C21ORF91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.66901527
2response to interleukin-15 (GO:0070672)3.77051444
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69911786
4negative regulation of thymocyte apoptotic process (GO:0070244)3.69685350
5positive regulation of gamma-delta T cell activation (GO:0046645)3.62427027
6cellular response to interleukin-15 (GO:0071350)3.57746189
7attachment of spindle microtubules to kinetochore (GO:0008608)3.49243027
8melanin metabolic process (GO:0006582)3.43919057
9rRNA methylation (GO:0031167)3.36926599
10melanin biosynthetic process (GO:0042438)3.33713058
11interferon-gamma production (GO:0032609)3.27981650
12mitotic G2 DNA damage checkpoint (GO:0007095)3.24236956
13pore complex assembly (GO:0046931)3.23562978
14secondary metabolite biosynthetic process (GO:0044550)3.23232841
15histone mRNA catabolic process (GO:0071044)3.22783653
16nuclear pore complex assembly (GO:0051292)3.16775211
17mitotic G2/M transition checkpoint (GO:0044818)3.16560329
18mitotic sister chromatid cohesion (GO:0007064)3.16441519
19nuclear pore organization (GO:0006999)3.13243156
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12553669
21positive regulation of B cell differentiation (GO:0045579)3.12410564
22positive regulation of granulocyte differentiation (GO:0030854)3.10253137
23CENP-A containing nucleosome assembly (GO:0034080)3.09444675
24negative T cell selection (GO:0043383)3.09123323
25regulation of fibroblast apoptotic process (GO:2000269)3.08036135
26histone exchange (GO:0043486)3.07012370
27rRNA modification (GO:0000154)3.02064147
28negative regulation of B cell proliferation (GO:0030889)3.01917558
29positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01504799
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99134711
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97029432
32negative thymic T cell selection (GO:0045060)2.96895558
33DNA double-strand break processing (GO:0000729)2.93405406
34chromatin remodeling at centromere (GO:0031055)2.93251286
35regulation of alpha-beta T cell proliferation (GO:0046640)2.93231961
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84948656
37regulation of mitotic spindle checkpoint (GO:1903504)2.84948656
38V(D)J recombination (GO:0033151)2.83271034
39regulation of isotype switching to IgG isotypes (GO:0048302)2.81088983
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76163516
41isotype switching (GO:0045190)2.76163516
42somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76163516
43regulation of B cell differentiation (GO:0045577)2.76089709
44T cell migration (GO:0072678)2.76034620
45spindle checkpoint (GO:0031577)2.70687961
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.70612243
47negative regulation of DNA-dependent DNA replication (GO:2000104)2.70085962
48negative regulation of fibroblast apoptotic process (GO:2000270)2.69888665
49ribosome assembly (GO:0042255)2.69217727
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69029057
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69029057
52positive regulation of mitotic sister chromatid separation (GO:1901970)2.69029057
53regulation of gamma-delta T cell differentiation (GO:0045586)2.68401081
54hepatocyte apoptotic process (GO:0097284)2.65940144
55definitive hemopoiesis (GO:0060216)2.65713904
56sister chromatid segregation (GO:0000819)2.65446950
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64571360
58centriole replication (GO:0007099)2.63549451
59somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.61605517
60somatic cell DNA recombination (GO:0016444)2.61605517
61regulation of gamma-delta T cell activation (GO:0046643)2.61509876
62regulation of DNA endoreduplication (GO:0032875)2.61401566
63mast cell activation (GO:0045576)2.60141631
64DNA demethylation (GO:0080111)2.59331062
65mast cell activation involved in immune response (GO:0002279)2.58814366
66mast cell degranulation (GO:0043303)2.58814366
67regulation of T-helper 1 cell differentiation (GO:0045625)2.58315585
68mitotic spindle checkpoint (GO:0071174)2.58068786
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57806864
70negative regulation of cell killing (GO:0031342)2.57806864
71protein K11-linked deubiquitination (GO:0035871)2.57422665
72protein targeting to Golgi (GO:0000042)2.54991044
73negative regulation of mitotic sister chromatid separation (GO:2000816)2.51369094
74negative regulation of sister chromatid segregation (GO:0033046)2.51369094
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.51369094
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51369094
77negative regulation of mitotic sister chromatid segregation (GO:0033048)2.51369094
78keratinocyte development (GO:0003334)2.51186034
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50980987
80histamine secretion (GO:0001821)2.50100410
81histone mRNA metabolic process (GO:0008334)2.49884068
82establishment of protein localization to Golgi (GO:0072600)2.49736828
83regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49585863
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49585863
85N-terminal protein amino acid acetylation (GO:0006474)2.49010378
86regulation of sister chromatid segregation (GO:0033045)2.48975173
87regulation of mitotic sister chromatid separation (GO:0010965)2.48975173
88regulation of mitotic sister chromatid segregation (GO:0033047)2.48975173
89somatic diversification of immune receptors (GO:0002200)2.48812154
90negative regulation of T cell apoptotic process (GO:0070233)2.47612571
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47588275
92inositol phosphate dephosphorylation (GO:0046855)2.47588275
93negative regulation of chromosome segregation (GO:0051985)2.45818969
94T cell homeostasis (GO:0043029)2.45517874
95sister chromatid cohesion (GO:0007062)2.45456334
96inositol phosphate catabolic process (GO:0071545)2.45011292
97single strand break repair (GO:0000012)2.42073887
98neural tube formation (GO:0001841)2.40909411
99B cell proliferation (GO:0042100)2.40740117
100negative regulation of neurotransmitter secretion (GO:0046929)2.39557022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10180675
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11962253
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.80932001
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71444831
5GATA1_22025678_ChIP-Seq_K562_Human2.55719023
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.52327431
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.40505165
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36480483
9* IRF8_22096565_ChIP-ChIP_GC-B_Human2.35739814
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30385572
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27609595
12FUS_26573619_Chip-Seq_HEK293_Human2.25720895
13ELK1_19687146_ChIP-ChIP_HELA_Human2.24952594
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21293316
15E2F7_22180533_ChIP-Seq_HELA_Human2.20050524
16EWS_26573619_Chip-Seq_HEK293_Human2.13380306
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.07693272
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07622089
19VDR_23849224_ChIP-Seq_CD4+_Human2.04247985
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.00248468
21MYB_26560356_Chip-Seq_TH2_Human1.94501888
22VDR_22108803_ChIP-Seq_LS180_Human1.93555820
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.91273590
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83478073
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81129682
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.77945658
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74333780
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73304989
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70340159
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68837765
31RUNX_20019798_ChIP-Seq_JUKART_Human1.68447769
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66082816
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.63549330
34IGF1R_20145208_ChIP-Seq_DFB_Human1.62547782
35TAF15_26573619_Chip-Seq_HEK293_Human1.61919021
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56590593
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.54375573
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54045818
39SCL_19346495_ChIP-Seq_HPC-7_Human1.51879443
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51155457
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49399799
42* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49241623
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48249948
44P300_19829295_ChIP-Seq_ESCs_Human1.47822718
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46494534
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.45851740
47MYB_26560356_Chip-Seq_TH1_Human1.44622159
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39382549
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38730650
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.34243971
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32828576
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30770653
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24910636
54ZNF274_21170338_ChIP-Seq_K562_Hela1.24043957
55* GATA3_26560356_Chip-Seq_TH2_Human1.22202515
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21616451
57ER_23166858_ChIP-Seq_MCF-7_Human1.17484622
58MYC_18940864_ChIP-ChIP_HL60_Human1.17390742
59SPI1_23547873_ChIP-Seq_NB4_Human1.17388186
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17094687
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16939038
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16714938
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16173742
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13641748
65GATA3_27048872_Chip-Seq_THYMUS_Human1.12851920
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.12749557
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09673798
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.09572129
69IRF1_19129219_ChIP-ChIP_H3396_Human1.08718501
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08145133
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07601553
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07185457
73CBP_20019798_ChIP-Seq_JUKART_Human1.07185457
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.05549193
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04599151
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.03599687
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03201480
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02159095
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00886246
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99149046
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98854790
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.97142179
83IRF8_27001747_Chip-Seq_BMDM_Mouse0.96552727
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.95746411
85SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95678080
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95008865
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94437119
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94175699
89GATA3_26560356_Chip-Seq_TH1_Human0.92511944
90OCT4_18555785_Chip-Seq_ESCs_Mouse0.91618561
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.91585707
92CMYC_18555785_Chip-Seq_ESCs_Mouse0.91394963
93SOX2_19829295_ChIP-Seq_ESCs_Human0.91194814
94NANOG_19829295_ChIP-Seq_ESCs_Human0.91194814
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91064841
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90774261
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90638680
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89867660
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89706012
100P300_18555785_Chip-Seq_ESCs_Mouse0.89541295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.73605513
2MP0008057_abnormal_DNA_replication4.14000219
3MP0005075_abnormal_melanosome_morpholog3.49567946
4MP0005671_abnormal_response_to3.16217505
5MP0001835_abnormal_antigen_presentation3.09518169
6MP0010094_abnormal_chromosome_stability2.97572161
7MP0003763_abnormal_thymus_physiology2.97391855
8MP0000015_abnormal_ear_pigmentation2.56691460
9MP0008877_abnormal_DNA_methylation2.56651895
10MP0002166_altered_tumor_susceptibility2.55552238
11MP0004381_abnormal_hair_follicle2.48160667
12MP0002396_abnormal_hematopoietic_system2.33890174
13MP0001800_abnormal_humoral_immune2.23456881
14MP0002095_abnormal_skin_pigmentation2.04192074
15MP0002006_tumorigenesis2.03803009
16MP0003136_yellow_coat_color2.01219949
17MP0004957_abnormal_blastocyst_morpholog1.98335610
18MP0009785_altered_susceptibility_to1.95073390
19MP0008058_abnormal_DNA_repair1.94861769
20MP0002398_abnormal_bone_marrow1.84015939
21MP0000703_abnormal_thymus_morphology1.76265253
22MP0005000_abnormal_immune_tolerance1.72921757
23MP0002102_abnormal_ear_morphology1.72669811
24MP0006054_spinal_hemorrhage1.71781278
25MP0003077_abnormal_cell_cycle1.71287806
26MP0003111_abnormal_nucleus_morphology1.68620015
27MP0000685_abnormal_immune_system1.65232673
28MP0005408_hypopigmentation1.64524210
29MP0002723_abnormal_immune_serum1.64473546
30MP0005174_abnormal_tail_pigmentation1.64377578
31MP0000689_abnormal_spleen_morphology1.63378911
32MP0003890_abnormal_embryonic-extraembry1.56605848
33MP0003724_increased_susceptibility_to1.56416034
34MP0002420_abnormal_adaptive_immunity1.54125875
35MP0000465_gastrointestinal_hemorrhage1.53854558
36MP0001819_abnormal_immune_cell1.53440719
37MP0005387_immune_system_phenotype1.51402493
38MP0001790_abnormal_immune_system1.51402493
39MP0009697_abnormal_copulation1.50284606
40MP0002452_abnormal_antigen_presenting1.48530147
41MP0003787_abnormal_imprinting1.47936867
42MP0003693_abnormal_embryo_hatching1.47528956
43MP0002722_abnormal_immune_system1.47112574
44MP0005171_absent_coat_pigmentation1.45531783
45MP0000716_abnormal_immune_system1.44270044
46MP0000569_abnormal_digit_pigmentation1.41214784
47MP0002148_abnormal_hypersensitivity_rea1.40384924
48MP0003195_calcinosis1.34070148
49MP0002405_respiratory_system_inflammati1.32347271
50MP0009333_abnormal_splenocyte_physiolog1.31250638
51MP0001324_abnormal_eye_pigmentation1.30745763
52MP0003221_abnormal_cardiomyocyte_apopto1.30648172
53MP0002009_preneoplasia1.28092059
54MP0002254_reproductive_system_inflammat1.23146219
55MP0000371_diluted_coat_color1.22848616
56MP0004808_abnormal_hematopoietic_stem1.21522641
57MP0002429_abnormal_blood_cell1.19676090
58MP0001188_hyperpigmentation1.17067755
59MP0005025_abnormal_response_to1.13996229
60MP0003567_abnormal_fetal_cardiomyocyte1.12678222
61MP0010307_abnormal_tumor_latency1.05540034
62MP0005464_abnormal_platelet_physiology1.00250051
63MP0003718_maternal_effect0.99924138
64MP0002019_abnormal_tumor_incidence0.99345551
65MP0010155_abnormal_intestine_physiology0.98509039
66MP0005397_hematopoietic_system_phenotyp0.97442213
67MP0001545_abnormal_hematopoietic_system0.97442213
68MP0002638_abnormal_pupillary_reflex0.93969676
69MP0003943_abnormal_hepatobiliary_system0.92720165
70MP0003806_abnormal_nucleotide_metabolis0.91701479
71MP0001929_abnormal_gametogenesis0.87970336
72MP0002419_abnormal_innate_immunity0.87006208
73MP0005310_abnormal_salivary_gland0.81673170
74MP0001293_anophthalmia0.81315845
75MP0002277_abnormal_respiratory_mucosa0.77289662
76MP0001191_abnormal_skin_condition0.76164421
77MP0001845_abnormal_inflammatory_respons0.76136221
78MP0000427_abnormal_hair_cycle0.74947685
79MP0005451_abnormal_body_composition0.74839628
80MP0006292_abnormal_olfactory_placode0.74632243
81MP0002132_abnormal_respiratory_system0.74070253
82MP0005253_abnormal_eye_physiology0.74019071
83MP0000350_abnormal_cell_proliferation0.73603786
84MP0003786_premature_aging0.69374911
85MP0001851_eye_inflammation0.66953040
86MP0006036_abnormal_mitochondrial_physio0.66636553
87MP0004947_skin_inflammation0.65922553
88MP0001919_abnormal_reproductive_system0.65832310
89MP0003866_abnormal_defecation0.65666903
90MP0006035_abnormal_mitochondrial_morpho0.64778228
91MP0000313_abnormal_cell_death0.64755154
92MP0008932_abnormal_embryonic_tissue0.63691735
93MP0001119_abnormal_female_reproductive0.63595112
94MP0001730_embryonic_growth_arrest0.63329326
95MP0003646_muscle_fatigue0.63003943
96MP0008007_abnormal_cellular_replicative0.62031156
97MP0001697_abnormal_embryo_size0.61273059
98MP0005084_abnormal_gallbladder_morpholo0.59860192
99MP0002075_abnormal_coat/hair_pigmentati0.59736507
100MP0003436_decreased_susceptibility_to0.58385410

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.09565128
2T lymphocytopenia (HP:0005403)5.09096833
3Abnormality of B cell number (HP:0010975)4.82039849
4Abnormality of T cell number (HP:0011839)4.72005660
5Severe combined immunodeficiency (HP:0004430)4.42447651
6Thyroiditis (HP:0100646)4.27994727
7Panhypogammaglobulinemia (HP:0003139)4.27642619
8Combined immunodeficiency (HP:0005387)3.79356853
9Autoimmune hemolytic anemia (HP:0001890)3.71514728
10Stomatitis (HP:0010280)3.57946476
11Abnormality of T cells (HP:0002843)3.37926717
12Volvulus (HP:0002580)3.35908624
13IgG deficiency (HP:0004315)3.35511826
14Hypoplasia of the thymus (HP:0000778)3.30055351
15Eosinophilia (HP:0001880)3.14205807
16Hypoproteinemia (HP:0003075)2.99150054
17Abnormality of eosinophils (HP:0001879)2.95277998
18Abnormality of macular pigmentation (HP:0008002)2.82334445
19Recurrent viral infections (HP:0004429)2.81682283
20Reduced antithrombin III activity (HP:0001976)2.72316074
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.68198494
22Recurrent fungal infections (HP:0002841)2.68026824
23Hypoplasia of the fovea (HP:0007750)2.54568983
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.54568983
25Granulocytopenia (HP:0001913)2.53886160
26Dyschromatopsia (HP:0007641)2.50473172
27Aplasia/Hypoplasia of the macula (HP:0008059)2.46822996
28Abnormality of chromosome stability (HP:0003220)2.46656664
29Abnormality of the fovea (HP:0000493)2.44143373
30Progressive inability to walk (HP:0002505)2.44094903
31Pancreatic islet-cell hyperplasia (HP:0004510)2.43415528
32Abnormality of the prostate (HP:0008775)2.39874807
33Leukocytosis (HP:0001974)2.38815899
34Acute myeloid leukemia (HP:0004808)2.34334189
35IgM deficiency (HP:0002850)2.29568650
36Abnormal auditory evoked potentials (HP:0006958)2.28235862
37Abnormality of T cell physiology (HP:0011840)2.27977923
38Abnormality of the pancreatic islet cells (HP:0006476)2.26217982
39Abnormality of endocrine pancreas physiology (HP:0012093)2.26217982
40Nephroblastoma (Wilms tumor) (HP:0002667)2.23866188
41Patchy hypopigmentation of hair (HP:0011365)2.22689059
42Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22438662
43Stomach cancer (HP:0012126)2.18485377
44Erythroderma (HP:0001019)2.17031316
45Embryonal renal neoplasm (HP:0011794)2.15603539
46Lymphoma (HP:0002665)2.14735860
47Meningitis (HP:0001287)2.12443232
48Neoplasm of the adrenal cortex (HP:0100641)2.11613939
49Ocular albinism (HP:0001107)2.09936978
50Cutaneous melanoma (HP:0012056)2.09846409
51Rhabdomyosarcoma (HP:0002859)2.09795661
52Myelodysplasia (HP:0002863)1.98984120
53Gastrointestinal infarctions (HP:0005244)1.97942720
54Hypoglycemic seizures (HP:0002173)1.96922023
55Albinism (HP:0001022)1.96683902
56Recurrent cutaneous fungal infections (HP:0011370)1.95658686
57Chronic mucocutaneous candidiasis (HP:0002728)1.95658686
58Acute lymphatic leukemia (HP:0006721)1.93093290
59Abnormality of the columella (HP:0009929)1.92886013
60Aplasia/Hypoplasia of the thymus (HP:0010515)1.92778625
61Iris hypopigmentation (HP:0007730)1.92233224
62Abnormal lung lobation (HP:0002101)1.89815386
63Prostate neoplasm (HP:0100787)1.88196842
64Central scotoma (HP:0000603)1.88099467
65Abnormality of the thymus (HP:0000777)1.88050330
66Generalized hypopigmentation (HP:0007513)1.86907586
67Facial hemangioma (HP:0000329)1.86325599
68Abnormal glycosylation (HP:0012345)1.82714923
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82714923
70Abnormal protein N-linked glycosylation (HP:0012347)1.82714923
71Abnormal protein glycosylation (HP:0012346)1.82714923
72Recurrent bronchitis (HP:0002837)1.82055753
73IgA deficiency (HP:0002720)1.79833683
74Clubbing of toes (HP:0100760)1.79522153
75Agammaglobulinemia (HP:0004432)1.78884354
76Freckling (HP:0001480)1.78873982
77Decreased central vision (HP:0007663)1.77694531
78Thyroid carcinoma (HP:0002890)1.76562030
79Amaurosis fugax (HP:0100576)1.74135230
80Sensory axonal neuropathy (HP:0003390)1.73541629
81Elevated erythrocyte sedimentation rate (HP:0003565)1.73053934
82Thoracolumbar scoliosis (HP:0002944)1.72927693
83Keratoconjunctivitis sicca (HP:0001097)1.72804364
84Methylmalonic acidemia (HP:0002912)1.71034288
85Capillary hemangiomas (HP:0005306)1.69607568
86Abnormality of the preputium (HP:0100587)1.68928642
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.67985152
88Chest pain (HP:0100749)1.67904989
89Colon cancer (HP:0003003)1.67815977
90Retrobulbar optic neuritis (HP:0100654)1.66951091
91Optic neuritis (HP:0100653)1.66951091
92White forelock (HP:0002211)1.66820747
93Keratoconjunctivitis (HP:0001096)1.66808272
94Bronchitis (HP:0012387)1.65905015
95Hyperinsulinemic hypoglycemia (HP:0000825)1.65300203
96Abnormality of methionine metabolism (HP:0010901)1.65060963
97Aqueductal stenosis (HP:0002410)1.63667090
98Lymphopenia (HP:0001888)1.63194115
99Papillary thyroid carcinoma (HP:0002895)1.61298922
100Small intestinal stenosis (HP:0012848)1.60300460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.31778541
2TXK3.20211950
3TRIM282.93187208
4TNIK2.53659969
5ACVR1B2.52769074
6FRK2.46465145
7NUAK12.38767915
8SIK32.35499118
9BMPR1B2.18429021
10MST42.16631407
11MARK32.12454462
12NEK12.08749780
13NLK2.03952722
14MKNK22.03027879
15MKNK11.92685932
16PLK41.87773563
17BUB11.81500170
18BRD41.65843645
19TAF11.62508902
20WEE11.59379865
21TEC1.58428920
22PLK31.57924436
23MAP3K141.55797498
24ZAK1.49484242
25STK31.43874434
26MAP4K11.40806273
27NEK21.39638851
28BCR1.35979037
29BMPR21.34170012
30WNK31.30982035
31ERBB31.29539490
32CDK61.28584546
33PASK1.28027508
34TGFBR11.27352943
35DYRK31.22849474
36TAOK31.21145189
37CDC71.19550472
38BRSK21.14792731
39TYK21.12557018
40JAK31.10157208
41TTK1.09941723
42STK38L1.08888736
43ITK1.08496420
44STK241.08442441
45IKBKE1.06439756
46JAK11.02897417
47RIPK40.98887872
48PLK20.97220891
49SRPK10.95810708
50EIF2AK20.95650730
51STK100.93155437
52VRK10.92424038
53PBK0.91326266
54KIT0.89965431
55CLK10.87608896
56TSSK60.87089044
57MELK0.84739049
58BTK0.81869444
59IRAK40.79558266
60STK40.78944343
61EIF2AK10.72021961
62FGFR20.71145197
63PRKCQ0.68921862
64HCK0.68518156
65FGFR30.68487581
66SYK0.67053182
67CDK30.65859636
68ATR0.64424785
69LCK0.62551230
70IKBKB0.62399123
71PLK10.61970833
72LYN0.61063457
73YES10.60649930
74MAP3K100.59047387
75ATM0.58886459
76FES0.58369566
77AKT30.57893806
78MAP3K120.56590819
79PIK3CG0.56299144
80PINK10.54728182
81RPS6KA40.52961047
82GRK60.50871293
83IRAK10.50450723
84VRK20.50434418
85MAP3K50.49118243
86CSK0.47993880
87LATS10.47617427
88WNK10.47265374
89MATK0.46447087
90PIM10.45168160
91RPS6KB10.38689503
92FGR0.37454084
93CHEK10.36941909
94CDK40.35035177
95CSNK1G10.34634088
96DAPK10.32894818
97EGFR0.32686967
98MAPK130.32295200
99NME10.30862049
100MAP3K40.30691728

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.73887915
2Primary immunodeficiency_Homo sapiens_hsa053403.50397524
3Basal transcription factors_Homo sapiens_hsa030222.60946075
4Measles_Homo sapiens_hsa051622.52762382
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48344082
6Proteasome_Homo sapiens_hsa030502.43651172
7RNA degradation_Homo sapiens_hsa030182.29695210
8Allograft rejection_Homo sapiens_hsa053302.03333323
9Graft-versus-host disease_Homo sapiens_hsa053321.91157275
10RNA transport_Homo sapiens_hsa030131.90785884
11Herpes simplex infection_Homo sapiens_hsa051681.85821450
12T cell receptor signaling pathway_Homo sapiens_hsa046601.85477061
13Fanconi anemia pathway_Homo sapiens_hsa034601.84660236
14Homologous recombination_Homo sapiens_hsa034401.82879899
15Autoimmune thyroid disease_Homo sapiens_hsa053201.78299445
16Selenocompound metabolism_Homo sapiens_hsa004501.77760595
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76864887
18Regulation of autophagy_Homo sapiens_hsa041401.75860988
19Cell cycle_Homo sapiens_hsa041101.75413582
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74015492
21mRNA surveillance pathway_Homo sapiens_hsa030151.64183049
22Protein export_Homo sapiens_hsa030601.61892724
23Type I diabetes mellitus_Homo sapiens_hsa049401.57760799
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.57503328
25p53 signaling pathway_Homo sapiens_hsa041151.55368241
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55284870
27Mismatch repair_Homo sapiens_hsa034301.51361593
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51177324
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48743608
30Spliceosome_Homo sapiens_hsa030401.41856295
31Hematopoietic cell lineage_Homo sapiens_hsa046401.38725255
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34631033
33RNA polymerase_Homo sapiens_hsa030201.30581809
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29801050
35Oocyte meiosis_Homo sapiens_hsa041141.20280126
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.19003247
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17855732
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17589499
39B cell receptor signaling pathway_Homo sapiens_hsa046621.16528037
40Antigen processing and presentation_Homo sapiens_hsa046121.11580007
41Legionellosis_Homo sapiens_hsa051341.09650253
42Hepatitis B_Homo sapiens_hsa051611.08884309
43Propanoate metabolism_Homo sapiens_hsa006401.07418820
44Influenza A_Homo sapiens_hsa051640.99297785
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98847453
46Dorso-ventral axis formation_Homo sapiens_hsa043200.98037517
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96756183
48Nucleotide excision repair_Homo sapiens_hsa034200.93907414
49Olfactory transduction_Homo sapiens_hsa047400.93446409
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90658404
51Leishmaniasis_Homo sapiens_hsa051400.86960063
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85017450
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84403703
54Inositol phosphate metabolism_Homo sapiens_hsa005620.83441418
55Platelet activation_Homo sapiens_hsa046110.83267881
56DNA replication_Homo sapiens_hsa030300.82567906
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.81129138
58Viral carcinogenesis_Homo sapiens_hsa052030.80402984
59Osteoclast differentiation_Homo sapiens_hsa043800.78973185
60Thyroid cancer_Homo sapiens_hsa052160.78804158
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78379323
62Prostate cancer_Homo sapiens_hsa052150.77494285
63Base excision repair_Homo sapiens_hsa034100.77106809
64Asthma_Homo sapiens_hsa053100.73638126
65HTLV-I infection_Homo sapiens_hsa051660.72273735
66Colorectal cancer_Homo sapiens_hsa052100.70356747
67Acute myeloid leukemia_Homo sapiens_hsa052210.68812806
68FoxO signaling pathway_Homo sapiens_hsa040680.67471188
69Fatty acid elongation_Homo sapiens_hsa000620.65029576
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63612537
71Pyrimidine metabolism_Homo sapiens_hsa002400.63385045
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62419909
73Purine metabolism_Homo sapiens_hsa002300.62059537
74Viral myocarditis_Homo sapiens_hsa054160.60918768
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60148777
76Tuberculosis_Homo sapiens_hsa051520.58182919
77Chemokine signaling pathway_Homo sapiens_hsa040620.54464524
78Non-small cell lung cancer_Homo sapiens_hsa052230.52412865
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51822167
80African trypanosomiasis_Homo sapiens_hsa051430.50365705
81Circadian rhythm_Homo sapiens_hsa047100.49358117
82N-Glycan biosynthesis_Homo sapiens_hsa005100.48126368
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45905098
84Toxoplasmosis_Homo sapiens_hsa051450.45453986
85Rheumatoid arthritis_Homo sapiens_hsa053230.43540222
86Hepatitis C_Homo sapiens_hsa051600.41817141
87Phototransduction_Homo sapiens_hsa047440.40882272
88Prolactin signaling pathway_Homo sapiens_hsa049170.39438110
89TGF-beta signaling pathway_Homo sapiens_hsa043500.39069196
90Apoptosis_Homo sapiens_hsa042100.38180725
91Pancreatic cancer_Homo sapiens_hsa052120.37951834
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37643934
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36154165
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33291465
95TNF signaling pathway_Homo sapiens_hsa046680.32376970
96Malaria_Homo sapiens_hsa051440.32194659
97Caffeine metabolism_Homo sapiens_hsa002320.32116032
98One carbon pool by folate_Homo sapiens_hsa006700.31305303
99Systemic lupus erythematosus_Homo sapiens_hsa053220.30396719
100Wnt signaling pathway_Homo sapiens_hsa043100.30280611

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