)	3.58683329
18	Rhinitis (HP:0012384)	3.57362736
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.16102206
20	Cystic liver disease (HP:0006706)	3.15685277
21	Genital tract atresia (HP:0001827)	3.14136382
22	Vaginal atresia (HP:0000148)	3.13961734
23	Short tibia (HP:0005736)	3.04557224
24	Focal motor seizures (HP:0011153)	3.04130732
25	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.03017877
26	Polyphagia (HP:0002591)	3.01055613
27	Abnormality of the renal medulla (HP:0100957)	2.97473476
28	Chronic hepatic failure (HP:0100626)	2.89868214
29	Postaxial foot polydactyly (HP:0001830)	2.87757152
30	Postaxial hand polydactyly (HP:0001162)	2.84980751
31	Sclerocornea (HP:0000647)	2.78751500
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.71949966
33	Absent/shortened dynein arms (HP:0200106)	2.71949966
34	Hyperglycinemia (HP:0002154)	2.62024385
35	Poor coordination (HP:0002370)	2.61695115
36	Myokymia (HP:0002411)	2.61396821
37	Congenital hepatic fibrosis (HP:0002612)	2.58433231
38	Supernumerary spleens (HP:0009799)	2.57803370
39	Hemiplegia (HP:0002301)	2.54921243
40	Septo-optic dysplasia (HP:0100842)	2.52786914
41	Anencephaly (HP:0002323)	2.51128388
42	Abnormality of the labia minora (HP:0012880)	2.50286036
43	Abnormal biliary tract physiology (HP:0012439)	2.47162074
44	Bile duct proliferation (HP:0001408)	2.47162074
45	Narrow forehead (HP:0000341)	2.44551148
46	Tubulointerstitial nephritis (HP:0001970)	2.42918615
47	Oculomotor apraxia (HP:0000657)	2.40375410
48	Broad foot (HP:0001769)	2.39033568
49	Tubular atrophy (HP:0000092)	2.38055758
50	Preaxial hand polydactyly (HP:0001177)	2.37387802
51	Male pseudohermaphroditism (HP:0000037)	2.30205015
52	Action tremor (HP:0002345)	2.29705255
53	Keratoconus (HP:0000563)	2.26737423
54	Increased corneal curvature (HP:0100692)	2.26737423
55	Mitochondrial inheritance (HP:0001427)	2.20639171
56	Decreased central vision (HP:0007663)	2.19279064
57	Hypomagnesemia (HP:0002917)	2.19014148
58	Acute necrotizing encephalopathy (HP:0006965)	2.18221253
59	Specific learning disability (HP:0001328)	2.16342165
60	Aplasia/Hypoplasia of the lens (HP:0008063)	2.14975272
61	Type 2 muscle fiber atrophy (HP:0003554)	2.12214940
62	Hyperventilation (HP:0002883)	2.09185090
63	Retinal dysplasia (HP:0007973)	2.08102914
64	Optic nerve hypoplasia (HP:0000609)	2.04198439
65	Sensorimotor neuropathy (HP:0007141)	2.03795825
66	Lipid accumulation in hepatocytes (HP:0006561)	2.03099607
67	Bifid tongue (HP:0010297)	2.02348176
68	Abnormality of glycine metabolism (HP:0010895)	2.00158002
69	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00158002
70	Colon cancer (HP:0003003)	1.99786825
71	Increased hepatocellular lipid droplets (HP:0006565)	1.99371453
72	Epidermoid cyst (HP:0200040)	1.98971155
73	Progressive macrocephaly (HP:0004481)	1.98953336
74	Tubulointerstitial abnormality (HP:0001969)	1.98234831
75	Acute encephalopathy (HP:0006846)	1.97641625
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92203439
77	Furrowed tongue (HP:0000221)	1.90971557
78	Polyuria (HP:0000103)	1.88095111
79	Bronchiectasis (HP:0002110)	1.87663308
80	Prominent nasal bridge (HP:0000426)	1.87567168
81	Left ventricular hypertrophy (HP:0001712)	1.87398206
82	Progressive cerebellar ataxia (HP:0002073)	1.87123490
83	Hyperglycinuria (HP:0003108)	1.86973409
84	Abnormality of the renal cortex (HP:0011035)	1.82646309
85	Anophthalmia (HP:0000528)	1.82315234
86	Median cleft lip (HP:0000161)	1.81815145
87	Aganglionic megacolon (HP:0002251)	1.80732999
88	Absent septum pellucidum (HP:0001331)	1.78662719
89	Chronic bronchitis (HP:0004469)	1.78581375
90	Decreased testicular size (HP:0008734)	1.78169240
91	Exercise-induced muscle cramps (HP:0003710)	1.78085572
92	Split foot (HP:0001839)	1.75874369
93	Cerebellar dysplasia (HP:0007033)	1.75843972
94	Increased CSF lactate (HP:0002490)	1.74967964
95	Drooling (HP:0002307)	1.72778931
96	Abnormal eating behavior (HP:0100738)	1.72584745
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70931929
98	Large for gestational age (HP:0001520)	1.70039257
99	Polydipsia (HP:0001959)	1.68884569
100	Abnormal drinking behavior (HP:0030082)	1.68884569

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.90286950
2	MARK1	3.67148512
3	TNIK	2.91187275
4	MAP3K4	2.68233563
5	WNK3	2.67772455
6	BCKDK	2.28043459
7	MAP2K7	2.25103597
8	BMPR1B	2.23801567
9	MAPK13	2.12456447
10	MST4	2.12258491
11	NTRK2	2.07588231
12	MAP4K2	2.05446059
13	BCR	1.99410340
14	CSNK1G2	1.98349971
15	PLK2	1.95253800
16	CCNB1	1.86888664
17	PINK1	1.84532410
18	FRK	1.81858457
19	CSNK1G3	1.78068594
20	PBK	1.64474022
21	ERBB3	1.64460707
22	MAPK15	1.64065237
23	CSNK1G1	1.59885661
24	ADRBK2	1.57118504
25	DYRK2	1.56307215
26	CSNK1A1L	1.52516995
27	DYRK3	1.47446112
28	TRIM28	1.46736056
29	FGFR2	1.45069915
30	PTK2B	1.35759071
31	EPHA4	1.29049172
32	NEK9	1.23595385
33	EPHA3	1.23151156
34	PNCK	1.21259977
35	EPHB1	1.15190158
36	STK39	1.08231477
37	PDK2	0.99387632
38	SRPK1	0.96060804
39	PRKCE	0.96056818
40	ERBB4	0.96049342
41	MKNK2	0.95665704
42	STK38L	0.94167681
43	MUSK	0.93829248
44	DYRK1A	0.92950665
45	MKNK1	0.88615416
46	TAOK1	0.86055209
47	WNK4	0.85466393
48	GRK1	0.83109880
49	RPS6KA4	0.82833984
50	WEE1	0.81727306
51	PAK6	0.80465828
52	NTRK3	0.77395453
53	PRKCG	0.75852096
54	EPHB2	0.75054222
55	PAK3	0.74804451
56	LMTK2	0.73403979
57	CAMK2A	0.72461871
58	MAP2K4	0.71759116
59	STK16	0.70078164
60	PHKG2	0.68207895
61	PHKG1	0.68207895
62	ROCK2	0.67733761
63	BRD4	0.66951227
64	CDK19	0.64301239
65	UHMK1	0.62610846
66	MINK1	0.58847888
67	SGK494	0.55151099
68	SGK223	0.55151099
69	CSNK1A1	0.55123832
70	PRKACA	0.53288822
71	VRK1	0.53185566
72	PRKD3	0.52936678
73	PRKG1	0.50743693
74	MET	0.50658313
75	CDK5	0.49741808
76	ERBB2	0.49559097
77	NEK1	0.48593200
78	FER	0.46771920
79	TGFBR1	0.46298452
80	CAMK2B	0.46021257
81	ACVR1B	0.45494282
82	LIMK1	0.45477578
83	SGK2	0.42928141
84	CAMKK2	0.42820246
85	RPS6KA5	0.42150105
86	INSRR	0.41954792
87	CDK3	0.41931096
88	OXSR1	0.40883773
89	PASK	0.40211475
90	CAMK2D	0.39355355
91	CDK14	0.39244736
92	NEK6	0.38524727
93	PKN1	0.38469695
94	PLK3	0.35784015
95	TAOK3	0.35153939
96	PRKACB	0.34032662
97	DYRK1B	0.31729422
98	OBSCN	0.30536688
99	CDK18	0.30307645
100	PRKACG	0.27789872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.00789460
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.08635489
3	Protein export_Homo sapiens_hsa03060	2.94231418
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.74998325
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.53736205
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.45983813
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.45422744
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44052087
9	Propanoate metabolism_Homo sapiens_hsa00640	2.43225668
10	Parkinsons disease_Homo sapiens_hsa05012	2.35946025
11	Butanoate metabolism_Homo sapiens_hsa00650	2.28957500
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27012259
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23445562
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.20737005
15	Nicotine addiction_Homo sapiens_hsa05033	2.18176173
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.96327108
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.90175220
18	Huntingtons disease_Homo sapiens_hsa05016	1.84407647
19	Fatty acid elongation_Homo sapiens_hsa00062	1.82097084
20	Peroxisome_Homo sapiens_hsa04146	1.63027730
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.61608488
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59634680
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54655193
24	Alzheimers disease_Homo sapiens_hsa05010	1.51323260
25	Phototransduction_Homo sapiens_hsa04744	1.51195823
26	Cocaine addiction_Homo sapiens_hsa05030	1.37575021
27	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.29915979
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.27254657
29	GABAergic synapse_Homo sapiens_hsa04727	1.26843126
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20346383
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20263681
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15977731
33	Fatty acid degradation_Homo sapiens_hsa00071	1.15124289
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.09410235
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.07030167
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.06562279
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.04432988
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.03498275
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02931065
40	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.02462339
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00975376
42	Dopaminergic synapse_Homo sapiens_hsa04728	1.00319075
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.97594766
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97522786
45	Axon guidance_Homo sapiens_hsa04360	0.97014440
46	Morphine addiction_Homo sapiens_hsa05032	0.93189639
47	Circadian entrainment_Homo sapiens_hsa04713	0.92547851
48	Taste transduction_Homo sapiens_hsa04742	0.91334569
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89642516
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88919843
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87463848
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85766785
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85521524
54	RNA polymerase_Homo sapiens_hsa03020	0.79037075
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79016088
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74806007
57	Carbon metabolism_Homo sapiens_hsa01200	0.73768933
58	Serotonergic synapse_Homo sapiens_hsa04726	0.73591624
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73081951
60	Olfactory transduction_Homo sapiens_hsa04740	0.72304487
61	Metabolic pathways_Homo sapiens_hsa01100	0.70253954
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67451533
63	Amphetamine addiction_Homo sapiens_hsa05031	0.64680982
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.63800059
65	Basal transcription factors_Homo sapiens_hsa03022	0.63792255
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63447667
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.63431639
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.63327535
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.61789543
70	RNA degradation_Homo sapiens_hsa03018	0.61703337
71	Retinol metabolism_Homo sapiens_hsa00830	0.61682524
72	Regulation of autophagy_Homo sapiens_hsa04140	0.60893047
73	Folate biosynthesis_Homo sapiens_hsa00790	0.60809442
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58312280
75	Insulin secretion_Homo sapiens_hsa04911	0.56672066
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55744094
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54838519
78	Histidine metabolism_Homo sapiens_hsa00340	0.54443284
79	Glutathione metabolism_Homo sapiens_hsa00480	0.51499504
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48233378
81	Caffeine metabolism_Homo sapiens_hsa00232	0.45725516
82	Gap junction_Homo sapiens_hsa04540	0.44263684
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40452085
84	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39453529
85	Alcoholism_Homo sapiens_hsa05034	0.38606668
86	Circadian rhythm_Homo sapiens_hsa04710	0.37444014
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36267905
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.33783358
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33353519
90	Melanogenesis_Homo sapiens_hsa04916	0.33046438
91	Gastric acid secretion_Homo sapiens_hsa04971	0.30839566
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30748443
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.30362123
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29665604
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29118089
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27051898
97	Purine metabolism_Homo sapiens_hsa00230	0.25633995
98	ABC transporters_Homo sapiens_hsa02010	0.25463688
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24753457
100	Lysine degradation_Homo sapiens_hsa00310	0.23599685

C21ORF62

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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